CN107929721A - 一种具有促进青少年骨骼生长和增高功效的配方产品 - Google Patents
一种具有促进青少年骨骼生长和增高功效的配方产品 Download PDFInfo
- Publication number
- CN107929721A CN107929721A CN201711172423.1A CN201711172423A CN107929721A CN 107929721 A CN107929721 A CN 107929721A CN 201711172423 A CN201711172423 A CN 201711172423A CN 107929721 A CN107929721 A CN 107929721A
- Authority
- CN
- China
- Prior art keywords
- calcium
- collagen
- parts
- formulation product
- bone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 62
- 238000009472 formulation Methods 0.000 title claims abstract description 48
- 230000008468 bone growth Effects 0.000 title claims abstract description 33
- 230000000694 effects Effects 0.000 title claims abstract description 27
- 102000008186 Collagen Human genes 0.000 claims abstract description 59
- 108010035532 Collagen Proteins 0.000 claims abstract description 59
- 229920001436 collagen Polymers 0.000 claims abstract description 59
- RQFQJYYMBWVMQG-IXDPLRRUSA-N chitotriose Chemical compound O[C@@H]1[C@@H](N)[C@H](O)O[C@H](CO)[C@H]1O[C@H]1[C@H](N)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)[C@@H](CO)O1 RQFQJYYMBWVMQG-IXDPLRRUSA-N 0.000 claims abstract description 30
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 29
- 229930003316 Vitamin D Natural products 0.000 claims abstract description 28
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims abstract description 28
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 claims abstract description 28
- 239000001354 calcium citrate Substances 0.000 claims abstract description 28
- 235000013337 tricalcium citrate Nutrition 0.000 claims abstract description 28
- 239000011710 vitamin D Substances 0.000 claims abstract description 28
- 235000019166 vitamin D Nutrition 0.000 claims abstract description 28
- 150000003710 vitamin D derivatives Chemical class 0.000 claims abstract description 28
- 229940046008 vitamin d Drugs 0.000 claims abstract description 28
- 229960004256 calcium citrate Drugs 0.000 claims description 27
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims description 19
- 229910001424 calcium ion Inorganic materials 0.000 claims description 19
- 210000000845 cartilage Anatomy 0.000 claims description 18
- 235000013305 food Nutrition 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 9
- 150000001875 compounds Chemical class 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 7
- 241000251468 Actinopterygii Species 0.000 claims description 6
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 6
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 6
- 239000002775 capsule Substances 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 6
- 239000003826 tablet Substances 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 5
- 241001465754 Metazoa Species 0.000 claims description 4
