CN104984251A - Application of pharmaceutical composition in arthritis treatment - Google Patents
Application of pharmaceutical composition in arthritis treatment Download PDFInfo
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- CN104984251A CN104984251A CN201510432542.0A CN201510432542A CN104984251A CN 104984251 A CN104984251 A CN 104984251A CN 201510432542 A CN201510432542 A CN 201510432542A CN 104984251 A CN104984251 A CN 104984251A
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Abstract
The invention discloses an application of a pharmaceutical composition in the arthritis treatment. The pharmaceutical composition is composed of the following components by weight: 60 to 100 grams of cicada slough, 90 to 120 grams of magnolia flower, 150 to 200 grams of centipeda minima, 60 to 100 grams of ligusticum wallichii, 300 to 360 grams of cordate houttuynia, 200 to 280 grams of gypsum, 180 to 240 grams of radix astragali, 60 to 100 grams of dahurian angelica root, 60 to 100 grams of balloonflower root, 60 to 100 grams of mint, 60 to 100 grams of calamus, 100 to 150 grams of towel gourd stem charcoal, 60 to 100 grams of manyleaf paris rhizome, 60 to 100 grams of fish otolith, 60 to 100 grams of rhizoma sparganii, 60 to 100 grams of curcuma rhizome, and 60 to 100 grams of licorice. The pharmaceutical composition can treat arthritis effectively, and has the advantages of good curative effect, no side or toxic effect, and user-friendliness. The clinical cure rate is 30%, and the total effective rate is 95%.
Description
Technical field
The present invention relates to the field of Chinese medicines, the specifically application of a kind of pharmaceutical composition in treatment of arthritis.
Background technology
Arthritis is the general name of osteoarthritis of cervical spine, proliferative cervical spondylosis, cervical syndrome, Cervical disc extrusion, is a kind of illness changing into basis with degeneration pathology.Strain for a long time mainly due to cervical vertebra, hyperosteogeny, or prolapse of intervertebral disc, ligament thicken, and cause cervical vertebra spinal cord, nerve root or vertebral artery pressurized, occur a series of handicapped clinical syndrome.Show as intervertebral disc degradation itself and insecondary a series of pathological change thereof, as vertebra joint unstability, loosen; Nucleus pulposus or deviate from; Bony spur is formed; The spinal canal stenosis etc. of ligament plumpness and secondary, stimulates or has oppressed the tissues such as the nerve root of vicinity, spinal cord, vertebral artery and cervical region sympathetic nerve, cause series of symptoms and sign.
But current medicine is for various reasons, can only alleviate and palliate the agonizing sufferings, can not from solving sufferer at all, therefore, the development of new drug is imperative.
After prescription of the present invention is open as the medicine for the treatment of sinusitis, nasal polyp and nasopharyngitis in the application of CN200810150340.7, we find that in a large amount of clinical practice the party is except curing mainly function, also there is the good efficacy for the treatment of of arthritis, not only onset is rapid, curative effect lasting, and untoward reaction is few.
Summary of the invention
The object of the present invention is to provide the therapeutic use that a kind of pharmaceutical composition is new, be specifically related to a kind of curative effect high, without the application of pharmaceutical composition in treatment of arthritis of toxicity, to solve the problem proposed in above-mentioned background technology.
For achieving the above object, the invention provides following technical scheme:
The application of pharmaceutical composition in treatment of arthritis, is made up of the crude drug of following weight proportion: Periostracum Cicadae 60 ~ 100 grams, Flos Magnoliae 90 ~ 120 grams, Herba Centipedae 150 ~ 200 grams, Rhizoma Chuanxiong 60 ~ 100 grams, Herba Houttuyniae 300 ~ 360 grams, 200 ~ 280 grams, Gypsum Fibrosum, the Radix Astragali 180 ~ 240 grams, the Radix Angelicae Dahuricae 60 ~ 100 grams, Radix Platycodonis 60 ~ 100 grams, thin He 60 ~ 100 grams, Rhizoma Acori Graminei 60 ~ 100 grams, Ramulus Luffae charcoal 100 ~ 150 grams, Rhizoma Paridis 60 ~ 100 grams, Asteriscus Pseudosciaenae 60 ~ 100 grams, Rhizoma Sparganii 60 ~ 100 grams, Rhizoma Curcumae 60 ~ 100 grams, 60 ~ 100 grams, Radix Glycyrrhizae.
