CN107951830A - Rosemary stem cell extract antioxidant composition and the skin care item containing said composition - Google Patents
Rosemary stem cell extract antioxidant composition and the skin care item containing said composition Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract
The invention discloses a kind of antioxidant composition, and containing rosemary stem cell extract, four-o'clock seed endosperm extract, Herba Lysimachiae foenumgraeci extract, three's mass ratio is (0.6~3.8):(1~6):(0.5~5)；It is component to select rosemary stem cell extract, utilize the active ingredient of rosemary, being capable of activating cell, remove free radical, firm skin, desalinate the anti-aging effects of wrinkle, the stem cell of rosemary has good compatibility to human body, it is easier to be absorbed by the body, growth to Skin Cell has good facilitation, it can accelerate the metabolism of cell, strengthen the vigor of Skin Cell, add grape seed extract at the same time, gadol extract, act synergistically with rosemary stem cell extract, play the synergy synergistic effect of anti-wrinkle, under plurality of Chinese extract synergistic effect, product can be obviously improved skin quality, improve skin elasticity, improving the Reproductive activity of skin reduces the ager process that declines of skin, positive effect is higher than individually addition one of which or two kinds of extracts.
Description
Technical field
The present invention relates to technical field of skin care, is specifically related to rosemary stem cell extract antioxidant composition and contains
The skin care item of said composition.
Background technology
It is everyone nature, especially women to like to be beautiful, then as people's the accelerating rhythm of life, operating pressure and life
The increasingly increase of pressure living, and environmental pollution and the careless reason of diet, the growth at simultaneous age, the skin of people
Skin gradually appears many problems, and such as originally coloured and dazzling it is more and more gradually to become long spot, wrinkle on the face, therefore to very much
Women brings puzzlement.
Wrinkle is skin aging as a result, it is the mark that bodily fuctions fall into a decline wrinkle occur, in general, if do not noted
Meaning maintenance, women started wrinkle after 28 years old and increase, and the age is bigger, and wrinkle is more.If malnutritive or psychological burden
Weight, wrinkle can also occur in advance.Wrinkle directly affects the appearance of face.But the tip of the brow is unawares climbed up.Wrinkle is beauty
The crow's feet of formidable enemy, especially canthus can most show the aging of a people.In a sense, the wrinkle of skin is good for human body
Health and longevity there is no big harm.However, but directly affected for beauty and human external image.The original formed on wrinkle
Cause, can say that opinions vary so far, the following origin cause of formation may be had by summing up：1st, loss of moist increases：With advancing age, table
Skin at dermis with flattening, and epidermis is thinning, surface area increase, accelerates moisture of skin volatilization, loses and increase；2nd, cuticula from
So moist factor content, which is reduced, causes skin hydration ability to decline：Since hydratability reduces, skin is difficult to keep normal moisture,
And skin is set to gradually appear fine wrinkles.Further increase and deepen with wrinkle, be continuously increased skin surface product, moisture
Forfeiture is more serious, has dry skin at this time, and wrinkle aggravates；3rd, with the growth at itself age and the influence of external environment, especially
It is ultraviolet irradiation, people's interior free yl increases, and includes active oxygen radical (ROS) with the most close free radical of Senescence
With active carbonyl compound (RCS), both the unstable molecule of high activity, ROS are easy to the reaction of other molecules, damage carefully
Born of the same parents, the accessory substance of its human normal reaction, but external factor such as ultraviolet, environmental toxin and pollution can accelerate its generation, its
Reaction is crosslinked with structural proteins such as skin collagens, causes skin wrinkle occur, and RCS is formed by ROS, its concentration
Rise can accelerate the process of skin senescence, it can occur series reaction with structural proteins, enzyme and DNA and produce adduction
Thing, causes the generation of all kinds of skin problems.
