CN107922501A - 抗cd40抗体用于治疗狼疮性肾炎的用途 - Google Patents

抗cd40抗体用于治疗狼疮性肾炎的用途 Download PDF

Info

Publication number
CN107922501A
CN107922501A CN201680050230.6A CN201680050230A CN107922501A CN 107922501 A CN107922501 A CN 107922501A CN 201680050230 A CN201680050230 A CN 201680050230A CN 107922501 A CN107922501 A CN 107922501A
Authority
CN
China
Prior art keywords
ser
seq
thr
val
gly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680050230.6A
Other languages
English (en)
Chinese (zh)
Inventor
S·R·布罗德
T·B·弗里曼
G·H·纳波兹尼
M·拉马努詹
P·肖勒
J·施特夫根
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Publication of CN107922501A publication Critical patent/CN107922501A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201680050230.6A 2015-09-01 2016-08-31 抗cd40抗体用于治疗狼疮性肾炎的用途 Pending CN107922501A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562212810P 2015-09-01 2015-09-01
US62/212,810 2015-09-01
US201562257336P 2015-11-19 2015-11-19
US62/257,336 2015-11-19
US201662287587P 2016-01-27 2016-01-27
US62/287,587 2016-01-27
PCT/US2016/049558 WO2017040566A1 (en) 2015-09-01 2016-08-31 Use of anti-cd40 antibodies for treatment of lupus nephritis

Publications (1)

Publication Number Publication Date
CN107922501A true CN107922501A (zh) 2018-04-17

Family

ID=56896810

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680050230.6A Pending CN107922501A (zh) 2015-09-01 2016-08-31 抗cd40抗体用于治疗狼疮性肾炎的用途

Country Status (16)

Country Link
US (3) US20170058038A1 (https=)
EP (1) EP3344655B1 (https=)
JP (2) JP2018529661A (https=)
KR (1) KR20180039172A (https=)
CN (1) CN107922501A (https=)
AU (1) AU2016317028B2 (https=)
BR (1) BR112018001907A2 (https=)
CA (1) CA2993996A1 (https=)
CL (1) CL2018000317A1 (https=)
DK (1) DK3344655T5 (https=)
ES (1) ES2969968T3 (https=)
HU (1) HUE063528T2 (https=)
MX (1) MX390653B (https=)
PH (1) PH12018500445B1 (https=)
PL (1) PL3344655T3 (https=)
WO (1) WO2017040566A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020108621A1 (zh) * 2018-11-30 2020-06-04 江苏恒瑞医药股份有限公司 一种cd40抗体药物组合物及其用途
CN112334195A (zh) * 2018-06-29 2021-02-05 勃林格殷格翰国际有限公司 用于治疗自身免疫性疾病的抗cd40抗体
RU2778572C1 (ru) * 2018-11-30 2022-08-22 Цзянсу Хэнжуй Медисин Ко., Лтд. Фармацевтическая композиция на основе антител к cd40 и ее применение

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2769282C2 (ru) 2016-06-20 2022-03-30 Кимаб Лимитед Анти-PD-L1 и IL-2 цитокины
WO2018119142A1 (en) 2016-12-21 2018-06-28 Amgen Inc. Anti-tnf alpha antibody formulations
US20200299400A1 (en) * 2017-05-25 2020-09-24 Bristol-Myers Squibb Company Antibodies comprising modified heavy constant regions
AU2022214319A1 (en) 2021-01-28 2023-08-03 Regeneron Pharmaceuticals, Inc. Compositions and methods for treating cytokine release syndrome
US20250276092A1 (en) 2024-03-01 2025-09-04 Regeneron Pharmaceuticals, Inc. Methods and compositions for re-dosing aav using anti-cd40 antagonistic antibody to suppress host anti-aav antibody response
WO2025184603A2 (en) 2024-03-01 2025-09-04 Regeneron Pharmaceuticals, Inc. The use of cd40 inhibitors for inhibiting an immune response and enabling immunogen administration and re-administration

