CN107693412A - A kind of antibacterial skin moistening liquid soap and preparation method thereof - Google Patents
A kind of antibacterial skin moistening liquid soap and preparation method thereof Download PDFInfo
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- CN107693412A CN107693412A CN201710877978.XA CN201710877978A CN107693412A CN 107693412 A CN107693412 A CN 107693412A CN 201710877978 A CN201710877978 A CN 201710877978A CN 107693412 A CN107693412 A CN 107693412A
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- seed oil
- extract
- skin moistening
- liquid soap
- antibacterial skin
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- 239000007788 liquid Substances 0.000 title claims abstract description 54
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 29
- 239000000344 soap Substances 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 239000000284 extract Substances 0.000 claims abstract description 44
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 42
- 235000003130 Arctium lappa Nutrition 0.000 claims abstract description 24
- 235000005979 Citrus limon Nutrition 0.000 claims abstract description 24
- 244000131522 Citrus pyriformis Species 0.000 claims abstract description 24
- 235000008078 Arctium minus Nutrition 0.000 claims abstract description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000008367 deionised water Substances 0.000 claims abstract description 19
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 19
- 239000009806 pulsatillae Substances 0.000 claims abstract description 19
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims abstract description 13
- 229940069338 potassium sorbate Drugs 0.000 claims abstract description 13
- 235000010241 potassium sorbate Nutrition 0.000 claims abstract description 13
- 239000004302 potassium sorbate Substances 0.000 claims abstract description 13
- 229940057950 sodium laureth sulfate Drugs 0.000 claims abstract description 12
- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 11
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 9
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 9
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 9
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims abstract description 7
- 240000005528 Arctium lappa Species 0.000 claims abstract description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 24
- 241000208843 Arctium Species 0.000 claims description 20
- 238000003756 stirring Methods 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 14
- 238000000605 extraction Methods 0.000 claims description 13
- 239000000706 filtrate Substances 0.000 claims description 12
- 238000010992 reflux Methods 0.000 claims description 8
- 239000000341 volatile oil Substances 0.000 claims description 8
- 238000011049 filling Methods 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 230000001954 sterilising effect Effects 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 5
- 238000001256 steam distillation Methods 0.000 claims description 5
- 238000002137 ultrasound extraction Methods 0.000 claims description 5
- 241001504477 Pycnonotidae Species 0.000 claims description 4
- 241000522190 Desmodium Species 0.000 claims description 3
- 125000002252 acyl group Chemical group 0.000 claims description 2
- 239000003921 oil Substances 0.000 claims description 2
- 235000019198 oils Nutrition 0.000 claims description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 244000025254 Cannabis sativa Species 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 1
- 239000010931 gold Substances 0.000 claims 1
- 229910052737 gold Inorganic materials 0.000 claims 1
- 238000002604 ultrasonography Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 15
- 238000004140 cleaning Methods 0.000 abstract description 4
- 230000007774 longterm Effects 0.000 abstract description 3
- 239000000126 substance Substances 0.000 abstract description 3
- 241000233866 Fungi Species 0.000 abstract 1
- 230000003020 moisturizing effect Effects 0.000 abstract 1
- 230000000452 restraining effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 description 6
- 235000013162 Cocos nucifera Nutrition 0.000 description 4
- 244000060011 Cocos nucifera Species 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 229960003237 betaine Drugs 0.000 description 4
- 230000002354 daily effect Effects 0.000 description 4
- 238000005202 decontamination Methods 0.000 description 4
- 230000003588 decontaminative effect Effects 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 230000001408 fungistatic effect Effects 0.000 description 4
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 4
- -1 oleoyl amine Chemical class 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 2
- 238000009833 condensation Methods 0.000 description 2
- 230000005494 condensation Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 235000007421 Mentha citrata Nutrition 0.000 description 1
- 244000007703 Mentha citrata Species 0.000 description 1
- 235000008660 Mentha x piperita subsp citrata Nutrition 0.000 description 1
- 101001031591 Mus musculus Heart- and neural crest derivatives-expressed protein 2 Proteins 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000001775 anti-pathogenic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 238000003501 co-culture Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 231100001261 hazardous Toxicity 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 229940105902 mint extract Drugs 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
- Detergent Compositions (AREA)
Abstract
The present invention relates to a kind of antibacterial skin moistening liquid soap and preparation method thereof, belong to daily use chemicals technical field.The hand cleanser is made by following raw material, and each raw material and its mass percent are：The lemon seed oil 8% 12%, burdock seed oil 4% 6%, Herba Lysimachiae extract 6% 8%, Radix Pulsatillae extract 2% 4%, sodium laureth sulfate 10% 14%, Cocoamidopropyl betaine 8% 10%, hyaluronic acid 1% 3%, potassium sorbate 0.1% 0.3%, surplus is deionized water.Antibacterial skin moistening liquid soap each component synergy of the present invention, cleaning effect is good, and scope of restraining fungi is wide, small to skin side-effects, while also has moisturizing moisture-keeping function, can be long-term use of.