Plant stem cell (plant stem cell) is undifferentiated cell, has very strong self-renewing and persistently divides
Split ability.Research shows that the skin care item containing stem cell can stimulate cell turnover, promotes collagen secretion.Using dry thin
The effect of born of the same parents is more rapidly more effective than general skin care item.Chinese patent CN 102670438B disclose a kind of anti-aging beauty-care shield
Skin product, containing plant stem cell active matter 0.01~3wt% of 0.001~3wt%, Dragosine carnosine, the plant does carefully
Cytoactive thing is PhytocelltecTMMalusDomestica apples stem cell, PhytocelltecTMSolarVitis grapes
Stem cell, Phy tocell te cTM Al pR ose rose leafs stem cell, Phy tocell te cTM Arga n nuts are done
At least one of cell, RegenistemRiceAp red rice stem cells.The cosmetics and skincare product has improvement skin quality, improves skin
The effect of elasticity.
The content of the invention
A kind of anti-oxidant skin care item and preparation method thereof are provided it is an object of the invention to overcome the above problem, the antioxygen
Change composition and be directed to skin senescence problem, using the mutual synergistic effect of the active ingredient of plurality of Chinese extract, effectively remove
Wrinkle, reaches anti-aging effects.
To achieve the above object, the present invention adopts the technical scheme that a kind of antioxidant composition, is done carefully containing rosemary
Born of the same parents' extract, four-o'clock seed endosperm extract, Herba Lysimachiae foenumgraeci extract, three's mass ratio are (0.6~3.8):(1~6):(0.5
~5).
Preferably, containing rosemary stem cell extract, four-o'clock seed endosperm extract, Herba Lysimachiae foenumgraeci extract, three
Mass ratio is (0.8~3):(1.2~5):(0.6~4).
Preferably, containing rosemary stem cell extract, four-o'clock seed endosperm extract, Herba Lysimachiae foenumgraeci extract, three
Mass ratio is (1~2.5):(1.8~4):(1~3).
Preferably, containing rosemary stem cell extract, four-o'clock seed endosperm extract, Herba Lysimachiae foenumgraeci extract, three
Mass ratio is (1.2~2.5):(2~4):(1.5~3).
Preferably, containing rosemary stem cell extract, four-o'clock seed endosperm extract, Herba Lysimachiae foenumgraeci extract, three
Mass ratio is (1.2~1.8):(2~3):(1.5~2).
Preferably, containing rosemary stem cell extract, four-o'clock seed endosperm extract, Herba Lysimachiae foenumgraeci extract, three
Mass ratio is 1.2:2:1.5.
Preferably, containing rosemary stem cell extract, four-o'clock seed endosperm extract, Herba Lysimachiae foenumgraeci extract, three
Mass ratio is 1.8:3:2.
Preferably, containing rosemary stem cell extract, four-o'clock seed endosperm extract, Herba Lysimachiae foenumgraeci extract, three
Mass ratio is 2.5:4:3.
A kind of anti-oxidant skin care item, including the antioxidant composition.
Preferably, the component of following mass percent is included, the antioxidant composition 10~25%, monoglyceride 5~
10%th, vaseline 2~3%, dimethicone 4~8%, glycerine 4~10%, mixed alcohol 5~15%, 4~6%, 1,3- fourth of white oil
Glycol 10~20%, card ripple 940 0.1~0.5%, potassium sorbate 0.1~0.5%, balance deionized water.
Anti-oxidant skin care item main component and effect are as follows used in the present invention：
Rosemary：Rosmarinus officinalis extract, can Scavenger of ROS and free radical, effectively suppression lipid oxygen as antioxidant
Change, rich in methoxy flavone, L ascorbic acid, rosmanol, table rosmanol, different rosmanol in rosemary, pass through diastole blood
Pipe effect activation skin microcirculation, so as to cause a large amount of rows that vein is detained and siltation is fatty to be rushed down.Suppress lipid to penetrate into, can suppress
Phosphodiesterase activity, promotes lipolysis, improves free-fat concentration, promotes the mobility of siltation fat, dredges skin blood
Liquid circulates, and blocks the congestion of blood vessel to reach the effect for slowing down skin aging from contraction and anti-oxidation function.
