CN213799396U - Movable nucleic acid detection vehicle - Google Patents
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- CN213799396U CN213799396U CN202022741703.3U CN202022741703U CN213799396U CN 213799396 U CN213799396 U CN 213799396U CN 202022741703 U CN202022741703 U CN 202022741703U CN 213799396 U CN213799396 U CN 213799396U
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Abstract
The utility model discloses a movable nucleic acid detecting vehicle, which comprises a nucleic acid detecting vehicle body; the nucleic acid detecting vehicle body is provided with a driving area and a laboratory area, the laboratory area is divided into three independent areas, namely a reagent preparation area, a sample preparation area and an amplification and product analysis area, the reagent preparation area, the sample preparation area and the amplification and product analysis area are respectively provided with an independent buffer room, and the side surface of the nucleic acid detecting vehicle body is provided with a safety access. The movable nucleic acid detection vehicle can be quickly, flexibly and flexibly transferred to a central area where epidemic situation outbreaks occur, so that people can collect and measure important groups immediately, the range of activity of the important groups is reduced, great convenience is brought to people, and for epidemic prevention units, patients can be quickly positioned by the short report period, and epidemic prevention efficiency is improved.
Description
Technical Field
The utility model relates to the fields such as pass catch disease screening and prevention and control, nucleic acid testing, this product mainly used novel coronavirus patient or the detection screening of infectant, or the detection of the sample of other accessible nucleic acid tests, exactly is movable nucleic acid testing car.
Background
The most important thing to deal with is to identify patients infected with viruses, i.e., to require nucleic acid detection. At present, the domestic nucleic acid detection is performed in part of qualified hospital laboratories or third-party medical examination laboratories, the laboratories are relatively fixed and concentrated in large-scale cities or regions, and many regions have no nucleic acid detection laboratories, are poor in detection capability and cannot cope with pressure caused by large-scale nucleic acid detection.
For the local area without a laboratory, the time for transporting the sample to the laboratory is generally one to two days after the sample is collected, the timeliness is poor, the rapid and accurate patient diagnosis is not facilitated, and the epidemic situation prevention and control are not facilitated. And because many labs that the epidemic situation was built can idle after the epidemic situation, cause huge wasting of resources, and nucleic acid detection car can be reasonable settle and save, when the epidemic situation takes place once more, can start fast.
SUMMERY OF THE UTILITY MODEL
The to-be-solved technical problem of the utility model is to the local area that does not have the laboratory, the sample is after gathering to the transportation generally needs one to two days time to the laboratory, and the ageing is relatively poor, is unfavorable for quick accurate patient of confirming, is unfavorable for epidemic situation prevention and control. And because many laboratories that the epidemic situation was built can idle after the epidemic situation, cause huge waste of resources.
In order to solve the above technical problem, the utility model discloses a following technical means:
the movable nucleic acid detection vehicle comprises a nucleic acid detection vehicle body; the nucleic acid detecting vehicle body is provided with a driving area and a laboratory area, the laboratory area is divided into three independent areas, namely a reagent preparation area, a sample preparation area and an amplification and product analysis area, the reagent preparation area, the sample preparation area and the amplification and product analysis area are respectively provided with an independent buffer room, and the side surface of the nucleic acid detecting vehicle body is provided with a safety access.
The movable nucleic acid detection vehicle can be quickly, flexibly and flexibly transferred to a central area where epidemic situation outbreaks occur, so that people can collect and measure important groups immediately, the range of activity of the important groups is reduced, great convenience is brought to people, and for epidemic prevention units, patients can be quickly positioned by the short report period, and epidemic prevention efficiency is improved.
Preferably, the present invention further provides:
the nucleic acid detection vehicle body is a bus with the length of standard 12 meters, a seat is arranged in a driving area, no seat is arranged in a laboratory area, a laboratory area is a P2-grade biological safety laboratory, a reagent preparation room in the laboratory area is arranged at the tail part of the nucleic acid detection vehicle body, the middle part in the laboratory area is a specimen preparation room, and the front end in the laboratory area is an amplification and product analysis room.
