CN107709545A - 从干细胞生成肌肉谱系细胞 - Google Patents

从干细胞生成肌肉谱系细胞 Download PDF

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CN107709545A
CN107709545A CN201680035069.5A CN201680035069A CN107709545A CN 107709545 A CN107709545 A CN 107709545A CN 201680035069 A CN201680035069 A CN 201680035069A CN 107709545 A CN107709545 A CN 107709545A
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cell
pluripotent stem
satellite
pax3
pax7
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乌利·施密特
莱斯利·卡伦
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Sonic Master Ltd
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Gina Intellectual Property Holdings Pte Ltd
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    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0658Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0658Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
    • C12N5/0659Satellite cells
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5061Muscle cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48Reproductive organs
    • A61K35/54Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/15Transforming growth factor beta (TGF-β)
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
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CN201680035069.5A 2015-04-22 2016-04-22 从干细胞生成肌肉谱系细胞 Pending CN107709545A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562151352P 2015-04-22 2015-04-22
US62/151,352 2015-04-22
PCT/AU2016/000144 WO2016168890A1 (en) 2015-04-22 2016-04-22 Generation of muscle-lineage cells from stem cells

Publications (1)

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CN107709545A true CN107709545A (zh) 2018-02-16

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US (1) US20180346879A1 (enExample)
EP (1) EP3286301B1 (enExample)
JP (1) JP7055638B2 (enExample)
CN (1) CN107709545A (enExample)
AU (1) AU2016250905B2 (enExample)
CA (1) CA2983332A1 (enExample)
WO (1) WO2016168890A1 (enExample)

Cited By (1)

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CN110859854A (zh) * 2018-08-08 2020-03-06 上海市东方医院 治疗神经源性肌肉萎缩的药物组合物及其制法和应用

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RU2734770C2 (ru) 2014-11-21 2020-10-23 Регенерон Фармасьютикалз, Инк. Способы и композиции для нацеленной генетической модификации с использованием парных гидовых рнк
WO2017100498A1 (en) * 2015-12-11 2017-06-15 The Johns Hopkins University Isolation of fusion-competent myoblasts and therapeutic applications thereof related to muscular dystrophy
US20190338251A1 (en) * 2016-04-27 2019-11-07 Takeda Pharmaceutical Company Limited Skeletal Muscle Precursor Cells and Production Method for Skeletal Muscle Cells
EP4368637A3 (en) 2016-05-20 2024-07-10 Regeneron Pharmaceuticals, Inc. Methods for breaking immunological tolerance using multiple guide rnas
CN110730819A (zh) 2016-10-26 2020-01-24 索尼克马斯特有限公司 肌肉谱系细胞的改善产生及其治疗用途
EP3565887B1 (en) 2017-01-06 2025-07-16 The Regents of The University of California Methods for generating skeletal muscle progenitor cells
CN107937338B (zh) * 2017-11-30 2021-08-03 中山大学 一种来自多能干细胞的中胚层谱系间充质干细胞及其制备方法
JP7033095B2 (ja) * 2019-03-04 2022-03-09 日清食品ホールディングス株式会社 三次元筋組織とその製造方法
US20220411825A1 (en) * 2019-11-20 2022-12-29 Vita Therapeutics, Inc. Method of engineering hypoimmunogenic muscle precursor cells
JP7540893B2 (ja) * 2020-02-27 2024-08-27 テルモ株式会社 Cd56陽性細胞の比率を高めるための組成物
CN111826451A (zh) * 2020-09-11 2020-10-27 中国肉类食品综合研究中心 实时荧光定量pcr检测猪肌肉调节因子的引物组及其应用
WO2022093665A1 (en) * 2020-10-26 2022-05-05 University Of Massachusetts Methods and compositions for treatment of muscle disease with ipsc-induced human skeletal muscle stem cells
WO2022140300A1 (en) * 2020-12-22 2022-06-30 Ixcells Biotechnolgies Usa, Inc. Methods and compositions for differentiating skeletal muscle
US20240360415A1 (en) * 2021-08-09 2024-10-31 Aleph Farms Ltd. Muscle cells differentiated from pluripotent cells, methods of producing same and use thereof
KR20240152443A (ko) * 2023-04-12 2024-10-22 이엔셀 주식회사 근력 약화 관련 질환 치료제 스크리닝 방법

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Publication number Priority date Publication date Assignee Title
CN110859854A (zh) * 2018-08-08 2020-03-06 上海市东方医院 治疗神经源性肌肉萎缩的药物组合物及其制法和应用

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JP7055638B2 (ja) 2022-04-18
EP3286301A1 (en) 2018-02-28
WO2016168890A1 (en) 2016-10-27
AU2016250905B2 (en) 2022-02-10
EP3286301B1 (en) 2021-07-28
JP2018518943A (ja) 2018-07-19
CA2983332A1 (en) 2016-10-27
AU2016250905A8 (en) 2018-03-15
EP3286301A4 (en) 2019-02-20
AU2016250905A1 (en) 2017-11-09
US20180346879A1 (en) 2018-12-06
WO2016168890A8 (en) 2017-11-30

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