CN107929432A - 一种消痹痛搽剂 - Google Patents
一种消痹痛搽剂 Download PDFInfo
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Abstract
本发明属于中医药领域，具体为一种消痹痛搽剂。所述消痹痛搽剂由下述原料组分制备而成：白酒、雪上一枝蒿、生马钱子、生祖师麻、生川乌、生草乌、乳香、没药、羌活、花椒、威灵仙、透骨草、苏木、红花、冰片、独活、两面针。本发明的消痹痛搽剂按照中医组方和制备原则精心研制，具有针对性强、疗效好、周期短、价格低、无毒副作用的特点。
Description
【技术领域】
本发明涉及中医药领域，具体涉及一种消痹痛搽剂。
【背景技术】
在中医理论中，由于各种致病因素侵袭人体后引起的一切体表化脓感染性疾病，称为炎，类风湿关节炎、骨关炎，膝关节滑膜炎，会产生肿胀积液，这些积液大多是炎症引起的，时间一长，就会有大量的纤维蛋白沉淀下来，使滑膜壁增厚粘连，积液包囊，很难吸收，因此会郁积，从而不通则痛，中医对于祛瘀主要的方法是活血祛瘀，疏通经络，达到消肿止痛的目的。目前，虽然中药祛瘀的药品很多，但是疗效不理想，治疗时间长，治疗后表面看病情已经好转，但过一段时候后容易复发。
【发明内容】
本发明的发明目的在于：针对现有技术的不足，提供一种消痹痛搽剂，所述消痹痛搽剂按照中医组方和制备原则精心研制，具有针对性强、疗效好、周期短、价格低、无毒副作用的特点。
为了实现上述目的，本发明采用的技术方案如下：
一种消痹痛搽剂，由下述原料组分制备而成：白酒、雪上一枝蒿、生马钱子、生祖师麻、生川乌、生草乌、乳香、没药、羌活、花椒、威灵仙、透骨草、苏木、红花、冰片、独活、两面针。
进一步地，由下述原料组分制备而成：40～60度的白酒2000g～3000g、雪上一枝蒿40～60g、生马钱子10～30g、生祖师麻10～30g、生川乌40～60g、生草乌40～60g、乳香10～30g、没药10～30g、羌活20～40g、花椒20～40g、威灵仙20～40g、透骨草40～60g、苏木40～60g、红花10～30g、冰片10～30g、独活20～40g、两面针20～40g。
优选地，由下述原料组分制备而成：50度的白酒2500g、雪上一枝蒿50g、生马钱子20g、生祖师麻20g、生川乌50g、生草乌50g、乳香20g、没药20g、羌活30g、花椒30g、威灵仙30g、透骨草50g、苏木50g、红花15g、冰片20g、独活30g、两面针30g。
一种制备本发明所述的消痹痛搽剂的方法，包括如下步骤：
(1)按重量份比例分别称取原料：雪上一枝蒿、生马钱子、生祖师麻、生川乌、生草乌、乳香、没药、羌活、花椒、威灵仙、透骨草、苏木、红花、冰片、独活、两面针；机械粉碎备用；
(2)将步骤(1)所得的产物放置于所述白酒中浸泡1～2个月，过滤，取滤液即得成品。
进一步地，所述滤液中，总黄酮的质量百分比含量为0.07～0.09％。
本发明实施例中，总黄酮的含量测定为：按SN/T 4592-2016标准测定。
本发明还提供了上述消痹痛搽剂在制备治疗痹痛药物中的应用。
本发明应用中，所述痹痛为筋膜炎、颈椎病、腰肌劳损、腰椎间盘突出症、骨关节炎、肩周炎等。
本发明所用的原料如下：
雪上一枝蒿：为毛茛科植物短柄乌头Aconitum brachypodum Diels.、展毛短柄乌头Aconitum brachypodum Diels.var.laxiflorum Fletcher et Lauener、曲毛短柄乌头Aconitum brachypodum var.crispulum W.T.Wang、宣威乌头Aconitum nagarum Stapfvar.lasiandrum W.T.Wang、小白撑Aconitum nagarum Stapf var.heterotrichumFletcher et Lauener、铁棒锤Aconitum pendulum Busch、伏毛铁棒锤Aconitum flavumHand.-Mazz.等多种乌头属植物的块根。
生马钱子：为马钱科植物马钱Strychnosnux-vomicaL.的干燥成熟种子。
生祖师麻：为瑞香科植物黄瑞香Daphne giraldii Nitsche、陕甘瑞香Daphnetangutica Maxim.及凹叶瑞香Daphne retusa Hemsl.的茎皮和根皮。
生川乌：为毛茛科植物卡氏乌头AconitumcarmichaeliDebx.的母根。
生草乌：为毛茛科多年生草本植物乌头(野生种)或北乌头的块根。
