CN107690279A - 非人动物表现出上运动神经元功能和下运动神经元功能以及感知减弱 - Google Patents

非人动物表现出上运动神经元功能和下运动神经元功能以及感知减弱 Download PDF

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CN107690279A
CN107690279A CN201680016100.0A CN201680016100A CN107690279A CN 107690279 A CN107690279 A CN 107690279A CN 201680016100 A CN201680016100 A CN 201680016100A CN 107690279 A CN107690279 A CN 107690279A
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B·伊基兹
M·拉克鲁瓦-福拉丽什
S·D·克罗尔
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Abstract

本发明提供了一种用于疾病如肌萎缩性脊髓侧索硬化症(ALS)中运动神经元功能紊乱的动物模型，包括经基因修饰的非人动物，所述经基因修饰的非人动物包含经基因修饰的DR6等位基因并在出生时及出生后若干周或月内表现出正常表型。但是，随着所述非人动物变老，其患有表现为一种或多种ALS样症状的运动神经元功能紊乱，这在发病后可快速发展。还提供了鉴定可用于预防、延迟或治疗ALS的候选试剂的方法。

Description

非人动物表现出上运动神经元功能和下运动神经元功能以及 感知减弱
相关申请的交叉引用
本申请要求美国临时申请序列号62/133,909(2015年3月16日提交)以及62/250,229(2015年11月3日提交)的权益，每个申请均据此以引用方式并入本文中。
序列表
通过EFS-Web以电子方式将序列表的正式文本作为ASCII格式的序列表提交，该文件名称为2016-03-16-T0041WO01-SEQ-LIST_ST25.txt，创建日期为2016年3月16日，文件大小为约685千字节，并且该文件与本说明书同时提交。该ASCII格式文档中所含的序列表是本说明书的一部分，并且全文以引用的方式并入本文。
技术领域
本申请整体涉及随时间推移上运动神经元、下运动神经元和/或感知发育减弱的非人动物，所述动物可为神经退行性障碍(例如运动神经元疾病诸如肌萎缩性脊髓侧索硬化症(ALS))提供可用模型。
背景技术
肌萎缩性脊髓侧索硬化症(ALS)(也称为卢伽雷氏病)是一种由于破坏负责随意运动的脊髓、脑干和皮质中运动神经元造成的致命的神经退行性疾病。这种疾病临床上表现为进行性肌无力和肌萎缩，在疾病发作3-5年内引起麻痹和死亡。
在美国大约20,000人患有ALS，并且每年新增5,000例ALS患者。ALS在世界范围内十分常见，影响所有种族和民族群体。ALS的平均发病年龄在40岁和60岁之间，但年轻人和老年男女也可患有ALS。在90％-95％的ALS病例中，该疾病是明显随机发生的(称为偶发性ALS(sALS))。在这类SALS病例中，不存在家族病史和明确相关的风险因素。在5％-10％的ALS病例中，存在遗传性基因联系(称为家族性ALS(fALS))。
在与ALS相关的突变中，长期以来认为在铜-锌过氧化物歧化酶(SOD1)基因中的那些突变通过毒性功能获得而非SOD1酶的抗氧化功能受损来引发ALS疾病。带有与fALS相关突变的其它基因包括alsin(ALS2)、senataxin(ALS4)、囊泡相关膜蛋白(VAPB、ALS8)、血管生成素以及动力蛋白激活蛋白的p150亚基(DCTN1)。近来，在具有或不具有明显家族史的ALS患者中已经鉴定出Tardbp的TDP-43-编码区中的三十多种突变，这些突变对应于大约4％的fALS和小于1％的sALS。多数带有TDP-43突变的患者具有经典的ALS表型但无认知缺陷，这表明TDP-43在ALS发展中的重要作用。另外，C9ORF72基因的启动子中的GGGGCC六核苷酸扩展重复序列似乎为fALS和sALS以及ALS相关的额颞叶痴呆(ALS-FTD)的非常常见的起因。
已经建立了用于ALS疾病的若干小鼠模型，这些模型包括下列品系：具有SOD1、TDP43或FUS突变的啮齿动物、ALS2-敲除小鼠以及具有经基因工程改造的编码神经丝亚单位的基因的小鼠。在这些模型中，人突变体SOD1(mSOD1)转基因小鼠模型是目前最常用的一种，因为它与ALS患者共有若干种临床表型。mSOD1小鼠的第一症状为在大约90至100日龄时出现的一个或多个肢体的轻微“抖动/震颤”。在后期阶段，小鼠开始表现出临床症状，首先表现出肌无力和/或后肢麻痹，然后轻瘫上升至前肢，最后出现严重四肢麻痹。然而，现有动物模型均不适用于人类疾病，因为动物并不表现上运动神经元症状、TDP43和/或SOD1聚集和/或非运动神经元损失。因此，需要更接近地反映人类ALS的动物模型。
发明内容
本文提供了一种经基因修饰的非人动物，其患有症状为上运动神经元、下运动神经元和/或感知功能紊乱的病症，因此可用作影响运动神经元的一种或多种神经退行性疾病(诸如肌萎缩性脊髓侧索硬化症(ALS)、原发性脊髓侧索硬化症、原发性脊髓侧索硬化症、进行性肌营养障碍等)的模型。具体地讲，本文提供了一种包含经修饰的内源性DR6基因座的啮齿动物(例如大鼠或小鼠)，其中经修饰的DR6基因座缺少(例如，不包含、不存在等)编码整个DR6胞质死亡结构域或DR6胞质结构域的第一核苷酸(例如，第一DNA、第一cDNA、第一基因组DNA等)序列，例如经修饰的DR6基因座缺少编码DR6胞质死亡结构域或DR6胞质结构域的任何部分的核苷酸序列。经修饰的DR6基因座还可缺少(i)编码整个DR6跨膜结构域的第二核苷酸(例如，第二cDNA、第二DNA、第二基因组DNA)序列，例如编码DR6跨膜结构域的任何部分的第二核苷酸序列；(ii)编码DR6胞外结构域或其任何部分的第三核苷酸(例如，第三cDNA、第三DNA、第三基因组DNA)序列，例如编码DR6胞外结构域的任何部分的第三核苷酸序列；(iii)第四核苷酸序列，例如从内源性啮齿动物DR6基因的整个外显子3横跨至整个外显子6(包括居间内含子)的第四基因组序列；和/或(iv)第五核苷酸序列，例如从内源性啮齿动物DR6基因的外显子2的一部分(例如碱基4103)横跨至整个外显子6例如终止密码子(包括居间内含子)的第四基因组序列，其中第五核苷酸序列编码全长和成熟内源性啮齿动物DR6蛋白。在一些实施方案中，啮齿动物为小鼠，并且经修饰的DR6等位基因缺少编码DR6胞质死亡结构域的第一核苷酸序列，例如经修饰的DR6等位基因缺少编码SEQ ID NO:15的第388-454位氨基酸或其任何部分的第一核苷酸序列。在一些实施方案中，提供了一种包含经修饰的DR6等位基因的小鼠，所述等位基因缺少编码胞质结构域(例如具有如SEQ ID NO:15的第330-614位氨基酸所示的氨基酸序列的胞质结构域)的核苷酸序列。在一些实施方案中，本文提供的小鼠包含经修饰的DR6等位基因，所述等位基因缺少编码成熟DR6蛋白的核苷酸序列，例如，如SEQ ID NO:15的第1-614位氨基酸所示。在一些实施方案中，经修饰的DR6等位基因缺少大于5kb的内源性基因组序列。在一些实施方案中，经修饰的DR6等位基因缺少大于10kb的内源性基因组序列。在一些实施方案中，经修饰的DR6等位基因缺少大于20kb的内源性基因组序列。在一些实施方案中，经修饰的DR6等位基因缺少大于30kb的内源性基因组序列。在一些实施方案中，经修饰的DR6等位基因缺少大于40kb的内源性基因组序列。在一些实施方案中，经修饰的DR6等位基因缺少大于50kb的内源性基因组序列。在一些实施方案中，啮齿动物对经修饰的DR6基因座为杂合或纯合的，所述基因座缺少编码内源性DR6胞外结构域、内源性跨膜结构域和/或内源性DR6胞质结构域的任何部分的核苷酸序列。
如本文提供的经基因修饰的啮齿动物可例如在内源性DR6基因座(例如，如本文所述的经修饰的内源性DR6基因座)处表达核酸，例如该核酸可随机插入啮齿动物的基因组或可操作地连接至内源性DR6转录调控序列，其中该核酸编码包含功能性DR6信号肽(例如，功能性异源DR6信号肽、功能性内源性DR6信号肽、功能性大鼠DR6信号肽、功能性小鼠DR6信号肽等)、跨膜结构域(例如，DR6跨膜结构域或异源跨膜结构域(例如，ROR1跨膜结构域))、报告基因蛋白(例如，β-半乳糖苷酶蛋白)或其组合的多肽，并且其中多肽缺少(例如，未可操作地融合至、不包含等)功能性DR6胞质结构域或其任何部分。在一些实施方案中，多肽也缺少功能性DR6胞外结构域或其任何部分。在一些实施方案中，多肽基本上由功能性DR6信号肽组成或由其组成。在一些实施方案中，多肽基本上由可操作地融合至跨膜结构域的功能性DR6信号肽组成或由其组成。在一些实施方案中，多肽基本上由可操作地融合至跨膜结构域的功能性DR6信号肽组成或由其组成，该跨膜结构域可操作地融合至报告基因蛋白。在一些实施方案中，多肽基本上由可操作地融合至跨膜结构域的功能性DR6信号肽组成或由其组成。在一些实施方案中，多肽基本上由跨膜结构域组成或由其组成。在一些实施方案中，多肽基本上由可操作地融合至报告基因蛋白的跨膜结构域组成或由其组成。在一些实施方案中，多肽基本上由报告基因蛋白组成或由其组成。在一些实施方案中，DR6信号肽为啮齿动物DR6信号肽(例如小鼠DR6信号肽)，例如，如SEQ ID NO:15的第1至41位氨基酸(或其任何部分)所示，例如由如SEQ ID NO:6所示的序列或其编码相同氨基酸序列但只是由于遗传密码的简并性而不同于SEQ ID NO:6的简并变体编码。在一些实施方案中，如本文提供的啮齿动物包含并表达核酸，该核酸包含、基本上由如SEQ ID NO:6所示的序列或其编码相同氨基酸序列但只是由于遗传密码的简并性而不同于SEQ ID NO:6的简并变体组成或由其组成。在一些实施方案中，跨膜结构域为ROR1跨膜结构域，例如由如SEQ ID NO:7所示的序列或其编码相同氨基酸序列但只是由于遗传密码的简并性而不同于SEQ ID NO:7的简并变体编码。在一些实施方案中，核酸序列包含、基本上由如SEQ ID NO:7所示的序列或其编码相同氨基酸序列但只是由于遗传密码的简并性而不同于SEQ ID NO:7的简并变体组成或由其组成。在一些实施方案中，报告基因蛋白为β-半乳糖苷酶，例如由如SEQ ID NO:8所示的序列或其编码相同氨基酸序列但只是由于遗传密码的简并性而不同于SEQ ID NO:8的简并变体编码。在一些实施方案中，核酸序列包含、基本上由SEQ ID NO:8或其编码相同氨基酸序列但只是由于遗传密码的简并性而不同于SEQ ID NO:8的简并变体组成或由其组成。在一些实施方案中，如本文提供的啮齿动物包含并表达编码可操作地融合至ROR1跨膜结构域的DR6信号肽的核酸，该ROR1跨膜结构域可操作地融合至β-半乳糖苷酶，例如，如本文提供的啮齿动物包含并表达如SEQ ID NO:17所示的核酸序列或其编码相同氨基酸序列但只是由于遗传密码的简并性而不同于SEQ ID NO:17的简并变体。
在一些实施方案中，核酸在内源性DR6基因座处，任选地可操作地连接至一个或多个内源性DR6调控元件(例如内源性转录调控元件)，使得啮齿动物对经修饰的DR6基因座为杂合或纯合的，所述基因座包含核酸但至少缺少编码整个内源性DR6胞质结构域或其整个任何部分(例如，整个DR6胞质死亡结构域)的核苷酸序列，并任选地还缺少编码整个内源性DR6跨膜结构域或其任何部分的另外的核苷酸序列和/或整个内源性DR6胞外结构域。
在一些实施方案中，内源性DR6基因座的修饰和/或如本文所述核酸的表达影响神经元、神经胶质细胞或其组合的功能。在一些实施方案中，核酸的表达致使例如上运动神经元和/或下运动神经元的功能减弱如功能紊乱，其可表现为例如(a)驼背；(b)异常后肢抱握；(c)运动协调和运动学习能力缺陷；(d)体重减轻以及(e)相比于与经基因修饰的啮齿动物具有相同遗传背景例如品系相同的对照啮齿动物感知减弱。在一些实施方案中，包含经修饰的DR6基因座和/或表达如本文所述的核酸的啮齿动物可表现出一种或多种运动神经元功能紊乱症状，例如上运动神经元和/或下运动神经元功能紊乱。在一些实施方案中，症状为(a)驼背；(b)异常后肢抱握；(c)运动协调和运动学习能力缺陷；(d)体重减轻和/或(e)例如相比于与经基因修饰的啮齿动物具有相同遗传背景例如品系相同的对照啮齿动物感知减弱。在一些实施方案中，一种或多种症状为选自震颤、痉挛性麻痹(僵直)、反射异常以及它们的组合的涉及上运动神经元功能紊乱的ALS样症状和/或选自肌无力和消瘦、肌束震颤以及它们的组合的涉及下运动神经元功能紊乱的ALS样症状。这类ALS样症状可使用盲法主观ALS-TDI神经系统评分、转杆测试、猫步测试、旷场测试中的一者或多者进行直观观察。另外，如本文所公开的啮齿动物与在介于8周龄和20周龄之间的对照野生型动物相比可表现出体重增加减缓。如本文所公开的啮齿动物也可表现出对疼痛刺激作出反应的延迟时间不足，而无论啮齿动物是否表现出运动神经元功能减弱，该运动神经元功能减弱表现为在转杆上时间不足、运动功能受损、猫步能力减弱以及它们的组合。
在一个方面，啮齿动物在出生时可能看起来非常正常(例如，肉眼看起来正常，例如运动神经元功能紊乱和/或感知减弱在盲法主观神经系统评分测定、转杆测试、猫步测试、旷场测试、体重测量和/或经受疼痛测试中并不明显)，但随其变老，便会患上一种或多种可见ALS样症状，例如啮齿动物在2周龄、3周龄、4周龄、5周龄、6周龄等之后可能患上一种或多种ALS样症状。在一个方面，如本文所述的啮齿动物小于4周龄并且不表现出任何ALS样症状。在一个方面，如本文所述的啮齿动物小于8周龄并且不表现出任何ALS样症状。在另一方面，啮齿动物在22周龄之前患上ALS样症状。在一个实施方案中，啮齿动物为至少16周龄或更大并表现出下列表型中的一者或多者：(a)驼背；(b)异常后肢抱握；(c)运动协调和运动学习能力缺陷；(d)体重减轻以及(e)与对照啮齿动物相比对疼痛刺激作出反应的时间延迟。
本文所公开的啮齿动物的基因表达模式，例如神经系统器官(脑、脊髓等)的基因标签可分别类似于(1)ALS患者的基因表达模式或患者器官(脑、脊髓等)的基因标签，和/或(2)另一ALS动物模型(例如SOD1非人动物)的基因表达模式或非人动物器官(脑、脊髓等)的基因标签。例如，本文所公开的啮齿动物的大脑和/或脊髓的基因表达模式可与人类ALS生物表达数据集(bioset)和/或鼠科动物SOD1生物表达数据集相关，这些生物表达数据集可与免疫应答有关。与人类ALS和/或鼠科动物SOD1生物表达数据集的这种相关性表明，在本文所公开的啮齿动物中观察到的病变与在患有ALS的人或SOD1动物模型中观察到的病变非常相似。在一些实施方案中，如本文所公开的啮齿动物可具有免疫应答相关基因标签，但与野生型啮齿动物相比，在外周神经系统上可能不表现出异常免疫应答。
在一个方面，如本文所公开的啮齿动物中运动神经元的数目近似于(例如不明显大于或小于)野生型啮齿动物中运动神经元的数目。在一些实施方案中，如本文所公开的啮齿动物的运动神经元相比于野生型啮齿动物的运动神经元表现出氧化应激反应增加。
在一个方面，如本文所述的啮齿动物为大鼠或小鼠。在一些实施方案中，啮齿动物为小鼠，来自选自129品系、C57BL/6品系以及混合C57BL/6×129品系的品系。
本文还提供了一种从本文所述啮齿动物分离的或来源于本文所述啮齿动物的组织或细胞(例如胚胎干细胞、运动神经元细胞等)，例如，可用组织学方法检查和/或培养的这些组织或细胞。还提供了本文所述的核酸。
还提供了方法，该方法包括培养从本文所述的啮齿动物分离的细胞或细胞群，这可得到(例如)可用于体外操作的运动神经元。在一些实施方案中，提供了产生相比于对照运动神经元细胞表现出氧化应激反应增加的运动神经元群的方法，这种方法包括形成来源于本文所提供啮齿动物的胚体并将胚体分化成运动神经元。在一些实施方案中，胚体是由内细胞团胚胎干细胞发育而来的。在一些实施方案中，分离内细胞团胚胎干细胞，并例如在胚胎干细胞培养基(ESM：DMEM+15％胎牛血清+青霉素/链霉素+谷氨酰胺+非必需氨基酸+核苷+β-巯基乙醇+丙酮酸钠+LIF)中培养2天以形成胚体。随后胚体可在分化培养基(高级DMEM/F12+Neurobasal培养基+10％敲除血清+青霉素/链霉素+谷氨酰胺+β-巯基乙醇)中培养例如1-3天(例如2天)，然后在视黄酸和平和受体激动剂中进一步培养例如5天。由从本文所提供的啮齿动物分离的内细胞团胚胎干细胞发育而来的分化运动神经元可例如在胚胎干细胞衍生的运动神经元培养基(ESMN：Neurobasal培养基+2％马血清+B27+谷氨酰胺+青霉素/链霉素+β-巯基乙醇+10ng/mL GDNF、BDNF、CNTF)中成熟，以形成稳定的运动神经元细胞系，其相比于由不包含经修饰的DR6等位基因和/或核酸的啮齿动物发育而来的运动神经元细胞表现出氧化应激反应增加。
本文还提供了一种用于调节运动神经元功能紊乱的候选试剂的鉴定方法，该候选试剂可用于治疗、预防和/或抑制ALS，这种方法包括(a)向本文所公开的啮齿动物施用试剂；以及(b)确定相比于具有相同基因组结构但不接受候选试剂的测试对照啮齿动物，所述啮齿动物中候选试剂的效应，例如确定相比于对照啮齿动物，候选试剂是否预防、抑制、延迟和/或逆转所述啮齿动物的至少一种ALS样症状；其中至少一种ALS样症状例如啮齿动物运动神经元功能紊乱症状诸如驼背、异常后肢抱握、运动协调缺陷、运动学习能力缺陷、体重减轻以及感知缺陷的预防、抑制、延迟和/或逆转表明候选试剂可用于治疗运动神经元功能紊乱，例如预防和/或抑制ALS。试剂可在啮齿动物ALS样症状发作之前、与该症状发作同时或在该症状发作之后施用，例如在通过盲法主观ALS-TDI神经系统评分、转杆测试、猫步测试、旷场测试、体重测量或确定对疼痛刺激作出反应的延迟时间例如在两个或更多个不同时间点检测运动神经元功能紊乱的至少一种症状之前、与进行该检测同时或在进行该检测之后施用。
在一些实施方案中，候选试剂调节运动神经元功能紊乱的至少一种症状，使其减轻至少10％，例如至少15％，例如至少20％。在其它实施方案中，候选试剂的存在调节症状，使运动神经元功能紊乱的至少一种症状例如减轻至少50％，例如减轻至少75％，例如减轻至少80％，例如减轻至少95％，例如减轻至少99％。在一些实施方案中，候选试剂预防运动神经元功能紊乱的至少一种症状。通过(1)预防和/或抑制驼背和异常后肢抱握中的至少一者和/或通过(2)预防和/或修复运动协调缺陷、运动学习能力缺陷、体重减轻和/或感知缺陷来调节所述至少一种症状的候选试剂可用于治疗神经退行性疾病例如ALS。
确定相比于对照啮齿动物，试剂是否预防、抑制、延迟和/或逆转所述啮齿动物的至少一种ALS样症状的方法可包括检查从啮齿动物分离的组织和/或细胞，例如通过组织化学分析该组织和/或细胞以了解该组织和/或细胞的显微解剖学、功能和结构；细胞、组织和/或器官培养、显微镜技术和/或评估蛋白(例如髓磷脂结合蛋白(MBP)、神经生长因子受体(NGFR)、胆碱乙酰转移酶(Chat)、Mnx同源异型框、谷氨酸[NMDA]受体亚单位3B(Grin3b)以及谷氨酸受体2(Gria2))的表达。在一个方面，所评估细胞为神经元、神经胶质细胞或其组合。在另一方面，所评估组织为大脑和/或脊髓。确定相比于对照啮齿动物，试剂是否预防、抑制、延迟和/或逆转啮齿动物的至少一种ALS样症状的方法还可包括主观ALS-TDI神经系统评分、转杆测试、猫步测试、旷场测试和体重测量和/或确定对疼痛刺激作出反应的延迟时间。
在一些实施方案中，测试到的至少一种症状表明上运动神经元功能紊乱，例如所述至少一种症状选自震颤、痉挛性麻痹(僵直)、反射异常以及它们的组合。在一些实施方案中，测试到的至少一种症状表明下运动神经元功能紊乱，例如所述至少一种症状选自肌无力和消瘦、肌束震颤以及它们的组合。在一些实施方案中，所评估的至少一种症状为体重增加减缓。在一些实施方案中，所测试到的至少一种功能为伤害感受减弱。
本文还提供了一种鉴定用于减少运动神经元的氧化应激反应的候选试剂的方法，包括：(a)在存在或不存在试剂的情况下培养来源于如本文所公开的非人动物模型的运动神经元；(b)确定相比于在不存在试剂的情况下培养的对照运动神经元，试剂是否预防、抑制和/或减少运动神经元的氧化应激反应；其中运动神经元的氧化应激反应的预防、抑制和/或减少表明，用于减少运动神经元的氧化应激反应的候选试剂例如并且可为用于治疗、预防和/或抑制ALS的候选试剂。
在一些实施方案中，候选试剂将运动神经元的氧化应激反应减少至少10％，例如至少15％，例如至少20％。在其它实施方案中，候选试剂的存在抑制运动神经元的氧化应激反应，例如使其减少至少50％，例如减少至少75％，例如减少至少80％，例如减少至少95％，例如减少至少99％。在一些实施方案中，候选试剂预防运动神经元的氧化应激反应，例如氧化应激反应水平类似于野生型运动神经元的氧化应激反应水平。
本文还提供了一种包含(a)5’靶向臂和3’靶向臂、(b)选择盒以及任选地(c)跨膜结构域编码序列的靶向载体，其中5’靶向臂和3’靶向臂引导载体插入内源性DR6信号肽序列下游的内源性DR6基因座中。在一个实施方案中，跨膜结构域编码序列编码ROR1跨膜结构域。在另一个实施方案中，跨膜结构域编码序列可操作地连接至报告基因。在一个实施方案中，选择盒包含报告基因、药物抗性基因或其组合。在另一个实施方案中，选择盒包含药物抗性基因。在一些实施方案中，选择盒包含新霉素磷酸转移酶基因。在一些实施方案中，如本文提供的靶向载体包含如SEQ ID NO:16所示的序列。在一些实施方案中，靶向载体不包含选择盒。在一些实施方案中，如本文提供的靶向载体包含如SEQ ID NO:5所示的序列。
本文还提供了包含如本文所述的靶向载体的啮齿动物细胞，诸如胚胎干细胞，例如鼠科动物胚胎干细胞，例如C57BL/6NTac胚胎干细胞。
附图说明
图1示出了用于靶向破坏DR6基因座的策略。野生型小鼠DR6基因座如顶部线所示(未按比例绘制)，从5'至3'示出了5'UTR(白框)、起始密码子(ATG)、外显子1-6(虚线框)、终止密码子(TAG)和3'UTR。如图所示，内源性小鼠信号序列由外显子1以及外显子2的一部分(从起始密码子起约4103个碱基)编码，并且编码信号肽的核酸序列在与Zen-Ub1盒重组之后留下，如底部线所示(未按比例绘制)。如图1所示，ZEN-Ub1靶向载体(SEQ ID NO:5)(从5'至3')包含5'同源臂(5'臂；SEQ ID NO:1)、可操作地连接至大肠杆菌(E.coli)LacZ报告基因(LacZ；SEQ ID NO:8)的ROR1跨膜结构域编码序列(TM；SEQ ID NO:7)，该报告基因可操作地连接至多聚腺苷酸化信号(pA；SEQ ID NO:9)。Zen-Ub1盒也包括选择盒，该选择盒包含来自可操作地连接至新霉素磷酸转移酶抗性基因(Neo；SEQ ID NO:12)的人类泛素C基因(hUB；SEQ ID NO:11)的启动子，该新霉素磷酸转移酶抗性基因可操作地连接至多聚腺苷酸信号(pA；SEQ ID NO:13)，该选择盒侧接相同的loxP核酸序列(SEQ ID NO:10)。Zen-UB1盒的3'同源臂(3'臂)如SEQ ID NO:14所示。在同源重组之后，所得等位基因包含编码可操作地连接至ROR1跨膜结构域编码序列和LacZ报告基因的内源性DR6信号序列的核酸序列(该核酸序列如SEQ ID NO:17所示)，并缺少从外显子2的碱基4103开始至外显子6的终止密码子的整个内源性基因组序列，例如缺少编码内源性胞质结构域、跨膜结构域和胞外结构域的核苷酸序列。
图2A至图2I示出了与性别无关的随时间推移快速发展的DR6-/-小鼠肌萎缩性脊髓侧索硬化症(ALS)样运动损伤。图2A示出了野生型小鼠和DR6-/-小鼠在不同时间点(x轴)的平均运动损伤得分(y轴)，而图2B示出了雄性和雌性DR6-/-小鼠在不同时间点(x轴)的平均运动损伤得分。图2C示出了野生型小鼠和DR6-/-小鼠在不同时间点(x轴)的平均僵直得分(y轴)，而图2D示出了雄性小鼠和雌性DR6-/-小鼠在不同时间点(x轴)的平均僵直得分。图2E示出了野生型小鼠和DR6-/-小鼠在不同时间点(x轴)的平均震颤得分(y轴)，而图2F示出了雄性和雌性DR6-/-小鼠在不同时间点(x轴)的平均震颤得分。图2G示出了在介于9周龄至21周龄(x轴)之间的野生型小鼠和DR6-/-小鼠的平均运动损伤得分(y轴)。图2H示出了在介于9周龄至21周龄(x轴)之间的野生型小鼠和DR6-/-小鼠的平均僵直得分(y轴)。图2I示出了在介于9周至21周(x轴)之间的野生型小鼠和DR6-/-小鼠的平均震颤得分。对于实验1(图2A至图2F)，野生型小鼠n＝12，并且DR6-/-小鼠n＝16(雄性DR6-/-小鼠n＝8；雌性DR6-/-小鼠n＝8)，并且在每个时间点，对于每个测试野生型动物得分为0。对于实验2(图2G至图2I)，野生型小鼠n＝14，并且DR6-/-小鼠n＝18。所有数据均报告为平均值±SEM。进行双因素ANOVA统计分析，比较野生型小鼠的值与敲除小鼠的值，其中*表示P≤0.05，**表示P≤0.01，***表示P≤0.001，并且****表示P≤0.0001。