It is raw material that the present invention, which selects the stem cell of rosemary, and plant stem cell includes the institute on development of plants and growth
There is formula, possess the cell of eternal life power, be the root (origin) of plant life power.Plant stem cell, which is present in, to be referred to as
In the special tectonic of separate living tissue, there is very surprising power of regeneration.These make the primary raw material and source of born of the same parents' metabolism,
Dormancy stem cell can be quickly activated, promotes stem cell self-regeneration renewal, the first viability of reduction epidermal stem cells, makes Skin Cell
It is newborn in a steady stream, so as to reach lifting, firm skin, desalinate the anti-aging effects of wrinkle, while can be easier to be absorbed by the skin
The nutritional ingredient of plant；Accelerate human metabolism.
Four-o'clock seed endosperm：Four-o'clock, also known as Radix primulae maximowiczii, are a kind of herbage flower plants, its seed production is higher, can
It is used as medicine, medicinal entitled " native kaempferia galamga ", cold water tune farinaceous albumen applies face, can control macle acne.Contain reed in four-o'clock seed endosperm
A variety of skin-protecting face nursing components such as fourth (rutin or cloud perfume (or spice) glucoside), Quercetin, Kaempferol, cinnamic acid.Rutin has anti-inflammatory, disease-resistant
Poison, maintains vascular resistance, reduces its permeability, reduces brittleness, keeps and recovers the effect such as normal elasticity of capillary；Mongolian oak
Pi Su has lowering blood pressure and blood fat, the release for suppressing platelet aggregation and serotonin (5-HT), suppresses the effect such as carcinogenic promoting agent；
Kaempferol has obvious antibacterial, anti-inflammatory, anticancer, anti-oxidant, antiulcer and other effects；Cinnamic acid has suppression to form casein amino acid enzyme
Effect, have certain insulating effect to ultraviolet, foxiness can be made to shoal, in addition disappear.Cinnamic acid also has significant antioxygen
Change effect, the effect of fine is had for slow down wrinkle.
Lavender：Lavender category Labiatae lavender category, originates in Mediterranean, throughout Europe and Oceania archipelago,
Planted extensively in Britain and Yugoslavia, present Yunnan successful introduction afterwards.Herba Lysimachiae foenumgraeci extract has DPPH certain removing
Ability, its antioxidation is close with Vc, and the Herba Lysimachiae foenumgraeci extract of 2.0mg/ml up to 91.48%, shows the clearance rate of DPPH
Herba Lysimachiae foenumgraeci extract has good antioxidation activity.
Beneficial effects of the present invention：It is component that the present invention, which selects rosemary stem cell extract, utilizes the effective of rosemary
Component, can activating cell, remove free radical, firm skin, desalinate wrinkle anti-aging effects, using the stem cell of rosemary
There is good compatibility to human body, it is easier to be absorbed by the body, the growth to Skin Cell has good facilitation, can
To accelerate the metabolism of cell, strengthen the vigor of Skin Cell, while add with whitening, skin-active, oxygen freedom can be reduced
Base four-o'clock seed endosperm extract, lavender, act synergistically with rosemary stem cell extract, play the synergy of anti-wrinkle
Synergistic effect, under plurality of Chinese extract synergistic effect, product can be obviously improved skin quality, improve skin elasticity, improve skin
The Reproductive activity of skin reduces the ager process that declines of skin, and positive effect is higher than individually addition one of which or two kinds of extracts.
Embodiment
To better illustrate the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present invention
It is described further.
A kind of antioxidant composition, carries containing rosemary stem cell extract, four-o'clock seed endosperm extract, lavender
Thing is taken, three's mass ratio is (0.6~3.8):(1~6):(0.5~5).
