CN101836944A - Composition of plant extracts and application in skin whitening and moisture preservation - Google Patents
Composition of plant extracts and application in skin whitening and moisture preservation Download PDFInfo
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Abstract
The invention relates to a composition of plant extracts and application thereof in skin whitening and moisture preservation. The composition comprises the following active ingredients in percentage by weight: 5 to 90 percent of green tea extract, 5 to 50 percent of ginkgo leaf extract and 5 to 45 percent of centella extract, wherein the composition accounts for 0.5 to 20 percent when applied to preparing external products of skin, and the composition is uniformly mixed with medically-acceptable excipients or carriers in proportion to prepare products in forms of gel, cream, serosity, aqueous solution agents, emulsions or solids. The composition has the effects on skin whitening and moisture preservation without adding moisture preserving components; compared with products with similar application, the composition has stronger effects on skin whitening and moisture preservation and smaller dosage; the composition is safe, has no toxic or side effect, has low allergy rates and inflammation probability, penetrates into skin dermis, does not change the normal apoptosis process of cells, restrains tyrosinase, dopachrome tautomerase, DHICA oxidase and endothelin appropriately and balances the metabolism of melanin, so that the color and luster of the skin is more natural; and in addition, the generated skin whitening effect is definite, and the composition is convenient to use in cosmetics.
Description
Technical field
The present invention relates to cosmetics, the medicine of external preparation for skin product, specifically is that a kind of composition of plant extracts that is used for whitening moisturizing reaches the application to whitening moisturizing.
Technical background
The color of human skin depends on melanic content and distribution, and the structure function of melanocyte and quantity directly influence melanic content in the skin, also is to produce melanic determiner.The principle of whitening mainly is to influence tryrosinase, melanocyte and melanic metabolism.On medicine, find to have only hydroquinone (hydroq uinone) to be regarded as the only regular therapy of whitening at present temporarily, yet there are some researches show that there is carcinogenic possibility (foreign medical science hygiology fascicle equally in hydroquinone, 1994,21 (6): 321-324), medicine solves the skin-whitening problem and relies on skin-lightening cosmetic mostly at present, the comparatively ideal main activated feedstock of whitening effect has arbutin, kojic acid and derivant thereof, Radix Glycyrrhizae extract, VC and derivant thereof, VE etc., but general external whitening product can only solve the local skin epidermal area, can't arrive skin corium, can not take good care of by the inherence and reach comprehensive effect of improving whole skin, the kind treatment of the science of compatibility is fastidious between effective threshold doseag of the active component of Tian Jiaing and each composition in addition, and white-skinned face function is limited mostly.
It is one of pathomechanism of old and feeble outward appearance that the skin water content reduces gradually, when cuticular water content is lower than 10%, xerosis cutis, desquamation, the crack appears in the horn cell layer that imbricate is arranged in parallel, skin is subjected to the erosion of external environment physical factor easily, and the water in the skin, electrolyte be evaporation or loss easily also.Skin moisture-keeping is the most important basic means that guarantee cuticular barrier function and cosmetology.Preserve moisture product mainly by preventing that the moisture of losing and absorb external environment of moisture reaches the purpose that skin includes certain moisture in the skin, comparatively the active component of preserving moisture of approval is a bionical dose of class at present, as ceramide, hyaluronic acid, pyrrolidone carboxylic acid sodium etc., after skin absorbs, make it to be not easy volatilization performance moisture-keeping function thereby can combine with the free water in the skin, subject matter is the specific examples of such components unstable chemcial property, content in product system often gradually reduces because of internal and external factor, can't reach effective threshold value, the moistening effect of itself is not remarkable.
