CN107809995A - 形成用于化妆品应用的具有交联涂层的颗粒的方法 - Google Patents
形成用于化妆品应用的具有交联涂层的颗粒的方法 Download PDFInfo
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- CN107809995A CN107809995A CN201680038682.2A CN201680038682A CN107809995A CN 107809995 A CN107809995 A CN 107809995A CN 201680038682 A CN201680038682 A CN 201680038682A CN 107809995 A CN107809995 A CN 107809995A
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Abstract
本发明涉及一种形成经涂布颗粒的方法，其包括以下步骤：搅拌一定体积的核颗粒，同时加热至约40℃的恒定平均温度。一旦将颗粒大致均匀地混合，而没有明显的附聚，则在连续的螺旋桨式混合下将乙烯基官能的有机硅聚合物、氢化物官能的交联剂和金属催化剂组合到预混物中。然后将乙烯基官能的有机硅聚合物、氢化物官能的交联剂和金属催化剂预混物以确保颗粒物不结团或附聚的速率虹吸到含有加热的核颗粒的主容器中。一旦已经获得均匀涂层，则将主容器加热至约80℃的平均温度，然后冷却回到室温（约20℃‑28℃）。然后使经涂布的材料通过45微米的筛子以去除任何可能存在的大颗粒物。
Description
发明领域
本发明涉及包含用于防止彩色颗粒渗色和/或在溶剂体系中提供颗粒稳定性的经涂布颗粒的局部组合物及其制备方法。
发明背景
化妆品组合物或局部组合物通常包含一种或多种颗粒物组分，例如颜料或染料、填料、增稠剂、防晒剂等。这样的颗粒物组分通常不溶于相应的溶剂或载体体系，并且如果是这样的话则保持分散或悬浮在化妆品组合物或局部组合物中。
合适的颗粒物组分的选单受限于诸如稳定性、与其它化妆品组分的不相容性、皮肤过敏性、反应性等因素。在彩色化妆品的情况下，许多可溶于油或极性溶剂（例如水）的颜料和/或染料可能因“渗色”到更大范围的组合物中而受损。
此外，每当周围环境中的pH和温度发生变化时，分散或悬浮的颗粒可能彼此附聚并从组合物中沉淀出来。粒度越小，活性表面积越大，并且这样的颗粒物组分越容易受到与化妆品组合物或局部组合物中的其它成分或组分的不利相互作用或其干扰的影响，这可能使化妆品组合物或局部组合物不稳定或者降低其整体性能。
用于颗粒的涂层是众所周知的，但是它们通常受制于一个或多个缺点，例如渗透性、不透明性、溶解性和附聚。
因此，一直需要处理或改性化妆品颗粒以消除或减轻上述缺点。还需要改善化妆品组合物中颗粒的整体稳定性和彩色外观，而不会不利地影响颗粒的化学性质和物理性质。
发明概述
在一个方面，本发明涉及局部组合物，其包含经涂布颗粒在化妆品或药学上可接受的载体中的分散体，其中一个或多个核颗粒包含可热固化的涂层，所述可热固化的涂层是乙烯基官能的有机硅聚合物、氢化物官能的交联剂和金属催化剂的反应产物。
另一方面，本发明涉及一种形成经涂布颗粒的方法，其包括以下步骤：
1）搅拌一定体积的核颗粒，同时加热至约40℃的恒定平均温度。
2）一旦将颗粒大致均匀地混合，而没有明显的附聚，则在连续的螺旋桨式混合下将乙烯基官能的有机硅聚合物、氢化物官能的交联剂和金属催化剂组合到预混物中。
