CN107897381A - A kind of modulation milk powder of adjustment function of intestinal canal containing lactase and preparation method thereof - Google Patents
A kind of modulation milk powder of adjustment function of intestinal canal containing lactase and preparation method thereof Download PDFInfo
- Publication number
- CN107897381A CN107897381A CN201711458970.6A CN201711458970A CN107897381A CN 107897381 A CN107897381 A CN 107897381A CN 201711458970 A CN201711458970 A CN 201711458970A CN 107897381 A CN107897381 A CN 107897381A
- Authority
- CN
- China
- Prior art keywords
- milk powder
- lactase
- raw material
- adjustment function
- intestinal canal
- Prior art date
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- Pending
Links
- 239000000843 powder Substances 0.000 title claims abstract description 73
- 102100026189 Beta-galactosidase Human genes 0.000 title claims abstract description 56
- 108010059881 Lactase Proteins 0.000 title claims abstract description 56
- 108010005774 beta-Galactosidase Proteins 0.000 title claims abstract description 56
- 229940116108 lactase Drugs 0.000 title claims abstract description 55
- 235000013336 milk Nutrition 0.000 title claims abstract description 55
- 239000008267 milk Substances 0.000 title claims abstract description 55
- 210000004080 milk Anatomy 0.000 title claims abstract description 55
- 230000000968 intestinal effect Effects 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 239000002994 raw material Substances 0.000 claims abstract description 28
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 21
- 239000008101 lactose Substances 0.000 claims abstract description 21
- 239000006041 probiotic Substances 0.000 claims abstract description 21
- 235000018291 probiotics Nutrition 0.000 claims abstract description 21
- 235000013406 prebiotics Nutrition 0.000 claims abstract description 19
- 102000014171 Milk Proteins Human genes 0.000 claims abstract description 14
- 108010011756 Milk Proteins Proteins 0.000 claims abstract description 14
- 235000021239 milk protein Nutrition 0.000 claims abstract description 14
- 150000001720 carbohydrates Chemical class 0.000 claims abstract description 12
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 235000014633 carbohydrates Nutrition 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 11
- 241000901050 Bifidobacterium animalis subsp. lactis Species 0.000 claims description 10
- 229940009289 bifidobacterium lactis Drugs 0.000 claims description 10
- 238000003860 storage Methods 0.000 claims description 10
- 235000008939 whole milk Nutrition 0.000 claims description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 241000218588 Lactobacillus rhamnosus Species 0.000 claims description 7
- 238000004320 controlled atmosphere Methods 0.000 claims description 7
- 238000000855 fermentation Methods 0.000 claims description 7
- 230000004151 fermentation Effects 0.000 claims description 7
- 238000004806 packaging method and process Methods 0.000 claims description 7
- 108090000790 Enzymes Proteins 0.000 claims description 6
- 102000004190 Enzymes Human genes 0.000 claims description 6
- 229920002774 Maltodextrin Polymers 0.000 claims description 6
- 239000005913 Maltodextrin Substances 0.000 claims description 6
- 102000007544 Whey Proteins Human genes 0.000 claims description 6
- 108010046377 Whey Proteins Proteins 0.000 claims description 6
- 239000001569 carbon dioxide Substances 0.000 claims description 6
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 6
- 229940088598 enzyme Drugs 0.000 claims description 6
- 235000020190 lactose-free milk Nutrition 0.000 claims description 6
- 229940035034 maltodextrin Drugs 0.000 claims description 6
- 240000006439 Aspergillus oryzae Species 0.000 claims description 5
- 235000002247 Aspergillus oryzae Nutrition 0.000 claims description 5
- 241001465754 Metazoa Species 0.000 claims description 5
- 229920001202 Inulin Polymers 0.000 claims description 4
- 240000001046 Lactobacillus acidophilus Species 0.000 claims description 4
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 claims description 4
- UQZIYBXSHAGNOE-USOSMYMVSA-N Stachyose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO[C@@H]2[C@@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O2)O1 UQZIYBXSHAGNOE-USOSMYMVSA-N 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 4
- 235000021255 galacto-oligosaccharides Nutrition 0.000 claims description 4
- 150000003271 galactooligosaccharides Chemical class 0.000 claims description 4
- 235000020256 human milk Nutrition 0.000 claims description 4
- 210000004251 human milk Anatomy 0.000 claims description 4
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims description 4
- 229940029339 inulin Drugs 0.000 claims description 4
- 229940039695 lactobacillus acidophilus Drugs 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- JCXJVPUVTGWSNB-UHFFFAOYSA-N nitrogen dioxide Inorganic materials O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 claims description 4
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- 238000001694 spray drying Methods 0.000 claims description 4
- UQZIYBXSHAGNOE-XNSRJBNMSA-N stachyose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@@H]3[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O3)O)O2)O)O1 UQZIYBXSHAGNOE-XNSRJBNMSA-N 0.000 claims description 4
- 230000001954 sterilising effect Effects 0.000 claims description 4