乳香：为橄榄科植物乳香树Boswellia carterii Birdw.及同属植物Boswelliabhaurdajiana Birdw.树皮渗出的树脂。
没药：为橄榄科植物地丁树Commiphora myrrha Engl.或哈地丁树Commiphoramolmol Engl.的干燥树脂。
羌活：为伞形科植物羌活的干燥根。
花椒：为芸香科植物青椒Zanthoxylum schinifolium Sieb.et Zucc.或花椒Zanthoxylum bungeanum Maxim.的干燥成熟果皮。
威灵仙：为毛莨科植物威灵仙Clematis chinensis Osbeck、棉团铁线莲Clematishexapetala Pall.或东北铁线莲Clematis manshurica Rupr.的干燥根和根茎。
透骨草：为大戟科地构叶属植物地构叶Speranskia tuberculata(Bunge)Baill.的全草。
苏木：为豆科植物苏木Caesalpinia sappan L.的干燥心材。
红花：为菊科植物红花Carthamus tinctorius L.的干燥花。
冰片：又名片脑、桔片、艾片、龙脑香、梅花冰片、羯布罗香、梅花脑、冰片脑、梅冰等，是由菊科艾纳香茎叶或樟科植物龙脑樟枝叶经水蒸汽蒸馏并重结晶而得。
独活：为伞形科植物重齿毛当归Angelica pubescens Maxim.f.biserrata Shanet Yuan的干燥根。
两面针：为芸香科植物两面针Zanthorμlum nitidum(Roxb.)DC.的干燥根。
综上所述，由于采用了上述技术方案，本发明的有益效果是：
本发明处方配伍严谨考究，经大量临床验证，无毒无副作用，使用时，依据病人现有的病灶为基准，揉搽于患处，药物的有效成分通过毛孔渗透到病灶之处，具有疗程短、疗效快速、治疗彻底、不复发的优点，有效率达96％以上，其制作方法简单，原料易得，且疗效好，见效快，成本低。
【具体实施方式】
实施例1
一种消痹痛搽剂，由下述原料组分制备而成：
50度的白酒2500g、雪上一枝蒿50g、生马钱子20g、生祖师麻20g、生川乌50g、生草乌50g、乳香20g、没药20g、羌活30g、花椒30g、威灵仙30g、透骨草50g、苏木50g、红花15g、冰片20g、独活30g、两面针30g。
一种制备本实施例所述的消痹痛搽剂的方法，包括如下步骤：
(1)按重量份比例分别称取原料：雪上一枝蒿、生马钱子、生祖师麻、生川乌、生草乌、乳香、没药、羌活、花椒、威灵仙、透骨草、苏木、红花、冰片、独活、两面针；机械粉碎备用；
(2)将步骤(1)所得的产物放置于所述白酒中浸泡1个月，过滤，取滤液即得成品，所述滤液中，总黄酮的质量百分比含量为0.08％。
实施例2
一种消痹痛搽剂，由下述原料组分制备而成：40度的白酒2000g、雪上一枝蒿40g、生马钱子10g、生祖师麻10g、生川乌40g、生草乌40g、乳香10g、没药10g、羌活20g、花椒20g、威灵仙20g、透骨草40g、苏木40g、红花10g、冰片10g、独活20g、两面针20g。
一种制备本实施例所述的消痹痛搽剂的方法，包括如下步骤：
(1)按重量份比例分别称取原料：雪上一枝蒿、生马钱子、生祖师麻、生川乌、生草乌、乳香、没药、羌活、花椒、威灵仙、透骨草、苏木、红花、冰片、独活、两面针；机械粉碎备用；
(2)将步骤(1)所得的产物放置于所述白酒中浸泡2个月，过滤，取滤液即得成品，所述滤液中，总黄酮的质量百分比含量为0.07％。
实施例3
一种消痹痛搽剂，由下述原料组分制备而成：60度的白酒3000g、雪上一枝蒿60g、生马钱子30g、生祖师麻30g、生川乌60g、生草乌60g、乳香30g、没药30g、羌活40g、花椒40g、威灵仙40g、透骨草60g、苏木60g、红花30g、冰片30g、独活40g、两面针40g。
一种制备本实施例所述的消痹痛搽剂的方法，包括如下步骤：
(1)按重量份比例分别称取原料：雪上一枝蒿、生马钱子、生祖师麻、生川乌、生草乌、乳香、没药、羌活、花椒、威灵仙、透骨草、苏木、红花、冰片、独活、两面针；机械粉碎备用；
(2)将步骤(1)所得的产物放置于所述白酒中浸泡2个月，过滤，取滤液即得成品，所述滤液中，总黄酮的质量百分比含量为0.09％。
实验例本发明消痹痛搽剂对骨关节炎的疗效
1病例选择标准
1.1诊断标准
1.1.1西医诊断标准
临床表现：①多有链球菌感染病史；②急性期可示多发性及游走性关节酸痛，多发生在大关节，可伴红肿痛或结节或红斑；③慢性期可仅感关节酸痛。