Description
Technical field
The present invention relates to a kind of antibacterial skin moistening liquid soap and preparation method thereof, belong to daily use chemicals technical field.
Background technology
Hand cleanser is a kind of common daily cleaning articles for use, as the improvement of people's living standards, washing shield to hand cleanser etc.
The requirement more and more higher of articles for use, past, people have only required cleaning decontamination to hand cleanser, gradually, with health of people
The lifting of consciousness, it is believed that hand cleanser must be with antibacterial disinfective action, then in the market appearance except with cleaning action
Large quantities of hand cleanser with decontamination bacteriostasis, but the decontamination composition in these hand cleanser is mostly by the compound with phenyl ring
It is made, antipathogenic composition is the broad-spectrum antibacterial agent of synthesis mostly, chemical substance be present and easily remains, dry skin, and biocidal property is unstable
It is fixed, it is the shortcomings of antibacterial time is short, long-term use of, skin can be caused potentially hazardous, and many natural extracts have decontamination
It is antibacterial to wait effect, and Small side effects, therefore the green antibacterial skin moistening liquid soap for adding natural extract turns into a kind of trend.
The content of the invention
It is an object of the invention to provide a kind of antibacterial skin moistening liquid soap, the hand cleanser is made by following raw material, each original
Material and its mass percent are：The lemon seed oil 8%-12%, burdock seed oil 4%-6%, Herba Lysimachiae extract 6%-8%, Chinese bulbul extraction
Thing 2%-4%, sodium laureth sulfate 10%-14%, Cocoamidopropyl betaine 8%-10%, hyaluronic acid 1%-3%, potassium sorbate
0.1%-0.3%, surplus are deionized water, and the mass percent sum of all raw materials is 100%.
The lemon seed oil of the present invention, burdock seed oil, Herba Lysimachiae extract, Radix Pulsatillae extract are prepared into according to a conventional method
Arrive.
Preferably, the lemon seed oil of the present invention is made by the following method：It is 3- that dry lemon seed is crushed into particle diameter
4mm, the 8-12 times of deionized water measured is added, ultrasonic extraction 28-32min, standby in the case where frequency is 48-50KHz, is steamed with vapor
Volatile oil is collected after evaporating method extraction 3-4h, produces the lemon seed oil.
Preferably, burdock seed oil of the present invention is made by the following method：Dry great burdock achene seed is crushed into particle diameter is
3-4mm, the 10-12 times of deionized water measured is added, ultrasonic extraction 46-50min, standby in the case where frequency is 44-48KHz, is steamed with water
Volatile oil is collected after steam distillation method extraction 3.8-4.2h, produces burdock seed oil.
Preferably, Herba Lysimachiae extract of the present invention is made by the following method：Desmodium herb is taken, cleans drying,
Shredded, then the 13-15 times of 70%-80% measured of addition ethanol, constant temperature refluxing extraction 2-3 times at 58-62 DEG C, every time
1.5-2.5h, filtering, merging filtrate, concentration filtrate is evaporated under reduced pressure under 38-42 DEG C of constant temperature with Rotary Evaporators, reclaims ethanol,
Thick liquid is obtained, thick liquid is dried in vacuo at 28-32 DEG C, produces Herba Lysimachiae extract.
Preferably, Radix Pulsatillae extract of the present invention is made by the following method：The root of the Chinese bulbul is taken, cleans drying,
Shredded, then the 11-13 times of 75%-85% measured of addition ethanol, constant temperature refluxing extraction 2-3 times at 50 DEG C -60 DEG C, every time
2.4-2.6h, filtering, merging filtrate, concentration filtrate is evaporated under reduced pressure under 36-40 DEG C of constant temperature with Rotary Evaporators, reclaims ethanol,
Thick liquid is obtained, thick liquid is dried in vacuo at 27-29 DEG C, produces Radix Pulsatillae extract.