- 238000004659 sterilization and disinfection Methods 0.000 claims description 4
- 235000021119 whey protein Nutrition 0.000 claims description 4
- 241000228245 Aspergillus niger Species 0.000 claims description 3
- 241000186000 Bifidobacterium Species 0.000 claims description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 3
- 239000008103 glucose Substances 0.000 claims description 3
- 238000012856 packing Methods 0.000 claims description 3
- 241000235058 Komagataella pastoris Species 0.000 claims description 2
- 241000186604 Lactobacillus reuteri Species 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 239000005862 Whey Substances 0.000 claims description 2
- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 229940001882 lactobacillus reuteri Drugs 0.000 claims description 2
- 230000000813 microbial effect Effects 0.000 claims description 2
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- 150000002482 oligosaccharides Chemical class 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
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- 238000012545 processing Methods 0.000 claims description 2
- 235000020183 skimmed milk Nutrition 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 239000006188 syrup Substances 0.000 claims description 2
- DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 claims 2
- 244000285963 Kluyveromyces fragilis Species 0.000 claims 1
- 235000014663 Kluyveromyces fragilis Nutrition 0.000 claims 1
- 102000004407 Lactalbumin Human genes 0.000 claims 1
- 108090000942 Lactalbumin Proteins 0.000 claims 1
- 229920001100 Polydextrose Polymers 0.000 claims 1
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- 235000013856 polydextrose Nutrition 0.000 claims 1
- 239000001259 polydextrose Substances 0.000 claims 1
- 235000021241 α-lactalbumin Nutrition 0.000 claims 1
- 201000010538 Lactose Intolerance Diseases 0.000 abstract description 25
- 208000024891 symptom Diseases 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 11
- 235000013365 dairy product Nutrition 0.000 abstract description 6
- 101710195294 Beta-galactosidase 1 Proteins 0.000 abstract description 2
- 210000002249 digestive system Anatomy 0.000 abstract 1
- 235000005911 diet Nutrition 0.000 description 8
- 230000037213 diet Effects 0.000 description 8
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 8
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- 238000012360 testing method Methods 0.000 description 6
- 206010023648 Lactase deficiency Diseases 0.000 description 5
- 230000009286 beneficial effect Effects 0.000 description 5
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- 239000002253 acid Substances 0.000 description 4
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- 230000006872 improvement Effects 0.000 description 4
- 239000004310 lactic acid Substances 0.000 description 4
- 235000014655 lactic acid Nutrition 0.000 description 4
- 206010000060 Abdominal distension Diseases 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 230000000996 additive effect Effects 0.000 description 3
- 210000000481 breast Anatomy 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000000529 probiotic effect Effects 0.000 description 3
- 241000193830 Bacillus <bacterium> Species 0.000 description 2
- 101710195293 Beta-galactosidase 2 Proteins 0.000 description 2
- 101710195318 Beta-galactosidase 3 Proteins 0.000 description 2
- 208000002881 Colic Diseases 0.000 description 2
- 206010067715 Gastrointestinal sounds abnormal Diseases 0.000 description 2
- 241000235649 Kluyveromyces Species 0.000 description 2
- 241000186660 Lactobacillus Species 0.000 description 2
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- 238000001514 detection method Methods 0.000 description 2
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- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 2
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- YTBSYETUWUMLBZ-QWWZWVQMSA-N D-threose Chemical compound OC[C@@H](O)[C@H](O)C=O YTBSYETUWUMLBZ-QWWZWVQMSA-N 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 1
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
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- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 235000020244 animal milk Nutrition 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
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- RIZIAUKTHDLMQX-UHFFFAOYSA-N cerebroside D Natural products CCCCCCCCCCCCCCCCC(O)C(=O)NC(C(O)C=CCCC=C(C)CCCCCCCCC)COC1OC(CO)C(O)C(O)C1O RIZIAUKTHDLMQX-UHFFFAOYSA-N 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
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- 235000020247 cow milk Nutrition 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000006694 eating habits Nutrition 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 235000021001 fermented dairy product Nutrition 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 206010016766 flatulence Diseases 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 229960002737 fructose Drugs 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000034659 glycolysis Effects 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 244000005706 microflora Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
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- 239000005017 polysaccharide Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 235000021391 short chain fatty acids Nutrition 0.000 description 1
