CN108220161B - Laboratory layout scheme for multi-cell preparation - Google Patents
Laboratory layout scheme for multi-cell preparation Download PDFInfo
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- CN108220161B CN108220161B CN201810065997.7A CN201810065997A CN108220161B CN 108220161 B CN108220161 B CN 108220161B CN 201810065997 A CN201810065997 A CN 201810065997A CN 108220161 B CN108220161 B CN 108220161B
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Abstract
The invention discloses a layout scheme of a multicellular preparation laboratory, which comprises a core preparation area, wherein a quality control area, a special sample preparation area, a third visiting corridor and a cargo area are respectively arranged on the periphery of the core preparation area; a first visiting corridor is arranged between the core preparation area and the quality control area, and a second visiting corridor is arranged between the core preparation area and the special sample preparation area; the third visiting corridor is communicated with the first visiting corridor and the second visiting corridor respectively; the cargo area is located between the first and second viewing corridors; a multifunctional display hall is arranged on one side of the cargo area opposite to the core preparation area; the multifunctional exhibition hall is adjacent to the special sample preparation area, the second visit corridor, the first visit corridor and the quality control area; the relative both sides in multi-functional show room are equipped with the stair.
Description
Technical Field
The invention belongs to the field of building design; in particular to a layout scheme of a multicellular preparation laboratory.
Background
With the improvement of science and technology in China, the cell preparation technology is also improved, and the cell preparation is applied to a wide range of fields; such as drug research and development, such as new drug screening, vaccine, gene engineering drug, cell engineering drug research and development, monoclonal antibody preparation, and the like; basic research, such as research on drug action mechanism, gene function, disease occurrence mechanism and the like; biopharmaceuticals, such as vaccine production: such as viral vaccines (hepatitis virus vaccine, AIDS vaccine, etc.), polypeptide vaccine, tumor vaccine, etc.; production of genetically engineered drugs: such as EPO, etc.; antibody medicine and gene therapy medicine production; production of cell engineering drugs: some bioactive polypeptides, bioactive substances, etc. within biological cells; measuring the activity of the bioactive substance in vitro by using a cell method; predicting the drug effect in vivo and detecting the biological activity of the finished product by an alternative in vivo method; however, the cell preparation laboratory needs high requirements, and consists of a main laboratory, an auxiliary room and an isolation device, wherein the main laboratory is also called as the environment requirement of the core area: the air purifier has the advantages that the air purifier has clear standard requirements on the cleaning level, the ventilation frequency, the minimum pressure difference relative to the atmosphere, the minimum pressure difference Pa between the room and the room which is adjacent and communicated in the outdoor direction, the temperature and humidity, the noise, the average illumination and the tightness of an enclosure structure, and the national standards (GB50346-2011) are clear standard requirements; these rooms and isolation devices need to be reasonably arranged to improve the working efficiency; the layout in the prior art is disordered, the relative positions of all functional rooms and the isolation devices are randomly arranged, and the requirements of the working process and the environment of the minicell experiment cannot be met.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides a layout scheme of a multi-cell preparation laboratory.
The specific technical scheme of the invention is as follows:
a layout scheme of a multi-cell preparation laboratory comprises a core preparation area, wherein a quality control area, a special sample preparation area, a third visiting corridor and a cargo area are respectively arranged on the periphery of the core preparation area; a first visiting corridor is arranged between the core preparation area and the quality control area, and a second visiting corridor is arranged between the core preparation area and the special sample preparation area; the third visiting corridor is communicated with the first visiting corridor and the second visiting corridor respectively; the cargo area is located between the first and second viewing corridors; a multifunctional display hall is arranged on one side of the cargo area opposite to the core preparation area; the multifunctional exhibition hall is adjacent to the special sample preparation area, the second visit corridor, the first visit corridor and the quality control area; the relative both sides in multi-functional show room are equipped with the stair.
Optimally, the core preparation area comprises a first preparation area, a second preparation area and a third preparation area which are adjacent to the third visit corridor on one side; a first clean corridor is arranged on the other side, opposite to the first preparation area; a second clean corridor is arranged on the other opposite side of the second preparation area and the third preparation area; a third clean corridor communicated with the first clean corridor is arranged between the first preparation area and the second preparation area, and a fourth clean corridor communicated with the second clean corridor is arranged between the second preparation area and the third preparation area; the first clean aisle is adjacent to the second clean aisle.