Another object of the present invention is to provide a kind of preparation method of described antibacterial skin moistening liquid soap, specifically include with
Lower step：
（1）Deionized water is heated to 85-95 DEG C, then adds sodium laureth sulfate, 5-7min is stirred, adds cocounut oil acyl
Amine CAB, continue to stir 7-9 minutes to uniform.
（2）Herba Lysimachiae extract, Radix Pulsatillae extract are added to step（1）Liquid in, continue stir 3-5min.
（3）Then the lemon seed oil, burdock seed oil are added to step（2）Liquid in, continue stir 2-3min.
（4）Hyaluronic acid and potassium sorbate are eventually adding, is stirred, is cooled to normal temperature, it is filling after sterilizing.
Beneficial effects of the present invention：
（1）Hand cleanser of the present invention adds a variety of natural extracts, small to skin side-effects, is adapted to long-term safety to use.
（2）A variety of natural extracts are with the addition of in hand cleanser of the present invention, make it have clean skin, convergence, Bergamot Mint Extract,
The effect such as effect, also good inhibiting bacteria and diminishing inflammation such as skin whitening, increase skin shine.
（3）The natural extract raw material of hand cleanser addition of the present invention, wide material sources, scientific matching, economical and practical effect are good.
Embodiment
The present invention is described in further detail with reference to specific embodiment, but protection scope of the present invention is not limited to
The content.
The lemon seed oil described in the embodiment of the present invention 1 ~ 4 is made by the following method：Dry lemon seed is crushed into particle diameter is
3.5mm, the deionized water of 10 times of amounts is added, ultrasonic extraction 30min, standby in the case where frequency is 49KHz, installs determination of volatile oil
Device and condensation reflux unit, with volatile oil is collected after extraction by steam distillation 3.5h, produce the lemon seed oil.
Burdock seed oil described in the embodiment of the present invention 1 ~ 4 is made by the following method：Dry great burdock achene seed is crushed to grain
Footpath is 3.5mm, adds the deionized water of 11 times of amounts, and in the case where frequency is 46KHz, ultrasonic extraction 48min, standby, installs volatile oil
Analyzer and condensation reflux unit, with volatile oil is collected after extraction by steam distillation 4h, produce burdock seed oil.
Herba Lysimachiae extract described in the embodiment of the present invention 1 ~ 4 is made by the following method：Desmodium herb is taken, cleans and dries
It is dry, shredded, be put into round flask, then 75% ethanol of 14 times of amounts of addition, constant temperature refluxing extraction 3 times at 60 DEG C,
Each 2h, filtering, merging filtrate, concentration filtrate is evaporated under reduced pressure under 40 DEG C of constant temperature with Rotary Evaporators, reclaims ethanol, obtains thick
Shape liquid, thick liquid is dried in vacuo at 30 DEG C, produces Herba Lysimachiae extract.
Radix Pulsatillae extract described in the embodiment of the present invention 1 ~ 4 is made by the following method：The root of the Chinese bulbul is taken, cleans and dries
It is dry, shredded, be put into round flask, then 80% ethanol of 12 times of amounts of addition, constant temperature refluxing extraction 3 times at 55 DEG C,
Each 2.5h, filtering, merging filtrate, concentration filtrate is evaporated under reduced pressure under 38 DEG C of constant temperature with Rotary Evaporators, reclaims ethanol, obtains
Thick liquid, thick liquid is dried in vacuo at 28 DEG C, produces Radix Pulsatillae extract.
Embodiment 1
A kind of antibacterial skin moistening liquid soap described in the present embodiment, each material quality percentage are：The lemon seed oil 10%, burdock seed oil
4%, Herba Lysimachiae extract 7%, Radix Pulsatillae extract 2%, sodium laureth sulfate 12%, Cocoamidopropyl betaine 9% is transparent
Matter acid 3%, potassium sorbate 0.1%, surplus are deionized water, and the mass percent sum of all raw materials is 100%.
A kind of preparation method of antibacterial skin moistening liquid soap described in the present embodiment comprises the following steps：
（1）Deionized water is heated to 85 DEG C, then adds sodium laureth sulfate, 7min is stirred, adds coconut oleoyl amine third
Base glycine betaine, continue stirring 7 minutes to uniform.
