CN212453801U - Integrated mobile pathogen nucleic acid detection laboratory system - Google Patents
Integrated mobile pathogen nucleic acid detection laboratory system Download PDFInfo
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- CN212453801U CN212453801U CN202021582829.4U CN202021582829U CN212453801U CN 212453801 U CN212453801 U CN 212453801U CN 202021582829 U CN202021582829 U CN 202021582829U CN 212453801 U CN212453801 U CN 212453801U
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Abstract
The utility model relates to an integrated mobile pathogen nucleic acid detection laboratory system, which is characterized in that the three main steps of reagent storage and preparation, sample preparation, amplification and product analysis related to the nucleic acid detection process are respectively integrated in a mobile structure in a mutually airtight isolation manner, and separate personnel access passages are provided for the three main steps in a partition manner, so that personnel crosstalk is not generated among the three main steps, and the isolation requirements among the three steps in the nucleic acid detection process are realized; meanwhile, the integrated movable structure can be quickly moved, deployed to any required position and unfolded to form a pathogen nucleic acid detection laboratory with complete functions, so that the detection is performed on the spot at the key prevention and control position, and the concentrated transfer of high risk groups is avoided.
Description
Technical Field
The utility model relates to a pathogen detection equipment technical field especially relates to a portable pathogen nucleic acid detection laboratory system of integrated form.
Background
The novel coronary pathogen is an airborne pathogen with the characteristics of strong infectivity and strong pathogenicity, often presents explosive diffusion infection in community people, and poses a very serious threat to the life health of people.
Because no specific medicine exists for pneumonia and other diseases caused by the novel coronary pathogens at present, the early discovery and isolation of infected people become the most effective means for preventing and treating the novel coronary pathogens. The most commonly used nucleic acid detection method at present is a screening means with high public accuracy and reliable result, but the nucleic acid detection generally needs to be operated in a detection laboratory meeting the requirements, so that the number of the detection laboratories is not enough to meet huge detection requirements, the nucleic acid detection efficiency is severely restricted, and the optimal treatment time is delayed in the process of waiting for the nucleic acid detection by a plurality of patients, so that the disease condition is aggravated. Therefore, there is an urgent need for a mobile nucleic acid detection laboratory system that meets biosafety laboratory standards.
SUMMERY OF THE UTILITY MODEL
For solving prior art's not enough, the utility model provides a portable pathogen nucleic acid detection laboratory system of integrated form, through the reagent preparation that involves with the nucleic acid testing process, sample treatment, the integration setting that the three main step of sample analysis is airtight isolation each other respectively is in a movable structure, and provide solitary personnel access passage for three main step subregion and make and do not produce personnel to cross talk each other, realize among the nucleic acid testing process to the isolation requirement between the three step, integrated form movable structure can quick travel arrange to arbitrary demand position and expand and form a pathogen nucleic acid detection laboratory that has complete function simultaneously, realize that key prevention and control position carries out the detection on the spot, avoid high risk group to concentrate the transfer.
In order to achieve the above object, the utility model discloses the technical scheme who adopts includes:
an integrated mobile laboratory system for pathogen nucleic acid detection comprising reagent storage and preparation stand-alone structures, specimen preparation stand-alone structures and amplification and product analysis stand-alone structures hermetically isolated from each other integrated within a mobile structure;
the reagent storage and preparation independent structure comprises a first inlet buffer room and a reagent preparation room which are connected in turn in an airtight way, and the side walls of the reagent preparation room are respectively provided with at least one airtight transmission window which is connected with the external environment and the sample preparation independent structure;
the sample preparation independent structure comprises a second inlet buffer room, a sample preparation room maintaining a negative pressure environment, a second outlet buffer room and a decontamination room which are connected in an airtight mode in sequence to form a one-way airtight personnel channel relative to the external environment, and the side wall of the sample preparation room is at least provided with an airtight transfer window connected with the external environment;
the independent amplification and product analysis structure comprises a third inlet buffer room and an amplification and analysis room maintaining a negative pressure environment which are connected in an airtight mode in sequence, and the side wall of the amplification and analysis room is provided with at least one airtight transfer window connected with the independent specimen preparation structure; the decontamination room is also provided with an airtight transfer window connected with the amplification analysis room;
and the negative pressure environmental pressure value of the sample preparation room is always lower than the environmental pressure values of other positions in the system.