Tea (Camelllia sinensis) belongs to Theaceae, it is the leaf of dicotyledon Camellia sinensis, green tea is the tea without fermentation, more reservation the natural materials in the bright leaf, for other teas can't be obtained, be the maximum consumer beverage of ating the second place in the world, the medical value of centuries is arranged at the nations of China and India.The main effective ingredient of green tea extract is a polyphenols, account for 22%～30% of dry weight of tea leaves, mainly form by four big class materials such as catechin, flavonoid, phenolic acids, anthocyanidin, aspect medical science, can prevent and treat the effect of cardiovascular disease, anticancer mutation, multiple effects such as blood sugar lowering, blood pressure lowering, antiviral are arranged.Green tea extract has inhibitory action to Caspase, in conjunction with its non-oxidizability with to the scavenging action of human free radical, often is used for cosmetics outward and makes the defying age additive.Green tea extract still is a kind of good natural skin whitening agent, and the activity of tryrosinase and peroxidase is had inhibitory action, to engulfing melanic macrophage activation is arranged simultaneously, and two aspect combineds effect have a good inhibition effect to melanic.Do not see the dangerous report of green tea extract external.
Semen Ginkgo (Ginkgo Biloba L.) belongs to the monotypic species of gymnosperm Ginkgoaceae, is the special product plant of China.Semen Ginkgo is edible and people's medicine is ancient, beginning is stated from Ming Dynasty's " daily book on Chinese herbal medicine ", " Bencao Pinhui Jingyao made by the emperor order " and Compendium of Material Medica, Folium Ginkgo is accommodated in the Pharmacopoeia of the People's Republic of China (version in 2005) as Chinese medicine, wherein carries: " nature and flavor with return through: sweet, bitter, puckery, flat.GUIXIN, lung meridian ".Cure mainly: astringe the lung, relieving asthma, blood circulation promoting and blood stasis dispelling, pain relieving.Be used for cough and asthma due to lung deficiency, coronary heart disease, angina pectoris, hyperlipidemia.Contain multiple biological activity in the Folium Ginkgo extract, mainly comprise flavone compound, Semen Ginkgo polysaccharide, bilobalide.Prove that through clinical medicine Folium Ginkgo extract energy blood circulation promoting improves the cardiovascular effect, removes superoxide ion in the body, the generation of prophylaxis of tumours etc.
Herba Centellae (Centella asiatica (L) .Urban.) is the dry herb of Umbelliferae Centella plant Herba Centellae, be " the conventional Chinese medicine that Chinese pharmacopoeia is recorded, beginning is stated from Shennong's Herbal, in the external in existing more than 2,000 year of China and the history of curing the disease for oral administration, its nature and flavor hardship, suffering, cold, have the effect of clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, clinically traumatic injury, dermatosiss etc. of being used for the treatment of more.Herba Centellae extract contains plurality of active ingredients, and wherein the main pharmacodynamics composition is asiaticoside, asiaticoside, asiatic acid and Madecassic acid.Clinical practice confirms, asiaticoside has the normal granulation tissue of promotion and forms, activate epithelial tissue, strengthen the reticuloendothelial system function, the healing of accelerated in wounds and chronic ulcer tissue suppresses fibroblast proliferation, reduces synulotic effect (Chinese Chinese medicine information magazine, 2002,9 (8): 81-84).Asiaticoside can effectively suppress the mitosis and the propagation of melanocyte, is dose-effect relationship, can induce the apoptosis of melanocyte or cause death and die; It is synthetic to suppress melanoma cells cheese ammonia enzymatic activity and melanocyte, is that (Chinese combination of Chinese and Western medicine skin cypridology magazine, 2004,3 (1): 7-10), medical applications report does not in this respect have temporarily to be found for a kind of Solu-Eze of no cytotoxicity.
Summary of the invention
The objective of the invention is to overcome above-mentioned deficiency, a kind of low using dosage be provided, strong to the whitening moisturizing effect, with the plant extract of natural plant green tea extract, Folium Ginkgo extract and Herba Centellae extract be active ingredient compositions.
Another object of the present invention is this low using dosage, to the application of the strong composition of plant extracts of whitening moisturizing effect it, be external preparation for skin product of active ingredient and preparation method thereof as compositions with green tea extract, Folium Ginkgo extract, three kinds of extracts of Herba Centellae extract or three kinds of extracts.
Technical scheme of the present invention is, three kinds of active component of green tea extract, Folium Ginkgo extract, Herba Centellae extract united to use form a kind of compositions, and we define said composition is Tinbo.
Green tea extract, Folium Ginkgo extract, Herba Centellae extract three's weight part ratio can be 5%～90%: 5%～50%: 5%～45% in the above-mentioned composition.