- 229940092124 calcium citrate malate Drugs 0.000 claims description 4
- MPCMQXRREZMSPJ-UHFFFAOYSA-L calcium;2-hydroxybutanedioate;2-hydroxypropane-1,2,3-tricarboxylic acid;pentahydrate Chemical compound O.O.O.O.O.[Ca+2].[O-]C(=O)C(O)CC([O-])=O.OC(=O)CC(O)(C(O)=O)CC(O)=O MPCMQXRREZMSPJ-UHFFFAOYSA-L 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 235000013601 eggs Nutrition 0.000 claims description 4
- 239000003292 glue Substances 0.000 claims description 4
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 3
- 239000001736 Calcium glycerylphosphate Substances 0.000 claims description 3
- 229920002307 Dextran Polymers 0.000 claims description 3
- 241000287828 Gallus gallus Species 0.000 claims description 3
- 244000017020 Ipomoea batatas Species 0.000 claims description 3
- 235000002678 Ipomoea batatas Nutrition 0.000 claims description 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 3
- 235000008429 bread Nutrition 0.000 claims description 3
- 239000011692 calcium ascorbate Substances 0.000 claims description 3
- 235000010376 calcium ascorbate Nutrition 0.000 claims description 3
- 229940047036 calcium ascorbate Drugs 0.000 claims description 3
- YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 claims description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 3
- 229960003563 calcium carbonate Drugs 0.000 claims description 3
- 108010033929 calcium caseinate Proteins 0.000 claims description 3
- 239000001110 calcium chloride Substances 0.000 claims description 3
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 3
- 229960002713 calcium chloride Drugs 0.000 claims description 3
- 229940062672 calcium dihydrogen phosphate Drugs 0.000 claims description 3
- 239000004227 calcium gluconate Substances 0.000 claims description 3
- 229960004494 calcium gluconate Drugs 0.000 claims description 3
- 235000013927 calcium gluconate Nutrition 0.000 claims description 3
- 229940095618 calcium glycerophosphate Drugs 0.000 claims description 3
- UHHRFSOMMCWGSO-UHFFFAOYSA-L calcium glycerophosphate Chemical compound [Ca+2].OCC(CO)OP([O-])([O-])=O UHHRFSOMMCWGSO-UHFFFAOYSA-L 0.000 claims description 3
- 235000019299 calcium glycerylphosphate Nutrition 0.000 claims description 3
- 239000001506 calcium phosphate Substances 0.000 claims description 3
- 229960001714 calcium phosphate Drugs 0.000 claims description 3
- 235000011010 calcium phosphates Nutrition 0.000 claims description 3
- 229940095672 calcium sulfate Drugs 0.000 claims description 3
- 235000011132 calcium sulphate Nutrition 0.000 claims description 3
- BLORRZQTHNGFTI-ZZMNMWMASA-L calcium-L-ascorbate Chemical compound [Ca+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] BLORRZQTHNGFTI-ZZMNMWMASA-L 0.000 claims description 3
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims description 3
