CN107913294A - A kind of pregnant woman's zinc supplementation nutrient solution - Google Patents
A kind of pregnant woman's zinc supplementation nutrient solution Download PDFInfo
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- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
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- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
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Abstract
The invention mainly relates to New drug discovery formulation technologies field, discloses a kind of pregnant woman's zinc supplementation nutrient solution, is made of following raw material：Zinc gluconate, Kiwi berry, green starch, lentinan, ascorbic acid, folic acid, lactic acid bacteria；Full of nutrition, the smell of fruits is very sweet, sweet mouthfeel, and beneficial to absorption, the absorptivity of zinc reaches 89.2%；Add green starch and Kiwi berry, it is capable of fragrance and the nutrition of abundant nutrition liquid, increase palatability, avoid stimulating intestine and stomach, produce the adverse reactions such as nausea and vomiting, promote embryo growth and development, after green starch and gooseberry mixing, access lactic acid bacteria is fermented, and produces the nutritional ingredient of a large amount of small molecules, promotion is digested and assimilated, strengthen the gastrointestinal function of pregnant woman, improve the digestibility of nutritional ingredient, and the nisin produced can suppress varied bacteria growing, extend the shelf life of nutrient solution, save the cost of storage.
Description
Technical field
The invention mainly relates to New drug discovery formulation technologies field, more particularly to a kind of pregnant woman's zinc supplementation nutrient solution.
Background technology
Zinc is one of the essential trace elements of the human body, can by people titled with " flowers of life ", the laudatory title of " source of intelligence "
Promote the growth and development of human body, increase intelligence, synthesize a variety of enzymes, maintain dysregulated appetite, strengthen body immunity, promote wound to be cured
Close, promote vitamin A absorption, protect eyesight, beauty and skin care.
Pregnant woman's zinc-deficiency can result in pregnancy reaction exacerbation, acidophilus, and vomiting aggravates, intrauterine fetal hypoevolutism, prolonged labor,
Miscarriage, premature labor, fetal anomaly rate increase, but zinc supplementation product currently on the market, and meeting stimulating intestine and stomach, causes nausea and vomiting,
Zinc supplementation rate is low, and therefore, it is necessary to pregnant woman's zinc supplementation nutrient solution that a kind of palatability is good, absorptivity is high, without side-effects.
The content of the invention
The defects of in order to make up prior art, the object of the present invention is to provide a kind of pregnant woman's zinc supplementation nutrient solution.
A kind of pregnant woman's zinc supplementation nutrient solution, is made of the raw material of following parts by weight：Zinc gluconate 95 ~ 97, Kiwi berry 17 ~
19th, green starch 11 ~ 13, lentinan 6 ~ 8, ascorbic acid 0.07 ~ 0.09, folic acid 0.06 ~ 0.08, lactic acid bacteria 3 ~ 5.
The Kiwi berry, is the red kiwifruit of fresh mature.
The green starch, the green starch prepared for the fresh mung bean that harvests then, during immersion, GREEN PEAS and mung bean
The weight ratio of grain is 1:12~14.
The lactic acid bacteria, is made of the raw material of following parts by weight：Lactobacillus delbrueckii 12 ~ 14, Kefir grains 12 ~ 14, acidophilus
Lactobacillus 7 ~ 9, lactobacillus bulgaricus 6 ~ 8.