（2）Herba Lysimachiae extract, Radix Pulsatillae extract are added to step（1）Liquid in, continue stir 5min.
（3）Then the lemon seed oil, burdock seed oil are added to step（2）Liquid in, continue stir 2min.
（4）Hyaluronic acid and potassium sorbate are eventually adding, is stirred, is cooled to normal temperature, it is filling after sterilizing.
Embodiment 2
A kind of antibacterial skin moistening liquid soap described in the present embodiment, each material quality percentage are：The lemon seed oil 12%, burdock seed oil
5%, Herba Lysimachiae extract 6%, Radix Pulsatillae extract 3%, sodium laureth sulfate 14%, Cocoamidopropyl betaine 8% is transparent
Matter acid 2%, potassium sorbate 0.2%, surplus are deionized water, and the mass percent sum of all raw materials is 100%.
A kind of preparation method of antibacterial skin moistening liquid soap described in the present embodiment comprises the following steps：
（1）Deionized water is heated to 95 DEG C, then adds sodium laureth sulfate, 5min is stirred, adds coconut oleoyl amine third
Base glycine betaine, continue stirring 9 minutes to uniform.
（2）Herba Lysimachiae extract, Radix Pulsatillae extract are added to step（1）Liquid in, continue stir 3min.
（3）Then the lemon seed oil, burdock seed oil are added to step（2）Liquid in, continue stir 3min.
（4）Hyaluronic acid and potassium sorbate are eventually adding, is stirred, is cooled to normal temperature, it is filling after sterilizing.
Embodiment 3
A kind of antibacterial skin moistening liquid soap described in the present embodiment, each material quality percentage are：One kind described in the present embodiment contains
The preparation method of the antibacterial skin moistening liquid soap of the lemon seed oil and burdock seed oil comprises the following steps：The lemon seed oil 8%, burdock seed oil
6%, Herba Lysimachiae extract 8%, Radix Pulsatillae extract 4%, sodium laureth sulfate 10%, Cocoamidopropyl betaine 10% is transparent
Matter acid 1%, potassium sorbate 0.3%, surplus are deionized water, and the mass percent sum of all raw materials is 100%.
A kind of preparation method of antibacterial skin moistening liquid soap described in the present embodiment comprises the following steps：
（1）Deionized water is heated to 90 DEG C, then adds sodium laureth sulfate, 7min is stirred, adds coconut oleoyl amine third
Base glycine betaine, continue stirring 8 minutes to uniform.
（2）Herba Lysimachiae extract, Radix Pulsatillae extract are added to step（1）Liquid in, continue stir 3min.
（3）Then the lemon seed oil, burdock seed oil are added to step（2）Liquid in, continue stir 2.5min.
（4）Hyaluronic acid and potassium sorbate are eventually adding, is stirred, is cooled to normal temperature, it is filling after sterilizing.
Embodiment 4
A kind of antibacterial skin moistening liquid soap described in the present embodiment, each material quality percentage are：The lemon seed oil 10%, burdock seed oil
5%, Herba Lysimachiae extract 7%, Radix Pulsatillae extract 3%, sodium laureth sulfate 12%, Cocoamidopropyl betaine 9% is transparent
Matter acid 2%, potassium sorbate 0.2%, surplus are deionized water, and the mass percent sum of all raw materials is 100%.
A kind of preparation method of antibacterial skin moistening liquid soap described in the present embodiment comprises the following steps：
（1）Deionized water is heated to 90 DEG C, then adds sodium laureth sulfate, 6min is stirred, adds coconut oleoyl amine third
Base glycine betaine, continue stirring 8 minutes to uniform.
（2）Herba Lysimachiae extract, Radix Pulsatillae extract are added to step（1）Liquid in, continue stir 4min.
（3）Then the lemon seed oil, burdock seed oil are added to step（2）Liquid in, continue stir 2.5min.
（4）Hyaluronic acid and potassium sorbate are eventually adding, is stirred, is cooled to normal temperature, it is filling after sterilizing.