- 238000004040 coloring Methods 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 235000003599 food sweetener Nutrition 0.000 claims description 3
- 235000012054 meals Nutrition 0.000 claims description 3
- 235000019691 monocalcium phosphate Nutrition 0.000 claims description 3
- 210000003205 muscle Anatomy 0.000 claims description 3
- 235000012149 noodles Nutrition 0.000 claims description 3
- 239000000243 solution Substances 0.000 claims description 3
- 239000003381 stabilizer Substances 0.000 claims description 3
- 239000000725 suspension Substances 0.000 claims description 3
- 239000003765 sweetening agent Substances 0.000 claims description 3
- 210000002435 tendon Anatomy 0.000 claims description 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 3
- 102000001187 Collagen Type III Human genes 0.000 claims description 2
- 108010069502 Collagen Type III Proteins 0.000 claims description 2
- 102000002734 Collagen Type VI Human genes 0.000 claims description 2
- 108010043741 Collagen Type VI Proteins 0.000 claims description 2
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 claims description 2
- 239000001639 calcium acetate Substances 0.000 claims description 2
- 229960005147 calcium acetate Drugs 0.000 claims description 2
- 235000011092 calcium acetate Nutrition 0.000 claims description 2
- 235000010216 calcium carbonate Nutrition 0.000 claims description 2
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 2
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims description 2
- 239000001527 calcium lactate Substances 0.000 claims description 2
- 229960002401 calcium lactate Drugs 0.000 claims description 2
- 235000011086 calcium lactate Nutrition 0.000 claims description 2
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 235000011430 Malus pumila Nutrition 0.000 claims 1
- 235000015103 Malus silvestris Nutrition 0.000 claims 1
- 230000012010 growth Effects 0.000 abstract description 41
- 230000001965 increasing effect Effects 0.000 abstract description 9
- 239000002994 raw material Substances 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000047 product Substances 0.000 description 36
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 22
- 229960005069 calcium Drugs 0.000 description 22
- 239000011575 calcium Substances 0.000 description 22
- 229910052791 calcium Inorganic materials 0.000 description 22
- 235000005911 diet Nutrition 0.000 description 10
- 230000037213 diet Effects 0.000 description 10
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- 210000004349 growth plate Anatomy 0.000 description 9
- 238000011161 development Methods 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 230000035764 nutrition Effects 0.000 description 7
- 235000016709 nutrition Nutrition 0.000 description 7