A kind of preparation method of pregnant woman's zinc supplementation nutrient solution, comprises the following steps：
（1）Kiwi berry is cleaned, is removed the peel, adds ascorbic acid, mashing, adds 5 ~ 6 times of pure water measured of Kiwi berry weight, grinding
It is 180 ~ 200 mesh to particle diameter, obtains gooseberry；
（2）Green starch is added in gooseberry, is capable of fragrance and the nutrition of abundant nutrition liquid, increases palatability, avoids piercing
Swash stomach, produce the adverse reaction such as nausea and vomiting, promote embryo growth and development, be uniformly mixed, access lactic acid bacteria, it is placed in 41 ~
When 43 DEG C of ferment at constant temperature 5 ~ 6 are small, be cooled to 23 ~ 25 DEG C, be uniformly mixed, continue fermentation 8 ~ 10 it is small when, produce a large amount of small molecules
Nutritional ingredient, promotes to digest and assimilate, and strengthens the gastrointestinal function of pregnant woman, improves the digestibility of nutritional ingredient, and produce
Nisin can suppress varied bacteria growing, extend the shelf life of nutrient solution, save the cost of storage, obtain fermentation slurry；
（3）Zinc gluconate is added into fermentation slurry, adds the water of 1.6 ~ 1.8 times of amounts of zinc gluconate weight, is stirred to completely molten
Solution, adds lentinan and folic acid, the fragrance for the liquid that has additional nutrients and nutrition, supplements the nutritional ingredient needed for pregnant woman, strengthens pregnant woman
Resistance, promotes embryo growth and development, is uniformly mixed, and is placed in 121 DEG C and sterilizes 20 ~ 25 minutes, obtains pregnant woman's zinc supplementation nutrient solution；
（4）Packaging, examines, obtains finished product.
The step（4）Packaging, be filled with nitrogen after packaging, capacity is 5ml/ branch.
The drinking method of pregnant woman's zinc supplementation nutrient solution, drinks during dining or in dining half an hour after, drinks 1 daily,
Nutrient solution is free of any additive, safe and healthy, drinks conveniently.
It is an advantage of the invention that：A kind of pregnant woman's zinc supplementation nutrient solution provided by the invention, full of nutrition, the smell of fruits is very sweet, mouthfeel
Sour-sweet, beneficial to absorption, the absorptivity of zinc reaches 89.2%；Add green starch and Kiwi berry, be capable of abundant nutrition liquid fragrance and
Nutrition, increases palatability, avoids stimulating intestine and stomach, produces the adverse reactions such as nausea and vomiting, promotes embryo growth and development, and mung bean forms sediment
After powder and gooseberry mixing, access lactic acid bacteria is fermented, and is produced the nutritional ingredient of a large amount of small molecules, is promoted to digest and assimilate,
Strengthen the gastrointestinal function of pregnant woman, improve the digestibility of nutritional ingredient, and the nisin produced can suppress miscellaneous
Bacterium grows, and extends the shelf life of nutrient solution, saves the cost of storage；Remaining raw material is added after fermentation, the fragrance for the liquid that has additional nutrients
And nutrition, the nutritional ingredient needed for pregnant woman is supplemented, strengthens pregnant woman's resistance, promotes embryo growth and development；Nutrient solution is without any
Additive, it is safe and healthy, drink conveniently.
Embodiment
Illustrate the present invention with specific embodiment below.
Embodiment 1
A kind of pregnant woman's zinc supplementation nutrient solution, is made of the raw material of following parts by weight：Zinc gluconate 95, Kiwi berry 17, green starch
11st, lentinan 6, ascorbic acid 0.07, folic acid 0.06, lactic acid bacteria 3.
The Kiwi berry, is the red kiwifruit of fresh mature.
The green starch, the green starch prepared for the fresh mung bean that harvests then, during immersion, GREEN PEAS and mung bean
The weight ratio of grain is 1:12.
The lactic acid bacteria, is made of the raw material of following parts by weight：Lactobacillus delbrueckii 12, Kefir grains 12, lactobacillus acidophilus
7th, lactobacillus bulgaricus 6.