3）然后将乙烯基官能的有机硅聚合物、氢化物官能的交联剂和金属催化剂预混物以确保颗粒物不结团（clumping）或附聚的速率虹吸到含有加热的核颗粒的主容器中。
4）一旦已经获得均匀涂层，则将主容器加热至约80℃的平均温度，然后冷却回到室温（约20℃-28℃）。
5）然后使经涂布的材料通过45微米的筛子以去除任何可能存在的大颗粒物。
最终的经涂布颗粒在本文中通常被称为“金属催化的热固化物（thermal cure）”。如将要讨论的，铂（Pt）是特别优选的催化剂。因此，经涂布颗粒也可以被称为“Pt催化的热固化物”。然而，这样的指称不应被解释为限制性的。
本发明的其它方面和目的将从随后的描述、实施例和权利要求中变得更加明显。
发明详述
乙烯基有机硅涂层
本文中的组合物包含涂布有可热固化的有机硅组合物的颗粒。
本文中的乙烯基有机硅涂层含有含乙烯基的聚二有机基硅氧烷基础聚合物，其通常由具有取代基的硅氧烷单元组成，所述取代基包括具有至多约8个碳原子的低级烷基，如甲基、乙基、丙基、异丙基等和约2至20个碳原子的一价烯基，如乙烯基、烯丙基、丁烯基等，包括环烯基。这些聚合物通过本领域已知的方法制备，并且可以以不同的官能度商购获得。它们通常具有在25℃下约50至约100,000厘泊的粘度。
乙烯基有机硅涂层还包含用作交联剂的含SiH的聚硅氧烷。在乙烯基官能的聚硅氧烷基础聚合物和含SiH的交联剂之间发生的固化反应是加成固化反应，称为硅氢化。可以通过基础聚合物的乙烯基和交联剂的SiH反应位点之间的铂族金属催化的交联反应使涂层热固化。
美国专利号5,223,344中提供了示例性的聚二有机基硅氧烷基础聚合物和含SiH的聚硅氧烷。
合适的硅氢化催化剂是已知的，并且包括使用诸如钌、铑、钯、锇、铱和铂之类的贵金属以及这些金属的配合物的铂族金属催化剂。优选的是铂金属催化剂。此类硅氢化催化剂的实例尤其描述于Lamoreaux，美国专利号3,220,972；Karstedt，美国专利号3,715,334；3,775,452和3,814,730；Ashby，美国专利号4,421,903；和4,288,345；和Saruyama等人，美国专利号5,057,476中。
具体催化剂的选择将取决于诸如所需反应速度、费用、有用的贮存期（shelf-life）、有用的适用期以及在其下发生固化反应的温度等因素。只要实现适当的交联，所用的催化剂的量并非是关键的；然而，如上所述，这些贵金属催化剂的高成本使得必须保守使用它们。与任何催化剂一样，优选使用可能的最小有效量，对于本文中所述的涂层组合物而言，使用足够的总催化剂来提供以贵金属计约5至约500份每百万份的贵金属。
在一个实施方案中，涂层可以包含硅烷固化促进剂添加剂。本发明的硅烷添加剂是具有至少两个与硅原子键合的氢原子的那些。优选的是具有通式R2 2SiH2和R2SiH3的那些，其中R2选自烷基；卤素，如氯、溴和碘；环烷基和苯基。
典型地，硅烷固化促进剂添加剂选自硅烷，例如但不限于：二氯硅烷、二甲基硅烷、二乙基硅烷、二丙基硅烷、二丁基硅烷、二戊基硅烷、二己基硅烷、二庚基硅烷、二辛基硅烷、二壬基硅烷、二癸基硅烷、二环戊基硅烷、二环己基硅烷、二环庚基硅烷、二苯基硅烷、苯基氯硅烷、苯基乙基硅烷、甲基辛基硅烷、甲基癸基硅烷、苯基甲基硅烷、苯基乙基硅烷、苯基环己基硅烷和甲基环庚基硅烷。优选的是二苯基硅烷、苯基硅烷、二辛基硅烷、甲基癸基硅烷、苯基甲基硅烷和二癸基硅烷。最优选的是二苯基硅烷和苯基硅烷。
