CN215162569U - Combined type experiment platform capable of continuously operating - Google Patents
Combined type experiment platform capable of continuously operating Download PDFInfo
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Abstract
The combined type experiment platform capable of continuously running is characterized by comprising a reagent preparation module, a sample processing module and an amplification detection module which are sequentially arranged; the reagent preparation module is used for constructing a channel for the detection reagent and auxiliary materials to enter from the external space; the sample processing module is used for constructing a space for uniformly mixing and subpackaging the reagent and the biological sample; the amplification detection module is used for constructing a space for detecting a biological detection sample; the first transmission window is internally arranged to enable air to be sucked and is kept to operate under a negative pressure working condition relatively lower than the internal pressure of the second main internal space; the second transmission window is arranged in a manner that air can be sucked and is kept to operate under a negative pressure working condition relatively lower than the internal pressure of the second main inner space; and the third transfer window is arranged to enable air to be sucked and is kept to operate under a negative pressure working condition relatively lower than the internal pressure of the second main inner space and the third main inner space.
Description
Technical Field
The invention relates to the technical field of biological sample treatment and detection, in particular to a combined type experiment platform which integrates biological sample treatment and PCR detection and can continuously run and a management method thereof.
Background
Currently, apparatuses for processing and detecting biological samples using reagents, such as chinese patent application No. 201810468593.2 entitled "integrated biological sample processing and detecting device and method thereof", disclose that a nucleic acid extraction module, a reaction system construction module, and a nucleic acid detection module are disposed in one case, and the probability of cross-contamination is reduced by providing a double-pass isolation door and a buffer zone between adjacent modules. When the biological sample carrier is moved, the scheme also provides a mode of replacing manual operation by a mechanical arm component, so that the conditions of disease sample mixing and cross contamination are reduced on one hand, the whole structure of the device is favorably optimized on the other hand, and the technical problem of cross contamination caused by mutual influence of sample piece aerosol, liquid droplets and the like when the nucleic acid extraction module, the reaction system construction module and the nucleic acid detection module are combined into one device is solved.
However, tests show that, because the nucleic acid extraction module, the reaction system construction module, the nucleic acid detection module and the double-channel isolation door and the buffer area arranged between the adjacent modules of the device are operated under a negative pressure working condition or partially operated under a negative pressure working condition, auxiliary materials such as detection reagents, instruments and tools and the like fed in at the early stage of an experiment or in the process of the experiment also need to be combined with a biological sample and enter a detection flow through the nucleic acid extraction module, dust and possibly entrained bacteria, viruses and the like adhered to the auxiliary materials such as the reagents, the instruments and the like can be mixed into a detection flow pollution reagent and the sample, and when the final amplification detection is carried out, too many impurities are found, so that the confusion is easy, the detection difficulty is greatly increased, the detection efficiency is reduced, and even misjudgment is caused. Secondly, although the nucleic acid extraction module, the reaction system construction module, the nucleic acid detection module and the double-channel isolation door and the buffer area arranged between the adjacent modules of the device are operated under the negative pressure working condition, not only can the cross infection between different modules not be prevented, but also the device can overflow, so that the device can cause the influence of dust in the external space and possibly carried bacteria and viruses on the experimental result if the device is operated under the continuous detection, and obviously, the device is not allowed in the PCR detection, thereby needing improvement.
Disclosure of Invention
In order to overcome the defects of the prior art, and to reduce the risk of cross contamination of biological samples and the influence of external pollutants on experimental results, the invention provides a safe, reliable and continuously working biological detection experimental platform, which is characterized by comprising a reagent preparation module, a sample processing module and an amplification detection module which are sequentially arranged; wherein,
the reagent preparation module is used for constructing a channel for the reagent for detection and auxiliary materials to enter from an external space, and comprises a first operation platform, a first main inner space arranged above the first operation platform and a first operation window communicated with the first main inner space, wherein the first main inner space is arranged to receive clean air blown from the top of the first main inner space and can keep positive pressure operation;
the sample processing module is used for constructing a space for uniformly mixing and subpackaging a reagent and a biological sample, and comprises a second operation platform, a second main inner space arranged on the second operation platform and a second operation window communicated with the second main inner space, wherein a second window door with a light transmission function is arranged at the second operation window, and the second main inner space is arranged in a manner that air can be sucked to keep running under a negative pressure working condition;
the amplification detection module is used for constructing a space for detecting biological detection samples, and comprises a third operation platform, a third main inner space arranged above the third operation platform and a third operation window communicated with the third main inner space, wherein a third window door with a light transmission function is arranged at the third operation window, and the third main inner space is arranged in a manner that air can be sucked to keep running under a negative pressure working condition;
the first transmission window comprises two first door leaves which are locked with each other and is used for enabling a first in-box space in the first transmission window to be selectively communicated with the first main inner space and the second main inner space through the two first door leaves which are locked with each other; the first transfer window is internally arranged to enable air to be sucked and is kept to operate under a negative pressure working condition relatively lower than the internal pressure of the second main internal space;
the second transfer window comprises two second door leaves which are mutually locked, and is used for realizing selective communication between a second in-box space in the second transfer window and an external space as well as between a second main internal space through the two second door leaves which are mutually locked; the second transfer window is arranged to enable air to be sucked and is kept to operate under a negative pressure working condition relatively lower than the internal pressure of the second main internal space;
the third transfer window comprises two third door leaves which are mutually locked, and is used for realizing selective communication between a third box inner space in the third transfer window and the second main inner space and the third main inner space through the two third door leaves which are mutually locked; the third transfer window is arranged to allow air to be sucked and is maintained to operate at a negative pressure relatively lower than the internal pressures of the second and third main internal spaces.
The invention also provides a combined experimental platform management method capable of continuously running, which is characterized by comprising a reagent preparation module, a sample processing module and an amplification detection module which are sequentially arranged; wherein,
the reagent preparation module comprises a first operation platform, a first main inner space arranged above the first operation platform and a first operation window communicated with the first main inner space, a channel for the detection reagent and auxiliary materials to enter from an external space is constructed by the reagent preparation module, clean air enters the first main inner space from top to bottom, and the air pressure working condition in the first main inner space is kept to be positive pressure;
the sample processing module comprises a second operation platform, a second main inner space arranged on the second operation platform and a second operation window communicated with the second main inner space, a second window door with a light transmission function is arranged at the second operation window, the sample processing module is used for constructing a space for uniformly mixing and subpackaging a reagent and a biological sample, and air in the second main inner space is pumped to ensure that the air pressure working condition in the second main inner space is negative pressure;
the amplification detection module comprises a third operation platform, a third main inner space arranged on the third operation platform and a third operation window communicated with the third main inner space, wherein a third window door with a light transmission function is arranged at the third operation window, the amplification detection module is used for constructing a biological detection sample detection space, and air in the third main inner space is pumped to ensure that the air pressure working condition in the third main inner space is negative pressure;
the first transmission window comprises two first door leaves which are locked with each other and is used for enabling a first in-box space in the first transmission window to be selectively communicated with the first main inner space and the second main inner space through the two first door leaves which are locked with each other; pumping air in the first transmission window to enable the air pressure working condition in the first transmission window to be negative pressure and relatively lower than the internal pressure of the second main internal space;
the second transfer window comprises two second door leaves which are mutually locked, and is used for realizing selective communication between a second in-box space in the second transfer window and an external space as well as between a second main internal space through the two second door leaves which are mutually locked; air in the second transfer window is sucked to enable the air pressure working condition in the second transfer window to be negative pressure and relatively lower than the internal pressure of the second main inner space;
the third transfer window comprises two third door leaves which are mutually locked, and is used for realizing selective communication between a third box inner space in the third transfer window and the second main inner space and the third main inner space through the two third door leaves which are mutually locked; and sucking air in the third transfer window to enable the air pressure working condition in the third transfer window to be negative pressure and to be relatively lower than the internal pressure of the second main inner space and the third main inner space.