- 238000010521 absorption reaction Methods 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 5
- 230000018109 developmental process Effects 0.000 description 5
- 230000005611 electricity Effects 0.000 description 5
- 210000003321 cartilage cell Anatomy 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 244000025254 Cannabis sativa Species 0.000 description 3
- 239000005416 organic matter Substances 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 102000003886 Glycoproteins Human genes 0.000 description 2
- 108090000288 Glycoproteins Proteins 0.000 description 2
- 229920002683 Glycosaminoglycan Polymers 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
- 230000014461 bone development Effects 0.000 description 2
- 230000037118 bone strength Effects 0.000 description 2
- 230000002308 calcification Effects 0.000 description 2
- 239000001362 calcium malate Substances 0.000 description 2
- OLOZVPHKXALCRI-UHFFFAOYSA-L calcium malate Chemical compound [Ca+2].[O-]C(=O)C(O)CC([O-])=O OLOZVPHKXALCRI-UHFFFAOYSA-L 0.000 description 2
- 229940016114 calcium malate Drugs 0.000 description 2
- 235000011038 calcium malates Nutrition 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- -1 inorganic acid salt Chemical class 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 239000011574 phosphorus Substances 0.000 description 2
- 229910052698 phosphorus Inorganic materials 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- ODIGIKRIUKFKHP-UHFFFAOYSA-N (n-propan-2-yloxycarbonylanilino) acetate Chemical compound CC(C)OC(=O)N(OC(C)=O)C1=CC=CC=C1 ODIGIKRIUKFKHP-UHFFFAOYSA-N 0.000 description 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- 201000004569 Blindness Diseases 0.000 description 1
- 206010007027 Calculus urinary Diseases 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 102000016611 Proteoglycans Human genes 0.000 description 1
- 108010067787 Proteoglycans Proteins 0.000 description 1
- 208000009911 Urinary Calculi Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 210000001188 articular cartilage Anatomy 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 235000015895 biscuits Nutrition 0.000 description 1
- 230000037182 bone density Effects 0.000 description 1
- 235000001465 calcium Nutrition 0.000 description 1
- 230000003913 calcium metabolism Effects 0.000 description 1
- SMHNUIFHMAGAFL-UHFFFAOYSA-N calcium;2-hydroxypropanoic acid Chemical compound [Ca].CC(O)C(O)=O SMHNUIFHMAGAFL-UHFFFAOYSA-N 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 230000027119 gastric acid secretion Effects 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 230000012447 hatching Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000000366 juvenile effect Effects 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000003050 macronutrient Effects 0.000 description 1