硅烷固化促进剂添加剂以小的有效量使用。典型地，硅烷固化促进剂添加剂以约0.25至约20的硅烷摩尔数比催化剂金属摩尔数，最优选约0.5至约5的硅烷摩尔数比催化剂金属摩尔数的量存在于本发明的组合物中。
该组合物还可以包含抑制剂。这些用于防止单包装（one-package）体系中的过早固化，并且还延长储存产品的贮存期和使用中产品的适用期。也就是说，在室温下，整个有机硅组合物不会过早地胶凝，这在使用催化的有机硅组合物的情况下经常发生。特别有用的是羧酸二烷基酯和羧酸二烯基酯抑制剂，如马来酸二烯丙酯和马来酸二甲酯。这些对于本领域技术人员而言是已知的，并且描述于美国专利号4,256,870中。
另外的抑制剂包括但不限于：炔醇，例如在美国专利号3,445,420中描述的那些；胺，例如在美国专利号4,584,361中描述的那些；异氰脲酸酯，例如在美国专利号3,882,083中描述的那些；烯-炔，例如在美国专利号4,465,818中描述的那些；乙酸乙烯酯，例如在美国专利号4,476,166中描述的那些；和乙炔二羧酸酯，例如在美国专利号4,347,346中描述的那些。
可以向组合物中添加另外的成分以赋予特定的性质，并使组合物适合最终用户的需求。例如，根据需要，组合物可以分散在溶剂中或以100%固体制剂的形式使用。
可以将乙烯基生胶固化促进剂（例如在Eckberg，美国专利号Re. 31,727中描述的那些）加入到本发明的组合物中。基于基础聚合物的总重量计，添加约0.5至约10重量％的乙烯基生胶减少了所需的固化时间。
本公开还预期其它的常规添加剂，例如本领域技术人员所熟知的控释添加剂（“CRA”）、抗微生物剂、消泡剂和其它添加剂。
也可以添加填料和添加剂以改善热稳定性、耐候性、耐化学性、阻燃性或机械强度或者降低气体渗透程度。这些填料和添加剂的实例包括热解法二氧化硅、石英粉、玻璃纤维、炭黑、氧化铝、金属氧化物（如氧化铁和氧化钛）以及金属碳酸盐（如碳酸钙和碳酸镁）。此外，可以在不干扰固化过程的范围内添加合适的颜料、染料、发泡剂或抗氧化剂。
乙烯基有机硅涂布方法
用于涂布颗粒物材料的方法是众所周知的。然而，本文中的Pt催化的热固化物是用通常施加到大的、通常平坦的表面上的涂层材料形成的。本发明已适应用于涂布大的表面以使涂布的颗粒物具有小于约45微米的平均粒度的热固化方法。如下提供形成Pt催化的热固化物的步骤：
1）搅拌一定体积的核颗粒，同时加热至约40℃的恒定平均温度。用于工业应用的常规最大体积为约22升，在例如Littleford Model M-5实验室混合机中。
2）一旦将颗粒大致均匀地混合，而没有明显的附聚，则在连续螺旋桨式混合下将乙烯基官能的有机硅聚合物、氢化物官能的交联剂和铂催化剂组合到预混物中。
3）然后将乙烯基官能的有机硅聚合物、氢化物官能的交联剂和铂催化剂预混物以确保颗粒物不结团或附聚的速率虹吸到含有加热的核颗粒的主容器中。
4）一旦已经获得均匀涂层，则将主容器加热至约80℃的平均温度，然后冷却回到室温（约20℃-28℃）。
5）然后使经涂布的材料通过45微米的筛子以去除任何可能存在的大颗粒物。
由前述方法得到的经涂布的颗粒物材料被称为“Pt催化的热固化物”。Pt催化的热固化物对于经由其交联涂层密封颗粒物表面而言特别有用。因此，各种各样的化妆品颗粒物材料（其否则将会“渗色”到化妆品组合物中）能够用于化妆品配方中。常规的核颗粒以及否则易于渗色的那些由此可用作Pt催化的热固化物的组分。下面详细描述这样的示例性核颗粒。
化妆品核颗粒