The mechanism of action of each crude drug in the present invention: Periostracum Cicadae, Flos Magnoliae decoct have antibacterial, bacteriostasis to staphylococcus aureus, anthrax bacillus, pneumobacillus etc.Herba Centipedae hot water extract has anti-allergic effects, and has the effect of certain mutation and Tumor suppression growth.Radix Angelicae Dahuricae decoct have antipyretic, analgesia and antiinflammatory action, have inhibitory action to escherichia coli, bacterium sonnei and shigella flexneri, Bacillus proteus, Bacillus typhi etc.In Herba Menthae, menthol has good inhibitory action to various bacteria, virus, fungus, and has antiinflammatory action.
Rhizoma Chuanxiong activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Herba Houttuyniae acrid in the mouth, cold, return lung meridian.Heat-clearing and toxic substances removing, detumescence can treat skin ulcer, promoting urination to remove dampness, clearing away heat to cure dysentery, invigorating the stomach and promoting digestion, with the lung abscess controlling excess-heat, pyretic toxicity, damp, disease heat are trouble, sore swollen toxin,
hemorrhoidhave blood in stool, retention of heat in the spleen and stomach etc.Modern pharmacology experiment shows, this product has the effect such as antibacterial, antiviral, raising immunity of organisms, diuresis.
Gypsum Fibrosum life with having clearing away heat-fire, effect that relieving restlessness is quenched the thirst; Forge with having expelling pus and promoting granulation, removing dampness, effect of hemostasis.Be usually used in fever caused by exogenous pathogenic factors, high hot excessive thirst, dyspnea and cough due to lung-heat, the high Sheng of stomach-fire, headache, toothache.
The Radix Astragali have enhancing human body immunity function,
protect the liver,
diuresis, defying age, anti-stress,
blood pressure loweringantibacterial action more widely.But table excess pathogen is contained, retention of dampness due to stagnation of QI, and food stagnation is stagnated,
carbunclefrom the beginning of or the excess syndrome such as pyretic toxicity Shang Sheng after bursting, and
hyperactivity of YANG due to deficiency of YINperson, must prohibit clothes.
Radix Platycodonis lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.
Rhizoma Acori Graminei have have one's ideas straightened out, eliminate the phlegm, effect of loose wind, epidemic disease of can dispelling Fructus Alpiniae Oxyphyllae, building body.The successive dynasties classic of TCM is all using the medicine of Rhizoma Acori Graminei rhizome as Fructus Alpiniae Oxyphyllae the chest stuffiness relieving, hearing-improing and eyesight improving, damp eliminating removing toxic substances.
Ramulus Luffae charcoal relaxing muscles and tendons to promote blood circulation; Relieving cough and resolving phlegm; Removing toxic substances parasite killing.Main soreness of waist and knee joint;
numb limbs and tense tendons; Menoxenia;
cough with copious phlegm; Nasopharynx;
gingival atrophy;
to shed baby teeth tooth.
Rhizoma Paridis heat-clearing and toxic substances removing, antiasthmatic-antitussive, relieve dizziness, high fever, infantile convulsions, epilepsy, etc. arresting convulsion, detumescence hemostasis.Cure mainly: carbuncle, furuncle, scrofula, sore throat, chronic tracheitis, infantile convulsion is twitched, snake bite and insect sting, women's irregular menstruation, traumatic injury.
Asteriscus Pseudosciaenae fossil, treating stranguria, antiinflammatory.Control
stranguria caused by urinary stone,
dysuria,
otitis media,
rhinitis,
sinusitis with purulent discharge.
The circulation of qi promoting of Rhizoma Sparganii removing blood stasis, removing food stagnancy pain relieving.
Rhizoma Curcumae: rhizome claims "
rhizoma Curcumae", hyoscine, cure mainly "
coagulation of QI-blood,
trusted subordinate's distending pain,
lump in the abdomen, gather,
dyspepsiado not disappear, women
blood stasisamenorrhea,
traumatic injuryhave a pain." tuber claims " green filament Radix Curcumae ", has circulation of qi promoting
resolving depression, removing blood stasis with potent drugs, the function of pain relieving.