化验检查：①抗“O”在1∶500以上；②或血沉增快；③或抗链激酶超过80单位以上；④或抗透明质酸酶在128单位以上；⑤或“C”反应蛋白阳性。
X线片无骨损害。
1.1.2中医诊断标准(寒湿阻络型)：
发病特点：多与气候变化有关。
临床表现：①主症：关节冷痛沉重；②次症：关节肿胀，麻木重着、屈伸不利，局部畏寒，皮色不红、触之不热，遇寒痛增、得热痛减；③舌脉：舌胖质淡暗苔白腻或白滑，脉弦紧或弦缓。具备①③两项，结合②项中的1-2个症状即可确定诊断。
根据上述标准共收集患者300例，随机分为3个治疗组，每组100例，样本无显著差异。
1.2纳入标准
①符合上述诊断标准者；
②年龄在20-75岁者。
1.3排除标准
1.3.1不符合上述中医诊断标准者。
1.3.2虽符合上述中医辩证标准，但同时具有如下情况之一者：
①年龄在20岁以下，或75岁以上者；
②观察期间使用其他药物，如解热镇痛药，抗风湿药和类似药物；
③凡不符合纳入标准，未按规定用药，无法判断疗效或资料不全等影响疗效和安全性判断者。
2治疗方法
治疗组1-3分别使用实施例1-3的消痹痛搽剂对患者患病关节进行揉搽，每日3次，每次用药量5-10ml，3天为一个疗程，治疗3个疗程。
3疗效判定
(1)近期临床痊愈症状全部消失，功能活动恢复正常，主要参考指标(抗“O”、血沉等)结果正常；
(2)显效全部症状消除或主要症状消除，关节功能基本恢复，能参加正常工作和劳动，主要参考指标结果基本正常；
(3)好转主要症状基本消除，主要关节功能基本恢复或有明显进步，生活不能自理转为生活能够自理。或是去工作和劳动能力转为劳动和工作有所恢复。主要理化指标有所改善；
(4)无效治疗一周各方面均无进步者。
4结果
按照上述疗效判定标准统计各组治疗效果，统计结果及总有效率如表1所示。
表1各组治疗效果及总有效率统计数据
| 组别 | 痊愈 | 显效 | 好转 | 无效 | 总有效率 |
| 治疗组1 | 30 | 56 | 10 | 4 | 96.0％ |
| 治疗组2 | 42 | 48 | 8 | 2 | 98.0％ |
| 治疗组3 | 48 | 39 | 13 | 0 | 100.0％ |
从表1可以看出，实施例1～3对治疗骨关节炎的效果显著，有效率达到96.0％以上；在治疗3个疗程后每周均对患者进行随访，持续半年，并未发现复发的迹象。可见，采用本发明治疗骨关节炎可显著改善局部血液循环，减少淤血，疏通经络，疗效确切，不易复发。
上述说明是针对本发明较佳可行实施例的详细说明，但实施例并非用以限定本发明的专利申请范围，凡本发明所提示的技术精神下所完成的同等变化或修饰变更，均应属于本发明所涵盖专利范围。
Claims (7)
1.一种消痹痛搽剂，其特征在于，由下述原料组分制备而成：白酒、雪上一枝蒿、生马钱子、生祖师麻、生川乌、生草乌、乳香、没药、羌活、花椒、威灵仙、透骨草、苏木、红花、冰片、独活、两面针。
2.根据权利要求1所述的消痹痛搽剂，其特征在于，由下述原料组分制备而成：40～60度的白酒2000g～3000g、雪上一枝蒿40～60g、生马钱子10～30g、生祖师麻10～30g、生川乌40～60g、生草乌40～60g、乳香10～30g、没药10～30g、羌活20～40g、花椒20～40g、威灵仙20～40g、透骨草40～60g、苏木40～60g、红花10～30g、冰片10～30g、独活20～40g、两面针20～40g。
3.根据权利要求2所述的消痹痛搽剂，其特征在于，由下述原料组分制备而成：50度的白酒2500g、雪上一枝蒿50g、生马钱子20g、生祖师麻20g、生川乌50g、生草乌50g、乳香20g、没药20g、羌活30g、花椒30g、威灵仙30g、透骨草50g、苏木50g、红花15g、冰片20g、独活30g、两面针30g。
4.一种制备权利要求1～3任一项所述的消痹痛搽剂的方法，其特征在于，包括如下步骤：
(1)按重量份比例分别称取原料：雪上一枝蒿、生马钱子、生祖师麻、生川乌、生草乌、乳香、没药、羌活、花椒、威灵仙、透骨草、苏木、红花、冰片、独活、两面针；机械粉碎备用；
(2)将步骤(1)所得的产物放置于所述白酒中浸泡1～2个月，过滤，取滤液即得成品。
5.根据权利要求4所述的消痹痛搽剂的制备方法，其特征在于：所述滤液中，总黄酮的质量百分比含量为0.07～0.09％。
6.权利要求1～5任一项所述的消痹痛搽剂在制备治疗痹痛药物中的应用。
7.根据权利要求6所述的消痹痛搽剂在制备治疗痹痛药物中的应用，其特征在于，所述痹痛为筋膜炎、颈椎病、腰肌劳损、腰椎间盘突出症、骨关节炎、肩周炎。
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