The reagent preparation module is used for transmitting detection test auxiliary materials such as reagents for experiments and auxiliary materials and the like, and comprises a first main inner space, wherein related reagents, auxiliary materials, a blending instrument, disinfectors and the like (but not including collecting biological samples to be detected) required by the operation of the process and the subsequent process can be contained in the first main inner space and put into a first transmission window by virtue of the first main inner space, and the first main inner space can be kept to operate under a positive pressure working condition higher than the atmospheric pressure in a clean environment, so that pollutants can be blown away, any drifts in the first transmission window can be strongly limited to be leaked out, and the first guarantee and safety can be provided for continuous experiments; the sample processing module is used for the operations of uniformly mixing and subpackaging reagents and biological samples and the like, comprises a second main inner space and can be operated under the negative pressure working condition lower than the atmospheric pressure, so that the reagent or the biological sample which possibly escapes during the experiment operation in the second main inner space can be prevented from drifting to the first main inner space; the amplification detection module is used for amplifying and detecting biological detection samples and the like, comprises a third main inner space, can operate under the negative pressure working condition, and further can operate under the internal pressure relatively lower than that of the second main inner space. The biological sample refers to a biological sample which is sent for detection and is not chemically inactivated, and the detection sample refers to a biological sample which is subjected to inactivation measures.
The first transfer window comprises a first in-box space and two mutually-locked door leaves, is used for transferring experimental materials such as reagents and instruments in the first main inner space to the second main inner space, and operates under a negative pressure working condition relatively lower than the internal pressure of the second main inner space, and the internal air pressure of the first transfer window is certainly lower than the internal pressure of the first main inner space so as to isolate a floater conduction path between the second main inner space and the first main inner space, reduce cross contamination between the second main inner space and the first main inner space and improve safety; the second transmission window comprises a second in-box space and two mutually-locked door leaves and is used for transmitting the biological samples in the external space to the second main internal space and operates under the negative pressure working condition that the internal pressure of the second main internal space is relatively lower than that of the second main internal space so as to separate the floater conduction paths between the second main internal space and the external space, so that the cross contamination between the second main internal space and the external space is reduced and the safety is improved; the third transfer window comprises a third in-box space and two mutually-locked door leaves and is used for transferring the prepared detection sample in the second main inner space to the third main inner space and operating under the negative pressure working condition relatively lower than the internal pressure of the second main inner space and the third main inner space so as to separate the floater conduction path between the second main inner space and the third main inner space, thereby reducing the cross contamination between the second main inner space and the third main inner space and improving the safety.
According to the structure and the method, the internal pressure gradient is established between the main inner space and the transfer window, two different input channels are established, and the third main inner space detected finally still keeps a negative pressure working condition and the like, the structures and the methods independently play respective roles and also have synergistic effects, and the beneficial technical effects are achieved that firstly, due to the fact that the reagent preparation module is arranged and the interior of the reagent preparation module runs in a clean environment in a positive pressure mode, not only can pollutants be blown away, but also the pollution of reagents, instruments, auxiliary materials and the like used for the test by dust and bacteria in the air can be greatly reduced, the detection result is influenced, in addition, the leakage of any drifted objects in the first transfer window can be powerfully limited, and the first guarantee and the safety are provided for continuous experiments; secondly, the first transfer window is arranged and operates under the negative pressure working condition that the internal pressure of the first main inner space is lower than that of the second main inner space, so that the drift propagation path of the microorganism is cut off, and a second guarantee and safety are provided for continuous experiments; thirdly, due to the fact that the second transfer window is arranged and operates under the negative pressure working condition that the internal pressure of the second main inner space is lower than that of the second main inner space, the material for inspection and the biological sample enter the second main inner space through different channels, the drift propagation path of the microorganism is cut off, the first transfer window and the second transfer window cooperate to form two input paths, and third guarantee and safety are provided for continuous experiments; fourthly, the third transfer window is arranged and operates under the negative pressure working condition that the internal pressure of the third transfer window is lower than that of the second main inner space and that of the third main inner space, so that the drift propagation path of the microorganism is cut off, and a fourth guarantee and safety are provided for continuous experiments; fifth, compared with the prior art, the method greatly reduces the risk of cross contamination of the biological samples and the influence of external pollutants on the experimental results.
The invention has the characteristics and advantages, so the invention can be applied to a combined type experiment platform capable of continuously running.
Drawings
FIG. 1 is a schematic plan layout of an experimental platform to which the scheme of the present invention is applied;
FIG. 2 is a schematic diagram of an exploded layout of an experimental platform to which the scheme of the present invention is applied;
FIG. 3 is a schematic diagram of the front side of the composite structure of the experimental platform applying the scheme of the present invention;
FIG. 4 is a rear view of the composite structure of the experimental platform to which the present invention is applied;
Detailed Description
The structure and method of the experimental platform applying the scheme of the invention are further described with reference to the accompanying drawings 1-4.
In order to reduce the risk of cross contamination of biological samples and the influence of external pollutants on experimental results, and to construct a safe, reliable and continuously operable biological PCR detection experimental platform, as shown in fig. 1 to 4, this embodiment first discloses a continuously operable combined experimental platform 100, which includes a reagent preparation module 1, a sample processing module 2, and an amplification detection module 3, which are arranged in the order of left, right, and the first transfer window 4, the second transfer window 5, and the third transfer window 6 for material transportation; the reagent preparation module 1, the sample processing module 2, and the amplification and detection module 3 may be arranged closely to each other, or may be spaced apart from each other, as long as the internal spaces thereof can communicate with each other through the first transmission window 4 and the third transmission window 6. The reagent preparation module 1 is used for constructing a passage for the detection reagent and auxiliary materials to enter from an external space, and comprises a first operation platform 101, a first main internal space 12 arranged above the first operation platform 101 and a first operation window communicated with the first main internal space 12, wherein the first main internal space 12 is arranged to receive clean air blown from the top of the first main internal space and can keep positive pressure operation;
the sample processing module 2 is used for constructing a space for uniformly mixing and subpackaging reagents and biological samples, and comprises a second operation platform 201, a second main inner space 22 arranged on the second operation platform 201, and a second operation window communicated with the second main inner space 22, wherein a second window 23 with a light transmission function is arranged at the second operation window, and the second main inner space 22 is arranged such that air can be sucked to keep running under a negative pressure working condition;
the amplification detection module 3 is used for constructing a space for detecting a biological detection sample, and comprises a third operation platform 301, a third main inner space 32 arranged above the third operation platform 301, and a third operation window communicated with the third main inner space, wherein a third window door 33 with a light transmission function is arranged at the third operation window, and the third main inner space 32 is arranged to be capable of being sucked to operate under a negative pressure condition;
the first transfer window 4 comprises two first door leaves 40 which are mutually locked, and is used for realizing selective communication between the first in-box space in the first transfer window 4 and the first main inner space 12 and the second main inner space 22 through the two first door leaves 40 which are mutually locked; the first transfer window 4 is arranged such that air can be sucked in, and is kept operating at a negative pressure relatively lower than the internal pressure of the second main internal space 22;
the second delivery window 5 comprises two second doors 50 which are mutually locked, and the second delivery window 5 is used for enabling the second in-box space in the second delivery window 5 to be selectively communicated with the external space and the second main internal space 22 through the two second doors 50 which are mutually locked; the second transfer window 5 is arranged such that air can be sucked in, and is kept operating under a negative pressure condition relatively lower than the internal pressure of the second main internal space 22;
the door further comprises a third transfer window 6, which comprises two third door leaves 60 locked with each other, and is used for realizing selective communication between a third in-box space in the third transfer window 6 and the second main internal space 22 and the third main internal space 32 through the two third door leaves 60 locked with each other; the third transfer window 6 is arranged such that air can be sucked and kept in operation at a negative pressure relatively lower than the internal pressure of the second main internal space 22, the third main internal space 32.