Preferably, a first immune cell culture chamber, a third immune cell preparation chamber, a second immune cell culture chamber, a fourth immune cell preparation chamber, a first dressing chamber, a second dressing chamber and an immune cell sample receiving chamber which are adjacent to the second observation corridor are sequentially arranged in the first preparation area from the third observation corridor to the first clean corridor; a first immune cell centrifugal chamber adjacent to the third immune cell preparation chamber is arranged on one side, away from the second observation corridor, of the first immune cell culture chamber; a second immune cell centrifugal chamber adjacent to the third immune cell preparation chamber and the fourth immune cell preparation chamber is arranged on one side, away from the second observation corridor, of the second immune cell preparation chamber; a first buffer area and a second buffer area are sequentially arranged on one side, away from the second visiting corridor, of the first changing room, the first buffer area is adjacent to the fourth immune cell preparation room, and the second buffer area is adjacent to the second changing room; and a first retreating and changing chamber adjacent to the second changing chamber and the first clean corridor is arranged on one side of the immune cell sample receiving chamber, which is far away from the second visiting corridor.
Preferably, a first waste outlet, a first gas cylinder room, a program-controlled cooling room, a stem cell culture and preparation issuing room, a stem cell culture room, an umbilical cord stem cell preparation room and an umbilical cord blood cell preparation room which are adjacent to the third clean corridor are sequentially arranged in the second preparation area from the third visit corridor to the second clean corridor; a second waste outlet is formed in one side, far away from the third clean corridor, of the first waste outlet; a second gas cylinder room is arranged on one side, far away from the third clean corridor, of the first gas cylinder room; two sides of the second gas cylinder are respectively adjacent to the second waste outlet and the program-controlled cooling chamber; a stem cell centrifugal chamber adjacent to the stem cell culture chamber is arranged on one side of the stem cell culture chamber, which is far away from the third clean corridor; the two sides of the stem cell centrifugal chamber are respectively adjacent to the stem cell culture and preparation distribution chamber and the umbilical cord stem cell preparation chamber; a short corridor is arranged between the first waste outlet and the first gas cylinder, and the other side of the short corridor is adjacent to the second waste outlet and the second gas cylinder.
Preferably, a placental blood cell preparation chamber, a centrifugal chamber, an adult adipose-derived stem cell preparation chamber, a culture chamber, a third buffer zone, a fourth buffer zone, a third dressing chamber and a second retreat chamber which are adjacent to the fourth clean corridor are sequentially arranged in the third preparation zone from the third visit corridor to the second clean corridor; a fourth changing room adjacent to the third buffer area and the fourth buffer area is arranged on one side, away from the fourth clean corridor, of the third buffer area, and two sides of the fourth changing room are adjacent to the culture room and the third changing room respectively; a stem cell sample receiving chamber adjacent to the second retreating chamber is arranged on one side, away from the fourth clean corridor, of the second retreating chamber; the stem cell sample receiving chamber is flanked by the third changing room and the second clean corridor, respectively.
Preferably, the special sample preparation area is sequentially provided with a working cell bank, a fifth changing room, a sixth changing room, a fifth clean corridor, a positive centrifugal chamber, a positive preparation culture chamber, a third waste outlet, a first transition chamber, a second transition chamber, a sample total receiving chamber and a sample collecting outer chamber which are adjacent to each other along the length direction of the second visit corridor; a third returning and replacing chamber adjacent to the fifth changing room is arranged on one side of the fifth changing room, which is far away from the second visiting corridor, and the third returning and replacing chamber is adjacent to the working cell bank; a fifth buffer chamber and a sixth buffer chamber which are adjacent to the sixth changing room are sequentially arranged on one side of the sixth changing room, which is far away from the second visiting corridor; a first clean material warehouse adjacent to both the first transition chamber and the second transition chamber is arranged on one side of the first transition chamber, which is far away from the second visit corridor; a waste temporary storage chamber adjacent to the sample collection outer chamber is sequentially arranged on one side of the sample collection outer chamber, which is far away from the second visit corridor; a fifth clean corridor is arranged between the third returning and replacing chamber and the first clean material warehouse, and the fifth clean corridor is adjacent to the fifth buffer chamber, the sixth buffer chamber, the positive centrifugal chamber and the positive preparation culture chamber; the fifth clean corridor is provided with two branch corridors, and one branch corridor is positioned between the sixth dressing room and the positive centrifugal chamber; another of the branched corridors is between the positive production culture chamber and the first clean material reservoir and is adjacent to the third waste outlet; and a double-door transfer window is arranged at the position of the third waste outlet and the positive preparation culture chamber.