图3A至图3F示出了DR6-/-小鼠的ALS样表型，表现为体重减轻和显著运动异常。图3A：左图和右图示出了野生型小鼠(tnsfr21+/+)和DR6-/-小鼠(tnsfr21-/-)分别在2014年5月29日和2014年6月11日的体重(y轴；克)。图3B：左图和右图分别示出了野生型小鼠(tnsfr21+/+；条纹柱)和DR6-/-小鼠(tnsfr21-/-；实心柱)从转杆上掉落的最大和中值延迟时间(y轴；秒)。图3C：示出了野生型小鼠(tnsfr21+/+；条纹柱)和DR6-/-小鼠(tnsfr21-/-；实心柱)在60分钟内的总不动性(y轴)、基本运动(y轴)和精细运动动作。图3D：示出了野生型小鼠(tnsfr21+/+；条纹柱)和DR6-/-小鼠(tnsfr21-/-；实心柱)在一小时内的X+Y步行量(y轴)。图3E：左图和右图分别示出了野生型小鼠(tnsfr21+/+；条纹柱)和DR6-/-小鼠(tnsfr21-/-；实心柱)的总直立活动(y轴)和总直立时间(y轴；秒)。图3F：左图和右图分别示出了野生型小鼠(tnsfr21+/+；条纹柱)和DR6-/-小鼠(tnsfr21-/-；实心柱)行进的总距离和总休息时间(y轴；总共60分钟)。*(p<0.05)表示这两组小鼠之间统计意义上的显著性差异。
图4A至图4C示出了9周龄至21周龄的野生型小鼠(n＝14)和DR6-/-小鼠(n＝18)(x轴)的(A)平均体重(y轴；以克计体重)、(B)从转杆上掉落的中值延迟时间(y轴；秒)和(C)从转杆上掉落的最大时间(y轴；秒)。花费在转杆上的最大时间为180秒。所有数据均报告为平均值±SEM。进行双因素ANOVA统计分析，比较野生型小鼠的值与敲除小鼠的值，其中*表示P≤0.05，**表示P≤0.01，***表示P≤0.001，并且****表示P≤0.0001。
图5A至图5H示出了野生型小鼠和DR6-/-小鼠的旷场运动行为，例如介于10周龄-21周龄之间的野生型动物(n＝14)和DR6-/-动物(敲除；n＝16)在一小时内的总距离(图5A)、不动性(图5B)、总直立时间(图5C)、基本运动(图5D)、精细运动(图5E)、X+Y步行量(图5F)、总休息时间(图5G)和直立活动(图5H)。所有数据均报告为平均值±SEM。进行双因素ANOVA统计分析，比较野生型小鼠的值与敲除小鼠的值，其中*表示P≤0.05，**表示P≤0.01，***表示P≤0.001，并且****表示P≤0.0001。
图6A至图6F示出了猫步行为，例如介于10周龄-21周龄之间的野生型动物(n＝14)和DR6-/-动物(敲除；)的肢体间协调(图6A)、爪压力(图6B)、爪印面积(图6C)、步长(图6D)、站立期(图6E)、摆动期(图6F)、摆动速度(图6G)和占空比(图6H)。所有数据均报告为平均值±SEM。进行双因素ANOVA统计分析，比较野生型小鼠的值与敲除小鼠的值，其中*表示P≤0.05，**表示P≤0.01，***表示P≤0.001，并且****表示P≤0.0001。
图7A至图7G示出了介于9周龄和21周龄(x轴)之间的野生型动物(●，n＝14)和DR6-/-动物(■；n＝18)的前腿和后腿的步态能力。图7A提供了平均前爪压力和后爪压力。图7B提供了平均前爪印面积和后爪印面积。图7C提供了平均前步长和后步长。图7D提供了平均前站立期和后站立期。图7E提供了平均前摆动速度和后摆动速度。图7F提供了平均前摆动期和后摆动期。图7G提供了平均前占空比和后占空比。所有数据均报告为平均值±SEM。进行双因素ANOVA统计分析，比较野生型小鼠的值与敲除小鼠的值，其中*表示P≤0.05，**表示P≤0.01，***表示P≤0.001，并且****表示P≤0.0001。
图8示出了介于10-21周龄之间的野生型动物和DR6-/-动物(敲除；)动物的神经系统评分，例如运动损伤得分、震颤得分和僵直得分。所有数据均报告为平均值±SEM。进行双因素ANOVA统计分析，比较野生型小鼠的值与敲除小鼠的值，其中*表示P≤0.05，**表示P≤0.01，***表示P≤0.001，并且****表示P≤0.0001。
图9上图示出了从野生型动物(左侧)或DR6-/-动物(右侧)分离并用苏木精和伊红免疫染色的大脑的代表性载玻片。在下图中还示出了野生型动物(左侧柱状图)或DR6-/-动物(敲除；右侧柱状图)的脊髓(y轴；运动神经元的平均数目)中运动神经元的数目。
图10示出了野生型动物(左侧柱状图)或DR6-/-动物(敲除；右侧柱状图)的脊髓(左图)和大脑(右图)中MBP(上图)或NGFR(下图)的mRNA水平(相对于β-肌动蛋白的平均mRNA水平；y轴)。
图11示出了野生型动物(左侧柱状图)或DR6-/-动物(敲除；右侧柱状图)的脊髓(左图)和大脑(右图)中Chat(上图)或Mnx(下图)的mRNA水平(相对于β-肌动蛋白的平均mRNA水平；y轴)。
图12示出了野生型动物(左侧柱状图)或DR6-/-动物(敲除；右侧柱状图)的脊髓(左图)和大脑(右图)中Grin3b(上图)或Gria2(下图)的mRNA水平(相对于β-肌动蛋白的平均mRNA水平；y轴)。
图13示出了从野生型小鼠(WT；x轴)或DR6-/-(KO；x轴)小鼠的胸腺、脾或外周得到的不同细胞的数目占亲本细胞的百分比(亲本％；y轴)。
图14示出了从野生型小鼠(WT；x轴)或DR6-/-(KO；x轴)小鼠的胸腺、脾或外周得到的不同细胞的数目占亲本细胞的百分比(亲本％；y轴)。
图15示出了野生型动物(n＝6；黑色柱状图)或DR6-/-动物(n＝6；灰色柱状图)的血清中不同细胞因子或趋化因子(x轴)的浓度(平均观测浓度；y轴)。
图16A示出了在培养获自野生型动物(DR6+/+；黑色柱状图；x轴)和DR6+/-动物(DR6+/-；网纹柱状图；x轴)的胚胎干细胞起源的运动神经元之后得到的活细胞的数目(y轴)。图16B示出了在第1天或第7天(x轴)时获自野生型动物(DR6+/+；黑色柱状图)和杂合动物(DR6+/-；网纹柱状图)的胚胎干细胞起源的运动神经元在胚胎干细胞起源的运动神经元(ESMN)培养基中的氧化应激(平均光密度；y轴)。****表示P≤0.0001。
图17A示出了在介于10-21周龄之间的野生型动物(n＝27)、杂合DR6+/-(n＝14)动物和纯合DR6-/-(n＝33)动物的神经系统评分，例如运动损伤得分、震颤得分和僵直得分。图17B示出了在介于10-21周龄之间的野生型动物(n＝27)、杂合DR6+/-动物(n＝14)和纯合DR6-/-动物(n＝33)的平均体重(y轴；以克计体重)。图17C的上图示出了在12周龄至21周龄时野生型(n＝13)动物、杂合DR6+/-动物(n＝14)和纯合DR6-/-动物(n＝15)从转杆上掉落的中值延迟时间(y轴；秒)；下图示出了在12周龄至21周龄时野生型动物(n＝13)、杂合DR6+/-动物(n＝14)和纯合DR6-/-动物(n＝15)从转杆上掉落的最大时间(y轴；秒)。花费在转杆上的最大时间为180秒。图17D-17K示出了野生型小鼠、杂合DR6+/-小鼠和纯合DR6-/-小鼠的旷场运动行为，例如在介于10-21周龄之间的野生型动物(n＝27)、杂合DR6+/-动物(n＝14)和纯合DR6-/-动物(n＝33)在一小时内的直立活动(图 17D)、总直立时间(图 17E)、基本运动(图17F)、不动性(图 17G)、精细运动(图 17H)、X+Y步行量(图17I)、总距离(图17J)和总休息时间(图17K)。图17L-17Z示出了猫步行为，例如在介于10-21周龄之间的野生型动物(n＝27)、杂合DR6+/-动物(n＝14)和纯合DR6-/-动物(n＝33)的步长(图 17L和17M)、摆动速度(图17N和17O)、肢体间协调(图17P)、摆动期(图17Q和17R)、占空比(图17S和17T)、爪印面积(图17U和17V)、站立期(图17W和17X)以及爪压力(图17Y和17Z)。所有数据均报告为平均值±SEM。进行双因素ANOVA统计分析，比较野生型小鼠的值与敲除小鼠的值，其中*表示P≤0.05，**表示P≤0.01，***表示P≤0.001，并且****表示P≤0.0001。
图18示出了经受温热至48℃、52℃或55℃恒定温度的金属板处理的野生型动物(左侧柱状图；n＝13)、杂合DR6+/-动物(中间柱状图；n＝14)和纯合DR6-/-动物(右侧柱状图；n＝15)对伤害感受性反应的延迟时间(时间；y轴)。所有数据均报告为平均值±SEM。进行双因素ANOVA统计分析，比较野生型小鼠的值与敲除小鼠的值，其中*表示P≤0.05，**表示P≤0.01，***表示P≤0.001，并且****表示P≤0.0001。
具体实施方式
肌萎缩性脊髓侧索硬化症(“ALS”)(也称为卢伽雷氏病)是一种影响多达20,000名美国人的致命进行性神经系统疾病，在美国每年新增5,000个病例。这种障碍属于称为运动神经元疾病的障碍类别。当控制随意运动的大脑和脊髓中特定神经细胞逐渐退化时，出现ALS。此时，大脑和脊髓都丧失向机体的肌肉发起和发送消息的能力。而不能发挥作用的肌肉逐渐萎缩并抽搐。
根据哪种肌肉首先衰弱，ALS自身以不同方式表现。症状可包括摔跟头，丧失手和臂的运动控制，说话、吞咽和/或呼吸困难，持续疲劳以及抽搐和痉挛，有时非常严重。最后，当隔膜和胸壁的肌肉变得太弱时，患者需要呼吸机进行呼吸。患有ALS的多数患者通常在确诊3至5年之后死于呼吸衰竭；但是，一些患者可在确诊之后生存10年或更长。ALS在中年发病。男性更可能患上这种疾病，患病概率是女性的约1.5倍。
ALS不能治愈，也不存在预防或逆转这种障碍病程的有效疗法。食品和药物管理局(FDA)最近批准了利鲁唑，该药物经证实是可延长ALS患者生存期的第一药物。患者也可接受针对其某些症状的支持治疗。
本文提供了一种用于ALS的动物模型，其可用于找出可用于治疗人类ALS的候选试剂。
本文所述或所参考的技术和规程通常便于理解，并通常由本领域技术人员采用常规方法诸如例如，在Sambrook et al.,Molecular Cloning:A Laboratory Manual2nd.edition(1989)Cold Spring Harbor Laboratory Press,Cold Spring Harbor,N.Y.(Sambrook等人，《分子克隆：实验手册第二版》，1989年，冷泉港实验室出版社，纽约州冷泉港)中所述的广泛利用的分子克隆方法。除非另外指明，否则根据需要，通常根据制造商限定的协议和/或参数实施涉及使用可商购获得的试剂盒和试剂的规程。
在描述本方法和测定法之前，应当理解，本发明不限于所述特定方法、协议、细胞系、动物物种或属、构建体和试剂，因此这些当然可改变。必须指出的是，单数形式“一”和“所述”包括多个指代物，除非上下文另有明确表示。因此，例如，提及“基因改变”包括多种这类改变，并且提及“探针”包括提及一个或多个探针以及本领域技术人员已知的其等同物，等等。说明书和相关权利要求书中引用的所有数字(例如，氨基酸22-81、1-354等)应当理解为由术语“约”修饰。
本文提到的所有出版物均以引用方式并入本文，以公开和描述与所引用出版物有关的方法和/或材料。本文所引用的出版物是为了引用其在本申请的提交日期之前的公开内容。这里的任何内容都不得解释为承认发明人凭借较早的优先权日期或发明日期而无权早日出版。另外，实际发布日期可能与显示的日期不同，需要独立验证。
定义
术语“胚胎干细胞”或“ES细胞”包括胚胎起源的全能或多能细胞，其能够在引入胚胎后促使发育中的胚胎成为任何组织。术语“多能细胞”包括有能力发育成多于一种分化细胞类型的未分化细胞。
一些靶向载体是“大靶向载体”或“LTVEC”，其包括用于真核细胞的大靶向载体，该大靶向载体包含对应于和来源于这样的核酸序列的同源臂：该核酸序列比由旨在在真核细胞中进行同源基因靶向的其它方法通常使用的那些核酸序列大。LTVEC的示例包括但不限于细菌同源染色体(BAC)和酵母人工染色体(YAC)。使用LTVEC产生靶向基因修饰的示例公开于例如WO 2015/088643、US 2015/0159175、US 2015/0159174、US2014/0310828、US2014/0309487和US 2013-0309670中，这些专利中的每一者出于所有目的全文以引用方式并入本文。LTVEC还包括含有这样的核酸插入物的靶向载体，该核酸插入物具有比由旨在在细胞中进行同源重组的其它方法通常使用的那些核酸序列大的核酸序列。例如，LTVEC使得能够对大基因座进行修饰，而传统的基于质粒的靶向载体由于有大小限制而无法实现这一点。例如，所靶向的基因座可以是(即，5’和3’同源臂可以对应于)在不存在核酸酶试剂(例如，Cas蛋白)诱导的切口或双链断裂的情况下，无法使用常规方法靶向，或仅可不正确地或仅以显著较低效率靶向的细胞基因座。
LTVEC的示例包括来源于细菌人工染色体(BAC)、人类人工染色体或酵母人工染色体(YAC)的载体。LTVEC及其制备方法的非限制性示例描述于例如美国专利6,586,251；美国专利6,596,541；美国专利7,105,348；和WO 2002/036789(PCT/US01/45375)中，这些专利中的每一者均以引用方式并入本文。LTVEC可以是线形形式或环形形式。
LTVEC可为任何长度，包括例如至少10kb或约50kb至约400kb或更长。LTVEC的尺寸可能太大，以致无法通过常规测定法如Southern印迹和长片段(例如，1kb至5kb)PCR来筛选靶向事件。5’同源臂和3’同源臂的总和可为例如至少10kb(每个同源臂均可在例如约5kb至约200kb的范围内)。LTVEC和核酸插入物可被设计成允许在一定长度例如从约5kb至约3Mb(例如，约500kb或更长)的靶基因座处缺失。同样，LTVEC和核酸插入物可被设计成允许在靶基因座中插入一定长度例如在约5kb至约400kb范围内或更长的外源核酸序列。
术语“重组位点”包括由位点特异性重组酶识别且可充当重组事件的底物的核苷酸序列。
术语“位点特异性重组酶”包括一组可有利于“重组位点”之间重组的酶。“位点特异性重组酶”的示例包括但不限于Cre、Flp和Dre重组酶。
指涉核酸序列的术语“种系”包括可传给子代的核酸序列。
短语“可操作地连接”意指组分以其预期方式连接在一起起作用。在一种情况下，编码蛋白的核酸序列可操作地连接至调控序列(例如，启动子、增强子、沉默子序列等)以保持适当的转录调控。在另一种情况下，编码信号肽的核酸序列可操作地连接至编码例如跨膜结构域的核酸序列，以便翻译成包含可操作地融合至跨膜结构域的信号肽的多肽，其中信号肽和跨膜结构域均保持其各自的生物功能。
术语“基因座”被定义为基因组DNA内的DNA片段。例如，DR6基因座为编码DR6的基因组DNA内的DNA片段，并包括与DR6表达相关的未翻译的和/或调控的DNA。
称为死亡受体6(DR6)的TNFR家族成员(在文献中也称为“TR9”；在文献中还称为TNF受体超级族成员21或TNFRS21)已被描述为具有四个细胞外富含半胱氨酸基序和细胞质死亡结构域结构的I类跨膜受体(Pan et al.,FEBS Lett.,431:351-356(1998)(Pan等人，《欧洲生化学会联合会快报》，第431卷，第351-356页，1998年)；另外参见美国专利6,358,508；6,667,390；6,919,078；6,949,358)。已经报道，DR6在某些转染细胞系中的过表达引起NF-kB和JNK两者细胞的凋亡和活化(Pan et al.,FEBS Letters,431:351-356(1998)(Pan等人，《欧洲生化学会联合会快报》，第431卷，第351-356页，1998年))。在DR6缺陷的小鼠模型中，T细胞在JNK活化中大大受损，并且当DR6(-/-)小鼠受蛋白抗原攻击时，发现其T细胞过度增殖并对Th2响应显示出明显的极化(而Th1分化未受到同等程度的影响(Zhao etal.,J.Exp.Med.,194:1441-1448(2001)(Zhao等人，《实验医学杂志》，第194卷，第1441-1448页，2001年))。另外有报道称，DR6的靶向破坏导致辅助性T细胞2(Th2)体外分化增强(如上Zhao等人)。DR6激动剂或拮抗剂在调节B细胞介导的或神经系统病症中的各种用途在2005年3月31日公布的US 2005/0069540和2010年8月12日公布的US 2010/0203044中有所描述。
鼠科动物DR6受体基因座存在于染色体17上并具有6个外显子。它编码具有推定信号序列(第1-41位氨基酸)、胞外结构域(第42-349位氨基酸)、跨膜结构域(第350-370位氨基酸)和胞质结构域(第370-655位氨基酸)的655氨基酸蛋白(SEQ ID NO:16)。成熟DR6蛋白是指其信号蛋白裂解之后的翻译的多肽，例如成熟鼠科动物DR6蛋白是指SEQ ID NO:16的第42-655位氨基酸。
下表1中提供了对由序列编号标识的序列的简单说明。
表2.序列说明。
I.包含至少一种DR6基因座的基因修饰的组合物
提供了非人动物、细胞、组织和胚胎，其包含经修饰的DR6基因座(该基因座缺少编码内源性DR6胞质结构域的任何部分的核苷酸序列)，并且还可包含编码DR6信号肽、跨膜结构域和/或报告基因蛋白的核酸序列。提供了用于操纵DR6表达的方法和组合物。还提供了涉及修饰DR6的靶向组合物。提供了表现出运动神经元功能紊乱(例如与调节DR6功能相关的ALS样表型)的非人动物、细胞和组织。虽然下面的描述是参照某些具体DR6的综述，但所述方法和组合物可与任何DR6一起实施。
本文提供了包含经修饰的DR6基因座和/或核酸的非人动物、细胞、组织和胚胎，其可影响DR6功能或用于DR6基因座中的靶向基因修饰(例如，报告基因敲入)。在这类情况下，经修饰的DR6基因座包含编码DR6的核酸序列中功能突变的丧失。还提供了来源于非人动物的细胞、组织和胚胎，其包含DR6的功能丧失突变。
如涉及DR6的术语“功能丧失”可包括DR6基因座中的任何修饰和/或转基因的表达，导致DR6表达的降低或缺乏和/或DR6活性/功能的降低或缺乏。可以直接(例如通过测定细胞或生物体中DR6的水平)测量DR6的表达水平。
一般来讲，如果DR6表达水平和/或DR6的活性水平在统计学上低于(p≤0.05)尚未经用于抑制DR6的表达和/或活性的基因修饰或诱变的适当对照细胞或生物体中的DR6水平，则该DR6的表达水平和/或活性有所降低。在具体实施方案中，相对于尚未经用以使其具有降低的DR6水平和/或活性的修饰的对照细胞或生物体，该DR6的浓度和/或活性被降低至少1％、5％、10％、20％、30％、40％、50％、60％、70％、80％、90％、95％、99％或更多。
在其它情况下，使用包括但不限于Southern印迹分析、DNA测序、PCR分析或表型分析的方法来选择具有降低DR6的表达水平和/或活性的靶向基因修饰的细胞或生物体。然后将此类细胞或生物体用于本文所述的各种方法和组合物中。
“受试细胞”或“受试生物体”是其中已经实现了基因改变，诸如本文所公开的基因修饰的细胞/生物体，或是为如此改变的细胞/生物体的后代并且包含所述改变的细胞/生物体。“对照”或“对照细胞”或“对照生物体”提供了用于测量受试细胞或生物体的表型变化的参考点。在一个实施方案中，对照细胞/生物体与具有DR6基因修饰的细胞/生物体尽可能接近地匹配，区别为对照细胞/生物体缺乏导致表达和/或活性降低的基因修饰或突变(例如，相应细胞可以源自相同的细胞系)。在其它情况下，对照细胞/生物体可以包括例如：(a)野生型细胞/生物体，即与用于导致受试细胞/生物体中基因改变的起始物质具有相同基因型的细胞/生物体；(b)与起始物质具有相同基因型但已用无效构建体(即用对所关注性状没有已知作用的构建体，诸如包含标记基因的构建体)进行基因修饰的细胞/生物体；(c)作为受试细胞/生物体的非基因修饰后代的细胞/生物体(即，对照细胞和受试细胞源于相同的细胞系)；(d)在遗传上与受试细胞/生物体相同但未暴露于诱导所关注基因表达的条件或刺激下的细胞/生物体；或者(e)在其中基因修饰不会导致所关注多核苷酸的表达改变的条件下的受试细胞/生物体本身。
指涉动物、细胞、组织或胚胎的术语“动物”包括哺乳动物、鱼和鸟。哺乳动物包括，例如，人、非人灵长类动物、猴子、猩猩、猫、狗、马、公牛、鹿、野牛、绵羊、啮齿动物(如，小鼠、大鼠、仓鼠、豚鼠)、牲畜(如，牛物种诸如奶牛、阉牛等；羊物种诸如绵羊、山羊等；和猪物种诸如小猪和公猪)。鸟包括，例如，鸡、火鸡、鸵鸟、鹅、鸭等。还包括驯养的动物和农用动物。指涉动物、细胞、组织或胚胎的短语“非人动物”不包括人。
在一个实施方案中，动物为非人动物。在另一个实施方案中，非人动物为哺乳动物。在另一个实施方案中，哺乳动物为啮齿动物。在另一实施方案中，啮齿动物为小鼠、大鼠或仓鼠。在另一实施方案中，啮齿动物为小鼠或大鼠。在一些实施方案中，啮齿动物为小鼠。
如本文所述的基因修饰可包括DR6基因座中的一种或多种缺失、对DR6基因座的添加、对DR6基因座或其一部分的替换和/或它们的任何组合。基因座可包含编码区或非编码调控区。如本文所述的基因修饰还可包括在DR6基因座之外的基因组中插入转基因，其中转基因的表达妨碍内源性DR6蛋白的配体结合、放置在细胞膜中等，例如与内源性DR6蛋白竞争配体结合、放置在细胞膜中等。
本文提供的基因修饰可靶向DR6基因座。DR6的功能丧失可能是由于DR6基因中的靶向基因修饰(即，调控区、编码区、外显子和/或内含子等中的基因修饰)导致的。此类靶向修饰包括但不限于一个或多个核苷酸的添加，一个或多个核苷酸的缺失，一个或多个核苷酸的取代，DR6基因座的破坏，DR6基因座或其一部分的敲除，DR6基因座或其一部分的敲入，用异源核酸序列替换内源性DR6核酸序列或其一部分，或其组合。在具体实施方案中，改变至少1个、2个、3个、4个、5个、7个、8个、9个、10个、50个、100个、400个或更多个核苷酸，以形成靶向基因组修饰。
在一个实施方案中，功能丧失突变的特征在于至少一种DR6功能的破坏或敲除。
DR6基因座可在基因座的任何区域中进行基因修饰，以使这种修饰能调节DR6功能。在一个实施方案中，DR6基因座的修饰包括整个DR6编码区或其一部分的缺失。在一个实施方案中，经修饰的DR6基因座包括一种或多种编码成熟DR6蛋白或其一部分的外显子的缺失。在另一个实施方案中，这种缺失包括始于DR6基因座的第一、第二、第三、第四、第五和/或第六外显子的DR6基因座内一种或多种外显子的缺失。在其它实施方案中，这种缺失包括始于DR6基因座的第二外显子的DR6基因座内一种或多种外显子的缺失。
在一些情况下，DR6基因座或其一部分被插入核酸替代。在这类情况下，这种替代可为用插入核酸替换DR6基因座的整个RNA编码区或其一部分，用插入核酸替代DR6基因座的一种或多种外显子，用插入核酸替换DR6基因座内的一种或多种外显子(始于DR6基因座的第一外显子)，或者用插入核酸替换DR6基因座内的一种或多种外显子(始于第二外显子)。
在一些情况下，插入核酸被定位在DR6基因座中以致其与内源性DR6启动子可操作地连接，由此使得内源性DR6启动子驱动插入核酸的表达。在这类情况下，核酸序列的表达遵循DR6的表达模式。
在一个实施方案中，DR6基因座或其一部分被包含编码报告基因的第一核酸序列的插入核酸替代。例如，在插入核酸包含报告基因并置于可操作地连接至DR6启动子的DR6基因座中的情况下，报告基因的表达是由内源性DR6启动子驱动的。或者，插入核酸未以与内源性DR6启动子可操作地连接的方式插入。在这类情况下，插入核酸可包含启动子。在一个实施方案中，插入核酸包含可操作地连接至启动子的报告基因，该启动子驱动报告基因的表达。
在一些实施方案中，插入核酸可包含内源性DR6信号序列，例如可定位在DR6基因座中以致其与内源性DR6信号序列和任选内源性DR6跨膜结构域可操作地连接。在这类情况下，由位于DR6基因座外源或在内源性DR6基因座处的插入核酸编码的任何蛋白(例如，报告基因)的目的地类似于DR6的目的地(例如，锚固在例如具有内源性跨膜结构域的膜中)。在一个实施方案中，插入核酸可替代内源性跨膜结构域。在这类和其它情况中，插入核酸可包含编码异源跨膜结构域的第二核酸。在一个实施方案中，插入核酸包含可操作地连接至异源跨膜结构域基因的报告基因，并且插入核酸被插入到可操作地连接至内源性DR6信号序列的DR6基因中，以致插入核酸的表达受内源性DR6启动子驱动，并且由插入核酸编码的蛋白根据信号序列被锚固在膜中。