A kind of preparation method of pregnant woman's zinc supplementation nutrient solution, comprises the following steps：
（1）Kiwi berry is cleaned, is removed the peel, adds ascorbic acid, mashing, adds the pure water of 5 times of amounts of Kiwi berry weight, be ground to
Particle diameter is 200 mesh, obtains gooseberry；
（2）Green starch is added in gooseberry, is capable of fragrance and the nutrition of abundant nutrition liquid, increases palatability, avoids piercing
Swash stomach, produce the adverse reactions such as nausea and vomiting, promote embryo growth and development, be uniformly mixed, access lactic acid bacteria, be placed in 43 DEG C
When ferment at constant temperature 6 is small, be cooled to 25 DEG C, be uniformly mixed, continue fermentation 9 it is small when, produce the nutritional ingredients of a large amount of small molecules, promote
Digest and assimilate, strengthen the gastrointestinal function of pregnant woman, improve the digestibility of nutritional ingredient, and the nisin energy produced
Enough suppress varied bacteria growing, extend the shelf life of nutrient solution, save the cost of storage, obtain fermentation slurry；
（3）Zinc gluconate is added into fermentation slurry, adds the water of 1.7 times of amounts of zinc gluconate weight, stirs to being completely dissolved, adds
Enter lentinan and folic acid, the fragrance for the liquid that has additional nutrients and nutrition, supplement the nutritional ingredient needed for pregnant woman, enhancing pregnant woman's resistance
Power, promotes embryo growth and development, is uniformly mixed, and is placed in 121 DEG C and sterilizes 20 ~ 25 minutes, obtains pregnant woman's zinc supplementation nutrient solution；
（4）Packaging, examines, obtains finished product.
The step（4）Packaging, be filled with nitrogen after packaging, capacity is 5ml/ branch.
The drinking method of pregnant woman's zinc supplementation nutrient solution, drinks during dining or in dining half an hour after, drinks 1 daily,
Nutrient solution is free of any additive, safe and healthy, drinks conveniently.
Embodiment 2
A kind of pregnant woman's zinc supplementation nutrient solution, is made of the raw material of following parts by weight：Zinc gluconate 96, Kiwi berry 18, green starch
12nd, lentinan 7, ascorbic acid 0.08, folic acid 0.07, lactic acid bacteria 4.
The Kiwi berry, is the red kiwifruit of fresh mature.
The green starch, the green starch prepared for the fresh mung bean that harvests then, during immersion, GREEN PEAS and mung bean
The weight ratio of grain is 1:13.
The lactic acid bacteria, is made of the raw material of following parts by weight：Lactobacillus delbrueckii 13, Kefir grains 13, lactobacillus acidophilus
8th, lactobacillus bulgaricus 7.
Prepare and drinking method is the same as embodiment 1.
Embodiment 3
A kind of pregnant woman's zinc supplementation nutrient solution, is made of the raw material of following parts by weight：Zinc gluconate 97, Kiwi berry 19, green starch
13rd, lentinan 8, ascorbic acid 0.09, folic acid 0.08, lactic acid bacteria 5.
The Kiwi berry, is the red kiwifruit of fresh mature.
The green starch, the green starch prepared for the fresh mung bean that harvests then, during immersion, GREEN PEAS and mung bean
The weight ratio of grain is 1:14.
The lactic acid bacteria, is made of the raw material of following parts by weight：Lactobacillus delbrueckii 14, Kefir grains 14, lactobacillus acidophilus
9th, lactobacillus bulgaricus 8.
Prepare and drinking method is the same as embodiment 1.
Comparative example 1
Kiwi berry is removed, remaining is prepared and drinking method, with embodiment 1.
Comparative example 2
Green starch is removed, remaining is prepared and drinking method, with embodiment 1.
Comparative example 3
Lentinan is removed, remaining is prepared and drinking method, with embodiment 1.
Comparative example 4
Ascorbic acid and folic acid are removed, remaining is prepared and drinking method, with embodiment 1.
Comparative example 5
Lactic acid bacteria is removed, remaining is prepared and drinking method, with embodiment 1.
Comparative example 5
Removal step（3）, all raw materials are in step（2）Middle addition, remaining is prepared and drinking method, with embodiment 1.
Comparative example 6
The zinc gluconate oral administration solution of existing commercially available Henan Ling Rui stores pharmacy.
The zinc supplementation effect of embodiment and comparative example zinc supplementation nutrient solution：
Detergent Kunming is randomly choosed into mouse 100,10 groups is randomly divided into, is respectively 3 embodiment groups, 6 comparative example groups and 1
A blank control group, every group 10, half male and half female, respectively with embodiment and the zinc supplementation nutrient solution gavage of the comparative example group into
Mouse, proportionately mouse batheroom scale, gavage amount are 1ml/kg, the physiological saline of blank control group gavage equivalent, free water, continuous feeding
30 days, it is calculated as the abdominal fat, free radical and blood glucose of mouse, the zinc supplementation effect of embodiment and comparative example zinc supplementation nutrient solution is shown in Table 1.