Further, the system also comprises a central control room and an electric equipment room which are integrated in the same movable structure and are separately and hermetically isolated.
Furthermore, a negative pressure environment is maintained between the second inlet buffer room and the second outlet buffer room, and the negative pressure environment pressure value of the second outlet buffer room is higher than the environmental pressure value of the decontamination room; the negative pressure environmental pressure value of the amplification analysis room is higher than the environmental pressure value of the decontamination room, and a pressure difference exists between the amplification analysis room and the third inlet buffer room; a pressure differential exists between the reagent preparation compartment and the first inlet buffer compartment.
Furthermore, an external power interface, a generator, a power distribution cabinet electrically connected with the reagent storage and preparation independent structure, the specimen preparation independent structure, the amplification and product analysis independent structure and the control room are arranged in the power equipment room, and an independent air conditioner external unit is also arranged in the power equipment room; and a pressure monitoring device for collecting environmental pressure value data of the reagent storage and preparation independent structure, the sample preparation independent structure, the amplification and product analysis independent structure is arranged in the middle control room.
Furthermore, a reagent storage device and an ultra-clean workbench for placing a reagent preparation instrument are arranged in the reagent preparation room; an inactivation constant temperature box, a refrigeration refrigerator, a biological safety cabinet and a nucleic acid extractor are arranged in the sample preparation room; at least one PCR analyzer is arranged in the amplification analysis room; the decontamination room is provided with an autoclave and a waste garbage can.
Furthermore, wardrobes are respectively arranged in the first inlet buffer room, the second inlet buffer room and the third inlet buffer room.
Further, the movable structure is a 45HQ container.
Further, the bottom of the container is provided with mounting feet or independent skids.
The utility model has the advantages that:
adopt portable pathogen nucleic acid detection laboratory system of integrated form bears respectively the different steps of carrying out among the nucleic acid testing process between the function of mutual isolation on a movable structure through the integration, can the different operational environment of adjustment of pertinence: for the sample processing step involving pathogen contact, a negative pressure environment is adopted to prevent the pathogen from accidentally leaking, ensure safety and prevent secondary transmission. On this basis, three mutual airtight isolated's independent structure can satisfy personnel and do not cross talk, the one-way moving wire design of article, forms complete airtight isolation protection, avoids the pollutant diffusion, accords with the national mandatory standard requirement completely. By applying the integrated mobile pathogen nucleic acid detection laboratory system, the nucleic acid detection capability can be rapidly mobilized to a hotspot demand area, the detection capability is rapidly formed, time-consuming laboratory construction is not needed, and the sudden detection capability shortage of a specific area is compensated by the function of rapid trans-regional allocation of the existing nucleic acid detection capability; meanwhile, the mobile detection capability can effectively avoid concentrated transportation and aggregation of a large number of high risk groups, and is beneficial to the orderly development of large-scale nucleic acid detection matters.
Drawings
FIG. 1 is a schematic diagram of an embodiment of an integrated mobile pathogen nucleic acid detection laboratory system according to the present invention.
Description of the figure numbering: 1-reagent storage and preparation independent structure, 11-reagent preparation room, 111-reagent storage equipment, 112-clean bench, 12-first inlet buffer room, 2-specimen preparation independent structure, 21-sample preparation room, 211-inactivation constant temperature box, 212-refrigerator, 213-biological safety cabinet, 214-nucleic acid extractor, 22-second inlet buffer room, 23-decontamination room, 231-autoclave, 232-waste garbage can, 24-second outlet buffer room, 3-amplification and product analysis independent structure, 31-amplification analysis room, 311-PCR analyzer, 32-third inlet buffer room, 4-airtight transfer window, 5-central control room, 51-pressure monitoring device, 6-electric equipment room, 61-generator, 62-power distribution cabinet, 63-air conditioner external unit and 7-wardrobe.
Detailed Description
For a clearer understanding of the present invention, reference will be made to the following detailed description of the embodiments with reference to the accompanying drawings.
At present, pathogen nucleic acid detection laboratories are generally arranged in fixed facilities such as hospitals or related research institutes, and detection samples need to be collected and then are intensively sent to the detection laboratories for detection. Such a laboratory setting mode is inconvenient for short-term expansion of detection capability and reasonable configuration of detection capability, and often results in the situation that detection capability of key areas is seriously insufficient, and simultaneously detection capability of non-hotspot areas is greatly idle and wasted, which does not meet practical requirements of epidemic situation resistance. Through using the portable pathogen nucleic acid detection laboratory system of integrated form can form pathogen nucleic acid detection ability fast, can deal with the detection of any kind of pathogen, and is particularly useful for the airborne pathogen of strong infectivity, strong pathogenicity characteristics such as novel coronary pathogen.