- 150000004666 short chain fatty acids Chemical class 0.000 description 1
- 235000000891 standard diet Nutrition 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/16—Agglomerating or granulating milk powder; Making instant milk powder; Products obtained thereby
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C3/00—Preservation of milk or milk preparations
- A23C3/005—Storing or packaging in a vacuum or in inert or sterile gaseous atmosphere
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/156—Flavoured milk preparations ; Addition of fruits, vegetables, sugars, sugar alcohols or sweeteners
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/113—Acidophilus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/173—Reuteri
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/175—Rhamnosus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/515—Animalis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Dairy Products (AREA)
Abstract
A kind of modulation milk powder of adjustment function of intestinal canal containing lactase and preparation method thereof, which consists of the following components in percentage by weight：Milk powder 50 80%, milk proteins raw material and/or carbohydrate raw material 5 30%, prebiotics 5 15%, lactase 1 5% and probiotics 0.3 1.5%.Present invention additionally comprises the preparation method of the modulation milk powder of the adjustment function of intestinal canal containing lactase.The modulation milk powder of the adjustment function of intestinal canal containing lactase of the present invention, contain lactase, probiotics and prebiotics, the adjusting intestinal microecology and digestive system contributed to, coordinating other lactinated dairy products to be used together can help to reduce lactose, and play the effect for alleviating lactose intolerance symptom.
Description
Technical field
The present invention relates to food and medicine technical field, and in particular to a kind of modulation of the adjustment function of intestinal canal containing lactase
Milk powder and preparation method thereof.
Background technology
Lactose：Existed only in nature in the milk of mammal, a molecule lactose digestion can get a point sub- grape
Sugar and a molecule galactolipin.Lactose is the important energy source of infant in breast milk, and galactolipin can promote cerebroside and stick
The generation of polysaccharide, thus infant intelligence is developed extremely important.But the lactose as disaccharide must divide under lactose enzyme effect
Solution could be immediately used by the body into galactolipin and glucose by intestinal absorption.
Lactose intolerance：Lactose intolerance is due to that lactose enzyme secretion is few, it is impossible to which digestion is decomposed in breast milk or cow's milk completely
Lactose caused by noninfectious diarrhea, also known as lactase deficiency.Lactose intolerance is generally divided into three kinds：Congenital lactose
Azymia, secondary lactase deficiency, adult type alactasia.Due to internal lactase lack or activity reduce, it is impossible to very
Good digestion lactose, portion of Lactose is by colonic microflora glycolysis into lactic acid, hydrogen, methane and carbon dioxide.Lactic acid stimulates intestinal wall, increases
Add enterocinesia and diarrhea occur.Carbon dioxide produces flatulence and increase enterocinesia in enteron aisle, shows children uneasy, once in a while also
Enterospasm may be induced and intestinal colic occur.The increase of lactic acid also reduces the pH value of excrement.Therefore, there are abdominal distension, diarrhea, intestines
Ring, intestinal colic, the smelly lactose intolerance symptom such as just of acid.
For most of mammals（Including the mankind）For, lactase can maintain greater activity, most people before 2 years old
Lactase activity continue then to gradually decrease down the level of adult to 2-15 Sui, be about that normal infant enzyme activity is horizontal
10%.But only found at present with the mankind of part, lactase can keep activity to adult, or even throughout one's life.The breast of mankind ancestors
Carbohydrase is initially also like other animals equally without continuation, as the development of cultivation culture, animal are raised and train as domestic animal, people
Dairy produce is drunk or be made to collection animal milk, and as the pith of diet, the mankind constantly adapted to eating habit
Cheng Zhong, experienced the pressure of natural selection and obtains the continuation of lactase activity；Due to different food environments and custom
Difference, for lactose intolerance there is also the racial difference by genetic determination, white people's particularly Nordics group incidence is substantially low,
Such as Northern Europe 2%-15%, Central Europe 9%-23%, American caucasian 6%-22%, India north 20%-30%, and it is reachable in Asia illness rate
95%-100%.Chinese are the group of people at high risks of lactose intolerance, and alactasia incidence is in 80%-95%.Chinese children lactose
Enzymoprivic incidence is raised with the growth at age, the generation of alactasia in the children of 3-5 Sui, 7-8 Sui and 11-13 Sui
Rate is respectively 38.5%, 87.6% and 87.8%, and lactose intolerance incidence is 12.2%, 32.2% and 29%.