Preferably, the quality control area is provided with a physicochemical chamber, a flow cell chamber, a microorganism culture chamber, a seventh buffer chamber, a sample receiving chamber, an eighth buffer chamber, a sample receiving chamber, a cleaning chamber and a decontamination chamber which are adjacent in sequence along the length direction of the first observation corridor; a freezing chamber adjacent to the sample receiving chamber is arranged on one side of the sample receiving chamber away from the first visiting corridor; said seventh buffer chamber being at a corner of said microbiological culture chamber and adjacent to both said first viewing corridor and said sample receiving chamber; the eighth buffer chamber is at a corner of the sample-receiving chamber and is adjacent to both the first viewing corridor and the sample-receiving chamber.
Preferably, a first material inlet, a second clean material warehouse, a third clean material warehouse and a second material inlet which are adjacent to the multifunctional exhibition hall are sequentially arranged in the cargo area from the first clean corridor to the second clean corridor; double-leaf transfer windows are arranged at the positions of the first material inlet, which are adjacent to the first clean corridor and the second clean material warehouse; and double-leaf transfer windows are arranged at the positions of the second material inlet, the second clean corridor and the third clean material warehouse, which are adjacent to each other.
Optimally, an emergency evacuation escape window is arranged at the position, adjacent to the second clean corridor, of the first clean corridor; an emergency evacuation escape window is arranged at the position, adjacent to the second visiting corridor, of the first clean corridor; an emergency evacuation escape window is arranged at the position, adjacent to the first visiting corridor, of the second clean corridor; the third clean corridor is adjacent to the third visiting corridor, and an emergency evacuation observation window is arranged at the adjacent position; and the fourth clean corridor and the third visit corridor are adjacent and are provided with emergency evacuation observation windows.
Preferably, the two ends of the multifunctional exhibition hall, which are far away from one side of the goods area, are provided with an access stair.
The invention has the following beneficial effects: the layout scheme of the multicellular preparation laboratory provided by the invention has the advantages of clear human flow, logistics and sewage flow, good safety performance, reasonable logistics, more convenient production operation, design meeting standards and specifications, safety, reliability, energy conservation and emission reduction, and certain guiding significance for engineering construction of biological laboratories, and can meet the requirements of clinical, diagnosis, observation teaching and research.
Drawings
FIG. 1 is a general diagram of a multi-cell preparation laboratory layout according to the present invention;
FIG. 2 is a schematic diagram of the layout of the core preparation area of a laboratory layout scheme for multi-cell preparation according to the present invention;
FIG. 3 is a layout diagram of a first preparation area of a laboratory layout protocol for multi-cell preparation according to the present invention;
FIG. 4 is a schematic diagram of a second preparation area of a laboratory layout for multi-cell preparation according to the present invention;
FIG. 5 is a schematic diagram of a third preparation area of a laboratory layout for multi-cell preparation according to the present invention;
FIG. 6 is a layout diagram of a special sample preparation area of a multi-cell preparation laboratory layout protocol according to the present invention;
FIG. 7 is a diagram of a quality control zone layout for a multi-cell preparation laboratory layout protocol according to the present invention;
FIG. 8 is a cargo area layout of a multi-cell preparation laboratory layout scheme according to the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
Referring to fig. 1, the present invention provides a layout scheme for a multi-cell preparation laboratory, which includes a core preparation area 7, wherein a quality control area 5, a special sample preparation area 8, a third visiting corridor 6 and a cargo area 3 are respectively disposed around the core preparation area 7; a first visiting corridor 4 is arranged between the core preparation area 7 and the quality control area 5, and a second visiting corridor 2 is arranged between the core preparation area 7 and the special sample preparation area 8; the third corridor of observation 6 is in communication with the first corridor of observation 4 and the second corridor of observation 2, respectively; the cargo area 3 is located between the first and second visiting corridors 4, 2; a multifunctional exhibition hall 1 is arranged on one side of the cargo area 3 opposite to the core preparation area 7; the multifunctional exhibition hall 1 is adjacent to the special sample preparation area 8, the second visiting corridor 2, the first visiting corridor 4 and the quality control area 5; the relative both sides of multi-functional show room 1 are equipped with the stair.
