CN107921111B - 用于各种癌症免疫治疗的新型肽、肽组合物和支架 - Google Patents

用于各种癌症免疫治疗的新型肽、肽组合物和支架 Download PDF

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CN107921111B
CN107921111B CN201680050119.7A CN201680050119A CN107921111B CN 107921111 B CN107921111 B CN 107921111B CN 201680050119 A CN201680050119 A CN 201680050119A CN 107921111 B CN107921111 B CN 107921111B
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cancer
peptide
cell
cells
tumor
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CN107921111A (zh
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安德烈·马尔
托尼·温斯切尼克
奥利弗·施尔
延斯·弗里切
哈普瑞特·辛格
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Immatics Biotechnologies GmbH
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CN201680050119.7A 2015-08-28 2016-08-26 用于各种癌症免疫治疗的新型肽、肽组合物和支架 Active CN107921111B (zh)

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CN202210818005.XA CN115925806A (zh) 2015-08-28 2016-08-26 用于各种癌症免疫治疗的新型肽、肽组合物和支架
CN201811283191.1A CN109734777B (zh) 2015-08-28 2016-08-26 用于各种癌症免疫治疗的新型肽、肽组合物和支架

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US201562211276P 2015-08-28 2015-08-28
GBGB1515321.6A GB201515321D0 (en) 2015-08-28 2015-08-28 Novel peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers
US62/211,276 2015-08-28
GB1515321.6 2015-08-28
PCT/EP2016/070146 WO2017036936A1 (en) 2015-08-28 2016-08-26 Novel peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers

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CN201811283191.1A Division CN109734777B (zh) 2015-08-28 2016-08-26 用于各种癌症免疫治疗的新型肽、肽组合物和支架

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US (7) US10576132B2 (https=)
EP (2) EP3461494A1 (https=)
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KR (3) KR20180038550A (https=)
CN (1) CN107921111B (https=)
AU (3) AU2016313684B2 (https=)
BR (1) BR112018003460A2 (https=)
CA (2) CA3072922A1 (https=)
CR (6) CR20200493A (https=)
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MA (7) MA43460A1 (https=)
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TW (15) TWI722654B (https=)
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Families Citing this family (31)