The solution of existing lactose intolerance：
1st, it is a small amount of repeatedly to eat lactinated dairy products, avoid drink milk on an empty stomach：Lactose intolerance symptom can be mitigated, but cannot be basic
Solve the problems, such as, lactose cannot absorb well；
2nd, fermented dairy product is selected：Can mitigate lactose intolerance symptom, it is fermented after dairy products trophic structure change, and
It has been not easy to keep for a long time；
3rd, lactose-free milk powder is selected：It is quick, but the lactose in dairy products is eliminated, it is unfavorable for infant's growth and development, easily
Cause malnutrition.
Therefore, there is an urgent need for a kind of scheme that can effectively solve lactose intolerance at present.
The content of the invention
The technical problems to be solved by the invention are, for caused by the shortage of the frequently-occurring and lactase of lactose intolerance
The situation of dairy products cannot be used well, there is provided a kind of modulation milk powder of adjustment function of intestinal canal containing lactase and its preparation side
Method.The product can adjust human body intestinal canal flora and contribute to digesting and assimilating for lactose, can effectively alleviate lactose intolerance
Symptom, has a good application prospect.
The technical solution adopted by the present invention to solve the technical problems is：A kind of tune of the adjustment function of intestinal canal containing lactase
Milk powder processed, consists of the following components in percentage by weight：Milk powder 50-80%, milk proteins raw material and/or carbohydrate are former
Expect 5-30%, prebiotics 5-15%, lactase 1-5% and probiotics 0.3-1.5%；The sum of described each component percentage by weight is
100%。
Further, the lactase refers to the lactase of microbial fermentation extraction：From aspergillus oryzae, aspergillus niger, crisp wall
Kluyveromyces, newborn kluyveromyces and pichia pastoris yeast, the acid lactose of the preferred aspergillus oryzae fermentation extraction of above raw material
Enzyme, the enzyme activity of the acid lactase that the aspergillus oryzae fermentation is extracted in the product cannot be less than 2000ALU/g.
Further, the probiotics for lactobacillus acidophilus, animal bifidobacteria, bifidobacterium lactis, Lactobacillus rhamnosus and
One or more of mixtures in lactobacillus reuteri, the preferred Lactobacillus rhamnosus of above raw material and bifidobacterium lactis combination,
The total viable count of the Lactobacillus rhamnosus and bifidobacterium lactis combination in the product must not be less than 1 × 108CFU/g。
Further, the prebiotics is oligofructose, galactooligosaccharide, xylo-oligosaccharide, oligoisomaltose, poly- grape
One or more of mixtures in sugar, inulin, human milk oligosaccharides HMO and stachyose, the preferred oligofructose of above raw material and water
Threose.
Further, the milk powder is the one or more in whole milk powder, skimmed milk power, lactose-free milk powder and fermentation milk powder
Mixture.
Further, the milk proteins raw material for concentrated whey protein powder, milk protein peptides, sepg whey albumen powder, α-
One or more of mixtures in lactoalbumin.
Further, the carbohydrate raw material is one kind in maltodextrin, starch, corn-syrup solids and glucose
Or several mixture.
Further, contained by each basic preparation unit of the modulation milk powder of the adjustment function of intestinal canal containing lactase
Lactase is 2000-10000ALU；Probiotics is 1.0 × 108-1.0×1010CFU；Prebiotics is 0.1-1.5g.
