CN107802644A - Nasal wash and nasal irrigator - Google Patents
Nasal wash and nasal irrigator Download PDFInfo
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- CN107802644A CN107802644A CN201711217694.4A CN201711217694A CN107802644A CN 107802644 A CN107802644 A CN 107802644A CN 201711217694 A CN201711217694 A CN 201711217694A CN 107802644 A CN107802644 A CN 107802644A
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- nasal wash
- nasal
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- salt
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H35/00—Baths for specific parts of the body
- A61H35/04—Baths for specific parts of the body for the nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0468—Liquids non-physiological
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0618—Nose
Abstract
The invention provides a kind of nasal wash and nasal irrigator.The nasal wash is made up of water soluble chitosan class material, salt and water, and salt is physiology salt or sea salt, and the mass content of the water soluble chitosan class material in nasal wash is 0.2~4%, and the mass content of the salt in nasal wash is 0.85~0.92%.Above-mentioned nasal wash uses main component of the water soluble chitosan class material as nasal wash, and does not add acid or alkaline Auto-regulator, no mucosal irritation, and compliance is good；The discharge isotonic thing of nasal cavity abscess can be effectively rinsed after salt dissolving in nasal wash, coordinate the good filming and moisture retention of water soluble chitosan class material, film being formed in nasal cavity inwall, long-acting moistening effect is provided, mitigate mycteroxerosis, reduce pain degree, accelerate cell migration, mitigate inflammatory reaction.Above-mentioned nasal wash does not introduce other any components or complicated processing technique, greatly reduces production cost.
Description
Technical field
The present invention relates to pharmaceutical technology field, in particular to a kind of nasal wash and nasal irrigator.
Background technology
Nose is the door of human body respiration, undertakes the key physiological functions such as breathing and immune defense.Hereditary variation, environment
Pathogenic factor, removing function or immune defense function exception etc. can trigger various nasal cavity inflammations.Epidemiology survey shows, I
State's rhinitis incidence of disease is up to 37%, and wherein allergic rhinitis is about 11.3%, it has also become influence people's quality of life chronic disease it
One.With environmental pollution, the aggravation of haze and rhythm of life is too fast, psychological pressure aggravates, in recent years nasal cavity, disease of nasal sinus
The incidence of disease steeply rises, and not only has a strong impact on patient health, while bring tremendous economic to bear.Drug therapy is (mainly including nose
Spray glucocorticoid and oral Loratadine), physical treatment (nasal douche) be current clinical primary treatment regimen.Medicine
Respond well to treatment fast, but long-term use can produce drug resistance and can produce organic injury.
Nasal douche is the common method for treating nasal cavity and disease of nasal sinus, because simple to operate and curative effect and tolerance are good
It is good, by the generally accreditation of doctor and patient.Also it is used for the prevention of flu as a kind of novel medicine feeding mode in recent years and controls
Treat.It is generally believed that the mechanism of action of nasal douche mainly includes：1. improving Nasal mucociliary function, strengthen defense function；2. drop
Low schneiderian membrane oedema degree, reduce secretion or ooze out；3. reduce inflammatory factor；4. physical removal acts on, it is dirty that nasal cavity is discharged in time
Dirt recovers normal physiological context.
Commercially available nasal wash is broadly divided into physiological saline, isotonic seawater, drug containing composite buffering liquid and cflush
Liquid etc., first two product are the market mainstreams.Physiological saline or isotonic marine and aquatic product composition are simple, can effectively rinse discharge nasal cavity purulence
It is swollen to wait exudate, but it is bad that rear patient's compliance is used for multiple times without repair to mucous layer, cilium layer etc..Drug containing is compound slow
Fliud flushing be mostly physiological saline or compound buffer solution containing antibiotic, still without repair function and be easily caused bacterial drug resistance increase.
Domestic many main of cflush liquid are combined into clearing heat and detoxicating or heat-clearing and damp-drying drug traditional Chinese medicine ingredients with physiological saline, are formulated
Complexity, cost are high and effect is not notable.For example the nasal wash that Publication No. CN103861000A patent application provides is matched somebody with somebody
Comprising more than 20 kinds of Chinese herbal medicine, through decocting and filtering three times for a long time three times in side, raw material, formula and technique are more complicated, production
Cycle is grown, and is unfavorable for risk management and quality control.Such as Publication No. CN106619969A and CN10514771A patent Shen
It please be to solve schneiderian membrane to repair problem, in being introduced into formula, low-molecular-weight hyaluronic acid, extend the moisture preserving time improvement of mucous membrane
Cell migration, but still be the compound prescription containing traditional Chinese medicine ingredients, composition, complex process and production cycle are grown, and are not easy to produce control
And cost control.