本发明提供可用于化妆品组合物或局部组合物中的经涂布的颗粒物组分，以及制备此类经涂布的颗粒物组分的方法。具体而言，经涂布的颗粒各自包含至少一个核颗粒，其优选为不溶于相应的溶剂体系（水性体系或无水体系）的固体颗粒，其涂布有本文中的乙烯基有机硅离型涂层。
可用于本发明的核颗粒可以是常用于化妆品组合物或药物组合物中的任何颗粒物组分，其包括但不限于：矿物颜料和填料，例如滑石、高岭土、云母，氯氧化铋、氢氧化铬、硫酸钡、聚甲基丙烯酸甲酯（PMMA）、氮化硼、尼龙珠粒、聚合物粉末（例如，由六亚甲基二异氰酸酯/三羟甲基己基内酯交联聚合物和二氧化硅组成的BPD 500粉末，其可商购自KoboProducts, Inc. at South Plainfield, NJ）、二氧化硅、二氧化硅珠粒、色淀（例如铝或钙色淀）、金属氧化物（例如黑色氧化铁、黄色氧化铁或蓝色氧化铁、氧化铬、氧化锌和二氧化钛）、物理和化学防晒剂、以及任何其它有机和无机粉末或颗粒。
在一个实施方案中，核颗粒可以是染料或颜料。优选地，染料或颜料可以是水溶性的。在一个具体的实施方案中，颜料可以是水溶性生物颜料，例如花色素苷类或甜菜碱类。
核颗粒可以具有任何规则或不规则的形状，例如球形、立方形、圆柱形、平面形、纤维状、层状等。用于本发明的核颗粒的平均粒度优选为约0.1微米至约50微米、更优选约0.25微米至约25微米、最优选约0.45微米至约9微米。核颗粒优选构成经涂布颗粒的总重量的约10％至约99％，更优选构成经涂布颗粒的总重量的约40％至90％。
染料
根据本公开的至少一个实施方案，组合物可以包含至少一种染料。
出于本公开的目的，术语“染料”是指当其在适当的化妆品介质中以足够的量配制时能够产生彩色光学效应的化合物。
在至少一个实施方案中，所述至少一种染料选自颜料、珍珠母、薄片染料（flakes）、脂溶性染料和水溶性染料、及其混合物。
在本公开中，术语“颜料”应当理解为是指不溶于液体有机相并意在使组合物着色和/或不透明的白色或彩色的无机或有机颗粒。
如本公开中所用的术语“珍珠母”应当理解为是指虹彩颗粒，其例如由某些软体动物在它们的壳中产生或以其它方式合成，其不溶于组合物的介质中。
在本公开的上下文中，术语“染料”应当理解为通常是指可溶于脂肪物质（如油）或可溶于水相中的有机化合物。
在至少一个实施方案中，所述至少一种染料以相对于组合物的总重量计0.01重量％至40重量％，例如5重量％至30重量％或5重量％至20重量％的量存在。
根据本公开的至少一个实施方案，所述至少一种染料包含至少一种颜料。
所述至少一种颜料可以选自无机颜料、有机颜料和复合颜料（即基于无机材料和/或有机材料的颜料）。
在本公开中，术语“颜料”应当理解为是指具有光学效应的任何形式的矿物颗粒或合成颗粒，其不溶于组合物的介质中，不管制造组合物的温度如何。
所述至少一种颜料可以选自例如单色颜料、色淀、珍珠母和具有光学效应的颜料，例如反射性颜料和角异色性颜料。
在至少一个实施方案中，矿物颜料选自金属氧化物颜料、涂布有二氧化钛的云母、涂布有氯氧化铋的云母、涂布有氧化铁的钛云母、涂布有铁蓝的钛云母、涂布有氧化铬的钛云母、氧化铁、二氧化钛、氧化锌、氧化铈、氧化锆或氧化铬；锰紫、普鲁士蓝、群青蓝、铁蓝、氯氧化铋、彩色珠光颜料，如带有氧化铁的钛云母、带有例如铁蓝或氧化铬的钛云母、带有上述类型的有机颜料的钛云母、和基于氯氧化铋的珠光颜料、以及它们的混合物。
