CN107714775A - A kind of handguard thimerosal - Google Patents
A kind of handguard thimerosal Download PDFInfo
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- CN107714775A CN107714775A CN201711056557.7A CN201711056557A CN107714775A CN 107714775 A CN107714775 A CN 107714775A CN 201711056557 A CN201711056557 A CN 201711056557A CN 107714775 A CN107714775 A CN 107714775A
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- oil
- thimerosal
- handguard
- glycerine
- alcohol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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Abstract
The present invention provides a kind of handguard thimerosal, and component includes alcohol, glycerine, tea tree ethereal oil, Herba Eupatorii Fortunei oil, caryophyllus oil, Scabrous Mosla Herb essential oil, eucalyptus robusta leaf oil, Herba Origani Vulgaris quintessence oil, allantoin, surfactant, acid-base modifier etc..Present invention reduces the alcohol concentration in traditional disinfection liquid, reduces the stimulation to skin, also improves the security used.The good plants essential oil of bactericidal effect is added, improves Disinfection Effect.A variety of essential oil compounds use, and sterilization has synergistic effect.Glycerine, plants essential oil have formula moisten effect in thimerosal, and allantoin promotes the healing of skin, remove downright bad material, and the present invention has good hand protecting function.
Description
Technical field
The present invention relates to a kind of thimerosal, more particularly to a kind of handguard thimerosal.
Background technology
When technical staff's progress Plant Tissue Breeding, cell culture etc. need the experiment of sterile working, it is necessary to keep hand
It is sterile, hand is carried out disinfection using 75% alcohol during routine operation, or rubber gloves is worn after washing one's hands.
Rubber gloves is airtight, and experimenter's hand is perspired or other malaise symptoms occurs, while is worn gloves and also reduced operation
Flexibility and fine degree.Therefore, although glove aseptic result is fine, many experimenters are reluctant to wear gloves.
It is the selection of most experimenter that hand, which is carried out disinfection, using 75% alcohol.But alcohol is irritating to the skin effect, warp
It is often uncomfortable using hand skin, reduce the wish that experimenter uses.
The Center for Disease Control recommends alcohol glycerine and wipes gimmick, takes the ml of 75% alcohol 90, the ml of glycerol adding 10, mixes
It is even to be placed in vial, it is made into 67.5% alcohol glycerine.In order to compare the sterilization effect that alcohol glycerine wipes gimmick and washing hand with soap method
Fruit, someone have done a check experiment.Everyone before operation after respectively do the Bacteria Culture of a finger.Alcohol glycerine wipes gimmick
The ml of 75% alcohol 90, the ml of glycerol adding 10 are taken, mixing is placed in vial, is made into 67.5% alcohol glycerine, immerses cotton balls 100,
Wiped all over full hand, about 1 minute, washing hand with soap method, washed one's hands with common laundry soap with this alcohol glycerine cotton balls during sterilization, Ran Houyong
Circulating water rinses, 2 times repeatedly, every time about 1 minute.2 groups of cultivation results：Alcohol glycerine group, positive bacterial culture 32 before hand is wiped,
Wherein staphylococcus aureus and hemolytic staphylococcus albus totally 12, all turns out cloudy after hand is wiped.Soap group is thin before washing one's hands
Bacterium culture is positive 34, wherein staphylococcus aureus and hemolytic staphylococcus albus totally 3, in the culture positive after washing one's hands
Turned out cloudy for 29 in 34, still there is 5 positives, wherein staphylococcus aureus 1.It is statistically analyzed, though two groups of differences do not show
Write but alcohol glycerine cotton balls wipes gimmick at least on Disinfection Effect unlike washing hand with soap method.
Alcohol content is high in alcohol glycerine thimerosal simultaneously, to hand skin irritatin.Experimenter usually uses alcolhol burner, high
Ignition phenomenon, calcination skin also easily occur for the alcoholic solution of content.
The content of the invention
To solve technical deficiency above, the invention provides a kind of handguard thimerosal, hand skin can be protected,
Improve Disinfection Effect.
The present invention is achieved by the following technical solutions：
A kind of handguard thimerosal, it is calculated in weight percent, including following components：
Alcohol 20-50%
Glycerine 5-10%
Tea tree ethereal oil 0.1-0.5%
Herba Eupatorii Fortunei oil 0.1-0.3%
Caryophyllus oil 0.1-0.2%
Scabrous Mosla Herb essential oil 0.1-0.2%
Eucalyptus robusta leaf oil 0.1-0.2%
Herba Origani Vulgaris quintessence oil 0.1-0.3%
Allantoin 0.01-0.3%
Surplus is the conventional auxiliary material such as water and surfactant, acid-base modifier.