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Publication number Priority date Publication date Assignee Title
GB201507030D0 (en) 2015-04-24 2015-06-10 Immatics Biotechnologies Gmbh Immunotherapy against lung cancers, in particular NSCLC
GB201515321D0 (en) * 2015-08-28 2015-10-14 Immatics Biotechnologies Gmbh Novel peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers
ES2970865T3 (es) 2015-12-16 2024-05-31 Gritstone Bio Inc Identificación, fabricación y uso de neoantígenos
JP7075125B2 (ja) 2016-05-25 2022-05-25 イマティクス バイオテクノロジーズ ゲーエムベーハー 標的としてのおよび胆嚢がんおよび胆管がんおよびその他のがんに対する免疫療法で使用するための新規ペプチド、ペプチド組み合わせ
GB201609193D0 (en) 2016-05-25 2016-07-06 Immatics Biotechnologies Gmbh Novel peptides, combination of peptides as targets for use in immunotherapy against gallbladder cancer and cholangiocarcinoma and other cancers
DE102016123893A1 (de) 2016-12-08 2018-06-14 Immatics Biotechnologies Gmbh T-Zellrezeptoren mit verbesserter Bindung
KR102379955B1 (ko) 2016-12-08 2022-03-29 이매틱스 바이오테크놀로지스 게엠베하 짝짓기가 향상된 t 세포 수용체
CN108250286B (zh) * 2016-12-28 2021-06-08 香雪生命科学技术（广东）有限公司 源自于pasd1的肿瘤抗原短肽
EA201992416A1 (ru) 2017-04-10 2020-02-25 Имматикс Байотекнолоджиз Гмбх Пептиды и комбинации пептидов для применения в иммунотерапии лейкозов и других видов рака
SG11201909058WA (en) * 2017-04-10 2019-10-30 Immatics Biotechnologies Gmbh Peptides and combination of peptides for use in immunotherapy against leukemias and other cancers
DE102017115966A1 (de) 2017-07-14 2019-01-17 Immatics Biotechnologies Gmbh Polypeptidmolekül mit verbesserter zweifacher Spezifität
LT3428194T (lt) 2017-07-14 2021-12-10 Immatics Biotechnologies Gmbh Pagerinta dvejopo savitumo polipeptido molekulė
WO2019068007A1 (en) * 2017-09-28 2019-04-04 Immpact-Bio Ltd. UNIVERSAL PLATFORM FOR PREPARING AN INHIBITORY CHIMERIC ANTIGEN RECEPTOR (ICAR)
EP4576103A3 (en) 2017-10-10 2025-08-27 Gritstone bio, Inc. Neoantigen identification using hotspots
CN111630602A (zh) 2017-11-22 2020-09-04 磨石肿瘤生物技术公司 减少新抗原的接合表位呈递
DE102018107224A1 (de) * 2018-02-21 2019-08-22 Immatics Biotechnologies Gmbh Peptide und Kombinationen von Peptiden nicht-kanonischen Ursprungs zur Verwendung in der Immuntherapie gegen verschiedene Krebsarten
TW202016131A (zh) * 2018-05-16 2020-05-01 德商英麥提克生物技術股份有限公司 用於抗癌免疫治療的肽
CN109467596B (zh) * 2018-11-12 2021-11-09 湖北省农业科学院畜牧兽医研究所 转录因子sp1在调控猪rtl1基因表达中的应用
CN109738929B (zh) * 2018-12-03 2022-10-21 中国辐射防护研究院 一种基于居民食物最大消费量的剂量估算方法及系统
TWI858016B (zh) * 2019-02-18 2024-10-11 日商肽夢想股份有限公司 血球凝集素結合肽
JPWO2020230792A1 (https=) * 2019-05-13 2020-11-19
CN110123453B (zh) * 2019-05-31 2021-07-23 东北大学 一种基于无标记增强现实的手术导航系统
WO2021207826A1 (en) * 2020-04-14 2021-10-21 Université de Montréal Novel tumor-specific antigens for acute lymphoblastic leukemia (all) and uses thereof
CN111910000B (zh) * 2020-07-02 2022-07-01 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） 一种预测鼻咽癌预后的肿瘤微环境成分标志物组合及系统
JP2024517630A (ja) * 2021-04-19 2024-04-23 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム Ｍｈｃクラスｉペプチドを含む方法および組成物
US20250073333A1 (en) * 2021-07-19 2025-03-06 Board Of Regents, The University Of Texas System Peptides and engineered t cell receptors targeting fanci, rad51, and pbk antigens and methods of use
CN115607573B (zh) * 2022-12-16 2023-05-23 北京大学第三医院（北京大学第三临床医学院） 一种用于调节杀伤性t细胞活性的方法、药物及其应用
WO2025015234A2 (en) * 2023-07-13 2025-01-16 Ltz Therapeutics Inc. Multispecific antibodies and uses thereof
CN118834328B (zh) * 2024-07-02 2025-09-16 江苏海洋大学 金属蛋白酶9抗原决定基印迹纳米颗粒的制备方法及应用
CN120183512B (zh) * 2025-05-23 2025-08-12 浙江省肿瘤医院 基于转录组测序构建的用于诊断早期宫颈癌淋巴结转移的方法、模型
CN120908452B (zh) * 2025-09-28 2025-12-02 吉林大学 一种用于卵巢癌初步筛查的试剂盒及其应用

Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999045954A1 (en) * 1998-03-13 1999-09-16 Epimmune, Inc. Hla-binding peptides and their uses
EP1104808A1 (en) * 1999-08-05 2001-06-06 Genset ESTs and encoded human proteins
EP1125947A1 (en) * 1998-10-30 2001-08-22 Japan Science and Technology Corporation HUMAN H37 PROTEINS AND cDNAS ENCODING THE SAME
WO2003016523A1 (en) * 2001-08-21 2003-02-27 Millennium Pharmaceuticals, Inc. Screen for cdc7 inhibitors
WO2004099243A2 (en) * 2003-05-05 2004-11-18 Pharmacia Italia S.P.A. Truncated forms of human dbf4, complexes with their interacting partners and methods for identification of inhibitors thereof
WO2005073374A1 (ja) * 2004-01-29 2005-08-11 Dainippon Sumitomo Pharma Co., Ltd. 新規腫瘍抗原蛋白質及びその利用
WO2009015842A2 (en) * 2007-07-27 2009-02-05 Immatics Biotechnologies Gmbh Novel immunogenic epitopes for immunotherapy
WO2010037395A2 (en) * 2008-10-01 2010-04-08 Dako Denmark A/S Mhc multimers in cancer vaccines and immune monitoring
US20110200626A1 (en) * 2008-06-11 2011-08-18 Oncotherapy Science, Inc. Iqgap3 epitope peptides and vaccines containing the same
US20110229504A1 (en) * 2010-03-19 2011-09-22 Immatics Biotechnologies Gmbh Novel immunotherapy against several tumors including gastrointestinal and gastric cancer
WO2014026277A1 (en) * 2012-08-15 2014-02-20 Université de Montréal Method for identifying novel minor histocompatibility antigens
WO2014043441A1 (en) * 2012-09-14 2014-03-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T cell receptors recognizing mhc class ii-restricted mage-a3
CN103911358A (zh) * 2007-07-27 2014-07-09 伊玛提克斯生物技术有限公司 神经元和脑肿瘤的新型免疫疗法
CN104017067A (zh) * 2009-07-03 2014-09-03 英美偌科有限公司 T细胞受体
WO2015018805A1 (en) * 2013-08-05 2015-02-12 Immatics Biotechnologies Gmbh Novel immunotherapy against several tumors, such as lung cancer, including nsclc
WO2015092710A1 (en) * 2013-12-19 2015-06-25 Glaxosmithkline Biologicals, S.A. Contralateral co-administration of vaccines