Its preparation method, using wet processing, comprises the following steps：
（1）Dispensing：Milk powder, milk proteins raw material and/or carbohydrate raw material, prebiotics are mixed by predetermined ratio, then
Add water and mix, then squeeze into temporary storage tank；
Or take and the whole milk of the equal dry matter content of milk powder and milk proteins raw material and/or carbohydrate in formula
Raw material, prebiotics squeeze into temporary storage tank after mixing；
（2）Homogeneous：Homogeneous is carried out to material in temporary storage tank under the conditions of 55-65 DEG C of temperature, pressure 15-22MPa；
（3）Sterilization：It will be sterilized 20-25 seconds under the conditions of 85-92 DEG C of temperature by the mixed liquor of homogeneous；
（4）Concentration：Under the conditions of vacuum -21~-8kPa, 55-65 DEG C of temperature, 17-21 ° of B é is concentrated into；
（5）Spray drying：By by concentration mixed liquor pressure be 15-25 MPa, feeding inlet air temperature be 170-210
DEG C, temperature of outgoing air be 80-90 DEG C under conditions of be spray-dried；
（6）Cool：Room temperature will be cooled down to through fluid bed by dry mixed liquor, water content is 2.0- in material
3.5wt%, then adds probiotics by predetermined ratio（Freeze-dried powder）And lactase, it is uniformly mixed in screw mixer；
（7）Packaging, controlled atmosphere pouch-packaged is carried out using vacuum nitrogen or carbon dioxide（2g/ bags）, obtain final products.
Further, step（1）In, add milk powder, milk proteins raw material and/or carbohydrate raw material, prebiotics weight
The sum of 3-4 times of water.
Further, step（6）In, incorporation time is 15-30 minutes, preferably 20 minutes.
Its preparation method, using dry process, comprises the following steps：
（1）Level-one is dry-mixed：Take predetermined ratio 5-15wt%（It is preferred that 10%）Milk powder, with the probiotics of predetermined ratio（Freeze-dried powder）、
Lactase is put into three-dimensional mixer, is uniformly mixed according to operational procedure, and material is through two-phase transportation into mixer；
（2）Two level is dry-mixed：By the remaining milk powder of predetermined ratio, milk proteins raw material and/or carbohydrate with predetermined ratio
In raw material, prebiotics input mixer, it is uniformly mixed according to operational procedure with the dry-mixed product of level-one, two-phase transportation to packing machine；
（3）Packaging, controlled atmosphere pouch-packaged is carried out using vacuum nitrogen or carbon dioxide（2g/ bags）, obtain final products.
Research shows that the acid lactase of the fermentation such as aspergillus niger and aspergillus oryzae extraction can act as under acidic pH environment
With, it can be reduced lactose by stomach to enteron aisle in enteron aisle, alleviation lactose intolerance symptom.
Probiotics and the digestion of internal lactose have very big relation, some Bifidobacteriums, lactobacillus and streptococcus can divide
Internal lactose is solved, produces some lactic acid, but does not produce gas, while is conducive to the absorption of internal short chain fatty acids；And acidophilus is newborn
Bacillus can be metabolized in vivo, produce lactase, be also beneficial to digesting and assimilating for internal lactose, this can improve lactose intolerance
Symptom.In addition, probiotics can suppress breeding of the harmful bacteria in enteron aisle, toxin is reduced, promotes intestines peristalsis, so as to improve
Enteron aisle function, improves defecation condition.
Probiotics, can be by improving the balance and performance of enteric microorganism, so as to host when reaching enough dosage
Beneficial effect is produced, such as promotion enteron aisle is unobstructed, improves intestinal environment, suppresses diarrhea, alleviates lactose intolerance, improves immunity
Deng.
Prebiotics can be by one kind stimulated in colon of selectivity or the growth of a few bacterium or activity and right
Host produces beneficial effect, and the viability and propagation energy of probiotics can be significantly enhanced by selectively adding prebiotics
Power.Prebiotics is added in product containing profitable probliotics, can increase the viable count in product and extend shelf life, so as to cause
The number of viable cells increase of the beneficial bacterium of intake.
Therefore, in the modulation milk powder for the adjustment function of intestinal canal containing lactase that the present invention designs, lactase, probiotics and benefit
Raw member can mutually promote, and have synergistic effect, and forming one is beneficial to digesting and assimilating for enteron aisle in human body, effective to solve breast
Sugar does not tolerate symptom, and a better choice is provided for the treatment of lactose intolerance, clinically there is an application well yet
Prospect.
Embodiment
With reference to embodiment, the invention will be further described.