The content of the invention
It is a primary object of the present invention to provide a kind of nasal wash and nasal irrigator, to solve in the prior art
Nasal wash complicated component and the problem of high cost.
To achieve these goals, according to an aspect of the invention, there is provided a kind of nasal wash, nasal wash
It is made up of water soluble chitosan class material, salt and water, salt is physiology salt or sea salt, the water soluble chitosan class in nasal wash
The mass content of material is 0.2~4%, and the mass content of the salt in nasal wash is 0.85~0.92%.
Further, the mass content of the water soluble chitosan class material in above-mentioned nasal wash is 0.5~1.8%.
Further, the mass content of the salt in above-mentioned nasal wash is 0.88~0.90%.
Further, above-mentioned water soluble chitosan class material is water soluble chitosan or water-solubility chitosan derivative.
Further, viscosity A≤30mPa.s of above-mentioned water-solubility chitosan derivative, deacetylation are 75~98%, taken
Dai Du is >=0.8.
Further, 5≤A of viscosity≤25mPa.s of above-mentioned water-solubility chitosan derivative, deacetylation be 80~
95%th, substitution value is≤1.0.
Further, above-mentioned water-solubility chitosan derivative is selected from carboxymethyl chitosan, hydroxypropyl chitosan, ethoxy shell
Glycan, hydroxyl butyl chitosan, chitosan hydrochloride, chitosan quaternary ammonium salt, chitosan lactate, glutamate, shell gather
Any one or more in sugar sulfate.
According to another aspect of the present invention, there is provided a kind of nasal irrigator, including rinse utensil and nasal wash, nose
Chamber flushing liquor is any of the above-described kind of nasal wash.
Further, above-mentioned flusher includes：Bottle, there is accommodating chamber；Flush pipe, be removably disposed on bottle and
Connected with accommodating chamber, nasal wash is arranged in accommodating chamber.
Further, above-mentioned flush pipe is rocker-type flush pipe.
Apply the technical scheme of the present invention, above-mentioned nasal wash is using water soluble chitosan class material as nasal douche
The main component of liquid, and without adding acid or alkaline Auto-regulator, no mucosal irritation, compliance are good；In nasal wash
Salt dissolving after its be functionally equivalent to physiological saline or isotonic seawater, can effectively rinse discharge the isotonic thing of nasal cavity abscess, hydrous water
The good filming and moisture retention of soluble chitosan class material, it can form film in nasal cavity inwall after use and long-acting moisturizing effect is provided
Fruit, mitigate mycteroxerosis, reduce pain degree, be easy to cell migration；Based on the bioactivity of water soluble chitosan class material, it can
Effectively facilitate epithelial cell proliferation and suppress fibroblast proliferation, the speed and quality of cell migration can be accelerated；It is simultaneously water-soluble
Property chitosan also have certain antibacterial and anti-inflammation functions, can be effectively improved environment in nasal cavity, mitigate inflammatory reaction.Above-mentioned nasal wash is not
Other any components or complicated processing technique are introduced, therefore is not likely to produce cross pollution or processing aid residual, pole in production
Reduce production cost greatly, shorten the production cycle, the quality control and risk management being easy in production process.
Embodiment
It should be noted that in the case where not conflicting, the feature in embodiment and embodiment in the application can phase
Mutually combination.The present invention is described in detail below in conjunction with embodiment.
As the application background technology is analyzed, nasal wash complicated component of the prior art, cause its cost compared with
High and complex manufacturing, cycle are longer.In order to solve the above problems, this application provides a kind of nasal wash and nasal cavity to rush
Wash device.
In a kind of typical embodiment of the application, there is provided a kind of nasal wash, the nasal wash is by water-soluble
Property chitosan class material, salt and water composition, salt is physiology salt or sea salt, the water soluble chitosan class material in nasal wash
Mass content is 0.2~4%, and the mass content of the salt in nasal wash is 0.85~0.92%.