Green tea extract, Folium Ginkgo extract, Herba Centellae extract three's weight part ratio also can be preferably 30%～85%: 10%～40%: 5%～30% in the above-mentioned composition.
Green tea extract, Folium Ginkgo extract, Herba Centellae extract three's weight part ratio also can be preferably 40%～80%: 10%～30%: 10%～30% in the above-mentioned composition.
Weight part ratio the best of green tea extract, Folium Ginkgo extract, Herba Centellae extract three can be 80%: 10%: 10% in the above-mentioned composition.
In the above-mentioned compositions, its green tea extract contains the polyhydroxy phenol compounds can be 1%～95% by weight percentage.
In the above-mentioned compositions, Folium Ginkgo extract contains terpenoid and flavonoid can be 20%～90% by weight percentage.
In the above-mentioned compositions, Herba Centellae extract contains Herba Centellae total glycosides can be 10%～95% by weight percentage.
In the above-mentioned compositions, its green tea extract contains the polyhydroxy phenol compounds can be 1%～95% by weight percentage, Folium Ginkgo extract contains terpenoid and flavonoid can be 20%～90% by weight percentage, and Herba Centellae extract contains Herba Centellae total glycosides can be 10%～95% by weight percentage.
The compositions purposes of above-mentioned plant extract it, be applied to the preparation of the external preparation for skin product of whitening skin and preserving moisture, proportionally add each component of above-mentioned plant extract or compositions in the high-speed solid mixer successively, 10 ℃-65 ℃ of whipping temps, mixing time 30 minutes-60 minutes, the powdery product that uniform mixing forms, also can with each component of above-mentioned plant extract or compositions and medically acceptable inert matter or carrier proportionally uniform mixing form the product of gel, cream frost, serosity, water preparation, emulsion or solid form.
Above-mentioned plant extract each component sum or compositions can be 0.5%～20% at the above-mentioned content that is used for the external preparation for skin product of whitening moisturizing.
Above-mentioned plant extract each component sum or compositions can be 10%～20% at the above-mentioned content that is used for the external preparation for skin product of whitening moisturizing.
Above-mentioned plant extract each component sum or compositions can be 10% at the above-mentioned content that is used for the external preparation for skin product of whitening moisturizing.
The external preparation for skin product of whitening skin and preserving moisture of the present invention can be cosmetics, can be medicament.
Each component that both can at first prepare composition of plant extracts of the present invention among the present invention, prepare composition of plant extracts of the present invention then thus, further preparation contains the medicine that is used for whitening moisturizing or the cosmetics of above-mentioned composition, each compositions that also can at first prepare composition of plant extracts of the present invention, directly prepare thus then and contain the cosmetics that are used for whitening moisturizing of above-mentioned composition, and do not need the step of independent preparation composition of plant extracts of the present invention.It will be understood by those skilled in the art that above-mentioned two kinds of methods are equivalent with regard to final products.
Cosmetics transdermal stimulation test (repeatedly) that is used for whitening moisturizing and the skin allergic reaction test that contains above-mentioned composition of plant extracts of the present invention, detect conclusion and be respectively: the skin irritation strength grading belongs to nonirritant; By sensitization strength grading standard, be judged to and do not see skin allergic reaction.
Green tea extract of the present invention, Folium Ginkgo extract and Herba Centellae extract compositions, the use in conjunction of three kinds of active component make each component effect produce synergism, have the humectant energy when whitening, and need not to add in addition preserve moisture composition and protective agent; Stronger to the whitening moisturizing effect with respect to similar purposes product, using dosage is lower; The All Pure Nature material, safe without toxic side effect, irritated rate and inflammation probability are low, go deep into dermal layer of the skin, the recovery by cell viability really reaches skin-active and supports skin, does not change the normal apoptotic program of cell, an amount of three enzymes, one element that suppresses, the melanic metabolism of balance makes skin colour more natural, and the whitening effect that is produced is more definite; Can use known method to add by those skilled in the art be used for the whitening moisturizing cosmetics, uses very convenient.
The specific embodiment
The present invention is further illustrated below in conjunction with embodiment, and following embodiment only is used to illustrate technical scheme of the present invention, but to not restriction of the present invention.