Hand cleanser clean result is tested：
The volunteer for participating in this experiment totally 90 people, is randomly divided into 3 groups, each 15 people of every group of men and women, is coated on hand often in each volunteer
The dirt seen（Such as greasy dirt stain, dust etc.）, then the volunteer of 1 group of embodiment washed one's hands using the hand cleanser of embodiment 1, embodiment
2 groups of volunteer is washed one's hands using the hand cleanser of embodiment 2, and the volunteer that 3 groups of embodiment is washed one's hands using the hand cleanser of embodiment 3,
The volunteer that 4 groups of embodiment is washed one's hands using the hand cleanser of embodiment 4, is cleaned 3 times for each person every day, and this test period is 30 days,
Result of the test is shown in Table 1.
The hand cleanser clean result of table 1
Antibacterial skin moistening liquid soap dirt-removing power by the results showed that present invention of table 1 is good, and four groups of embodiment hand cleanser
In, the hand cleanser dirt-removing power of embodiment 4 is best, and the hand cleanser dirt-removing power of embodiment 3 is taken second place, embodiment 2 and embodiment 1
Hand cleanser dirt-removing power is slightly less than the hand cleanser of embodiment 4 and embodiment 3.
The fungistatic effect experiment of hand cleanser：
The volunteer for participating in this experiment totally 80 people, 4 groups are randomly divided into, each 10 people of every group of men and women is real after each volunteer's daily routines
The volunteer for applying 1 group of example is washed one's hands using the hand cleanser of embodiment 1, and the volunteer that 2 groups of embodiment is washed using the hand cleanser of embodiment 2
Hand, the volunteer that 3 groups of embodiment are washed one's hands using the hand cleanser of embodiment 3, and the volunteer that 4 groups of embodiment is washed using embodiment 4
Hand liquid is washed one's hands, and the volunteer of common commercially available hand cleanser group is washed one's hands using common commercially available hand cleanser, after hand drying, with sterile tweezer
Learn from else's experience aseptic cotton carrier that sterile saline infiltrated of sub-folder carries out microorganism and taken in the palm and the back of the hand of the right-hand man of volunteer
Sample, everyone wipes 2 times each sample position.Cotton swab after having sampled is put into the sterile chlorine for adding PH7.0 in sterile tool plug test tube
Change sodium-peptone buffer agent to 40ml, as test liquid.Take 1ml to be placed in a diameter of 90mm sterile petri dish, pour into 15-
The nutrient agar of 20ml temperature -45 DEG C of fusings at 40 DEG C, mixes, culture is inverted after culture medium solidifying, observe bacterium colony
Growing state, co-culture 3 days, cultivated in 30 DEG C -35 DEG C of insulating box, each group of data is averaged.Examination criteria：Micro- life
Thing limit（cfu≤120/40ml）.Result of the test is shown in Table 2.
The fungistatic effect of table 2 is tested
From the experimental result of table 2, a kind of fungistatic effect of antibacterial skin moistening liquid soap of the invention is good, and embodiment 4 is washed one's hands
The fungistatic effect of liquid is best, and the hand cleanser effect of embodiment 3, embodiment 2 and embodiment 1 is taken second place, but effect is superior to common city
Sell hand cleanser.
Hand cleanser soothing effect is tested：
Participating in the volunteer of this experiment has 50 people, is randomly divided into 5 groups, each 5 people of every group of men and women, the volunteer that 1 group of embodiment uses
The hand cleanser of embodiment 1 is washed one's hands, and the volunteer that 2 groups of embodiment is washed one's hands using the hand cleanser of embodiment 2, the aspiration that 3 groups of embodiment
Person is washed one's hands using the hand cleanser of embodiment 3, and the volunteer that 4 groups of embodiment is washed one's hands using the hand cleanser of embodiment 4, commonly commercially available to wash
The volunteer of hand liquid group is washed one's hands using common commercially available hand cleanser, the volunteer of blank group using clear water wash one's hands and without using hand cleanser
Wash one's hands.Each volunteer washes 3 times daily, and wash one's hands time 40s every time, and this test period is 30 days.Made by professional and technical personnel
Cutaneous roughness is determined with the Multi-functional skin mirror image analyzer systems of MicroSkin II, after each group volunteer uses hand cleanser
Skin mean roughness the results are shown in Table 3.
The cutaneous roughness rate of change of table 3
From the experimental result of table 3, a kind of soothing effect of antibacterial skin moistening liquid soap of the invention is good, can reduce hand skin
Degree of roughness.The hand cleanser soothing effect of embodiment 4 is best, the hand cleanser effect time of embodiment 3, embodiment 1 and embodiment 2
It, but effect is superior to common commercially available hand cleanser.
