CN107849002A - 一种线叶旋覆花内酯a衍生物 - Google Patents

一种线叶旋覆花内酯a衍生物 Download PDF

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CN107849002A
CN107849002A CN201680028895.7A CN201680028895A CN107849002A CN 107849002 A CN107849002 A CN 107849002A CN 201680028895 A CN201680028895 A CN 201680028895A CN 107849002 A CN107849002 A CN 107849002A
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acid
acetyl group
dimethyl amine
inula lineariifolia
compound
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CN107849002B (zh
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张卫东
孙青龑
李明花
杨保华
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Shanxi Zhendong Leading Biotechnology Co ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
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  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
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Abstract

一种线叶旋覆花内酯A衍生物，尤其是二甲基胺4‑O‑乙酰基线叶旋覆花内酯A或其盐及其制备与在制备治疗多发性硬化症药物中的应用。二甲基胺4‑O‑乙酰基线叶旋覆花内酯A化合物，如式Ⅰ所示：

Description

PCT国内申请，说明书已公开。

Claims (19)

  1. PCT国内申请，权利要求书已公开。
CN201680028895.7A 2015-08-31 2016-08-31 一种线叶旋覆花内酯a衍生物 Active CN107849002B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2015105493279 2015-08-31
CN201510549327.9A CN106478570B (zh) 2015-08-31 2015-08-31 二甲基胺4-o-乙酰基线叶旋覆花内酯a或其盐及其制备与应用
PCT/CN2016/097481 WO2017036392A1 (zh) 2015-08-31 2016-08-31 一种线叶旋覆花内酯a衍生物

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CN107849002A true CN107849002A (zh) 2018-03-27
CN107849002B CN107849002B (zh) 2021-07-06

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CN201680028895.7A Active CN107849002B (zh) 2015-08-31 2016-08-31 一种线叶旋覆花内酯a衍生物

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US (1) US10273220B2 (zh)
EP (1) EP3345896A4 (zh)
CN (2) CN106478570B (zh)
WO (1) WO2017036392A1 (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106478570B (zh) * 2015-08-31 2019-04-05 山西振东先导生物科技有限公司 二甲基胺4-o-乙酰基线叶旋覆花内酯a或其盐及其制备与应用
CN109793731A (zh) * 2017-11-17 2019-05-24 山西振东先导生物科技有限公司 二甲基胺4-o-乙酰基线叶旋覆花内酯a及其盐在制备预防/治疗慢阻肺药物中的应用
CN108864015A (zh) * 2018-08-28 2018-11-23 青海大学 一种具有治疗神经退行性疾病功效的化合物及药物组合物
CN113398117B (zh) * 2021-06-02 2023-08-08 山西振东先导生物科技有限公司 二甲基胺4-o-乙酰基线叶旋覆花内酯a及其盐在制备治疗慢性肾衰竭药物中的应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101830875A (zh) * 2010-06-13 2010-09-15 上海交通大学 抗炎化合物线叶旋覆花内酯a及其制备方法和应用
CN102406637A (zh) * 2011-11-15 2012-04-11 中国人民解放军第二军医大学 双旋覆花内酯甲在制备肿瘤坏死因子抑制剂药物中的应用
CN102727485A (zh) * 2012-06-21 2012-10-17 中国人民解放军第二军医大学 线叶旋覆花内酯a在制备治疗多发性硬化症药物中的应用
CN102727486A (zh) * 2012-06-21 2012-10-17 中国人民解放军第二军医大学 线叶旋覆花内酯a在制备治疗心肌炎药物中的应用
CN106478570B (zh) * 2015-08-31 2019-04-05 山西振东先导生物科技有限公司 二甲基胺4-o-乙酰基线叶旋覆花内酯a或其盐及其制备与应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1034138A (zh) * 1988-11-23 1989-07-26 云南省肿瘤研究所 由旋复花制备抗癌药物的方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101830875A (zh) * 2010-06-13 2010-09-15 上海交通大学 抗炎化合物线叶旋覆花内酯a及其制备方法和应用
CN102406637A (zh) * 2011-11-15 2012-04-11 中国人民解放军第二军医大学 双旋覆花内酯甲在制备肿瘤坏死因子抑制剂药物中的应用
CN102727485A (zh) * 2012-06-21 2012-10-17 中国人民解放军第二军医大学 线叶旋覆花内酯a在制备治疗多发性硬化症药物中的应用
CN102727486A (zh) * 2012-06-21 2012-10-17 中国人民解放军第二军医大学 线叶旋覆花内酯a在制备治疗心肌炎药物中的应用
CN106478570B (zh) * 2015-08-31 2019-04-05 山西振东先导生物科技有限公司 二甲基胺4-o-乙酰基线叶旋覆花内酯a或其盐及其制备与应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HERZ，W等: "Constituents of helenium species—XVI : The structures of flexuosin a and flexuosin B.", 《TETRAHEDRON》 *

Also Published As

Publication number Publication date
US20180251440A1 (en) 2018-09-06
EP3345896A4 (en) 2019-01-09
CN106478570A (zh) 2017-03-08
CN107849002B (zh) 2021-07-06
CN106478570B (zh) 2019-04-05
WO2017036392A1 (zh) 2017-03-09
US10273220B2 (en) 2019-04-30
EP3345896A1 (en) 2018-07-11

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