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2221274A1 (en) * 1995-06-05 1996-12-12 Daniel R. Soppet Human g-protein receptor hgber32
US7342108B2 (en) * 1998-06-25 2008-03-11 The General Hospital Corporation De novo DNA cytosine methyltransferase genes, polypeptides and uses thereof
US6680197B2 (en) * 1998-12-28 2004-01-20 Corixa Corporation Compositions and methods for the therapy and diagnosis of breast cancer
US20040002068A1 (en) * 2000-03-01 2004-01-01 Corixa Corporation Compositions and methods for the detection, diagnosis and therapy of hematological malignancies
US6436703B1 (en) 2000-03-31 2002-08-20 Hyseq, Inc. Nucleic acids and polypeptides
GB0119473D0 (en) * 2001-08-09 2001-10-03 Astrazeneca Compounds
US7193069B2 (en) * 2002-03-22 2007-03-20 Research Association For Biotechnology Full-length cDNA
DE10316701A1 (de) 2003-04-09 2004-11-04 Hinzmann, Bernd, Dr. Humane Nukleinsäuresequenzen aus Bronchialkarzinomen
EP1522594A3 (en) 2003-10-06 2005-06-22 Bayer HealthCare AG Methods and kits for investigating cancer
EP2186894A4 (en) * 2007-07-10 2010-10-20 Shionogi & Co MONOCLONAL ANTIBODY HAVING NEUTRALIZING ACTIVITY AGAINST MMP13
AU2008311869B2 (en) * 2007-10-17 2013-11-21 The Board Of Trustees Of The Leland Stanford Junior University Method and composition for crystallizing G protein-coupled receptors
CN102165688A (zh) 2008-03-31 2011-08-24 新加坡科技研究局 高效率线性发射器
RS53782B1 (sr) 2008-10-01 2015-06-30 Immatics Biotechnologies Gmbh Preparati tumor-asociranih peptida i odgovarajuća antikancerska vakcina za tretman glioblastoma (gbm) i drugih kancera
ITBO20090075A1 (it) * 2009-02-13 2010-08-14 Magneti Marelli Spa Macchina elettrica con singolo statore e due rotori tra loro indipendenti e veicolo stradale provvisto di tale macchina elettrica
WO2012048291A2 (en) * 2010-10-08 2012-04-12 Proteapex Therapeutics Llc Compositions and methods for inhibition of mmp:mmp-substrate interactions
WO2012104344A1 (en) * 2011-02-01 2012-08-09 Genmab A/S Human antibodies and antibody-drug conjugates against cd74
WO2013039477A1 (en) 2011-09-12 2013-03-21 University Of South Alabama Non-invasive methods of detecting target molecules
US9221876B2 (en) 2011-11-11 2015-12-29 Cardiovax, Llc Methods for treating kidney disease with fragments of ApoB-100
WO2013151665A2 (en) 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of proteins associated with human disease
US9254311B2 (en) * 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
WO2014160275A2 (en) 2013-03-14 2014-10-02 Battell Memorial Institute Biomarkers for liver fibrosis
GB201515321D0 (en) * 2015-08-28 2015-10-14 Immatics Biotechnologies Gmbh Novel peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers
AU2017254477A1 (en) * 2016-04-18 2018-11-01 Jennifer G. ABELIN Improved HLA epitope prediction
TW202016131A (zh) * 2018-05-16 2020-05-01 德商英麥提克生物技術股份有限公司 用於抗癌免疫治療的肽
TW202028224A (zh) * 2018-09-17 2020-08-01 德商英麥提克生物技術股份有限公司 B*44限制肽在抗癌免疫治療的用途和相關方法

