CN115590878A - Hypertonic seawater nasal spray - Google Patents
Hypertonic seawater nasal spray Download PDFInfo
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- CN115590878A CN115590878A CN202211260789.5A CN202211260789A CN115590878A CN 115590878 A CN115590878 A CN 115590878A CN 202211260789 A CN202211260789 A CN 202211260789A CN 115590878 A CN115590878 A CN 115590878A
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- canning
- nasal
- seawater
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- sea salt
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Abstract
The invention provides a hypertonic seawater nasal spray which comprises sea salt and high-purity water, wherein the content of the sea salt is 0.8-10.0g/L; the preparation process of the hypertonic seawater nasal cavity spray comprises the following steps: step 1: weighing: weighing sea salt and high-purity water according to a proportion; step 2: preparation: putting the raw materials into a liquid preparation tank for preparation; and step 3: canning: canning the prepared solution obtained in the step (2), and putting the solution into a plastic bottle in the canning process, and canning by using a canning machine; and 4, step 4: packaging: a capping machine is used for capping the plastic bottles in the step 3, and a labeling machine is used for labeling the packaged plastic bottles; and 5: and (6) warehousing of finished products. The invention can transfer intracellular fluid to extracellular fluid by osmotic pressure principle, thereby eliminating nasal mucosa edema caused by various reasons, improving nasal cavity ventilation and further achieving the effect of reducing congestion.
Description
Technical Field
The invention relates to the field of nasal cavity cleaning, in particular to a hypertonic seawater nasal cavity spray.
Background
The hypertonic and alkaline effects can change the rheological properties of mucus blanket liquid, reduce mucus viscosity, and increase intracellular calcium ion release, thereby accelerating Mao Baidong frequency and improving ciliary function.
The hypertonic action can destroy cell biomembranes and remove bacteria, and in addition, the alkaline characteristic also enables the activity of the nasal mucus lysozyme to be in a higher level, thereby playing the roles of antibiosis and antiphlogosis.
The seawater is rich in various minerals and microelements beneficial to human body, and has effects of enhancing antibacterial, antiinflammatory, inducing epithelial cell proliferation, and promoting wound healing.
The nasal cavity is the initial part of the respiratory passage and is also our olfactory organ. It belongs to a highly differentiated organ which is sensitive to chemical stimulation and has important functions of receiving external chemical information, identifying the environment and identifying enemies and my friends. However, such important organs are sore and full of pores, and the scars are tired, and allergic rhinitis and acute and chronic rhinitis are the main manifestations; allergic rhinitis has become a global health problem today, and can lead to many illnesses and loss of labor. It is undeniable that various nasal problems not only disturb normal work, study and social contact of patients, but also seriously affect physical and mental health of the patients. At present, no method exists for radical treatment, and the traditional cleaning mode is inconvenient, so that a hypertonic seawater nasal spray is needed, which can effectively help to relieve allergic rhinitis symptoms, relieve uncomfortable symptoms such as nasal dryness, nasal obstruction, nasal itching, nasal discharge and the like, can also be used for daily sanitary care of nasal cavity, and helps patients to clean the nasal cavity easily, conveniently and effectively.
Disclosure of Invention
The invention aims to solve the problem that the existing nasal cavity spray is inconvenient to use, and provides a hypertonic seawater nasal cavity spray which can effectively help to relieve allergic rhinitis symptoms, relieve uncomfortable symptoms such as nasal dryness, nasal obstruction, nasal itching, rhinorrhea and the like, can also be used for daily sanitary care of nasal cavities, and helps patients to clean the nasal cavities easily, conveniently and effectively.
The technical scheme provided by the invention is as follows:
a hypertonic seawater nasal spray comprises sea salt, humectant, glycerol, lecithin and high-purity water, wherein the sea salt content is 0.8-10.0g/L, the glycerol content is 5g/L, the lecithin content is 0.3g/L, the humectant content is 0.8g/L, the components also comprise water-soluble chitosan, and the water-soluble chitosan content is 0.2g/L.
