CN107927732A - 一种预防抑郁及老年痴呆的保健食品及其制备方法 - Google Patents
一种预防抑郁及老年痴呆的保健食品及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种预防抑郁及老年痴呆的保健食品及其制备方法,所述保健品由以下重量份数的原料组成:茶氨酸80~250份,γ‑氨基丁酸20~250份,神经酸20~100份,磷脂酰丝氨酸80~300份,银杏叶提取物10~100份,亚麻籽粉10~100份,维生素0.015~6份,低聚糖180~450份,5‑羟基色氨酸0.015~50份。其制备方法为粉碎、过筛,按比例称取各组分及辅料,混合均匀后,制备成所需制剂。本发明可以有效预防及缓解抑郁和老年痴呆,并明显促进睡眠,均为天然原料,无任何副作用,对于无法分辨是抑郁还是老年痴呆患者尤为适用。
Description
技术领域
本发明涉及一种预防抑郁及老年痴呆的保健食品及其制备方法,更具体涉及一种含有磷脂酰丝氨酸(PS)和多种功能氨基酸的保健食品。
背景技术
随着人均寿命的延长、社会老龄化的加快、老年性疾病发病率的逐渐增高,老年人抑郁症和老年痴呆会变得更加常见。据世界卫生组织统计,在老年人口中,抑郁症老人约占7%—10%;在患有躯体疾病的老年人中,有一半伴有抑郁症。而世界各地老年人精神疾病调查显示,在老年人群体中,抑郁症是发病率最高的,其次是老年痴呆症。老年痴呆患病率呈上升趋势。随着我国人口老龄化加剧,老年期痴呆患病率总体呈上升趋势。研究结果显示,在65岁及以上人群中,老年期痴呆患病率为5.56%。有些老年抑郁症患者的病情发展到严重阶段时,思维和动作都会受到抑制(尤其是思维抑制),会出现与老年痴呆症相类似的一些临床表现。另外,有一部分老年痴呆症患者在病程的早期也会出现一些抑郁症状,很像患了老年抑郁症,只是到了疾病的中晚期,老年痴呆症的真正面目才会充分表现出来。可见,老年痴呆和抑郁症在老年人中发病率很高,由于老年人的一些特点,导致这两种疾病在症状表现上有不少相似之处,有时会难以区别,以致延误病情。鉴于老年痴呆和抑郁症在老年人中发病率高、且难以分辨的特点,有必要开发一种既能预防老年痴呆又能预防抑郁的保健食品。
失眠是最常见的睡眠障碍,具有很高的发病率。失眠与抑郁症、老年痴呆之间也有密切的联系。大约有70%的抑郁症患者有失眠的症状,而失眠患者中抑郁症的患病率比非失眠患者高3-4倍。也有调查显示,除了一些遗传因素或其他代谢因素之外,失眠等睡眠障碍方面疾病对老年痴呆症,尤其是早期的老年痴呆症有着较为直接的影响作用。失眠的老人患老年痴呆的几率会比正常人要高80%。因此,缓解失眠症状对于预防抑郁及老年痴呆有着重要的作用。因此,开发一种预防抑郁及老年痴呆且具有助眠功效的保健食品显得尤为必要。
长期服用药物易出现头晕、嗜睡、恶心、呕吐等副作用,甚至导致依赖性。因此,研发一种天然、无副作用的、可以预防抑郁、老年痴呆且具有助眠作用的保健食品将成为老年人的福音,并具有广阔的市场前景。
发明内容
本发明的目的在于提供一种具有预防抑郁和老年痴呆并具有助眠作用的保健品及其制备方法。
本发明的技术解决方案是:
一种预防抑郁及老年痴呆的保健食品,其特征是:包含以下重量份数的成分:
茶氨酸 80~250份
γ-氨基丁酸 20~250份
神经酸 20~100份
磷脂酰丝氨酸 80~300份
银杏叶提取物 10~100份
亚麻籽粉 10~100份
维生素 0.015~6份
低聚糖 200~450份
5-羟基色氨酸 0.015~50份。
所述磷脂酰丝氨酸是钠盐的形式。在一定量的范围每剂量50至400毫克,以及姜黄素的存在量之间的范围内50和1000mg每剂量。
低聚糖为低聚果糖、低聚半乳糖等低聚糖的任意一种或几种。维生素为B族维生素、维生素C、维生素E中的一种或几种。
为固体制剂或液体制剂,所述固体制剂为片剂、胶囊剂、粉剂或软胶囊剂;所述液体制剂为口服液。
还包括药学上可接受的辅料;所述药学上可接受的辅料为乳糖、干淀粉、交联羧甲基纤维素钠、羧甲基淀粉钠、硬脂酸镁、二氧化硅、碳酸三钙中的一种或多种。