Above-mentioned nasal wash uses main component of the water soluble chitosan class material as nasal wash, and does not add
Plus acidic or alkaline Auto-regulator, no mucosal irritation, compliance are good；It is functionally equivalent to after salt dissolving in nasal wash
Physiological saline or isotonic seawater, the discharge isotonic thing of nasal cavity abscess can be effectively rinsed, coordinates the good of water soluble chitosan class material
Film forming and moisture retention, it can form film in nasal cavity inwall after use and long-acting moistening effect is provided, mitigate mycteroxerosis, reduce pain
Pain degree, is easy to cell migration；Based on the bioactivity of water soluble chitosan class material, its can effectively facilitate epithelial cell proliferation and
Suppress fibroblast proliferation, the speed and quality of cell migration can be accelerated；Water soluble chitosan also has certain antibacterial to disappear simultaneously
Inflammation effect, can be effectively improved environment in nasal cavity, mitigate inflammatory reaction.Above-mentioned nasal wash does not introduce other any components or complexity
Processing technology, therefore cross pollution or processing aid residual are not likely to produce in production, greatly reduce production cost, shorten
Production cycle, the quality control and risk management being easy in production process.
In order to further play the cell migration performance of water soluble chitosan class material and antibacterial and anti-inflammation functions, preferably on
State the mass content of the water soluble chitosan class material in nasal wash for 0.5~1.8%, more preferably 0.8~
1.2%.
Due to containing water soluble chitosan class material in above-mentioned nasal wash, it can play good reparation to mucous membrane
Effect, therefore the salt content in nasal wash can be adjusted in concentration of customary physiological salt solution or isotonic saline solution or so,
The flushing action for not influenceing nasal wash also will not be because of the excessive damage caused to nasal cavity of concentration, certainly, on balancing
State flushing action and reduce damage to schneiderian membrane, the mass content of the salt in preferably above-mentioned nasal wash for 0.88~
0.90%.
Water soluble chitosan class material for the application can be water soluble chitosan or water-solubility chitosan derivative.
Wherein the performance of water soluble chitosan is relatively stable, water-solubility chitosan derivative according to its different performance of substituent slightly not
Together, but the effect of the cell migration performance of water soluble chitosan, bioactivity and anti-inflammation can be kept.
The physical parameter of water-solubility chitosan derivative it is different may its function can difference, in order to ensure using above-mentioned
The water-solubility chitosan derivative of content can realize more preferably effect, and preferably above-mentioned water-solubility chitosan derivative glues
Spend A≤30mPa.s, deacetylation is 75~98%, substitution value is >=0.8.By controlling the viscous of water-solubility chitosan derivative
Degree A≤30mPa.s, deacetylation are 75~98%, make its dissolubility in water more preferable, are disperseed evenly, and then its effect
More fully play；By controlling the substitution value of water-solubility chitosan derivative, more sufficient performance of keeping humidity is made it have, because
This is more beneficial for reducing pain degree.5≤A of viscosity≤25mPa.s of further preferred above-mentioned water soluble chitosan class material, de- second
Acyl degree is 80~95%, substitution value is≤1.0.
Water-solubility chitosan derivative for the application is from the prior art in conventional water-solubility chitosan derivative
Selected, preferably above-mentioned water-solubility chitosan derivative is selected from carboxymethyl chitosan, hydroxypropyl chitosan, ethoxy shell and gathered
Sugar, hydroxyl butyl chitosan, chitosan hydrochloride, chitosan quaternary ammonium salt, chitosan lactate, glutamate, chitosan
Any one or more in sulfuric ester.The biological safety of above-mentioned each water-solubility chitosan derivative is more stable.
In another typical embodiment of the application, there is provided a kind of nasal irrigator, including rinse utensil and nose
Chamber flushing liquor, the nasal wash are any of the above-described kind of nasal wash.
The nasal wash of the application uses main component of the water soluble chitosan class material as nasal wash, and does not have
There is addition acid or alkaline Auto-regulator, no mucosal irritation, compliance are good；Salt dissolving late-acting in nasal wash etc.
Physiological saline or isotonic seawater are same as, the discharge isotonic thing of nasal cavity abscess can be effectively rinsed, coordinate water soluble chitosan class material
Good filming and moisture retention, it can form film in nasal cavity inwall after use and long-acting moistening effect is provided, mitigate mycteroxerosis, drop
Low pain degree, is easy to cell migration；Based on the bioactivity of water soluble chitosan class material, it can effectively facilitate epithelial cell increasing
Grow and suppress fibroblast proliferation, the speed and quality of cell migration can be accelerated；Water soluble chitosan also has certain anti-simultaneously
Bacterium antiinflammation, environment in nasal cavity can be effectively improved, mitigate inflammatory reaction.Above-mentioned nasal wash do not introduce other any components or
Complicated processing technique, therefore cross pollution or processing aid residual are not likely to produce in production, greatly reduce production cost, contracting
Short production cycle, the quality control and risk management being easy in production process.And above-mentioned nasal wash is due to water-soluble good
It is good, therefore can adapt to the various nasal irrigators in current conventional structure.