- 235000021073 macronutrients Nutrition 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000036630 mental development Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000002366 mineral element Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 235000021590 normal diet Nutrition 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Substances OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 1
- 229960004838 phosphoric acid Drugs 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 238000012418 validation experiment Methods 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
- A23G3/368—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing vitamins, antibiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/42—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/44—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L7/00—Cereal-derived products; Malt products; Preparation or treatment thereof
- A23L7/10—Cereal-derived products
- A23L7/109—Types of pasta, e.g. macaroni or noodles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
- A61K38/014—Hydrolysed proteins; Derivatives thereof from animals from connective tissue peptides, e.g. gelatin, collagen
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Inorganic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本发明提供了一种具有促进青少年骨骼生产增高功效的配方产品，其主要由下列重量份的原料所构成：胶原蛋白1‑50份；柠檬酸钙1‑30份；维生素D 0.1‑0.5份；壳寡糖0.1‑5份。本发明通过各原料组分科学配伍，实现提高骨骼的生长速度、延长骨骼的生长时间，达到促进青少年骨骼生长、增高的目的。
Description
技术领域
本发明涉及一种配方组合物，特别涉及一种具有促进青少年骨骼生长和增高功效的配方产品，尤其涉及一种以胶原蛋白、钙离子源(例如，柠檬酸钙)、维生素D和壳寡糖为原料制备的配方产品。
背景技术
身高状况是判断青少年身体发育健康与否的一个重要指标。骨骼正常发育和生长是身高的主要原因，儿童、青少年时期是骨骼发育的决定阶段，这个时期的骨骼发育直接决定了身高。不同个体的身高高矮会有一定差异，但是正常的生长和身高对青少年的生理和心理发展都有着非常重要的影响。如何才能保证健康、安全的长高，已成为一个受大众普遍关心的问题。
影响骨骼生长发育、人体身高的主要因素可以分为遗传和营养两个方面。遗传因素很大程度上影响着生长的潜力，而后天的营养作用对骨骼生长发育的速度和时间长度也起着极大的作用。骨骼的生长和青少年的长高有一定的生理周期性，如何延长青少年骨骼生长周期时间及在有限的生长周期内加速骨骼生长的速度是促进青少年骨骼生长、增高的主要途径和机会。
骨骼的组成分为有机质和无机质两大部分：有机质主要是胶原蛋白，无机质主要是钙、磷等矿物盐。要保持生长发育期骨骼的生长、增高的关键和重点，是充分提供胶原蛋白、钙元素的营养摄入、吸收和转化。
生长板是人体骨骼纵向生长的生长机构，细胞活性和营养决定生长板的生长速度和生长时间。青少年从16-23岁之间生长板随时都有可能发生闭合，停止长高。生长板所需的营养主要是Ⅱ型胶原蛋白，Ⅱ型胶原蛋白的负电营养特性促进软骨细胞的增殖、分化和生长，为骨生长提供必需的营养；促进和刺激生长板细胞活跃，加快生长板的形成和储备，在生长板闭合前及时补充Ⅱ型胶原蛋白营养，可延长青少年的生长时间，加快生长速度。
目前促进青少年骨骼生长的方法，主要是补充钙源等矿物元素，但是盲目的补钙，会破坏人体骨骼组织的平衡，加速生长板的钙化，使生长板提前闭合而失去生长功能，使青少年彻底失去长高的机会，造成永久的遗憾。
发明内容
本发明人经过长期研究发现，本发明从青少年的骨骼生长特性及Ⅱ型胶原蛋白的负电特性、细胞孵化特性，促进和刺激生长板软骨细胞的活跃，促进软骨细胞的增殖、分化和生长，加快生长板的形成和储备、延迟生长板的闭合时间，在钙离子源(例如，柠檬酸钙)、维生素D及壳寡糖的配合协同作用下，能够延长青少年骨骼的生长时间、加快骨骼生长速度，达到促进骨骼生长、增高的目的。
因此，本发明提供以下各项：
1.一种具有促进青少年骨骼生长增高功效的配方产品，其中所述配方产品按重量份计包含以下各项或由以下各项组成：胶原蛋白1-50份；钙离子源1-20份；维生素D 0.1-0.5份；和壳寡糖0.1-5份。优选上述重量份是干重重量份。术语“干重”在本文中意思是含水量低于5％(wt)，优选低于4％、3％、2％、1％、0.5％、0.2％或0.1％。
2.根据以上1所述的配方产品，其中所述配方产品按重量份计包含以下各项或由以下各项组成：胶原蛋白15-40份；钙离子源5-15份；维生素D 0.2-0.4份；和壳寡糖1-4份。