有机颜料可以包括，例如：胭脂虫红；偶氮染料、蒽醌染料、靛类染料、呫吨类染料、芘类染料、喹啉类染料、三苯甲烷类染料或荧烷染料的有机颜料；钠、钾、钙、钡、铝、锆、锶或钛的有机色淀或不溶性盐，或者例如偶氮染料、蒽醌染料、靛类染料、呫吨类染料、芘类染料、喹啉类染料、三苯甲烷类染料或荧烷染料的酸性染料。这些染料可以包含至少一个羧酸或磺酸基团；和黑色素颜料。
在根据本公开可以使用的有机颜料中，可以非限制性地提及D&C Blue No 4、D&CBrown No 1、D&C Green No 5、D&C Green No 6、D&C Orange No 4、D&C Orange No 5、D&COrange No 10、D&C Orange No 11、D&C Red No 6、D&C Red No 7、D&C Red No 17、D&C RedNo 21、D&C Red No 22、D&C Red No 27、D&C Red No 28、D&C Red No 30、D&C Red No 31、D&C Red No 33、D&C Red No 34、D&C Red No 36、D&C Violet No 2、D&C Yellow No 7、D&CYellow No 8、D&C Yellow No 10、D&C Yellow No 11、FD&C Blue No 1、FD&C Green No 3、FD&C Red No 40、FD&C Yellow No 5和FD&C Yellow No 6。
根据至少一个实施方案，存在于根据本公开的组合物中的至少一种颜料选自疏水性涂布的颜料。
在本公开的上下文中，术语“疏水性涂布的颜料”是指用疏水剂表面处理以使其与乳液的脂肪相相容的颜料，由此它们可以显示出与脂肪相的油的良好的可润湿性。这些处理过的颜料可以充分地分散在脂肪相中。
意在涂布的颜料可以是上述的无机颜料或有机颜料。
在至少一个实施方案中，使用氧化铁或二氧化钛颜料。
疏水性处理剂可以选自有机硅，例如聚甲基硅氧烷（methicones）、聚二甲基硅氧烷（dimethicones）或全氟烷基硅烷；脂肪酸，例如硬脂酸；金属皂，例如二肉豆蔻酸铝、氢化牛油谷氨酸铝盐、全氟烷基磷酸酯、全氟烷基硅烷、全氟烷基硅氮烷、聚六氟环氧丙烷、包含全氟烷基全氟聚醚基团的聚有机基硅氧烷、和氨基酸；N-酰基氨基酸或其盐；卵磷脂、三异硬酯酸钛酸异丙酯，以及它们的混合物。
N-酰基氨基酸可以包含含有8至22个碳原子的酰基，例如2-乙基己酰基、己酰基、月桂酰基、肉豆蔻酰基、棕榈酰基、硬脂酰基或椰油酰基。这些化合物的盐可以是铝盐、镁盐、钙盐、锆盐、锌盐、钠盐或钾盐。氨基酸可以是例如赖氨酸、谷氨酸或丙氨酸。
在本公开中，上述化合物中提及的术语“烷基”可以表示包含1至30个碳原子，例如5至16个碳原子的烷基。
经疏水性处理的颜料描述在例如欧洲专利申请号EP-A-1 086 683中。虽然此类颜料可以进一步用本文中的涂层来涂布，但是本发明的涂层可能优于传统的疏水性涂层处理。例如许多有机硅涂层带有固有的着色，这可能会干扰任何核颗粒的颜色展示。但是本文中的涂层是基本上透明无色的，因此经涂布核颗粒相比于经疏水性处理的颗粒具有更高的传递颜色的效率。
颜料可以以相对于组合物的总重量计2重量％至40重量％，例如5重量％至30重量％或5重量％至20重量％的量存在于根据本公开的至少一个实施方案的组合物中。
脂溶性染料可选自例如苏丹红、D&C Red No. 17、D&C Green No. 6，β-胡萝卜素、大豆油、苏丹棕、D&C Yellow No. 11、D&C Violet No. 2、D&C Orange No. 5、喹啉黄、胭脂树橙和溴代酸。