Embodiment one
Plant extract of the present invention is used to prepare the gel of whitening moisturizing, its prescription in 100 parts wherein: 2.5 parts of green tea extracts, 1.25 parts of Folium Ginkgo extract, 1.25 parts of Herba Centellae extracts, 10.0 parts of different nonyl isononyl alcohol esters, 3.0 parts of Sepigel 305 (polyacrylamide), antiseptic are an amount of, all the other are deionized water (being added to 100 parts).
Concrete technological process is: green tea extract, Folium Ginkgo extract, Herba Centellae extract are dissolved in the ester, when being warmed to 30 ℃, add Sepigel 305, under agitation add entry, add antiseptic at last and stir evenly, be cooled to room temperature and get final product.
Embodiment two
Plant extract of the present invention is used to prepare the gel of whitening moisturizing, its prescription in 100 parts wherein: 2.5 parts of green tea extracts, 1.25 parts of Folium Ginkgo extract, 1.25 parts of Herba Centellae extracts, 1.0 parts of Carbopol 940 (carbopol 940), 9.0 parts of propylene glycol, oleyl alcohol ether-201.5 part, 2.0 parts of triethanolamine, EDTA-Na
20.1 part, antiseptic is an amount of, all the other are deionized water (being added to 100 parts).
Concrete technological process is: under quick condition of stirring, Carbopol 940 is sprinkled into the part deionized water lentamente, makes dissolving fully, with residue deionized water dissolving propylene glycol and antiseptic; With the mixture suction vacuum emulsification jar of Carbopol 940 with deionized water, deionized water, propylene glycol and antiseptic are filtered in the adding vacuum emulsification jar again, 75 ℃-80 ℃, stir vacuumize degassing; When above mixture dissolves the uniform mixing component that adds oleyl alcohol ether and green tea extract, Folium Ginkgo extract, Herba Centellae extract when complete, after continuing to stir evenly, add the triethanolamine neutralization, the while evacuation, outgasing to product does not have bubble, is cooled to room temperature and gets final product.
Embodiment three
Plant extract of the present invention is used to prepare the gel of whitening moisturizing, its prescription in 100 parts wherein: 0.2 part of green tea extract, 0.15 part of Folium Ginkgo extract, 0.15 part of Herba Centellae extract, 1.0 parts of Carbopol 940 (carbopol 940), 9.0 parts of propylene glycol, oleyl alcohol ether-201.5 part, 2.0 parts of triethanolamine, EDTA-Na
20.1 part, antiseptic is an amount of, all the other are deionized water (being added to 100 parts).
Concrete technological process is with embodiment two.
Embodiment four
The present invention's plant extract of the present invention is used to prepare the cream frost of whitening moisturizing, its prescription is in 100 parts wherein: 3.0 parts of green tea extracts, 1.5 parts of Folium Ginkgo extract, 0.5 part of Herba Centellae extract, 8.0 parts of white oils, 12.0 parts of white vaseline, 10.0 parts of glyceryl monostearates, 6.0 parts of glycerol, mix that 4.0 parts of alcohol, 18.0 parts of 1,3 butylene glycols, antiseptic are an amount of, all the other are deionized water (being added to 100 parts).Herba Centellae total glycosides content 20% in the Herba Centellae extract, polyhydroxy phenol kind compound content 50% in the green tea extract, terpenoid and flavonoid content 30% in the Folium Ginkgo extract.
Concrete technological process is: use 1,3 butylene glycol and part deionized water dissolving green tea extract, Folium Ginkgo extract, Herba Centellae extract earlier, filter stand-by; White oil, white vaseline, glyceryl monostearate mix alcohol and stir for 75 ℃-80 ℃; The residue deionized water, glycerol, antiseptic stirs for 75 ℃-80 ℃; With above two kinds of mixture suction successively emulsifying pot, homogenizing 5 minutes stirs and is cooled to 40 ℃, adds to filter good green tea extract, Folium Ginkgo extract, Herba Centellae extract, stirs evenly, and is cooled to room temperature and gets final product.