Embodiment 1
The modulation milk powder of the adjustment function of intestinal canal containing lactase of the present embodiment, is made of the component of following parts by weight：Whole milk
Powder 500kg, maltodextrin 34kg, oligofructose 31kg, galactooligosaccharide 31kg, lactase 25kg, bifidobacterium lactis 3.9kg,
Lactobacillus rhamnosus 2.6kg.（The CFU/g of active probiotic additive amount >=2,500,000,000）
Its preparation method, comprises the following steps：
（1）Dispensing：The whole milk with the equal total dry solids weight of whole milk powder in formula is weighed, with maltodextrin, oligomeric fruit
Sugar and galactooligosaccharide squeeze into temporary storage tank after mixing；
（2）Homogeneous：Homogeneous is carried out to material in temporary storage tank under the conditions of temperature 60 C, pressure 20MPa；
（3）Sterilization：It will be sterilized 22 seconds under conditions of 88-92 DEG C of temperature by the mixed liquor of homogeneous；
（4）Concentration：Under the conditions of vacuum -21~-8kPa, 55-65 DEG C of temperature, 19 ° of B é are concentrated into；
（5）Spray drying, by by concentration mixed liquor pressure be 18MPa, feeding inlet air temperature is 175 DEG C, air draft temperature
Spend to be spray-dried under conditions of 80 DEG C；
（6）Cool, room temperature will be cooled down to through fluid bed by dry mixed liquor, in material water content for 2.0~
3.5wt%, then adds bifidobacterium lactis freeze-dried powder and Lactobacillus rhamnosus freeze-dried powder, lactase, is mixed in screw mixer
Close 20 minutes to be uniformly mixed；
（7）Packaging, controlled atmosphere pouch-packaged is carried out using vacuum nitrogen（2g/ bags）, obtain final products Lactase-1 testing results
It is shown in Table 1.
Table 1Lactase-1 testing results
Embodiment 2
The modulation milk powder of the adjustment function of intestinal canal containing lactase of the present embodiment, is made of the component of following parts by weight：It is instant complete
Fat milk powder 500kg, concentrated whey protein powder 34kg, inulin 62kg, lactase 18.8kg, bifidobacterium lactis 3.9kg, rhamnose breast
Bacillus 2.6kg.（The CFU/g of active probiotic additive amount >=2,500,000,000）
Its preparation method, comprises the following steps：
（1）Dispensing：Weigh with formula in the equal total dry solids weight of whole milk powder whole milk, with concentrated whey protein powder and
Inulin squeezes into temporary storage tank after mixing；
（2）Homogeneous：Homogeneous is carried out to material in temporary storage tank under the conditions of temperature 60 C, pressure 20MPa；
（3）Sterilization：It will be sterilized 22 seconds under conditions of 88-92 DEG C of temperature by the mixed liquor of homogeneous；
（4）Concentration：Under the conditions of vacuum -21~-8kPa, 55-65 DEG C of temperature, 19 ° of B é are concentrated into；
（5）Spray drying, by by concentration mixed liquor pressure be 18MPa, feeding inlet air temperature is 175 DEG C, air draft temperature
Spend to be spray-dried under conditions of 80 DEG C；
（6）Cool, room temperature will be cooled down to through fluid bed by dry mixed liquor, water content is 2.0- in material
3.5wt%, then adds bifidobacterium lactis freeze-dried powder and Lactobacillus rhamnosus freeze-dried powder, lactase, is mixed in screw mixer
Close 20 minutes to be uniformly mixed；
（7）Packaging, controlled atmosphere pouch-packaged is carried out using vacuum filling CO 2（2g/ bags）, obtain final products Lactase-2 inspections
Survey the results are shown in Table 2.
2 Lactase-2 testing results of table
Embodiment 3
The modulation milk powder of the adjustment function of intestinal canal containing lactase of the present embodiment, is made of the component of following parts by weight：It is lactose-free
Milk powder 500kg, maltodextrin 80kg, oligofructose 33.3kg, stachyose 33.3kg, lactase 13.4kg, bifidobacterium lactis
4kg, lactobacillus acidophilus 2.7kg.（The CFU/g of active probiotic additive amount >=2,500,000,000）
Its preparation method, comprises the following steps：
（1）Level-one is dry-mixed：Lactose-free milk powder 50kg, bifidobacterium lactis freeze-dried powder, lactobacillus acidophilus freeze-drying powder and lactase is taken to put
Enter in three-dimensional mixer, be uniformly mixed according to operational procedure, material is through two-phase transportation into mixer；
（2）Two level is dry-mixed：By the lactose-free milk powder of predetermined ratio, maltodextrin, oligofructose and stachyose with predetermined ratio
Put into mixer, be uniformly mixed according to operational procedure with the dry-mixed product of level-one, two-phase transportation to packing machine；
（3）Packaging, controlled atmosphere pouch-packaged is carried out using vacuum nitrogen（2g/ bags）, obtain final products Lactase-3, detection knot
Fruit is shown in Table 3.