Skin care item containing antioxidant composition, include the component of following mass percent, above-mentioned Chinese medicine anti-oxidation composition
10~25%, monoglyceride 5~10%, vaseline 2~3%, dimethicone 4~8%, glycerine 4~10%, mixed alcohol 5~15%,
White oil 4~6%, 1,3-BDO 10~20%, card ripple 940 0.1~0.5%, triethanolamine adjust pH5-7, potassium sorbate in right amount
0.1~0.5%, balance deionized water.
The preparation method of above-mentioned skin care item, comprises the following steps：
1) preparation of rosemary stem cell extract：A) rosemary stem apex is taken, is rinsed 15~20 minutes, alcohol disinfecting, then
With mercuric chloride liquid disinfectant 10~after twenty minutes, aseptic water washing is for several times；B) by after sterilizing rosemary stem apex with vaccinating lancet peel off shape
Stratification, bast, cortex and epidermal tissue, abandon xylem and marrow, the tissue of acquisition are seeded to fresh inducing culture
In, inoculation 10cm is organized with every 1g2The density of inducing culture be inoculated with, 25 DEG C of continuous cultures 10 in controlled darkroom
My god, obtain Cambium tissue；C) regenerated Cambium tissue and its hetero-organization are separated, inoculation solid medium is organized with every 1g
10cm2Inducing culture density, by it is regenerated formation tissue be seeded in fresh inducing culture, in controlled darkroom
Interior 25 DEG C are continuously cultivated 10 days, obtain callus；D) 200ml proliferated culture mediums, sterilizing are added in the triangular flask of 1000ml
20g, the bead of diameter 0.5cm of processing, 10g callus is moved in triangular flask, and triangular flask is placed in 25 DEG C, 120r/
Cultivated on the shaking table of min, be irradiated 10min with the incandescent lamp of 20w per hour, the 7th day, add fresh 400ml liquid
Body culture medium to cell density for wherein cell density 1 × 105/ ml, then proceedes to culture 7 days, after culture with 100 purposes not
Become rusty steel screen filtration, removes cell mass, residue etc., obtains rosemary cell suspension；E) rosemary cell suspending liquid is moved into 20L
Large-scale culture is carried out in bioreactor, bioreactor accommodates the proliferated culture medium of 5L, and culture adds 10L's on the 7th day
Proliferated culture medium, cell suspending liquid is obtained after continuing culture.F) rosemary stem cell suspension is obtained in collection step e), uses 1um
Filter filters, and removes culture medium, harvests the cell of retention；And by cell be put into -80 DEG C superfreeze 2 it is small when, then
Take out and thaw 30 minutes, repeat aforesaid operations 5 times, after last time thaw at RT, with sonicator smudge cells, filtering
After device filtering, filtrate is collected, in being concentrated in rotating vacuum evaporator, you can obtain rosemary stem cell extract.
Inducing culture：NAA0.5mg/L+BA 2.0mg/L and caseinhydrolysate 1mg/L+MS solid mediums, pH value are
6.0；Proliferated culture medium：2,4-D 2.5mg/L+BA1.5mg/L+ caseinhydrolysates 1mg/L and activated carbon 1mg/L+MS liquid are trained
Support base；PH value is 6.0.
2) first carried with 1,3-BDO and portions of de-ionized water dissolving rosemary stem cell extract, four-o'clock seed endosperm
Thing, Herba Lysimachiae foenumgraeci extract are taken, filtering is stand-by；
3) white oil, vaseline, monoglyceride mix alcohol, and 75 DEG C -80 DEG C of dimethicone stirs evenly；
4) remaining deionized water, glycerine, card ripple 940,75 DEG C -80 DEG C of preservative stir evenly；
5) both the above mixture is successively pumped into emulsification pot, homogeneous 3 minutes, adds triethanolamine and adjust pH5-7 in right amount；
6) stirring be cooled to 40 DEG C, add filtered rosemary stem cell extract, four-o'clock seed endosperm extract,
Herba Lysimachiae foenumgraeci extract, stirs evenly, and is cooled to room temperature.