在一个实施方案中，DR6基因座或其一部分被包含编码选择性标记的另一核酸序列的插入核酸替代。在这类情况下，另一核酸序列可操作地连接至驱动选择性标记表达的启动子。
在另一个实施方案中，DR6基因座或其一部分被包含跨膜基因、报告基因和选择性标记基因的插入核酸替代。在这类情况下，报告基因和/或选择性标记基因可能或可能未可操作地连接至启动子。
在本文别处提供了可用于所述方法和组合物的各种启动子。
这类基因修饰(包括导致靶DR6的表达和/或活性降低或有所调节的那些)也能够通过种系传递。在具体实施方案中，基因修饰导致期望靶基因座敲除。这类非人动物例如可用于如本文别处论述的多种实验系统中。
例如，DR6敲除提供了动物模型来研究DR6功能、DR6在发育的作用和DR6在各种细胞路径和疾病(尤其运动神经元功能紊乱疾病例如ALS)中的作用。
本文提供了用于非人动物、细胞、组织或胚胎中DR6基因座的基因修饰的方法和组合物。
DR6基因座的基因修饰可为如本文别处详细描述的基因座的任何修饰(即缺失、插入、替换等)。在这类情况下，基因修饰导致DR6功能丧失。在一个实施方案中，基因修饰包括DR6的破坏或敲除。
A.报告基因敲入等位基因设计和构建
作为非限制性示例，缺失起始点可设置在第二外显子中以使得插入核酸能够可操作地连接至内源性信号序列。图1示出了编码DR6的全部或大部分序列的靶向缺失并用包含来自ROR1(受体酪氨酸激酶样孤儿受体1)基因的跨膜结构域序列、来自编码β-半乳糖苷酶的大肠杆菌lacZ基因的序列以及表达用于选择G418抗性ES细胞菌落的新霉素磷酸转移酶的盒(neor)替换的示例。允许在表型分析之前Cre介导的切除的LoxP重组酶识别位点位于药物选择盒两侧。
可将LTVEC靶向载体引入ES细胞中，并通过等位基因修饰测定法筛选正确靶向的克隆(Frendewey,D.,et al.(2010),Methods Enzymol 476,295-307(Frendewey,D.等人，2010年，《酶学方法》，第476卷，第295-307页))。
可使用各种方法来鉴定具有靶向修饰诸如缺失或插入的细胞。此类方法可包括鉴定在靶基因座处具有靶向修饰的一个细胞。可完成筛选以鉴定具有经修饰基因组基因座的此类细胞。
筛选步骤可包括用于评估亲本染色体的等位基因(MOA)修饰的定量测定。例如，可经由定量PCR诸如实时PCR(qPCR)进行定量测定。实时PCR可利用识别靶基因座的第一引物组和识别非靶向参考基因座的第二引物组。引物组可包含识别扩增序列的荧光探针。
合适的定量测定法的其它示例包括荧光介导原位杂交(FISH)、比较基因组杂交、等温DNA扩增、定量固定探针杂交、Invader MMP 分子信标、或EclipseTM探针技术(参见例如US2005/0144655，该专利全文以引用方式并入本文)。
方法(Poueymirou,W.T.,et al.(2007),Nat Biotechnol 25,91-99(Poueymirou,W.T.等人，2007年，《自然生物技术》，第25卷，第91-99页))可应用于8细胞胚胎期注射以将靶向ES细胞转化成完全ES细胞起源的F0代杂合小鼠，以便用于lacZ表达分析或将其培育为纯合小鼠。可将携带ZEN-Ub1盒的小鼠培育成Cre清除小鼠品系(参见例如，国际专利申请公布WO 2009/114400)以除去任何floxed neor盒。
在本文的实施例1中提供了用于产生DR6报告基因敲入动物的方法。
B.报告基因表达分析
如本文别处所述，DR6基因座的基因修饰可包括用插入核酸替换DR6基因座或其一部分或向DR6基因座或其一部分插入/添加插入核酸。在一些情况下，插入核酸包含报告基因。在一个实施方案中，报告基因被定位在与内源性DR6启动子可操作地连接的DR6基因座中。这样的修饰允许由内源性DR6启动子驱动报告基因的表达。或者，报告基因未以与内源性DR6启动子可操作地连接的方式放置。
任何报告基因(或可检测部分)可用于熟知的方法和组合物中。报告基因的非限制性示例包括例如，β-半乳糖苷酶(由lacZ基因编码)、绿荧光蛋白(GFP)、增强型绿荧光蛋白(eGFP)、mPlum、mCherry、tdTomato、mStrawberry、J-Red、DsRed、mOrange、mKO、mCitrine、Venus、YPet、增强型黄色荧光蛋白(EYFP)、Emerald、CyPet、青色荧光蛋白(CFP)、Cerulean、T-Sapphire、荧光素酶、碱性磷酸酶或其组合。
本文所述的方法和组合物可在不存在报告基因的情况下或与任何报告基因一起实施。下面的描述是利用编码β-半乳糖苷酶的lacZ报告基因的非限制性示例。
C.表型
内源性DR6基因座的基因修饰可在本文提供的非人动物中产生各种表型。在一个实施方案中，内源性DR6基因座的基因修饰导致在出生时非常正常的非人动物，却在变老之后例如在1周龄之后、在2周龄之后、在3周龄之后、在4周龄之后、在5周龄之后、在6周龄之后、在7周龄之后、在8周龄之后等出现ALS样症状。在另一个实施方案中，内源性DR6基因座的基因修饰导致一种或多种细胞类型(例如神经元和/或神经胶质细胞和/或其一部分例如髓磷脂)功能异常。神经元包括感觉神经元、运动神经元和所有其它通常称为中间神经元的神经元类型。神经胶质细胞包括星形胶质细胞、寡树突胶质细胞等。
术语“ALS样症状”等一般是指“与ALS相关的症状”或“由于上运动神经元和/或下运动神经元功能紊乱导致的症状”。ALS样症状可能涉及神经元(例如运动神经元、感觉神经元和/或中间神经元)损伤。例如，涉及上运动神经元的ALS样症状可导致痉挛状态(例如，痉挛性麻痹、僵直)、反射增强和/或异常(例如，巴宾斯基征)、震颤以及它们的组合。涉及下运动神经元损伤的ALS样症状可导致肌无力和消瘦、肌束震颤以及它们的组合和/或涉及延髓损伤的ALS样症状可导致不能吞咽和舌头肌束震颤。ALS样症状也可包括下列表型中的一者或多者：a)驼背；b)异常后肢抱握、脚趾卷曲拖曳；c)运动协调和运动学习能力缺陷、转杆测试、猫步测试和/或旷场测试缺陷；d)脊髓中运动神经元损失；e)脊髓中星形细胞增多；f)与对照啮齿动物相比体重减轻；g)多泛素化蛋白蛋白积聚；(h)使用ALS-TDI神经系统评分系统所得神经系统评分升高和/或(i)对疼痛刺激的延迟反应时间变长。
ALS-TDI神经系统评分系统
0得分：当小鼠通过其尾悬挂时后腿远离侧向中线完全伸展，并且小鼠可保持这种姿势两秒钟，悬挂两三次。
1得分：后腿朝侧向中线伸展崩溃或部分崩溃(无力)或者后腿在尾悬挂期间发抖。
2得分：脚趾在行走12英寸期间向下卷曲至少两次或脚任何部分沿笼子底部/表面*拖曳。
3得分：僵直麻痹或关节活动最少，未用脚产生向前的运动。
4得分：小鼠在置于身体任一侧后30秒内不能恢复平稳。
II.用于修饰非人动物中内源性DR6基因座的方法
本文提供了用于基因修饰非人动物、细胞、组织或胚胎中内源性DR6基因座的方法。在一个实施方案中，提供了用于修饰多能细胞中DR6基因座的方法。这样的方法包括(a)将包含侧接有5’和3’同源臂的插入核酸的靶向构建体引入多能细胞中，这些同源臂可经历与DR6基因座的同源重组；以及(b)鉴定在DR6基因座处包含靶向基因修饰的经修饰的多能细胞。在这类方法中，基因修饰导致DR6功能丧失。在一个实施方案中，多能细胞为啮齿动物胚胎干细胞。在另一个实施方案中，多能细胞为人类iPS细胞。
A.靶向载体和插入核酸
另外还提供了靶向载体或靶向构建体，在用于产生本文提供的经基因修饰的非人动物、细胞、组织或胚胎的方法中使用。
在一个实施方案中，提供了包含侧接有5’和3’同源臂的插入核酸的靶向载体，这些同源臂可经历与DR6基因座的同源重组。
在下文中详细描述了靶向载体和靶向载体组分(即插入核酸、所关注多核苷酸、表达盒等)的示例。
i.插入核酸
“插入核酸”或“插入多核苷酸”包含希望在靶基因座处整合的DNA片段。在一个实施方案中，插入核酸包含一个或多个所关注多核苷酸。在其它实施方案中，插入核酸可包含一个或多个表达盒。给定表达盒可包含目标多核苷酸、编码选择标记和/或报告基因的多核苷酸，以及影响表达的各种调控组分。
任何所关注多核苷酸都可包含在各种插入多核苷酸中并由此整合在靶基因组基因座处。本文所公开的方法提供整合到所靶向的DR6基因组基因座中的至少1、2、3、4、5、6个或更多个所关注的多核苷酸。
在一个实施方案中，插入核酸中包含的所关注的多核苷酸编码报告基因。在另一个实施方案中，所关注的多核苷酸编码选择性标记。
在一个实施方案中，所关注的多核苷酸可侧接有位点特异性重组位点。在一个特定实施方案中，位点特异性重组位点位于编码报告基因的片段和/或编码选择性标记的片段两侧。
可包含在插入多核苷酸内的所关注的多核苷酸(包括选择标记和报告基因)的非限制性示例在本文别处详细讨论。
当在靶DR6基因座处整合时，插入多核苷酸内的所关注多核苷酸可将一个或多个基因修饰引入细胞中。所述基因修饰可包括缺失内源核酸序列和/或将外源或异源或直系同源多核苷酸添加到靶基因组基因座中。在一个实施方案中，所述基因修饰包括在靶基因组基因座处用所关注的外源多核苷酸替换内源核酸序列。因此，本文所提供的方法允许在靶DR6基因座中生成基因修饰，所述基因修饰包括敲除、缺失、插入、替换(“敲入”)、点突变、结构域交换、外显子交换、内含子交换、调控序列交换、基因交换，或其组合。此类修饰可在第一、第二、第三、第四、第五、第六、第七或任何后续的插入多核苷酸整合到靶基因组基因座中后发生。
在插入多核苷酸内的和/或在靶基因组基因座处整合的所关注多核苷酸可包括对于其被引入的细胞为天然的或同源的序列；所关注多核苷酸对于其被引入的细胞可为异源的；所关注多核苷酸对于其被引入的细胞可为外源的；所关注多核苷酸对于其被引入的细胞可为直系同源的；或者所关注多核苷酸可来自与其被引入的细胞不同的物种。指涉序列的“同源”为对所述细胞天然的序列。指涉序列的术语“异源”为来源于外来物种的序列，或者，如果序列来源于同一物种，则通过有意的人为干预在组成和/或基因组基因座方面从其天然形式进行了实质性修饰。指涉序列的术语“外源”为源于外来物种的序列。术语“直系同源”为来自一种物种的在功能上与另一物种中的已知参考序列等效的多核苷酸(即，物种变体)。所关注的多核苷酸可来自任何所关注的生物体，包括但不限于原核生物、真核生物、非人、啮齿动物、仓鼠、小鼠、大鼠、人、猴、禽、农业哺乳动物或非农业哺乳动物。目标多核苷酸还可包含编码区、非编码区、调控区或基因组DNA。因此，第1、第2、第3、第4、第5、第6、第7和/或后续插入多核苷酸中的任一者可包含此类序列。
在一个实施方案中，如上所述，所关注多核苷酸可在约500个核苷酸至约200kb的范围内。所关注的多核苷酸可以是约500个核苷酸至约5kb，约5kb至约200kb，约5kb至约10kb，约10kb至约20kb，约20kb至约30kb，约30kb至约40kb，约40kb至约50kb，约60kb至约70kb，约80kb至约90kb，约90kb至约100kb，约100kb至约110kb，约120kb至约130kb，约130kb至约140kb，约140kb至约150kb，约150kb至约160kb，约160kb至约170kb，约170kb至约180kb，约180kb至约190kb，或约190kb至约200kb。
在插入多核苷酸内的和/或插入在靶基因组基因座处的所关注多核苷酸可编码多肽，可编码RNA，或者其可包含任何所关注的调控区或非编码区，包括例如调控序列、启动子序列、增强子序列、转录阻遏物结合序列、Kozak共有序列、起始密码子，或非蛋白编码序列的缺失，但不包含蛋白编码序列的缺失。另外，在插入多核苷酸内的和/或插入在靶基因组基因座处的所关注多核苷酸可编码在神经系统、骨骼系统、消化系统、循环系统、肌肉系统、呼吸系统、心血管系统、淋巴系统、内分泌系统、泌尿系统、生殖系统或它们的组合中表达的蛋白。
在一个实施方案中，插入核酸包含内源性基因的至少一个外显子的敲入等位基因。在一个实施方案中，插入核酸包含整个内源性基因的敲入等位基因(即“基因交换敲入”)。
在一个实施方案中，插入核酸包含调控元件，包括例如启动子、增强子或转录阻遏物结合元件。
在进一步的实施方案中，插入核酸包含条件等位基因。在一个实施方案中，条件等位基因为如US 2011/0104799中所述的多功能等位基因，该专利全文以引用的方式并入本文。在具体实施方案中，条件等位基因包含：(a)相对于靶基因的转录呈有义取向的致动序列，以及呈有义或反义取向的药物选择盒；(b)呈反义取向的目标核苷酸序列(NSI)和倒转条件模块(conditional by inversion module)(COIN，其利用外显子断裂内含子和可倒转的基因诱捕样模块；参见，例如US 2011/0104799，该专利全文以引用的方式并入本文)；以及(c)在暴露于第一重组酶后重组以形成条件等位基因的可重组单元，所述条件等位基因(i)缺乏致动序列和DSC，并且(ii)含有呈有义取向的NSI和呈反义取向的COIN。
在一个实施方案中，插入核酸包含编码序列中的基因修饰。在一个实施方案中，基因修饰包括编码序列的缺失突变。在一个实施方案中，基因修饰包括两个内源性编码序列的融合。
在一个实施方案中，基因修饰包括非蛋白编码序列的缺失，但不包括蛋白编码序列的缺失。在一个实施方案中，非蛋白编码序列的缺失包括DR6基因座或其一部分的缺失。在一个实施方案中，非蛋白编码序列的缺失包括调控元件的缺失。在一个实施方案中，基因修饰包括启动子的缺失。在一个实施方案中，基因修饰包括启动子或调控元件的添加。在一个实施方案中，基因修饰包括启动子或调控元件的替换。
在一个实施方案中，靶向载体的核酸序列可包含多核苷酸，当所述多核苷酸被整合至基因组时将产生哺乳动物、非人动物或非人哺乳动物DR6基因座区域的基因修饰，其中在DR6基因座处的基因修饰导致DR6功能丧失。在一个实施方案中，生成了DR6敲除(“无效等位基因”)。在另一个实施方案中，生成了DR6基因座的破坏。
在另外的实施方案中，插入核酸导致哺乳动物、非人动物或非人哺乳动物DR6基因座的一部分被插入核酸序列替换。在一个实施方案中，插入核酸序列为报告基因核酸序列。
给定插入多核苷酸以及哺乳动物、非人或非人哺乳动物基因座被替换的对应区域可为非编码区、编码区、内含子、外显子、非翻译区、调控区、启动子、增强子或它们的任何组合。此外，给定插入多核苷酸和/或哺乳动物、非人或非人哺乳动物基因座所缺失的区域可以是任何期望的长度，包括例如在10至100个核苷酸之间的长度、100至500个核苷酸的长度、500个至1kb核苷酸的长度、1kb至1.5kb核苷酸的长度、1.5kb至2kb核苷酸的长度、2kb至2.5kb核苷酸的长度、2.5kb至3kb核苷酸的长度、3kb至5kb核苷酸的长度、5kb至8kb核苷酸的长度、8kb至10kb核苷酸的长度或更长。在其它情况中，插入或替换的大小为约5kb至约10kb，约10kb至约20kb，约20kb至约40kb，约40kb至约60kb。在其它实施方案中，给定插入多核苷酸和/或哺乳动物、人细胞或非人哺乳动物基因座所缺失的区域为至少100、200、300、400、500、600、700、800或900个核苷酸或至少1kb、2kb、3kb、4kb、5kb、6kb、7kb、8kb、9kb、10kb、11kb、12kb、13kb、14kb、15kb、16kb、17kb、18kb、19kb、20kb、25kb、30kb、35kb、40kb、45kb、50kb或更大。
在一个实施方案中，插入核酸被插入到所关注的DR6基因座中，使得其可操作地连接至内源性DR6启动子。在这类情况下，DR6启动子驱动插入核酸序列的表达。在一个实施方案中，插入核酸序列为报告基因核酸序列。
在一些情况下，插入核酸包含启动子。在一个实施方案中，插入核酸包含可操作地连接至启动子的所关注多核苷酸，该启动子驱动所关注多核苷酸的表达。在一个实施方案中，所关注多核苷酸包含报告基因核酸序列。在另一个实施方案中，所关注多核苷酸包含选择标记核酸序列。
在一个实施方案中，启动子为组成型活性启动子。
在一个实施方案中，启动子为诱导型启动子。在一个实施方案中，诱导型启动子为化学调控的启动子。在一个实施方案中，化学调控的启动子为醇调控的启动子。在一个实施方案中，醇调控的启动子为醇脱氢酶(alcA)基因启动子。在一个实施方案中，化学调控的启动子为四环素调控的启动子。在一个实施方案中，四环素调控的启动子为四环素应答型启动子。在一个实施方案中，四环素调控的启动子为四环素操纵子序列(tetO)。在一个实施方案中，四环素调控的启动子为tet-On启动子。在一个实施方案中，四环素调控的启动子为tet-Off启动子。在一个实施方案中，化学调控的启动子为类固醇调控的启动子。在一个实施方案中，类固醇调控的启动子为大鼠糖皮质素受体的启动子。在一个实施方案中，类固醇调控的启动子为雌激素受体的启动子。在一个实施方案中，类固醇调控的启动子为蜕皮激素受体的启动子。在一个实施方案中，化学调控的启动子为金属调控的启动子。在一个实施方案中，金属调控的启动子为金属蛋白启动子。在一个实施方案中，诱导型启动子为物理调控的启动子。在一个实施方案中，物理调控的启动子为温度调控的启动子。在一个实施方案中，温度调控的启动子为热激启动子。在一个实施方案中，物理调控的启动子为光调控的启动子。在一个实施方案中，光调控的启动子为光诱导型启动子。在一个实施方案中，光调控的启动子为光阻抑型启动子。
在一个实施方案中，启动子为组织特异性启动子。在一个实施方案中，启动子为神经元特异性启动子。在一个实施方案中，启动子为神经胶质特异性启动子。在一个实施方案中，启动子为肌细胞特异性启动子。在一个实施方案中，启动子为心脏细胞特异性启动子。在一个实施方案中，启动子为肾细胞特异性启动子。在一个实施方案中，启动子为骨细胞特异性启动子。在一个实施方案中，启动子为内皮细胞特异性启动子。在一个实施方案中，启动子为免疫细胞特异性启动子。在一个实施方案中，免疫细胞启动子为B细胞启动子。在一个实施方案中，免疫细胞启动子为T细胞启动子。
在一个实施方案中，启动子为发育调控的启动子。在一个实施方案中，发育调控的启动子只在发育的胚胎期有活性。在一个实施方案中，发育调控的启动子只在成体细胞中有活性。
在特定实施方案中，可根据细胞类型选择启动子。因此，各种启动子可用于真核细胞、哺乳动物细胞、非人类哺乳动物细胞、多能细胞、非人类多能细胞、人类多能细胞、人类ES细胞、人类成体干细胞、发育受限的人类祖细胞、人类iPS细胞、人类细胞、啮齿动物细胞、大鼠细胞、小鼠细胞、仓鼠细胞、成纤维细胞或CHO细胞。
在一些实施方案中，插入核酸包含侧接有位点特异性重组靶序列的核酸。已经认识到，虽然整个插入核酸可侧接有这种位点特异性重组靶序列，但该插入核酸内的所关注的任何区域或单独多核苷酸也可侧接此类位点。位点特异性重组酶可通过任何方式引入细胞中，包括将重组酶多肽引入细胞中或将编码位点特异性重组酶的多核苷酸引入宿主细胞中。编码位点特异性重组酶的多核苷酸可位于插入核酸内或单独的多核苷酸内。位点特异性重组酶可操作地连接至细胞中有活性的启动子，包括例如诱导型启动子、对于细胞为内源的启动子、对于细胞为异源的启动子、细胞特异性启动子、组织特异性启动子或发育阶段特异性启动子。可侧接插入核酸或插入核酸中的任何目标多核苷酸的位点特异性重组靶序列可包括但不限于loxP、lox511、lox2272、lox66、lox71、loxM2、lox5171、FRT、FRT11、FRT71、attp、att、FRT、rox或它们的组合。
在一些实施方案中，位点特异性重组位点侧接插入核酸内所含的编码选择标记物和/或报告基因的多核苷酸。在此类情况下，在所靶向基因座处整合插入核酸之后，可除去位点特异性重组位点之间的序列。
在一个实施方案中，插入核酸包含编码选择标记的多核苷酸。选择标记物可以包含在选择盒中。此类选择标记包括但不限于新霉素磷酸转移酶(neor)、潮霉素B磷酸转移酶(hygr)、嘌呤霉素-N-乙酰转移酶(puror)、杀稻瘟菌素S脱氨酶(bsrr)、黄嘌呤/鸟嘌呤磷酸核糖转移酶(gpt)或单纯疱疹病毒胸苷激酶(HSV-k)，或者它们的组合。在一个实施方案中，编码选择标记的多核苷酸可操作地连接至细胞中有活性的启动子。在一个实施方案中，编码选择标记的多核苷酸侧接有位点特异性重组靶序列。
插入核酸还可包含可操作地连接至启动子的报告基因，其中所述报告基因编码报告基因蛋白，所述报告基因蛋白选自或包括β-半乳糖苷酶(由lacZ基因编码)、GFP、mPlum、mCherry、tdTomato、mStrawberry、J-Red、DsRed、mOrange、mKO、mCitrine、Venus、YPet、增强型黄色荧光蛋白(EYFP)、Emerald、增强型绿色荧光蛋白(EGFP)、CyPet、青色荧光蛋白(CFP)、Cerulean、T-Sapphire、荧光素酶、碱性磷酸酶以及/或者它们的组合。此类报告基因可操作地连接至在细胞中有活性的启动子。此类启动子可为诱导型启动子、对于报告基因或细胞为内源的启动子、对于报告基因或细胞为异源的启动子、细胞特异性启动子、组织特异性启动子或发育阶段特异性启动子。
ii.表达盒
本文提供了多核苷酸或核酸分子，其包含本文用于靶向DR6基因座而提供的靶向基因组整合系统中采用的各种组分(即，核酸酶试剂、识别位点、插入核酸、所关注多核苷酸、报告序列、靶向载体、选择标记和其它组分中的任一者或任何组合)。
术语“多核苷酸”、“多核苷酸序列”、“核酸序列”和“核酸片段”可在本文中互换使用。这些术语涵盖核苷酸序列等。多核苷酸可为任选含有合成、非天然或改变的核苷酸碱基的单链或双链的RNA或DNA聚合物。DNA聚合物形式的多核苷酸可由cDNA、基因组DNA、合成DNA或它们的混合物的一个或多个区段构成。多核苷酸可包含脱氧核糖核苷酸和核糖核苷酸，其包括天然存在的分子和合成类似物两者以及这些的任何组合。本文提供的多核苷酸还涵盖所有形式的序列，包括但不限于单链形式、双链形式、发夹、茎-环结构等。
还提供了重组多核苷酸，其包含用于靶向DR6基因座的靶向基因组整合系统的各种组分。术语“重组多核苷酸”和“重组DNA构建体”可在本文中互换使用。重组构建体包含核酸序列的人工或异源组合，例如自然界中不共存的调控序列和编码序列。在其它实施方案中，重组构建体可包含来源于不同来源的调控序列和编码序列，或来源于相同来源但以与自然界中的存在方式不同的方式排列的调控序列和编码序列。这种构建体可独自使用或可结合载体使用。如果使用载体，则载体的选择取决于如本领域技术人员众所周知的用以转化宿主细胞的方法。例如，可使用质粒载体。还提供了成功转化、选择和繁殖宿主细胞所需的且包含本文提供的分离核酸片段中的任一种的遗传元件。筛选可尤其通过DNA的Southern分析、mRNA表达的Northern分析、蛋白表达的免疫印迹分析或表型分析来实现。
在具体实施方案中，本文所述的用于靶向DR6基因座的靶向基因组整合系统的组分中的一者或多者可提供于表达盒中，以便在原核细胞、真核细胞、细菌、酵母细胞或哺乳动物细胞或其它目标生物体或细胞类型中表达。所述盒可包括可操作地连接至本文所提供的多核苷酸的5'调控序列和3'调控序列。“可操作地连接”包括其中组分以其预期方式可操作地连接功能的关系。例如，目标多核苷酸与调控序列(即，启动子)之间的可操作地连接为允许表达目标多核苷酸的功能性连接。可操作地连接的元件可为邻接的或不邻接的。当用以提到两个蛋白编码区的连接时，可操作地连接意指编码区在同一阅读框中。在另一种情况下，编码蛋白的核酸序列可操作地连接至调控序列(例如，启动子、增强子、沉默子序列等)以保持恰当的转录调控。所述盒可另外含有将共同引入生物体中的至少一个额外目标多核苷酸。或者，所述额外目标多核苷酸可提供于多个表达盒上。这种表达盒提供有多个限制位点和/或重组位点，以使重组多核苷酸的插入处于调控区的转录调控之下。所述表达盒可另外含有选择标记基因。
所述表达盒在5'-3'转录方向上可包含在哺乳动物细胞或目标宿主细胞中起作用的转录和翻译起始区(即，启动子)、本文所提供的重组多核苷酸、以及转录和翻译终止区(即，终止区)。所述调控区(即，启动子、转录调控区、Kozak序列和翻译终止区)和/或本文所提供的多核苷酸对于宿主细胞或对于彼此可为天然/类似的。另选地，所述调控区和/或本文所提供的多核苷酸对于宿主细胞或对于彼此可为异源的。例如，可操作地连接至异源多核苷酸的启动子来自与得到该多核苷酸的物种不同的物种，或者如果来自相同/类似的物种，则对一者或两者由其原始形式和/或基因组基因座进行了实质性修饰，或者启动子不是可操作地连接的多核苷酸的天然启动子。另选地，所述调控区和/或本文所提供的重组多核苷酸可以是完全合成的。
所述终止区对于转录起始区而言可为天然的，对于可操作地连接的重组多核苷酸而言可为天然的，对于宿主细胞而言可为天然的，或者可来源于对于启动子、重组多核苷酸、宿主细胞或它们的任何组合而言为另一种的(即，外来的或异源的)来源。