3.根据以上1或2所述的配方产品，其中所述胶原蛋白为I型胶原蛋白、II型胶原蛋白、III型胶原蛋白或它们的混合物，和/或来源于生物软骨(如鸡软骨、鱼软骨、牛软骨、猪软骨及其它生物软骨)、鱼鳞、动物皮肤(如鱼皮、猪皮、牛皮及其它生物皮肤)、生物肌腱组织、骨骼提取制得的胶原、复合骨胶原蛋白、骨胶原蛋白、骨胶原蛋白肽、胶原蛋白肽、I型胶原蛋白或它们的组合。
4.根据权利要求1至3中任一项所述的配方产品，其中所述钙离子源选自由以下组成的组：柠檬酸钙、醋酸钙、碳酸钙、酪蛋白钙、氯化钙、柠檬酸苹果酸钙、葡萄糖酸钙、乳酸钙、苹果酸钙、磷酸氢钙、磷酸二氢钙、磷酸钙、硫酸钙、抗坏血酸钙、甘油磷酸钙或它们的组合，优选为柠檬酸钙。
5.根据以上1至4中任一项所述的配方产品，其中所述配方产品按重量份计还包含1-50份的DHA藻油、紫薯粉、酵母β-葡聚糖或它们的组合。优选上述重量份是干重重量份。
6.根据以上1至5中任一项所述的配方产品，其还包含一种或多种甜味剂、调味剂、稳定剂和/或着色剂。
7.根据以上1至6中任一项所述的配方产品，其可被配制为粉末、颗粒、溶液、混悬液、片剂、或胶囊的药物制剂形式或被配制成面包、软或硬糖果、特殊医学用途配方食品、饼干、面条或代餐产品的食品形式。
8.一种制备根据以上1至7中任一项所述的配方产品的方法，所述方法包括：将胶原蛋白、钙离子源、维生素D、壳寡糖混合制成所述配方产品(例如，食品、营养品和药品)。
具体实施方式
根据本发明的一个方面，提供了一种具有促进青少年骨骼生长和增高功效的配方产品，其中所述含有胶原蛋白、钙离子源(例如，柠檬酸钙)、维生素D、壳寡糖。
胶原蛋白(优选含有负电分子粘多糖的Ⅱ型胶原蛋白)
胶原蛋白是一种生物高分子，是动物结缔组织中的主要成分，也是哺乳动物体内含量最多、分布最广的功能性蛋白，占蛋白质总量的25％～30％，某些生物体甚至高达80％以上。骨骼中的有机质70％-80％是胶原蛋白，是构成骨骼网状结构的物质基础，能够起到促进骨骼的形成、维持骨骼的韧性、提高骨骼强度等作用。
研究表明，胶原蛋白的流失和缺乏是造成补钙吸收效果不理想的重要原因，使补钙难以达到最科学、有效的状态。当人体缺乏胶原蛋白时，补充的钙质不易固定，使得骨钙质流失、骨生长缓慢。只有当人体内的胶原蛋白充实有效的时候，骨骼的生长和修复才能从根本上得到改善和解决。胶原蛋白的种类较多，常见类型为I型、II型、III型、V型和XI型。在本发明中，优选含有负电分子粘多糖的II型胶原蛋白。II型胶原蛋白又称为复合骨胶原，是一种含有二十多种营养物质的混合物，其包含的每一种物质的分子量都是不相同的，除了含有糖蛋白和氨基酸分子外，还含有蛋白多糖等大分子。一般在复合骨胶原中，糖蛋白、氨基酸类的分子量小于3000道尔顿，硫酸软骨素的分子量在20000-50000道尔顿，透明质酸的分子量在200000-2200000道尔顿。不同分子量的物质，被人体不同的组织和器官吸收利用。大分子营养物质，优先被关节、腰椎等组织细胞选择性合成利用；中分子营养物质，被骨骼、韧带、心血管、皮肤等组织细胞选择性合成利用；小分子营养物质：被内脏，如肝、肾、肌肉等组织细胞选择性合同利用。本发明的胶原蛋白可以来源于生物软骨(如鸡软骨、鱼软骨、牛软骨、猪软骨及其它生物软骨)、鱼鳞、动物皮肤(如鱼皮、猪皮、牛皮及其它生物皮肤)、生物肌腱组织、骨骼提取制得的胶原、复合骨胶原、骨胶原、骨胶原蛋白、骨胶原蛋白肽、胶原蛋白肽或它们的组合。
钙离子源
钙离子源优选可溶性钙源，包括无机钙源和有机钙源。在本发明的一个优选实施方案中，钙离子源为钙的有机酸盐或无机酸盐，并且可选自由以下组成的组：柠檬酸钙、醋酸钙、碳酸钙、酪蛋白钙、氯化钙、柠檬酸苹果酸钙、葡萄糖酸钙、乳酸钙、苹果酸钙、磷酸氢钙、磷酸二氢钙、磷酸钙、硫酸钙、抗坏血酸钙、甘油磷酸钙或它们的组合，优选为柠檬酸钙。柠檬酸钙属于有机钙源的一种，与无机钙源相比生物利用率高，钙质吸收好，对肾、尿结石的影响很小；柠檬酸钙中钙质的吸收与胃酸水平无关，不会引起胃酸分泌水平较低的人出现肠胃道反应。添加柠檬酸钙以保持骨骼在生长中钙的来源充足，而且柠檬酸钙可以促进人体对锌的吸收。
维生素D
维生素D是钙代谢重要的生物调节因子，能够促进人体对钙、磷的吸收，促进骨矿物质的沉积和钙化作用。
壳寡糖
壳寡糖为带正电荷的碱性寡糖，研究表明，其对提高骨密度、增加骨骼强度和促进骨折的愈合等都有良好的效果。壳寡糖具有一定的排除重金属的功效，能够加强钙的吸收和利用；而且能够降低关节腔中过氧化物的水平，为软骨细胞的生长提供良好的营养环境，促进关节软骨的生长。
对于本发明用于促进青少年骨骼生长和增高功效的配方产品中各组分的配比，没有特别限制。在本发明的一个优选实施方案中，所述配方产品按重量份计包含以下各项或由以下各项组成：胶原蛋白1-50份(例如，10份、25份、40份)；钙离子源(例如，柠檬酸钙)1-30份(例如，8份、12份、15份)；维生素D0.1-0.5份(例如，0.2份、0.3份、0.4份)；壳寡糖0.1-5份(例如1份、3份、5份)。在本发明的另一个优选实施方案中，所述配方产品按重量份计包含以下各项或由以下各项组成：胶原蛋白15-25份；钙离子源(例如，柠檬酸钙)5-15份；维生素D 0.2-0.4份；壳寡糖2-4份。
在本发明的另一个优选实施方案中，本发明用于促进青少年骨骼生长和增高功效的配方产品是仅由胶原蛋白、钙离子源(例如，柠檬酸钙)、维生素D、壳寡糖组成，并且不包含其他(活性)物质，优选所述配方产品按重量份计由以下组成：胶原蛋白1-50份；钙离子源(例如，柠檬酸钙)1-20份；维生素D 0.1-0.5份；壳寡糖0.1-5份。
在本发明的另一个实施方案中，所述配方产品还包含另外的促进骨骼生长的成分。在一个优选实施方案中，所述配方产品按重量份计还可包含1-50份的DHA藻油、紫薯粉、酵母β-葡聚糖或它们的组合。
在本发明的另一个实施方案中，所述配方产品还包含一种或多种药物或食物上可接受的辅剂，例如甜味剂、调味剂、稳定剂和/或着色剂。
本发明的配方产品可以被配制为粉末、颗粒、溶液、混悬液、片剂、胶囊的药物制剂形式或被配制成面包、软或硬糖果、特殊医学用途食品、饼干、面条或代餐产品的食品形式。
根据本发明的另一个方面，提供了一种制备上述配方产品(组合物)的方法，所述方法包括：将胶原蛋白、钙离子源(例如，柠檬酸钙)、维生素D、壳寡糖混合制成所述配方制品(例如，食品、营养品和药品)。
因此，本发明提供一种具有促进青少年骨骼生长和增高的复合制剂配方，从青少年的骨骼生长特性和需求去延长骨骼生长时间、加快骨骼生长速度，达到促进骨骼生长、增高的效果。
实施例
下文将参考实施例详细描述本发明，所述实施例仅是意图举例说明本发明，而不是意图限制本发明的范围。本发明的范围由后附的权利要求具体限定。
制备实施例