Table 1：The zinc supplementation effect of embodiment and comparative example zinc supplementation nutrient solution
| Project | Abdominal fat（%） | Free radical（106cd/ml） | Blood glucose（mmol/L） |
| Embodiment 1 | 2.2 | 1.68 | 7.78 |
| Embodiment 2 | 2.4 | 1.65 | 7.81 |
| Embodiment 3 | 2.1 | 1.67 | 7.79 |
| Comparative example 1 | 2.8 | 1.72 | 8.13 |
| Comparative example 2 | 2.6 | 1.70 | 8.21 |
| Comparative example 3 | 2.7 | 1.71 | 8.18 |
| Comparative example 4 | 2.9 | 1.74 | 8.47 |
| Comparative example 5 | 3.1 | 1.68 | 8.32 |
| Comparative example 6 | 3.2 | 1.79 | 8.86 |
| Blank control group | 2.0 | 1.65 | 7.68 |
From table 1 the result shows that, embodiment pregnant woman zinc supplementation nutrient solution gavage is into after mouse, and the abdominal fat into mouse is small, free radical and blood
Sugared content is less, suitable with blank control group, illustrates that pregnant woman's zinc supplementation nutrient solution provided by the invention has good zinc supplementation effect.
The malicious combability measurements of embodiment and comparative example pregnant woman's zinc supplementation nutrient solution：
Pregnant woman's zinc supplementation nutrient solution of appropriate embodiment and comparative example is taken respectively, it is spare.
（1）Rat oral acute toxicity test：
Experimental group：Big white mouse 100, is randomly divided into 10 groups, every group 10, half male and half female, respectively by embodiment and comparative example
Pregnant woman's zinc supplementation nutrient solution gives experiment rat by the oral gavage of 1ml/kgbw amounts, is given once per 4h, observes 7d after four times, see
Any poisoning symptom is whether there is to see；Negative control group：Experimental animal 10, half male and half female, does not give pregnant woman's zinc supplementation nutrient solution, with examination
Group controlled observation at the same time is tested, the results are shown in Table 3；
（2）Mouse inbred strain：
Experimental group：Male mice 110, is randomly divided into 11 groups, every group 10, respectively by pregnant woman's zinc supplementation of embodiment and comparative example
Nutrient solution presses the amount of 1ml/kgbw, the male mice of the continuous 5d difference gavages group；Positive controls：It will easily cause mouse smart
The mitomycin C of son distortion presses the male mice of the 1ml/kgbw dosage continuous 5d gavages group；Negative control group：It will be not easy to draw
The distilled water of mouse sperm distortion is played by the male mice of the 1ml/kgbw dosage continuous 5d gavages group, the results are shown in Table 2；
Table 2：The malicious combability measurements of embodiment and comparative example pregnant woman's zinc supplementation nutrient solution
| Project | Rat oral acute toxicity test | Micronucleus number/(‰) |
| Embodiment 1 | None is abnormal or dead | 1.72 |
| Embodiment 2 | None is abnormal or dead | 1.71 |
| Embodiment 3 | None is abnormal or dead | 1.72 |
| Comparative example 1 | None is abnormal or dead | 1.74 |
| Comparative example 2 | None is abnormal or dead | 1.71 |
| Comparative example 3 | None is abnormal or dead | 1.73 |
| Comparative example 4 | None is abnormal or dead | 1.73 |
| Comparative example 5 | None is abnormal or dead | 1.74 |
| Comparative example 6 | None is abnormal or dead | 1.72 |
| Positive controls | — | 18.48 |
| Negative control group | None is abnormal or dead | 1.74 |
Note："-" indicate without.
