CN101332279B - Traditional Chinese medicine preparation for treating nasal sinusitis, rhinopolypus and nasopharyngitis - Google Patents

Abstract

The invention discloses a Chinese herbal preparation for treating nasosinusitis, rhinopolypus and nasopharyngitis. The Chinese herbal preparation consists of 17 Chinese herbs including Siberian cocklebur fruit, biond magnolia flower, small centipeda herb, szechwan lovage rhizome, heartleaf houttuynia herb, gypsum, milkvetch root, ahurian angelica root, platycodon root, field mint, calamus, luffa rattan carbon, pariphyllin, yellow croaker ear-stone, common burreed tuber, zedoray rhizome and radix glycyrrhizae, etc. Aiming at the cause and the pathogenesis of nasosinusitis, rhinopolypus and nasopharyngitis, the Chinese herbal preparation treats according to different symptoms and achieves good efficacy. The total effective rate is 96.1%, and the cure rate is 72.5%. The Chinese herbal preparation uses the materials exactly with reasonable compatibility and good efficacy. The problem that nasosinusitis, rhinopolypus and nasopharyngitis are difficult to cure is solved.

Description

The Chinese medicine preparation of treatment sinusitis, nasal polyp and nasopharyngitis

Technical field

The present invention relates to a kind of Chinese medicine preparation for the treatment of sinusitis, nasal polyp and nasopharyngitis.

Background technology

Sinusitis, nasal polyp and nasopharyngitis all are common chronic refractory diseases.The traditional Chinese medical science is thought: the generation of sinusitis is normal relevant with the diseases caused by exogenous pathogenic factor seasonal pathogen, its wind, cold, wet, all evil lungs of violating of heat, delay and do not go, nose loses that a surname is smooth, breath is come in and gone out and is obstructed and falls ill, or, lifting dereliction of duty strong, turbid damp because of the improper diet and overtiredness impairment of the spleen, deficiency-weakness of spleen-QI, fortune mistake be stranded spleen and evil poison stay for a long time do not remove, stop up resistance nose key arteries and veins arm, QI-blood circulation is not freely fallen ill.Modern medicine is thought: the generation of sinusitis is mainly infected by anaerobic bacillus(cillus anaerobicus) (70～80%) and antibacterial (20%), form myxedema, plumpness, polypoid change, cause hole mouth nasal meatus complex to block, secular bacteriotoxin, enzyme and Dou Kou block that partial pressure of carbon dioxide raises to the hole, partial pressure of oxygen descends and causes ciliary movement to descend, and nasal mucosa local mucous membrane function of immune system descends and falls ill.Nasopharyngitis is due to nasal cavity, nasal sinuses, bottleneck throat infect, generally also to be caused by flu.Nasal polyp is the long-term inflammation because of nasal cavity, nasal sinuses mucosa, causes inflammatory to change and the edema sample vegetation of formation.Therefore, three's pathogenesis has points of resemblance.In prior art, the traditional Chinese medical science often with Flos Magnoliae Fructus Xanthii powder treatment rhinitis and sinusitis, obtains the curative effect of generally acknowledging in the boundary.But because sinusitis, nasal polyp and nasopharyngitis are pertinacious diseases, traditional Flos Magnoliae Fructus Xanthii powder is difficult to reach the degree of healing, particularly nasal polyp, and the difficulty of healing is bigger, therefore, on traditional prescription basis, also treats in further exploration.

Summary of the invention

The Chinese medicine that the purpose of this invention is to provide a kind of treatment sinusitis, nasal polyp and nasopharyngitis of better efficacy makes its instant effect, cure rate height, and relapse rate is low.

Chinese medicine of the present invention is made by following raw materials by weight proportions:

Fructus Xanthii 60～100 gram Flos Magnoliaes 90～120 gram Herba Centipedae 150～200 grams

Rhizoma Chuanxiong 60～100 gram Herba Houttuyniae 300～360 gram Gypsum Fibrosum 200～280 grams

The Radix Astragali 180～240 gram Radixs Angelicae Dahuricae 60～100 gram Radix Platycodoniss 60～100 grams

Thin He 60～100 gram Rhizoma Acori Gramineis 60～100 gram Ramulus Luffae charcoals 100～150 grams

Rhizoma Paridis 60～100 gram Asteriscus Pseudosciaenaes 60～100 gram rhizoma sparganic 60～100 grams

Rhizoma Curcumae 60～100 gram Radix Glycyrrhizaes 60～100 grams.

