CA2984763C - High efficiency oxalate-degrading enzymes for degradation of insoluble and soluble oxalate - Google Patents

High efficiency oxalate-degrading enzymes for degradation of insoluble and soluble oxalate Download PDF

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Publication number
CA2984763C
CA2984763C CA2984763A CA2984763A CA2984763C CA 2984763 C CA2984763 C CA 2984763C CA 2984763 A CA2984763 A CA 2984763A CA 2984763 A CA2984763 A CA 2984763A CA 2984763 C CA2984763 C CA 2984763C
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Prior art keywords
oxalate
enzyme
composition
enzymes
hexamer
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CA2984763A
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English (en)
French (fr)
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CA2984763A1 (en
Inventor
Aaron B. Cowley
Helena COWLEY
Qin Yan
Qingshan Li
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Orenzymes LLC
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Oxidien Pharmaceuticals LLC
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Publication of CA2984763A1 publication Critical patent/CA2984763A1/en
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52Adding ingredients
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44Oxidoreductases (1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51Lyases (4)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y102/00Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/03Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with oxygen as acceptor (1.2.3)
    • C12Y102/03004Oxalate oxidase (1.2.3.4)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y401/00Carbon-carbon lyases (4.1)
    • C12Y401/01Carboxy-lyases (4.1.1)
    • C12Y401/01002Oxalate decarboxylase (4.1.1.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y401/00Carbon-carbon lyases (4.1)
    • C12Y401/01Carboxy-lyases (4.1.1)
    • C12Y401/01008Oxalyl-CoA decarboxylase (4.1.1.8)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Physiology (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
CA2984763A 2015-04-02 2016-04-04 High efficiency oxalate-degrading enzymes for degradation of insoluble and soluble oxalate Active CA2984763C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562141976P 2015-04-02 2015-04-02
US62/141,976 2015-04-02
PCT/US2016/025937 WO2016161455A2 (en) 2015-04-02 2016-04-04 High efficiency oxalate-degrading enzymes for degradation of insoluble and soluble oxalate

Publications (2)

Publication Number Publication Date
CA2984763A1 CA2984763A1 (en) 2016-10-06
CA2984763C true CA2984763C (en) 2023-08-08

Family

ID=57007703

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2984763A Active CA2984763C (en) 2015-04-02 2016-04-04 High efficiency oxalate-degrading enzymes for degradation of insoluble and soluble oxalate

Country Status (7)

Country Link
US (2) US11603524B2 (en:Method)
EP (1) EP3277099B9 (en:Method)
KR (1) KR20180044225A (en:Method)
CN (1) CN107960105B (en:Method)
AU (2) AU2016244121B2 (en:Method)
CA (1) CA2984763C (en:Method)
WO (1) WO2016161455A2 (en:Method)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107868776A (zh) * 2016-09-23 2018-04-03 武汉康复得生物科技股份有限公司 糖基化草酸脱羧酶及其制备和应用
CN108588060B (zh) * 2017-03-07 2020-12-01 武汉康复得生物科技股份有限公司 一种用丝状真菌宿主细胞表达的重组草酸脱羧酶
CN108977455B (zh) * 2018-08-01 2021-07-20 武汉康复得生物科技股份有限公司 用于生产草酸脱羧酶的重组质粒、大肠杆菌表达系统及方法和应用
CN108998462B (zh) * 2018-08-01 2021-06-18 武汉康复得生物科技股份有限公司 含锰离子重组蛋白的大肠杆菌表达系统及其应用方法
CN113447585B (zh) * 2021-06-28 2022-03-15 中国食品药品检定研究院 基于液相色谱评价体外辅助生殖用液质量的方法
WO2023091607A1 (en) * 2021-11-19 2023-05-25 The Better For You Company, Llc Oxalic acid or oxalate free inonotus obliquus extract and uses thereof
WO2023154879A2 (en) * 2022-02-11 2023-08-17 Codexis, Inc. Engineered oxalate decarboxylases