在制备表达盒时，可对各种DNA片段进行操纵，以便提供处于正确取向的DNA序列。为此目的，可采用衔接子或接头将DNA片段连接在一起，或者可涉及其它的操纵以提供便利的限制性位点、去除多余的DNA、去除限制性位点等。出于这个目的，可能涉及体外诱变、引物修复、限制性酶切、退火、再置换(例如转换和颠换)。
多种启动子可用于本文所提供的表达盒中。可根据期望的结果来选择启动子。已经认识到，不同的应用可通过在表达盒中使用不同的启动子来增强，从而调整目标多核苷酸的表达的时机、位置和/或水平。如果需要，此类表达构建体还可含有启动子调控区(例如，赋予可诱导的、组成型的、环境或发育调控的，或细胞或组织特异性/选择性表达的启动子调控区)、转录起始位点、Kozak共有序列、核糖体结合位点、RNA加工信号、转录终止位点和/或多聚腺苷酸化信号。
含有本文所提供的多核苷酸的表达盒还可包含用于选择转化细胞的选择标记基因。利用选择性标记基因来选择转化细胞或组织。
在适当的情况下，可优化在所述方法和组合物(即，目标多核苷酸、核酸酶试剂等)中采用的序列，以便增加在细胞中的表达。也就是说，所述基因可使用给定目标细胞中偏好的密码子来合成以便提高表达，所述密码子包括例如哺乳动物偏好密码子、人偏好密码子、啮齿动物偏好密码子、小鼠偏好密码子、大鼠偏好密码子、仓鼠偏好密码子等。
本文提供的各种方法和组合物均可采用选择标记。可在本文所公开的方法和组合物中使用各种选择标记。此类选择标记可例如赋予对抗生素如G418、潮霉素、杀稻瘟菌素、新霉素或嘌呤霉素的抗性。此类选择标记包括新霉素磷酸转移酶(neor)、潮霉素B磷酸转移酶(hygr)、嘌呤霉素-N-乙酰转移酶(puror)以及杀稻瘟菌素S脱氨酶(bsrr)。在另一些实施方案中，选择标记可操作地连接至诱导型启动子，并且选择标记的表达对细胞有毒性。此类选择标记的非限制性示例包括黄嘌呤/鸟嘌呤磷酸核糖转移酶(gpt)、次黄嘌呤-鸟嘌呤磷酸核糖转移酶(HGPRT)或单纯疱疹病毒胸苷激酶(HSV-TK)。编码选择标记的多核苷酸可操作地连接至细胞中有活性的启动子。
iii.靶向载体
采用靶向载体将插入核酸引入真核生物、非人类、哺乳动物、非人类哺乳动物、人类、啮齿动物、小鼠、大鼠或仓鼠核酸的DR6基因座中。靶向载体包含插入核酸，并且还包含5'同源臂和3'同源臂，这些同源臂侧接插入核酸。侧接插入核酸的同源臂对应于真核生物、非人类、哺乳动物、非人类哺乳动物、人类、啮齿动物、小鼠、大鼠或仓鼠核酸的靶DR6基因座内的区域。为了便于提及，所靶向基因组基因座内的对应同源基因组区域称为“靶位点”。例如，靶向载体可包含侧接有与第一靶位点和第二靶位点互补的第一同源臂和第二同源臂的第一插入核酸。因此，靶向载体由此有助于通过在细胞的基因组内的同源臂与互补靶位点之间发生的同源重组事件，将插入核酸整合到靶基因座核酸中。
在一个实施方案中，真核生物、哺乳动物、非人类哺乳动物、人类、啮齿动物、小鼠或仓鼠核酸的靶基因座包含与5’同源臂互补的第一核酸序列和与3’同源臂互补的第二核酸序列。在一个实施方案中，第一核酸序列和第二核酸序列间隔至少5kb。在另一个实施方案中，第一核酸序列和第二核酸序列间隔至少1kb但不超过50kb。在一个实施方案中，第一核酸序列和第二核酸序列间隔至少2kb。在一个实施方案中，第一核酸序列和第二核酸序列间隔至少3kb、至少4kb、至少5kb、至少6kb、至少7kb、至少8kb、至少9kb、至少10kb、至少15kb、至少20kb、至少30kb、至少40kb或至少50kb。在另外的实施方案中，第一核酸序列和第二核酸序列间隔至少1kb但不超过2kb、至少2kb但不超过3kb、至少4kb但不超过5kb、至少5kb但不超过6kb、至少6kb但不超过7kb、至少7kb但不超过8kb、至少约8kb但不超过9kb、至少9kb但不超过10kb，或者至少10kb但不超过15kb、至少约15kb但不超过约20kb、至少约20kb但不超过约30kb，或至少约40kb但不超过约50kb。
靶向载体的同源臂可具有足以促进与对应靶位点的同源重组事件的任何长度，包括例如至少5-10kb、5-15kb、10-20kb、20-30kb、30-40kb、40-50kb、50-60kb、60-70kb、70-80kb、80-90kb、90-100kb、100-110kb、110-120kb、120-130kb、130-140kb、140-150kb、150-160kb、160-170kb、170-180kb、180-190kb、190-200kb的长度或更长。如下文进一步详细概述，大靶向载体可采用更大长度的靶向臂。在一个具体实施方案中，5'同源臂和3'同源臂的总和为至少10kb，或者5'同源臂和3'同源臂的总和为至少约16kb至约100kb或约30kb至约100kb。在其它实施方案中，LTVEC的总5'和3'同源臂的总和大小为约10kb至约150kb，约10kb至约100kb，约10kb至约75kb，约20kb至约150kb，约20kb至约100kb，约20kb至约75kb，约30kb至约150kb，约30kb至约100kb，约30kb至约75kb，约40kb至约150kb，约40kb至约100kb，约40kb至约75kb，约50kb至约150kb，约50kb至约100kb，或者约50kb至约75kb，约10kb至约30kb，约20kb至约40kb，约40kb至约60kb，约60kb至约80kb，约80kb至约100kb，约100kb至约120kb，或约120kb至约150kb。在一个实施方案中，缺失的大小与LTVEC的5'和3'同源臂的总和大小相同或近似。
当两个区域彼此共有足够水平的序列同一性时，同源臂和靶位点(即同源基因组区域)彼此“互补”，从而充当同源重组反应的底物。“同源性”意指DNA序列与对应或“互补”序列相同或共有序列同一性。给定靶位点与存在于靶向载体上的对应同源臂之间的序列同一性可为允许同源重组发生的任何程度的序列同一性。例如，靶向载体的同源臂(或其片段)与靶位点(或其片段)共有的序列同一性的量可为至少50％、55％、60％、65％、70％、75％、80％、81％、82％、83％、84％、85％、86％、87％、88％、89％、90％、91％、92％、93％、94％、95％、96％、97％、98％、99％或100％序列同一性，以使得所述序列经历同源重组。此外，同源臂与互补靶位点之间的互补同源区可具有足以促进在裂解的识别位点处同源重组的任何长度。例如，给定同源臂和/或互补靶位点可包含互补同源区，该互补同源区为至少5-10kb、5-15kb、10-20kb、20-30kb、30-40kb、40-50kb、50-60kb、60-70kb、70-80kb、80-90kb、90-100kb、100-110kb、110-120kb、120-130kb、130-140kb、140-150kb、150-160kb、160-170kb、170-180kb、180-190kb、190-200kb、200kb至300kb的长度或更长(诸如在本文别处描述的LTVEC载体中所述)，以使得同源臂与在细胞基因组内的对应靶位点具有足以经历同源重组的同源性。为了易于参考，同源臂在本文中称为5’和3’同源臂。该术语涉及靶向载体内的同源臂与插入核酸的相对位置。
靶向载体的同源臂因此被设计成与具有所靶向基因座的靶位点互补。因此，同源臂可与对细胞为天然的基因座互补，或者另选地，它们可与整合到细胞基因组中的异源或外源DNA区段的区域互补，所述区域包括但不限于转基因、表达盒或者异源或外源基因组DNA区域。另选地，靶向载体的同源臂可与人类人工染色体的区域或在适当宿主细胞中包含的任何其它经改造的基因组区域互补。更进一步，靶向载体的同源臂可与BAC文库、粘粒文库或P1噬菌体文库的区域互补，或者可来源于BAC文库、粘粒文库或P1噬菌体文库的区域。因此，在特定实施方案中，靶向载体的同源臂与对给定细胞为天然、异源或外源的真核生物、非人类、哺乳动物、非人类哺乳动物、人类、啮齿动物、小鼠或大鼠基因组基因座互补。在一个实施方案中，同源臂来源于合成DNA。
靶向载体(诸如大靶向载体)还可包含如本文别处所讨论的选择盒或报告基因。选择盒可包含编码选择标记的核酸序列，其中所述核酸序列可操作地连接至如本文别处所讨论的启动子。靶向载体的选择标记和/或报告基因可侧接有5'同源臂和3'同源臂，或可存在于同源臂的5’或3’。
在一个实施方案中，靶向载体包含插入核酸，该插入核酸包含编码报告基因的第一核苷酸序列。在一些情况下，在与DR6基因座同源重组之后，编码报告基因的第一核苷酸序列可操作地连接至驱动DR6在DR6基因座处表达的内源启动子。
在另一个实施方案中，靶向载体包含插入核酸，该插入核酸包含编码跨膜结构域并与编码报告基因的第二核苷酸序列可操作地连接的第一核苷酸序列。在一些情况下，在与DR6基因座同源重组之后，编码跨膜结构域的第一核苷酸序列可操作地连接至驱动跨膜结构域和报告基因到达目的地的内源DR6信号序列。
在另一个实施方案中，靶向载体的插入核酸包含另外的编码选择性标记的核苷酸序列。在一些情况下，所述另外的核酸可操作地连接至启动子。
在一个实施方案中，插入核酸的第一和/或另外的核苷酸序列包含Kozak共有序列。
在一个实施方案中，靶向载体(诸如大靶向载体)包含可操作地连接至如本文别处描述的启动子的报告基因和/或选择性标记基因。这类报告基因和/或选择性标记基因可操作地连接至在如本文别处描述的细胞中有活性的启动子。
在一个实施方案中，靶向载体包含位点特异性重组酶基因。在一个实施方案中，位点特异性重组酶基因编码Cre重组酶。在一个实施方案中，Cre重组酶基因为Crei，其中编码Cre重组酶的两个外显子由内含子隔开以防止其在原核细胞中表达。在一个实施方案中，位点特异性重组酶基因编码Dre重组酶。
在一个实施方案中，Cre重组酶基因还包含核定位信号以利于将Cre(或任何重组酶或核酸酶试剂)定位至核(例如，基因为NLS-Cre基因)。在一个特定实施方案中，Cre重组酶基因还包含核定位信号(NLS)和内含子(例如，NLS-Crei)。
在各种实施方案中，用于表达上述Cre或Crei重组酶的合适的启动子选自或包括Prm1、Blimp1、Gata6、Gata4、Igf2、Lhx2、Lhx5和/或Pax3。在一个具体实施方案中，启动子为Gata6或Gata4启动子。各种启动子可来自任何生物体，包括例如，啮齿动物诸如小鼠或大鼠、真核生物、非人类哺乳动物、哺乳动物、人类或仓鼠。在另一个特定实施方案中，启动子为Prm1启动子。在另一个特定实施方案中，启动子为小鼠Prm1启动子。在另一个特定实施方案中，启动子为Blimp1启动子或其片段，例如，Blimp1启动子的1kb或2kb片段。参见例如美国专利8,697,851、美国专利9,267,152、美国专利9,096,870、美国专利8,354,389、美国专利8,946,505、美国专利8,946,504、美国专利8,518,392，这些专利中的每一篇均全文以引用方式并入本文。
在一个实施方案中，插入核酸包含侧接有两个位点特异性重组位点的核苷酸序列。位点特异性重组位点的示例包括但不限于loxP、lox511、lox2272、lox66、lox71、loxM2、lox5171、FRT、FRT11、FRT71、attp、att、FRT、rox以及它们的组合。
iv.大靶向载体
术语“大靶向载体”或“LTVEC”包括这样的大靶向载体：其包含对应于且来源于一些核酸序列的同源臂，这些核酸序列比通常由意欲在细胞中进行同源靶向的其它方法使用的那些核酸序列大；并且/或者包含插入多核苷酸，所述插入多核苷酸包含的核酸序列比通常由意欲在细胞中进行同源重组靶向的其它方法使用的那些核酸序列大。在具体实施方案中，LTVEC的同源臂和/或插入多核苷酸包含真核细胞的基因组序列。LTVEC的尺寸太大，无法通过常规测定法例如Southern印迹和长片段(例如，1kb-5kb)PCR来筛选靶向事件。LTVEC的示例包括但不限于衍生自细菌人工染色体(BAC)、人类人工染色体或酵母人工染色体(YAC)的载体。LTVEC及其制备方法的非限制性示例描述于例如美国专利6,586,251、6,596,541、7,105,348和WO 2002/036789(PCT/US01/45375)中，这些专利中每一篇均以引用方式并入本文。
LTVEC可具有任何长度，包括但不限于至少约10kb，约15kb，约20kb，约30kb，约40kb，约50kb，约60kb，约70kb，约80kb，约90kb，约100kb，约150kb，约200kb，约10kb至约15kb，约15kb至约20kb，约20kb至约30kb，约30kb至约50kb，约50kb至约300kb，约50kb至约75kb，约75kb至约100kb，约100kb至125kb，约125kb至约150kb，约150kb至约175kb，约175kb至约200kb，约200kb至约225kb，约225kb至约250kb，约250kb至约275kb，或约275kb至约300kb。
在一个实施方案中，LTVEC的同源臂来源于BAC文库、粘粒文库或P1噬菌体文库。在其它实施方案中，同源臂来源于细胞的所靶向DR6基因组基因座，并且在一些情况下，LTVEC被设计用来靶向的靶基因组基因座无法使用常规方法靶向。在另一些实施方案中，同源臂来源于合成DNA。
在一个实施方案中，LTVEC中的上游同源臂和下游同源臂的总和为至少10kb。在其它实施方案中，上游同源臂在约5kb至约100kb的范围内。在一个实施方案中，下游同源臂在约5kb至约100kb的范围内。在其它实施方案中，上游和下游同源臂的总和为约5kb至约10kb，约10kb至约20kb，约20kb至约30kb，约30kb至约40kb，约40kb至约50kb，约50kb至约60kb，约60kb至约70kb，约70kb至约80kb，约80kb至约90kb，约90kb至约100kb，约100kb至约110kb，约110kb至约120kb，约120kb至约130kb，约130kb至约140kb，约140kb至约150kb，约150kb至约160kb，约160kb至约170kb，约170kb至约180kb，约180kb至约190kb，或约190kb至约200kb。在一个实施方案中，缺失的大小与LTVEC的5'和3'同源臂的总和大小相同或近似。
在一个实施方案中，LTVEC包含选择盒或报告基因，如本文别处所讨论。
III.引入序列并产生转基因动物的方法
如上所概述，本文提供了允许DR6基因座的所靶向基因修饰的方法和组合物。还认识到，可以进行另外的所靶向基因修饰。允许这些所靶向基因修饰的此类系统可采用多种组分，并且为了便于提及，在本文中术语“靶向基因组整合系统”通常包括整合事件所需的所有组分(即，各种核酸酶试剂、识别位点、插入DNA多核苷酸、靶向载体、靶基因组基因座和所关注多核苷酸)。
本文所提供的方法包括向细胞中引入包含靶向基因组整合系统的各种组分的一个或多个多核苷酸或多肽构建体。“引入”意指以使得序列(多肽或多核苷酸)能够进入细胞内部的方式将序列呈递到细胞。本文所提供的方法并不取决于将靶向基因组整合系统的任何组分引入细胞中的特定方法，只要使多核苷酸能够进入至少一个细胞内部即可。用于将多核苷酸引入到各种细胞类型中的方法是本领域已知的，并且包括但不限于稳定转染方法、瞬时转染方法和病毒介导的方法。
在一些实施方案中，在所述方法和组合物中采用的细胞具有稳定地掺入到其基因组中的DNA构建体。“稳定地掺入”或“稳定地引入”意指将多核苷酸引入到细胞中，使得核苷酸序列整合到细胞的基因组中且能够遗传给其子代。可使用任何方案稳定地掺入DNA构建体或靶向基因组整合系统的各种组分。
转染方案以及将多肽或多核苷酸序列引入到细胞中的方案可有所差别。非限制性转染方法包括基于化学的转染方法，其包括使用：脂质体；纳米粒子；磷酸钙(Graham etal.(1973).Virology 52(2):456-67(Graham等人，1973年，《病毒学》，第52卷，第2期，第456-467页)；Bacchetti et al.(1977)Proc Natl Acad Sci USA 74(4):1590-4(Bacchetti等人，1977年，《美国科学院院刊》，第74卷，第4期，第1590-1594页)；以及Kriegler,M(1991).Transfer and Expression:A Laboratory Manual.New York:W.H.Freeman and Company.pp.96-97)(Kriegler,M，1991年，《基因转染和表达实验手册》，纽约W.H.弗里曼公司，第96-97页))；树枝状体；或阳离子聚合物，诸如DEAE-葡聚糖或聚乙烯亚胺。非化学方法包括电穿孔、超声穿孔和光学转染。基于颗粒的转染包括使用基因枪、磁体辅助转染(Bertram,J.(2006)Current Pharmaceutical Biotechnology 7,277-28(Bertram,J.，2006年，《当今药物生物技术》，第7卷，第277-28页))。也可将病毒方法用于转染。
可采用本文所公开的各种方法产生非人动物。此类方法包括(1)采用本文所公开的方法在非人动物多能细胞的所关注靶DR6基因组基因座处整合一个或多个所关注多核苷酸，以生成在所靶向DR6基因组基因座中包含插入多核苷酸的经基因修饰的多能细胞；(2)选择在靶DR6基因组基因座处具有一个或多个所关注多核苷酸的经基因修饰的多能细胞；(3)将经基因修饰的多能细胞引入到例如处于桑椹胚前期的非人动物宿主胚胎中；以及(4)将包含经基因修饰的多能细胞的宿主胚胎植入代孕母体中，以产生来源于经基因修饰的多能细胞的F0代。可采用类似的方法来靶向具有挑战性的靶染色体基因座。所述非人动物可为非人哺乳动物、啮齿动物、小鼠、大鼠、仓鼠、猴、农业哺乳动物或家养哺乳动物，或者鱼或鸟。
所述多能细胞可为人ES细胞、非人ES细胞、啮齿动物ES细胞、小鼠ES细胞、大鼠ES细胞、仓鼠ES细胞、猴ES细胞、农业哺乳动物ES细胞或家养哺乳动物ES细胞。在其它实施方案中，所述多能细胞为非人类细胞、哺乳动物细胞、人类细胞、非人类哺乳动物细胞、人类多能细胞、人类ES细胞、人类成体干细胞、发育受限的人类祖细胞、人类iPS细胞、啮齿动物细胞、大鼠细胞、小鼠细胞、仓鼠细胞。在一个实施方案中，所靶向基因修饰导致DR6的功能丧失。
小鼠多能细胞、全能细胞或宿主胚胎可来自任何小鼠品系，包括例如近交品系、杂交品系和远交品系。小鼠品系的示例包括129品系、C57BL品系(例如，C57BL/6品系)、129和C57BL/6的混合(例如，50％129和50％C57BL/6)、BALB/c品系和Swiss Webster品系。129品系的示例包括129P1、129P2、129P3、129X1、129S1(例如，12951/SV、12951/SvIm)、129S2、129S4、129S5、12959/SvEvH、129S6(129/SvEvTac)、129S7、129S8、129T1和129T2(参见例如，Festing et al.(1999)Revised nomenclature for strain 129 mice,Mammalian Genome10:836(Festing等人，1999年，“品系129小鼠的修订命名法”，《哺乳动物基因组》，第10卷，第836页))。C57BL品系的示例包括C57BL/A、C57BL/An、C57BL/GrFa、C57BL/KaLwN、C57BL/6、C57BL/6J、C57BL/6ByJ、C57BL/6NJ、C57BL/10、C57BL/10ScSn、C57BL/10Cr和C57BL/01a。小鼠可为上述129品系(例如，129S6(129/SvEvTac)品系)和上述C57BL/6品系的混合、一种或多种上述129品系的混合，或一种或多种上述C57BL品系的混合。小鼠也可来自除129品系之外的品系。
大鼠多能细胞、全能细胞或宿主胚胎可来自任何大鼠品系，包括例如近交品系、杂交品系和远交品系。大鼠品系的示例包括ACI大鼠品系、黑刺(DA)大鼠品系、威斯塔鼠品系、LEA大鼠品系、Sprague Dawley(SD)大鼠品系，或者Fischer大鼠品系诸如Fisher F344或Fisher F6。大鼠多能细胞、全能细胞或宿主胚胎还可获自来源于以上列举的两种或更多种品系的混合的品系。例如，大鼠多能细胞、全能细胞或宿主胚胎可来源于选自DA品系和ACI品系的品系。ACI大鼠品系的特点是具有黑刺、白色的腹和足，为RT1av1单倍型。此类品系得自多种来源，包括Harlan实验室。来自ACI大鼠的大鼠ES细胞系的示例为ACI.G1大鼠ES细胞。黑刺(DA)大鼠品系的特点是具有花纹外皮并且为RT1av1单倍型。此类大鼠得自多种来源，包括查尔斯河(Charles River)和Harlan实验室。来自DA大鼠的大鼠ES细胞系的示例为DA.2B大鼠ES细胞系或DA.2C大鼠ES细胞系。大鼠品系的其它示例提供于例如US 2014/0235933、US 2014/0310828和US2014/0309487中，这些专利中的每一篇出于所有目的全文以引用方式并入本文。
例如，可生殖系传递的大鼠ES细胞可通过在具有培养基的饲养细胞层上培养分离的大鼠ES细胞获得，该培养基包含N2补充剂、B27补充剂、约50U/mL至约150U/mL白血病抑制因子(LIF)和由MEK抑制剂和GSK3抑制剂组成的抑制剂组合，其中饲养细胞层未经修饰来表达LIF，并且其中大鼠ES细胞：(i)已经过修饰以包含所靶向基因修饰并能够通过种系传递所述所靶向基因修饰，该所靶向基因修饰包括至少一个包含选择标记的异源多核苷酸插入到大鼠ES细胞的基因组中；(ii)具有正常核型；(iii)缺少c-Myc表达；并且(iv)在培养物中形成球形、自由浮动菌落(参见例如US2014-0235933 A1和US 2014-0310828 A1，这些专利中每一篇全文以引用方式并入)。例如在Yamamoto等人(“Derivation of rat embryonicstem cells and generation of protease-activated receptor-2 knockout rats,”Transgenic Res.21:743-755,2012(“大鼠胚胎干细胞的来源和蛋白酶活化受体-2敲除小鼠的产生”，《转基因研究》，第21卷，第743-755页，2012年))以及Kwamata和Ochiya(“Generation of genetically modified rats from embryonic stem cells,”Proc.Natl.Acad.Sci.USA 107(32):14223-14228,2010(“由胚胎干细胞产生经基因修饰的大鼠”，《美国科学院院刊》，第107卷，第32期，第14223-14228页，2010年)中提供了大鼠胚胎干细胞的来源和所靶向修饰的其它示例。
也可使用核移植技术生成非人动物。简而言之，用于核移植的方法包括以下步骤：(1)将卵母细胞去核；(2)分离供体细胞或核，以与去核卵母细胞混合；(3)将所述细胞或核插入到所述去核卵母细胞中，以形成重建细胞；(4)将所述重建细胞植入到动物的子宫中，以形成胚胎；以及(5)允许所述胚胎发育。在此类方法中，一般从处死的动物体内取出卵母细胞，但也可从活动物的输卵管和/或卵巢中分离卵母细胞。卵母细胞可在去核之前在本领域普通技术人员已知的多种培养基中成熟。卵母细胞的去核可以本领域普通技术人员所熟知的多种方式进行。通常在融合之前在透明带下显微注射供体细胞来将供体细胞或核插入到去核卵母细胞中以形成重建细胞。融合可通过跨接触/融合平面施加直流电脉冲(电融合)、通过将细胞暴露于促进融合的化学品如聚乙二醇或者借助灭活病毒如仙台病毒来诱导。重建细胞通常在核供体和受体卵母细胞融合之前、期间和/或之后通过电和/或非电方式激活。激活方法包括电脉冲、化学诱导冲击、精子穿透、增加卵母细胞中二价阳离子水平以及减少卵母细胞中细胞蛋白磷酸化(如借助激酶抑制剂)。激活的重建细胞或胚胎通常在本领域普通技术人员所熟知的培养基中培养，然后移植到动物的子宫中。参见例如US20080092249、WO/1999/005266A2、US20040177390、WO/2008/017234A1和美国专利7,612,250，这些专利中的每一篇均以引用的方式并入本文。