For the ease of depositing and using, preferably above-mentioned flusher includes bottle and flush pipe, and bottle has accommodating chamber；Rinse
Pipe is removably disposed on bottle and connected with accommodating chamber, and nasal wash is arranged in accommodating chamber.It is further preferably above-mentioned
Flush pipe is rocker-type flush pipe.
Below with reference to embodiment and comparative example, the beneficial effect of the application is further illustrated.
Water soluble chitosan class material is purchased from that Zhejiang Austria is emerging, Dezhou Hai Lian, Wei Fanghai used by following examples
Source company.
Embodiment 1
Nasal wash is made up of water soluble chitosan, physiology salt and water, the water soluble chitosan in nasal wash
Mass content is 1%, and the mass content of the physiology salt in nasal wash is 0.9%, and the viscosity of water soluble chitosan is
20mPa.s, deacetylation 85%.
Embodiment 2
Nasal wash is made up of carboxymethyl chitosan, physiology salt and water, the carboxymethyl chitosan in nasal wash
Mass content is 1%, and the mass content of the physiology salt in nasal wash is 0.9%, and the viscosity of carboxymethyl chitosan is
20mPa.s, deacetylation 85%, substitution value 0.8.
Embodiment 3
Nasal wash is made up of carboxymethyl chitosan, physiology salt and water, the carboxymethyl chitosan in nasal wash
Mass content is 1%, and the mass content of the physiology salt in nasal wash is 0.9%, and the viscosity of carboxymethyl chitosan is
30mPa.s, deacetylation 75%, substitution value 1.0.
Embodiment 4
Nasal wash is made up of carboxymethyl chitosan, physiology salt and water, the carboxymethyl chitosan in nasal wash
Mass content is 1%, and the mass content of the physiology salt in nasal wash is 0.9%, and the viscosity of carboxymethyl chitosan is
5mPa.s, deacetylation 98%, substitution value 0.9.
Embodiment 5
Nasal wash is made up of carboxymethyl chitosan, physiology salt and water, the carboxymethyl chitosan in nasal wash
Mass content is 1%, and the mass content of the physiology salt in nasal wash is 0.9%, and the viscosity of carboxymethyl chitosan is
25mPa.s, deacetylation 80%, substitution value 0.9.
Embodiment 6
Nasal wash is made up of carboxymethyl chitosan, physiology salt and water, the chitosan hydrochloride in nasal wash
Mass content is 1%, and the mass content of the physiology salt in nasal wash is 0.9%, and the viscosity of chitosan hydrochloride is
20mPa.s, deacetylation 85%, substitution value 0.8.
Embodiment 7
Nasal wash is made up of carboxymethyl chitosan, physiology salt and water, the chitosan hydrochloride in nasal wash
Mass content is 1%, and the mass content of the physiology salt in nasal wash is 0.9%, and the viscosity of chitosan hydrochloride is
35mPa.s, deacetylation 70%, substitution value 0.8.
Embodiment 8
Nasal wash is made up of carboxymethyl chitosan, physiology salt and water, the glutamate in nasal wash
Mass content be 1%, the mass content of the physiology salt in nasal wash is 0.9%, and the viscosity of glutamate is
20mPa.s, deacetylation 85%, substitution value 0.8.
Embodiment 9
Nasal wash is made up of carboxymethyl chitosan, physiology salt and water, the sulfated chitosan in nasal wash
Mass content is 1%, and the mass content of the physiology salt in nasal wash is 0.9%, and the viscosity of sulfated chitosan is
20mPa.s, deacetylation 85%, substitution value 0.8.
Embodiment 10
Nasal wash is made up of carboxymethyl chitosan, physiology salt and water, the hydroxypropyl chitosan in nasal wash
Mass content is 1%, and the mass content of the physiology salt in nasal wash is 0.9%, and the viscosity of hydroxypropyl chitosan is
20mPa.s, deacetylation 85%, substitution value 0.8.