水溶性染料可以选自例如甜菜根汁、亚甲基蓝和焦糖色素（caramel）。当配制成局部组合物时，本发明的经涂布颗粒提供了各种优点和益处，这些优点和益处在其未包封的或“裸露的”对应物中是不可获得的。例如，由于核颗粒被涂层密封而得以避开局部组合物中的潜在去稳定或降解活性成分，所以它们比其未包封的或“裸露的”对应物更稳定。此外，如果核颗粒含有可能导致产生反应性氧物类（ROS）的一种或多种材料（所述反应性氧物类可能转而降解或以其它方式干扰局部组合物中的其它活性成分），则抗氧化剂涂层起到清除ROS并由此减少干扰或降解并且改善局部组合物的整体稳定性的作用。通过疏水性的N-酰基氨基酸的水不溶性金属盐涂布核颗粒也可以将疏水性赋予本质上是亲水性的某些核颗粒，并允许这样的核颗粒配制到与未包封的或“裸露的”亲水性颗粒不相容的油相或硅油相中。重要的是要注意，核颗粒的所需化学性质和/或物理性质应保持基本上不受上述涂层存在的影响。
可以将经涂布颗粒直接加入到任何药学或化妆品可接受的载体中以形成化妆品组合物或局部组合物。出于本发明的目的，药学或化妆品可接受的载体是与人类皮肤生物相容的物质，并且可用于将上文和/或下文所述的活性成分配制成可局部施用的乳霜、凝胶、乳液、液体、悬浮液、粉末、粉底、指甲油（nail coating）、唇部处理、睫毛膏、润肤油或乳剂。在化妆品可接受的载体为乳液形式的情况下，其可含有总组合物的约0.1-99重量％、优选约0.5-95重量％、更优选约1-80重量％的水以及总组合物的约0.1-99重量％、优选约0.1-80重量％、更优选约0.5-75重量％的油。如果组合物是无水的，则其可包含约0.1-90重量％的油和约0.1-75重量％的其它成分，例如颜料、粉末、非水性溶剂（例如单醇、二醇或多元醇等）。在组合物为水基凝胶、溶液或悬浮液形式的情况下，其可包含约0.1-99重量％的水和约0.1-75重量％的其它成分，例如植物药、非水溶剂等。
一种或多种药学或化妆品可接受的载体可以以按局部组合物或化妆品组合物的总重量计约0.1％至约99.9％、优选约5％至约99.5％、更优选约10％至约99％、最优选约10％至90％的量存在于本发明的局部组合物或化妆品组合物中。
局部组合物或化妆品组合物可含有一种或多种护肤活性物，其是对皮肤提供益处，而不仅仅是改善局部组合物的物理特性或美学特性的试剂。如果存在的话，这样的护肤活性物可以占总组合物的约0.01-50重量％、优选约0.05-35重量％。可用于本发明的局部组合物或化妆品组合物的示例性护肤添加剂包括但不限于：化学或物理防晒剂、自晒黑剂（如二羟基丙酮）、抗痤疮剂（例如间苯二酚、水杨酸、过氧化苯甲酰等）、酶抑制剂、胶原蛋白刺激剂、用于根除老年斑和角化病的药剂、止痛剂、麻醉剂、抗微生物剂（例如抗菌剂、抗酵母剂、抗真菌剂和抗病毒剂）、去头屑剂、抗皮炎剂、止痒剂、止吐剂、抗炎剂、抗过角化剂（antihyperkeratolytic agents）、止汗剂、抗银屑病剂、抗皮脂溢剂、抗组胺剂、皮肤增白剂、去色素沉着剂（depigmentating