Radix Glycyrrhizae is used for
insufficiency of heart-QI, severe palpitation, irregularly intermittent and regularly intermittent pulse and deficiency of spleen-QI and stomach-QI, fatigue and weakness etc.,
carbunclethe anxious pain of skin infection, laryngopharynx swelling and pain, asthma and cough, stomachache, stomachache and gastrocnemius contraction etc.Radix Glycyrrhizae has the effect of similar adrenocortical hormone sample.Inhibitory action is had to the gastroxia that histamine causes; And have antiacid and alleviate the effect of gastrointestinal smooth muscle spasm.Licoflavone, Radix Glycyrrhizae extractum and enoxolone all have obvious antitussive effect; Phlegm-dispelling functions is also more remarkable.Radix Glycyrrhizae also has antiinflammatory, anti-allergic effects, can protect throat and the tunica mucosa tracheae of inflammation.Radix Glycyrrhizae extractum and glycyrrhizic acid have the Detoxication of similar glucuronic acid to some poisonous substance.
Compared with prior art, the invention has the beneficial effects as follows:
The present invention is the active drug for the treatment of of arthritis, and curative effect is high, without toxicity, easy to use, clinical cure rate is 30%, and total effective rate is 95%.For arthritic provides good treatment condition.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1
In the embodiment of the present invention, the application of pharmaceutical composition in treatment of arthritis, is made up of following bulk drugs: Periostracum Cicadae 60 grams, Flos Magnoliae 90 grams, Herba Centipedae 150 grams, Rhizoma Chuanxiong 60 grams, Herba Houttuyniae 300 grams, 200 grams, Gypsum Fibrosum, the Radix Astragali 180 grams, the Radix Angelicae Dahuricae 60 grams, Radix Platycodonis 60 grams, thin He 60 grams, Rhizoma Acori Graminei 60 grams, Ramulus Luffae charcoal 100 grams, Rhizoma Paridis 60 grams, Asteriscus Pseudosciaenae 60 grams, Rhizoma Sparganii 60 grams, Rhizoma Curcumae 60 grams, 60 grams, Radix Glycyrrhizae.
Embodiment 2
In the embodiment of the present invention, the application of pharmaceutical composition in treatment of arthritis, is made up of the crude drug of following weight proportion: Periostracum Cicadae 100 grams, Flos Magnoliae 120 grams, Herba Centipedae 200 grams, Rhizoma Chuanxiong 100 grams, Herba Houttuyniae 360 grams, 280 grams, Gypsum Fibrosum, the Radix Astragali 240 grams, the Radix Angelicae Dahuricae 100 grams, Radix Platycodonis 100 grams, thin He 100 grams, Rhizoma Acori Graminei 100 grams, Ramulus Luffae charcoal 150 grams, Rhizoma Paridis 100 grams, Asteriscus Pseudosciaenae 100 grams, Rhizoma Sparganii 100 grams, Rhizoma Curcumae 100 grams, 100 grams, Radix Glycyrrhizae.
Embodiment 3
In the embodiment of the present invention, the application of pharmaceutical composition in treatment of arthritis, is made up of the crude drug of following weight proportion: Periostracum Cicadae 80 grams, Flos Magnoliae 105 grams, Herba Centipedae 175 grams, Rhizoma Chuanxiong 80 grams, Herba Houttuyniae 330 grams, 240 grams, Gypsum Fibrosum, the Radix Astragali 210 grams, the Radix Angelicae Dahuricae 80 grams, Radix Platycodonis 80 grams, thin He 80 grams, Rhizoma Acori Graminei 80 grams, Ramulus Luffae charcoal 125 grams, Rhizoma Paridis 80 grams, Asteriscus Pseudosciaenae 80 grams, Rhizoma Sparganii 80 grams, Rhizoma Curcumae 80 grams, 80 grams, Radix Glycyrrhizae.