Embodiment 11
Nasal wash is made up of carboxymethyl chitosan, physiology salt and water, the carboxymethyl chitosan in nasal wash
Mass content is 0.2%, and the mass content of the physiology salt in nasal wash is 0.90%, and the viscosity of carboxymethyl chitosan is
20mPa.s, deacetylation 85%, substitution value 0.8.
Embodiment 12
Nasal wash is made up of carboxymethyl chitosan, physiology salt and water, the carboxymethyl chitosan in nasal wash
Mass content is 4%, and the mass content of the physiology salt in nasal wash is 0.90%, and the viscosity of carboxymethyl chitosan is
20mPa.s, deacetylation 85%, substitution value 0.8.
Embodiment 13
Nasal wash is made up of carboxymethyl chitosan, physiology salt and water, the carboxymethyl chitosan in nasal wash
Mass content is 0.5%, and the mass content of the physiology salt in nasal wash is 0.90%, and the viscosity of carboxymethyl chitosan is
20mPa.s, deacetylation 85%, substitution value 0.8.
Embodiment 14
Nasal wash is made up of carboxymethyl chitosan, physiology salt and water, the carboxymethyl chitosan in nasal wash
Mass content is 1.8%, and the mass content of the physiology salt in nasal wash is 0.90%, and the viscosity of carboxymethyl chitosan is
20mPa.s, deacetylation 85%, substitution value 0.8.
Embodiment 15
Nasal wash is made up of carboxymethyl chitosan, physiology salt and water, the carboxymethyl chitosan in nasal wash
Mass content is 1%, and the mass content of the physiology salt in nasal wash is 0.85%, and the viscosity of carboxymethyl chitosan is
20mPa.s, deacetylation 85%, substitution value 0.8.
Embodiment 16
Nasal wash is made up of carboxymethyl chitosan, physiology salt and water, the carboxymethyl chitosan in nasal wash
Mass content is 1%, and the mass content of the physiology salt in nasal wash is 0.88%, and the viscosity of carboxymethyl chitosan is
20mPa.s, deacetylation 85%, substitution value 0.8.
Embodiment 17
Nasal wash is made up of carboxymethyl chitosan, physiology salt and water, the carboxymethyl chitosan in nasal wash
Mass content is 1%, and the mass content of the physiology salt in nasal wash is 0.92%, and the viscosity of carboxymethyl chitosan is
20mPa.s, deacetylation 85%, substitution value 0.8.
Embodiment 18
Nasal wash is made up of carboxymethyl chitosan, sea salt and water, the matter of the carboxymethyl chitosan in nasal wash
It is 1% to measure content, and the mass content of the sea salt in nasal wash is 0.9%, the viscosity of carboxymethyl chitosan is 20mPa.s,
Deacetylation is 85%, substitution value 0.8.
Comparative example 1
Nasal wash is made up of sea salt and water, and the mass content of the sea salt in nasal wash is 0.9%.
Comparative example 2
Nasal wash is made up of carboxymethyl chitosan and water, the mass content of the carboxymethyl chitosan in nasal wash
For 3%, the viscosity of carboxymethyl chitosan is 20mPa.s, deacetylation 85%, substitution value 0.8.
Comparative example 3
Nasal wash is made up of carboxymethyl chitosan, physiology salt and water, the carboxymethyl chitosan in nasal wash
Mass content is 0.1%, and the mass content of the physiology salt in nasal wash is 0.9%, and the viscosity of carboxymethyl chitosan is
20mPa.s, deacetylation 85%, substitution value 0.8.
Comparative example 4
Nasal wash is made up of carboxymethyl chitosan, physiology salt and water, the carboxymethyl chitosan in nasal wash
Mass content is 5%, and the mass content of the physiology salt in nasal wash is 0.9%, and the viscosity of carboxymethyl chitosan is
20mPa.s, deacetylation 85%, substitution value 0.8.
Comparative example 5
Nasal wash is made up of carboxymethyl chitosan, physiology salt and water, the carboxymethyl chitosan in nasal wash
Mass content is 1%, and the mass content of the physiology salt in nasal wash is 1.0%, and the viscosity of carboxymethyl chitosan is
20mPa.s, deacetylation 85%, substitution value 0.8.
Comparative example 6
Nasal wash is made up of carboxymethyl chitosan, physiology salt, xylose alcohol and water, the carboxymethyl shell in nasal wash
The mass content of glycan is 1%, and the mass content of the xylitol in nasal wash is 10%, the physiology salt in nasal wash
Mass content be 0.9%, the viscosity of carboxymethyl chitosan is 20mPa.s, deacetylation 85%, substitution value 0.8.