Embodiment five
The present invention's plant extract of the present invention is used to prepare the cream frost of whitening moisturizing, its prescription is in 100 parts wherein: 7 parts of green tea extracts, 2 parts of Folium Ginkgo extract, 1 part of Herba Centellae extract, 3.0 parts of monoglycerides, 3.0 parts in vaseline, 3.0 parts of dimethicones, 2.0 parts of glycerol, mix 5.0 parts of alcohol, 8.0 parts of white oils, 22.0 parts of 1,3 butylene glycols, antiseptic are an amount of, all the other are deionized water (being added to 100 parts).
Concrete technological process is: use 1,3 butylene glycol and part deionized water dissolving green tea extract, Folium Ginkgo extract, Herba Centellae extract earlier, filter stand-by; White oil, vaseline, monoglyceride mix alcohol, and dimethicone stirs for 75 ℃-80 ℃; The residue deionized water, glycerol, antiseptic stirs for 75 ℃-80 ℃; With above two kinds of mixture suction successively emulsifying pot, homogenizing 5 minutes stirs and is cooled to 40 ℃, adds to filter good green tea extract, Folium Ginkgo extract, Herba Centellae extract, stirs evenly, and is cooled to room temperature and gets final product.
Embodiment six
The present invention's plant extract of the present invention is used to prepare the cream frost of whitening moisturizing, its prescription is in 100 parts wherein: 3 parts of green tea extracts, 4 parts of Folium Ginkgo extract, 3 parts of Herba Centellae extracts, 3.0 parts of monoglycerides, 3.0 parts in vaseline, 3.0 parts of dimethicones, 2.0 parts of glycerol, mix 5.0 parts of alcohol, 8.0 parts of white oils, 22.0 parts of 1,3 butylene glycols, antiseptic are an amount of, all the other are deionized water (being added to 100 parts).
Concrete technological process is with embodiment five.
Embodiment seven
The present invention's plant extract of the present invention is used to prepare the emulsion of whitening moisturizing, its prescription is in 100 parts wherein: 18.2 parts of green tea extracts, 1.5 parts of Folium Ginkgo extract, 0.3 part of Herba Centellae extract, 8.0 parts of monoglycerides, 3.0 parts in vaseline, 5.0 parts of dimethicones, 6.0 parts of glycerol, mix 12.0 parts of alcohol, 8.0 parts of white oils, 30.0 parts of 1,3 butylene glycols, 0.30 part of carbopol 940, triethanolamine transfer in right amount that p H5-7, antiseptic are an amount of, all the other are deionized water (being added to 100 parts).
Concrete technological process is: use 1,3 butylene glycol and part deionized water dissolving green tea extract, Folium Ginkgo extract, Herba Centellae extract earlier, filter stand-by; White oil, vaseline, monoglyceride mix alcohol, and dimethicone stirs for 75 ℃-80 ℃; The residue deionized water, glycerol, carbopol 940, antiseptic stirs for 75 ℃-80 ℃; With above two kinds of mixture suction successively emulsifying pot, homogenizing 3 minutes adds triethanolamine and transfers pH5-7 in right amount; Stirring is cooled to 40 ℃, adds to filter good green tea extract, Folium Ginkgo extract, Herba Centellae extract, stirs evenly, and is cooled to room temperature and gets final product.
Embodiment eight
The present invention's plant extract of the present invention is used to prepare the emulsion of whitening moisturizing, its prescription is in 100 parts wherein: 18 parts of green tea extracts, 1.0 parts of Folium Ginkgo extract, 1.0 parts of Herba Centellae extracts, 8.0 parts of monoglycerides, 3.0 parts in vaseline, 5.0 parts of dimethicones, 6.0 parts of glycerol, mix 12.0 parts of alcohol, 8.0 parts of white oils, 30.0 parts of 1,3 butylene glycols, 0.30 part of carbopol 940, triethanolamine transfer in right amount that pH5-7, antiseptic are an amount of, all the other are deionized water (being added to 100 parts).
Concrete technological process is with embodiment seven.