提供了用于制备在其种系中包含一个或多个如本文所述的遗传修饰的非人动物的其它方法，所述方法包括：(a)采用本文所述的各种方法在原核细胞中修饰非人动物的所靶向基因组DR6基因座；(b)选择在所靶向基因组基因座处包含基因修饰的经修饰的原核细胞；(c)从经修饰的原核细胞的基因组分离经基因修饰的靶向载体；(d)将经基因修饰的靶向载体引入到非人动物的多能细胞中，以生成在所靶向DR6基因组基因座处包含插入核酸的经基因修饰的多能细胞；(e)选择经基因修饰的多能细胞；(f)将经基因修饰的多能细胞引入到处于桑椹胚前期的非人动物宿主胚胎中；以及(g)将包含经基因修饰的多能细胞的宿主胚胎植入代孕母体中，以产生来源于经基因修饰的多能细胞的F0代。在此类方法中，所述靶向载体可包括大靶向载体。所述非人动物可为非人哺乳动物、啮齿动物、小鼠、大鼠、仓鼠、猴、农业哺乳动物或家养哺乳动物。所述多能细胞可为人ES细胞、非人ES细胞、啮齿动物ES细胞、小鼠ES细胞、大鼠ES细胞、仓鼠ES细胞、猴ES细胞、农业哺乳动物ES细胞或家养哺乳动物ES细胞。在其它实施方案中，所述多能细胞为非人类细胞、哺乳动物细胞、人类细胞、非人类哺乳动物细胞、人类多能细胞、人类ES细胞、人类成体干细胞、发育受限的人类祖细胞、人类iPS细胞、人类细胞、啮齿动物细胞、大鼠细胞、小鼠细胞、仓鼠细胞。在一个实施方案中，所靶向基因修饰导致DR6的功能丧失。
在另外的方法中，分离步骤(c)还包括(c1)使经遗传修饰的靶向载体(即，经遗传修饰的LTVEC)线性化。在另外的实施方案中，引入步骤(d)还包括(d1)将核酸酶试剂引入到多能细胞中以利于同源重组。在一个实施方案中，通过将如本文所述的选择性试剂施加到原核细胞或多能细胞来执行选择步骤(b)和/或(e)。在一个实施方案中，经由如本文所述的等位基因修饰(MOA)测定法执行选择步骤(b)和/或(e)。
在一些实施方案中，本文所述的靶基因组基因座的各种基因修饰可使用来源于细菌人工染色体(BAC)DNA的LTVEC，采用基因工程技术，通过一系列同源重组反应(BHR)在细菌细胞中实施(参见例如美国专利6,586,251和Valenzuela,D.M.et al.(2003),Nature Biotechnology21(6):652-659(Valenzuela,D.M.等人，2003年，《自然生物技术》，第21卷，第6期，第652-659页)，该文献全文以引用的方式并入本文)。
在一些实施方案中，包含如本文所述的各种基因修饰的DR6靶向多能和/或全能细胞用作插入供体细胞，并经由方法引入到来自对应生物体的桑椹胚前期胚胎如8细胞期小鼠胚胎中(参见例如，US7,576,259、US 7,659,442、US 7,294,754和US2008-0078000 A1，所有这些专利全文以引用的方式并入本文)。孵育包含经基因修饰的多能和/或全能细胞的非人动物胚胎直至胚泡期，随后将其植入代孕母体中以产生F0代。在一些实施方案中，将包含如本文所述的各种基因修饰的所靶向哺乳动物ES细胞引入到胚泡期胚胎中。可经由如本文所述的等位基因修饰(MOA)测定法鉴定具有经基因修饰的基因组基因座(即DR6基因座)的非人动物。使来源于经基因修饰的多能和/或全能细胞的所得F0代非人动物与野生型非人动物杂交，从而得到F1代后代。在用特异性引物和/或探针进行基因分型之后，使对经基因修饰的基因组基因座杂合的F1非人动物相互杂交，从而产生对经基因修饰的基因组基因座纯合的F2代非人动物后代。
在一个实施方案中，提供了一种用于产生在至少一个DR6基因座中包含基因修饰的非人动物的方法。这种方法包括：(a)用包含侧接有5’和3’同源臂的插入核酸的靶向构建体接触多能细胞；其中靶向构建体经历与细胞的基因组中DR6基因座的同源重组以形成经修饰的多能细胞；(b)将经修饰的多能细胞引入宿主胚胎中；以及(c)在代孕母体中孕育宿主胚胎，其中代孕母体产生包含经修饰的DR6基因座的子代，其中所述基因修饰导致至少一个DR6的功能丧失。
IV.细胞
本文所述的各种方法在细胞中采用用于修饰DR6基因座的基因组基因座靶向系统。此类细胞包括：原核细胞，诸如细菌细胞，包括大肠杆菌；或者真核细胞，诸如酵母、昆虫、两栖动物、植物，或哺乳动物细胞，包括但不限于小鼠细胞、大鼠细胞、仓鼠细胞、兔细胞、猪细胞、牛细胞、鹿细胞、绵羊细胞、山羊细胞、鸡细胞、猫细胞、狗细胞、白鼬细胞、灵长类动物(例如，狨猴、恒河猴)细胞等，以及来自家养哺乳动物的细胞或来自农业哺乳动物的细胞。一些细胞为非人细胞，特别是非人哺乳动物细胞。在一些实施方案中，对于不易获得合适的可基因修饰的多能细胞的那些哺乳动物，采用其它方法使体细胞重新编程为多能细胞，例如经由向体细胞中引入多能诱导性因子的组合来使其重新编程，所述多能诱导性因子包括但不限于Oct3/4、Sox2、KLF4、Myc、Nanog、LIN28和Glis1。在这类方法中，细胞也可为哺乳动物细胞、人类细胞、非人类哺乳动物细胞、非人类细胞、来自啮齿动物(大鼠、小鼠、仓鼠)的细胞、成纤维细胞或任何其它宿主细胞。在其它实施方案中，细胞为多能细胞、诱导的多能干(iPS)细胞、非人类胚胎干(ES)细胞。这类细胞包括多能细胞，其包括例如，诱导的多能干(iPS)细胞、人类iPS细胞、小鼠胚胎干(ES)细胞、大鼠胚胎干(ES)细胞、人类胚胎干(ES)细胞或发育受限的人类祖细胞、啮齿动物胚胎干(ES)细胞、小鼠胚胎干(ES)细胞或大鼠胚胎干(ES)细胞。
V.动物模型
本文还提供了一种鉴定用于治疗、预防和/或抑制ALS的候选试剂的方法。在一个具体实施方案中，通过向出生时表型正常但在8周龄之后患上ALS样症状的具有DR6功能丧失的动物施用试剂，在体内确定物质的抑制作用。
可例如通过全身注射、长期泵送接触或直接脑内注射，将试剂施用给动物以通过任何便利途径进行测试。这些动物可包括在行为研究中，以便确定相比于不接受试剂的合适对照动物，物质对这些动物行为(如运动行为)的影响。也可对动物脊髓、肌肉和/或脑组织执行活组织检查或解剖学检验，并且/或者可收集血液或CSF样品。
虽然已参照多个实施方案具体示出和描述了本发明，但本领域的技术人员应当理解，在不脱离本发明精神和范围的情况下可对本文所公开的各种实施方案进行形式和细节上的更改，并且本文所公开的各种实施方案不旨在对权利要求书的范围构成限制。
实施例
下面提供的实施例仅用于进行示意性的说明，并不旨在限制本发明的范围。
实施例1：DR6(Tnfrs21)基因座的基因修饰
如此前所述，采用了方法，该方法允许在小鼠中快速且高通量地产生定制基因突变(Valenzuela,D.M.,et al.(2003b),Nat Biotechnol21:652-659(Valenzuela,D.M.等人，2003年b，《自然生物技术》，第21卷，第652-659页))。简言之，使用来自小鼠bMQ(129S7/SvEv Brd-Hprt b-m2)或RP23 BAC文库的BAC克隆生成大靶向载体(LTVEC)(Adams,D.J.,et al.(2005),Genomics 86:753-758(Adams,D.J.等人，2005年，《基因组学》，第86卷，第753-758页))。lacZ/neor报告基因/选择盒(图1)与用于NIH KOMP(序列可通过因特网在万维网(www)URL“www.velocigene.com/komp/detail/10020”上获得)的ZEN-Ub1盒相同，不同的是lacZ部分中β-半乳糖苷酶编码序列的氨基末端经过修饰以包含来自ROR1的跨膜结构域。
用多孔电穿孔装置(美国马萨诸塞州波士顿的哈佛仪器公司(HarvardApparatus,Boston,MA))在电穿孔缓冲液(密理博公司(Millipore))中将LTVEC引入C57BL/6NTac ES细胞(0.125mL体积中3.3×106个细胞、0.67μg DNA)(Poueymirou et al.(2007)(Poueymirou等人，2007年)；Valenzuela et al.(2003a)(Valenzuela等人，2003年a))，然后在15cm凝胶化板上培养。电穿孔48小时之后加入包含G418的选择培养基，此后每日更换。电穿孔10天之后挑出耐药菌落，用胰蛋白酶处理并在凝胶化96孔板中培养至少三天，然后进行DNA提取和纯化。通过等位基因修饰(MOA)测定法鉴定正确靶向的ES细胞克隆(Frendewey et al.(2010),Methods in enzymology 476:295-307(Frendewey等人，2010年，《酶学方法》，第476卷，第295-307页)；Valenzuela et al.(2003a),Nat.Biotechnol.21:652-659(Valenzuela等人，2003年a，《自然生物技术》，第21卷，第652-659页)。
采用方法(Dechiara,T.M.,(2009),Methods Mol Biol530:311-324(Dechiara,T.M.，2009年，《分子生物学方法》，第530卷，第311-324页)；Poueymirou etal.(2007),Nat.Biotechnol.25:91-99(Poueymirou等人，2007年，《自然生物技术》，第25卷，第91-99页))，在该方法中，所靶向ES细胞被注射到未压实的8细胞期SwissWebster胚胎中，以产生携带DR6敲除突变的完全ES细胞衍生的F0代小鼠。雄性直接用于lacZ表达分析，或与C57BL/129雌性交配以产生用于lacZ分析的胚胎或成体，或产生F1繁殖体，并对N2F1小鼠进行表型研究。通过指定鉴定阴道栓的早晨为第0.5天(E0.5)来进行定时交配。
实施例2：包含DR6基因座中突变的动物的表型分析
对N2F1小鼠的表型研究开始于6-8周龄。对于定时交配，指定鉴定阴道栓的早晨为胚胎第0.5天(E0.5)。从出生起观察DR6KO和同窝野生型小鼠的各种发育重要事件(发育不全、呼吸、面部和肢体异常、皮肤颜色、姿势、翻正和睁眼)，直至约6-8周龄，这时将它们圈养在69-74F和40-60％湿度下、每日光照12h以进行研究。所有实验开始于6-9周龄，并且所有动物程序均按照由Regeneron制药机构动物护理和使用委员会(RegeneronPharmaceuticals Institutional Animal Care and Use Committee)批准的规程进行。
使用转杆测试、旷场运动测试和猫步测试进行运动损伤分析。在猫步测试中，受试者在照亮的玻璃台上行走，同时摄像机从下面记录。报告每只动物的步态相关参数，诸如跨步模式、个体爪摆动速度、姿态持续时间和压力。该测试用于对小鼠的转基因品系进行分型并评估新型化学实体对运动性能的影响。CatWalk XT是用于定量评估大鼠和小鼠的脚步和步态的系统。其用于在几乎任何类型的中枢神经、外周神经、肌或骨肌异常实验模型中评估啮齿动物的运动能力。
上运动神经元损伤表现为痉挛状态(即僵直状态)、反射增强、震颤、运动迟缓和巴宾斯基征。下运动神经元损伤表现为肌无力、消瘦、抱握、脚卷曲和拖曳，以及肌束震颤。延髓损伤表现为吞咽困难、口齿不清和舌颤。表2提供了有关测试期间动物的运动损伤、震颤和僵直的评分方法。使用盲法主观评分测定进行总体运动功能评估，所有数据均报告为平均值+/-SEM。
表2
0 1 2 3
运动损伤 无表型 抱握 抱握+脚趾拖曳/卷曲 麻痹
震颤 无 轻微 中等 严重
僵直 无 轻微 中等 严重
数据表明，相比于其野生对应小鼠，DR6-/-小鼠的不动性未增强，但在大约14周龄时表现出ALS样神经学表型(例如，直立活动较少表明后肢麻痹)，虽然早在9周龄时就观察到转杆和体重方面的时间差异(各自随时间推移而稳定下降(图4至图7))。但是，DR6-/-小鼠的运动神经元损失在约14周龄时达到临床症状阈值，此时运动损伤、僵直和震颤得分开始反映麻痹和/或严重疾病进展，这并不取决于动物的性别(图2)。有症状的DR6-/-动物体重有所减轻且运动异常显著，这表明上运动神经元和下运动神经元均有损伤(图3)，这些动物在约21周龄时死亡。
实施例3：包含DR6基因座中突变的动物的解剖分析
先用50mL盐水溶液、然后用50mL在pH 6.5的乙酸盐缓冲液中的4％多聚甲醛(PFA)溶液和50mL在pH 9.5硼酸盐缓冲液中的4％PFA溶液灌注约20周龄的八只野生型小鼠和八只DR6敲除小鼠。在对动物进行灌注之后，收集小鼠的脑和脊髓，并将其置于在硼酸盐缓冲液中的15％蔗糖溶液、然后30％蔗糖溶液中，直至其下沉。然后，将组织包埋在OCT中并使用2-甲基丁烷冷冻。
切开冷冻组织，装在载玻片上，并用苏木精和伊红(H&E)以及罗克沙尔坚牢蓝进行免疫组化染色。对每个脊髓随机选择四块H&E染色玻片，以计算每个脊髓中运动神经元的数目。
代表性玻片示于图9中。每块野生小鼠脊髓玻片上运动神经元的平均数目为约18，而敲除小鼠的平均数目为约2，其中p值小于0.0001(图9)。这表明，相比于野生对应小鼠，有症状的DR6敲除小鼠脊髓中运动神经元大量丢失。此外，敲除小鼠的脊髓具有海绵状病变，该病变类似于克雅氏病患者的人脑病变，这表明这些动物可能具有阮病毒样运动神经元疾病表型。
实施例4：由包含DR6基因座中突变的动物表达神经元蛋白
从约20周龄的10只野生型小鼠和7只DR6敲除小鼠的脑和脊髓中收集总mRNA。然后用在这些mRNA样品上执行RT-PCR。然后通过在样品中表达β肌动蛋白使髓磷脂结合蛋白(MBP)、神经生长因子受体(NGFR)、胆碱乙酰转移酶(Chat)、Mnx同源异型框、谷氨酸[NMDA]受体亚单位3B(Grin3b)和谷氨酸受体2(Gria2)基因的平均mRNA水平标准化。
图10至图12示出了DR6敲除小鼠的脊髓而非脑中MBP、Mnx和Grin3b的表达有所降低，进一步证实有症状的DR6敲除小鼠脊髓中运动神经元的损失。Ngfr、Chat和Gri2a的表达不受影响。
实施例5：包含內源DR6基因座中突变的动物的基因表达模式
用从10周龄野生型小鼠(n＝5只雄性)、症状前10周龄DR6-/-小鼠(n＝5只雄性)、20周龄野生型小鼠(n＝6只雄性和3只雌性)和有症状的20周龄DR6-/-小鼠(n＝6只雄性和3只雌性)的脑和脊髓组织提取的RNA进行基因表达谱分析。
来自10周龄和20周龄的DR6-/-小鼠的大脑和脊髓具有大量的基因表达重叠，并共有类似的基因表达特征(数据未示出)。经鉴定，10周龄DR6-/-小鼠的脑和脊髓中七十三种重要基因可能与发病机理和疾病进展相关。10周龄DR6-/-小鼠脊髓的基因标签与人ALS和鼠科动物SOD1生物表达数据集(数据未示出)高度相关，进一步确定DR6-/-小鼠作为ALS小鼠模型。10周龄DR6-/-小鼠的脑和脊髓具有免疫应答相关基因表达特征，这表明疾病过程涉及炎性通路。
实施例6：DR6-/-动物表现出外周免疫细胞内稳态
从10周龄和20周龄的野生型和DR-/-小鼠中分离血液、骨髓、胸腺和脾组织，以便通过流式细胞检测分析，使用抗CD3、B220、CD21和CD2的抗体(所有均购自美国加利福尼亚州圣何塞的BD生物科学事业部(BD Biosciences San Jose,CA)或美国加利福尼亚州圣地亚哥的eBioscience公司(eBioscience San Diego,CA))进行表型分析。另外，使用用于同时定量测定基本FGF、GM--CSF、IFN-γ、IL-1α、IL-1β、IL-2、IL-4、IL-5、IL-6、IL-10、IL-13、IL-12(p40/p70)、IL-17、IP-10、KC、MCP-1、MIG、MIP-1α、TNF-α和VEGF的Luminex小鼠细胞因子磁性20-Plex面板(Luminex Mouse Cytokine Magnetic 20-Plex Panel)评估了从20周龄野生型和DR6-/-小鼠中分离的血浆中细胞因子和趋化因子的浓度。
10周龄和20周龄的DR6-/-小鼠均未在外周免疫细胞内稳态方面显示出稳健效果(图13至图14)。DR6-/-小鼠表现出骨髓中B细胞发育正常和早期祖细胞内稳态，胸腺中B细胞增加2倍，脾过渡1B细胞增多且脾边缘区B细胞减少，外周中性粒细胞减少且外周淋巴细胞增多(图13)。在骨髓中，DR6-/-小鼠表现出巨核细胞/红细胞祖细胞增加14％，髓系祖细胞减少20％，但总细胞数目未显著改变(图14)。虽然DR6-/-动物表现出胸腺中正常的T细胞发育和分化，但脾普通/成熟树突细胞增加了20％，巨噬细胞和嗜曙红细胞增加了25％，脾中性粒细胞和单核细胞增加了75％，并且CD4+T细胞减少了19％。但是，脾中总细胞数目未显著改变(数据未示出)。此外，相比于野生型动物，20周龄DR6-/-小鼠的血浆中细胞因子和趋化因子的水平未发生改变(图15)。这些数据表明，DR6-/-小鼠在疾病进展期间未经历总体炎性反应，表明基因表达谱分析所观察到的炎性反应可能为局部神经炎症。
实施例7：DR6+/-小鼠中胚胎干细胞衍生的运动神经元显示氧化应激反应增加。
从野生型(DR6+/+)或杂合DR6+/-动物分离内细胞团胚胎干细胞，然后在胚胎干细胞培养基(ESM；DMEM+15％胎牛血清+青霉素/链霉素+谷氨酰胺+非必需氨基酸+核苷+β-巯基乙醇+丙酮酸钠+LIF)中培养2天，以使得拟胚体(EB)形成。将EB在分化培养基(DM：高级DMEM/F12+神经基础培养基+10％敲除血清+青霉素/链霉素+谷氨酰胺+β-巯基乙醇)中培养两天，并在DM、视黄酸和smo激动剂中另外培养5天，以得到运动神经元。在胚胎干细胞衍生的运动神经元培养基(ESMN；神经基础培养基+2％马血清+B27+谷氨酰胺+青霉素/链霉素+β-巯基乙醇+10ng/ml GDNF、BDNF、CNTF)中接种分离的运动神经元并使其成熟，以建立稳定的运动神经元品系。在第7天确定运动神经元计数，并在稳定的运动神经元品系建立1天和7天之后测量氧化应激反应。
数据表明，DR6+/-动物与野生型动物产生相同数目的运动神经元，但氧化应激反应相比于野生型动物有所增加(图16)。
实施例8：DR6+/-和DR6+/+动物的表型比较。
使用如实施例2中所述的测试比较对照动物和对如实施例1中所述的DR6基因修饰为杂合或纯合的小鼠的运动功能。神经系统得分比较示于图17A，体重增加比较示于图17B，转杆测试比较示于图17C，旷场测量提供于图17D至图17K，猫步测量示于图17L至图17Z。
在动物体重增加方面(图17B)、在转杆测试期间(图17C)、在旷场测试中测量的直立活动和直立时间方面(图17D至图17E)以及在猫步测试期间步长和后肢摆动速度方面(图17L至图17N)观察到DR6突变的显著“剂量依赖”型效应。
虽然在盲法主观评分测定中评估总体运动功能时，杂合小鼠在神经系统方面看起来类似于野生型动物(图17A)，但杂合小鼠的神经系统得分在21周龄时才开始趋向于纯合小鼠(图17A)的神经系统得分。若干其它测量遵循相同模式，由此在约20周龄之后杂合小鼠的表型趋向于纯合小鼠的表型(参见例如图17F至图17K、图17O)。
该数据表明，DR6突变在对突变杂合的小鼠中是单倍剂量不足的(haploinsufficient)。该数据也表明，随着杂合DR6+/-小鼠变老，小鼠开始表现出运动和/或神经系统缺陷，这类似于在那些测量中起初看起来正常的纯合DR6-/-小鼠(参见例如图17O至图17P、图17R)。
实施例9：DR6+/-和DR6+/+动物的感知缺陷
通过将动物置于保持在48℃、52℃或55℃的金属表面(加利福尼亚州伍德兰希尔斯的IITC公司(IITC,Woodland Hills,CA))，在动物20周龄时测试对照动物和对DR6基因修饰为杂合或纯合的小鼠的热伤害感受。测量了对热刺激作出反应的延迟时间，其被定义为在动物舔舐摇动的后爪以前所经过的时间。小鼠留在板上，直至它们进行下列两种疼痛反应行为之一：舔舐后爪或摇动后爪。
如图18所示，DR6+/-和DR6+/+动物均具有感知缺陷。在DR6+/-动物中观察到的感知缺陷可能是准确的，因为这些小鼠在20周龄时没有表现出明显的运动功能紊乱症状(参见实施例8)。但是，应当指出，DR6-/-小鼠反应延迟可能是由所观察到的运动缺陷症状引起。
本文所公开的啮齿动物提供了更近似地遵循人类ALS进展的新动物模型。不希望受理论的束缚，若干种可能性之一是啮齿动物在发育期间可能无法表现出正常修剪，如此，啮齿动物发育中连接活动增加并具有轻微兴奋过度，这可导致随时间累积的低水平兴奋性中毒。值得注意的是，虽然成年DR6敲除动物在发育过程中可能表现出血脑屏障(BBB)渗透性增加且BBB标记物发育受损，但本文所述小鼠的ALS样表型不可能是DR6在大脑血管发育中起作用导致的结果，因为血脑屏障缺陷通常表现为认知损伤而非运动损伤。
序列表
<110> 瑞泽恩制药公司
B·伊基兹
M·拉克鲁瓦-福拉丽什
S·D·克罗尔
<120> 非人动物表现出上运动神经元功能和下运动神经元功能以及感知减弱
<130> T0041US01
<150> 62/133,909
<151> 2015-03-16
<150> 62/250,229
<151> 2015-11-03
<160> 17
<170> SIPOSequenceListing 1.0
<210> 1
<211> 58987
<212> DNA
<213> 人工()
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<223> 合成
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actagtaatc ccactgaaca ttacacacgt tctttggtca aattaagcaa gcttaatttt 3180
ctgttagaca gggatagctc cctaaatcag actttgataa tatagcatga cacttaagag 3240
aaagtggggc ttgtagagcc tccaaaacct gcaagcctgg gggtttttta aggcttggga 3300
gacttccaga ggaattttga ttgcatagga acttggctag cagaacatct tatcttatca 3360
gggtgcattc aaggtgtgag tcaggctcca gagggtgggg agcaagtcgg attccagaaa 3420
cacacagtga gtgtttggtg aggaaaaagc acagtcaacc tgaattttgc agcagacaga 3480
aatgaacttc tgaccttata acaaaatggc ttccgtcctt aagatggcgt caggctggtc 3540
catcagtaac tacacccctg aagaaaagtt atttcctctc cctaactgtc accaattgcc 3600
agcaacttct cagctaggaa tagagcctca tgatttcctc tcccactcat actgggtgtt 3660
gactggcttg agtgccatgc cacgtcctga agacagcatt tcacagcatt tgtccctatc 3720
ctctggctcc tacggttctt ttgttccctc tgctgagatg taggtacccc gagccttgta 3780
gtagaagtga caggcatgtc ccatttatgg atgactactc aatggtcaca tactctcaga 3840
actgtggcca gttatgagtc tgtgttgact gctgcctact gcaaaaggag tcttctctgg 3900
gcaaaacagt agtaatctac atgtataaaa cacaaatgct tacaaggtag tttgatgggg 3960
gggggggact gtcaaacaac ccttgcacag gggtcaccta ataccatctg cacaggggat 4020
atttgtgcct tccctcagcc ttgagtaggc taaacaaacc catgatagtt ttacaaccta 4080
gctggagtct tctgacctca ccacatttgc aatttcctat agagctttga ggagtagact 4140
gcccactgag cttgctttgc aacataatct ggctgaaacg aaggatgggg tttgtgggct 4200
ttctcagtgc tgaaaattaa ctttgagcct tgatcagaaa cgtttgtctt tgcttcatcc 4260
ttctcttgca cccagttttt ttctcagttc caggcccccc cccgccccgc ccctttcagg 4320
tatacccagt ttgtccatgg ccactggaca gctacagata tttacattac gattcacaac 4380
agtagcaaaa ttagttatgg agtagcattg aaatagtttt atggttgggc atcaccataa 4440
cacgaggaac tgtcttaaag ggtcacagct ttaggaaggc tgagaaccac tgtcctgcag 4500