Preparation method: take Periostracum Cicadae according to quantity, sand processs remove impurity, parching to brown, is ground into fine powder.Take Flos Magnoliae according to quantity, roguing, incision is dried, and is ground into fine powder.Take Herba Centipedae according to quantity, the removal of impurity, well sifted dries, and is ground into fine powder.Take Radix Glycyrrhizae, Rhizoma Chuanxiong, Herba Houttuyniae, the Radix Astragali, the Radix Angelicae Dahuricae, Radix Platycodonis, Herba Menthae, Rhizoma Acori Graminei, Rhizoma Paridis according to quantity, well sifted, decontamination, dry, be ground into fine powder respectively.Take Ramulus Luffae according to quantity: decontamination, chopping, roasting charcoal, pulverization.Take Rhizoma Sparganii, Rhizoma Curcumae according to quantity, with soaking in rice vinegar 24 hours, airing, pulverization.Claim Gypsum Fibrosum, Asteriscus Pseudosciaenae according to quantity, put into drying machine except moisture with above-mentioned medicated powder, then use disinfection by ultraviolet light, with the dose of 1 gram or encapsulated or make tablet, or make powder packets with the dose of 3 grams.
Embodiment 4
Therapeutic effect:
One, the standard of case is selected
Be applicable to various arthritis, it is unfavorable that clinical manifestation is dizziness, tinnitus, heaviness of the head as being covered, nausea and vomiting, uncomfortable in chest, neck is changed one's position, and the vertical pain of companion's shoulder arm numbness waits disease.Therefore, all have above symptom, all as the standard selecting case.
Two, diagnostic criteria
Arthritic cardinal symptom is dizzy, headache, numb limbs and tense tendons, limbs paralysis numbness, belong to Chinese medicine arthromyodynia, flaccidity, headache, the category such as dizzy.Its pathogenic factor, studies carefully its source, has direct feeling exopathogen, retention of blood stasis; Also have stagnation of liver-QI depressed, fire-transformation impairment of YIN, or insufficiency of the spleen expectorant is raw, retardance meridians, or many strains, cause deficiency of kidney-essence, deficiency of marrow-reservoir.In Different types of etiopathogenises, especially in dizziness, occupy critical role with expectorant, the stasis of blood.
It is unfavorable that in diagnosis, common manifestation is dizziness, tinnitus, heaviness of the head as being covered, nausea and vomiting, uncomfortable in chest, neck is changed one's position, and the vertical pain of companion's shoulder arm numbness waits disease.Tongue is dark red, thick and greasy fur, stringy and rolling pulse.All have above-mentioned feature and symptom all can be diagnosed as arthritis.
Three, therapeutic scheme
3 times on the one, each 3g, warm water delivery service.Within 30 days, be a course for the treatment of, 2 courses for the treatment of add up curative effect.
Four, efficacy assessment standard
1, clinical cure: pain, numbness, the symptom such as dizzy, somatic feature score reduce >=95%, x-ray display is normal.
2, effective: pain, numbness, the symptom such as dizzy, somatic feature score reduce >=70%, <95%, x-ray display is clearly better.
3, effective: pain, numbness, symptom, the somatic feature score such as dizzy reduce >=30%, <70%, and x-ray shows improvement.
4, invalid: pain, numbness, the symptom such as dizzy, somatic feature score reduce <30%, x-ray display is without changing.
Five, statistical disposition
In 100 routine patients, male 55 people, female 45 people.The course of disease is the shortest is 1 month, and the longest is 4 years 06 months, and average course of disease is 1 year 08 months.Wherein neck type 33 example, accounts for 33%; Spondylotic radiculopathy 28 example, accounts for 28%; Vertebral artery type 10 example, accounts for 10%; Myeloid form 4 example, accounts for 4%; Sympathetic type 2 example, accounts for 2%; Mixed type 23 example, accounts for 23%.Clinical cure 30 example, accounts for 30%; Effective 45 examples, account for 45%; Take a turn for the better 20 examples, accounts for 20%; Invalid 5 examples, account for 5%.Total effective rate is 95%.
Above patient treatment, in medication, is showed no toxicity, shows that this medicine is the medicine for the treatment of various effective and safe.
Shown by above-mentioned, the present invention is the active drug for the treatment of of arthritis, and curative effect is high, without toxicity, easy to use, have actual clinical meaning, for arthritic provides good treatment condition.
Typical example:
1, Feng, man, 53 years old, patient suffered from arthritis for many years, drug administration is treated, and has no any improvement after taking a period of time, and after using 1 course for the treatment of of the present invention, symptom is clearly better, after taking 2 courses for the treatment of of the present invention, transference cure, physical recovery is normal, follows up a case by regular visits to without recurrence after 1 year.