3 Lactase-3 testing results of table
Above-described embodiment is subjected to test-meal experiment, process is tested and specific evaluating data is as follows：
By above-mentioned 3 embodiments, blank groups（Have milk merely, do not add lactase modulation milk powder product）With diet control group（Examination
Do not had milk in testing）It is divided into 5 experimental groups.
Each test-meal experiment 30 lactose-intolerant persons of group selection, patient confirm as lactose intolerance through urine galactose detection
By, and first 2-3 days edible milk powder, at least occur in abdominal distension, abdominal pain, diarrhea, borborygmus, sour smelly and 6 symptoms of watery stool in oral cavity
2 and more than.
Standard diet is given in experiment for every group, and wherein implementation group gives 250mL milk in two postprandial half an hour sooner or later daily
+ 1 bag of powder solution（2g）Lactase modulates milk powder（+ 1 bag of lactase modulation milk powder+240mL water of about 8 spoonfuls of milk powder, wherein water temperature be not high
In 40 DEG C）；Blank group gives 250mL milk power solutions in two postprandial half an hour sooner or later daily（About 8 spoonfuls of milk powder+240mL water, wherein
Water temperature is not higher than 40 DEG C）；Diet control group does not award the milk power solution of preparation then, does not award yet and modulates milk product containing lactase.
After test-meal 2 days, the improvement situation that observes the symptoms is as shown in the table within the 3rd day：
| Packet | Total number of persons | Have no improvement | Slightly improve | It is obviously improved | Improve completely |
| Blank group | 30 | 24 | 4 | 2 | 0 |
| Embodiment 1 | 30 | 0 | 2 | 8 | 20 |
| Embodiment 2 | 30 | 0 | 6 | 8 | 16 |
| Embodiment 3 | 30 | 0 | 4 | 12 | 14 |
| Diet control group | 30 | 0 | 6 | 14 | 10 |
The lactose intolerance symptom that can be seen that three groups of embodiments and diet control group from above-mentioned test-meal experimental result is changed
It is kind, and it is substantially better than blank group；The symptom improvement of three groups of embodiments is also better than diet control group.
The testing result of bacterium in excrement
Situation (the unit of contained bacterium before and after being tested in the excrement of blank group, embodiment and diet control group：CFU/g)
It can be seen that from above-mentioned test-meal experimental result compared to blank group and diet control group, the bifid bar in embodiment excrement
The quantitative obvious increase of bacterium, lactobacillus, Bacillus perfringens quantitatively significantly reduces, bright into effect to improving human body intestinal canal microorganism group
It is aobvious.
In conclusion the present invention containing lactase adjustment function of intestinal canal modulation milk powder in lactase, probiotics and
Prebiotics can mutually promote, and have synergistic effect, can be obviously improved the lactose intolerances such as abdominal distension, abdominal pain, diarrhea, borborygmus
Shape, adjusts intestinal flora, improves the healthy and unobstructed situation of enteron aisle, have great practical value, clinically also there is one
Good application prospect.
The foregoing is only a preferred embodiment of the present invention, is not intended to limit the invention, for the skill of this area
For art personnel, the present invention can have various similar changes and change, all main nutrients and innovation point range in the present invention
Within any modification, equivalent substitution, improvement and etc. done, should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of modulation milk powder of the adjustment function of intestinal canal containing lactase, it is characterised in that by the raw material of following percentage by weight
It is made：
Milk powder 50-80%, milk proteins raw material and/or carbohydrate raw material 5-30%, prebiotics 5-15%, lactase 1-5%
With probiotics 0.3-1.5%；The sum of described each component percentage by weight is 100%.
2. the modulation milk powder of the adjustment function of intestinal canal according to claim 1 containing lactase, it is characterised in that the lactose
Enzyme refers to the lactase from microbial fermentation extraction：From aspergillus oryzae, aspergillus niger, Kluyveromyces fragilis, newborn Crewe
Tie up yeast and pichia pastoris yeast.
