CN107771183A - 抗‑人‑her3抗体及其用途 - Google Patents

抗‑人‑her3抗体及其用途 Download PDF

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Publication number
CN107771183A
CN107771183A CN201680035940.1A CN201680035940A CN107771183A CN 107771183 A CN107771183 A CN 107771183A CN 201680035940 A CN201680035940 A CN 201680035940A CN 107771183 A CN107771183 A CN 107771183A
Authority
CN
China
Prior art keywords
antibody
cancer
seq
her3
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680035940.1A
Other languages
English (en)
Chinese (zh)
Inventor
T·查尔德
O·迪布勒伊
A·佩勒格林
C·拉鲍雷
J-F·普罗斯特
J-M·巴雷
S·德戈夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Medical And Health Research Institute
Gama Mar Buss Pharmaceutical Co
Universite de Montpellier
Institut Regional du Cancer de Montpellier
Original Assignee
National Medical And Health Research Institute
Gama Mar Buss Pharmaceutical Co
Universite de Montpellier
Institut Regional du Cancer de Montpellier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Medical And Health Research Institute, Gama Mar Buss Pharmaceutical Co, Universite de Montpellier, Institut Regional du Cancer de Montpellier filed Critical National Medical And Health Research Institute
Publication of CN107771183A publication Critical patent/CN107771183A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CN201680035940.1A 2015-05-06 2016-05-02 抗‑人‑her3抗体及其用途 Pending CN107771183A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15305695.7 2015-05-06
EP15305695.7A EP3091033A1 (en) 2015-05-06 2015-05-06 Anti-human-her3 antibodies and uses thereof
PCT/EP2016/059739 WO2016177664A1 (en) 2015-05-06 2016-05-02 Anti-human-her3 antibodies and uses thereof

Publications (1)

Publication Number Publication Date
CN107771183A true CN107771183A (zh) 2018-03-06

Family

ID=53059029

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680035940.1A Pending CN107771183A (zh) 2015-05-06 2016-05-02 抗‑人‑her3抗体及其用途

Country Status (12)

Country Link
US (1) US11001634B2 (https=)
EP (2) EP3091033A1 (https=)
JP (1) JP6987742B2 (https=)
CN (1) CN107771183A (https=)
BR (1) BR112017023874A2 (https=)
CA (1) CA2985143C (https=)
ES (1) ES2905531T3 (https=)
PL (1) PL3292154T3 (https=)
PT (1) PT3292154T (https=)
RS (1) RS62912B1 (https=)
RU (1) RU2017138468A (https=)
WO (1) WO2016177664A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110724194A (zh) * 2018-07-17 2020-01-24 上海生物制品研究所有限责任公司 抗her3人源化单克隆抗体及其制剂
WO2024077775A1 (zh) * 2022-10-13 2024-04-18 深圳市百士通科技开发有限公司 一种多功能重组抗体及其制备方法和应用

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EP3448987A4 (en) 2016-04-29 2020-05-27 Voyager Therapeutics, Inc. COMPOSITIONS FOR TREATING A DISEASE
EP3448874A4 (en) 2016-04-29 2020-04-22 Voyager Therapeutics, Inc. COMPOSITIONS FOR TREATING A DISEASE
CA3112043A1 (en) 2018-09-10 2020-03-19 Mirati Therapeutics, Inc. Combination therapies
GB201913079D0 (en) * 2019-09-11 2019-10-23 Hummingbird Bioscience Holdings Pte Ltd Treatment and prevention of cancer using her3 antigen-binding molecules
CN113135995B (zh) * 2020-01-17 2022-08-12 上海生物制品研究所有限责任公司 抗her3单克隆抗体及其应用
EP4257153B1 (en) * 2020-12-04 2025-11-12 Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. Antibody-drug conjugate, and intermediate thereof, preparation method therefor, and application thereof
AU2022293634A1 (en) * 2021-06-15 2024-01-18 Beijing Sinotau Bio-Pharmaceuticals Technology Co., Ltd. Anti-her3 antibody, antibody drug conjugate containing the same, and use thereof
MX2024009174A (es) * 2022-01-25 2024-08-09 Medilink Therapeutics Suzhou Co Ltd Anticuerpo contra her3, conjugado y uso del mismo.
CN116444672B (zh) * 2023-06-13 2023-11-03 上海偌妥生物科技有限公司 人表皮生长因子3的抗体、其制备方法及其应用
WO2025248097A2 (en) * 2024-05-31 2025-12-04 Gamamabs Pharma Humanized anti-human her3 antibodies and uses thereof

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WO2012017058A1 (en) * 2010-08-04 2012-02-09 Glycotope Gmbh Improved recombinant human follicle-stimulating hormone
WO2012036094A1 (ja) * 2010-09-17 2012-03-22 独立行政法人産業技術総合研究所 肺癌鑑別マーカー
CN102822201A (zh) * 2009-12-22 2012-12-12 罗切格利卡特公司 抗her3抗体及其用途

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WO2001077181A2 (fr) * 2000-04-12 2001-10-18 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Anticorps monoclonaux anti-rhesus d
CN101039958A (zh) * 2004-07-21 2007-09-19 格利科菲公司 含有主要是man3glcnac2糖形的免疫球蛋白
CN102822201A (zh) * 2009-12-22 2012-12-12 罗切格利卡特公司 抗her3抗体及其用途
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110724194A (zh) * 2018-07-17 2020-01-24 上海生物制品研究所有限责任公司 抗her3人源化单克隆抗体及其制剂
WO2024077775A1 (zh) * 2022-10-13 2024-04-18 深圳市百士通科技开发有限公司 一种多功能重组抗体及其制备方法和应用

Also Published As

Publication number Publication date
ES2905531T3 (es) 2022-04-11
BR112017023874A2 (pt) 2018-07-24
CA2985143C (en) 2023-10-17
JP2018515137A (ja) 2018-06-14
RS62912B1 (sr) 2022-03-31
US11001634B2 (en) 2021-05-11
EP3091033A1 (en) 2016-11-09
RU2017138468A3 (https=) 2019-09-03
US20180155433A1 (en) 2018-06-07
RU2017138468A (ru) 2019-06-06
JP6987742B2 (ja) 2022-01-05
EP3292154A1 (en) 2018-03-14
CA2985143A1 (en) 2016-11-10
PL3292154T3 (pl) 2022-04-19
WO2016177664A1 (en) 2016-11-10
PT3292154T (pt) 2022-01-26
EP3292154B1 (en) 2021-11-03

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Application publication date: 20180306