Referring to FIG. 1, a schematic diagram of a preferred embodiment of the integrated mobile pathogen nucleic acid detection laboratory system of the present invention is shown, which is preferably composed of a reagent storage and preparation independent structure 1, a specimen preparation independent structure 2 and an amplification and product analysis independent structure 3 hermetically isolated from each other, integrated in a mobile structure; the movable structure is particularly preferably a 45HQ size container with the addition of mounting feet or skids to assist in system deployment. The reagent storage and preparation independent structure 1 corresponds to a reagent storage and preparation area in a nucleic acid detection laboratory and is responsible for preparing a stored reagent, subpackaging the reagent and preparing an amplification reaction mixed solution and storing and preparing consumables such as a centrifuge tube, a suction head and the like; the specimen preparation independent structure 2 corresponds to a specimen preparation area in a nucleic acid detection laboratory and is responsible for extracting, storing and adding nucleic acid (RNA and DNA) into an amplification reaction tube, particularly, the specimen preparation independent structure 2 can relate to the operation of clinical samples and can meet the requirements of biological safety secondary laboratory protection equipment, personal protection and operation specifications; the independent amplification and product analysis structure 3 corresponds to an amplification area and an amplification product analysis area in a nucleic acid detection laboratory and is responsible for cDNA synthesis, DNA amplification and detection, and further analysis and determination of amplified fragments, such as hybridization, enzyme digestion electrophoresis, denaturing high performance liquid analysis, sequencing and the like. The reagent storage and preparation independent structure 1 comprises a first inlet buffer room 12 and a reagent preparation room 11 with adjustable ambient pressure value which are connected in turn in an airtight way, and the side walls of the reagent preparation room 11 are respectively provided with at least one airtight transmission window 4 which is connected with the external environment and the sample preparation room 21 in the specimen preparation independent structure 2. As required, functional components such as a nucleic acid detection reagent preparing unit, a nucleic acid detection reagent dispensing unit, and a nucleic acid detection reagent storing unit may be provided in the reagent preparing chamber 11, and particularly, the reagent preparing chamber may include a reagent storage device 111 and a clean bench 112 on which a reagent preparing apparatus is placed. The specimen preparation independent structure 2 comprises a second inlet buffer room 22, a sample preparation room 21 maintaining a negative pressure environment, a second outlet buffer room 24 and a decontamination room 23 which are connected in sequence in an airtight manner, a one-way airtight personnel channel relative to an external environment is formed, and at least one airtight transfer window 4 connected with the external environment is arranged on the side wall of the sample preparation room 21. According to the requirement, the sample preparation room 21 may be provided with functional components such as a sample inactivation component, a sample nucleic acid extraction component, a nucleic acid sample adding component, a to-be-detected reagent sealing component, and the like, and particularly may include necessary devices such as an inactivation thermostat 211, a refrigerator 212, a biological safety cabinet 213, a nucleic acid extractor 214, and the like. The independent amplification and product analysis structure 3 comprises a third inlet buffer room 32 and an amplification and analysis room 31 maintaining a negative pressure environment, which are hermetically connected in sequence, at least one airtight transmission window 4 connected with the sample preparation room 21 in the independent specimen preparation structure 2 is arranged on the side wall of the amplification and analysis room 31, and preferably, the airtight transmission window 4 connected with the amplification and analysis room 31 is also arranged on the decontamination room 23. An autoclave 231 and a waste bin 232 for disposing waste are preferably provided in the decontamination chamber 23. By providing a plurality of airtight transfer windows 4 between the three separate structures, a contactless secure transfer path of the article can be provided. The first entrance buffer room 12, the second entrance buffer room 22 and the third entrance buffer room 32 are preferably provided with wardrobes 7 respectively for storing the replacement clothes and protective clothing for workers.