The device is characterized in that a partition wall is arranged between the driving area and the laboratory area, the laboratory area is divided into three independent areas by the partition wall, three buffer single rooms are divided by the partition wall in the three independent areas, and the three buffer single rooms are respectively a reagent preparation area, a reagent preparation area buffer room, a sample preparation area buffer room, an amplification and product analysis area buffer room, the size of the reagent preparation area buffer room, the size of the sample preparation area buffer room, the size of the amplification and product analysis area buffer room is 1435mm multiplied by 800mm, the width of an indoor door is 625mm, and a pedal type hand washing sink is arranged in each buffer room.
Safety access & exit including setting up the navigating instrument entry of handling regional side, laboratory zone one side is equipped with normal close formula emergency exit, normal close formula emergency exit is the access way and the escape way under the emergency of the great type instrument and equipment of biosafety cabinet, laboratory zone field one side is equipped with exit one and exit two, exit one is connected between reagent preparation district buffer, get into reagent preparation district through reagent preparation district buffer, exit two to left connect between sample preparation district buffer, get into sample preparation district through sample preparation district buffer, exit two to right connect between amplification and product analysis district buffer, get into amplification and product analysis district through amplification and product analysis district buffer, exit two places are equipped with public space.
The reagent preparation area is provided with a superclean bench and a refrigeration and freezing refrigerator, and the air pressure in the reagent preparation area is set to be positive pressure.
The area of the specimen preparation area occupies half of the area of a laboratory, and the specimen preparation area is provided with a B2 + level biological safety cabinet, a refrigeration and freezing refrigerator, an automatic extraction instrument and an autoclave, and the air pressure of the specimen preparation area is set to be negative pressure.
The amplification and product analysis area is provided with a fluorescence quantitative PCR instrument, an analysis computer, a printer and other instruments, and a DNA analysis area is arranged in the amplification and product analysis area.
The DNA analysis area is a DNA amplification analysis area, the DNA concentration is high, the pollution is strong, the area is negative pressure, the negative pressure is greater than the specimen preparation area, and pollutants are prevented from flowing into the specimen preparation area.
The reagent preparation area, the specimen preparation area and the amplification and product analysis area are provided with a transfer window of 500mm multiplied by 500mm between adjacent areas, and the specimen preparation area is provided with an external transfer window at one side of the nucleic acid detection vehicle body.
The laboratory area is provided with a UPS power supply system which mainly serves high-end precision instruments such as an automatic extraction instrument, a fluorescence quantitative PCR instrument and the like, the instruments are not affected by short-time power failure, and the nucleic acid detection vehicle body is provided with a 5G signal receiving and transmitting system and can be connected to a hospital or a disease control center network system.
The product adopts a 12-meter-long bus as a production basis, the interior of the product is built into a laboratory according to the standard of a clinical gene amplification laboratory, and the laboratory is divided into three regions: reagent preparation district, sample preparation district, amplification and product analysis district, every district all is equipped with the buffering room, and strict separation is in different areas, and every room is equipped with in independent ventilation system and the air conditioning system, ensures the inside pressure differential of laboratory, guarantees the air one-way flow, avoids laboratory nucleic acid "pollution". The experiment area is strictly separated from the driving area and the external environment, so that the release of toxic and harmful substances is avoided to pollute the environment, and the safety and health of external personnel are ensured.
Compared with a common clinical gene amplification laboratory, the detection vehicle is flexible, can be quickly transferred to an epidemic situation occurrence core area, only needs to level the field in the open air, ensures water and electricity supply, can quickly carry out detection work, simultaneously avoids the waste of time in the way of sample transportation, avoids unpredictable dangerousness in the way of transportation, and has outstanding advantages in dealing with regional sudden public health events.