Secondly, the embodiment also discloses a combined type experiment platform management method capable of continuously running, which comprises a reagent preparation module 1, a sample processing module 2 and an amplification detection module 3 which are sequentially arranged; wherein,
constructing a passage for a detection reagent and an auxiliary material to enter from an external space by using the reagent preparation module 1, wherein the reagent preparation module 1 comprises a first operation platform 101, a first main internal space 12 arranged above the first operation platform 101 and a first operation window communicated with the first main internal space 12, so that clean air enters the first main internal space 12 from the top to the bottom direction, and the air pressure condition in the first main internal space 12 is kept to be positive pressure;
a space for uniformly mixing and subpackaging the reagent and the biological sample is constructed by using the sample processing module 2, the sample processing module 2 comprises a second operation platform 201, a second main inner space 22 arranged on the second operation platform 201 and a second operation window communicated with the second main inner space 22, a second window door 23 with a light transmission function is arranged at the second operation window, and air in the second main inner space 22 is pumped to ensure that the air pressure working condition in the second main inner space 22 is negative pressure;
constructing a space for detecting a biological detection sample by using the amplification detection module 3, wherein the amplification detection module 3 comprises a third operation platform 301, a third main inner space 32 arranged above the third operation platform 301, and a third operation window communicated with the third main inner space 32, a third window door 33 with a light transmission function is arranged at the third operation window, and air in the third main inner space 32 is pumped to make the air pressure working condition in the third main inner space 32 be negative pressure;
the first transfer window 4 comprises two first door leaves 40 which are mutually locked, and is used for realizing selective communication between the first in-box space in the first transfer window 4 and the first main inner space 12 and the second main inner space 22 through the two first door leaves 40 which are mutually locked; the air in the first transfer window 4 is sucked to enable the air pressure working condition in the first transfer window 4 to be negative pressure and relatively lower than the internal pressure of the second main internal space 22;
the second delivery window 5 comprises two second doors 50 which are mutually locked, and the second delivery window 5 is used for enabling the second in-box space in the second delivery window 5 to be selectively communicated with the external space and the second main internal space 22 through the two second doors 50 which are mutually locked; the air in the second transfer window 5 is sucked to make the air pressure working condition in the second transfer window 5 be negative pressure and relatively lower than the internal pressure of the second main internal space 22;
the door further comprises a third transfer window 6, which comprises two third door leaves 60 locked with each other, and is used for realizing selective communication between a third in-box space in the third transfer window 6 and the second main internal space 22 and the third main internal space 32 through the two third door leaves 60 locked with each other; the air in the third transfer window 6 is sucked to make the air pressure in the third transfer window 6 negative and relatively lower than the internal pressure of the second main internal space 22 and the third main internal space 32.
The PCR experiment is also called gene amplification experiment. PCR is a short term for Polymerase Chain Reaction (Polymerase Chain Reaction), a molecular biology technique used to amplify specific DNA fragments and can be used as a special DNA copy in vitro. The virus content in the body of a patient can be rapidly mastered by a DNA gene tracking system, and the accuracy of the system reaches the nanometer level. For this reason, firstly, an experimental device and a platform with higher safety are needed for carrying out the experiment, and secondly, the relevant reagents and samples cannot be polluted, so that the accuracy of the experimental result is ensured. Each of the specific implementation details, structures and methods disclosed below are described in detail as being necessary, and in addition to the specific descriptions pertaining to equivalent or alternative embodiments, the various implementation details disclosed below may be used selectively or combined in one embodiment, even if not directly related or synergistic in functional terms.
As shown in fig. 2 and 3, the reagent preparation module 1 includes a first frame body 10, a first operation platform 101 and a first main internal space 12 disposed above the first operation platform 101 are constructed in the first frame body 10, a first operation window and a first window door 13 communicated with the first main internal space 12 are disposed at a front side of the first frame body 10, the first window door 13 can move up and down to open or close the first operation window, and an experimenter can open or close the first window door 13 at any time according to work needs. The height of the first operation platform 101 of the first main internal space 12 is suitable for the operation of the experimenter. A germicidal lamp and an illumination lamp (not visible in the first frame 10 shown in fig. 2) are also mounted on the upper wall or the side walls of the first main internal space 12. Casters are further provided under the first frame 10 to facilitate movement (note, the casters are omitted in fig. 3 and 4). The reagent preparation module 1 is a self-contained frame-type device which can be manufactured separately, packaged, transported to the site and then assembled with other module devices.
The reagent preparation module 1, also referred to as a reagent preparation workbench or a positive pressure superclean workbench, can be stored in the first main internal space 12 or put in the first transfer window 4 by the first main internal space 12, so that materials required for an experiment can be collected at any time by the first main internal space 12 of the reagent preparation module 1 even in an experiment of the sample processing module 2, and a passage for a detection reagent and an auxiliary material to enter from an external space is constructed.
Also comprises a first main control unit 11 used for managing the air pressure working condition in the first main inner space 12 and comprising a first main pressure regulating system, the first main pressure regulating system refers to the entire path of passage that air takes from the outside space into the first main inner space 12, in the path (i.e., the first main pressure regulating system), a first fan and a first purifying unit (not visible in the first frame 10 shown in fig. 2) and a connecting pipe communicating the front and rear ends of the first fan and the first purifying unit are disposed, and even a first regulating valve regulating the air volume may be disposed in the first main pressure regulating system, so that after the first main pressure regulating system starts to work, air can be sucked from the outside, the air sucked from the outside is purified, the first main internal space 12 is allowed to be operated at a positive pressure higher than the atmospheric pressure of the external space by allowing clean air to enter the first main internal space 12 in a top-to-bottom direction. First main pressure regulating system links up the income wind gap of first main inner space 12 is uncovered form, and open area is less than a little the wind that first operation platform 101 upper surface area can let like this first operation platform 101 top has the parallel air current from the top down direction of as big as possible scope and blows, not only lets the air flow field even but also can drive effectively showy particle in the first main inner space 12 reduces and pollutes and then avoid influencing the negative consequence of testing result to inside reagent or material instrument, also can the brute force stop any driftage thing leaks out in the first pass-through window 4. Since the working condition in the first main internal space 12 is positive pressure, the first window and door 13 may not be set or may be in a normally open state. However, in order to prevent the entry of external dust when the window is not in use, it is preferable to provide the first window and door 13.
This embodiment will first main control unit 11's first fan and first purification unit arrange on first support body 10 and be located above first main inner space 12, first purification unit in the first main pressure regulating system can be primary filter or high efficiency filter, and even can include the filter that can filter and kill the microorganism, and the actual demand that specific setting mode used to satisfy relevant technical standard and customer is the standard. The inlet 111 of the first main control unit 11 communicates with an external space to suck air, the outlet pipe communicates with the first main internal space 12 through the top wall portion of the first main internal space 12 to blow air in a top-down direction, and the blower and the first cleaning unit are disposed on an air flow path between the inlet 111 and the first main internal space 12. In another equivalent external blowing implementation structure, if the reagent preparation module 1 is disposed in an indoor space, a centralized purified air blowing pipe may be installed in the indoor space, and the purified air blowing pipe is directly communicated with the first main internal space 12 so as to blow the purified air from the outside to the first main internal space 12; at this time, the first fan and the first purifying unit in the first main control unit 11 are disposed at other suitable positions far away from the first frame body 10, and purified air is directly sent into the first main inner space 12 through a pipeline connecting the first fan and the first purifying unit, so long as the working efficiency of the first main control unit 11 is not affected.
Since the operation mode in which the first main control unit 11 supplies air to the first main internal space 12 is adopted, the first main internal space 12 can be kept operating at a positive pressure for this purpose. The internal pressure of the first main internal space 12 is maintained at about +15pa in this embodiment. Therefore, the first window 13 can be opened at any time during the experiment to allow the first main internal space 12 to receive the reagent, the auxiliary material and the like fed from the outside, and even if foreign matters such as dust, bacteria and the like adhere to the reagent and the auxiliary material fed from the outside, the foreign matters can be washed away by the flowing air in the first main internal space 12 and carried out of the first main internal space 12. Since these dust and their bacteria are generally common substances in the air, the escape from the first main inner space 12 does not cause any harm to the experimenter. According to the invention, the reagent preparation module 1 is arranged and the interior of the reagent preparation module is operated in a positive pressure mode in a clean environment, so that the detection materials such as detection reagents are prevented from being polluted to influence the subsequent detection result, and a first guarantee and safety are provided for continuous experiments.
The first main control unit 11 further comprises a first pressure sensor and a first display 14 arranged on the reagent preparation module 1 and adapted to the first main internal space 12 for sensing and visually displaying the working pressure in the first main internal space 12. The first pressure sensor may be optionally disposed in the first main pressure regulating system, or may be disposed on a wall of the first main internal space 12. The first main control unit 11 further includes a first controller disposed on the reagent preparation module 1, the first controller is in signal connection with the first pressure sensor, the first display, the first fan, and even in signal connection with the first control valve, the germicidal lamp, the illuminating lamp, and the operation switch, and controls the first fan, the first control valve, the germicidal lamp, and the illuminating lamp according to the pressure signal fed back by the first pressure sensor, so as to stabilize the air pressure in the first main internal space 12 relative to the external space. The first window and door 13 may be manual or electric, or even may be an auto-induction opening and closing door for automatically opening the first window and door 13 in response to a door opening request. The first door 13 is a normal door, and automatically maintains a closed state.