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101014386A (zh) * 2004-04-27 2007-08-08 诺华疫苗和诊断公司 拮抗性抗－cd40单克隆抗体及其使用方法
CN101426817A (zh) * 2006-04-21 2009-05-06 诺华有限公司 拮抗性抗-cd4o抗体药物组合物
US20110243932A1 (en) * 2010-03-31 2011-10-06 Boehringer Ingelheim International Gmbh Anti-cd40 antibodies
CN101237882B (zh) * 2005-05-26 2012-08-15 西雅图基因公司 人源化的抗-cd40抗体及其使用方法
CN103635488A (zh) * 2011-04-29 2014-03-12 埃派斯进有限公司 抗-cd40抗体及其使用方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
EP0206448B1 (en) 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hemoglobin combined with a poly(alkylene oxide)
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
EP1400536A1 (en) 1991-06-14 2004-03-24 Genentech Inc. Method for making humanized antibodies
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
AU687755B2 (en) 1992-08-21 1998-03-05 Genentech Inc. Method for treating an LFA-1-mediated disorder
US6037454A (en) 1996-11-27 2000-03-14 Genentech, Inc. Humanized anti-CD11a antibodies
US20030059427A1 (en) * 2000-04-28 2003-03-27 Force Walker R. Isolation and characterization of highly active anti-CD40 antibody
US8277810B2 (en) * 2003-11-04 2012-10-02 Novartis Vaccines & Diagnostics, Inc. Antagonist anti-CD40 antibodies
US20140004131A1 (en) * 2012-05-04 2014-01-02 Novartis Ag Antibody formulation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101014386A (zh) * 2004-04-27 2007-08-08 诺华疫苗和诊断公司 拮抗性抗－cd40单克隆抗体及其使用方法
CN101237882B (zh) * 2005-05-26 2012-08-15 西雅图基因公司 人源化的抗-cd40抗体及其使用方法
CN101426817A (zh) * 2006-04-21 2009-05-06 诺华有限公司 拮抗性抗-cd4o抗体药物组合物
US20110243932A1 (en) * 2010-03-31 2011-10-06 Boehringer Ingelheim International Gmbh Anti-cd40 antibodies
CN102918063A (zh) * 2010-03-31 2013-02-06 贝林格尔.英格海姆国际有限公司 抗-cd40抗体
CN103635488A (zh) * 2011-04-29 2014-03-12 埃派斯进有限公司 抗-cd40抗体及其使用方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
C MOHAN等: ""Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis"", 《J IMMUNOL.》 *
ÈLIA RIPOLL等: ""CD40 gene silencing reduces the progression of experimental lupus nephritis modulating local milieu and systemic mechanisms"", 《PLOS ONE》 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112334195A (zh) * 2018-06-29 2021-02-05 勃林格殷格翰国际有限公司 用于治疗自身免疫性疾病的抗cd40抗体
WO2020108621A1 (zh) * 2018-11-30 2020-06-04 江苏恒瑞医药股份有限公司 一种cd40抗体药物组合物及其用途
CN112839961A (zh) * 2018-11-30 2021-05-25 江苏恒瑞医药股份有限公司 一种cd40抗体药物组合物及其用途
RU2778572C1 (ru) * 2018-11-30 2022-08-22 Цзянсу Хэнжуй Медисин Ко., Лтд. Фармацевтическая композиция на основе антител к cd40 и ее применение
CN112839961B (zh) * 2018-11-30 2023-04-04 江苏恒瑞医药股份有限公司 一种cd40抗体药物组合物及其用途

Also Published As

Publication number Publication date
ES2969968T3 (es) 2024-05-23
US20170058038A1 (en) 2017-03-02
JP2021185169A (ja) 2021-12-09
CA2993996A1 (en) 2017-03-09
EP3344655A1 (en) 2018-07-11
EP3344655B1 (en) 2023-07-26
PH12018500445B1 (en) 2022-08-10
AU2016317028B2 (en) 2021-09-09
MX2018002447A (es) 2018-06-15
HUE063528T2 (hu) 2024-01-28
PL3344655T3 (pl) 2024-02-19
CL2018000317A1 (es) 2018-07-20
AU2016317028A1 (en) 2018-02-22
US20230265203A1 (en) 2023-08-24
DK3344655T5 (da) 2024-10-07
PH12018500445A1 (en) 2018-09-10
MX390653B (es) 2025-03-21
KR20180039172A (ko) 2018-04-17
JP2018529661A (ja) 2018-10-11
US20190177420A1 (en) 2019-06-13
BR112018001907A2 (pt) 2018-09-25
WO2017040566A1 (en) 2017-03-09
DK3344655T3 (da) 2023-10-09

Similar Documents

Publication Publication Date Title
US20230265203A1 (en) Use of anti-cd40 antibodies for treatment of lupus nephritis
KR101760242B1 (ko) 항-ｃｄ40 항체
US8414890B2 (en) Human antibodies to human RANKL, encoding nucleic acids and methods of treatment
JP6289375B2 (ja) 抗ｉｌ−３６ｒ抗体
US20240287198A1 (en) Anti-cd40 antibodies for use in prevention of graft rejection
CN112823167A (zh) 抗-αvβ8抗体和组合物及其用途
CN113150144A (zh) 肿瘤坏死因子样配体1a特异性抗体及其组合物和用途
JP2008529499A (ja) 抗体変異体とその使用
HUE034203T2 (en) Silent fc variants of anti-cd40 antibodies
CN102884081A (zh) 用dll4拮抗剂治疗自身免疫疾病的方法
CN112334195A (zh) 用于治疗自身免疫性疾病的抗cd40抗体
CA3215058A1 (en) Anti-cd122 antibodies and uses thereof
US20240059781A1 (en) Methods of inducing immune tolerance with modified anti-cd154 antibodies
JP7449390B2 (ja) 抗ｅ－セレクチン抗体、組成物および使用の方法
CN117730099A (zh) 抗tmprss6抗体及其用途
US20220127365A1 (en) Anti-cd94 antibodies and methods of use thereof
US20250197505A1 (en) Anti-cd94 antibodies and methods of use thereof
EA039944B1 (ru) Применение антител к cd40 для лечения волчаночного нефрита
CN121443309A (zh) 多发性骨髓瘤的治疗
KR20260013511A (ko) 암 치료를 위한 조합 요법
WO2024077246A1 (en) Formulations for anti-c1q antibodies
CN116782931A (zh) 抗cd40抗体用于治疗炎症性病况的用途
HK40042102A (en) Anti-avb8 antibodies and compositions and uses thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination