CN109757731A - Alleviate the probiotic composition and its preparation method and application of lactose intolerance - Google Patents
Alleviate the probiotic composition and its preparation method and application of lactose intolerance Download PDFInfo
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- CN109757731A CN109757731A CN201910191627.2A CN201910191627A CN109757731A CN 109757731 A CN109757731 A CN 109757731A CN 201910191627 A CN201910191627 A CN 201910191627A CN 109757731 A CN109757731 A CN 109757731A
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- lactose intolerance
- probiotic composition
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Abstract
The present invention provides a kind of probiotic compositions and its preparation method and application for alleviating lactose intolerance.In parts by mass, the probiotic composition includes: 0.1 part -10 parts of Lactobacillus rhamnosus, 0.1 part -10 parts of lactobacillus acidophilus, modulates 5 parts -30 parts of milk powder, 5 parts -40 parts of flavoring agent, 5 parts -120 parts of prebiotics；The Lactobacillus rhamnosus is Lactobacillus rhamnosus GG, and the lactobacillus acidophilus is the combination of lactobacillus acidophilus NCFM, lactobacillus acidophilus DDS-1.The probiotic composition can play good preventive effect to lactose intolerance, i.e., consumer, which takes in the case that the probiotic composition takes in lactase-containing comestibles later again, can be relieved lactose intolerance symptom；And consumer takes in the probiotic composition after intake lactose products cause lactose intolerance symptom again, can improve symptom, i.e., probiotic composition provided by the invention has the double effects for preventing, treating lactose intolerance.
Description
Technical field
The present invention relates to field of functional food, and in particular to a kind of probiotic composition for alleviating lactose intolerance and its
Preparation method and application.
Background technique
For a long time, milk can cause some unpleasant symptoms, such as stomach upset, this is by lactose intolerance or right
Caused by milk protein allergy.For baby, two kinds of adverse reactions can be coexisted.Milk is first that baby touches
Extraneous protein source, while it being also very important source of nutrition, therefore, dairy produce cannot be arranged easily in baby's recipe
It removes.
Data show that nearly eighty per cant population in Asia is perplexed by lactose intolerance, and lactose intolerance crowd can not effectively obtain in milk
Nutrition, or even will appear the adverse reactions such as vomiting, diarrhea.Lactose intolerance is that do not have enough ability digestion quite to count due to human body
The lactose (most important sugar in milk) of amount, the main reason for causing lactose intolerance, are the absence of the lactase secreted by small intestine cells；
Sugar decomposition in milk is absorbed by the blood by lactase at monosaccharide form.When no enough lactose enzymic digestion lactose,
Usually there is no real life dangers, but can make us generating uncomfortable symptom.Universal symptom has nausea, stomach convulsion
Contraction, abdominal distension and diarrhea, 30 minutes to 2 hours after taking the food containing lactose periods usually occur in they.Due to not
Same individual is different to the tolerance level of lactose, and the severity of symptom is also different.
Lactose is a kind of disaccharide, and molecule is made of a molecule glucose and a molecule galactolipin.Lactose is in human body
It cannot directly be absorbed, needing to decompose under the action of lactase can just be absorbed, and the crowd for lacking galantase is taking in
After lactose, undigested lactose is directly entered large intestine, and stimulation intestinal peristalsis is accelerated, and causing the symptoms such as borborygmus, diarrhea is cream
For sugar intolerant to disease, the eating habit and living standard of the symptom and crowd are closely related.China belongs to the high-incidence state of lactose intolerance
Family, children's incidence is especially high, therefore, solves the problems, such as that this has important meaning to the symptom is mitigated.
Currently, the product for lactose intolerance has exploitation, for example, prior art discloses a kind of adjustment containing lactase
Modulation milk powder of function of intestinal canal and preparation method thereof.Milk powder is modulated in the technical solution by following components in percentage by weight group
At: milk powder 50-80%, milk proteins raw material and/or carbohydrate raw material 5-30%, prebiotics 5-15%, lactase 1-
5% and probiotics 0.3-1.5%, wherein prebiotics are oligofructose, galactooligosaccharide, xylo-oligosaccharide, oligoisomaltose, gather
The mixture of one or more of glucose, inulin, human milk oligosaccharides and stachyose, probiotics are lactobacillus acidophilus, animal
The mixture of one or more of Bifidobacterium, bifidobacterium lactis, Lactobacillus rhamnosus and lactobacillus reuteri.But mesh
These preceding products are mainly used for alleviation, improvement, treatment after lactose intolerance symptom occurs, cannot be in the feelings taken in advance
Alleviate lactose intolerance symptom under condition well, consumer, which is difficult to avoid that, to be subjected to because of lactose intolerance bring sense of discomfort.
It would therefore be highly desirable to provide a kind of product of alleviation lactose intolerance with preventive effect.
Summary of the invention
Based on this, the main object of the present invention is to provide a kind of probiotic composition for alleviating lactose intolerance.Consumer's clothes
In the case where taking in again containing lactose products after the probiotic composition, lactose intolerance symptom, and consumer can be alleviated
The probiotic composition is taken in again after intake lactose products cause lactose intolerance symptom, can improve symptom, i.e. the present invention mentions
The probiotic composition of confession has the double effects for preventing, treating lactose intolerance.
The purpose of the present invention is what is be achieved through the following technical solutions:
A kind of probiotic composition for alleviating lactose intolerance, in parts by mass, the probiotic composition includes:
The Lactobacillus rhamnosus is Lactobacillus rhamnosus GG, and the lactobacillus acidophilus is lactobacillus acidophilus NCFM, acidophilus
The combination of lactobacillus DDS-1.
In wherein some embodiments, the probiotic composition includes:
In wherein some embodiments, the probiotic composition includes:
In wherein some embodiments, the prebiotics be galactooligosaccharide, resistant dextrin, oligofructose mass ratio be 1:
(2-8): the mixture of (1-5).
In wherein some embodiments, the flavoring agent selects strawberry powder.
It is a further object of the present invention to provide a kind of preparation method of the probiotic composition of above-mentioned alleviation lactose intolerance,
The preparation method includes:
The modulation milk powder, flavoring agent, prebiotics are taken, dry, sieving is then newborn with the Lactobacillus rhamnosus, acidophilus
Bacillus be uniformly mixed to get.
In wherein some embodiments, the temperature of the drying selects 30 DEG C -100 DEG C, gained modulation cream after the drying
Powder, flavoring agent, prebiotics water content be lower than 7%；The sieving was -100 mesh of 30 mesh.
In wherein some embodiments, the temperature of the drying selects 40 DEG C -80 DEG C, gained modulation cream after the drying
Powder, flavoring agent, prebiotics water content be lower than 5%；The sieving was -80 mesh of 40 mesh.
Another object of the present invention is to provide the above-mentioned probiotic composition of one kind and prevents and treats lactose intolerance in preparation
Application in drug or health food.
In wherein some embodiments, the drug or health food are lozenge or chewable tablets.
In wherein some embodiments, the health food is solid beverage.
A further object of the invention is to provide a kind of prevention and treatment lactose intolerance drug or health food, the drug or
Health food includes above-mentioned probiotic composition.
Compared with prior art, the present invention have it is following the utility model has the advantages that
The present invention selects the specific bacterial strain of Lactobacillus rhamnosus, lactobacillus acidophilus, by itself and modulation milk powder, strawberry powder, benefit
Raw member is mixed together, and forms the probiotic composition of special formulation.The probiotic composition can play lactose intolerance very well
Preventive effect, i.e., consumer takes take in lactase-containing comestibles again after the probiotic composition in the case where can be relieved cream
Sugar is intolerant to symptom (diarrhea, cramp, vomiting, borborygmus, flatulence etc.), and consumer causes cream in intake lactose products
Sugar can improve symptom intolerant to the probiotic composition is taken in after symptom again, i.e., probiotic composition provided by the invention has
Prevent, treat the double effects of lactose intolerance.
Further, the oligofructose in present invention benefit folic acid composition, resistant dextrin, galactooligosaccharide control are being closed
When suitable ratio, the composition is also equipped with the effect of Deliquescence-resistant.
Specific embodiment
It to facilitate the understanding of the present invention, below will be to invention is more fully described.But the present invention can be to be permitted
Mostly different form is realized, however it is not limited to embodiment described herein.On the contrary, purpose of providing these embodiments is makes
It is more thorough and comprehensive to the understanding of the disclosure.
Unless otherwise defined, all technical and scientific terms used herein and belong to technical field of the invention
The normally understood meaning of technical staff is identical.Term as used herein in the specification of the present invention is intended merely to description tool
The purpose of the embodiment of body, it is not intended that in the limitation present invention.Term as used herein "and/or" includes one or more phases
Any and all combinations of the listed item of pass.
Raw materials used and reagent is commercially available common raw material and reagent unless otherwise specified in following embodiment.
Embodiment 1-5
Embodiment 1-5 each provides a kind of probiotic composition and its preparation method and application for alleviating lactose intolerance.
The formula for alleviating the probiotic composition of lactose intolerance is shown in Table 1.
Table 1 (mass parts: g)
The preparation method for alleviating the probiotic composition of lactose intolerance includes the following steps:
(1) then the above-mentioned raw material in addition to Lactobacillus rhamnosus, lactobacillus acidophilus is done under the conditions of 30-100 DEG C respectively
It is dry to be lower than 7% to its moisture content, it crosses 30-100 mesh and obtains screening object；
(2) screening object is mixed with Lactobacillus rhamnosus, lactobacillus acidophilus, the alleviation lactose intolerance being finally prepared
Probiotic composition.
In the embodiment of the present invention, the viable count of Lactobacillus rhamnosus is 1.0 × 108CFU/g-5.0×1010CFU/g, it is thermophilic
The viable count of Lactobacillus lactis (lactobacillus acidophilus NCFM, lactobacillus acidophilus DDS-1 combination) is 1.0 × 108CFU/g-5.0×
1010CFU/g.It is more advantageous to probiotics and plays the best use, alleviate lactose intolerance, protect gut barrier.
The preparation method for alleviating the probiotic composition of lactose intolerance is simple, easy to operate, is suitble to industrialized production.
Probiotic composition provided by the invention may be used as alleviating the drug or health food of lactose intolerance.It can manage
Solution, perhaps health food can be lozenge, chewable tablets or solid beverage and is being prepared into drug or guarantor these drugs
When health food, auxiliary material, such as sweetener, antioxidant etc. can be suitably added.
Comparative example 1-3
Comparative example 1-3 is the comparative example of embodiment 1 respectively, relative to embodiment 1 main difference is that composition of raw materials not
Together.The composition of raw materials of comparative example 1-3 is shown in Table 2.
Table 2
Effect assessment, intervention effect of the probiotic composition to lactose intolerance for alleviating lactose intolerance
The first, preventive effect
(1) Subject Population is grouped
18 to 65 years old healthy volunteers have been recruited in the research, they have lactose intolerance.Screening access swashs including lactose
Hair access, to be confirmed after lactose excitation based on 10 or higher score to the qualification of the subjective evaluation of following symptom: diarrhea,
Cramp, vomiting, gurgling sound, flatulence and whole symptom.The lactose (being equivalent to 480 milliliters of milk) of 25 grams of every dosage is used
In this research, because it can more reflect the Average milk amount of population consuming.Qualified subject's participation both arms cross-over design, 4 weeks
Intervene, there is 2 weeks phase buffers during intersection.The data of collection include subjective symptom scoring relevant to lactose intolerance.
The crowd for having lactose intolerance for 18 years old to 65 years old is chosen, Subject Population is grouped at random:
Placebo: maltodextrin is given daily.
Experimental group: tested to give the probiotic composition of the alleviation lactose intolerance in embodiment 1-6 and comparative example 1-3
Person, everyone takes 2g daily, continuously takes 4 weeks.
Object of this investigation is to determine the effect of probiotic composition of the present invention prevents the symptom for providing lactose intolerance.
Main purpose is the variation of 6 hours symptom scores of baseline after being excited by lactose, comparative studies product and placebo to prevention cream
Influence of the sugar intolerant to symptom.Research symptom includes diarrhea, cramp, vomiting, gurgling sound, flatulence and whole symptom.Make
With from 0 (asymptomatic) to the severity of 11 subscales of 10 (most serious symptoms) assessment symptom.
(2) Subject Population's lactose provocative test data
Subject takes embodiment, comparative example and after placebo samples 4 week, carries out lactose challenge test, and subject is wanted
Ask record lactose provocative test when starting (the 0th hour) and at the end of the diarrhea of (the 6th hour), cramp, vomiting, borborygmus,
Flatulence and TOP SCORES.The diarrhea of subject and the scoring situation of cramp are as shown in table 3, the vomiting of subject and intestines
The scoring situation of ring is as shown in table 4, and the flatulence of subject and the scoring situation of TOP SCORES are as shown in table 5.
Table 3
Table 4
Table 5
From table 3, table 4, table 5:
(1) comparing embodiment and comparative example, subject of the embodiment 1 into embodiment 5 is 6 after receiving lactose excitation experiment
The variation for diarrhea, cramp, vomiting, borborygmus, flatulence and TOP SCORES of hour is than comparative example 2 to comparative example
3 groups low with placebo, this illustrates that the probiotic combinations composition formula of offer of the invention can be good at alleviating subject's intake
Diarrhea, cramp, vomiting, borborygmus, flatulence after lactose by lactose intolerance initiation.
Also illustrate simultaneously, is combined if changing bacterial strain in probiotic composition of the present invention, it will be to lactose intolerance
The alleviation of symptom has a adverse impact, this illustrate the selections of probiotics strain and prebiotics for the application effect realization extremely
It closes important.
(2) more each embodiment, embodiment 1, embodiment 2, embodiment 3 are better than the remission effect of lactose intolerance symptom
Embodiment 4, embodiment 5, wherein the numerical value in embodiment 3 presents relative to embodiment 1, embodiment 2 with control group more significant
Difference (P < 0.05), this explanation, for probiotic formulation of the invention, there are preferred schemes.
The second, therapeutic effect
(1) Subject Population is grouped: with embodiment 1.
(2) Subject Population's lactose provocative test data
Subject first carries out lactose excitation and generates lactose intolerance symptom, then takes embodiment, comparative example and placebo samples,
Then the improvement of each group lactose intolerance symptom is counted.As a result it see the table below.
The result shows that relative to comparative example product, placebo is taken, subject takes again after there is lactose intolerance symptom
With probiotic composition of the invention, symptom can be improved very well, illustrate probiotic composition of the invention for lactose intolerance
With good therapeutic effect.
Table 6
According to table 6 it is found that relative to the probiotic composition using comparative example 2 and comparative example 3, subject is generating lactose
Intervened intolerant to after symptom in the probiotic composition provided with embodiment 1 to embodiment 5, it also can be to lactose intolerance
Shape plays good relaxation effect, i.e., probiotic composition provided by the present application also has the therapeutic effect of lactose intolerance.
Third improves moisture absorption
(1) experimental group: embodiment 1 to 5 each 3 parts of parallel samples of embodiment, comparative example 1 to 3 each 3 parts of Duplicate Samples of comparative example
Product are encapsulated using aluminium foil bag.
(2) moisture absorption is tested
Embodiment 1 is to embodiment 5, and comparative example 1 is to 3 each 3 parts of comparative example, and totally 24 parts of parallel samples, survey initial water activity；It
Afterwards after 37 DEG C of temperature, the accelerating chamber that ambient humidity is 75% are placed 1 month, takes out sample and survey water activity.It counts at high humility
The variation of reason front and back sample water activity, as a result see the table below.
Table 7
Deliquescence-resistant performance is vital for the storage time limit of probiotic composition, storage quality, workability.
With preferable Deliquescence-resistant performance, it is able to extend the shelf life of probiotic composition, and the prevented from caking, mildew in storage,
Loose dispersity is kept to be easier to subsequent processing.
For the embodiment of the present application 1 into embodiment 5, the prebiotics of use are galactooligosaccharide, resistant dextrin, oligofructose matter
Amount is than being 1:(2-8): the mixture of (1-5), as a result, these probiotic compositions are not easy to be deliquesced in high humidity environment.It is right
Ratio 1 is relative to embodiment 1, although the type and gross mass of addition prebiotics are identical, oligomeric gala contained by comparative example 1
Sugar, resistant dextrin, oligofructose mass ratio have exceeded 1:(2-8): the restriction of (1-5), Comparative result example 1 are more vulnerable to moist ring
The influence in border.The Deliquescence-resistant performance of the application probiotic composition is extremely closed in type and the ratio control of this explanation, prebiotics
It is important.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (10)
1. a kind of probiotic composition for alleviating lactose intolerance, which is characterized in that in parts by mass, the probiotic composition packet
It includes:
The Lactobacillus rhamnosus is Lactobacillus rhamnosus GG, and the lactobacillus acidophilus is lactobacillus acidophilus NCFM, acidophilus cream bar
The combination of bacterium DDS-1.
2. the probiotic composition according to claim 1 for alleviating lactose intolerance, which is characterized in that the probiotic combinations
Object includes:
3. the probiotic composition according to claim 2 for alleviating lactose intolerance, which is characterized in that the probiotic combinations
Object includes:
4. the probiotic composition according to any one of claims 1 to 3 for alleviating lactose intolerance, which is characterized in that described
Prebiotics be galactooligosaccharide, resistant dextrin, oligofructose mass ratio be 1:(2-8): the mixture of (1-5).
5. the preparation method of the described in any item probiotic compositions for alleviating lactose intolerance of Claims 1-4, feature exist
In the preparation method includes:
Take the modulation milk powder, flavoring agent, prebiotics, dry, sieving, then with the Lactobacillus rhamnosus, lactobacillus acidophilus
Be uniformly mixed to get.
6. the preparation method of the probiotic composition according to claim 5 for alleviating lactose intolerance, which is characterized in that described
Dry temperature selects 30 DEG C -100 DEG C, and the water content of gained modulation milk powder, flavoring agent, prebiotics is lower than 7% after the drying；
The sieving was -100 mesh of 30 mesh.
7. the described in any item probiotic compositions of Claims 1-4 are in preparation prevention and treatment lactose intolerance drug or health food
Application.
8. according to application described in right 7, which is characterized in that the drug or health food is lozenge or chewable tablets.
9. according to application described in right 7, which is characterized in that the health food is solid beverage.
10. a kind of prevention and treatment lactose intolerance drug or health food, which is characterized in that the drug or health food are comprising having the right
It is required that 1 to 4 described in any item probiotic compositions.
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Application publication date: 20190517 |