As shown in fig. 2 and 3, the sample processing module 2, also referred to as a biosafety cabinet, is configured as a space for operations such as mixing and dispensing a reagent and a biological sample, and includes a second frame body 20, a second operation platform 201 and a second main internal space 22 disposed above the second operation platform 201 are configured in the second frame body 20, a second operation window communicating with the second main internal space 22 and a second window door 23 having a light transmission function are disposed at a front side of the second frame body 20, the second window door 23 can move up and down to open or close the second operation window, the second window door 23 can transmit light to allow an operator to directly observe and operate the second operation window, but the operator cannot open the second window door 23 at will during an experiment. Secondly, a sealing member is arranged between the second window and door 23 and the second frame 20, so that the possibility of the harmful samples inside escaping is reduced as much as possible during the experiment. The height of the second operation platform 201 of the second main internal space 22 is suitable for the operation of the experimenter. A germicidal lamp and an illumination lamp (not visible in the second frame body 20 shown in fig. 2) are also mounted on the upper wall or the side wall of the second main internal space 22. And casters are arranged below the second frame body 20 to facilitate movement. The sample processing module 2 is an independent frame type device, and can be independently manufactured, packaged, transported to the site and then assembled with other module devices.
The second main control unit 21 is used for managing the air pressure working condition in the second main internal space 22, and includes a second main pressure regulating system, where the second main pressure regulating system refers to the whole channel path that the air is sucked from the second main internal space 22 and then discharged to the external space, a second fan and a second purifying unit (not visible in the second frame body 20 shown in fig. 2) and a connecting pipeline communicated with the front and rear ends of the second fan and the second purifying unit are arranged in the path (i.e. the second main pressure regulating system), and even a second regulating valve for regulating the air volume may be arranged in the second main pressure regulating system, in this embodiment, the second fan and the second purifying unit in the second main control unit 21 are arranged on the second frame body 20 and located above the second main internal space 22, and the second main pressure regulating system is communicated with the second main internal space 22, so that the air sucked from the second main internal space 22 can be purged to the external space in a drag-and-drop manner, and the second main internal space 22 can be operated with a negative pressure lower than the atmospheric pressure of the external space, and generally, the working pressure in the second main internal space 22 is set to about-15 pa, so that the working pressure difference between the first main internal space 12 and the second main internal space 22 is about 30 pa. An outlet 211 of the second main pressure regulating system of the second main control unit 21 communicates with an external space, an inlet pipe communicates with the second main internal space 22 through a vertical side or a top wall of the second main internal space 22, and the second fan and the second purification unit are disposed on an air flow path between the outlet 211 and the second main internal space 22. In another equivalent embodiment, if the sample processing module 2 is disposed in an indoor space, a centralized exhaust duct may be further installed in the indoor space, and one end of the exhaust duct is connected to the second main internal space 22, which is equivalent to an extension line of the air intake duct section of the second main control unit 21, so that the second blower and the second purification unit in the second main control unit 21 may be disposed at other suitable positions away from the second rack 20, such as a centralized waste gas recycling processing center, and the air in the second main internal space 22 is directly sucked through the exhaust duct, as long as the working performance of the second main control unit 21 is not affected. In the following embodiments, the arrangement of various other mechanisms, such as the third main control unit 31, may be mentioned separately, and the same scheme may be adopted. Due to the fact that the first main internal space 12 is operated under positive pressure and the second main internal space 22 is operated under negative pressure, the reagent or the sample in the second main internal space 22 can be prevented from escaping into the first main internal space 12 or the first transfer window 4, and biological safety is ensured. The second purification unit of the second main control unit 21 comprises a filter capable of filtering or sterilizing microorganisms, and is arranged in a manner to meet the relevant technical standards and the actual requirements of customers.
Since the second main inner space 22 is used for the works such as the mixing and dispensing of the reagent and the biological sample, there is inevitably a problem that the reagent or the sample (inactivated or non-inactivated organism) may escape during the work, and therefore, the reagent, the auxiliary material or the sample, etc. fed from the outside cannot be received by opening the second window 23 during the experiment. The second main inner space 22 can keep operating under a negative pressure condition, so that the problem that a reagent or a biological sample escapes to an external space can be avoided, and the biological safety of an experiment is guaranteed. After the experiment, the second window 23 can be opened by cleaning and sterilizing the peripheral wall of the second main internal space 22 and various tools therein with the disinfectant transferred from the first main internal space 12. For this reason, the second window 23 preferably has an automatic locking function, and cannot be opened arbitrarily without an active operation.
A pair of operation ports 25 for hands to pass through are arranged on the second window and door 23, and rubber gloves 26 for hands to wear are connected to the operation ports 25 in a sealing mode. In this case, the experiment is performed by manually inserting the second window/door 23 into the second main internal space 22 through the rubber glove 26. Of course, an equivalent embodiment is also possible, in which a handling robot (not shown) is arranged in the second main inner space 22, by means of which the sampling, conditioning, blending and feeding to the next process etc. are known to be well established in the prior art.
The second main control unit 21 further comprises a second pressure sensor and a second display 24, which are arranged on the sample processing module 2 and adapted to the second main inner space 22, for sensing and visually displaying the working pressure in the second main inner space 22. The second pressure sensor may be selectively disposed in the second main pressure regulating system of the second main control unit 21, or may be disposed on a wall of the second main internal space 22. The second main control unit 21 further includes a second controller disposed on the sample processing module 2, the second controller is connected to the second pressure sensor, the second display 24, the second control valve and the second blower via signals, and even can be connected to the germicidal lamp, the illumination lamp and the operation switch via signals, so as to control the operation of the second blower, the second control valve, the germicidal lamp and the illumination lamp via the pressure signals fed back by the second pressure sensor, thereby stabilizing the air pressure in the second main internal space 22 relative to the external space.
As shown in fig. 2 and fig. 3, the amplification and detection module 3, also called a biosafety cabinet, is used for amplification and detection of a biological sample. The experiment device comprises a third frame body 30, a third operation platform 301 and a third main inner space 32 arranged above the third operation platform 301 are built in the third frame body 30, a third operation window communicated with the third main inner space 32 and a third window 33 with a light transmission function are arranged at the front side of the third frame body 30, the third window 33 can move up and down to open or close the third operation window, the third window 33 can be manual or electric, and an experimenter can open or close the third window 33 according to work requirements during experiments. The height of the third operation platform 301 is suitable for the operation of the experimenter. A germicidal lamp and an illumination lamp (not visible in the third frame 30 shown in fig. 2) are also mounted on the upper wall or the side walls of the third main internal space 32. And casters are arranged below the third frame body 30, so that the third frame body is convenient to move. The amplification detection module 3 is an independent frame type device, and can be independently manufactured, packaged and transported to the site and then assembled with other module devices.
The first frame 10, the second frame 20 and the third frame 30 may be separated from each other and then connected together, or may be prefabricated into an integral structure. If it is produced as a single-piece construction, it is sufficient if the first main interior space 12, the second main interior space 22 and the third main interior space 32 are each reserved.
The third main control unit 31 is further included for managing the air pressure condition in the third main internal space 32, and includes a third main pressure regulating system, where the third main pressure regulating system refers to the whole path of the channel that the air passes through after being sucked from the third main internal space 32 and then discharged to the external space, a third fan and a third purifying unit (not visible in the third frame 30 shown in fig. 2) and a connecting pipeline communicated with the front and rear ends of the third fan and the third purifying unit are disposed in the path (i.e., the third main pressure regulating system), and even a third regulating valve for regulating the air volume may be disposed in the third main pressure regulating system, in this embodiment, the third fan and the third purifying unit in the third main pressure regulating system are disposed on the third frame 30 and above the third main internal space 32, and the third main pressure regulating system is communicated with the third main internal space 32, so that the air sucked from the third main internal space 32 can be purified to the external space in a one-by-one mode, and the third main internal space 32 can also be operated at a negative pressure which is not much different from the internal air pressure of the second main internal space 22; in a further improved embodiment, the working pressure in the third main internal space 32 may be relatively lower than the working pressure in the second main internal space 22, for example, the working pressure in the third main internal space 32 may be set to about-20 pa to-30 pa, which may further reduce the probability of the floating objects escaping from the third main internal space 32. An outlet 311 of the third main pressure regulating system communicates with an external space, and an inlet pipe communicates with the third main internal space 32 through a vertical side portion or a top wall portion of the third main internal space 32. The third fan and the third cleaning unit of the third main control unit 31 are disposed on the air flow path between the outlet 311 and the third main internal space 32. The third purifying unit in the third main control unit 31 contains a filter capable of filtering or eliminating microbes, and is specifically arranged in a manner of meeting the relevant technical standards and the actual requirements of customers. In another equivalent external air draft embodiment structure, a centralized air draft pipe may be further installed, one end of the air draft pipe is communicated to the third main internal space 32, which is equivalent to an extension line of an air intake pipe section of the third main control unit 31, so that the third fan and the third purification unit in the third main control unit 31 may be disposed at other suitable positions far away from the third frame body 30, such as a centralized waste gas recycling processing center, and the air in the third main internal space 32 is directly sucked through the air draft pipe, as long as the working performance of the third main control unit 31 is not affected.