The present invention is being principal agent by Fructus Xanthii, Flos Magnoliae, Herba Centipedae, the Radix Angelicae Dahuricae, thin He, they have the effect of " expelling wind and cold, clearing the nasal passage, dehumidifying detumescence, dissipating blood stasis evacuation of pus, refresh oneself, throat ", simultaneously, modern pharmacological research shows: Fructus Xanthii, Flos Magnoliae decoct have antibiotic, bacteriostasis to staphylococcus aureus, anthrax bacillus, pneumobacillus etc.; The Herba Centipedae hot water extract has anti-allergic effects, and the effect of certain mutation and inhibition tumor growth is arranged; That Radix Angelicae Dahuricae decoct has is analgesic, analgesia and antiinflammatory action, and escherichia coli, bacterium sonnei and shigella flexneri, Bacillus proteus, Bacillus typhi etc. are had inhibitory action; Menthol has good inhibition effect to various bacteria, virus, fungus in the Herba Menthae, and antiinflammatory action is arranged, and therefore, the assembly of above-mentioned principal agent can be antibiotic, antiinflammatory, antiviral and antiallergic, and they play main therapeutical effect to the inflammation of nasal cavity and nasopharynx part.On the basis of principal agent, the present invention is equipped with Herba Houttuyniae, Gypsum Fibrosum, Radix Platycodonis, Rhizoma Paridis and strengthens antibiotic, the antiinflammatory of principal agent, antivirus action; Be equipped with Rhizoma Chuanxiong, rhizoma sparganic, Rhizoma Curcumae, Ramulus Luffae charcoal and carry out movable blood soft hard, cooling blood for hemostasis, improve the blood vessel microcirculation, cooperate principal agent to eliminate concha nasalis swelling and change nasal polyp; Be equipped with Asteriscus Pseudosciaenae and strengthen principal agent cold expelling, sensible effect, remove tears simultaneously, change polyp, be equipped with Rhizoma Acori Graminei have one's ideas straightened out refreshment, removing dampness to restore normal function of the stomach, improve memory, be equipped with Radix Astragali benefiting QI for strengthening the superficies, enhancing human body immunity power, be equipped with the Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription at last.

This Chinese medicine preparation is through inventor's clinical practice for many years, and from treating chronic sinusitis, nasal polyp patient totally 1265 examples between 1993～1996 olympiads altogether, its treatment situation and therapeutic outcome are summarized as follows:

One, clinical data

Treat 1265 examples altogether in the period of 1993～1,996 four, wherein male 572 examples, women 693 examples, at 8～74 years old age, the course of disease did not wait in 1～36 year, and all the patient all has nasal obstruction watery nasal discharge history, the dense tears of the 347 example yellow thickness of stream comprise resorption pus tears, and 996 examples are nasal obstruction obviously, 724 examples have headache, and painful area is at most with the forehead, is followed successively by temples, top and occipitalia, 186 examples have hyposmia or disappearance, 42 examples are with polyp, bilateral polyp 17 examples, all among the patients 60～80% with pharyngitis.

Two, diagnosis and efficacy assessment standard

1, diagnostic criteria

The standard of working out with reference to Society of Ophthalmology of China and Chinese hals,Nasen und Ohrenheilkunde magazine editorial board and hals,Nasen und Ohrenheilkunde diagnostics, and according to clinical symptoms performance is suitably revised and is replenished.The one, observe subjective symptom, as vexed the expanding of typical clinical symptom nasal obstruction, pus tears, headache of sinusitis, olfactory sensation descends, and medical history is no less than 10 months; The 2nd, objective determination middle nasal meatus, olfactory cleft or nasal cavity have purulent secretion; The 3rd, nasal sinuses X film making, CT examination shows the plump or sieve hole of hole mouth nasal meatus complex hypertrophy, sphenoid sinus inflammation or hydrops.Meet abovely at least two, promptly can be diagnosed as sinusitis.

2, criterion of therapeutical effect

The recovery from illness standard: subjective symptom and objective determination recover normal, nasal sinuses X film making, and it is normal that CT recovers substantially; The produce effects standard: subjective symptom and objective determination recover normal, and nasal sinuses X film making and CT do not recover normal: the improvement standard: subjective symptom and objective determination partly recover normally, and nasal sinuses X film making and CT examination do not recover normal; Invalid standard: subjective symptom and objective determination do not change.