Embodiment 1
A kind of antioxidant composition, carries containing rosemary stem cell extract, four-o'clock seed endosperm extract, lavender
Thing is taken, three's mass ratio is 0.6:1:0.5.
Skin care item containing antioxidant composition, include the component of following mass percent, above-mentioned Chinese medicine anti-oxidation composition
10%th, monoglyceride 5%, vaseline 2%, dimethicone 4%, glycerine 4%, mixed alcohol 5%, white oil 4%, 1,3-BDO
10%th, card ripple 940 0.1%, triethanolamine adjust pH5-7, potassium sorbate 0.1%, balance deionized water in right amount.The skin care item system
Preparation Method is same as described above.
Embodiment 2
A kind of antioxidant composition, carries containing rosemary stem cell extract, four-o'clock seed endosperm extract, lavender
Thing is taken, three's mass ratio is 0.8:1.2:0.6.
Skin care item containing antioxidant composition, include the component of following mass percent, above-mentioned Chinese medicine anti-oxidation composition
12%th, monoglyceride 6%, vaseline 2.2%, dimethicone 5%, glycerine 4.5%, mixed alcohol 6%, white oil 5%, 1,3-BDO
13%th, card ripple 940 0.3%, triethanolamine adjust pH5-7, potassium sorbate 0.1~0.5%, balance deionized water in right amount.The skin care
Product preparation method is same as Example 1.
Embodiment 3
A kind of antioxidant composition, carries containing rosemary stem cell extract, four-o'clock seed endosperm extract, lavender
Thing is taken, three's mass ratio is 1:1.8:1.
Skin care item containing antioxidant composition, include the component of following mass percent, above-mentioned Chinese medicine anti-oxidation composition
15%th, monoglyceride 6.5%, vaseline 2.5%, dimethicone 6%, glycerine 5%, mixed alcohol 8%, white oil 4.5%, 1,3- fourths two
Alcohol 15%, card ripple 940 0.3%, triethanolamine adjust pH5-7, potassium sorbate 0.3%, balance deionized water in right amount.
Embodiment 4
A kind of antioxidant composition, carries containing rosemary stem cell extract, four-o'clock seed endosperm extract, lavender
Thing is taken, three's mass ratio is 1.2:2:1.5.
Skin care item containing antioxidant composition, include the component of following mass percent, above-mentioned Chinese medicine anti-oxidation composition
18%th, monoglyceride 7.5%, vaseline 2.5%, dimethicone 6.5%, glycerine 6%, mixed alcohol 10%, white oil 5%, 1,3- fourths
Glycol 16%, card ripple 940 0.3%, triethanolamine adjust pH5-7, potassium sorbate 0.4%, balance deionized water in right amount.
Embodiment 5
A kind of antioxidant composition, carries containing rosemary stem cell extract, four-o'clock seed endosperm extract, lavender
Thing is taken, three's mass ratio is 1.8:3:2.
Skin care item containing antioxidant composition, include the component of following mass percent, above-mentioned Chinese medicine anti-oxidation composition
20%th, monoglyceride 8%, vaseline 2.6%, dimethicone 6%, glycerine 7.5%, mixed alcohol 12%, white oil 5.5%, 1,3- fourths
Glycol 18%, card ripple 940 0.4%, triethanolamine adjust pH5-7, potassium sorbate 0.3%, balance deionized water in right amount.
Embodiment 6
A kind of antioxidant composition, carries containing rosemary stem cell extract, four-o'clock seed endosperm extract, lavender
Thing is taken, three's mass ratio is 2.5:4:3.
Skin care item containing antioxidant composition, include the component of following mass percent, above-mentioned Chinese medicine anti-oxidation composition
22%th, monoglyceride 8.5%, vaseline 2.5%, dimethicone 6.4%, glycerine 8%, mixed alcohol 13%, white oil 5%, 1,3- fourths
Glycol 17.5%, card ripple 940 0.4%, triethanolamine adjust pH5-7, potassium sorbate 0.4%, balance deionized water in right amount.
