CN107712899A - 一种复方山茶油软胶囊及其制备方法 - Google Patents
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Abstract
本发明公开了一种复方山茶油软胶囊及其制备方法，属于医药保健品技术领域，该复方山茶油软胶囊以1~3重量份山茶油、3~5重量份灵芝孢子油、3~5重量份角鲨烯为主药构成囊心液，并以2~6重量份明胶、1~4重量份甘油、1~5重量份水为辅料构成囊衣，所得软胶囊不仅制剂成型性良好，且具有良好抗疲劳功效。
Description
技术领域
本发明属于医药保健品技术领域，具体涉及一种复方山茶油软胶囊及其制备方法。
背景技术
随着生活节奏的加快和社会压力的增大，许多人处于亚健康状态，如经常出现疲劳感、倦怠感、注意力涣散、身体不适等。如果长期在此状态下生活工作，症状也将进一步恶化，从而给个人、家庭、社会造成严重影响和负担。对已进入或即将进入亚健康状态者，通过必要的饮食、锻炼、心理等调养，防患于未然，已引起人们的高度重视。
山茶油是我国特有的木本油脂，自古有“油中之王”和“食疗珍品”之称，被誉为“东方橄榄油”，并被联合国粮农组织推荐为健康食品。山茶油营养丰富，不仅富含油酸、亚油酸，而且还含有具有生物活性的微量物质，如角鲨烯、多酚类物质、黄酮类化合物（山茶苷和茶皂素）、三萜皂苷（山茶皂苷等）、维生素E、植物甾醇、磷脂质、鞣质、维生素K、维生素D、β-胡萝卜素、茶多糖和各种微量元素，其中以角鲨烯为代表的多酚类活性成分有很好的富氧能力，可抗缺氧和抗疲劳，且具有提高人体免疫力及增进胃肠道吸收等功能。
灵芝孢子油有鼓舞气血之能，能调和营卫之气。现代研究表明，灵芝孢子油对人体免疫功能有明显的增强作用，灵芝孢子油对二苯代苦味肼基自由基（DPPH·）、超氧阴离子自由基（O2-·）及羟基自由基（OH·）有清除作用，且清除能力随浓度的增加而增强，其中以清除OH·的效果最好；同时灵芝孢子油具有抗油脂氧化能力。
发明内容
本发明的目的在于提供一种复方山茶油软胶囊及其制备方法，所得复方山茶油软胶囊不仅制剂成型性良好，且具有良好抗疲劳的保健功效。
为实现上述目的，本发明采用如下技术方案：
一种复方山茶油软胶囊，其所用主药按重量份计为：山茶油1~3份、灵芝孢子油3~5份、角鲨烯3~5份；所用辅料按重量份计包括：明胶2~6份、甘油1~4份、水1~5份。
所述复方山茶油软胶囊的制备方法包括如下步骤：
1）按比例取灵芝孢子油和山茶油，先将灵芝孢子油加入部分山茶油中，加热搅拌使其充分溶解，放冷后加入剩余山茶油和角鲨烯混合均匀，制成微黄色油性囊心液，备用；
2）按比例取明胶、甘油和水，先将明胶置于部分水中使其充分溶胀后，加热使其溶解，然后加入甘油及剩余水，50℃~80℃保温搅拌混合均匀，再经静置脱泡、过滤，得胶液备用；
3）将所得囊心液和胶液上机制成胶丸，在转笼中用冷风固化成型后，用乙醇洗去表面油层，再于20～40℃热风干燥，即得所述复方山茶油软胶囊。
本发明的显著优点在于：山茶油抗缺氧和抗疲劳功能突出，灵芝孢子油则在增强免疫力方面功能较突出。由于疲劳状态往往伴随免疫力低下，本发明采用山茶油与灵芝孢子油、角鲨烯配方，利用三者在保健功能上的互补性，制备具有良好抗疲劳功效的保健胶囊。且山茶油与灵芝孢子油均为天然植物油类原料，理化性质接近，相容性好。
同时，本发明选择软胶囊剂型，是由于其可最大限度保留挥发性有效成分，适用于含有天然植物油成分的装载，且其进入胃肠能迅速崩解而被人体吸收起效。
此外，本发明将灵芝孢子油逐步用山茶油进行稀释，不仅易于其混合均匀，还可提高制剂的成型性。试验表明，制备出的软胶囊成品色泽透明，外观整洁，无黏结、变形、渗漏或囊壳破裂等现象。
具体实施方式
为了使本发明所述的内容更加便于理解，下面结合具体实施方式对本发明所述的技术方案做进一步的说明，但是本发明不仅限于此。
实施例1
1）取灵芝孢子油3重量份、山茶油1重量份、角鲨烯3重量份，先将灵芝孢子油加入0.5重量份山茶油中，加热搅拌使其充分溶解，放冷后加入剩余山茶油和角鲨烯混合均匀，制成微黄色油性囊心液，备用；