Three, Therapeutic Method

This Chinese medicine preparation is made capsule, and every contains medicated powder 1 gram, and 3 times on the one, once oral 3, oral 6 of serious symptom (year of a specified duration and nasal polyp) person, seven days one courses of treatment.3 courses of treatment of sinusitis patient wherein; 3～5 courses of treatment of nasal polyp patient; 1～3 course of treatment of nasopharyngitis; Treat check in back a year, judge its curative effect.

Four, therapeutic outcome

Total treatment number	The recovery from illness number	The produce effects number	Good revolution	Invalid number
					1265 examples	917 examples	228 examples	72 examples	48 examples

Cure rate	Obvious effective rate	Improvement rate	Inefficiency	Total effective rate
					72.5％	18％	5.6％	3.9％	96.1％

Check after 1 year has only 38 example recurrences, and relapse rate is 3%, and nasal polyp is 14 examples in this 38 example, accounts for 36.8% of relapse rate.

This Chinese medicine preparation is at the cause of disease and the pathogenesis of sinusitis, nasal polyp and nasopharyngitis, and determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs has obtained above-mentioned good curative effect, and this mainly has benefited from the definite and rational compatibility of medication, has broken the difficulty that sinusitis, nasal polyp and nasopharyngitis are difficult to cure.

The specific embodiment

1, the weight proportion of crude drug of the present invention is as follows:

Fructus Xanthii 60～100 gram Flos Magnoliaes 90～120 gram Herba Centipedae 150～200 grams

Rhizoma Chuanxiong 60～100 gram Herba Houttuyniae 300～360 gram Gypsum Fibrosum 200～280 grams

The Radix Astragali 180～240 gram Radixs Angelicae Dahuricae 60～100 gram Radix Platycodoniss 60～100 grams

Thin He 60～100 gram Rhizoma Acori Gramineis 60～100 gram Ramulus Luffae charcoals 100～150 grams

Rhizoma Paridis 60～100 gram Asteriscus Pseudosciaenaes 60～100 gram rhizoma sparganic 60～100 grams

Rhizoma Curcumae 60～100 gram Radix Glycyrrhizaes 60～100 grams.

2, preparation method

Take by weighing Fructus Xanthii according to quantity, sand is processed remove impurity, and parching to brown is ground into fine powder.

Take by weighing Flos Magnoliae according to quantity, roguing, incision is dried, and is ground into fine powder.

Take by weighing Herba Centipedae according to quantity, the removal of impurity, well sifted dries, and is ground into fine powder.

Take by weighing Radix Glycyrrhizae, Rhizoma Chuanxiong, Herba Houttuyniae, the Radix Astragali, the Radix Angelicae Dahuricae, Radix Platycodonis, Herba Menthae, Rhizoma Acori Graminei, Rhizoma Paridis according to quantity, well sifted, decontamination dry, are ground into fine powder respectively.

Take by weighing Ramulus Luffae according to quantity: decontamination, chopping, roasting charcoal, pulverization.

Take by weighing rhizoma sparganic, Rhizoma Curcumae according to quantity, use soaking in rice vinegar 24 hours, airing, pulverization.

Claim Gypsum Fibrosum, Asteriscus Pseudosciaenae according to quantity, put into drying machine with above-mentioned medicated powder and remove moisture, use disinfection by ultraviolet light then,, or make powder packets with the doses of 3 grams with the dose of 1 gram or encapsulated or make tablet.

Claims (1)

1. Chinese medicine preparation for the treatment of sinusitis, nasal polyp and nasopharyngitis is characterized in that it is made by following materials of weight proportions medicine:

Fructus Xanthii 60～100 gram Flos Magnoliaes 90～120 gram Herba Centipedae 150～200 grams

Rhizoma Chuanxiong 60～100 gram Herba Houttuyniae 300～360 gram Gypsum Fibrosum 200～280 grams

The Radix Astragali 180～240 gram Radixs Angelicae Dahuricae 60～100 gram Radix Platycodoniss 60～100 grams

Thin He 60～100 gram Rhizoma Acori Gramineis 60～100 gram Ramulus Luffae charcoals 100～150 grams

Rhizoma Paridis 60～100 gram Asteriscus Pseudosciaenaes 60～100 gram rhizoma sparganic 60～100 grams

Rhizoma Curcumae 60～100 gram Radix Glycyrrhizaes 60～100 grams.