Comparative example 7
Nasal wash is made up of carboxymethyl chitosan, physiology salt, xylitol, sodium carbonate and water, in nasal wash
The mass content of carboxymethyl chitosan is 1%, and the mass content of the xylitol in nasal wash is 10%, in nasal wash
The mass content of sodium carbonate be 3%, the mass content of the physiology salt in nasal wash is 0.9%, carboxymethyl chitosan
Viscosity is 20mPa.s, deacetylation 85%, substitution value 0.8.
The nasal wash of the various embodiments described above and comparative example is placed in the spray bottle of nasal irrigator, exhorts patients with rhinitis
Each spray sooner or later once, respectively counts the using effect of 100 patients daily, and record is as follows.
Table 1-1
Table 1-2
Table 1-3
Table 1-4
Table 1-5
Note：1 to 3 day symptom has clear improvement to be notable；4 to 10 days symptoms have clear improvement to be general；Disease after 11 days
Shape is just improved as poorly efficient.
It can be seen that the application's according to the contrast of the data in above-mentioned each table, especially embodiment and comparative example 1 and 2
Effect is obviously improved after adding salt and water soluble chitosan simultaneously in nasal wash；And according to embodiment and comparative example 6 and 7
Contrast is as can be seen that further addition xylitol and sodium carbonate can not further function as obvious improvement in nasal wash
Effect, illustrates that the nasal douche formula of liquid of the application is simply efficient.
As can be seen from the above description, the above embodiments of the present invention realize following technique effect：
Above-mentioned nasal wash uses main component of the water soluble chitosan class material as nasal wash, and does not add
Plus acidic or alkaline Auto-regulator, no mucosal irritation, compliance are good；It is functionally equivalent to after salt dissolving in nasal wash
Physiological saline or isotonic seawater, the discharge isotonic thing of nasal cavity abscess can be effectively rinsed, coordinates the good of water soluble chitosan class material
Film forming and moisture retention, it can form film in nasal cavity inwall after use and long-acting moistening effect is provided, mitigate mycteroxerosis, reduce pain
Pain degree, is easy to cell migration；Based on the bioactivity of water soluble chitosan class material, its can effectively facilitate epithelial cell proliferation and
Suppress fibroblast proliferation, the speed and quality of cell migration can be accelerated；Water soluble chitosan also has certain antibacterial to disappear simultaneously
Inflammation effect, can be effectively improved environment in nasal cavity, mitigate inflammatory reaction.Above-mentioned nasal wash does not introduce other any components or complexity
Processing technology, therefore cross pollution or processing aid residual are not likely to produce in production, greatly reduce production cost, shorten
Production cycle, the quality control and risk management being easy in production process.
The preferred embodiments of the present invention are the foregoing is only, are not intended to limit the invention, for the skill of this area
For art personnel, the present invention can have various modifications and variations.Within the spirit and principles of the invention, that is made any repaiies
Change, equivalent substitution, improvement etc., should be included in the scope of the protection.
Claims (10)
1. a kind of nasal wash, it is characterised in that the nasal wash is by water soluble chitosan class material, salt and water group
It is physiology salt or sea salt into, the salt, the mass content of the water soluble chitosan class material in the nasal wash is
0.2~4%, the mass content of the salt in the nasal wash is 0.85~0.92%.
2. nasal wash according to claim 1, it is characterised in that the water soluble shells in the nasal wash
The mass content of poly- glucide is 0.5~1.8%.
3. nasal wash according to claim 1, it is characterised in that the quality of the salt in the nasal wash
Content is 0.88~0.90%.
4. nasal wash according to claim 1, it is characterised in that the water soluble chitosan class material is water solubility
Chitosan or water-solubility chitosan derivative.
5. nasal wash according to claim 4, it is characterised in that the viscosity A of the water-solubility chitosan derivative
≤ 30mPa.s, deacetylation are 75~98%, substitution value is >=0.8.
6. nasal wash according to claim 4, it is characterised in that the viscosity 5 of the water-solubility chitosan derivative
≤ A≤25mPa.s, deacetylation are 80~95%, substitution value is≤1.0.