一种预防抑郁及老年痴呆的保健食品的制备方法,其特征是:按比例称取各组分,过筛,混合均匀后,制备成所需制剂。
磷脂酰丝氨酸大量存在于脑神经细胞中,被称为“脑的营养素”,主要功能是改善神经细胞功能,调节神经脉冲的传导,增进大脑记忆功能。在高龄化社会中,患有人认知障碍症的中老年人不断增加,给社会造成了巨大的压力。磷脂酰丝氨酸具有重要的生理功能,如改善记忆力、延缓脑疲劳,治疗老年痴呆症;治疗儿童多动症;缓解精神压力;治疗抑郁症等。
神经酸,是迄今为止世界上发现的能促进受损神经组织修复、再生的特效物质,是神经细胞特别是大脑细胞、视神经细胞、周围神经生长、再发育和维持的必需“高级营养素”。神经酸人体自身很难生成,只能靠体外摄取来补充。神经酸是大脑神经纤维和神经细胞的核心天然成分。具有参与生物膜有关的多种生理功能,如恢复神经末梢活性,促进神经细胞生长和发育的功能,是大脑神经系统生长发育修复的必须物质来源,对提高脑神经活跃,防止脑神经衰弱有重要作用。 神经酸的缺乏将会引起神经衰弱、脑萎缩,老年痴呆、帕金森综合症、视神经衰退、记忆力减退、失眠健忘等脑疾病。
茶氨酸是茶叶中特有的一种游离氨基酸,具有镇静放松、促进睡眠、抗抑郁、抗肿瘤、提升免疫力等多种生理功能。相关研究证实L-茶氨酸可以促进大脑表面α波(松驰状态)产生,使人体产生舒畅、愉悦的感觉,但L-茶氨酸不会引起睡眠状态时发生的θ波数量的增加,可见L-茶氨酸在使人情绪稳定的同时不使人趋于睡眠。L-茶氨酸除了在休息状态下有一些抗抑郁放松效果外,还可以通过抑制大脑皮层神经兴奋达到抗应激效应,减轻在有负荷压力状态下人体的生理、心理压力。
γ-氨基丁酸是一种天然存在的功能性氨基酸,是中枢神经系统主要的抑制性神经递质,能够纾缓身心压力、放松心情、帮助入睡、提升睡眠品质,改善抑郁症和提高记忆力。并且由于γ-氨基丁酸为谷氨酸的三羧酸循环提供了另外一种途径,所以能有效的改善脑血流通,增加氧的供给,促进脑的代谢功能。
5-羟基色氨酸具有催眠作用。在体内可以借助维生素B6生成神经荷尔蒙的前体5-羟色胺,从而促进睡眠和神经安定。色氨酸能使睡眠的潜伏期缩短,REM/NREM的比率增加。有研究认为,色氨酸对入睡困难与轻度睡眠障碍的人效果最好。这种影响与其增加脑内5-羟色胺含量有关。
低聚糖难以被胃肠消化吸收,甜度低,热量低,基本不增加血糖和血脂。低聚糖类似水溶性植物纤维,能有效降低血清胆固醇、甘油三脂、游离脂肪酸的数量,对于因血脂高而引起的高血压、动脉硬化等一系列心血管疾病有较好的改善作用。进入大肠作为双歧杆菌的增殖因子,能有效地促进人体内双歧杆菌的生长繁殖,抑制腐败菌生长,长期食用可减缓衰老、通便、抑菌、防癌、减轻肝脏负担。
维生素C和维生素E主要以抗氧化或清除自由基的作用在预防老年痴呆方面具有一定作用。
维生素B1,可调节植物神经功能紊乱,降低大脑皮质的兴奋,有助于睡眠。缺乏维生素B1,是造成精神不稳定及失眠的主要原因之一。同时维生素B1对治疗睡眠不足也特别有效。
维生素B6,与糖分一起摄取,可消除因长期睡眠不足而积累的疲劳。将维生素B6与烟酸配合吸收,可使大脑中产生一种所谓血清素的化学物质,使睡眠安稳。
维生素B12,对大脑中枢神经、大脑的功能产生作用,不仅可以改善睡眠,还可以调整生物钟,克制时差困恼。
本发明产品可明显助眠,预防老年痴呆和抑郁,经100多例使用,有效率95%以上。特别添加了磷脂酰丝氨酸、神经酸以及茶氨酸在提高记忆力、预防老年痴呆方面具有协同增效作用的物质,另外添加了氨基丁酸,而茶氨酸和氨基丁酸在助眠、缓解压力和抗抑郁方面又有显著作用。
典型使用例:
例1:李某某,女,53岁,抑郁失眠,整个内心是麻木的,感受不到任何情绪,记忆力下降,思维迟钝,注意力集中不了,脑子里面很多消极想法,很多简单的事情都无法完成。服用本发明保健品,早晚各服一剂量(1粒),连续两个月后,失眠就大有缓解,睡觉起来精神大有好转。连续六个月后,情绪也平稳很多,话也多了一些,偶尔也愿意出门。