Preferably, a kind of handguard thimerosal, it is calculated in weight percent, including following components：
Alcohol 20-40%
Glycerine 5-8%
Tea tree ethereal oil 0.2-0.5%
Herba Eupatorii Fortunei oil 0.2-0.3%
Caryophyllus oil 0.1-0.2%
Scabrous Mosla Herb essential oil 0.1-0.2%
Eucalyptus robusta leaf oil 0.1-0.2%
Herba Origani Vulgaris quintessence oil 0.2-0.3%
Allantoin 0.1-0.3%
Surplus is the conventional auxiliary material such as water and surfactant, acid-base modifier.
It is furthermore preferred that a kind of handguard thimerosal, calculated in weight percent, including following components：
Alcohol 25%
Glycerine 6%
Tea tree ethereal oil 0.3%
Herba Eupatorii Fortunei oil 0.2%
Caryophyllus oil 0.1%
Scabrous Mosla Herb essential oil 0.1%
Eucalyptus robusta leaf oil 0.2%
Herba Origani Vulgaris quintessence oil 0.3%
Allantoin 0.1%
Surplus is the conventional auxiliary material such as water and surfactant, acid-base modifier.
Thimerosal, which is prepared, takes normal temperature to be well mixed, and it is 7 to mix back end hydrogenation potassium oxide or hydrochloric acid adjustment PH.
Thimerosal use is soaked with cotton balls wipes hand, or takes and wash one's hands on a small quantity, or the mode such as hand immersion.
The beneficial effects of the invention are as follows：
1st, the alcohol concentration in traditional disinfection liquid is reduced, reduces the stimulation to skin, also improves the security used.
2nd, the good plants essential oil of bactericidal effect is added, improves Disinfection Effect.A variety of essential oil compounds use, sterilization tool
There is synergistic effect.
3rd, glycerine, plants essential oil have formula moisten effect in thimerosal, and allantoin promotes the healing of skin, removes necrosis
Material, the present invention have good hand protecting function.
Brief description of the drawings
Fig. 1 is Bactericidal test result, wherein 1,2,4 be handguard thimerosal, 3 be sterilized water.
Fig. 2 is Bactericidal test result, wherein 1,2,4 be handguard thimerosal, 3 be sterilized water.
Embodiment
Further detailed description is done to the present invention with reference to embodiment：
The preparation of the handguard thimerosal of embodiment 1
Following components is taken according to percentage by weight：
Alcohol 50%
Glycerine 10%
Tea tree ethereal oil 0.5%
Herba Eupatorii Fortunei oil 0.3%
Caryophyllus oil 0.2%
Scabrous Mosla Herb essential oil 0.2%
Eucalyptus robusta leaf oil 0.2%
Herba Origani Vulgaris quintessence oil 0.3%
Allantoin 0.3%
Span-60 2%
Tween-60 1.3%
Surplus is water.
It is 7 to mix back end hydrogenation potassium oxide or hydrochloric acid adjustment PH.
The preparation of the handguard thimerosal of embodiment 2
Handguard thimerosal is prepared, it is calculated in weight percent, including following components：
Alcohol 20%
Glycerine 5%
Tea tree ethereal oil 0.1%
Herba Eupatorii Fortunei oil 0.1%
Caryophyllus oil 0.1%
Scabrous Mosla Herb essential oil 0.1%
Eucalyptus robusta leaf oil 0.1%
Herba Origani Vulgaris quintessence oil 0.1%
Allantoin 0.01%
Surplus is water.
It is 7 to mix back end hydrogenation potassium oxide or hydrochloric acid adjustment PH.
The preparation of the handguard thimerosal of embodiment 3
Alcohol 40%
Glycerine 8%
Tea tree ethereal oil 0.5%
Herba Eupatorii Fortunei oil 0.3%
Caryophyllus oil 0.2%
Scabrous Mosla Herb essential oil 0.2%
Eucalyptus robusta leaf oil 0.2%
Herba Origani Vulgaris quintessence oil 0.3%
Allantoin 0.3%
Surplus is water.
It is 7 to mix back end hydrogenation potassium oxide or hydrochloric acid adjustment PH.