There are three equivalent modes of implementation for performing the detection and management of the third window 33 in the third main internal space 32. The first mode is a simple mode, considering that the biological sample is inactivated by adding reagent into the second main internal space 22, the possibility of the biological activity of the biological sample delivered to the third main internal space 32 is very low, and the air pressure condition of the third main internal space 32 is also very low negative pressure, so that the manual operation test can be performed by opening the third window 33. In a conventional experiment, the door leaf is generally opened at a position about half the height, and a human hand can stretch into the door leaf for operation. The second is a high-safety-level operation mode, in order to prevent that there may be organisms without inactivation from escaping, the third window 33 can be transparent to light and allow an operator to directly observe and operate the third window, a sealing member is arranged between the third window 33 and the third frame body 30, the third window 33 is not opened when detecting, the third main inner space 32 keeps negative pressure working condition operation, and automatic robot detection is adopted, so that the problem that a reagent or a sample escapes to the outer space can be better avoided, and the safety of a guarantee experiment is greatly improved. Of course, after the experiment is finished, the third window 33 can be opened by cleaning and sterilizing the peripheral wall of the third main internal space 32 and various tools therein with the disinfectant delivered from the first main internal space 12 and the second main internal space 22, and at this time, the third window 33 preferably has an automatic locking function and cannot be opened freely by an inactive operation. And the third mode is also a high-safety-level operation mode, on the basis of the second scheme, the robot is omitted, a pair of operation openings for allowing the hands to pass through are formed in the third window and door 33, rubber gloves (not shown in the figure) for allowing the hands to pass through are hermetically connected to the operation openings, and the third window and door 33 is closed to perform manual observation and operation experiments.
The third main control unit 31 further includes a third pressure sensor and a third display 34 disposed in the amplification detection module 3 and adapted to the third main internal space 32, for sensing and visually displaying the working pressure in the third main internal space 32. The third pressure sensor may be selectively disposed in the third main pressure regulating system of the third main control unit 31, or may be disposed on a wall of the third main internal space 32. The third main control unit 31 further includes a third controller disposed on the amplification detection module 3, the third controller is in signal connection with the third pressure sensor, the third display 34, the third control valve and the third blower, and even can be in signal connection with a germicidal lamp, an illumination lamp and an operation switch, so as to control the operation of the third blower and the third control valve by using the pressure signal fed back by the third pressure sensor, thereby stabilizing the air pressure in the third main inner space 32 relative to the external space.
As shown in fig. 2 and 3, the first transfer window 4 includes an outer casing 400, two first door leaves 40 mounted on the outer casing 400 and locked to each other, and a first in-box space enclosed by the outer casing 400 and the first door leaves 40 and used for transferring the test materials such as reagents, instruments, etc. in the first main internal space 12 to the second main internal space 22 (but not transferring the biological samples).
The combined type experiment platform comprises a first primary control unit, wherein the first primary control unit is arranged at a proper position on the combined type experiment platform 100 and used for managing the air pressure working condition in the first transmission window 4, the first primary control unit comprises a first primary pressure regulating system, the first primary pressure regulating system refers to a whole channel path which is passed by air sucked from the first transmission window 4 and then discharged to the external space, a first primary fan and purifying unit 41 and connecting pipelines communicated with the front end and the rear end of the first primary fan and purifying unit 41 are arranged in the path (namely the first primary pressure regulating system), even a first valve for regulating and controlling the air quantity can be arranged in the first primary pressure regulating system, an input pipe 411 of the first primary pressure regulating system is connected with an air output pipe 401 of the first transmission window 4, so that the air in the first transmission window 4 can be sucked to the external space in a one-dragging mode, the first sub-fan of the first sub-fan and purification unit 41 operates to maintain the inside of the first transfer window 4 not only in a negative pressure operation but also in a negative pressure operation lower than the internal pressure of the second main internal space 22. The purification units of the first primary air blower and purification unit 41, which contain filters capable of filtering or sterilizing microorganisms, are arranged in a manner to meet the relevant technical standards and the actual needs of the customers. Therefore, when experimental materials are transferred, no matter any door of the first transfer window 4 is opened, various drifts in the first transfer window 4 cannot enter the first main inner space 12 or the second main inner space 22, and a microbial drift propagation path is blocked, so that the continuous transfer of the materials can be realized, and a second guarantee and safety are provided for continuous experiments. In another equivalent external draft embodiment, the first blower and the purification unit of the first pressure regulating system may be disposed at another suitable location away from the integrated laboratory platform 100, such as a centralized waste gas recycling center, and directly suck the air in the first in-box space through a connecting pipe, as long as the working performance of the first transmission window 4 is not affected.
The two first door leaves 40 locked with each other mean that after any one of the first door leaves 40 is opened, the other first door leaf 40 cannot be opened, and at most one door leaf can be opened. After the first door leaf 40 on the left side is opened, the first in-box space in the first transfer window 4 can be communicated with the first main internal space 12 to lock the first door leaf 40 on the right side and the corresponding second main internal space 22, and vice versa, the first in-box space in the first transfer window 4 can be selectively communicated with the first main internal space 12 and the second main internal space 22 through the two mutually locked first door leaves 40, so that a microbial drift propagation path is blocked. The two second leaves 50 locked to each other and the two third leaves 60 locked to each other, which will be mentioned later, have the same meaning and structure.
Because the negative pressure value in the first transfer window 4 is lower than the ambient air pressure, the two sides of the first door leaf 40 have a larger pressure difference, and the opening of the first door leaf 40 has a certain difficulty, therefore, an electric door opening device is arranged on the first transfer window 4, and the electric door opening device is used for responding to a door opening instruction of a user to open a corresponding first door leaf 40 and lock the other door.
The first sub-control unit further comprises a first sub-pressure sensor and a first sub-display (the first sub-display is incorporated in the first display 14) which are arranged at appropriate positions on the combined experimental platform 100 and are adapted to the first transmission window 4, and the first sub-pressure sensor and the first sub-display are used for sensing and visually displaying the working pressure in the first transmission window 4. The operating pressure in the first transmission window 4 is generally set to about-20 pa to-25 pa. The first secondary control unit further comprises a first secondary controller, and the first secondary controller is respectively connected with the first secondary pressure sensor of the first transmission window 4, the first secondary display, the first secondary fan, the second controller, the first secondary valve and other signals, so that the pressure signal in the first transmission window 4 fed back by the pressure sensor is utilized, and even the pressure signal in the second main inner space 22 provided by the second controller is included, so as to control the work of the first secondary fan and the first secondary valve.
The right side of first support body 10 has been seted up the adaptation in the entrance to a cave 15 of first delivery window 4, the left side of second support body 20 has been seted up the adaptation in the entrance to a cave 27 of first delivery window 4, first delivery window 4 installation is fixed and sealed intercommunication is in between first support body 10 and the second support body 20, in turn, first support body 10, second support body 20 also can be with the help of realize connecting such as first delivery window 4 and other decorative boards.
As shown in fig. 3, the second transfer window 5 includes an outer casing 500, two second door leaves 50 installed on the outer casing 500 and locked with each other, and a second main internal space enclosed by the outer casing 500 and the second door leaves 50, and is configured to transfer a biological sample in an external space to the second main internal space 22, that is, to allow the biological sample and the test material to pass through different access passages.
The combined experimental platform 100 comprises a second secondary control unit, a second secondary pressure regulating system, a second secondary valve and a second secondary pressure regulating system, wherein the second secondary control unit is used for managing the air pressure working condition in the second transmission window 5, the second secondary control unit is arranged on a proper position on the combined experimental platform 100 and comprises the second secondary pressure regulating system, the second secondary pressure regulating system refers to the whole channel path which is passed by air sucked from the second transmission window 5 and then discharged to the external space, a second secondary fan and purifying unit 51 and a connecting pipeline communicated with the front end and the rear end of the second secondary fan and purifying unit 51 are arranged in the path (namely the second secondary pressure regulating system), even the second secondary valve for regulating and controlling the air volume can be arranged in the second secondary pressure regulating system, an input pipe 511 of the second secondary pressure regulating system is connected with an air output pipe 501 of the second transmission window 5, so that the air in the second transmission window 5 can be sucked to the external space in a one-to-in-one mode, the second secondary air blower in the second secondary air blower and purification unit 51 operates to keep the inside of the second transfer window 5 operating not only under a negative pressure condition but also under a negative pressure condition lower than the internal pressure of the second main internal space 22. The purification units of the second sub-air blower and purification unit 51, which contain filters capable of filtering or sterilizing microbes, are arranged in a manner to meet the relevant technical standards and the actual needs of customers. Therefore, when the biological samples are transferred, no matter any door of the second transfer window 5 is opened, various drifts in the second transfer window 5 cannot enter the second main inner space 22 or the outer space, the drift propagation path of the microorganisms is blocked, and then the biological samples can be continuously transferred, so that a third guarantee and safety are provided for continuous experiments. In another equivalent external air draft embodiment, the second secondary air blower and the purification unit in the second secondary pressure regulating system of the second secondary control unit can also be disposed at other suitable locations away from the combined experimental platform 100, such as a centralized waste gas recycling and processing center, and directly suck the air in the second in-box space through the connecting pipe, as long as the working performance of the second transfer window 5 is not affected.