Embodiment nine
The present invention's plant extract of the present invention is used to prepare the emulsion of whitening moisturizing, its prescription is in 100 parts wherein: 15 parts of green tea extracts, 1.5 parts of Folium Ginkgo extract, 0.3 part of Herba Centellae extract, 4.0 parts of monoglycerides, 2.0 parts in vaseline, 4.0 parts of dimethicones, 5.0 parts of glycerol, mix 14.0 parts of alcohol, 7.0 parts of white oils, 16.0 parts of 1,3 butylene glycols, 0.5 part of carbopol 940, triethanolamine transfer in right amount that pH5-7, antiseptic are an amount of, all the other are deionized water (being added to 100 parts).
Concrete technological process is: use 1,3 butylene glycol and part deionized water dissolving green tea extract, Folium Ginkgo extract, Herba Centellae extract earlier, filter stand-by; White oil, vaseline, monoglyceride mix alcohol, and dimethicone stirs for 75 ℃-80 ℃; The residue deionized water, glycerol, carbopol 940, antiseptic stirs for 75 ℃-80 ℃; With above two kinds of mixture suction successively emulsifying pot, homogenizing 3 minutes adds triethanolamine and transfers pH5-7 in right amount; Stirring is cooled to 40 ℃, adds to filter good green tea extract, Folium Ginkgo extract, Herba Centellae extract, stirs evenly, and is cooled to room temperature and gets final product.
Embodiment ten
Plant extract of the present invention is used to prepare the granule of whitening moisturizing, its prescription is in 100 parts wherein: 16.0 parts of green tea extracts, 2.0 parts of Folium Ginkgo extract, 2.0 parts of Herba Centellae extracts,, 4.0 parts of monoglycerides, 2.0 parts in vaseline, 4.0 parts of dimethicones, 5.0 parts of glycerol, mix 14.0 parts of alcohol, 7.0 parts of white oils, 16.0 parts of 1,3 butylene glycols, 0.5 part of carbopol 940, triethanolamine transfer in right amount that pH5-7, antiseptic are an amount of, all the other are deionized water (being added to 100 parts).
Concrete technological process is with embodiment nine.
Embodiment 11
Plant extract of the present invention is used to prepare the granule of whitening moisturizing, its prescription is in 100 parts wherein: 17.0 parts of green tea extracts, 1.0 parts of Folium Ginkgo extract, 2.0 parts of Herba Centellae extracts,, 4.0 parts of monoglycerides, 2.0 parts in vaseline, 4.0 parts of dimethicones, 5.0 parts of glycerol, mix 14.0 parts of alcohol, 7.0 parts of white oils, 16.0 parts of 1,3 butylene glycols, 0.5 part of carbopol 940, triethanolamine transfer in right amount that pH5-7, antiseptic are an amount of, all the other are deionized water (being added to 100 parts).
Concrete technological process is with embodiment ten.
Embodiment 12
The present invention's plant extract of the present invention is used to prepare the water preparation of whitening moisturizing, its prescription is in 100 parts wherein: 6.0 parts of green tea extracts, 1.92 parts of Folium Ginkgo extract, 0.08 part of Herba Centellae extract, 5.0 parts of glycerol, HA0.05 part, 10.0 parts of 1,3 butylene glycols, antiseptic are an amount of, all the other are deionized water (being added to 100 parts).
Concrete technological process is: use 1,3 butylene glycol and part deionized water dissolving green tea extract, Folium Ginkgo extract, Herba Centellae extract earlier, filter stand-by; HA is uniformly dispersed with the part deionized water, and is stand-by; The residue deionized water, glycerol, antiseptic stirs for 75 ℃-80 ℃; Be cooled to 40 ℃, add and filter good green tea extract, Folium Ginkgo extract, Herba Centellae extract and scattered HA, stir evenly, be cooled to room temperature and get final product.
Embodiment 13
Plant extract of the present invention is used to prepare the granule of whitening moisturizing, its prescription is in 100 parts wherein: 24.0 parts of green tea extracts, 6.0 parts of Folium Ginkgo extract, 10.0 parts of Herba Centellae extracts, 30 parts of fatty alcohol-ether sodium sulfates, 60 ℃ of stirrings obtained chocolate brown powder, pH value 5-7 in 90 minutes.