agents）、皮肤舒缓/愈合剂（例如芦荟提取物、尿囊素等）、皮质类固醇、激素、蛋白质或肽、维生素及其衍生物（例如维生素A、维生素E、维生素B3、维生素B5等）、去角质剂、类视黄醇（例如视黄酸和视黄醇）、金合欢醇、没药醇、植烷三醇、甘油、尿素、胍（例如氨基胍）、克霉唑（clotrimazole）、酮康唑（ketoconazole）、咪康唑（miconozole）、灰黄霉素、羟嗪（hydroxyzine）、苯海拉明（diphenhydramine）、普莫卡因（pramoxine）、利多卡因（lidocaine）、普鲁卡因（procaine）、甲哌卡因（mepivacaine）、莫诺苯宗（monobenzone）、红霉素、四环素、克林霉素（clindamycin）、甲氯环素（meclocyline）、米诺环素（minocycline）、氢醌、萘普生（naproxen）、布洛芬（ibuprofen）、茶碱、色甘酸、沙丁胺醇、外用类固醇（例如氢化可的松、氢化可的松-21-乙酸酯、氢化可的松-17-戊酸酯和氢化可的松-17-丁酸酯）、倍他米松戊酸酯、倍他米松二丙酸酯、过氧化苯甲酰、克罗他米通（crotamiton）、普萘洛尔（propranolol）、普鲁米近（promethazine）及其混合物或衍生物。在本发明的优选但非必需的实施方案中，局部组合物包含一种或多种选自以下的护肤活性物：防晒剂、自晒黑剂、抗老化剂、抗皱剂、抗痤疮剂、抗微生物剂、抗炎剂、皮肤增白剂、蛋白质或肽、维生素及其衍生物、去角质剂、刺激DNA修复的成分、提供免疫保护的成分、刺激细胞更新的成分、刺激皮肤屏障修复的成分、保湿剂、以及它们的混合物。
载体
化妆品可接受的载体还可以含有一种或多种油，其可以是有机硅、有机物或其混合物。如果存在的话，这样的油可以占总组合物的约0.1-99重量％，并且包括挥发性或非挥发性的有机硅，如环聚甲基硅氧烷（cyclomethicone）；甲基聚三甲基硅氧烷（methyltrimethicone）；八甲基三硅氧烷；十甲基四硅氧烷；十二甲基五硅氧烷；聚二甲基硅氧烷；苯基聚三甲基硅氧烷；三甲基甲硅烷氧基苯基聚二甲基硅氧烷；苯基聚二甲基硅氧烷；十六烷基聚二甲基硅氧烷；聚二甲基硅氧烷共聚醇；十六烷基聚二甲基硅氧烷共聚醇；甘油化有机硅，如月桂醇PEG-9聚二甲基甲硅烷氧基乙基聚二甲基硅氧烷（lauryl PEG-9polydimethylsiloxyethyl dimethicone）；或其混合物。合适的酯包括C4-30脂肪酸和C1-C20单醇、二醇或多元醇的单酯、二酯或三酯，例如甘油的脂肪酸酯（例如硬脂酸酯、山嵛酸酯和异硬脂酸酯）或α-羟基酸（如柠檬酸、苹果酸或乳酸）的脂肪酸酯等。合适的烃包括单体或聚合烯烃或α-烯烃，如聚异丁烯、聚癸烯、聚丁烯或其氢化衍生物。
化妆品可接受的载体还可以包含一种或多种湿润剂。如果存在的话，它们可占总组合物的约0.1-20重量％，并且包括C1-4亚烷基二醇，如丁二醇、丙二醇、乙二醇、甘油等。
化妆品可接受的载体还可以含有一种或多种蜡，其优选具有约30-150℃的熔点。如果存在的话，这样的蜡可以占总组合物的约0.1-45重量％，并且包括动物蜡、植物蜡、矿物蜡或硅酮蜡。实例包括烷基聚二甲基硅氧烷、硬脂基聚二甲基硅氧烷、小烛树蜡、聚乙烯、地蜡、蜂蜡等。
化妆品可接受的载体还可以包含一种或多种有机基硅氧烷弹性体，其是乳化或非乳化的。如果存在的话，这样的弹性体可以占总组合物的约0.1-30重量％。合适的弹性体的实例包括聚二甲基硅氧烷/乙烯基聚二甲基硅氧烷交联聚合物；聚二甲基硅氧烷/聚二甲基硅氧烷PEG/PPG 10/15交联聚合物；等。