The preparation of the handguard thimerosal of embodiment 4
Handguard thimerosal is prepared, it is calculated in weight percent, including following components：
Alcohol 30%
Glycerine 7%
Tea tree ethereal oil 0.4%
Herba Eupatorii Fortunei oil 0.3%
Caryophyllus oil 0.1%
Scabrous Mosla Herb essential oil 0.2%
Eucalyptus robusta leaf oil 0.1%
Herba Origani Vulgaris quintessence oil 0.2%
Allantoin 0.2%
Surplus is water.
It is 7 to mix back end hydrogenation potassium oxide or hydrochloric acid adjustment PH.
The preparation of the handguard thimerosal of embodiment 5
Handguard thimerosal is prepared, it is calculated in weight percent, including following components：
Alcohol 25%
Glycerine 6%
Tea tree ethereal oil 0.3%
Herba Eupatorii Fortunei oil 0.2%
Caryophyllus oil 0.1%
Scabrous Mosla Herb essential oil 0.1%
Eucalyptus robusta leaf oil 0.2%
Herba Origani Vulgaris quintessence oil 0.3%
Allantoin 0.1%
Surplus is water.
It is 7 to mix back end hydrogenation potassium oxide or hydrochloric acid adjustment PH.
The antibacterial effect of embodiment 6 is tested
According to light industry standard QB/T 2738-2012《The evaluation method of daily chemical products antibacterial bacteriostatic effect》The suspension of offer is determined
Amount method carries out antibacterial experiment, and experimental result is shown in Table 1：
The handguard thimerosal bacteriostatic experiment of table 1
As it can be seen from table 1 handguard thimerosal antibacterial effect is good, meet light industry standard GB/T 2850-2007《Antibacterial
Antibacterial type detergent》Antibacterial reach approximately equal to 90% standard.
The effect of embodiment 1 to embodiment 5 meets industry requirement, may have benefited from the plants essential oil interaction of addition
Synergistic effect, the reduction of alcohol concentration, do not reduce antibacterial effect.The effect of embodiment 4 is especially good, may be between essential oil
Synergistic effect is more preferable during appropriate proportioning.
The Bactericidal test of embodiment 7
Strains tested is staphylococcus aureus (Staphylococcus aureus), Escherichia coli (Escherichia
Coli), using beef-protein medium culture.
Bacteriostatic activity is determined using Odontothrips loti.The various mL of bacteria suspension 0.1 to be measured of 2.0 × 108 CFU/mL are taken,
It is coated on corresponding solidification flat board, each flat board is put into 4 sterilizing Oxford cups afterwards, wherein 1 is used as control (with sterile
Water is control).Hand cleanser is taken to add in Oxford cup with liquid-transfering gun respectively, 37 DEG C of 24 h of culture of bacterium remove Oxford cup, survey
Determine antibacterial circle diameter, every group parallel 3 times, take its average value.Experimental result is shown in Table 2, Fig. 1 and Fig. 2.
The handguard thimerosal Bactericidal test of table 2
According to Ministry of Health of the People's Republic of China《Disinfection technology standard》Judgement to bacteriostasis：Antibacterial circle diameter is less than or waited
In 7 mm persons, no bacteriostasis is judged to；Antibacterial circle diameter is more than 7 mm persons, there is weak bacteriostasis；Inhibition zone in 10-20 mm persons,
There is moderate antibacterial effect；Antibacterial circle diameter is more than 20 mm persons, there is strong bacteriostasis.As shown in Table 2, the present invention has bacteriostasis.
The handguard effect experiment of embodiment 8
This experiments experiment personnel 7, the man of 5 female 2, using handguard thimerosal of the present invention 1 week, hand skin was felt good, skin taste
Profit, fine and smooth, the chapped phenomenon of hand is reduced, and glycerine and plants essential oil have moist function to skin, and allantoin can repair the small damage of skin
Lose, it is beneficial to skin repair.7 experimenters are more likely to the handguard thimerosal using the present invention.
Described above is only the preferred embodiment of this patent, it is noted that for the ordinary skill people of the art
For member, on the premise of the art of this patent principle is not departed from, some improvement and replacement can also be made, these improve and replaced
Also it should be regarded as the protection domain of this patent.
Claims (5)
1. a kind of handguard thimerosal, calculated in weight percent, including following components：
Alcohol 20-50%
Glycerine 5-10%
Tea tree ethereal oil 0.1-0.5%
Herba Eupatorii Fortunei oil 0.1-0.3%
Caryophyllus oil 0.1-0.2%
Scabrous Mosla Herb essential oil 0.1-0.2%
Eucalyptus robusta leaf oil 0.1-0.2%
Herba Origani Vulgaris quintessence oil 0.1-0.3%
Allantoin 0.01-0.3%
Surplus is the conventional auxiliary material such as water and surfactant, acid-base modifier.