It is to be noted that each chamber is provided with an access door, and the adjacent positions of a plurality of adjacent laboratories are provided with a transfer window; when the intelligent stair-climbing robot is used, which laboratory is selected to enter according to the self condition, if the intelligent stair-climbing robot enters the quality control area, stairs close to the quality control area can be selected to enter, and the first visiting corridor, the second visiting corridor and the third visiting corridor are used for visiting and learning; the multiple channels are arranged, so that the effect of rapidly entering a target working area is achieved.
Example 2
Further, referring to fig. 2, the core preparation area 7 includes a first preparation area 71, a second preparation area 72 and a third preparation area 73 adjacent to the third corridor for visiting 6 on one side; a first clean corridor 74 is arranged on the opposite side of the first preparation area 71; a second clean corridor 76 is arranged on the opposite side of the second preparation area 72 and the third preparation area 73; a third clean corridor 75 communicating with the first clean corridor 74 is provided between the first preparation area 71 and the second preparation area 72, and a fourth clean corridor 77 communicating with the second clean corridor 76 is provided between the second preparation area 72 and the third preparation area 73; the first clean corridor 74 is adjacent to the second clean corridor 76.
Can select which laboratory of entering during the use according to self condition, if select the first preparation district in core preparation district, the stair that can select to be close to first preparation district enters into multi-functional show room, gets into the second after through multi-functional show room and visits the corridor, and the accessible second visits the corridor and gets into inside first preparation district.
Example 3
Further, as shown in fig. 3, a first immune cell culture chamber 711, a third immune cell preparation chamber 712, a second immune cell culture chamber 713, a fourth immune cell preparation chamber 714, a first dressing chamber 715, a second dressing chamber 718 and an immune cell sample receiving chamber 716 which are adjacent to the second observation corridor 2 are sequentially arranged in the first preparation area 71 from the third observation corridor 6 to the first clean corridor 74; a first immune cell centrifugal chamber 7112 adjacent to the third immune cell preparation chamber 712 is arranged on one side of the first immune cell culture chamber 711 away from the second observation corridor 2; a second immune cell centrifugal chamber 7111 adjacent to both the third immune cell preparation chamber 712 and the fourth immune cell preparation chamber 714 is arranged at one side of the second immune cell preparation chamber 713 away from the second observation corridor 2; a first buffer area 7110 and a second buffer area 719 are sequentially arranged on one side of the first changing room 715 away from the second observation corridor 2, the first buffer area 7110 is adjacent to the fourth immune cell preparation room 714, and the second buffer area 719 is adjacent to the second changing room 718; the side of the immune cell sample receiving chamber 716 away from the second observation corridor 2 is provided with a first retreat chamber 717 adjacent to both the second dressing chamber 718 and the first clean corridor 74.
When the clothes changing cabinet is used, the clothes, shoes and the like are firstly changed in the second changing room, enter the second buffer area after passing through the second changing room, enter the first changing room through the second buffer area, enter the first changing room, change clean clothes, disinfect hands and the like, enter the first buffer area through the first changing room, enter the third clean corridor through the first buffer area, and enter each laboratory in the first preparation area through the third clean corridor for working; and after the experiment is finished, the sample enters a first retreating and replacing room through a third clean corridor, enters the retreating and replacing room to take off the laboratory clothes, and exits from the first preparation area from a second dressing room after exiting and replacing the room.
Example 4
Further, as shown in fig. 4, a first waste outlet 726, a first gas cylinder room 725, a program-controlled cooling room 724, a stem cell culture and preparation dispensing room 728, a stem cell culture room 723, an umbilical cord stem cell preparation room 722 and an umbilical cord blood cell preparation room 721 adjacent to the third clean corridor 75 are sequentially arranged in the second preparation area 72 from the third visit corridor 6 to the second clean corridor 76; a second waste outlet 7210 is arranged on the side of the first waste outlet 726 away from the third clean corridor 75; a second gas cylinder room 729 is arranged on one side of the first gas cylinder room 725 away from the third clean corridor 75; two sides of the second gas cylinder chamber 729 are respectively adjacent to the second waste outlet 7210 and the program-controlled cooling chamber 724; a stem cell centrifugal chamber 727 adjacent to the stem cell culture chamber 723 is arranged on the side, away from the third clean corridor 75, of the stem cell culture chamber 727; the stem cell centrifugal chamber 727 is respectively adjacent to the stem cell culture and preparation delivering chamber 728 and the umbilical cord stem cell preparation chamber 722 on two sides; a short corridor is provided between the first waste outlet 726 and the first gas cylinder bay 725, the other side of the short corridor being adjacent to the second waste outlet 726 and the second gas cylinder bay 729.