Embodiment 7
A kind of antioxidant composition, carries containing rosemary stem cell extract, four-o'clock seed endosperm extract, lavender
Thing is taken, three's mass ratio is 3:5:4.
Skin care item containing antioxidant composition, include the component of following mass percent, above-mentioned Chinese medicine anti-oxidation composition
25%th, monoglyceride 9%, vaseline 2.8%, dimethicone 7%, glycerine 8.5%, mixed alcohol 14%, white oil 6%, 1,3- fourths two
Alcohol 18%, card ripple 940 0.5%, triethanolamine adjust pH5-7, potassium sorbate 0.5%, balance deionized water in right amount.
Embodiment 8
A kind of antioxidant composition, carries containing rosemary stem cell extract, four-o'clock seed endosperm extract, lavender
Thing is taken, three's mass ratio is 3.8:6:5.
Skin care item containing antioxidant composition, include the component of following mass percent, above-mentioned Chinese medicine anti-oxidation composition
24%th, monoglyceride 10%, vaseline 3%, dimethicone 8%, glycerine 10%, mixed alcohol 15%, white oil 5%, 1,3-BDO
20%th, card ripple 940 0.4%, triethanolamine adjust pH5-7, potassium sorbate 0.4%, balance deionized water in right amount.
Control group 1
A kind of anti-oxidant skin care item, include the component of following mass percent, and rosemary stem cell extract 18%, list are sweet
Ester 7.5%, vaseline 2.5%, dimethicone 6.5%, glycerine 6%, mixed alcohol 10%, white oil 5%, 1,3-BDO 16%,
Card ripple 940 0.3%, triethanolamine adjust pH5-7, potassium sorbate 0.4%, balance deionized water in right amount.The skin care item preparation method
It is same as Example 1.
Control group 2
A kind of anti-oxidant skin care item, include the component of following mass percent, four-o'clock seed endosperm extract 18%, list
Sweet ester 7.5%, vaseline 2.5%, dimethicone 6.5%, glycerine 6%, mixed alcohol 10%, white oil 5%, 1,3-BDO
16%th, card ripple 940 0.3%, triethanolamine adjust pH5-7, potassium sorbate 0.4%, balance deionized water in right amount.The skin care item system
Preparation Method is same as Example 1.
Control group 3
A kind of anti-oxidant skin care item, include the component of following mass percent, Herba Lysimachiae foenumgraeci extract 18%, monoglyceride
7.5%th, vaseline 2.5%, dimethicone 6.5%, glycerine 6%, mixed alcohol 10%, white oil 5%, 1,3-BDO 16%, card
Ripple 940 0.3%, triethanolamine adjust pH5-7, potassium sorbate 0.4%, balance deionized water in right amount.The skin care item preparation method with
Embodiment 1 is identical.
Control group 4
A kind of anti-oxidant skin care item, include the component of following mass percent, composite skin care product 18%, monoglyceride
7.5%th, vaseline 2.5%, dimethicone 6.5%, glycerine 6%, mixed alcohol 10%, white oil 5%, 1,3-BDO 16%, card
Ripple 940 0.3%, triethanolamine adjust pH5-7, potassium sorbate 0.4%, balance deionized water in right amount.The skin care item preparation method with
Embodiment 1 is identical.
The composite skin care product of this control group is rosemary stem cell extract, four-o'clock seed endosperm extract, both
Mass ratio is 1.2:2.
Control group 5
A kind of anti-oxidant skin care item, include the component of following mass percent, composite skin care product 18%, monoglyceride
7.5%th, vaseline 2.5%, dimethicone 6.5%, glycerine 6%, mixed alcohol 10%, white oil 5%, 1,3-BDO 16%, card
Ripple 940 0.3%, triethanolamine adjust pH5-7, potassium sorbate 0.4%, balance deionized water in right amount.The skin care item preparation method with
Embodiment 1 is identical.