2. a kind of handguard thimerosal according to claim 1, calculated in weight percent, including following components：
Alcohol 20-40%
Glycerine 5-8%
Tea tree ethereal oil 0.2-0.5%
Herba Eupatorii Fortunei oil 0.2-0.3%
Caryophyllus oil 0.1-0.2%
Scabrous Mosla Herb essential oil 0.1-0.2%
Eucalyptus robusta leaf oil 0.1-0.2%
Herba Origani Vulgaris quintessence oil 0.2-0.3%
Allantoin 0.1-0.3%
Surplus is the conventional auxiliary material such as water and surfactant, acid-base modifier.
3. a kind of handguard thimerosal according to claim 2, calculated in weight percent, including following components：
Alcohol 25%
Glycerine 6%
Tea tree ethereal oil 0.3%
Herba Eupatorii Fortunei oil 0.2%
Caryophyllus oil 0.1%
Scabrous Mosla Herb essential oil 0.1%
Eucalyptus robusta leaf oil 0.2%
Herba Origani Vulgaris quintessence oil 0.3%
Allantoin 0.1%
Surplus is the conventional auxiliary material such as water and surfactant, acid-base modifier.
4. a kind of handguard thimerosal according to any one of claim 1-3, described thimerosal, which is prepared, takes normal temperature to mix
Close uniformly, it is 7 to mix back end hydrogenation potassium oxide or hydrochloric acid adjustment PH.
5. a kind of handguard thimerosal according to claim 4, described thimerosal use is soaked with cotton balls wipes hand, or takes few
Amount is washed one's hands, or the mode such as hand immersion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711056557.7A CN107714775A (en) | 2017-11-01 | 2017-11-01 | A kind of handguard thimerosal |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711056557.7A CN107714775A (en) | 2017-11-01 | 2017-11-01 | A kind of handguard thimerosal |
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| CN107714775A true CN107714775A (en) | 2018-02-23 |
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| CN201711056557.7A Pending CN107714775A (en) | 2017-11-01 | 2017-11-01 | A kind of handguard thimerosal |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109247343A (en) * | 2018-11-20 | 2019-01-22 | 娇时日化（杭州）股份有限公司 | A kind of thimerosal and preparation method thereof containing tea tree ethereal oil |
| CN109512741A (en) * | 2018-12-26 | 2019-03-26 | 株洲千金药业股份有限公司 | A kind of essential oil is washed one's hands condensation and preparation method thereof |
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| CN102239893A (en) * | 2011-05-04 | 2011-11-16 | 云南同方科技有限公司 | Plant essential oil bactericidal disinfectant |
| CN104840378A (en) * | 2015-05-28 | 2015-08-19 | 南阳市汇博生物技术有限公司 | Skin-care sterilization hand sanitizer and preparation method thereof |
| CN106309273A (en) * | 2016-08-25 | 2017-01-11 | 攀柔莎（江苏）生物科技股份有限公司 | Skin care leave-in liquid soap |
| CN106577797A (en) * | 2015-10-20 | 2017-04-26 | 青岛益邦瑞达生物科技有限公司 | Preparation method of plant disinfectant |
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2017
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| CN102036691A (en) * | 2008-04-24 | 2011-04-27 | 桑尼维普斯Pty有限公司 | Disinfecting formulation |
| CN102239893A (en) * | 2011-05-04 | 2011-11-16 | 云南同方科技有限公司 | Plant essential oil bactericidal disinfectant |
| CN104840378A (en) * | 2015-05-28 | 2015-08-19 | 南阳市汇博生物技术有限公司 | Skin-care sterilization hand sanitizer and preparation method thereof |
| CN106577797A (en) * | 2015-10-20 | 2017-04-26 | 青岛益邦瑞达生物科技有限公司 | Preparation method of plant disinfectant |
| CN106309273A (en) * | 2016-08-25 | 2017-01-11 | 攀柔莎（江苏）生物科技股份有限公司 | Skin care leave-in liquid soap |
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| 周静怡等: "酒精甘油消毒液用于重症监护室护士手消毒效果探讨", 《护理研究》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109247343A (en) * | 2018-11-20 | 2019-01-22 | 娇时日化（杭州）股份有限公司 | A kind of thimerosal and preparation method thereof containing tea tree ethereal oil |
| CN109512741A (en) * | 2018-12-26 | 2019-03-26 | 株洲千金药业股份有限公司 | A kind of essential oil is washed one's hands condensation and preparation method thereof |
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Application publication date: 20180223 |