When in use, the laboratory can be selected according to the self condition, such as selecting the second preparation area of the core preparation area; selecting a proper stair to enter a multifunctional exhibition hall, entering a first visit corridor after passing through the multifunctional exhibition hall, entering a third preparation area through the first visit corridor, entering a fourth clean corridor through the third preparation area, and respectively entering each laboratory of a second preparation area through the fourth clean corridor for working; waste produced in the second preparation area may be transported through the fourth clean corridor to the second waste outlet for treatment; after the experiment is finished, the test sample enters a second clean corridor through a fourth clean corridor, enters a third preparation area through the second clean corridor, and exits the core preparation area through the third preparation area; waste generated in the first preparation area can be transported to the first waste outlet for disposal through the third clean corridor.
Example 5
Further, as shown in fig. 5, a placental blood cell preparation chamber 731, a centrifugal chamber 732, an adult adipose-derived stem cell preparation chamber 733, a culture chamber 734, a third buffer region 7310, a fourth buffer region 739, a third dressing chamber 737, and a second retreat chamber 738 are sequentially disposed in the third preparation region 73 from the third observation corridor 6 to the second clean corridor 76, adjacent to the fourth clean corridor 77; a fourth changing room 735 adjacent to the third buffer 7310 and the fourth buffer 739 is disposed on a side of the third buffer 7310 away from the fourth clean corridor 77, and both sides of the fourth changing room 735 are adjacent to the cultivation room 734 and the third changing room 737, respectively; a stem cell sample receiving chamber 736 adjacent to the second retreating chamber 738 is arranged on one side far away from the fourth clean corridor 77; the stem cell sample receiving chamber 736 is flanked by the third dressing chamber 737 and the second clean corridor 76, respectively.
When the multifunctional display hall is used, the multifunctional display hall is entered from the stairs, the first visit corridor is entered after passing through the multifunctional display hall, the third dressing room, the fourth buffer zone, the fourth dressing room and the third buffer zone are sequentially entered through the first visit corridor, and then the target laboratory needing to be tested is entered through the fourth clean corridor; after the experiment is completed, the second clean corridor is entered through the fourth clean corridor, the second clean corridor is entered into the second room to remove the lab coat, the third room is entered into the third room, and the first visit corridor is entered into the third room.
Example 6
Further, referring to fig. 6, the special sample preparation area 8 is sequentially provided with a working cell bank 81, a fifth dressing room 88, a sixth dressing room 811, a fifth clean corridor 83, a positive centrifugal room 812, a positive preparation culture room 813, a third waste outlet 817, a first transition room 816, a second transition room 815, a total sample receiving room 85 and a sample collecting outer room 814 along the length direction of the second visiting corridor 2; a third retreating and changing chamber 82 adjacent to the fifth changing room 88 is arranged on the side, away from the second visiting corridor 2, of the fifth changing room 82, and the third retreating and changing chamber 82 is adjacent to the working cell bank 81; a fifth buffer chamber 89 and a sixth buffer chamber 810 which are adjacent to the sixth changing room 811 are sequentially arranged on one side of the sixth changing room 811 away from the second visiting corridor 2; a first clean material storage 84 adjacent to the first transition chamber 816 and the second transition chamber 815 is arranged on one side of the first transition chamber 816, which is far away from the second observation corridor 2; the sample collection outer chamber 814 is provided with a temporary waste storage chamber 86 adjacent to the sample collection outer chamber in sequence at one side far away from the second visit corridor 2; a fifth clean corridor 83 is arranged between the third refuge chamber 82 and the first clean material storage 84, and the fifth clean corridor 83 is adjacent to the fifth buffer chamber 89, the sixth buffer chamber 810, the positive centrifugal chamber 812 and the positive preparation culture chamber 813; the fifth clean corridor 83 is provided with two branched corridors, one of which is located between the sixth dressing room 811 and the positive centrifugal chamber 812; another of the branched corridors is between the positive preparation growth chamber 813 and the first clean material reservoir 84 and is adjacent to the third waste outlet 817; a double-door transmission window is arranged at the position where the third waste outlet 817 is adjacent to the positive preparation culture chamber 813.