The composite skin care product of this control group is rosemary stem cell extract, Herba Lysimachiae foenumgraeci extract, both are at mass ratio
1.2:1.5。
Control group 6
A kind of anti-oxidant skin care item, include the component of following mass percent, composite skin care product 18%, monoglyceride
7.5%th, vaseline 2.5%, dimethicone 6.5%, glycerine 6%, mixed alcohol 10%, white oil 5%, 1,3-BDO 16%, card
Ripple 940 0.3%, triethanolamine adjust pH5-7, potassium sorbate 0.4%, balance deionized water in right amount.The skin care item preparation method with
Embodiment 1 is identical.
The composite skin care product of this control group is four-o'clock seed endosperm extract, Herba Lysimachiae foenumgraeci extract, both mass ratioes
For 2:1.5.
Control group 7
A kind of anti-oxidant skin care item, include the component of following mass percent, composite skin care product 18%, monoglyceride
7.5%th, vaseline 2.5%, dimethicone 6.5%, glycerine 6%, mixed alcohol 10%, white oil 5%, 1,3-BDO 16%, card
Ripple 940 0.3%, triethanolamine adjust pH5-7, potassium sorbate 0.4%, balance deionized water in right amount.The skin care item preparation method with
Embodiment 1 is identical.
The composite skin care product of this control group is rosemary stem cell extract, four-o'clock seed endosperm extract, smokes clothing
Careless extract, three's mass ratio are 0.3:0.7:0.2.
Control group 8
A kind of anti-oxidant skin care item, include the component of following mass percent, composite skin care product 18%, monoglyceride
7.5%th, vaseline 2.5%, dimethicone 6.5%, glycerine 6%, mixed alcohol 10%, white oil 5%, 1,3-BDO 16%, card
Ripple 940 0.3%, triethanolamine adjust pH5-7, potassium sorbate 0.4%, balance deionized water in right amount.The skin care item preparation method with
Embodiment 1 is identical.
The composite skin care product of this control group is rosemary stem cell extract, four-o'clock seed endosperm extract, smokes clothing
Careless extract, three's mass ratio are 4:7:6.
Experiment effect
1st, guinea pig skin stimulation test
1~8 composite skin care product of 0.5g embodiments is respectively taken, being diluted to 100g using deionized water is configured to given the test agent.
Given the test agent using skin irritation test method (《Cosmetics health specification》2007 editions toxicology test methods) tested.
Experimental animal：Cavy weight 250g~300g.
Experimental result：Through 14 days Skin Irritation Tests, stimulate the reaction is had no.
2nd, sample Antioxidation in vitro
By embodiment 1~8, control group 1~8 with DPPH (final concentration of 100M) hybrid reaction, sets 3 repetitions respectively
Hole, while the blank control without extracting solution and vitamin E positive control are set, when 30 DEG C of reactions 1 are small, microplate reader measure OD
Value, Detection wavelength 515nm, is calculated antioxygen rate, the results are shown in Table 2.
Antioxygen rate (%)=(1- experimental ports OD515nm/ blank well OD515nm) × 100%；
1 sample Antioxidtive Activities in Vitro of table
As shown in Table 3, three kinds of the anti-apolexis composition of the embodiment of the present invention 1~8 is respectively provided with good antioxidation in vitro
Ability, it is suitable with the antioxygen rate of vitamin E, interior free yl can be effectively removed, plays the role of preventing skin senescence,
Wherein with the best results of embodiment 4~6.