Because the negative pressure value in the second transfer window 5 is lower than the ambient air pressure, the two sides of the second door leaf 50 have a large pressure difference, and it is difficult to open the second door leaf 50, for this reason, an electric door opening device may be further disposed on the second transfer window 5, and the electric door opening device is configured to open a corresponding one of the second door leaves 50 in response to a door opening instruction of a user to lock another door.
The second sub-control unit further comprises a second sub-pressure sensor and a second sub-display (the second sub-display is incorporated in the second display 24) which are arranged at suitable positions of the combined experimental platform 100 and are adapted to the second transmission window 5, and are used for sensing and visually displaying the working pressure in the second transmission window 5. The operating pressure in the second transmission window 5 is generally set to about-20 pa to-25 pa. The second secondary control unit further comprises a second secondary controller, and the second secondary controller is respectively connected with the second secondary pressure sensor of the second transmission window 5 and signals of a second secondary display, a second secondary blower, a second controller, a second secondary valve and the like, so that the pressure signals in the second transmission window 5 fed back by the second secondary pressure sensor are utilized, and even the pressure signals in the second main inner space 22 provided by the second controller are included, so as to control the work of the second secondary blower and the second secondary valve.
The second transmission window 5 is fixedly installed and is in sealed communication with the second frame body 20, and in another embodiment, may also be installed between the first frame body 100 and the second frame body 20. The first transfer window 4 and the second transfer window 5 are vertically stacked or arranged in a front-to-back manner, an inner door leaf of the second transfer window 5 is opened to the second main inner space 22, and an outer door leaf is directly communicated with the outside. The first and second transmission windows 4, 5 thus form two independent access channels to the second main interior space 22. When the second door 50 inside the second transfer window 5 is opened, the second in-box space communicates with the second main space 22, but the second door 50 outside cannot be opened at this time; when the second door leaf 50 outside the second transfer window 5 is opened, the second in-box space is communicated with the external space, but the second door leaf 50 inside cannot be opened at this time to enable the second in-box space to be communicated with the second main internal space 22, so that the second in-box space in the second transfer window 5 can be selectively communicated with the external space and the second main internal space 22 through two mutually locked second door leaves 50, and a microbial drift propagation path is blocked.
As shown in fig. 2 and 3, the third transfer window 6 includes an outer casing 600, two third leaves 60 mounted on the outer casing 600 and locked to each other, and a third in-box space enclosed by the outer casing 600 and the third leaves 60, and is used for transferring the test materials, such as prepared samples, reagents, instruments, etc., in the second main internal space 22 into the third main internal space 32.
The combined experimental platform 100 comprises a third secondary control unit, a third pressure regulating system, a third valve, a third air blower and purifying unit 61, and connecting pipes, wherein the connecting pipes are arranged at the front end and the rear end of the third air blower and purifying unit 61, the third valve is arranged in the third pressure regulating system for regulating and controlling air volume, the input pipe 611 of the third pressure regulating system is connected with the air output pipe 601 of the third transmission window 6, so that the air in the third transmission window 6 can be sucked to the external space in a one-to-one mode, the third blower in the third blower and purification unit 61 operates to keep the interior of the third transfer window 6 not only operating under a negative pressure condition but also operating under a lower pressure condition than the air pressure conditions in the second main internal space 22 and the third main internal space 32. The third blower and the purification unit 61 comprises a filter capable of filtering or eliminating microbes, and the third blower and the purification unit are arranged in a manner to meet the relevant technical standards and the actual needs of customers. Therefore, when the prepared detection sample and other materials are transferred, no matter any door of the third transfer window 6 is opened, various drifts in the third transfer window 6 cannot enter the second main inner space 22 or the third main inner space 32, so that the microbial drift propagation path is blocked, the materials can be continuously transferred, and a fourth guarantee and safety are provided for continuous experiments. In another equivalent external air draft embodiment, the third blower and the purification unit in the third pressure regulating system of the third sub-control unit can also be disposed at another suitable location away from the combined experimental platform 100, such as a centralized waste gas recycling center, and directly suck the air in the third in-box space through a connecting pipe, as long as the working performance of the third transfer window 6 is not affected.
Because the negative pressure value in the third pass-through window 6 is lower than the ambient air pressure, the two sides of the third door leaf 60 have a large pressure difference, and it is difficult to open the third door leaf 60 to a certain extent, for this reason, an electric door opening device may be further disposed on the third pass-through window 6, and the electric door opening device is configured to open a corresponding one of the third door leaves 60 in response to a door opening instruction of a user to lock another door.
The third sub-control unit further comprises a third sub-pressure sensor and a third sub-display (the third sub-display is incorporated in the third display 34) which are arranged at suitable positions on the combined experimental platform 100 and are adapted to the third transmission window 6, and are used for sensing and visually displaying the working pressure in the third transmission window 6. The third secondary control unit further comprises a third secondary controller, and the third secondary controller is respectively connected with the third pressure sensor of the third transmission window 6, a third display, a third blower, a third controller, a third valve and other signals, so that the pressure signal in the third transmission window 6 fed back by the third pressure sensor is utilized, and even the pressure signal in the third main inner space 32 provided by the third controller is included, so as to control the work of the third blower and the third valve.
The right side of the second frame body 20 is provided with an opening 28 adapted to the third transfer window 6, the left side of the third frame body 30 is provided with an opening 35 adapted to the third transfer window 6, the third transfer window 6 is butted with the opening 28 and the opening 35 and is fixedly installed and hermetically communicated between the third frame body 30 and the second frame body 20, and conversely, the second frame body 20 and the third frame body 30 can also be connected by means of the first transfer window 6 and other decorative plates. When the third door 60 on the left side of the third transfer window 6 is opened, the third in-box space is communicated with the second main internal space 22, but the third door 60 on the right side cannot be opened at this time; when the third door leaf 60 on the right side of the third transfer window 6 is opened, the third in-box space is communicated with the third space 32, but the third door leaf 60 on the left side cannot be opened, so that the third in-box space in the third transfer window 6 can be selectively communicated with the third main space 32 and the second main space 22 through the two mutually locked third door leaves 60, and a microbial drift propagation path is blocked.
A central controller can be arranged to manage the first controller, the second controller, the third controller, the first secondary controller, the second secondary controller and the third secondary controller or manage the tasks managed by the first controller, the second controller, the third controller, the first secondary controller, the second secondary controller and the third secondary controller.
The second main control unit 21, the third main control unit 31, the first secondary control unit, the second secondary control unit and the third secondary control unit in the above embodiments are all working units that form a negative pressure working condition by using suction gas, and they have common characteristics of a negative pressure working condition and biological purification. For this reason, these units may be provided independently, or two or more units may be combined and shared in order to save the manufacturing cost. Specifically, the method comprises the following steps:
the system can also be characterized in that a delivery window centralized air extraction and purification unit, such as a centralized waste gas recovery and treatment center, is used for replacing a secondary fan and a purification unit in a secondary pressure regulating system of the first secondary control unit and the second secondary control unit, so that the delivery window centralized air extraction and purification unit is respectively communicated with the first in-box space and the second in-box space through different air extraction pipe sections in a one-to-two mode; the air in the two air extraction pipe sections respectively communicated with the first in-box space and the second in-box space is preferably combined at the outlet of the air extraction and purification unit after passing through the purification unit respectively, so as to prevent the short circuit of air cross flow between the first in-box space and the second in-box space; since the pressure conditions inside the first and second tank internal spaces are lower than the pressure conditions inside the second main internal space 22, both of them belong to the same pressure class and purification treatment class, and this solution is also a possible equivalent solution for this purpose.