cctagctctc atgggtcctt gataaggttt gtagcaccag acatgaactt tttcctgtgg 4560
agcagccctc aaagacagtc agaaagagca gttggttatc ccaacaacca acatgtcact 4620
attatatcaa gggggctttc ctatagcgtg aatggtcctc agagggtaag tccatctttt 4680
ctccccacgt cgcagggata gcatttcctg gcaccatgaa agcaggccag tagaaaggaa 4740
gtttctaagg accttgtact tctgatcctc ctcctcgcat gtgttgggat tacaggcctg 4800
caccaccaca tccagtttat taggggctag gcatgtgcac agtaagccaa cactcaataa 4860
gcagaacgac actcagacct cagccccttc atttagtgtt agtgtgttgg tggttgttta 4920
ttattattat tattattatt aattcaccac acagcaattt atgtcctaca tgtcacattc 4980
atttttaaat tccctttact ttttccccta ctttgtttta gaatatatgt atatgtgtat 5040
gtgtatacac gcacacacac acatacatat atatgtgtat acacacatac atatatgtgt 5100
attcatgcat atacatatgt gaatatacac acatacacac gtatatatga gtatacacac 5160
atatacatat ataatatgtg cgcacacata tattttatat attagcattc cagcttaggg 5220
gcttcagtgt agctcattgg cacagctctt gtctagcgtt ccagttttat ttctactttt 5280
ggcttttaag tctatttgtt ctattgattt aaagcttaca gtacctcggt gggggcacac 5340
acctttaatc ctagcactct ggaggcaaag gcaggtggat ctccgagttt gaggccatcc 5400
tggtctacag atcgagttcc aggataaacc gaaagtagag aaaccatgtc tcagaaacca 5460
aaagctaaaa caaacagaaa agattcacaa caaatatttt taaatcatta caatatatta 5520
caatatcatt aatattacac ccctttaagg gtagtataag aatctttatg ttatgtgtct 5580
ataaaatggg ttgaggagct ggtgagatgg ttcagtggat gaaggagctt gttagcaagc 5640
ctgccaactt gagttcaatc cctaggaccc acgtgataaa aggagggagt agattctttg 5700
aagttgtcct ctgacctcca catgtatact atgtcacatg tgttcggcat aaaataaaca 5760
aaaacataga agggagccta ggagacagtg ccgttggtac aaagcctgct gcaagagcat 5820
gaagccctga gtttgagccc tagcactcgg tcttatgcat acagcacatg tctgtaatct 5880
cagcactggg gagacaaaag agtgagtggc cctggagttt gctgggctgc cagtcaagcc 5940
aaatcgacta gctccagata gggagtgggg cagagaaaga ctgagcccat ctcaatggtg 6000
ggcaatgatt gataaagaca tccagtcttg ccttctggct tcccataagt gcatccctca 6060
gtgatatact gttacctgga agagtaagcc aaccaagccc tttcctccct aactgatttt 6120
ggttggaaag gaggccattt ccatgaagct aggaattgac cttggatgga agatgctggc 6180
ggaagtttct ggtttagtcc aggtggcccc cgaagtgtgg gctacaccat ttcccagaaa 6240
cctctagtag gcatgcactc cagctaccca tgctggacac tcgttctttg atctctctcg 6300
tttactttct tattttcctt atattatttg ctcgtttatc cccagacatt cctgggactg 6360
tcttttacac aaattcttca catcccatga tgtctttccg gctctccgtc ttggaagaaa 6420
acacccaagt gactgactgt gaccaaacgg ttacatgcaa atgtatgaaa tctggggacg 6480
aatgcagtaa taaaaggtga cttaaagggg ctggagtgat ggttcagtgg ataagagcac 6540
tgactgcact tccagaggtc ctgagttcaa ttcccagcaa ccacatggtt cacaaccatc 6600
tataatggga cccgatgccc tcttgtggtg tttctgagga tagcaacagt gtactcatat 6660
aaataaatca atcttaaaag aaaataaaaa acatttcatt aaactcgata ataggtataa 6720
atgcgaactt aatggatgtt ctcagggaag ttgactgtaa cttgtaattt gttcagtgaa 6780
tagcaagcat ataacaacca gacggctaaa actaccacac cgctaccaca catgtttctt 6840
tacgtatcac atctgcattt ccccttgcct caagcatagt acttggaact ttgttcctca 6900
tattttatga ctgccttcat ttttttagaa aagagttgtt actattatta tatgtaagta 6960
cactgtagct gtctttagac acaccagaag agggcatcat gtggttgctg ggatttgaac 7020
tcaggatctc cagaagagca gtcagtgctc ttaactgctg agccattttt ctagctcaag 7080
tgcctttgtt ctttttctgg agtttctgga tctagacagt gtgccttaat tttgttcttc 7140
agtgatgttt ccagcctgca accgagcttc ccttcctcgg ctggaaaccc atctttgcct 7200
tctagattcc tgaagaggtt gaatttcatg tgctgactac aggtcccttc ttcaaaaccc 7260
attctgccct cagaatctat gaacccgatt taaaaaaaaa aaggattttt atttttatgg 7320
gtttggctat tttgcctgta ttcatatctg tgcaccacat gcatgaagtg cttgcagagg 7380
ccaaaagagg gcgccagata tcccggaact ggagttacag atggttgtgg gccagtgctc 7440
tggaaaaaca gtcagtgctt ttaaccccta agctatctca ccagccctca tcttctctta 7500
gaccgagtgc tagggctcaa actcagggct tcatgctctt gcagcaggct ttgtaccaac 7560
ggcactgtct cctaggctcc cttctatgtt tttgtttatt ttatgccgaa cacatgtgac 7620
atagtataca tgtggaggtc agaggtcaac ttcaaagaat ctactccctc cttttatcac 7680
gtgggtccta gggattgaga agtcatctgt gatttttgac ccagctgccc tacctcattt 7740
tgcagggaac agggatgggg atgggaatgg caaagggcag gacactgttc caccttccgc 7800
ctcaaggctg ttaacaaggt ggtttaatac tgaattgcca gcccagccca gcccagcctt 7860
tcactatttt cccggtattg tcaaacattt cctccacact acctatagaa tattcttact 7920
tatgtttaat gatctacttt agtgtttatt ttaagtacat actatgttcc gttccttgac 7980
ctcgctgtac tttgtttatt cgtaaatata cttacccacc tgttgtaata aaaatgtcct 8040
tctgtccttc cttcctttct tcctttcttc ctttcttcct tccttccttc cttccttcct 8100
tccttccttc cttccttcct tccttctttt ctcccttcct tctttcctcc cctccttcct 8160
tctttcctcc cttctttctt tcctcccttc cctccctcat ttctttaacg ttcaaccaat 8220
gtttctttct cacgtttcct ttccaaggtc agttccgagg gctggacaac cacactaagc 8280
tcagcggctc cgcacatcct gccctcgtgg agcccatgtt aaagagaggt tggtggagac 8340
acgcaatgga cactggagac aacgacttag cttagtaccc taaaagtgaa tggaggatat 8400
gcaaaaataa gatagagggg agagcaaagg aatttggcgt ccagcgttag tgtgtgtgta 8460
ggagtgcgta gtaaagagca gaagctcgtt acgtgtgcag cggatgtgag agtctcacag 8520
agggaacccc cagcgctaag ttcctgaggc ttggtgggtc aaagaacaaa ttaacctcag 8580
catagttacc cttccataag caacaaattc tccaggtcca ctaagcctcg tgatcagcag 8640
cctgtacagt cacttatgag gaacttttat agggagaaca ggatgtgatg gtgtatttaa 8700
acatatgtat ttaaagatgg ctcagtgaat aagggtgctt gttgcccaga cctgagttca 8760
atccttgggc tccacgtggg ggaaggagag aaccaactcc tgatcctcca catgaatgct 8820
gacatgagca tgcacataag caatacatga gtctaatttt aaaaaaggaa aaatacctct 8880
ggttaacata taataaattg ctattctttt agatggttgg attcctaata cacaccagca 8940
cagagtgaac gcactgggta atgtacaata gcaaggtgac ttacatcaaa ctacattaaa 9000
tgtttaaaac agtgaaaacc tgaaaagcta acatttttgt ccaatgtgaa aaaaaagtct 9060
tatttagtag catgatatac acagaggtaa aaatagatat cagaaagtcc cccacatatg 9120
ctaatcaatt ttgttcttaa tctttacata tccacttatt tttgtgatat ctttatttta 9180
tgcataaggg tgttttgcct gaatgtatgc ctttgtaaat acttgcatgc agtacccaca 9240
aaggccagaa gagggcgtga gatcccctgg aattgaagct actgatggtt gtgaaccacc 9300
acgttggtgt tggaaatctg acccaaatgc tctgcaagag tcgccagtgc tctgaaccat 9360
gtccaagtta tctctccagc attatatatc cacgtttgaa gtagaggtac attgggcttt 9420
tcatttttat agtggttact taaagcatag tctatgctgt ttttaagtga cagaatgttg 9480
ttcattgtat ttaaaaaata tagacaaaaa tttaaacact ttaaaaaata ttatttttct 9540
ttatgaagat acatgctttt aaggggttct gttggagaat ttcagtagcg ccaacttaaa 9600
acaaatactt tattagggct gtagaaatga cttagaggtt aatagtgtgc actgctcttg 9660
cagaggatcc gagtttggtc cctagcaccc atgtcagggg cttacaacac aacctcctgt 9720
aactgatgct gcaggggatc ccaccccctc ttctggcccc tctcatgcac aacacacatg 9780
aggcaggcac agactgatgc acatatatgt gaattaaacc ccaaataaaa tcgttttcaa 9840
aagtccaatg aatgtcttga caatgctttt ataatcaatt cattcatgac aggtggttcc 9900
ctgtgtttgt gatttctctt caagctgcgc atcaaagcaa cccctccttc tccctccttc 9960
cctccctcct cctcctcctc ttcctcgttc tcctccctct ctctgtgcat gtgtgcctgc 10020
ttacctgttt gcgcaccgca ggcgtgcagg tgcccacgga gtgattaatg aattctttgg 10080
aactgggtta caggcagttg tgggcgatgt agtgtaaatg ctgggaacca aactcgggtc 10140
ccttggaaga gcagcagtgc tcttcacaga tgagccatcc ctcaagtccc caagaacttg 10200
tttctcttgc tcagcttgca ctctccaaga cttaggaaag tgcttagtga ataagctggg 10260
gcacaaaaga tgcggttata agaaggtgac gtaggagcct ctggcaagcg atgcagatgc 10320
caattctcac ttgtgttccg gtccctctcg cttttgtcag ttttagaatg ttctaggctg 10380
ggtttggtgc tgtcgtagca cagagaggaa acagcatgaa ggacaaccag gccagagata 10440
gttgatggtc tgagcctttt gtttgctggc ttcactcgct ccgctgttct aaagcttcag 10500
tcaatgggtc tatgttgaac cagtttccgc tgttcactac aaagatgcaa ttggaagccg 10560
agggagggag ggagaagctc tggagagtat ggctcagtgg ttaagagcac tgactgctct 10620
tccaaaggtc ctgagttcaa atcccagcag ccacatggtg gctcacaacc atctgtcatg 10680
ggatctgact ccctctgaag acagctacag tgtacttaga tataataata aataaatctt 10740
agaaaacaag tagctgaggg aggagttttt tacttgtctc atccagggtg cctggaggat 10800
gacggcgagg cgccactttg cttacctcac caagtgagag ggacaaaaca tagttttgat 10860
ctgcagtagc ttcgcggtga gcaccacatc tccacctagt cctccgctat tgtcggctgc 10920
tatgaacaga ccctgctgtc acctggccat ttatctccat ggtcctgttt aagctctagc 10980
ctattgacta aggggatgca agttgaagtg gatgtcccca cgtttgaaca cagcactaca 11040
tgctggtatc tgaaatctga gtcacatcta ggtcagtcac attttctaga tttatgagtc 11100
tagattttat ttttccaggt gtcttgtttt tctgtctcta aatgatgaca tccacccccc 11160
tgccttcccc ccccccccca cacaccatat accctgggta tggttatttg tagcaaaatc 11220
aatactcttg tacttgaata atttttttct ttgcattttg aaccaaggtg tttattcaca 11280
aaaggaagaa ttgtccattt gtctgtctgc tcagtctttg gcttagcata gggcatgtgc 11340
agaggctcaa taaaaatctt ttgcctcaat cagtacatgg cacatgcatt acctcagggt 11400
catatttgta aataggtatg ggtgtttgcc tacaggtgtc tgtgcaccac ttgcatgcag 11460
gtgcctgagg aggccagtag agggcatcag atctctggga actggagtta cagatggctg 11520
tgagtcacca tatgggtatt gagtacaaga gagactctgg aagagcagac agtgctctta 11580
gccactgagt catcactgta gcccgcatgc catattatta aggaggctga acaccaagtg 11640
attcagcctc gctacagaca agtagaaacc tgtctctggc ctccttaacc acaaagttgg 11700
ggggcttccc tcgacacaga agccagagaa ccatttgaca ccgttcctct gtcacaggct 11760
gtatcattgg tccattttcc acatgacact gtgcattcaa gcattcatct ctgcagatcc 11820
ctgggcagta tggcagtgtg tgtgtgtgtg tgtgtttgtg tgtgtgtgtg tgcttgtgtg 11880
tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtttgtg tttgtgtgtg tgttctaatt 11940
ggaaaggaaa tcttcacttg cctttaaagt gcagtgctac tatatttctt tgcaaatata 12000
tatacgtata tgcatatgta tatgcagatg tatacacaca cacacacaca cacacacaca 12060
cacacacata tctcaaagtt cctttcaggc tgaagaatcc attattgtcg ggccagtgag 12120
atgacagagc agtttaaggt atctgctgcc aagtctgatg acctgagctc aatccctgaa 12180
atccacaccg tggaagggga aaactgtctc ccacgagttg ttttcttgac cgccacaggt 12240
gtatgcaaat atgcatgtgc acgtgcacac aagcactaaa taaacagaaa gtttaaaaaa 12300
ttaaggtata tattatttac tatgtaagag aacatcaaaa aagtcttgag aagtacacca 12360
tgggagaaaa cacacctagc ccttcaaata atttgccctt ctagaaaaat cctgaaatag 12420
ccctttcccc atacagtagt agaatgataa cattatctca gagatgagca ggcgtttaag 12480
gctcagcgga acgggaagag agttgggttt ttcttcctat ttgttttgaa tagctctgct 12540
cccgggtcct ctgcttgccc agatgatctg tgaaatgggt gagtgagcag cgcacctccc 12600
cagcgcgact gttactgacg tcagcaagcc tcattagctg ctgtttgtct aaccaaaggg 12660
aacagcgggt ggagagaatc ttaatgacct gacttcccac actgcaggtg ccacttgcct 12720
ggtgtgcacg ctgagattgc atcagctgac taggcaaaca aggaacagtg gaaatgggag 12780
gcagagaaaa agcccaagag agactgccca gtgagtggaa ctcgctgctc catcctggga 12840
gagtgtagca gagatgtttg tgcgtggtgg agtgaggtcg actcaggttc acagctgtgc 12900
gctgctacat agtagttgag ggtcgaatca cttaaaggct ttagtcccgt tttcaaaatt 12960
aaaataggga taatgataga accttaggga gaaggaggga cacgtgtgta aatcacagac 13020
ctcattgtac cactggataa ctggcaggag ccactgtttc tgactctaca gtggagagaa 13080
gggaagagca atgattggca ctgtggacgc aggtggcaga gaacagctaa agatgacttt 13140
atatcctaaa ggcaagtggg gtagctgtga gttttaaaga ccgaaccttg cttcacaaaa 13200
ttgctcttgc tttcctacct accaattctg cgttctttct ttttccctgg cagcatctcc 13260
ccggcggact cagccttggc tacagcggag actcctggga aggaaatgtc cttccccagc 13320
cctaggcaca gtggttattg tctgttctca catcctgtga gccctgtagg cagaggaatg 13380