胶原蛋白(II型胶原蛋白)采购自湖北公安县丽晶生化有限责任公司(批号：20160301)，柠檬酸钙采购自郑州瑞普生物工程有限公司(批号：20161012084)，维生素D采购自厦门金达威生物科技有限公司(批号：20160301)，壳寡糖采购自山东卫康生物医药科技有限公司(批号：RHS161225)。
实施例1：
在该实施例中，本发明的配方产品(组合物)按重量份包括：胶原蛋白10份，柠檬酸钙8份，维生素D 0.2份，壳寡糖1份，进行混合后做成的粉末、颗粒、液体、片剂或胶囊。
实施例2：
在该实施例中，本发明的配方产品(组合物)按重量份包括：胶原蛋白25份，柠檬酸钙12份，维生素D 0.3份，壳寡糖3份，进行混合后做成的粉末、颗粒、液体、片剂或胶囊。
实施例3：
在该实施例中，本发明的配方产品(组合物)按重量份包括：胶原蛋白40份，柠檬酸钙15份，维生素D 0.4份，壳寡糖5份，进行混合后做成的粉末、颗粒、液体、片剂或胶囊。
效果实施例
实施例4：本发明的应用效果统计实验
2016年在中国武汉同济医院进行应用效果统计实验。选取12-13周岁发育期青少年(青少年母亲身高在155～160cm之间，父亲身高在170～175cm之间)210人，测定身高、年生长速度，进行为期连续12个月的饮食干预功效验证实验。实验对象随机分为7组，每组30人，其中1组对照组，6组实验组。对照组饮食不进行任何干预，实验组按不同配方组合物进行饮食干预。
各组编号、服用配方组合物及服用后统计结果见表1，其中实验组2-5组服用单一原料量与实验组6-7组配方组合物中对应组分等重量；胶原蛋白优选为含有负电分子粘多糖的II型胶原蛋白。
表1
经实验统计对比，结果如下：
30人对照组，正常饮食无饮食干预，年生长速度为5.1±2.2厘米/年；
30人单纯服用胶原蛋白，经12个月饮食干预，年生长速度为6.2±1.8厘米/年，与对照组相比，其年生长速度增加1.1厘米/年，表明胶原蛋白对青少年骨骼生长和增高有比较明显的促进效果；
30人单纯服用柠檬酸钙，经12个月饮食干预，年生长速度为5.9±2.2厘米/年，与对照组相比，其年生长速度增加0.8厘米/年，表明柠檬酸钙对青少年骨骼生长和增高有一定的促进效果；
30人单纯服用维生素D，经12个月饮食干预，年生长速度为5.8±2.6厘米/年，与对照组相比，其年生长速度增加0.7厘米/年，表明维生素D对青少年骨骼生长和增高有一定的促进效果；
30人单纯服用壳寡糖，经12个月饮食干预，年生长速度为5.6±1.8厘米/年，与对照组相比，其年生长速度增加0.5厘米/年，表明壳寡糖对青少年骨骼生长和增高有一定的促进效果；
30人服用柠檬酸钙、维生素D、壳寡糖的组合物(按干重重量份计：柠檬酸钙12份，维生素D 0.3份，壳寡糖3份)，经12个月饮食干预，年生长速度为6.9±3.4厘米/年，与对照组相比，其年生长速度增加1.8厘米/年，表明柠檬酸钙、维生素D、壳寡糖的组合物对青少年骨骼生长和增高有比较明显的促进效果；
30人服用本发明促进青少年骨骼生长和增高功效的配方产品(按干重重量份计：胶原蛋白25份，柠檬酸钙12份，维生素D 0.3份，壳寡糖3份)，经12个月饮食干预，年生长速度为11.3±4.8厘米/年，与对照组相比，其年生长速度增加6.2厘米/年，表明本发明配方产品对青少年骨骼生长和增高有很显著的促进效果；
以上试验结果证明，服用胶原蛋白、柠檬酸钙、维生素D、壳寡糖的配方产品，对青少年的骨骼生长、增高有显著的促进效果。从对青少年的年生长速度的增加量来看，服用本发明促进青少年骨骼生长和增高功效的配方产品，对年生长速度的增加量远高于4种单一原料对青少年年生长速度增加量之和，此表明胶原蛋白、柠檬酸钙、维生素D、壳寡糖的组合对促进青少年的骨骼生长、增高有良好的协同作用。
以上所述仅为本发明的较佳实施例，并不用以限制本发明，凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。
Claims (8)
1.一种具有促进青少年骨骼生长和增高功效的配方产品，其中所述配方产品按重量份计包含：胶原蛋白1-50份；钙离子源1-30份；维生素D0.1-0.5份；和壳寡糖0.1-5份。
2.根据权利要求1所述的配方产品，其中所述配方产品按重量份计包含：胶原蛋白15-40份；钙离子源5-15份；维生素D 0.2-0.4份；和壳寡糖1-4份。
3.根据权利要求1或2所述的配方产品，其中所述胶原蛋白为I型胶原蛋白、II型胶原蛋白、III型胶原蛋白或它们的混合物，和/或来源于生物软骨(如鸡软骨、鱼软骨、牛软骨、猪软骨及其它生物软骨)、鱼鳞、动物皮肤(如鱼皮、猪皮、牛皮及其它生物皮肤)、生物肌腱组织、骨骼提取制得的胶原、复合骨胶原、骨胶原、骨胶原蛋白、骨胶原蛋白肽、胶原蛋白肽、I型胶原蛋白或它们的组合。
4.根据权利要求1至3中任一项所述的配方产品，其中所述钙离子源选自由以下组成的组：柠檬酸钙、醋酸钙、碳酸钙、酪蛋白钙、氯化钙、柠檬酸苹果酸钙、葡萄糖酸钙、乳酸钙、苹果酸钙、磷酸氢钙、磷酸二氢钙、磷酸钙、硫酸钙、抗坏血酸钙、甘油磷酸钙或它们的组合，优选为柠檬酸钙。
5.根据权利要求1至4中任一项所述的配方产品，其中所述配方产品按重量份计还可包含1-50份的DHA藻油、紫薯粉、酵母β-葡聚糖或它们的组合。
6.根据权利要求1至5中任一项所述的配方产品，其还包含一种或多种甜味剂、调味剂、稳定剂和/或着色剂。
7.根据权利要求1至6中任一项所述的配方产品，其可被配制为粉末、颗粒、溶液、混悬液、片剂、或胶囊的药物制剂形式或被配制成面包、软或硬糖果、特殊医学用途配方食品、饼干、面条、或代餐产品的食品形式。
8.一种制备根据权利要求1至7中任一项所述的配方产品的方法，所述方法包括：将胶原蛋白、钙离子源、维生素D及壳寡糖混合制成所述配方制品(例如，食品、营养品和药品)。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2017109972661 | 2017-10-20 | ||
| CN201710997266 | 2017-10-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107929721A true CN107929721A (zh) | 2018-04-20 |
Family
ID=61929800