From table 2 the result shows that, pregnant woman's zinc supplementation nutrient solution of the invention is right with feminine gender after rat oral acute toxicity test
Identical according to organizing, none is abnormal or dead, shows that pregnant woman's zinc supplementation nutrient solution provided by the invention is safe and non-toxic, mouse sperm deformity
After experiment, the mouse sperm deformity rate of embodiment is suitable with negative control group, hence it is evident that less than positive controls, shows that the present invention carries
Pregnant woman's zinc supplementation nutrient solution of confession will not produce detrimental effect to the reproduction cell of mouse.
Claims (7)
1. a kind of pregnant woman's zinc supplementation nutrient solution, it is characterised in that be made of the raw material of following parts by weight：Zinc gluconate 95 ~ 97, Mi
Monkey peach 17 ~ 19, green starch 11 ~ 13, lentinan 6 ~ 8, ascorbic acid 0.07 ~ 0.09, folic acid 0.06 ~ 0.08, lactic acid bacteria 3 ~
5。
2. pregnant woman's zinc supplementation nutrient solution according to claim 1, it is characterised in that the Kiwi berry, is the red of fresh mature
Heart Kiwi berry.
3. pregnant woman's zinc supplementation nutrient solution according to claim 1, it is characterised in that the green starch, harvests then
Green starch prepared by fresh mung bean, during immersion, the weight ratio of GREEN PEAS and mung bean grain is 1:12~14.
4. pregnant woman's zinc supplementation nutrient solution according to claim 1, it is characterised in that the lactic acid bacteria, by following parts by weight
Raw material forms：Lactobacillus delbrueckii 12 ~ 14, Kefir grains 12 ~ 14, lactobacillus acidophilus 7 ~ 9, lactobacillus bulgaricus 6 ~ 8.
5. a kind of preparation method of the zinc supplementation nutrient solution of pregnant woman according to claim 1, it is characterised in that comprise the following steps：
（1）Kiwi berry is cleaned, is removed the peel, adds ascorbic acid, mashing, adds 5 ~ 6 times of pure water measured of Kiwi berry weight, grinding
It is 180 ~ 200 mesh to particle diameter, obtains gooseberry；
（2）Green starch is added in gooseberry, is uniformly mixed, lactic acid bacteria is accessed, it is small to be placed in 41 ~ 43 DEG C of ferment at constant temperature 5 ~ 6
When, be cooled to 23 ~ 25 DEG C, be uniformly mixed, continue fermentation 8 ~ 10 it is small when, obtain fermentation slurry；
（3）Zinc gluconate is added into fermentation slurry, adds the water of 1.6 ~ 1.8 times of amounts of zinc gluconate weight, is stirred to completely molten
Solution, adds lentinan and folic acid, is uniformly mixed, and is placed in 121 DEG C and sterilizes 20 ~ 25 minutes, obtains pregnant woman's zinc supplementation nutrient solution；
（4）Packaging, examines, obtains finished product.
6. the preparation method of pregnant woman's zinc supplementation nutrient solution according to claim 5, it is characterised in that the step（4）Packaging,
Nitrogen is filled with after packaging, capacity is 5ml/ branch.
7. according to the drinking method of any one of claim 1 ~ 6 pregnant woman's zinc supplementation nutrient solution, it is characterised in that during dining or into
Drunk in postprandial half an hour, drink 1 daily.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2281054A1 (en) * | 1998-09-03 | 2000-03-03 | John C. Godfrey | Combination of zinc ions and vitamin c and method of making |
| CN102379899A (en) * | 2011-07-20 | 2012-03-21 | 吉林敖东集团大连药业股份有限公司 | Compound vitamin medicinal composition and preparation method thereof |
-
2017
- 2017-10-31 CN CN201711041498.6A patent/CN107913294A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2281054A1 (en) * | 1998-09-03 | 2000-03-03 | John C. Godfrey | Combination of zinc ions and vitamin c and method of making |
| CN102379899A (en) * | 2011-07-20 | 2012-03-21 | 吉林敖东集团大连药业股份有限公司 | Compound vitamin medicinal composition and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 何昌善等: "《临症用药纲目》", 31 August 2017, 中国医药科技出版社 * |
| 李俊轩等: "《新编实用药物制剂及合理应用》", 31 January 2006, 中国科学技术出版社 * |
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