Embodiment 14
Plant extract of the present invention is used to prepare the granule of whitening moisturizing, its prescription is in 100 parts wherein: 1.0 parts of green tea extracts, 10.0 parts of Folium Ginkgo extract, 9.0 parts of Herba Centellae extracts, 80 parts of fatty alcohol-ether sodium sulfates, 60 ℃ of stirrings obtained chocolate brown powder, pH value 5-7 in 90 minutes.
Herba Centellae extract Herba Centellae total glycosides content 10%～95% in the above embodiments one to 14, content is preferably 30%～95%, polyhydroxy phenol kind compound content 5%～95% in the green tea extract, content is preferably 20%～80%, terpenoid and flavonoid content 5%～50% in the Folium Ginkgo extract, content is preferably 10%～45%.
Embodiment 15
Experimental applications:
Plant extract of the present invention is used to prepare the medicine of whitening moisturizing or the clinic trial of cosmetics is observed.
1. clinical data
Select 100 routine healthy womens, be divided into 2 groups at random, experimental group 50 examples, 27.8 years old mean age (25-38 year), matched group 50 examples, 28.5 years old mean age, the cicatrix course of disease 3 months～6 months, average 4 months.All experimenters test local medicine and the treatment of employing additive method of not using whitening moisturizing in preceding 4 weeks.
2. administrated method
Trial drug is packed with unified nothing sign and is carried out blind method processing.Experimental group uses the emulsion that makes by embodiment six to be coated with 4 * 4cm zone, left forearm inboard outward, and right forearm is the check plot; Matched group is coated with 4 * 4cm zone, left forearm inboard with the substrate except that composition of plant extracts among the embodiment six, and right forearm is the check plot.Avoid motion before the each test of experimenter, first cleaner assay position before smearing, again trial drug is applied to the test position respectively, sooner or later each uses once, 1 one months courses of treatment, each trial drug that uses is measured after two hours and after constant temperature and humidity indoor (28 ℃ of temperature, humidity 60%) is had a rest minute.Two groups of experimenters all before use with use once the back, use after back and measuring after 1 week of back of stopping using weekly, the testing time is for being same time in the daytime.Test instrunment is that the skin moisture tester CM825 that produces of German CK company and dermal melanin and haemachrome tester MX18 measure, estimate the whitening skin and preserving moisture effect after on probation respectively.
3. evaluation index: melanin, moisture content of skin.
4. result of the test
In the whitening skin and preserving moisture effect clinical observation test of emulsion of the present invention to skin, two groups of sample standard deviations do not have loss situation, as seen from Table 1, dermal melanin content reduced gradually after test group was used emulsion of the present invention, reach during to 12 weeks minimum (110.5 ± 20.8), the emulsion of the present invention of stopping using begins after 1 week to increase, but still maintain reduced levels (125.8 ± 23.3), and the improvement of matched group dermal melanin content in entire test is more not obvious, melanin content is (155.8 ± 27.2) during 12 weeks, inactive 1 Zhou Shiwei (156.4 ± 28.8), comparing difference has significance between two groups; Moisture content of skin increases gradually, peak during to 12 weeks (89.5 ± 5.8), the emulsion of the present invention of stopping using begins after 1 week to descend, but still maintain higher level (81.9 ± 8.6), and matched group improvement of moisture content of skin in entire test is more not obvious, moisture content of skin is (65.3 ± 10.9) during 12 weeks, 1 Zhou Shiwei (62.8 ± 11.5) that stops using, and comparing difference has significance between two groups.The result sees table 1 for details.
Table 1 emulsion of the present invention is to the clinical treatment observation of whitening moisturizing effect (x ± s)
Annotate: two groups are used front and back self relatively,
*P＜0.05,
*P＞0.05;
The improvement degree compares between two groups,
*P＜0.05
Claims (13)
1. composition of plant extracts, it is characterized in that: said composition comprises green tea extract, Folium Ginkgo extract, the Herba Centellae extract as active ingredient.
2. composition of plant extracts according to claim 1 is characterized in that: the weight ratio of described green tea extract, Folium Ginkgo extract and Herba Centellae extract is 5%～90%: 5%～50%: 5%～45%.
3. composition of plant extracts according to claim 1 is characterized in that: the weight ratio of described green tea extract, Folium Ginkgo extract and Herba Centellae extract is 30%～85%: 10%～40%: 5%～30%.