2）取明胶2重量份、甘油1重量份和水1重量份，先将明胶置于0.5重量份水中使其充分溶胀后，加热使其溶解，然后加入甘油及剩余水，50℃保温搅拌混合均匀，再经静置脱泡、过滤，得胶液备用；
3）将所得囊心液和胶液上机制成胶丸，在转笼中用冷风固化成型后，用乙醇洗去表面油层，再于20℃热风干燥，即得所述复方山茶油软胶囊。
实施例2
1）取灵芝孢子油4重量份、山茶油2重量份、角鲨烯4重量份，先将肉桂油加入1重量份山茶油中，加热搅拌使其充分溶解，放冷后加入剩余山茶油和角鲨烯混合均匀，制成微黄色油性囊心液，备用；
2）取明胶4重量份、甘油2重量份和水4重量份，先将明胶置于2重量份水中使其充分溶胀后，加热使其溶解，然后加入甘油及剩余水，60℃保温搅拌混合均匀，再经静置脱泡、过滤，得胶液备用；
3）将所得囊心液和胶液上机制成胶丸，在转笼中用冷风固化成型后，用乙醇洗去表面油层，再于30℃热风干燥，即得所述复方山茶油软胶囊。
实施例3
1）取灵芝孢子油5重量份、山茶油3重量份、角鲨烯5重量份，先将灵芝孢子油加入2重量份山茶油中，加热搅拌使其充分溶解，放冷后加入剩余山茶油和角鲨烯混合均匀，制成微黄色油性囊心液，备用；
2）取明胶6重量份、甘油4重量份和水5重量份，先将明胶置于4重量份水中使其充分溶胀后，加热使其溶解，然后加入甘油及剩余水，80℃保温搅拌混合均匀，再经静置脱泡、过滤，得胶液备用；
3）将所得囊心液和胶液上机制成胶丸，在转笼中用冷风固化成型后，用乙醇洗去表面油层，再于40℃热风干燥，即得所述复方山茶油软胶囊。
小鼠耐缺氧时间可作为判断小鼠体力强壮程度、抗疲劳能力的客观指标之一。将实施例1所得复方山茶油软胶囊分为低、中、高3个不同剂量组进行动物实验，结果显示，小鼠常压耐缺氧时间分别延长8%（p＜0.05）、15%（p＜0.01）和19%（p＜0.01），其中以高剂量组最为明显。
小鼠负重游泳时间可作为判断小鼠体力强壮程度、抗疲劳能力的客观指标之一。将实施例1所得复方山茶油软胶囊分为低、中、高3个不同剂量组进行动物实验，结果显示，负重小鼠的游泳时间分别延长6%（p＞0.05）、13%（p＜0.01）和11%（p＜0.01），其中以中剂量组最为明显。
由此可见，本发明复方山茶油软胶囊具有较显著的抗疲劳保健功能。
以上所述仅为本发明的较佳实施例，凡依本发明申请专利范围所做的均等变化与修饰，皆应属本发明的涵盖范围。
Claims (2)
1.一种复方山茶油软胶囊，其特征在于：所用主药按重量份计为：山茶油1~3份、灵芝孢子油3~5份、角鲨烯3~5份；
所用辅料按重量份计包括：明胶2~6份、甘油1~4份、水1~5份。
2.一种如权利要求1所述复方山茶油软胶囊的制备方法，其特征在于：包括如下步骤：
1）按比例取灵芝孢子油和山茶油，先将灵芝孢子油加入部分山茶油中，加热搅拌使其充分溶解，放冷后加入剩余山茶油和角鲨烯混合均匀，制成微黄色油性囊心液，备用；
2）按比例取明胶、甘油和水，先将明胶置于部分水中使其充分溶胀后，加热使其溶解，然后加入甘油及剩余水，50℃~80℃保温搅拌混合均匀，再经静置脱泡、过滤，得胶液备用；
3）将所得囊心液和胶液上机制成胶丸，在转笼中用冷风固化成型后，用乙醇洗去表面油层，再于20～40℃热风干燥，即得所述复方山茶油软胶囊。
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| CN109430847A (zh) * | 2018-12-04 | 2019-03-08 | 安徽省金天柱农业科技有限公司 | 一种茶油软胶囊及其制备方法 |
| CN110393759A (zh) * | 2019-08-15 | 2019-11-01 | 赖科良 | 一种山茶油保健胶囊及其制备方法 |
| CN111437320A (zh) * | 2020-05-18 | 2020-07-24 | 德化县仙铭生态农林有限公司 | 一种高效抑菌的灵芝三萜茶油胶囊及其制备工艺 |
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