It should be noted that each room is provided with an access door, when in use, the room can be selected to enter according to the self condition, if necessary, the positive cells can be prepared and cultured, the positive cells can enter the multifunctional exhibition hall from the stair opening of the multifunctional exhibition hall close to the special sample preparation area, enter the second visit corridor after passing through the multifunctional exhibition hall, enter the fifth changing room from the second visit corridor, enter the fifth buffer room after passing through the fifth changing room, enter the sixth changing room after passing through the fifth buffer room, enter the sixth buffer room after passing through the sixth changing room, enter the fifth clean corridor after passing through the sixth buffer room, and respectively enter the positive centrifugal room, the positive preparation culture room and the clean material warehouse from the fifth clean corridor; waste generated during working in the positive preparation culture chamber can be conveyed into a third waste outlet from a double-door transfer window arranged between the adjacent two, then a worker conveys the first waste outlet and the second waste outlet from a second visit corridor to a third visit corridor, and the waste at the third waste outlet is conveyed to a temporary waste storage place through a multifunctional display hall; when taking materials, the worker can enter the first clean material storage from the fifth clean corridor for direct extraction, and the materials are conveyed through the double-leaf delivery window at the adjacent part of the first transition room and the branch corridor; the sample received by the sample receiving outer chamber can be conveyed through a sliding window arranged between the sample total receiving chamber and the sample receiving outer chamber.
Example 7
Further, as shown in fig. 7, the quality control area 5 is provided with a physicochemical chamber 51, a flow cell chamber 52, a microorganism culture chamber 53, a seventh buffer chamber 54, a sample receiving chamber 510, an eighth buffer chamber 59, a sample receiving chamber 58, a cleaning chamber 56 and a decontamination chamber 55 which are adjacent to each other along the length direction of the first observation corridor 4; the sample receiving chamber 58 is provided with a freezing chamber 57 adjacent to the side thereof remote from the first corridor of observation 4; said seventh buffer chamber 54 is at a corner of said microbiological culture chamber 53 and is adjacent to both said first observation corridor 4 and said sample receiving chamber 510; the eighth buffer chamber 59 is at a corner of the sample-receiving chamber 510 and is adjacent to both the first viewing corridor 4 and the sample-receiving chamber 58.
During the use, enter into multi-functional show room from stair, get into first corridor of visiting behind multi-functional show room, get into each laboratory in the quality control district through first corridor of visiting in proper order.
Example 8
Further, as shown in fig. 8, a first material inlet 31, a second clean material storage 32, a third clean material storage 33 and a second material inlet 34 adjacent to the multi-functional exhibition hall 1 are sequentially arranged in the cargo area 3 from the first clean corridor 74 to the second clean corridor 76; double-leaf delivery windows are arranged at the positions of the first material inlet 31, which are adjacent to the first clean corridor 74 and the second clean material warehouse 32; the second material inlet 32 is provided with double leaf transfer windows adjacent to the second clean corridor 76 and the third clean material storage 33.
The double-door transfer window is used for transferring goods.
Example 9
Further, the first clean corridor 74 is provided with an emergency evacuation escape window adjacent to the second clean corridor 76; an emergency evacuation escape window is arranged at the position, adjacent to the second visit corridor 2, of the first clean corridor 74; an emergency evacuation escape window is arranged in the second clean corridor 74 adjacent to the first visiting corridor 4; the third clean corridor 75 is adjacent to the third visiting corridor 6, and an emergency evacuation observation window is arranged at the adjacent position; the fourth clean corridor 77 is adjacent to the third visiting corridor 6 and is provided with an emergency evacuation observation window.
The emergency evacuation escape window is used for avoiding danger and escaping in time when an emergency occurs.