The product solves the problem that no nucleic acid detection laboratory is present in part of regions, especially in part of epidemic situation outbreak places, the construction of a common nucleic acid detection laboratory generally needs one to three months, the period is long, the local real-time requirements cannot be met, and the powerful support cannot be timely provided for epidemic situation prevention and control.
Drawings
Fig. 1 is a schematic structural diagram of an embodiment of the present invention.
FIG. 2 is a schematic diagram of the structure of the amplification and product analysis region of the present invention.
FIG. 3 is a schematic structural view of the reagent preparation area and the specimen preparation area of the present invention.
Description of reference numerals: 1-a steering area; 2-a dividing wall; 3-buffer between amplification and product analysis zones; 4-a public space; 5-a sample preparation area buffer room; 6-normally closed safety door; 7-reagent preparation buffer compartment.
Detailed Description
The present invention will be further described with reference to the following examples.
Referring to fig. 1, the movable nucleic acid detecting vehicle of the present invention includes a nucleic acid detecting vehicle body; the nucleic acid detecting vehicle body is provided with a driving area and a laboratory area, the laboratory area is divided into three independent areas which are respectively a reagent preparation area, a specimen preparation area and an amplification and product analysis area, the reagent preparation area, the specimen preparation area and the amplification and product analysis area are respectively provided with a single buffer room, the side surface of the nucleic acid detecting vehicle body is provided with a safety access, the nucleic acid detecting vehicle body is a bus of which the length is nearly 12 meters, a seat is arranged in the driving area, the laboratory area is not provided with a seat, the laboratory area is a P2-grade biosafety laboratory, a reagent preparation room in the laboratory area is arranged at the tail part of the nucleic acid detecting vehicle body, the middle part in the laboratory area is a specimen preparation room, the front end in the laboratory area is an amplification and product analysis room, a partition wall is arranged between the driving area and the laboratory area, and the laboratory area is divided into three independent areas by the partition wall, the three independent areas are divided into three buffer single rooms by partition walls, namely a reagent preparation area, a reagent preparation area buffer room, a specimen preparation area buffer room, an amplification and product analysis area and an amplification and product analysis area buffer room, wherein the sizes of the reagent preparation area buffer room, the specimen preparation area buffer room and the amplification and product analysis area buffer room are 1435mm multiplied by 800mm, the width of an indoor door is 625mm, and a pedal-type hand washing pool is arranged in each buffer room.
Specific example 2:
referring to fig. 1, the movable nucleic acid detecting vehicle of the present invention includes a nucleic acid detecting vehicle body; the nucleic acid detecting vehicle body is provided with a driving area and a laboratory area, the laboratory area is divided into three independent areas which are respectively a reagent preparation area, a specimen preparation area, an amplification and product analysis area, the reagent preparation area, the specimen preparation area, the amplification and product analysis area are respectively provided with an independent buffer room, the side surface of the nucleic acid detecting vehicle body is provided with a safety entrance, the safety entrance comprises a driver entrance arranged on the side surface of the driving area, one side of the laboratory area is provided with a normally closed safety door which is an entrance and exit channel of a large instrument and equipment of a biological safety cabinet and an escape channel under emergency, one side of the field of the laboratory area is provided with an entrance and exit I and an exit II, the entrance and exit I is connected with the buffer room of the reagent preparation area, the entrance and the exit are connected with the buffer room of the specimen preparation area in the left direction, the sample preparation area enters the sample preparation area through the sample preparation area buffer space, the inlet and the outlet are connected with the amplification and product analysis area buffer space in the right direction, the amplification and product analysis area enters the amplification and product analysis area through the amplification and product analysis area buffer space, and a public space is arranged at the inlet and the outlet.