Preferably, the humectant is one or more of trehalose, guava gum and propylene glycol.
The preparation method of the hypertonic seawater nasal cavity spray comprises the following steps:
step 1: weighing: weighing the substances according to the proportion;
step 2: preparation: putting the raw materials into a liquid preparation tank for preparation; specifically, the method comprises the following operations
1) Taking sea salt, adding the sea salt into purified water in a corresponding proportion, uniformly stirring by using a liquid preparation tank, adding active carbon, and heating to boil to obtain seawater;
2) Firstly, carrying out coarse filtration on the obtained seawater by using a microfiltration membrane with the aperture of 0.45 mu m, then carrying out secondary filtration by using a microfiltration membrane with the aperture of 0.22 mu m, and cooling to room temperature to obtain filtered seawater;
3) Mixing lecithin and glycerol, and stirring the obtained mixture at the rotating speed of 300-500r/min for 30-60min to obtain a mixture of lecithin and glycerol;
4) Adding humectant into the filtered seawater, stirring at a rotation speed of 200-300r/min for 1-2 hr, standing for 2-4 hr, and filtering to obtain moisturizing solution;
5) Adding the mixture of lecithin and glycerol into the moisturizing liquid, homogenizing under 30-50MPa for 3-6min, performing ultrasonic treatment at 100-200W for 5-10min, adding essence, stirring at 200-400r/min for 30-50min, and filtering;
and step 3: canning: canning the prepared solution obtained in the step 2, and putting the solution into a plastic bottle in the canning process, and canning by using a canning machine;
and 4, step 4: packaging: a capping machine is used for capping the plastic bottles in the step 3, and a labeling machine is used for labeling the packaged plastic bottles;
and 5: and (6) warehousing the finished product.
The invention has the advantages that
The main component of the hypertonic seawater nasal spray provided by the invention is hypertonic seawater, and the hypertonic seawater nasal spray can transfer intracellular fluid to extracellular fluid through an osmotic pressure principle, so that nasal mucosa edema caused by various reasons is eliminated, nasal ventilation is improved, and the decongestion effect is achieved. The nasal cavity cleaner is used for cleaning the nasal cavity of patients with nasal cavity diseases such as acute and chronic rhinitis, allergic rhinitis, nasal polyp, nasosinusitis and the like, is also used for cleaning the nasal cavity after rhinitis operation, relieves uncomfortable symptoms such as nasal dryness, nasal obstruction, nasal itching, rhinorrhea and the like, and can also be used for daily sanitary nursing of the nasal cavity.
Detailed Description
The present invention is described in further detail below to enable those skilled in the art to practice the invention with reference to the description.
The nasal cavity cleaner is used for cleaning nasal cavities of patients with nasal cavity diseases such as acute and chronic rhinitis, allergic rhinitis, nasal polyp, nasosinusitis and the like, is also used for cleaning the nasal cavities after rhinitis operations, relieves uncomfortable symptoms such as nasal dryness, nasal obstruction, nasal itching, rhinorrhea and the like, can also be used for daily sanitary nursing of the nasal cavities, can transfer intracellular liquid to extracellular liquid through the osmotic pressure principle, eliminates nasal mucosa edema caused by various reasons, improves the nasal cavity ventilation, and achieves the effect of reducing congestion.
The invention provides a hypertonic seawater nasal spray which comprises sea salt, a humectant, glycerol, lecithin and high-purity water, wherein the sea salt content is 0.8-10.0g/L, the glycerol content is 5g/L, the lecithin content is 0.3g/L, the humectant content is 0.8g/L, the components also comprise water-soluble chitosan, and the water-soluble chitosan content is 0.2g/L.
Preferably, the humectant is one or more of trehalose, guava gum and propylene glycol.