化妆品可接受的载体还可以包含一种或多种颜料或粉末或其混合物。如果存在的话，这些颜料或粉末的建议范围是总组合物的约0.1-85重量％。这些颜料或粉末的粒度可以为约0.05至200微米，但优选约50至100微米。颜料的实例包括有机颜料，如D&C或FD&C色料或其色淀，包括蓝色、棕色、红色等；或无机氧化铁，如棕色氧化铁、黄色氧化铁、绿色氧化铁、红色氧化铁。合适的粉末包括二氧化钛、尼龙、PMMA、氮化硼、云母等。
化妆品可接受的载体还可以包含一种或多种非离子表面活性剂，特别是如果本发明的局部组合物或化妆品组合物以乳液形式提供的话。如果存在的话，这样的表面活性剂可以占总组合物的约0.1-20重量％。合适的表面活性剂包括乙氧基化脂肪C6-30醇，例如硬脂醇聚氧乙烯醚（steareth）、山嵛醇聚氧乙烯醚（beheneth）、鲸蜡醇聚氧乙烯醚（ceteth），其中各个表面活性剂之后的数字是指可在2至250范围内的重复环氧乙烷基团的数目，例如steareth-2（硬脂醇聚氧乙烯(2)醚）、beheth-30（山嵛醇聚氧乙烯(30)醚）等。
虽然已经在上文中参照具体实施方案、特征和方面描述了本发明，但是将认识到，本发明不会由此受到限制，而是在实用性上扩展到其它修改、变型、应用和实施方案，并且因此所有这些其它的修改、变型、应用和实施方案要被视为在本发明的精神和范围内。
Claims (4)
1.一种形成经涂布颗粒的方法，其包括以下步骤：
a）在第一容器中搅拌一定体积的核颗粒，同时将所述核颗粒加热至约40℃的平均温度；
b）在第二容器中将乙烯基官能的有机硅聚合物、氢化物官能的交联剂和金属催化剂组合以形成预混物；
c）将所述核颗粒与所述预混物组合以形成混合物；
d）将所述混合物加热至约80℃的平均温度，然后使所述混合物冷却至环境温度。
2.根据权利要求1所述的方法，其进一步包括以下步骤：从所述混合物中分离具有小于约45微米的平均粒度的颗粒。
3.根据权利要求1所述的方法，其中所述金属催化剂选自钌、铑、钯、锇、铱和铂、及其配合物和混合物。
4.根据权利要求1所述的方法，其中所述核颗粒包含二氧化钛、氧化锌或其组合。
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| PCT/US2016/037570 WO2017003688A1 (en) | 2015-06-29 | 2016-06-15 | Method for forming particles with cross-linked coatings for cosmetic applications |
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Also Published As
| Publication number | Publication date |
|---|---|
| AU2016285447A1 (en) | 2018-01-25 |
| JP2018519316A (ja) | 2018-07-19 |
| WO2017003688A1 (en) | 2017-01-05 |
| US20160374931A1 (en) | 2016-12-29 |
| EP3313354A1 (en) | 2018-05-02 |
| EP3313354A4 (en) | 2018-12-05 |
| KR20180011362A (ko) | 2018-01-31 |
| CA2990163A1 (en) | 2017-01-05 |
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