3. the modulation milk powder of the adjustment function of intestinal canal according to claim 1 or 2 containing lactase, it is characterised in that described
Probiotics is one kind in lactobacillus acidophilus, animal bifidobacteria, bifidobacterium lactis, Lactobacillus rhamnosus and lactobacillus reuteri
Or several mixture.
4. the modulation milk powder of the adjustment function of intestinal canal according to claim 1 or 2 containing lactase, it is characterised in that described
Prebiotics for oligofructose, galactooligosaccharide, xylo-oligosaccharide, oligoisomaltose, polydextrose, inulin, human milk oligosaccharides and
One or more of mixtures in stachyose.
5. the modulation milk powder of the adjustment function of intestinal canal according to claim 1 or 2 containing lactase, it is characterised in that described
Milk powder raw material is one or more of mixtures in whole milk powder, skimmed milk power, lactose-free milk powder and fermentation milk powder.
6. the modulation milk powder of the adjustment function of intestinal canal according to claim 1 or 2 containing lactase, it is characterised in that described
Milk proteins raw material is concentrated whey protein powder, milk protein peptides, sepg whey albumen powder, one kind in α-lactalbumin or several
The mixture of kind.
7. the modulation milk powder of the adjustment function of intestinal canal according to claim 1 or 2 containing lactase, it is characterised in that described
Carbohydrate raw material is one or more of mixtures in maltodextrin, starch, corn-syrup solids and glucose.
8. the modulation milk powder of the adjustment function of intestinal canal according to claim 1 or 2 containing lactase, it is characterised in that each
Lactase contained by basic preparation unit is 2000-10000ALU；Probiotics is 1.0 × 108-1.0×1010CFU；It is prebiotic
Member is 0.1-1.5g.
9. a kind of preparation method of the modulation milk powder of the adjustment function of intestinal canal containing lactase as claimed in claim 1, its feature
It is, using wet processing, comprises the following steps：
（1）Dispensing：Milk powder, milk proteins raw material and/or carbohydrate raw material, prebiotics are mixed by predetermined ratio, then
Add water and mix, then squeeze into temporary storage tank；
Or take and the whole milk of the equal dry matter content of milk powder and milk proteins raw material and/or carbohydrate in formula
Raw material, prebiotics squeeze into temporary storage tank after mixing；
（2）Homogeneous：Homogeneous is carried out to material in temporary storage tank under the conditions of 55-65 DEG C of temperature, pressure 15-22MPa；
（3）Sterilization：It will be sterilized 20-25 seconds under the conditions of 85-92 DEG C of temperature by the mixed liquor of homogeneous；
（4）Concentration：Under the conditions of vacuum -21~-8kPa, 55-65 DEG C of temperature, 17-21 ° of B é is concentrated into；
（5）Spray drying：By by concentration mixed liquor pressure be 15-25 MPa, feeding inlet air temperature be 170-210
DEG C, temperature of outgoing air be 80-90 DEG C under conditions of be spray-dried；
（6）Cool：Room temperature will be cooled down to through fluid bed by dry mixed liquor, water content is 2.0- in material
3.5wt%, then adds probiotics and lactase by predetermined ratio, is uniformly mixed in screw mixer；
（7）Packaging, carries out controlled atmosphere pouch-packaged using vacuum nitrogen or carbon dioxide, obtains final products.
10. a kind of preparation method of the modulation milk powder of the adjustment function of intestinal canal containing lactase as claimed in claim 1, its feature
It is, using dry process, comprises the following steps：
（1）Level-one is dry-mixed：Take the milk powder of predetermined ratio 5-15wt%, be put into three-dimensional hybrid with the probiotics of predetermined ratio, lactase
In machine, it is uniformly mixed according to operational procedure, material is through two-phase transportation into mixer；
（2）Two level is dry-mixed：By the remaining milk powder of predetermined ratio, milk proteins raw material and/or carbohydrate with predetermined ratio
In raw material, prebiotics input mixer, it is uniformly mixed according to operational procedure with the dry-mixed product of level-one, two-phase transportation to packing machine；
（3）Packaging, carries out controlled atmosphere pouch-packaged using vacuum nitrogen or carbon dioxide, obtains final products.
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| CN112514996A (en) * | 2019-09-19 | 2021-03-19 | 内蒙古伊利实业集团股份有限公司 | Combination or composition, dairy product and use |
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