CN107960105B - 用于降解不溶性和可溶性草酸的高效草酸降解酶 - Google Patents

用于降解不溶性和可溶性草酸的高效草酸降解酶 Download PDF

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CN107960105B
CN107960105B CN201680030901.2A CN201680030901A CN107960105B CN 107960105 B CN107960105 B CN 107960105B CN 201680030901 A CN201680030901 A CN 201680030901A CN 107960105 B CN107960105 B CN 107960105B
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oxalate
enzyme
acid
enzymes
activity
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CN107960105A (zh
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艾如·B·考利
伊莱娜·考利
颜钦
李青山
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Wuhan Kangfude Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01002—Oxalate decarboxylase (4.1.1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01008—Oxalyl-CoA decarboxylase (4.1.1.8)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/03—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with oxygen as acceptor (1.2.3)
    • C12Y102/03004—Oxalate oxidase (1.2.3.4)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Physiology (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
CN201680030901.2A 2015-04-02 2016-04-04 用于降解不溶性和可溶性草酸的高效草酸降解酶 Active CN107960105B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562141976P 2015-04-02 2015-04-02
US62/141,976 2015-04-02
PCT/US2016/025937 WO2016161455A2 (en) 2015-04-02 2016-04-04 High efficiency oxalate-degrading enzymes for degradation of insoluble and soluble oxalate

Publications (2)

Publication Number Publication Date
CN107960105A CN107960105A (zh) 2018-04-24
CN107960105B true CN107960105B (zh) 2025-05-16

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Country Status (7)

Country Link
US (2) US11603524B2 (en:Method)
EP (1) EP3277099B9 (en:Method)
KR (1) KR20180044225A (en:Method)
CN (1) CN107960105B (en:Method)
AU (2) AU2016244121B2 (en:Method)
CA (1) CA2984763C (en:Method)
WO (1) WO2016161455A2 (en:Method)

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Publication number Priority date Publication date Assignee Title
CN107868776A (zh) * 2016-09-23 2018-04-03 武汉康复得生物科技股份有限公司 糖基化草酸脱羧酶及其制备和应用
CN108588060B (zh) * 2017-03-07 2020-12-01 武汉康复得生物科技股份有限公司 一种用丝状真菌宿主细胞表达的重组草酸脱羧酶
CN108977455B (zh) * 2018-08-01 2021-07-20 武汉康复得生物科技股份有限公司 用于生产草酸脱羧酶的重组质粒、大肠杆菌表达系统及方法和应用
CN108998462B (zh) * 2018-08-01 2021-06-18 武汉康复得生物科技股份有限公司 含锰离子重组蛋白的大肠杆菌表达系统及其应用方法
CN113447585B (zh) * 2021-06-28 2022-03-15 中国食品药品检定研究院 基于液相色谱评价体外辅助生殖用液质量的方法
WO2023091607A1 (en) * 2021-11-19 2023-05-25 The Better For You Company, Llc Oxalic acid or oxalate free inonotus obliquus extract and uses thereof
WO2023154879A2 (en) * 2022-02-11 2023-08-17 Codexis, Inc. Engineered oxalate decarboxylases

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AU656761B2 (en) 1991-02-25 1995-02-16 Syngenta Limited Newly characterised oxalate oxidase and uses therefor
UA34467C2 (uk) 1992-11-30 2001-03-15 Зенека Лімітед Виділений та очищений днк фрагмент, що кодує оксалат-декарбоксилазу
US6187571B1 (en) 1992-12-07 2001-02-13 Biogemma Use of a DNA sequence coding for a protein capable of degrading oxalic acid as selection gene
US5945273A (en) 1997-06-03 1999-08-31 Human Genome Sciences, Inc. Human oxalyl-coa decarboxylase
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AU2021200688A1 (en) 2021-03-04
US20180362955A1 (en) 2018-12-20
CA2984763C (en) 2023-08-08
AU2021200688B2 (en) 2023-04-20
EP3277099A4 (en) 2018-10-24
EP3277099B1 (en) 2023-11-08
EP3277099A2 (en) 2018-02-07
CA2984763A1 (en) 2016-10-06
US20220298497A1 (en) 2022-09-22
CN107960105A (zh) 2018-04-24
AU2016244121A1 (en) 2017-11-23
AU2016244121B2 (en) 2020-11-05
EP3277099B9 (en) 2024-05-29
WO2016161455A2 (en) 2016-10-06
KR20180044225A (ko) 2018-05-02
WO2016161455A3 (en) 2016-11-24
US11603524B2 (en) 2023-03-14

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