Specific example 3:
referring to fig. 1, the movable nucleic acid detecting vehicle of the present invention includes a nucleic acid detecting vehicle body; the nucleic acid detecting vehicle body is provided with a driving area and a laboratory area, the laboratory area is divided into three independent areas which are a reagent preparation area, a specimen preparation area and an amplification and product analysis area respectively, the reagent preparation area, the specimen preparation area and the amplification and product analysis area are provided with independent buffer rooms, the side surface of the nucleic acid detecting vehicle body is provided with a safety access, the reagent preparation area is provided with an ultra-clean workbench and a refrigerating and freezing refrigerator, the air pressure in the reagent preparation area is set to be positive pressure, the area of the specimen preparation area accounts for half of the area of the laboratory area, the nucleic acid detecting vehicle body is provided with a B2 + level biological safety cabinet, a refrigerating and freezing refrigerator, an automatic extractor and a high-pressure sterilization pot, the air pressure in the specimen preparation area is set to be negative pressure, the amplification and product analysis area is provided with instruments such as a fluorescence quantitative PCR instrument, an analysis computer and a printer, and the like, and the amplification and product analysis area is internally provided with a DNA analysis area, the DNA analysis area is a DNA amplification analysis area, the DNA concentration is higher, the pollution is stronger, so the area is negative pressure, the negative pressure is larger than that of the specimen preparation area, the pollutants are prevented from flowing into the specimen preparation area, a transmission window of 500mm multiplied by 500mm is installed between adjacent areas of the reagent preparation area, the specimen preparation area and the amplification and product analysis area, the specimen preparation area is provided with an external transmission window at one side of the nucleic acid detection vehicle body, the laboratory area is provided with a UPS power supply system which mainly serves high-end precision instruments such as an automatic extraction instrument and a fluorescence quantitative PCR instrument, the instrument is prevented from being influenced by short-time power failure, and the nucleic acid detection vehicle body is provided with a 5G signal receiving and transmitting system and can be connected to a hospital or a disease control center network system.
Specific example 4:
referring to fig. 1, the overall structure of the mobile nucleic acid detecting vehicle of the present invention is described:
the automobile main body structure: a standard 12-meter-long bus is provided, seats are not arranged in other areas except a driver's cabin, and an original passenger cabin is decorated into a P2-grade biological safety laboratory.
The main structure of the laboratory: the rear area of the cockpit is built into a laboratory part which is divided into six rooms, namely a three-room buffer room and a three-room laboratory; the laboratory partitions are arranged from back to front of the vehicle, the reagent preparation chamber is arranged at the rearmost, the specimen preparation chamber is arranged in the middle, the amplification and product analysis chamber is arranged at the front end, and each laboratory is provided with an independent buffer chamber.
The 'import and export one' is an import and export of the reagent preparation chamber and the buffer chamber, the buffer chamber is formed after the car body hatch door enters, the size of the buffer chamber is 1435mm multiplied by 800mm, the width of the indoor door is 625mm, and a pedal type hand washing sink is arranged in the buffer chamber. [0030] Get into reagent preparation district inwards between by the buffering of "exit one" entering, this region is equipped with instrument and equipment such as superclean bench, cold-stored freezing refrigerator, and air pressure sets up to the malleation in the laboratory, and the air is from inside to outside diffusion, avoids the pollutant to get into indoorly along with the air, guarantees the cleanness in this region. The main function of this zone is the configuration and storage of the test reagents.
The second inlet and outlet is a public access passage of the two latter laboratories, the car body cabin door is a public platform (corridor) after entering, the area enters the buffer room of the specimen preparation area or the amplification and product analysis area respectively leftwards or rightwards, the two buffer rooms are similar to the buffer room of the reagent preparation area, and the size of the indoor door is the same.
Enters the specimen preparation area from the entrance and the exit to the left, the total area of the area accounts for about half of the total area of a laboratory, and the specimen preparation area is provided with instruments and equipment such as a B2 + grade biological safety cabinet, a refrigeration and freezing refrigerator, an automatic extraction instrument, an autoclave and the like. The air pressure in the area is set to be negative pressure, so that pollutants in the area are prevented from flowing out along with the air. The main functions of this region are the pretreatment of the specimen and the mixing of reagents and specimen.