7. nasal wash according to claim 4, it is characterised in that the water-solubility chitosan derivative is selected from carboxylic first
Base enclosure glycan, hydroxypropyl chitosan, hydroxyethyl chitosan, hydroxyl butyl chitosan, chitosan hydrochloride, chitosan quaternary ammonium salt, shell
Any one or more in glycan lactate, glutamate, sulfated chitosan.
8. a kind of nasal irrigator, including rinse utensil and nasal wash, it is characterised in that the nasal wash is right
It is required that the nasal wash any one of 1 to 7.
9. nasal irrigator according to claim 8, it is characterised in that the flusher includes：
Bottle, there is accommodating chamber；
Flush pipe, it is removably disposed on the bottle and is connected with the accommodating chamber, the nasal wash is arranged on institute
State in accommodating chamber.
10. nasal irrigator according to claim 9, it is characterised in that the flush pipe is rocker-type flush pipe.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711217694.4A CN107802644A (en) | 2017-11-28 | 2017-11-28 | Nasal wash and nasal irrigator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711217694.4A CN107802644A (en) | 2017-11-28 | 2017-11-28 | Nasal wash and nasal irrigator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107802644A true CN107802644A (en) | 2018-03-16 |
Family
ID=61590233
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| CN201711217694.4A Pending CN107802644A (en) | 2017-11-28 | 2017-11-28 | Nasal wash and nasal irrigator |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108721610A (en) * | 2018-06-25 | 2018-11-02 | 济南瑞丰生物工程有限公司 | A kind of nasal cavity wetting agent of chitosan-containing and preparation method thereof |
| CN109394678A (en) * | 2018-10-15 | 2019-03-01 | 安徽徽科生物工程技术有限公司 | Tissue irrigating solutions and its application in the medical field |
| CN111544389A (en) * | 2019-02-11 | 2020-08-18 | 宁波绿康康复科技有限公司 | Physiological saline nasal cavity nursing spray liquid |
| CN111714448A (en) * | 2020-07-06 | 2020-09-29 | 上海诺斯清生物科技有限公司 | Preparation method of nasal cavity care solution and application of nasal cavity care solution to nasal cavity care sprayer |
| CN112472669A (en) * | 2020-12-18 | 2021-03-12 | 曲阜师范大学 | Nasal spray based on red pepper extract and heparin for preventing influenza and preparation method thereof |
| CN114748245A (en) * | 2022-03-25 | 2022-07-15 | 威海世纪博康海藻有限公司 | Cotton swab and application thereof |
| CN115590878A (en) * | 2022-10-14 | 2023-01-13 | 云飞生物药业（吉林）有限公司（Cn） | Hypertonic seawater nasal spray |
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| CN201684153U (en) * | 2010-05-16 | 2010-12-29 | 段晓光 | Manual nasal cavity flushing device |
| CN105326786A (en) * | 2015-11-09 | 2016-02-17 | 合肥九研医药科技开发有限公司 | Nasal irrigant composition and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN201684153U (en) * | 2010-05-16 | 2010-12-29 | 段晓光 | Manual nasal cavity flushing device |
| CN105326786A (en) * | 2015-11-09 | 2016-02-17 | 合肥九研医药科技开发有限公司 | Nasal irrigant composition and preparation method thereof |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108721610A (en) * | 2018-06-25 | 2018-11-02 | 济南瑞丰生物工程有限公司 | A kind of nasal cavity wetting agent of chitosan-containing and preparation method thereof |
| CN109394678A (en) * | 2018-10-15 | 2019-03-01 | 安徽徽科生物工程技术有限公司 | Tissue irrigating solutions and its application in the medical field |
| CN111544389A (en) * | 2019-02-11 | 2020-08-18 | 宁波绿康康复科技有限公司 | Physiological saline nasal cavity nursing spray liquid |
| CN111714448A (en) * | 2020-07-06 | 2020-09-29 | 上海诺斯清生物科技有限公司 | Preparation method of nasal cavity care solution and application of nasal cavity care solution to nasal cavity care sprayer |
| CN112472669A (en) * | 2020-12-18 | 2021-03-12 | 曲阜师范大学 | Nasal spray based on red pepper extract and heparin for preventing influenza and preparation method thereof |
| CN114748245A (en) * | 2022-03-25 | 2022-07-15 | 威海世纪博康海藻有限公司 | Cotton swab and application thereof |
| CN115590878A (en) * | 2022-10-14 | 2023-01-13 | 云飞生物药业（吉林）有限公司（Cn） | Hypertonic seawater nasal spray |
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