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4455371A (en) 1982-03-03 1984-06-19 The Ohio State University Research Foundation Oxalate oxidase composition for assay of oxalate
US5137722A (en) 1991-01-16 1992-08-11 Allegheny-Singer Research Institute Extract and pharmaceutical composition for treatment of calcium oxalate stone disease
AU656761B2 (en) 1991-02-25 1995-02-16 Syngenta Limited Newly characterised oxalate oxidase and uses therefor
UA34467C2 (uk) 1992-11-30 2001-03-15 Зенека Лімітед Виділений та очищений днк фрагмент, що кодує оксалат-декарбоксилазу
US6187571B1 (en) 1992-12-07 2001-02-13 Biogemma Use of a DNA sequence coding for a protein capable of degrading oxalic acid as selection gene
US5945273A (en) 1997-06-03 1999-08-31 Human Genome Sciences, Inc. Human oxalyl-coa decarboxylase
US5635616A (en) 1995-06-02 1997-06-03 Human Genome Sciences, Inc. Human oxalyl-CoA decarboxylase
US5604111A (en) 1994-06-20 1997-02-18 University Of Florida Research Foundation Method and kit for detection of oxalate
US6214980B1 (en) 1994-06-20 2001-04-10 University Of Florida Materials and methods for detection of Oxalobacte formigenes
US6090628A (en) 1994-06-20 2000-07-18 University Of Florida Materials and methods for detection of Oxalobactor formigenes
US5776701A (en) 1996-05-31 1998-07-07 University Of Florida Materials and methods for detecting oxalate
US6297425B1 (en) 1997-03-21 2001-10-02 Pioneer Hi-Bred International, Inc. Gene encoding oxalate decarboxylase from aspergillus phoenices
US8486389B2 (en) 1997-05-23 2013-07-16 Oxthera, Inc. Compositions and methods for treating or preventing oxalate-related disease
US6355242B1 (en) 1997-05-23 2002-03-12 Ixion Biotechnology, Inc. Materials and methods for treating or preventing oxalate-related disease
DE69841200D1 (de) 1997-05-23 2009-11-12 Oxthera Inc Oxalate-abbauende mikroorganismen oder oxalate-abbauende enzyme zur verhütung der oxalate-verwandten krankheiten
US5985938A (en) 1997-11-05 1999-11-16 Geltex Pharmaceuticals, Inc. Method for reducing oxalate
US6566407B2 (en) 1997-11-05 2003-05-20 Geltex Pharmaceuticals, Inc. Method for reducing oxalate
US6521645B2 (en) 2000-11-20 2003-02-18 The University Of Kansas Medical Center Methods for the treatment and prevention of urinary stone disease
US8309118B2 (en) 2001-09-28 2012-11-13 Mcneil-Ppc, Inc. Film forming compositions containing sucralose
US6929940B1 (en) 2002-08-20 2005-08-16 University Of Florida Research Foundation, Inc. Polynucleotides encoding oxalate decarboxylase from Aspergillus niger and methods of use
WO2004018634A2 (en) 2002-08-20 2004-03-04 University Of Florida Polynucleotide encoding oxalate decarboxylase from aspergillus niger and methods of use
US20080311101A1 (en) * 2005-06-10 2008-12-18 Shenoy Bhami C Method to Reduce Oxalate Concentration by Administration of Oxalate Oxidase Crystals
KR20080035685A (ko) 2005-08-19 2008-04-23 나노시스, 인크. 전자 등급의 금속 나노구조체
CA2645871A1 (en) 2005-12-14 2007-06-21 Oxthera Inc PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING OXALATE-ASSOCIATED DISEASE
JP5558002B2 (ja) * 2005-12-16 2014-07-23 オクセラ インコーポレイテッド シュウ酸塩低減化のための組成物および方法
RU2009107184A (ru) 2006-08-02 2010-09-10 Элтус Фармасьютикалз Инк. (Us) Кристаллизованная оксалатдекарбоксилаза и способы применения
WO2009087826A1 (ja) * 2008-01-04 2009-07-16 Amano Enzyme Inc. シュウ酸脱炭酸酵素の生産に利用される組換え発現プラスミドベクター及び組換え菌、並びに組換えシュウ酸脱炭酸酵素の生産方法
US8431122B2 (en) * 2009-07-02 2013-04-30 Oxthera Intellectual Property Ab Purification and isolation of recombinant oxalate degrading enzymes and spray-dried particles containing oxalate degrading enzymes
WO2011066282A2 (en) * 2009-11-25 2011-06-03 Captozyme, Llc Methods and compositions for treating oxalate-related conditions
CN102492683B (zh) * 2011-12-01 2013-06-12 南宁奕德环境科技有限公司 一种交联草酸脱羧酶聚集体的制备方法
US9520794B2 (en) 2012-07-25 2016-12-13 Philips Lighting Holding B.V Acceleration of output energy provision for a load during start-up of a switching power converter
JP6574414B2 (ja) * 2013-06-07 2019-09-11 アレナ ファーマシューティカルズ, インコーポレイテッド 透析のための組成物、方法、および器具
CN104606100A (zh) 2015-01-12 2015-05-13 德利宝(广州)香料有限公司 一种含洋甘菊复配杭白菊提取物香精的牙膏及其制备方法

Also Published As

Publication number Publication date
AU2021200688A1 (en) 2021-03-04
US20180362955A1 (en) 2018-12-20
AU2021200688B2 (en) 2023-04-20
EP3277099A4 (en) 2018-10-24
EP3277099B1 (en) 2023-11-08
EP3277099A2 (en) 2018-02-07
CA2984763A1 (en) 2016-10-06
US20220298497A1 (en) 2022-09-22
CN107960105A (zh) 2018-04-24
AU2016244121A1 (en) 2017-11-23
AU2016244121B2 (en) 2020-11-05
CN107960105B (zh) 2025-05-16
EP3277099B9 (en) 2024-05-29
WO2016161455A2 (en) 2016-10-06
KR20180044225A (ko) 2018-05-02
WO2016161455A3 (en) 2016-11-24
US11603524B2 (en) 2023-03-14

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