Enter right from "exit two" and get into amplification and product analysis district promptly, this region is equipped with instrument and equipment such as fluorescence quantitative PCR appearance, analysis computer, printer, and this region is the region of DNA amplification analysis, and DNA concentration is higher, and the pollution nature is stronger, so this region is the negative pressure, and the pollutant can not flow out along with the air, avoids polluting other environment, and the negative pressure is greater than the sample preparation district, avoids the pollutant to flow into the prozone.
A transfer window of 500mm multiplied by 500mm is arranged between adjacent laboratories for transferring reagents, experimental samples and the like; the specimen preparation area and the outside of the vehicle body are provided with a transfer window which is used as a sample receiving channel, and a sample received at the outside enters the interior of the laboratory through the channel.
The left side of the specimen preparation area is provided with a normally closed safety door which can be used as an access passage of larger instruments such as a biological safety cabinet and the like and also used as an escape passage in emergency.
The whole laboratory is provided with a UPS power supply system which mainly serves high-end precision instruments such as an automatic extraction instrument, a fluorescence quantitative PCR instrument and the like, and the instruments are not influenced by short-time power failure.
The whole vehicle is provided with a 5G signal receiving and transmitting system, can be interconnected with the outside, and can be connected to network systems such as hospitals, disease control centers and the like.
The product can realize the detection of 4000-6000-sample per day, effectively improves the nucleic acid detection capability of the region, and saves at least 2 hours of report time along with acquisition and detection.
Specific example 5:
a dividing wall strictly separating the cab from the laboratory;
a buffer compartment in the amplification and product analysis zone through which the amplification and product analysis zone is accessible;
a common space entering a common area between the buffers at both sides;
a buffer compartment in the specimen preparation area through which the specimen preparation area is accessible;
the normally closed safety door can be used as an access way of large-scale equipment, also is an escape way in emergency and is normally closed;
a reagent preparation area buffer compartment through which the reagent preparation area is accessible;
the advantages of the mobile nucleic acid detection vehicle compared with the traditional nucleic acid detection laboratory are as follows:
the effectiveness is good: when the epidemic situation takes place, portable nucleic acid detects the car and can transfer to the epidemic area fast and carry out the detection work, has better effect to the epidemic situation control.
The benefits are good: when the epidemic situation occurs, a large number of laboratories need to be built, and after the epidemic situation occurs, a large number of laboratories are idle, so that waste is caused. The mobile nucleic acid detection vehicle solves the problem on the premise of meeting the breaking requirement, and can be started when needed by proper storage when actually needing to be idle.
And (3) reducing the propagation range: the mobile nucleic acid detection vehicle is used in an epidemic area, so that the flow of a patient is reduced, and the propagation path and time of viruses are reduced.
Reducing sample circulation time: in a local place without a nucleic acid detection laboratory, the flow of the experimental sample may take 1-2 days, and the accuracy and the timeliness of the detection are greatly influenced.
Since the above description is only a specific embodiment of the present invention, but the protection of the present invention is not limited thereto, any person skilled in the art can think of equivalent changes or substitutions of the technical features of the present invention, and all are covered in the protection scope of the present invention.
Claims (10)
1. The movable nucleic acid detection vehicle comprises a nucleic acid detection vehicle body; the method is characterized in that: the nucleic acid detecting vehicle body is provided with a driving area and a laboratory area, the laboratory area is divided into three independent areas, namely a reagent preparation area, a sample preparation area and an amplification and product analysis area, the reagent preparation area, the sample preparation area and the amplification and product analysis area are respectively provided with an independent buffer room, and the side surface of the nucleic acid detecting vehicle body is provided with a safety access.
2. The mobile nucleic acid detecting vehicle according to claim 1, wherein: the nucleic acid detection vehicle body is a bus with the length of standard 12 meters, a seat is arranged in a driving area, no seat is arranged in a laboratory area, a laboratory area is a P2-grade biological safety laboratory, a reagent preparation room in the laboratory area is arranged at the tail part of the nucleic acid detection vehicle body, the middle part in the laboratory area is a specimen preparation room, and the front end in the laboratory area is an amplification and product analysis room.