The humectant has the functions of adsorbing water molecules, and has the advantages of super-strong moisture retention, refreshing, excellent moisture retention safety and moisture retention protection on nasal cavity epidermis.
The water-soluble chitosan is prepared by carboxylating and modifying chitosan, is easy to dissolve in water and has stable property.
The preparation method of the hypertonic seawater nasal cavity spray comprises the following steps:
step 1: weighing: weighing the substances according to the proportion;
step 2: preparation: putting the raw materials into a liquid preparation tank for preparation; specifically, the method comprises the following operations
1) Taking sea salt, adding the sea salt into purified water in a corresponding proportion, uniformly stirring by using a liquid preparation tank, adding active carbon, and heating to boil to obtain seawater;
2) Firstly, carrying out coarse filtration on the obtained seawater by using a microfiltration membrane with the aperture of 0.45 mu m, then carrying out secondary filtration by using a microfiltration membrane with the aperture of 0.22 mu m, and cooling to room temperature to obtain filtered seawater;
3) Mixing lecithin and glycerol, and stirring the obtained mixture at the rotating speed of 300-500r/min for 30-60min to obtain a mixture of lecithin and glycerol;
4) Adding humectant into the filtered seawater, stirring at a rotation speed of 200-300r/min for 1-2 hr, standing for 2-4 hr, and filtering to obtain moisturizing solution;
5) Adding the mixture of lecithin and glycerol into the moisturizing liquid, homogenizing under 30-50MPa for 3-6min, performing ultrasonic treatment at 100-200W for 5-10min, adding essence, stirring at 200-400r/min for 30-50min, and filtering;
and step 3: canning: canning the prepared solution obtained in the step 2, and putting the solution into a plastic bottle in the canning process, and canning by using a canning machine;
and 4, step 4: packaging: using a capping machine to cap the plastic bottles in the step 3, and using a labeling machine to label the packaged plastic bottles;
and 5: and (6) warehousing the finished product.
The preparation process is simple, so that the product of the invention has good effect, and can sterilize the nasal cavity and provide high moisture retention
The packaged product of the invention should be stored in a well ventilated room with air relative humidity not greater than 80% and no corrosive substances.
And (3) packaging and transporting:
the hypertonic seawater nasal spray is used for preventing direct sunlight, rain and snow immersion and heavy extrusion in the transportation process.
The application range of the invention is as follows:
(1) The nasal cavity cleaner is used for cleaning the nasal cavity of patients with nasal cavity diseases such as acute and chronic rhinitis, allergic rhinitis, nasal polyp, nasosinusitis and the like, is also used for cleaning the nasal cavity after rhinitis operation, relieves uncomfortable symptoms such as nasal dryness, nasal obstruction, nasal itching, rhinorrhea and the like, and can also be used for daily sanitary care of the nasal cavity.
(2) Intended use
The nasal cavity of a patient with nasal cavity diseases is cleaned and the daily sanitary nursing of the nasal cavity is carried out.
The invention is suitable for people:
for the users with the diseases, the hypertonic seawater nasal cavity sprayer is used in the nasal cavity and is not used in the sterile environment; before using the product, the product application instruction should be read and then used.
The high-permeability seawater nasal spray provided by the invention has the main component of high-permeability seawater, and transfers the intracellular fluid of the nasal mucosa to the outside of the cells by utilizing the osmotic dehydration principle to eliminate the edema of the nasal mucosa. The nasal cavity cleaner is used for cleaning the nasal cavity of patients with nasal cavity diseases such as acute and chronic rhinitis, allergic rhinitis, nasal polyp, nasosinusitis and the like, is also used for cleaning the nasal cavity after rhinitis operation, relieves uncomfortable symptoms such as nasal dryness, nasal obstruction, nasal itching, rhinorrhea and the like, and can also be used for daily sanitary nursing of the nasal cavity.