ccccagaacc acagcaactg tgcaaacatt tgaattccca cgggtagttt cccatcctcg 13440
tacccatgag gcttctgctc tctgtagtca gaagaacgta cacagttctc aggagcagga 13500
agtagagggc taggaatcat gggtgaggag cctagcatgt gtgtgaatac atccgtggaa 13560
aacgtttttg agggagatag tacagaatcc tactccaggt gaaataatga gactcttgct 13620
aagaccacgt acggatgacc caatcaatac acaaggaggg agttgaaaag gagaaaaggg 13680
gttggccatt aatttagcca acgtataatt ccacgtatta gcaagtaact ttaattatcc 13740
tatgcgccct cggttttatt ctccacagct gtaaatggta ataatacccc ctttgaacat 13800
ttatcatgat taattaaggc agtgttgttg aaacatattg aaagttacct aggctaactt 13860
tgtccaattt gccagctgct ttggcaaatc ctctgcactg gggctggctc aggctagaac 13920
tatcttccat ctgggtaaat ctcttctcca ttccagagca gatatcatgg cgggtagctt 13980
gacctcacag tcatgagaca actcaaacca tggggattgg caaatgaagc aagtccttgt 14040
tattgaactc tccactcaga aaaaataaaa aataaaaaca tattaatact acggaggatt 14100
ccagtgacac tcccttctgg gaaagacact caagagattt ttatgagcag tcagggcaga 14160
tggaagtcac aaggcaaaca cctcaaagta aaaaaaaaaa aaaaaaagat caacatacca 14220
gagcactcaa caagctgaca gtctggctgc ccatgctaga tgcttagaat acatgaatga 14280
caaagtttgt atgcagtctc tgcctttagg gactttactg ctaatggggg attgtttatc 14340
aaacctaaat aatatccttg agggaatatt actatactgt gggtattagt gttcttaacc 14400
aatatgggtg ttgactttgt ctgtgtctct ctctgtgtgt gtacaacgtt tgggagtcaa 14460
ttctgtcttt ccaccacatg ggtcctggct atcaaactca gtctctcagc attactggaa 14520
gatgcctttg ccccatgagt catcttgaca gcaaaattgg gtattgagaa cttgaaagtt 14580
tgctgtgtga agaataagta aaacatgcta aaaaaaaaat aaagtagaca ggctgcacag 14640
atggctcagc agttaagagc actggctgtt cttccagagg acccaggttc atttcccagc 14700
acctacatgg cagctcacaa ctgtctgcaa cttctgttcc aggggatcca actccttcac 14760
acatgcaggc aaaaacacca atgtacatac aataaaaata aataagttat ataaaaatag 14820
gcaatctcat agttttacca tgttaattat atgttaaact agcaatgtgc atatattgca 14880
ttaaataaaa atgattcctt aactaaatta atttctttaa ttaaataaaa tgcaaaaaaa 14940
tgaatgaaat aaaatcactt tcacaaggtg gagaaacact ttgggaagac atccagatgt 15000
gaacctcagg cctccacata cacaaacatt aataagtatg ttaattaaaa ttaatttcac 15060
tttactttta aaaatagaac tactagattg tttaggatag aatatataac ttctgcccaa 15120
tatttgctca tattcttttg gaaaatatgt gttcaaatcc tttgcttatt cttaaattag 15180
attgcttgct tttattgttg tatttttttc tatcccaaat agccaaatag tatatttgtt 15240
tggaggtgta tgtggctgtt ttaagacagg atttcttttt ctttttcttt tttttttttt 15300
tagctctggt tatcctggaa ctcactctat agggcagatt ggcctcaaat tcacagagat 15360
ctgcttgctt ctgcctcctg catgctaggg ttaaaggatt gcactggtgc tgggcatgac 15420
aacccccccc cccctttttt tttaaccttc actggtatag tacaaatatg gcacacagac 15480
cattcaccca tacacataag agaaggacta aacaaatatg tttaaacatt aaaaaaaaaa 15540
aaactattgg aaacggaatc gtcaaactgg aatggtggag atttcatcag aactggcttt 15600
gttcattttc ctgtctccgt caaactgtct gctctgtcac agtctggttc tccaccacgt 15660
ggctgctgct tctgttggtt cagatccctg ctccgcagtc tgagccaatg aaatcccggc 15720
tcttcacaaa ggcggtttta gtggcaagtc tttggggctt cttctgttct cttggaagaa 15780
tggccccagc agcttcttcc atagcgcttc tggtgaacca gatggcatct tgttcaacct 15840
cttactgcac tgagcacgca gcctcccctt acaagattca taccaatgtc tcattgtttt 15900
ccaaagtaac ttgagacttg aactttccca gactctcaaa taaaaccatt ccttgtggaa 15960
gagtgcggtg gtctccagtc tttagagact gcctgcctac ctaagcttta ggggacagag 16020
tgggacaaca ctaacaaggt gtgtgggcat gacaacctct aatcttctca gctagcttca 16080
cctggaatct cagtcttatg agtaatctgg actaacagta agggactcat tatttgatgc 16140
ttgccacatc tggggtcaaa tcttggcccc tagaaatggg agatggatgg acaaagatgt 16200
cctatacctt tagctatacc ttctaagaat tcagcctcaa cagcttggag acagacggga 16260
ggacaaacag ggtgggcttc cctggttgct gggcccgctt agggcttggc tgtaggctga 16320
aagggaaggg agcttgctct ctcggccaca cactgtactt gcatctccat cgctgggatg 16380
cagacagtga agagaacaga ccgtagctct gcttgttctg agacatagga aagcgctcca 16440
acaaatgttt cttcacctat cgtatgctct gaggacaatt tccacagact ctagatgatc 16500
atcgttgcac aatttttagg aatcttcgca gtttccttga agtgtgtcct caagagttcc 16560
tgatgctgcc gttatagaag tgggagtagt tgggggtttt atagacaaac tctaaaacta 16620
aaagaaggag atatacacag ttacagaagt gtttggtcag caaggagtca aaaaattagc 16680
cagtgcacac taggcagcat attaaagtat ataatatagt atatattata tactatatat 16740
attataaagt aatgtattac aaagtaatat attactatat attataaagt aatatactat 16800
aattaatata taagtaatat actataacac atataatata taacaaatat aacatataac 16860
atgatatatt atattatatt atagtatagt atagtatagt atatataata agatactact 16920
ggctactaat ccatccaaat ctagaatgaa ccctgtgtaa acacacagga aaacagtggg 16980
aaatctagta gaaaactgga caataggtat taataggaaa ttcacagaag gcaaaacttt 17040
tcaaaatgac aagttcatga atggggcttt atcactatta aatcctttaa aatgcattta 17100
aatgccaagg cgatggctca gctgttaaag agcttgtggg gggatcagga ggaccagaga 17160
ttggatccta gtatctgggc caatgtcaga aggatgtggc agcctgccta taatgctagc 17220
tttggaaggt ggagtcaggg tatccccaga acaagctggc tcgtgggatt agccacattg 17280
gtaagctctg ggtttaattg atagagcctg aatcaatgaa gggaggagag agtgacacaa 17340
agagactcct gatgtcaacc tcaggactct cttcatgtat gtggacacat gtgcatgcac 17400
ccacacacac gtgtgtccac atatttgaaa acagatattt acatacaata cacacacaca 17460
cacacacaca cacacacaca cacacacatt caaagtaagt aagtgcataa aaatggttac 17520
attgtagcag tttgtatatg cttggcccaa gggaagtggc actattagga ggtgtggcct 17580
tgttggagga agtgcatcac tgtgggggtg ggctttgagg ttcttttttc cattttctct 17640
atttgatttg attactacag ccatgaaatt atgatgatct acatatacag attttatgac 17700
aagaaaagaa aaattcataa aaattttgaa gctggagcag tgattctgtt ggtaagatgc 17760
ttgtaagctc tgggctcata tccacttatc agtgagtgca tatcatgtgt gtccttttgt 17820
gattgggtta cctcactcag gatgatgcct tccaggtcca tccatttgcc taagaaattt 17880
cataaattca ttatttttaa tggctgagta gtactccatt gtgtaaatgt accatatttt 17940
ctgtatccat tcctctgttg aaggctttga ggttctatgt ttaagctcta ctaagtgcag 18000
aagaaagctc tcctggttac ctttggatca aaatgtagac ctctcagctc cttctctagt 18060
accatgtctg cctgcatgcc gccatgcttc ctgccatgat gataatggac tgaacctctg 18120
aacctgtaag ccagtctcaa tgaaatgttg tccttcataa gagttgcctt ggtcatggag 18180
tctcttcaca gcagtaaaac ccaacaaata tcactaagca atttttaaaa ataaagctaa 18240
gggctagtga gacggcttgg cggttaggaa tgcccgctgc caagcctgaa gacttgatga 18300
gtttagtttc cagaatttat atggtggaag gagagaacaa actcttagaa ctgtcttctg 18360
accttaacac acactgtgtg ctacactcac gcctacacaa atgcatgccc acgtaaacaa 18420
atagatgcga aagtcaatgt aaatacaatt ttttaaaaaa aaatgaataa catgcagtta 18480
agatgaggtc atattatact ctcaccattg gacaaaactt atatgttatt gtcctcattt 18540
ggttctgttg ctgggataaa atgcagacca gaactaacct gtggatgaag gggttcattc 18600
tgtttatagt ttatcctcct tcactgaggg aaggaaaggt ctacatcacc cagaggaaga 18660
actgaatgaa gcaaagacca tggaggaatg atgcttactg gcttgccccc aggctcaggg 18720
tcaacgacct ttctcatgcc tcccatagcc acctgcccag ggatggccca gctcacaatg 18780
gcctgggtcc tgtcacatca atcaacaatc aagaaccttg cctcacagac atgcccacag 18840
gccatccctc aaccaagatc tctccctccc acatgactac agtttgtgtg aagttggtga 18900
aaaccagcta gcagtttatc aaatcttggt gggaaaaaga tagagagaca gaactacgct 18960
ttgaggagca acttggtggt actaagtgaa attaagtata tataattatg gctaaggaaa 19020
taacattctt gggttaatac cttagaacat cttccataaa caaactagag gaaggtaatt 19080
taaagcacaa ataggcaact aataccatct taaactaacc tacacaccta cgggttatga 19140
atggtgacca caggctctgt atgtctacta agaaataact atgtgagtca aaatgaaaga 19200
accaatcgat ctacatacgc cagcaaggac ggtttctaac tgtgcttcgg atcgtaaaga 19260
taacaaagca aaattagatg atagcatatt aaaggttatg taacatgtga atataatggt 19320
ttctgtggtt cattgttaca tccgtttatg aatgaagctg tggttggtga atggtatgca 19380
ttaggataat aagcgtgggt acctggtaag agaagagatg aaaatggctg gaggaggcag 19440
tgattacagt tccattcaga agggaatcta gagcctggga gatggcttgg taaagggctt 19500
gccaagcaag catgaggatc gaagttcaaa tccccagtcc ccgtgtaaaa agctaggcag 19560
agcaacacat gctcagagcc gaggagtcag agacaggcag atctctggag tgcactagtc 19620
agctgactca gctgagtccc tgcactccag gtttagggag acactgtctc aaacaaacaa 19680
acaaacaaac aaacaaaaca gctggaatgt atgctgactt agttttactt gacatagcta 19740
gagtcacggg agaagaggaa acccccaatt gtgaaaatgc ccccactaga ctgacccatg 19800
ggaaagcctg tagtgaattt tcttagtgac tgctgtgaga aggcccagcc cagcatgctg 19860
tgagtgggtt gtcctgggtg ctgtaagaaa gcagactgaa caagcatcgg gaggcaaaag 19920
ctgataagtt gtcccttcct gtctccaggt tccttccctg atgtccttca ctgatggagt 19980
gtatctgaga gttgtaggct gaagtcaacc ctttcctccc caagtagaca ggaggttaga 20040
aagatagccc tgtgggtcag agtgggtgcg gtacaaatag gaggatgcac cttcatatct 20100
caacctttgc atgagcatct gggtgtagac acacttatgc ctgtgacacc tccttggagg 20160
tggtgatcgt gggactgact ggccaccagc ttagtttcag gttcaataag ctaacctgtc 20220
tcagggaagt aagatgagga gtgagagagt ctggaacacc ttctctggca tttgcacgca 20280
catatggata cctctccaca tgcttataca gtacatacat acactccact ggcatgcaca 20340
cgtacacatg cacaccaaca acaaaaaagt aagttgaaaa aaattaaaga aacactccat 20400
gttaacttat ggcctttaca tgcatacata tatatgtgca cacgcacctg catacactta 20460
cacagaggga gagattacat aggcgttgtc agcagtgtgc tgcagacaaa gaggtatgat 20520
cagtctttct gagatgaatc ttagtgatga ggattccatg atgtatgagc aacagggctg 20580
ggcagtgcag ccagctggtg ctgcatctcc tttcagtttg gattatctta ttgggtcaca 20640
ccagaaccag ggagataaat agtcaagaca gactttgaaa attcatacac cacacacaca 20700
cacacacaca cacacacaca cacacacaca cacacaccaa taaagctagg tttgaatgaa 20760
ttacttttgt aaaatccagg tctgagttgt attctgaaag ctttacttgt ttggactggc 20820
cagtagctca gtcaggcaaa aagacaccac acgggagggc agactttaaa gaagaacgtt 20880
tcaatgaggc aagctgtcac ggcttgtgtg aattacacaa tgaaagggaa aataaaataa 20940
aactatggcg ggctaaaatc tgtaagttct gacatgtggt cctcgtggca ccatctgctc 21000
atgaaagcat gaagaggctt ctggaacttt ccaggactgg gttgatttgt ctccacaaag 21060
ctgcctgggt aagaccctgt ggcactgggt catcaagaag gtactagcag acttcctttt 21120
tatctcagta tttttctacg tcagtcccca aaccatgaaa caacagggct taccctgcca 21180
caccaaaggt caaactatgt tttctcttac ccaactattg cctgggatgg ctccaacttt 21240
attactaccc cacctccaac ccgtaataac tctccagctc tcacttcaaa tccaagagag 21300
tgtggactga gtgaggggac cagagacagg tgcatctggt agaaagttat actcaattaa 21360
ctaactgaat gcatttgcat gtggttttaa ttccactgtg cagcaatttc ctgagtaaaa 21420
atggagagat tatatctagt ttttgagtca ctgtaagaat taagtaaacg tagctctcaa 21480
tctatatctg cacattattt ttcctcgtgg tcctagattt ctcttgttcc tgaccatttg 21540
tcccgtcttg gaatttcccc agccttcaga ggtgtagccc tataatttac cgtccagatt 21600
gcaatccctc ttcatggcat gaattaagtc ttatctcacc aggaagtgct ctttcctttc 21660
ttctgactcc tctccctctg gctttcctct tcatttcttc tctacactgt ttagggaaag 21720
aggtttctta gcaaatcctc agacacccca actagtgggc ttcccggaaa gtctcagccg 21780
tgtgtgggag gtctgccctg aagaagttct ttgccagaaa atgaagcaag gtgttctggc 21840
tggacagtga gggtggtaga ctgtaataag tatgtctggc tttaactctt ctatattcat 21900
ctgaggggag catctgagcc caacacaaca tctccatcgt caatggagaa tcctactcag 21960
ctgacaaggc ccttgcttct gtgttgaagg attacagcaa tggcctcctg tttattgacc 22020
tcatacttag acccatgagg catgcatatc atagtttatt tctcctactt agcaactgaa 22080
aatactaaag ggagtcacag agtctgactg ctctcacggt ctgtatctat tgcttaatcg 22140
aaagcttccc tgttaccctc ccatagcaaa taagggtcca tcccacaaga cactgtggaa 22200
acgcctcctc tcaagctcct ccagacctcg cagtgagtca atagagagca gaggggtctt 22260