Patent Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002507397A (ja) * 1998-03-13 2002-03-12 エピミューン，インコーポレイティド Ｈｌａ結合ペプチド及びその使用
WO1999045954A1 (en) * 1998-03-13 1999-09-16 Epimmune, Inc. Hla-binding peptides and their uses
EP1125947A1 (en) * 1998-10-30 2001-08-22 Japan Science and Technology Corporation HUMAN H37 PROTEINS AND cDNAS ENCODING THE SAME
EP1104808A1 (en) * 1999-08-05 2001-06-06 Genset ESTs and encoded human proteins
WO2003016523A1 (en) * 2001-08-21 2003-02-27 Millennium Pharmaceuticals, Inc. Screen for cdc7 inhibitors
WO2004099243A2 (en) * 2003-05-05 2004-11-18 Pharmacia Italia S.P.A. Truncated forms of human dbf4, complexes with their interacting partners and methods for identification of inhibitors thereof
WO2005073374A1 (ja) * 2004-01-29 2005-08-11 Dainippon Sumitomo Pharma Co., Ltd. 新規腫瘍抗原蛋白質及びその利用
CN103911358A (zh) * 2007-07-27 2014-07-09 伊玛提克斯生物技术有限公司 神经元和脑肿瘤的新型免疫疗法
WO2009015842A2 (en) * 2007-07-27 2009-02-05 Immatics Biotechnologies Gmbh Novel immunogenic epitopes for immunotherapy
US20110200626A1 (en) * 2008-06-11 2011-08-18 Oncotherapy Science, Inc. Iqgap3 epitope peptides and vaccines containing the same
WO2010037395A2 (en) * 2008-10-01 2010-04-08 Dako Denmark A/S Mhc multimers in cancer vaccines and immune monitoring
US20110318380A1 (en) * 2008-10-01 2011-12-29 Dako Denmark A/S MHC Multimers in Cancer Vaccines and Immune Monitoring
CN104017067A (zh) * 2009-07-03 2014-09-03 英美偌科有限公司 T细胞受体
US20110229504A1 (en) * 2010-03-19 2011-09-22 Immatics Biotechnologies Gmbh Novel immunotherapy against several tumors including gastrointestinal and gastric cancer
WO2014026277A1 (en) * 2012-08-15 2014-02-20 Université de Montréal Method for identifying novel minor histocompatibility antigens
WO2014043441A1 (en) * 2012-09-14 2014-03-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T cell receptors recognizing mhc class ii-restricted mage-a3
WO2015018805A1 (en) * 2013-08-05 2015-02-12 Immatics Biotechnologies Gmbh Novel immunotherapy against several tumors, such as lung cancer, including nsclc
WO2015092710A1 (en) * 2013-12-19 2015-06-25 Glaxosmithkline Biologicals, S.A. Contralateral co-administration of vaccines

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
781 Sensitive DNA marker panel for detection of pancreatic cancer by assay in pancreatic juice;Massimo Raimondo等;《Gastroenterology》;20140501;第146卷(第5期);第S-132页 *
Functional validation of putative tumor suppressor gene C130RF18 in cervical cancer by artificial transcription factors;Huisman Christian等;《Molecular Oncology》;20130305;第7卷(第3期);第669-679页 *
Integrated functional genomics approach for the design of patient-individual antitumor vaccines;Weinschenk T等;《Cancer Research》;20021015;第62卷(第20期);第5818-5827页 *
Manipulation of MHC-I/TCR interaction for immune therapy;Qingjun Liu等;《Cellular & Molecular Immunology》;20080630;第5卷(第3期);第171-182页 *
The effect of proteasome inhibition on the generation of the Human Leukocyte Antigen(HLA) peptidom;Elena Milner等;《Molecular & Cellular Proteomics》;20130328;第12卷(第7期);第1853-1864页 *
基于MHC-II限制性途径的抗原定向呈递系统原理介绍;付志璇等;《国际免疫学杂志》;20131130;第36卷(第6期);第422-426页 *

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