Furthermore, the two ends of the multifunctional exhibition hall 1, which are far away from one side of the goods area 3, are provided with an access stair.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and it will be apparent to those skilled in the art that various modifications and variations can be made in the present invention; any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (8)
1. A multi-cell preparation laboratory comprising a core preparation area (7), characterized in that: a quality control area (5), a special sample preparation area (8), a third visiting corridor (6) and a goods area (3) are respectively arranged on the periphery of the core preparation area (7); a first visiting corridor (4) is arranged between the core preparation area (7) and the quality control area (5), and a second visiting corridor (2) is arranged between the core preparation area (7) and the special sample preparation area (8); the third visit corridor (6) is respectively communicated with the first visit corridor (4) and the second visit corridor (2); -the cargo area (3) is located between the first and second corridor of visits (4, 2); a multifunctional exhibition hall (1) is arranged on one side of the cargo area (3) opposite to the core preparation area (7); the multifunctional exhibition hall (1) is adjacent to the special sample preparation area (8), the second visit corridor (2), the first visit corridor (4) and the quality control area (5); stairs are arranged on two opposite sides of the multifunctional display hall (1);
the core preparation area (7) comprises a first preparation area (71), a second preparation area (72) and a third preparation area (73) adjacent to the third corridor of observation (6) on one side; a first clean corridor (74) is arranged on the other side, opposite to the first preparation area (71); the opposite sides of the second preparation area (72) and the third preparation area (73) are provided with a second clean corridor (76); a third clean corridor (75) communicated with the first clean corridor (74) is arranged between the first preparation area (71) and the second preparation area (72), and a fourth clean corridor (77) communicated with the second clean corridor (76) is arranged between the second preparation area (72) and the third preparation area (73); the first clean corridor (74) is adjacent to the second clean corridor (76);
a first waste outlet (726), a first gas cylinder room (725), a program-controlled cooling room (724), a stem cell culture and preparation issuing room (728), a stem cell culture room (723), an umbilical cord stem cell preparation room (722) and an umbilical cord blood cell preparation room (721) which are adjacent to the third clean corridor (75) are sequentially arranged in the second preparation area (72) from the third visit corridor (6) to the second clean corridor (76); a second waste outlet (7210) is arranged on the side, away from the third clean corridor (75), of the first waste outlet (726); a second gas cylinder room (729) is arranged on one side, away from the third clean corridor (75), of the first gas cylinder room (725); two sides of the second gas cylinder chamber (729) are respectively adjacent to the second waste outlet (7210) and the program-controlled cooling chamber (724); a stem cell centrifugal chamber (727) adjacent to the stem cell culture chamber (723) is arranged on one side, away from the third clean corridor (75); the two sides of the stem cell centrifugal chamber (727) are respectively adjacent to the stem cell culture and preparation dispensing chamber (728) and the umbilical cord stem cell preparation chamber (722); a short corridor is provided between the first waste outlet (726) and the first cylinder room (725), the other side of the short corridor being adjacent to the second waste outlet (7210) and the second cylinder room (729).
2. The multi-cell preparation laboratory according to claim 1, wherein a first immune cell culture chamber (711), a third immune cell preparation chamber (712), a second immune cell culture chamber (713), a fourth immune cell preparation chamber (714), a first dressing chamber (715), a second dressing chamber (718) and an immune cell sample receiving chamber (716) are sequentially disposed inside the first preparation area (71) from the third corridor (6) to the first clean corridor (74) adjacent to the second corridor (2); a first immune cell centrifugal chamber (7112) adjacent to the third immune cell preparation chamber (712) is arranged on one side of the first immune cell culture chamber (711) far away from the second observation corridor (2); a second immune cell centrifugal chamber (7111) which is adjacent to the third immune cell preparation chamber (712) and the fourth immune cell preparation chamber (714) is arranged on one side, away from the second observation corridor (2), of the second immune cell culture chamber (713); a first buffer area (7110) and a second buffer area (719) are sequentially arranged on one side, away from the second visiting corridor (2), of the first dressing room (715), the first buffer area (7110) is adjacent to the fourth immune cell preparation room (714), and the second buffer area (719) is adjacent to the second dressing room (718); the side of the immune cell sample receiving chamber (716) far away from the second visit corridor (2) is provided with a first retreat chamber (717) adjacent to the second dressing chamber (718) and the first clean corridor (74).
3. The multi-cell preparation laboratory according to claim 1, wherein a placental blood cell preparation chamber (731), a centrifugal chamber (732), an adult adipose stem cell preparation chamber (733), a culture chamber (734), a third buffer region (7310), a fourth buffer region (739), a third dressing chamber (737), a second retreat chamber (738) are sequentially disposed inside the third preparation region (73) from the third observation corridor (6) to the second clean corridor (76) adjacent to the fourth clean corridor (77); a fourth dressing room (735) adjacent to the third buffer area (7310) and the fourth buffer area (739) is arranged on one side of the third buffer area (7310) far away from the fourth clean corridor (77), and two sides of the fourth dressing room (735) are respectively adjacent to the culture room (734) and the third dressing room (737); a stem cell sample receiving chamber (736) adjacent to the second retreating chamber (738) is arranged on one side of the second retreating chamber (738) far away from the fourth clean corridor (77); the stem cell sample receiving chamber (736) is flanked by the third dressing chamber (737) and a second clean corridor (76), respectively.
4. The multi-cell preparation laboratory according to claim 1, wherein said special sample preparation area (8) is provided with a working cell bank (81), a fifth dressing room (88), a sixth dressing room (811), a fifth clean corridor (83), a positive centrifugal room (812), a positive preparation culture room (813), a third waste outlet (817), a first transition room (816), a second transition room (815), a total sample receiving room (85) and an outer sample collecting room (814) which are adjacent to each other along the length direction of said second observation corridor (2); a third retreating and changing chamber (82) adjacent to the fifth changing room (88) is arranged on one side of the fifth changing room (88) far away from the second visiting corridor (2), and the third retreating and changing chamber (82) is adjacent to the working cell bank (81); a fifth buffer chamber (89) and a sixth buffer chamber (810) which are adjacent to the sixth dressing chamber (811) are sequentially arranged on one side, away from the second visiting corridor (2), of the sixth dressing chamber; a first clean material storage (84) adjacent to both the first transition chamber (816) and the second transition chamber (815) is arranged on one side of the first transition chamber (816) far away from the second observation corridor (2); a waste temporary storage chamber (86) adjacent to the sample collection outer chamber (814) is sequentially arranged on one side of the sample collection outer chamber, which is far away from the second visiting corridor (2); a fifth clean corridor (83) is arranged between the third returning and replacing chamber (82) and the first clean material storage (84), and the fifth clean corridor (83) is adjacent to the fifth buffer chamber (89), the sixth buffer chamber (810), the positive centrifugal chamber (812) and the positive preparation culture chamber (813); said fifth clean corridor (83) is provided with two branching corridors, one of which is located between said sixth changing room (811) and a positive centrifugal chamber (812); another said branched corridor being between said positive preparation culture chamber (813) and said first clean material store (84) and adjacent to said third waste outlet (817); a double-door transfer window is arranged at the position of the third waste outlet (817) adjacent to the positive preparation culture chamber (813).
5. A multi-cell preparation laboratory according to claim 1, wherein said quality control area (5) is provided with a physicochemical chamber (51), a flow cell chamber (52), a microorganism culture chamber (53), a seventh buffer chamber (54), a first sample receiving chamber, an eighth buffer chamber (59), a second sample receiving chamber, a clean chamber (56) and a wash and sterilize chamber (55) which are adjacent in sequence along the length of said first observation corridor (4); the second sample receiving chamber is provided with a freezing chamber (57) adjacent to the second sample receiving chamber on the side far away from the first access corridor (4); said seventh buffer chamber (54) being at a corner of said microbiological culture chamber (53) and adjacent to both said first observation corridor (4) and said first sample receiving chamber; the eighth buffer chamber (59) is at a corner of the first sample-receiving chamber and adjacent to both the first viewing corridor (4) and the second sample-receiving chamber.
6. A multi-cell preparation laboratory according to claim 1, characterized in that a first material inlet (31), a second clean material store (32), a third clean material store (33) and a second material inlet (34) are provided inside the cargo area (3) in sequence from the first clean corridor (74) to the second clean corridor (76) adjacent to the multi-functional showroom (1); double-leaf delivery windows are arranged at the positions of the first material inlet (31), which are adjacent to the first clean corridor (74) and the second clean material warehouse (32); and double-leaf transfer windows are arranged at the positions of the second material inlet (34), which are adjacent to the second clean corridor (76) and the third clean material storage (33).
7. A multi-cell preparation laboratory according to claim 1, wherein said first clean corridor (74) is provided with an emergency evacuation escape window adjacent to said second clean corridor (76); an emergency evacuation escape window is arranged at the position, adjacent to the second visit corridor (2), of the first clean corridor (74); an emergency evacuation escape window is arranged at the position, adjacent to the first visit corridor (4), of the second clean corridor (76); the third clean corridor (75) is adjacent to the third visiting corridor (6), and an emergency evacuation observation window is arranged at the adjacent position; and the fourth clean corridor (77) is adjacent to the third visiting corridor (6) and an emergency evacuation observation window is arranged at the adjacent position.
8. A multi-cell preparation laboratory according to claim 7, wherein said multifunctional showroom (1) is provided with access stairs at both ends of the side away from said cargo area (3).
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