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711172423.1A Pending CN107929721A (zh) | 2017-10-20 | 2017-11-22 | 一种具有促进青少年骨骼生长和增高功效的配方产品 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107929721A (zh) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109090443A (zh) * | 2018-07-05 | 2018-12-28 | 湖北和格复合骨胶原生物科技有限公司 | 一种具有锁钙补钙强骨功能的营养配方产品 |
| CN114617267A (zh) * | 2022-03-22 | 2022-06-14 | 意润健康产业（广州）有限公司 | 一种强化型复合骨肽及其制备方法与应用 |
| CN115399473A (zh) * | 2021-05-27 | 2022-11-29 | 深圳市回春堂健康管理服务有限公司 | 一种增加骨密度的牦牛骨髓高钙蛋白粉组合物及制备方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104256292A (zh) * | 2014-09-02 | 2015-01-07 | 安徽倮倮米业有限公司 | 一种富钙壮骨营养保健米及其制备方法 |
| CN105595327A (zh) * | 2015-12-24 | 2016-05-25 | 北京航天空间医学研究中心 | 一种航天员专用的柠檬酸钙制剂 |
| CN105831784A (zh) * | 2016-04-07 | 2016-08-10 | 中国农业大学 | 一种微囊化壳寡糖及其制备方法和应用 |
| CN106135890A (zh) * | 2015-04-14 | 2016-11-23 | 青岛贝尔特生物科技有限公司 | 一种有助于骨关节健康的营养组合物 |
-
2017
- 2017-11-22 CN CN201711172423.1A patent/CN107929721A/zh active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104256292A (zh) * | 2014-09-02 | 2015-01-07 | 安徽倮倮米业有限公司 | 一种富钙壮骨营养保健米及其制备方法 |
| CN106135890A (zh) * | 2015-04-14 | 2016-11-23 | 青岛贝尔特生物科技有限公司 | 一种有助于骨关节健康的营养组合物 |
| CN105595327A (zh) * | 2015-12-24 | 2016-05-25 | 北京航天空间医学研究中心 | 一种航天员专用的柠檬酸钙制剂 |
| CN105831784A (zh) * | 2016-04-07 | 2016-08-10 | 中国农业大学 | 一种微囊化壳寡糖及其制备方法和应用 |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109090443A (zh) * | 2018-07-05 | 2018-12-28 | 湖北和格复合骨胶原生物科技有限公司 | 一种具有锁钙补钙强骨功能的营养配方产品 |
| CN115399473A (zh) * | 2021-05-27 | 2022-11-29 | 深圳市回春堂健康管理服务有限公司 | 一种增加骨密度的牦牛骨髓高钙蛋白粉组合物及制备方法 |
| CN114617267A (zh) * | 2022-03-22 | 2022-06-14 | 意润健康产业（广州）有限公司 | 一种强化型复合骨肽及其制备方法与应用 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103519009B (zh) | 一种鸽用保健沙 | |
| CN103404921A (zh) | 一种果蔬酵素组合物及其制备方法 | |
| KR101539382B1 (ko) | 장 기능 개선 및 배변 촉진용 식품 조성물 | |
| CN109090443A (zh) | 一种具有锁钙补钙强骨功能的营养配方产品 | |
| CN107929721A (zh) | 一种具有促进青少年骨骼生长和增高功效的配方产品 | |
| CN102228136A (zh) | 一种营养靶向功能鸡蛋生产方法 | |
| CN106666169A (zh) | 一种海藻美毛膏及其制备方法 | |
| CN110151715A (zh) | 一种哺乳期女性适用的钙咀嚼片及其制备方法 | |
| CN107494963B (zh) | 宠物钙膏及其制备方法 | |
| CN104543534A (zh) | 一种富硒鹌鹑蛋饲料添加剂及其制备方法 | |
| CN107821713A (zh) | 胶原蛋白矿物质复合物压片糖果 | |
| CN107616134A (zh) | 一种乌鸡高产的方法 | |
| CN110604218A (zh) | 一种宠物营养膏的配方及制备方法 | |
| CN101690591A (zh) | 牦牛骨髓多肽长骨增高片(粉) | |
| CN108617881A (zh) | 一种富含多种微量元素的蛋鹅养殖用饲料 | |
| CN107594282A (zh) | 一种银耳小分子肽复配的固体饮料及其制备方法 | |
| CN1135935C (zh) | 一种抗衰老保健食品及制作方法 | |
| CN103535543A (zh) | 仔猪成长精饲料 | |
| CN106417619A (zh) | 一种促进骨骼生长和提高免疫力的乳钙粉 | |
| CN104430889A (zh) | 一种中老年羊奶粉配方及其制备方法和应用 | |
| CN101283741B (zh) | 家蚕复合添加剂及其生产方法 | |
| CN104161185A (zh) | 一种畜禽用营养性饲料添加剂及其制备方法和应用 | |
| CN103690564A (zh) | 林蛙高蛋白钙粉在制备抗疲劳保健品或药物中的应用 | |
| CN107136490A (zh) | 一种肽虫草保健品 | |
| CN113100348A (zh) | 一种猫粮及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180420 |
|
| WD01 | Invention patent application deemed withdrawn after publication |