4. composition of plant extracts according to claim 1 is characterized in that: the weight part ratio of described green tea extract, Folium Ginkgo extract and Herba Centellae extract is 40%～80%: 10%～30%: 10%～30%.
5. composition of plant extracts according to claim 1 is characterized in that: the preferred weight proportioning of described green tea extract, Folium Ginkgo extract and Herba Centellae extract is 80%: 10%: 10%.
6. according to each described composition of plant extracts of claim 1 to 5, it is characterized in that: polyhydroxy phenol kind compound content 5%～95% in the described green tea extract, content is preferably 20%～80%.
7. according to each described composition of plant extracts of claim 1 to 5, it is characterized in that: terpenoid and flavonoid content 5%～50% in the described Folium Ginkgo extract, content is preferably 10%～45%.
8. according to each described composition of plant extracts of claim 1 to 5, it is characterized in that: Herba Centellae total glycosides content 10%～95% in the described Herba Centellae extract, content is preferably 30%～95%.
9. according to each described composition of plant extracts of claim 1 to 5, it is characterized in that: Herba Centellae total glycosides content 10%～95% in the described Herba Centellae extract, content is preferably 30%～95%, polyhydroxy phenol kind compound content 5%～95% in the green tea extract, content is preferably 20%～80%, terpenoid and flavonoid content 5%～50% in the Folium Ginkgo extract, content is preferably 10%～45%.
10. the preparation method that is used for the whitening skin and preserving moisture cosmetics according to each described composition of plant extracts of claim 1 to 5, it is characterized in that: with each component or the above-mentioned composition of plant extracts and the medically acceptable inert matter or the carrier mixing of above-mentioned composition of plant extracts, the acquisition form is gel, cream frost, serosity, water preparation, emulsion or solid goods.
11. composition of plant extracts according to claim 9 is used for the preparation method of whitening skin and preserving moisture cosmetics, it is characterized in that: with each component or the above-mentioned composition of plant extracts and the medically acceptable inert matter or the carrier mixing of above-mentioned composition of plant extracts, the acquisition form is gel, cream frost, serosity, water preparation, emulsion or solid goods.
12. be used to prepare the cosmetics of whitening skin and preserving moisture according to each described composition of plant extracts of claim 1 to 5, it is characterized in that: the content of described composition of plant extracts in final products is 0.5%～20%.
13. be used to prepare the cosmetics of whitening skin and preserving moisture according to each described composition of plant extracts of claim 1 to 5, it is characterized in that: the content of described composition of plant extracts in final products is 10%～20%.
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| CN103796631A (en) * | 2012-06-29 | 2014-05-14 | 生物光谱公司 | Compositions for whitening skin comprising madecassoside |
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| CN104523536A (en) * | 2015-01-24 | 2015-04-22 | 黄荣波 | Whitening and moisturizing cosmetic containing Asiatic pennywort herb extract and preparation method of whitening and moisturizing cosmetic |
| CN105534831B (en) * | 2016-03-17 | 2019-04-05 | 易智彪 | A kind of dendrobium candidum leaf extract with moisture-keeping efficacy and its in the application prepared in skin care item |
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| CN106727141A (en) * | 2016-12-28 | 2017-05-31 | 广州市聚吉科绿色化学共性技术研究院有限公司 | A kind of plant composition and its application with white-skinned face function |
| CN106726985A (en) * | 2016-12-28 | 2017-05-31 | 广州市聚吉科绿色化学共性技术研究院有限公司 | A kind of skin whitening, moisturizing plant composition and its application |
| CN107951830A (en) * | 2017-12-07 | 2018-04-24 | 广州赛莱拉干细胞科技股份有限公司 | Rosemary stem cell extract antioxidant composition and the skin care item containing said composition |
| CN112386552A (en) * | 2020-12-08 | 2021-02-23 | 广州名妆化妆品制造有限公司 | Preparation method of compound freckle-removing and whitening composition |
| CN113980098A (en) * | 2021-12-27 | 2022-01-28 | 浙江湃肽生物有限公司深圳分公司 | Nonapeptide-1 derivative and synthesis method and application thereof |
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