Based on the same principle, a delivery window centralized air extraction purification unit, such as a centralized waste gas recovery processing center, can be used to replace the secondary fan and the purification unit in the secondary pressure regulating system of the first secondary control unit and the third secondary control unit, or the secondary fan and the purification unit in the secondary pressure regulating system of the second secondary control unit and the third secondary control unit. Alternatively, as shown in the embodiment of fig. 4, a secondary blower and a purification unit in the secondary pressure regulating system of the first secondary control unit, the second secondary control unit and the third secondary control unit may be replaced by a centralized pumping purification unit 71 with a delivery window, such as a centralized waste gas recycling treatment center, a blower and a purifier are arranged in the centralized pumping purification unit 71 with the centralized pumping purification unit 71 communicating the first in-box space, the second in-box space and the third in-box space through three pumping pipe sections in a one-to-three mode.
In this one-to-two or one-to-three combined pumping mode scheme, in order to provide different working pressure levels in the first, second and third tank spaces, it is fully possible to adjust the pressure of the first, second and third sub-valves respectively provided in the pumping line sections (not shown in the figure). Or, an air supply system is arranged corresponding to each delivery window, wherein the air supply system refers to the whole channel path which is passed when external air is sucked and then enters the delivery window, a purification and regulation valve is arranged on the air supply system, and the purification and regulation valve and the secondary control unit are matched to regulate the internal working pressure of the delivery window. Specifically, as shown in fig. 4, the first air make-up system is matched with the first delivery window 4, the first air make-up system includes a first purifying unit 42 and a regulating valve 421, and a first output pipe section 43 communicating the first purifying unit 42 and the regulating valve 421, the first output pipe section 43 communicates the first purifying unit 42, the regulating valve 421 and an air inlet pipe (not shown in the figure) of the first delivery window 4, the first purifying unit 42 has a filter therein, and the regulating valve 421 belongs to a mechanical valve to perform pressure (flow) setting so as to not only adjust the output air pressure (flow) of the first air make-up system but also purify the output air to reach the experimental standard; the first air supply system is communicated with the first in-box space of the first delivery window 4, so that the first air supply system can be matched with the first secondary control unit to regulate the air pressure working condition in the first in-box space of the first delivery window 4 by using the principle of regulating and controlling the air supply quantity and the air discharge quantity by suction as a basic element. The air pressure rises sharply during the opening of the first transfer window 4, and drops sharply during the closing of the first transfer window, and only a small amount of air flows out, so that the air flow rate changes greatly and the pressure changes greatly depending on the use state. In order to alleviate these problems, an electromagnetic valve may be further disposed in the first air supplement system, where the electromagnetic valve is in signal connection with the first secondary controller, and cooperates with the first secondary pressure sensor to timely adjust the air pressure in the first tank space.
The device also comprises a second air supplementing system (comprising a second purifying unit 52, a regulating valve, an electromagnetic valve, an output pipe section and the like) corresponding to the second delivery window 5 and a third air supplementing system (comprising a third purifying unit 62, a regulating valve, an electromagnetic valve, an output pipe section and the like) corresponding to the third delivery window 6, and the second air supplementing system and the third air supplementing system have the same working principle and structure as the first air supplementing system. Of course, these air supply systems may be incorporated.
Secondly, based on the same principle, another embodiment may also be that, since the first secondary control unit, the second secondary control unit and the third secondary control unit are only different from the second main control unit 21 and the third main control unit 31 in terms of air pressure level, the biosafety level is the same, and only the third main control unit 31 pumps a larger amount of air during the experiment, and the air pumping amount required by other units is smaller, for this reason, a further improved embodiment may also be that the first secondary control unit, the second secondary control unit and the third secondary control unit are combined with the second main control unit 21 and the third main control unit 31 to share one centralized air pumping purification unit 71 to purify all the pumped air and then discharge the purified air to the external space, and then different negative pressures are distributed to different spaces by using a method including the above-mentioned pressure reduction structure.
After the machine is started, the first main inner space 12 is blown by clean air from top to bottom, the internal air pressure is adjusted to be about +15pa, the air pressure in the second main inner space 22 is adjusted to be about-15 pa in a suction mode, and the air pressure in the third main inner space 32 is adjusted to be about-15 pa in a suction mode in a first working state or about-20 pa to-30 pa in a second working state; the air pressures in the first and second in-tank spaces are controlled to be about-20 pa to-25 pa, respectively, and the air pressure in the third in-tank space of the third transfer window 6 is controlled to be lower than the air pressures in the second and third main spaces 22 and 32, for example, to be about-35 pa to-40 pa; at this time, the first window door 13 may be opened continuously to deliver materials such as reagents into the first main internal space 12, or the first door leaf 40 of the first transfer window 4 may be opened at any time to deliver materials such as reagents into the second main internal space 22, and due to the air pressure difference, floating impurities in the first transfer window 4 may not be diffused into the first main internal space 12 and the second main internal space 22, but may be directly sucked out by the first primary pressure regulating system and purified, so that floating impurities in the second main internal space 22 may not drift to the first main internal space 12 across the first transfer window 4, thereby forming a first basis of a continuous test; the second door leaf 50 of the second transfer window 5 can be opened at any time to deliver the biological sample to the second main internal space 22, and due to the air pressure difference, the floating impurities in the second transfer window 5 are not diffused to the internal or external space of the second main internal space 22 but directly sucked out by the second pressure regulating system and purified, so as to form the second basis of the continuous test. After the test sample is prepared and completed in the second main internal space 22, the third door 60 of the third transfer window 6 may be opened at any time to transfer the test sample to the third main internal space 32 to complete the final test, and then the test sample may be taken out from the third main internal space 32; since the air pressure in the third delivery window 6 is lower than the air pressure in the third main internal space 32, and the air pressure in the third main internal space 32 is much lower than the external air pressure, for this reason, the escaped objects in the third main internal space 32 will not drift to the second main internal space 22 across the third delivery window 6, and will not drift to the external space, but will be sucked out by the third pressure regulating system communicated with the third delivery window 6 and purified, so as to avoid cross infection, and form the third basis of continuous test. The purpose of this embodiment is to establish a safe, reliable and continuous platform for biological detection experiments, and for biological samples, various biochemical detection instruments or devices should be prepared or installed in each module, which are contents that the detection personnel self-prepares according to the characteristics of the experimental object, and do not belong to the object that this embodiment should include or prepare. According to the scheme, the working condition purposes of each module are summarized as follows:
according to the above structure and method, when the device is operated, not only the internal pressure gradient between the first transfer window 4 and the first main internal space 12, between the second main internal space 22, between the second transfer window 5 and the external space, between the second main internal space 22, between the third transfer window 6 and the third main internal space 32, and between the second main internal space 22, but also two different input channels are established, and the finally detected third main internal space 32 still maintains the negative pressure working condition without causing outward leakage, etc., and the structure and method independently play respective roles and also cooperate with each other, so that the device is less in pollution and safer compared with the prior art.
Claims (11)
1. The combined experimental platform capable of continuously running is characterized by comprising a reagent preparation module, a sample processing module and an amplification detection module which are sequentially arranged; wherein,
the reagent preparation module is used for constructing a channel for the reagent for detection and auxiliary materials to enter from an external space, and comprises a first operation platform, a first main inner space arranged above the first operation platform and a first operation window communicated with the first main inner space, wherein the first main inner space is arranged to receive clean air blown from the top of the first main inner space and can keep positive pressure operation;
the sample processing module is used for constructing a space for uniformly mixing and subpackaging a reagent and a biological sample, and comprises a second operation platform, a second main inner space arranged on the second operation platform and a second operation window communicated with the second main inner space, wherein a second window door with a light transmission function is arranged at the second operation window, and the second main inner space is arranged in a manner that air can be sucked to keep running under a negative pressure working condition;
the amplification detection module is used for constructing a space for detecting biological detection samples, and comprises a third operation platform, a third main inner space arranged above the third operation platform and a third operation window communicated with the third main inner space, wherein a third window door with a light transmission function is arranged at the third operation window, and the third main inner space is arranged in a manner that air can be sucked to keep running under a negative pressure working condition;
the first transmission window comprises two first door leaves which are locked with each other and is used for enabling a first in-box space in the first transmission window to be selectively communicated with the first main inner space and the second main inner space through the two first door leaves which are locked with each other; the first transfer window is internally arranged to enable air to be sucked and is kept to operate under a negative pressure working condition relatively lower than the internal pressure of the second main internal space;
the second transfer window comprises two second door leaves which are mutually locked, and is used for realizing selective communication between a second in-box space in the second transfer window and an external space as well as between a second main internal space through the two second door leaves which are mutually locked; the second transfer window is arranged to enable air to be sucked and is kept to operate under a negative pressure working condition relatively lower than the internal pressure of the second main internal space;
the third transfer window comprises two third door leaves which are mutually locked, and is used for realizing selective communication between a third box inner space in the third transfer window and the second main inner space and the third main inner space through the two third door leaves which are mutually locked; the third transfer window is arranged to allow air to be sucked and is maintained to operate at a negative pressure relatively lower than the internal pressures of the second and third main internal spaces.