例2:吴某某,男,72岁,轻微老年痴呆患者。容易忘事,丢三拉四,刚放置的东西就忘掉所放的位置,刚买下的东西就忘记拿走,有时候做菜时已放过盐过一会儿又放一次,情绪比较低落,对什么事都提不起兴趣。服用本发明保健品,早晚各服一剂量(1粒),连续两个月后,记忆力有所好转,病情得到了有效控制。
下面结合实施例对本发明作进一步说明。
实施例1
本实施例预防抑郁和老年痴呆且助眠的保健食品组合物,含有如下重量份数的成分:
磷脂酰丝氨酸 150份
γ-氨基丁酸 90份
茶氨酸 200份
神经酸 35份
5-羟基色氨酸 3份
亚麻籽粉 15份
银杏叶提取物 4.45份
维生素B1 0.5份
维生素B6 0.35份
维生素C 2.8份
维生素E 1.85份
羧甲基淀粉钠 65份
硬脂酸镁 18份
低聚果糖 180份
制备方法:
(1)过筛:磷脂酰丝氨酸、神经酸、亚麻籽粉、银杏叶提取物、低聚果糖、γ-氨基丁酸、茶氨酸、5-羟基色氨酸、维生素B1、维生素B6、维生素C、维生素E、羧甲基淀粉钠、硬脂酸镁分别过80目筛。
(2)称量:按配方称取筛分过的磷脂酰丝氨酸、神经酸、亚麻籽粉、银杏叶提取物、低聚果糖、γ-氨基丁酸、茶氨酸、牛磺酸、5-羟基色氨酸、亚硒酸钠、碳酸钙、维生素B1、维生素B6、维生素C、维生素E、羧甲基淀粉钠。
(3)混合:将上述物料按等量递加法混合均匀,经摇摆制粒机制成颗粒,在颗粒中加入羧甲基淀粉钠、硬脂酸镁,总混,压片,分装,1g/片。
(4)服用剂量:每天服用1片。
所述银杏叶提取物是市售产品(例:江苏贝斯康药业有限公司产品等)。
实施例2
本实施例降血压助眠的保健食品组合物,含有如下重量份数的成分:
磷脂酰丝氨酸 200份
γ-氨基丁酸 160份
茶氨酸 100份
神经酸 35份
5-羟基色氨酸 45份
亚麻籽粉 35份
银杏叶提取物 80份
维生素B1 0.025份
维生素B6 0.035份
维生素C 4.5份
维生素E 0.8份
羧甲基淀粉钠 45份
硬脂酸镁 14份
低聚半乳糖 120份。
制备方法:
(1)过筛:低聚半乳糖、磷脂酰丝氨酸、神经酸、亚麻籽粉、银杏叶提取物、γ-氨基丁酸、茶氨酸、5-羟基色氨酸、维生素B1、维生素B6、维生素C、维生素E、羧甲基淀粉钠、硬脂酸镁分别过80目筛。
(2)称量:按配方称取筛分过的低聚半乳糖、磷脂酰丝氨酸、神经酸、亚麻籽粉、银杏叶提取物、γ-氨基丁酸、茶氨酸、5-羟基色氨酸、维生素B1、维生素B6、维生素C、维生素E、羧甲基淀粉钠、硬脂酸镁。
(3)混合:将上述物料按等量递加法混合均匀,得混合粉。
(4)填充胶囊:混合粉填充胶囊,600mg/粒。
(5)服用剂量:每天服用2粒。
所述银杏叶提取物是市售产品。
Claims (7)
1.一种预防抑郁及老年痴呆的保健食品,其特征是:包含以下重量份数的成分:
茶氨酸 80~250份
γ-氨基丁酸 20~250份
神经酸 20~100份
磷脂酰丝氨酸 80~300份
银杏叶提取物 10~100份
亚麻籽粉 10~100份
维生素 0.015~6份
低聚糖 180~400份
5-羟基色氨酸 0.015~50份。
2.根据权利要求1所述的预防抑郁及老年痴呆的保健食品,其特征是:所述磷脂酰丝氨酸是钠盐的形式。
3.根据权利要求1所述的预防抑郁及老年痴呆的保健食品,其特征是:低聚糖为低聚果糖、低聚半乳糖等低聚糖的任意一种或几种。
4.根据权利要求1所述的预防抑郁及老年痴呆的保健食品,其特征是:为固体制剂或液体制剂,所述固体制剂为片剂、胶囊剂、粉剂或软胶囊剂;所述液体制剂为口服液。
5.根据权利要求1所述的预防抑郁及老年痴呆的保健食品,其特征是:还包括药学上可接受的辅料;所述药学上可接受的辅料为乳糖、干淀粉、交联羧甲基纤维素钠、羧甲基淀粉钠、硬脂酸镁、二氧化硅、碳酸三钙中的一种或多种。
6.根据权利要求1所述的预防抑郁及老年痴呆的保健食品,其特征是:所述维生素包括维生素B1、维生素B6、维生素C和维生素E。
7.一种权利要求1所述的预防抑郁及老年痴呆的保健食品的制备方法,其特征是:按比例称取各组分,过筛,混合均匀后,制备成所需制剂。
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