Preferably, the movable structure is further provided with a central control room 5 and an electric equipment room 6 for assisting the above independent structure to work, and particularly, the central control room 5 and the electric equipment room 6 can be selectively arranged at two ends of the movable structure respectively. The power equipment room 6 is provided with an external power supply interface, a generator 61 and a power distribution cabinet 62 which is electrically connected with the reagent storage and preparation independent structure, the specimen preparation independent structure, the amplification and product analysis independent structure and the control room, can ensure stable power consumption for nucleic acid detection through various composite power sources, especially ensure long-time stable operation of equipment such as reagent storage equipment, a refrigerator and the like, and is also provided with an independent air conditioner external unit for adjusting the temperature in each independent structure. The central control room 5 is provided with a pressure monitoring device 51 for collecting the environmental pressure value data of the reagent storage and preparation independent structure, the sample preparation independent structure, the amplification and product analysis independent structure, and is used for monitoring the environmental pressure value of each independent structure, and when an abnormal pressure condition occurs, a warning prompt can be timely sent out and/or necessary emergency measures can be automatically taken; the central control room 5 can also be preferably provided with a fresh air conditioning box and an air conditioning control device.
Airtight pass-through box 4 can guarantee the structure gas tightness in the article transmission process through opening first airtight door and second airtight door in proper order including the first airtight door and the second airtight door that open simultaneously. Of course other airtight pass-through box designs can also be used in the present invention to achieve the same technical effect.
In order to further satisfy laboratory safety needs, especially will stop the possibility that airborne virus pollutes external environment, but movable structure in different positions adopted different ambient pressure value, form the pressure gradient design, guarantee that the contaminated area air can not leak to external environment. Preferably, the negative pressure environmental pressure value of the sample preparation room 21 is the lowest in the whole system, so as to ensure that the air flow in the sample preparation room 21 does not leak; the second inlet buffer room 22 and the second outlet buffer room 24 maintain the negative pressure environment, but the pressure value is higher than the sample preparation room 21, so that the air flow can only flow into the sample preparation room 21 from the second inlet buffer room 22 and the second outlet buffer room 24 in one direction. The amplification and analysis room 31 and the third inlet buffer room 32 are all maintained in a negative pressure environment, and a pressure difference exists between the two areas, so that a value of the negative pressure environment of the amplification and analysis room 31 can be selected to be greater than a value of the negative pressure environment of the third inlet buffer room 32, the value of the negative pressure environment of the amplification and analysis room 31 can also be set to be smaller than the value of the negative pressure environment of the third inlet buffer room 32, and the value of the negative pressure environment of the amplification and analysis room 31 needs to be ensured to be greater than the value of the negative pressure environment of the decontamination room. The reagent preparation chamber 11 and the first inlet buffer chamber 12 may be in a positive pressure environment or a negative pressure environment, and a pressure difference exists between the two regions, so that the air flow can be set to flow in any direction between the two regions as required. One preferred specific pressure value setting may be: the ambient pressure value of the sample preparation room 21 is-30 Pa, the ambient pressure value of the second inlet buffer room 22 and the second outlet buffer room 23 is-10 Pa, the ambient pressure value of the decontamination room 23 is-15 Pa, the ambient pressure value of the amplification analysis room 31 is-20 Pa, and the ambient pressure value of the third inlet buffer room 32 is-25 Pa or-10 Pa; on the basis of this, the reagent preparation chamber 11 and the first inlet buffer chamber 12 can be set to any one of the following combinations of ambient pressure values: the ambient pressure value of the reagent preparation chamber 11 is 15Pa, the ambient pressure value of the first inlet buffer chamber 12 is 10Pa, the ambient pressure value of the reagent preparation chamber 11 is-5 Pa, the ambient pressure value of the first inlet buffer chamber 12 is-10 Pa, the ambient pressure value of the reagent preparation chamber 11 is 10Pa, the ambient pressure value of the first inlet buffer chamber 12 is 15Pa, the ambient pressure value of the reagent preparation chamber 11 is-10 Pa, and the ambient pressure value of the first inlet buffer chamber 12 is-5 Pa.
Preferably, the connecting doors adjacent to each region can be rotary airtight doors which are opened by rotating towards the side with higher environmental pressure, so that people can feel appropriate resistance formed by larger environmental pressure when opening the connecting doors, and meanwhile, the connecting doors can be pushed to rotate and close by utilizing the pressure difference between the environments.
The first entrance buffer room 12, the second entrance buffer room 22, the second exit buffer room 24 and the third entrance buffer room 32 may preferably provide a rest function for detecting people, such as a washroom, a bathroom, etc., in addition to providing necessary functions for people to change clothes, sterilize, etc.