2. The continuously operable modular laboratory platform according to claim 1, wherein said third main internal space is arranged to be air-pumpable and to be maintained in operation at a negative pressure relatively lower than the internal pressure of said second main internal space.
3. The combined type experiment platform capable of continuously operating according to claim 1, wherein a pair of operation openings for hands to pass through are arranged on the second window and door, and rubber gloves worn by the hands are hermetically connected to the operation openings.
4. The combined type experiment platform capable of continuously operating according to claim 1, wherein a pair of operation openings for hands to pass through are arranged on the third window door, and rubber gloves worn by the hands are hermetically connected to the operation openings.
5. The combined type experiment platform capable of continuously operating according to claim 1, wherein the first transmission window, the second transmission window or/and the third transmission window are respectively provided with an electric door opener, and the electric door openers are used for responding to a door opening instruction of a user and opening a corresponding door leaf.
6. A continuously operable modular laboratory platform according to one of the claims 1 to 5,
the first main control unit is used for managing the air pressure working condition in the first main inner space; the first main control unit comprises a first main pressure regulating system, a first fan and a first purification unit are arranged in the first main pressure regulating system, an inlet of the first main pressure regulating system is communicated with an external space, and an outlet of the first main pressure regulating system is communicated with a first main internal space;
the second main control unit is used for managing the air pressure working condition in the second main inner space; the second main control unit comprises a second air system, a second fan and a second purification unit are arranged in the second air system, an outlet of the second air system is communicated with an external space, and an inlet of the second air system is communicated with the second main internal space;
the third main control unit is used for managing the air pressure working condition in the third main inner space; the third main control unit comprises a third air system, a third fan and a third purification unit are arranged in the third air system, an outlet of the third air system is communicated with an external space, and an inlet of the third air system is communicated with the third main internal space.
7. The continuously operable modular assay platform according to claim 6,
the first main control unit further comprises a first controller, a first pressure sensor and a first display, the first fan, the first pressure sensor and the first display are in signal connection with the first controller, the first pressure sensor is used for sensing air pressure in the first main inner space, the first controller is used for controlling the first fan to work by utilizing a pressure signal fed back by the first pressure sensor and controlling the first display to correspondingly and visually display pressure sensed by the first pressure sensor;
the second main control unit further comprises a second controller, a second pressure sensor and a second display, the second fan, the second pressure sensor and the second display are in signal connection with the second controller, the second pressure sensor is used for sensing air pressure in the second main inner space, the second controller is used for controlling the second fan to work by utilizing a pressure signal fed back by the second pressure sensor and controlling the second display to correspondingly and visually display pressure sensed by the second pressure sensor;
the third main control unit further comprises a third controller, a third pressure sensor and a third display, the third fan, the third pressure sensor and the third display are in signal connection with the third controller, the third pressure sensor is used for sensing the air pressure in the third main inner space, the third controller is used for utilizing the pressure signals fed back by the third pressure sensor to control the work of the third fan and control the third display correspondingly and visually displays the pressure sensed by the third pressure sensor.
8. A continuously operable modular laboratory platform according to one of the claims 1 to 5,
the first secondary control unit is used for managing the air pressure working condition in the first transmission window; the first secondary control unit comprises a first secondary pressure regulating system, a first primary fan and a purifying unit are arranged in the first secondary pressure regulating system, and an input pipe of the first secondary pressure regulating system is communicated with a first in-box space of the first transmission window so as to be capable of sucking air in the first transmission window to an external space;
the second secondary control unit is used for managing the air pressure working condition in the second transfer window; the second secondary control unit comprises a second secondary pressure regulating system, a second secondary fan and a purifying unit are arranged in the second secondary pressure regulating system, and an input pipe of the second secondary pressure regulating system is communicated with a second in-box space of the second transfer window so as to be capable of sucking air in the second transfer window to an external space;
the third secondary control unit is used for managing the air pressure working condition in the third transfer window; the third secondary control unit comprises a third secondary pressure regulating system, a third secondary fan and a purifying unit are arranged in the third secondary pressure regulating system, and an input pipe of the third secondary pressure regulating system is communicated with a third in-box space of the third transfer window so as to suck air in the third transfer window to an external space in a mode.
9. The combined type experiment platform capable of continuously operating according to claim 8, wherein the first sub-control unit further comprises a first sub-controller, a first sub-pressure sensor and a first sub-display, the first sub-fan, the first sub-pressure sensor and the first sub-display are in signal connection with the first sub-controller, the first sub-pressure sensor is used for sensing the air pressure in the first in-box space, the first sub-controller is used for controlling the operation of the first sub-fan by using a pressure signal fed back by the first sub-pressure sensor and controlling the first sub-display to correspondingly and visually display the pressure sensed by the first sub-pressure sensor;
the second secondary control unit further comprises a second secondary controller, a second secondary pressure sensor and a second secondary display, the second secondary air blower, the second secondary pressure sensor and the second secondary display are in signal connection with the second secondary controller, the second secondary pressure sensor is used for sensing the air pressure in the second box space, the second secondary controller is used for controlling the work of the second secondary air blower by using a pressure signal fed back by the second secondary pressure sensor and controlling the second secondary display to correspondingly and visually display the pressure sensed by the second secondary pressure sensor;
the third secondary control unit further comprises a third controller, a third pressure sensor and a third display, the third air blower, the third pressure sensor and the third display are in signal connection with the third controller, the third pressure sensor is used for sensing air pressure in the third space in the box, and the third controller is used for controlling the third air blower to work by utilizing a pressure signal fed back by the third pressure sensor and controlling the third display to correspondingly and visually display pressure sensed by the third pressure sensor.
10. The continuously operable modular laboratory platform according to one of claims 1 to 5, further comprising a transfer window centralized air-extracting purification unit, wherein said transfer window centralized air-extracting purification unit comprises a purifier and a blower, and one transfer window centralized air-extracting purification unit is used to communicate with said first transfer window, said second transfer window, and said third transfer window through different input pipe sections in a two-by-two mode or in a three-by-three mode.
11. The combined experimental platform capable of continuously operating as claimed in any one of claims 1 to 5, further comprising a gas supply system, wherein the gas supply system comprises a purification unit and a regulating valve, and one gas supply system is respectively communicated with the first delivery window, the second delivery window and the third delivery window through different output pipe sections in a one-to-three mode, a one-to-one and one-to-two mixed mode or a one-to-one and one-to-two mode.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113308338A (en) * | 2021-06-11 | 2021-08-27 | 广东天赐湾实验室装备制造有限公司 | Combined type experiment platform capable of continuously running and management method thereof |
| CN114715624A (en) * | 2022-03-31 | 2022-07-08 | 老肯医疗科技股份有限公司 | Automatic lifting delivery window suitable for hospital disinfection supply center |
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2021
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113308338A (en) * | 2021-06-11 | 2021-08-27 | 广东天赐湾实验室装备制造有限公司 | Combined type experiment platform capable of continuously running and management method thereof |
| CN114715624A (en) * | 2022-03-31 | 2022-07-08 | 老肯医疗科技股份有限公司 | Automatic lifting delivery window suitable for hospital disinfection supply center |
| CN114715624B (en) * | 2022-03-31 | 2023-12-22 | 老肯医疗科技股份有限公司 | Automatic lifting transfer window suitable for hospital disinfection supply center |
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Address after: 528100 Lubao Town Industrial Development Zone, Sanshui District, Foshan City, Guangdong Province (F3) Patentee after: GUANGDONG TMOON LABORATORY EQUIPMENT MANUFACTURING Co.,Ltd. Patentee after: Beijing kayudi Biotechnology Co., Ltd Address before: 528100 Lubao Town Industrial Development Zone, Sanshui District, Foshan City, Guangdong Province (F3) Patentee before: GUANGDONG TMOON LABORATORY EQUIPMENT MANUFACTURING Co.,Ltd. Patentee before: Kayudi Biotechnology (Beijing) Co., Ltd |
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