Claims (6)
- A kind of 1. antibacterial skin moistening liquid soap, it is characterised in that：The hand cleanser is made by following raw material, each raw material and its quality hundred Point ratio is：The lemon seed oil 8%-12%, burdock seed oil 4%-6%, Herba Lysimachiae extract 6%-8%, Radix Pulsatillae extract 2%-4%, bay Ether sulfate 10%-14%, Cocoamidopropyl betaine 8%-10%, hyaluronic acid 1%-3%, potassium sorbate 0.1%-0.3% are remaining Measure as deionized water.
- 2. antibacterial skin moistening liquid soap according to claim 1, it is characterised in that：Described the lemon seed oil is made by the following method ：It is 3-4mm that dry lemon seed is crushed into particle diameter, adds the 8-12 times of deionized water measured, the ultrasound in the case where frequency is 48-50KHz 28-32min is extracted, it is standby, with volatile oil is collected after extraction by steam distillation 3-4h, produce the lemon seed oil.
- 3. antibacterial skin moistening liquid soap according to claim 1, it is characterised in that：Described burdock seed oil is made by the following method ：It is 3-4mm that dry great burdock achene seed is crushed into particle diameter, adds the 10-12 times of deionized water measured, in the case where frequency is 44-48KHz Ultrasonic extraction 46-50min, it is standby, with volatile oil is collected after extraction by steam distillation 3.8-4.2h, produce burdock seed oil.
- 4. antibacterial skin moistening liquid soap according to claim 1, it is characterised in that：Described Herba Lysimachiae extract is pressed with lower section Method is made：Desmodium herb is taken, drying is cleaned, is shredded, the 13-15 times of 70%-80% measured ethanol is then added, in 58- Constant temperature refluxing extraction 2-3 times at 62 DEG C, each 1.5-2.5h, filtering, merging filtrate, with Rotary Evaporators in 38-42 DEG C of constant temperature It is lower that concentration filtrate is evaporated under reduced pressure, ethanol is reclaimed, thick liquid is obtained, thick liquid is dried in vacuo at 28-32 DEG C, produces gold Money grass extract.
- 5. antibacterial skin moistening liquid soap according to claim 1, it is characterised in that：Described Radix Pulsatillae extract is pressed with lower section Method is made：The root of the Chinese bulbul is taken, drying is cleaned, is shredded, the 11-13 times of 75%-85% measured ethanol is then added, 50 Constant temperature refluxing extraction 2-3 times, each 2.4-2.6h at DEG C -60 DEG C, filtering, merging filtrate, with Rotary Evaporators in 36-40 DEG C of perseverance Temperature is lower to be evaporated under reduced pressure concentration filtrate, reclaims ethanol, obtains thick liquid, thick liquid is dried in vacuo at 27-29 DEG C, produce Radix Pulsatillae extract.
- 6. the preparation method of the antibacterial skin moistening liquid soap described in claim 1 ~ 5 any one claim, it is characterised in that tool Body comprises the following steps：（1）Deionized water is heated to 85-95 DEG C, then adds sodium laureth sulfate, 5-7min is stirred, adds cocounut oil acyl Amine CAB, continue to stir 7-9 minutes to uniform；（2）Herba Lysimachiae extract, Radix Pulsatillae extract are added to step（1）Liquid in, continue stir 3-5min；（3）Then the lemon seed oil, burdock seed oil are added to step（2）Liquid in, continue stir 2-3min；（4）Hyaluronic acid and potassium sorbate are eventually adding, is stirred, is cooled to normal temperature, it is filling after sterilizing.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105287297A (en) * | 2015-11-24 | 2016-02-03 | 新会区会城美和商行 | Gotu kola Chinese herbal hand-washing solution and preparation method thereof |
| CN105434215A (en) * | 2015-11-24 | 2016-03-30 | 新会区会城美和商行 | Fructus cnidii Chinese herbal liquid soap and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105287297A (en) * | 2015-11-24 | 2016-02-03 | 新会区会城美和商行 | Gotu kola Chinese herbal hand-washing solution and preparation method thereof |
| CN105434215A (en) * | 2015-11-24 | 2016-03-30 | 新会区会城美和商行 | Fructus cnidii Chinese herbal liquid soap and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 高学敏: "《中药学》", 30 September 2002, 中国中医药出版社 * |
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