3. The mobile nucleic acid detecting vehicle according to claim 1, wherein: the device is characterized in that a partition wall is arranged between the driving area and the laboratory area, the laboratory area is divided into three independent areas by the partition wall, three buffer single rooms are divided by the partition wall in the three independent areas, and the three buffer single rooms are respectively a reagent preparation area, a reagent preparation area buffer room, a sample preparation area buffer room, an amplification and product analysis area buffer room, the size of the reagent preparation area buffer room, the size of the sample preparation area buffer room, the size of the amplification and product analysis area buffer room is 1435mm multiplied by 800mm, the width of an indoor door is 625mm, and a pedal type hand washing sink is arranged in each buffer room.
4. The mobile nucleic acid detecting vehicle according to claim 1, wherein: safety access & exit including setting up the navigating instrument entry of handling regional side, laboratory zone one side is equipped with normal close formula emergency exit, normal close formula emergency exit is the access way and the escape way under the emergency of the great type instrument and equipment of biosafety cabinet, laboratory zone field one side is equipped with exit one and exit two, exit one is connected between reagent preparation district buffer, get into reagent preparation district through reagent preparation district buffer, exit two to left connect between sample preparation district buffer, get into sample preparation district through sample preparation district buffer, exit two to right connect between amplification and product analysis district buffer, get into amplification and product analysis district through amplification and product analysis district buffer, exit two places are equipped with public space.
5. The mobile nucleic acid detecting vehicle according to claim 1, wherein: the reagent preparation area is provided with a superclean bench and a refrigeration and freezing refrigerator, and the air pressure in the reagent preparation area is set to be positive pressure.
6. The mobile nucleic acid detecting vehicle according to claim 1, wherein: the area of the specimen preparation area occupies half of the area of a laboratory, and the specimen preparation area is provided with a B2 + level biological safety cabinet, a refrigeration and freezing refrigerator, an automatic extraction instrument and an autoclave, and the air pressure of the specimen preparation area is set to be negative pressure.
7. The mobile nucleic acid detecting vehicle according to claim 1, wherein: the amplification and product analysis area is provided with a fluorescence quantitative PCR instrument, an analysis computer and a printer, and a DNA analysis area is arranged in the amplification and product analysis area.
8. The mobile nucleic acid detecting vehicle according to claim 7, wherein: the DNA analysis area is a DNA amplification analysis area, the DNA concentration is higher, the pollution is stronger, so the area is negative pressure, and the negative pressure is greater than the specimen preparation area, thereby avoiding pollutants from flowing into the specimen preparation area.
9. The mobile nucleic acid detecting vehicle according to claim 1, wherein: the reagent preparation area, the specimen preparation area and the amplification and product analysis area are provided with a transfer window of 500mm multiplied by 500mm between adjacent areas, and the specimen preparation area is provided with an external transfer window at one side of the nucleic acid detection vehicle body.
10. The mobile nucleic acid detecting vehicle according to claim 1, wherein: the laboratory area is provided with a UPS power supply system which mainly serves an automatic extraction instrument and a fluorescence quantitative PCR instrument and ensures that the instruments are not influenced by short-time power failure, and the nucleic acid detection vehicle body is provided with a 5G signal receiving and transmitting system which can be connected to a hospital or a disease control center network system.
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| CN202022741703.3U CN213799396U (en) | 2020-11-24 | 2020-11-24 | Movable nucleic acid detection vehicle |
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| CN202022741703.3U CN213799396U (en) | 2020-11-24 | 2020-11-24 | Movable nucleic acid detection vehicle |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113605745A (en) * | 2021-08-10 | 2021-11-05 | 重庆两江新区第一人民医院 | Double-channel high-low risk pathogenic microorganism nucleic acid detection laboratory |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113605745A (en) * | 2021-08-10 | 2021-11-05 | 重庆两江新区第一人民医院 | Double-channel high-low risk pathogenic microorganism nucleic acid detection laboratory |
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