While embodiments of the invention have been disclosed above, it is not intended to be limited to the uses set forth in the specification and examples. It can be applied to all kinds of fields suitable for the present invention. Additional modifications will readily occur to those skilled in the art. The invention is therefore not to be limited to the specific details described herein, without departing from the general concept as defined by the appended claims and their equivalents.
Claims (3)
1. The hypertonic seawater nasal spray is characterized by comprising 0.8-10.0g/L of sea salt, 5g/L of glycerin, 0.3g/L of lecithin and 0.8g/L of humectant, and further comprising water-soluble chitosan with the content of 0.2g/L.
2. The nasal rinse of claim 1 wherein the humectant is one or more of trehalose, guava and propylene glycol.
3. The hypertonic seawater nasal spray of any one of claims 1-2, wherein the preparation method of the hypertonic seawater nasal spray comprises:
step 1: weighing: weighing the substances according to the proportion;
step 2: preparation: putting the raw materials into a liquid preparation tank for preparation; specifically, the method comprises the following operations
1) Taking sea salt, adding the sea salt into purified water in a corresponding proportion, uniformly stirring by using a liquid preparation tank, adding active carbon, and heating to boil to obtain seawater;
2) Firstly, carrying out coarse filtration on the obtained seawater by using a microfiltration membrane with the aperture of 0.45 mu m, then carrying out secondary filtration by using a microfiltration membrane with the aperture of 0.22 mu m, and cooling to room temperature to obtain filtered seawater;
3) Mixing lecithin and glycerol, and stirring the obtained mixture at the rotating speed of 300-500r/min for 30-60min to obtain a mixture of lecithin and glycerol;
4) Adding humectant into the filtered seawater, stirring at a rotation speed of 200-300r/min for 1-2 hr, standing for 2-4 hr, and filtering to obtain humectant solution;
5) Adding the mixture of lecithin and glycerol into the moisturizing liquid, homogenizing under 30-50MPa for 3-6min, performing ultrasonic treatment at 100-200W for 5-10min, adding essence, stirring at 200-400r/min for 30-50min, and filtering;
and 3, step 3: canning: canning the prepared solution obtained in the step 2, and putting the solution into a plastic bottle in the canning process, and canning by using a canning machine;
and 4, step 4: packaging: using a capping machine to cap the plastic bottles in the step 3, and using a labeling machine to label the packaged plastic bottles;
and 5: and (6) warehousing the finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211260789.5A CN115590878A (en) | 2022-10-14 | 2022-10-14 | Hypertonic seawater nasal spray |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211260789.5A CN115590878A (en) | 2022-10-14 | 2022-10-14 | Hypertonic seawater nasal spray |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115590878A true CN115590878A (en) | 2023-01-13 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211260789.5A Pending CN115590878A (en) | 2022-10-14 | 2022-10-14 | Hypertonic seawater nasal spray |
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| Country | Link |
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| CN (1) | CN115590878A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107802644A (en) * | 2017-11-28 | 2018-03-16 | 安徽徽科生物工程技术有限公司 | Nasal wash and nasal irrigator |
| CN113662962A (en) * | 2021-08-12 | 2021-11-19 | 广州零界医药有限公司 | Hypertonic seawater nasal sprayer |
| CN113694024A (en) * | 2021-08-05 | 2021-11-26 | 广州零界医药有限公司 | Physiological seawater nasal cavity sprayer |
-
2022
- 2022-10-14 CN CN202211260789.5A patent/CN115590878A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107802644A (en) * | 2017-11-28 | 2018-03-16 | 安徽徽科生物工程技术有限公司 | Nasal wash and nasal irrigator |
| CN113694024A (en) * | 2021-08-05 | 2021-11-26 | 广州零界医药有限公司 | Physiological seawater nasal cavity sprayer |
| CN113662962A (en) * | 2021-08-12 | 2021-11-19 | 广州零界医药有限公司 | Hypertonic seawater nasal sprayer |
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