The above description is only for the preferred embodiment of the present invention, but the protection scope of the present invention is not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention are also within the protection scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (8)
1. An integrated mobile laboratory system for pathogen nucleic acid detection comprising reagent storage and preparation stand-alone structures, specimen preparation stand-alone structures and amplification and product analysis stand-alone structures hermetically isolated from each other integrated within a mobile structure;
the reagent storage and preparation independent structure comprises a first inlet buffer room and a reagent preparation room which are connected in turn in an airtight way, and the side walls of the reagent preparation room are respectively provided with at least one airtight transmission window which is connected with the external environment and the sample preparation independent structure;
the sample preparation independent structure comprises a second inlet buffer room, a sample preparation room maintaining a negative pressure environment, a second outlet buffer room and a decontamination room which are connected in an airtight mode in sequence to form a one-way airtight personnel channel relative to the external environment, and the side wall of the sample preparation room is at least provided with an airtight transfer window connected with the external environment;
the independent amplification and product analysis structure comprises a third inlet buffer room and an amplification and analysis room maintaining a negative pressure environment which are connected in an airtight mode in sequence, and the side wall of the amplification and analysis room is provided with at least one airtight transfer window connected with the independent specimen preparation structure; the decontamination room is also provided with an airtight transfer window connected with the amplification analysis room;
and the negative pressure environmental pressure value of the sample preparation room is always lower than the environmental pressure values of other positions in the system.
2. The system of claim 1, further comprising a central control room and a power equipment room integrated within the same mobile structure in separate airtight isolation.
3. The system of claim 2, wherein the second inlet buffer room and the second outlet buffer room are maintained in a negative pressure environment, and a value of the negative pressure environment of the second outlet buffer room is higher than a value of the environmental pressure of the decontamination room; the negative pressure environmental pressure value of the amplification analysis room is higher than the environmental pressure value of the decontamination room, and a pressure difference exists between the amplification analysis room and the third inlet buffer room; a pressure differential exists between the reagent preparation compartment and the first inlet buffer compartment.
4. The system of claim 3, wherein an external power interface, a generator and a power distribution cabinet electrically connected with the reagent storage and preparation independent structure, the specimen preparation independent structure, the amplification and product analysis independent structure and the control room are arranged in the power equipment room, and an independent air conditioner outdoor unit is further arranged in the power equipment room; and a pressure monitoring device for collecting environmental pressure value data of the reagent storage and preparation independent structure, the sample preparation independent structure, the amplification and product analysis independent structure is arranged in the middle control room.
5. The system of claim 3, wherein the reagent preparation room is provided with a reagent storage device, an ultra clean bench for placing a reagent preparation instrument; an inactivation constant temperature box, a refrigeration refrigerator, a biological safety cabinet and a nucleic acid extractor are arranged in the sample preparation room; at least one PCR analyzer is arranged in the amplification analysis room; the decontamination room is provided with an autoclave and a waste garbage can.
6. The system of claim 1, wherein the first, second, and third entrance buffer compartments are each provided with a wardrobe.
7. The system of any one of claims 1 to 6, wherein the movable structure is a 45HQ format container.
8. The system of claim 7, wherein the container bottom is provided with mounting feet or a separate skid.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202021582829.4U CN212453801U (en) | 2020-08-03 | 2020-08-03 | Integrated mobile pathogen nucleic acid detection laboratory system |
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| CN202021582829.4U CN212453801U (en) | 2020-08-03 | 2020-08-03 | Integrated mobile pathogen nucleic acid detection laboratory system |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113944352A (en) * | 2021-11-03 | 2022-01-18 | 深圳市萨米医疗中心 | One-stop type nucleic acid collection gallery |
| CN114054120A (en) * | 2021-11-24 | 2022-02-18 | 哈尔滨星云医学检验所有限公司 | Laboratory automation system |
-
2020
- 2020-08-03 CN CN202021582829.4U patent/CN212453801U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113944352A (en) * | 2021-11-03 | 2022-01-18 | 深圳市萨米医疗中心 | One-stop type nucleic acid collection gallery |
| CN114054120A (en) * | 2021-11-24 | 2022-02-18 | 哈尔滨星云医学检验所有限公司 | Laboratory automation system |
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