2, all certain, man, 58 years old, patient suffers from arthritis more than 2 years, remove too much family hospital admission, took multiple Drug therapy, have no any improvement, after taking 1 course for the treatment of of the present invention, above-mentioned symptom is obviously alleviated, after continuing to use 2 courses for the treatment of of the present invention, former transference cure completely without, physical recovery is normal, follows up a case by regular visits to without recurrence after half a year.
3, Wu, female, 51 years old, patient's shoulder, upper arm pain, increased the weight of when cough, sneeze.Remove hospital admission, be diagnosed as arthritis, all have no improvement with crossing a lot of Drug therapy, after taking 1 course for the treatment of of the present invention, above-mentioned symptom is clearly better, and after continuing to use 2 courses for the treatment of of water preparation of the present invention, above-mentioned symptom disappears, and follows up a case by regular visits to without recurrence after 1 year
4. king so-and-so, female 38 years old, diagnosis: arthritis.Oral medicine, remission on the same day, movable voluntarily, oral drugs one week, clinical cure.
To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and when not deviating from spirit of the present invention or basic feature, the present invention can be realized in other specific forms.Therefore, no matter from which point, all should embodiment be regarded as exemplary, and be nonrestrictive, scope of the present invention is limited by claims instead of above-mentioned explanation, and all changes be therefore intended in the implication of the equivalency by dropping on claim and scope are included in the present invention.
In addition, be to be understood that, although this description is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should by description integrally, and the technical scheme in each embodiment also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.
Claims (1)
1. the application of pharmaceutical composition in treatment of arthritis, it is characterized in that, be made up of the crude drug of following weight proportion: Periostracum Cicadae 60 ~ 100 grams, Flos Magnoliae 90 ~ 120 grams, Herba Centipedae 150 ~ 200 grams, Rhizoma Chuanxiong 60 ~ 100 grams, Herba Houttuyniae 300 ~ 360 grams, 200 ~ 280 grams, Gypsum Fibrosum, the Radix Astragali 180 ~ 240 grams, the Radix Angelicae Dahuricae 60 ~ 100 grams, Radix Platycodonis 60 ~ 100 grams, thin He 60 ~ 100 grams, Rhizoma Acori Graminei 60 ~ 100 grams, Ramulus Luffae charcoal 100 ~ 150 grams, Rhizoma Paridis 60 ~ 100 grams, Asteriscus Pseudosciaenae 60 ~ 100 grams, Rhizoma Sparganii 60 ~ 100 grams, Rhizoma Curcumae 60 ~ 100 grams, 60 ~ 100 grams, Radix Glycyrrhizae.
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| CN201510432542.0A CN104984251A (en) | 2015-07-22 | 2015-07-22 | Application of pharmaceutical composition in arthritis treatment |
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| CN201510432542.0A CN104984251A (en) | 2015-07-22 | 2015-07-22 | Application of pharmaceutical composition in arthritis treatment |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101332279A (en) * | 2008-07-15 | 2008-12-31 | 何社明 | Traditional Chinese medicine preparation for treating nasal sinusitis, rhinopolypus and nasopharyngitis |
| CN104306591A (en) * | 2014-09-28 | 2015-01-28 | 苏州市天灵中药饮片有限公司 | Traditional Chinese medicine preparation for treating cervical spondylosis and preparation method of traditional Chinese medicine preparation |
| CN104491734A (en) * | 2014-12-30 | 2015-04-08 | 郑州中医骨伤病医院 | Yuyuanzhima pill traditional Chinese medicine for treating cervical spondylosis |
-
2015
- 2015-07-22 CN CN201510432542.0A patent/CN104984251A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101332279A (en) * | 2008-07-15 | 2008-12-31 | 何社明 | Traditional Chinese medicine preparation for treating nasal sinusitis, rhinopolypus and nasopharyngitis |
| CN104306591A (en) * | 2014-09-28 | 2015-01-28 | 苏州市天灵中药饮片有限公司 | Traditional Chinese medicine preparation for treating cervical spondylosis and preparation method of traditional Chinese medicine preparation |
| CN104491734A (en) * | 2014-12-30 | 2015-04-08 | 郑州中医骨伤病医院 | Yuyuanzhima pill traditional Chinese medicine for treating cervical spondylosis |
Non-Patent Citations (1)
| Title |
|---|
| 王子华等: "杨豪教授治疗类风湿关节炎临床经验", 《吉林中医药》 * |
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