Control group 1~3 is respectively only using rosemary stem cell extract, four-o'clock seed endosperm extract, lavender
The anti-aging skin care product of extract, above-mentioned 1~3 condition same as Example 4 of control group, it can be seen that be used alone in three kinds
A kind of extract, there is certain anti-senescence function, but free radical scavenging activity is substantially less than the present invention, and imitate with vitamin E
Fruit differs greatly, and control group 4~6 is the skin care item obtained using two kinds in three kinds of extracts any combination, with embodiment 4 its
His condition is identical, it can be seen that relative to extract is used alone, its clearance rate has lifting, but its effect also exists with the present invention
Difference, illustrating the composition of the present invention needs three to act synergistically down jointly, can just reach significant anti-wrinkle effect.
And control group 7~8 is to select identical component, under the conditions of identical preparation method, its formula rate is in the present invention
Specific proportion outside, its effect be nothing like the present invention effect, it was demonstrated that, composition of the invention is only specific
The significant anti-aging effects of competence exertion in ratio.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
God and any modification, equivalent substitution, improvement and etc. within principle, done, should be included within the scope of protection of the invention.
Claims (10)
1. a kind of antioxidant composition, it is characterised in that extracted containing rosemary stem cell extract, four-o'clock seed endosperm
Thing, Herba Lysimachiae foenumgraeci extract, three's mass ratio are (0.6~3.8):(1~6):(0.5~5).
2. antioxidant composition according to claim 1, it is characterised in that contain rosemary stem cell extract, purple jasmine
Jasmine seed endosperm extract, Herba Lysimachiae foenumgraeci extract, three's mass ratio are (0.8~3):(1.2~5):(0.6~4).
3. antioxidant composition according to claim 1, it is characterised in that contain rosemary stem cell extract, purple jasmine
Jasmine seed endosperm extract, Herba Lysimachiae foenumgraeci extract, three's mass ratio are (1~2.5):(1.8~4):(1~3).
4. antioxidant composition according to claim 1, it is characterised in that contain rosemary stem cell extract, purple jasmine
Jasmine seed endosperm extract, Herba Lysimachiae foenumgraeci extract, three's mass ratio are (1.2~2.5):(2~4):(1.5~3).
5. antioxidant composition according to claim 1, it is characterised in that contain rosemary stem cell extract, purple jasmine
Jasmine seed endosperm extract, Herba Lysimachiae foenumgraeci extract, three's mass ratio are (1.2~1.8):(2~3):(1.5~2).
6. antioxidant composition according to claim 1, it is characterised in that contain rosemary stem cell extract, purple jasmine
Jasmine seed endosperm extract, Herba Lysimachiae foenumgraeci extract, three's mass ratio are 1.2:2:1.5.
7. antioxidant composition according to claim 1, it is characterised in that contain rosemary stem cell extract, purple jasmine
Jasmine seed endosperm extract, Herba Lysimachiae foenumgraeci extract, three's mass ratio are 1.8:3:2.
8. antioxidant composition according to claim 1, it is characterised in that contain rosemary stem cell extract, purple jasmine
Jasmine seed endosperm extract, Herba Lysimachiae foenumgraeci extract, three's mass ratio are 2.5:4:3.
9. a kind of anti-oxidant skin care item, it is characterised in that including claim 1 to 8 any one of them antioxidant composition.
10. anti-oxidant skin care item according to claim 9, it is characterised in that include the component of following mass percent, institute
State antioxidant composition 10~25%, monoglyceride 5~10%, vaseline 2~3%, dimethicone 4~8%, glycerine 4~
10%th, alcohol 5~15%, white oil 4~6%, 1,3-BDO 10~20%, card ripple 940 0.1~0.5%, potassium sorbate 0.1 are mixed
~0.5%, balance deionized water.
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| CN103385832A (en) * | 2013-07-24 | 2013-11-13 | 云南西草资源开发有限公司 | Anti-aging cosmetic taking lavender extract as main active ingredient |
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| CN105748343A (en) * | 2016-02-25 | 2016-07-13 | 广州市科玮生物技术有限公司 | Natural plant extract composition and application thereof in cosmetics |
| CN106265301A (en) * | 2016-08-24 | 2017-01-04 | 刘艺鹏 | Sun screen containing Flos Matricariae chamomillae |
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