acgtctctgg tgcctaaaga ggatggggtg ggcgttaggt ctcagcaaga acatctcttc 22320
ttatgtggcc agcggagagc ccagaaatct taagcttttt cataagggtt tctttgagac 22380
gcttcctaac ctagtgatcc ggttatcacc aagctaaggg aaaacgatca cgtgacacga 22440
aggatgaagg aaaaccctca gattcctcct cctctgaatc tgggagtgga aaactgagga 22500
gctgagctca gagttccaga gccacgcgaa gctgggctca gcagtgtttg cagctgcagg 22560
tctggtgagc ctgtggaaag agagaagggt gagagaagag agtctccaaa aagctgcccg 22620
aattagagaa acaagagacc ctgcctcaaa aaggcagaca cctcaagtgg tcctctgact 22680
tctgttcatg tgtcatgaca cgagcatccc tgaatccaca tacacagctg agaagcgtgt 22740
acacacacac acacacacac acacacacac acacacacag agagagagag agagagagag 22800
agagagacag agacagagac agagagacag agagacagac aaagagacaa agagacaaag 22860
agagagaaac agagagtggc tgaagggagg gggcagggga aggagggagg gggaggggga 22920
gagacaaata atttataaaa ggaaaatcat ttaaaacatt tcagggctgc cgagatgacg 22980
cagttgcaag caggaagccc tgagtttgga gccccagaac gcatccaaaa gccaggtgtg 23040
gagcgtgtgt gttctgtatc tcagctctgg aaacaagggc ctcgccatct attgccaatg 23100
ggctgccaaa ccaacaagga gcgagcaagc cccacttttc acgtaaaata cctcaaagag 23160
aaaagcaaca gatgcaaagg ggagagaatc tcgcttttgc ccagatcatg tagcagcccc 23220
gctcttagag gacgtactcc atgtctatgt gacttcaact ttcaattcta caaaaagggt 23280
tggtttcatc cctctcttct caatctggaa acagttcgtt ttaacgacag atgggtgata 23340
ttacacttag aatcaaactg ttaagccatg tgaatgaatt tatggtcacg tcatttcgaa 23400
gcgtcccctc tacaaccccc ctccccccgc tgggaaaaga ggggcttccc gctttcccag 23460
gaagggaagc tgtgggctct gctgggggac acacactgag ggactttcat cagcatccct 23520
cccaagaggg aagggacatg tctgtgggcc ttatggtctt caaagggacg taaagccgtt 23580
gcattctgat tagtttgtgg agggtacttg tttcaatcca gctacagttt ggtttgtgca 23640
gctggtatct gctgagcagc tgccgggacc tgtgtactct cgaaatcggt gaggctaacc 23700
cctgagaagc agagggtcgg gtgtcacgag agacttttct ttcccttttt ggcagccata 23760
ttgaaagatt cacagacacg ctcttaactt atccatgcaa agtgagactc tgctcacatt 23820
ccctgatact ttccttcaaa atgcaccagg aaatgtcagg aaataattca attagtctca 23880
ggaaatttac aaactgtgca aaacgttttg aatccacttt tagaacactt tcaatgacca 23940
caaaagctga agaaagggca gaaagaggca agggaaagag gaaaggaaga aaggaaacaa 24000
acaagcaaac aaatccagtt tgtcttcaga aggattatgt tggaggttcg ttttgcttgt 24060
agagactagt tcatctattc caggcttgct ttgaattccc tgtataatgg agacaggccc 24120
tcaacttctg gtccttcggc ttctgtgtgg cattacagtt gagtgctatc acacttaatt 24180
atgtcagagg cgtttttgtt tgtttgtttg tgtttatgtt ttactttagc agtggctgga 24240
gttggggtgg ggttgggtta ctccagcagc tcccaagagg atcagccttt caggctgtcg 24300
ctggaagggc agctatatag atgctgcaag aaaagcaact agctcctgct cttagagaac 24360
ttttgtttat tattattatt aatttacttt atttacattt aaaatgttag cccctttcct 24420
ggtttcccct tcgaagaccc cctatgccct ctcccctccc cctgatcacc aacccaccca 24480
cacctgcttc ctggccctgg cattccccta cactggggcg ctgagccttc actggaacaa 24540
gggcctctcc tcccattgat gactgactag accatcctct gctacatatg cagctggagc 24600
catgagtccc accatgtgta ctctttggtt ggtgatttag tccctgtctg ggggtactgg 24660
ttagctcata ttgtttttcc tcctatgggg ctgcaaatct cttcagctcc ttgggtactt 24720
tctctagctg cttcattggg gaccctgtgc tcagcccaat ggtaggcttc gaggaaccac 24780
ctctgtattt gtcaggcact ggtggagcat ctcaggagac agctatataa ggctcctgtc 24840
agtaaggtct tgtactcagc tattaaaaag aatacattta tgaaattctt aagcaaatgg 24900
atgaaactag aaaatattat cttgagtgag gtaacccaac cacaaaagaa cacacaaata 24960
cgtggtatgc actcactgat aagtggatat taggccagaa gcttggaata cccaagatac 25020
cattcacaaa ccacatgaaa ctcaagaaga aggaagacca aagtgtggat tctttgatcc 25080
ttagaagggg gaacaaaata cccatgaaag gagttacaga gacaacgtgt ggaacagata 25140
ctgaaggaat gaccatccag agactgcccc acctggggat ccatcccata tacagtcacc 25200
aaacccagac acttttgtgg atgccaacaa gtgcttatgg aaccttttat ctatagagaa 25260
ggtttctcag ctttggtagc attaattaat tcgttgtcat ggaaaggtgc cgtttacagg 25320
catcccttcg cctctccctg tagttgccag aaacatctta gatatggatc aatatcttct 25380
ggggccagga gatattccca aattgagaac cattggtcag cactctgtct atcatgactg 25440
caaacaaatt gaaaacttga caaacattaa tgaaaacttg ataaacatta atgaaaagaa 25500
actcagaaaa cactttgata gtattttctt taagacatgc catgcgtggt ggcgcatgcc 25560
tttaatccca gcactcggga ggcagaggca ggcggatttc tgagtttgag gccagcctgg 25620
tctacagagt gagttccagg acagccagag ctacacagag aaaccctgtc tcaaaaaaaa 25680
aaaaaaaaaa agacagggtc tcatgaaacc cagactggcc ttgaactcac tatgtagctg 25740
tactgcctgg gtttgtgtgt caacttgaca caagctggag ttatcacaga gaaaggtgcc 25800
ttccttgagg aaatgcctcc atgagatcta gctgtaaggc atttttttca attagtgatc 25860
aagggtggga gggcccattg tgggtggtgc tggactaacc tgggctggta gtcctggatt 25920
ctgtaagaaa gcaagttgag caagccaggg gaagcaagcc agtaagtaac acccctccat 25980
ggcctctgca tcagctcctg cttcctgacc tgcttgagtt ccagtcctga cttcctttgg 26040
tgatcaacag cagtatggaa gtgtaagctg aataaacccc ttcctcccca atttgcttct 26100
tggttatgat gtttgtgcag gaatagataa cctgactaag acagtagcca acgatgatgc 26160
tgagcctctg attctcctgc ctctaccttc tgagtactgg atttacataa gtgagctgtc 26220
acaccagttt atatggtgct ggaatcaaac cacaaaggct cccagcatgc aaggcaagca 26280
ttctctcaac tgagctacag cctcagtttt agcaatgcaa agaagaggaa aaggagggag 26340
aagatatata tatttttcat tacatatatc tcacatatat tttacattac aaatatctca 26400
catatatttt aaagcgctgt agtggtgaga tattgggctt tgtagacacc aggcattctg 26460
ctgtcctggt tcttcaggct ttatgatctt gaacaccata gttctatttg gtgagtctgt 26520
tttctcagga gttgttgact atgcctttag tccagtgcta tctgaagaat gaagatagta 26580
tctctctcag tacacctttg gcaagggaag ataccatctg cccagtatca tcatgtacat 26640
tggttgagag ttaactctgt gctaagtgtt gtggtaaatg cattatttct tattccatcc 26700
tcatggcaat cctaccaaat gtcaaaaatt attatccaca atttgtagat aagaaaacca 26760
aaactttgac acattaaatg actgtcttag gattttgttg ctgggaagag acaccatgac 26820
caaccaaggc aactgttaca aagggtaaac atttaattgt ttctctgagc acttctgtct 26880
tccaggattc taccacaatg gcctttctgc tctatttaca gtattcaact gtttttttag 26940
tacaaagttc caaggtcgtc cacagtcctg caaaaagcaa cacaatcagg tacttcccag 27000
caacggcgat tcttgagtat cgatttctgt attatttaat cttctgttgc tgtgataaaa 27060
tgccacgact aaggcaattt acagcagtaa gagtttattt gggcttacat ttgcagaggg 27120
ataagcgtct ctcatggtag ggagattgga aggcagtgag tggggcctga cagctggaat 27180
aggaagcaga gtgatcacat cctttactgt gaacaggaag cagagacagc aaacagaaaa 27240
tgggctcaag ctaagaaaag aactctcaag tccagccgcc agggatgcgc ttccttcagc 27300
aaagatgcta gctctccaac agcatccacc atctggggaa ccaagtgttc aaacacacgg 27360
gtctgtgagg aatatgcttg accttaacaa agctagggaa atgtgtagac tcctctacac 27420
agctggaaga tgttcactct ctcttctttc ctttaaacag tttcttaaaa attatataac 27480
ccactcatat tttcctaggt gttacaatca taccttacct ttaatcacat tttcatttat 27540
ttgtttgttt gagattttat gtttaattat gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 27600
gtgtgtctgt gactttgtgc acatgaatgt ggtgcccatg ggagccacaa gaaggcatca 27660
gatcatttgg agctgggaaa gcagagccgg aggcagggac atctggcaga gttcagagtg 27720
gacatgacta gactgagctg ggtcatgtgg ggagatgtgc agaggaaggg aaaggggaga 27780
gatgggaaca aggtgcggca ggcaagagag caaagataca cacacacaca cacacacaca 27840
cacacacaca cacaccacat atgtacatat acacatacac acatgcacgc acgcacacac 27900
acacatattt agatgcattg aaatcatttg atatacaaat agaccatgca aagatcaagt 27960
cagtgtgatg gacatttcca gctgtttaaa ctttttaata cttgttagta ttgagagtcc 28020
cacccccacc ccatttcact gctttacaaa gatacaaaac attgttctgg gcatgttggg 28080
tgcattcctt aatcctagtg atgcagaggc aggcagatct cggtaagttg aaggctatcc 28140
tggtctatac agtgcattcc acgctagcta gggctaccag tgagattgtt tcaaaaaaca 28200
aaagtctgta gttatcttcc tatattgttt attcttctct gccttcctct ttttctgcac 28260
acctgtcttc tctgacactg gtcagcatgt gtgagtgctt gggcccgtta atttgtgtga 28320
gcagacatgt gtcaacatca cttagaggaa aggtggcaga ctcattaaca cacacgatta 28380
acatgattag gaccagtttg aaagcagcag ttctccatct tcctaattca ggcctgactg 28440
tgtcaggact ctacactctc tacactgttt tctcagctaa cttgtccttc ctgtctctca 28500
cctcttcccc acactgacac acatgtatac acagcccccc caccacatac ctaccccccc 28560
cctacaccac agacttccag agagagggag gtggtgacta cgctgtatgt gtttaactgt 28620
tacctgtctc tccttagttc tgaatgaaat ggaatctaat cttaatcctt tcctgtcatt 28680
attagattca tggagtccta acggccagag tctctagatc ctgtcttatg aaattcaact 28740
ctcatacaaa attcaaagta tcagtttcag agaaagttat ttgaaaaaaa aaactgtgga 28800
gttgaaagca attgaggctt attctggtcc tcttactcag tgtgtgtgtg tgtgtgtttc 28860
tgtgtatgaa tgcatgtatg catggggtat acatgcatgt atgcatgtgt gttcatgttt 28920
ggtgtatgca tgtgtgtatg tgtgaggtat gtgtatgttt gtgaggtgtg tgtattgtgt 28980
gcatatgtga gcacatgtgt gtgtgtgtgt gtgtgtgtgt gtgtatgcat tcagagacag 29040
agtgtgctca gcttccagta gatcctcagc taggaggtgg tatcttgtga gactcttccc 29100
tctgcatgct gaactgttga ccggcttgac ctgtgaaggt cttgtgcagg caaccacagc 29160
tgctgagagt tcatgcatgc aatagtcttc atgtttattg tagttctccc taactctggt 29220
tcttaccatt tttctttcta gtctgtgatg ttctctggat cttgcaggac aggccataat 29280
gcagataccg agttttattg atgtcaatgg tccactgggc tagcagcctt actgactctg 29340
ggatagatgc tgttaaatca atgacagtgg ctttttaagt tacatccaga cgttaggcag 29400
gaatagataa ctcagatata acacgaaggc ttacccctgt gtttttgatt ttaaaaaatt 29460
gtgagtgtgt tatacgcagg catggttatg cacattgatt tgtgtggttg tgggatctta 29520
tgtcagaggg acttagatgt cttcctttat tactaccgat gttattcttt tgggacagga 29580
acctggactt catttctttt tgccaggaag tcagaaagcc ccagggatcc tcccatctct 29640
tccttcttaa tttctgggct tctgtaggca tgagcaaaac tatgcctggc ttgttaggtc 29700
ggcactggta tctgaacctt tgcttccatg gttgtacagc aagtgttctt aactcatgag 29760
gtcccgattt ttttgtttta cttaatgcta tgttgtactg tattatatta tgttttgctc 29820
tctctctctc tctctctctc tctctctctc tctctatata tatatatata tatatatata 29880
gactggcttg caccatggag tatgtgtcag tcaggagata ccttttggaa gacagtgcct 29940
ttaaaccatt gaaccatttt tctgcccatc acaaattctt tggactaaaa aataagagtt 30000
tctttttcct taacaggaca aaactttatt ctctgatatt taaaatataa gagaatattt 30060
caaaatttca aaaaccagtc ccttaagtta aatcaagtgc ctgctccttc acatctctct 30120
tctcttttga tgtaagcact tattgatcta aactcacttc ttgaaaactc ggagcatctc 30180
acaggcttcg ctatgttgcc tctctacttc catttgcctc aagataattt ttaatttctc 30240
ttttaactat ttcattagcc tattgattat tgaggaccat gtcaaatttc ctaggttttg 30300
tgcccccctc ctcaccggag actttgaaag aatgtatgtg ctgcaaatga caacttagtt 30360
tcttgaagtt tattaatttc tttatgcata tgtatatttt gcatttattt tcactgtttt 30420
gctcaatgtt tgtcattgtt ctagtttcct ttctgttgat aaaacactct gaaaagcaac 30480
tttgaagaga aaaggacttg tttagtttgc tcttccaggt cacagtccat tactgagaga 30540
agtcaaggta agaactctag gcaggatgcg ggagccgtga gggagtgttg tttgctggct 30600
gactctctgg aatgttcaaa ctagttttat tatatagttt gagcctgcta gtctagggat 30660
ggtgctgccc acagtgggct gggtcctccc acatcaatca atcatgacat tttctatgag 30720
acacggccac aggacaatat gatcaaagag atctctcaat tgaaaactga aaaaacttcc 30780
tcttcaggtg aatctacgtt gtgtcaaggt gacaacttgt ccagtagtac taagcagggc 30840
agtcatcttt aatcagagag atgacagtat atattccctt actgtatggg tttgtgttga 30900
gacacctata atggcagaca gattaagtct tcctgcatct gctcagagcc cctgtccaaa 30960
cagttccttc ttccctcttg tctctccttc ttcagacagc ctacacaatt cataagcagg 31020
agaaaacatc cataggatgt tttccagtta gtgttctaga atttcagtag tagaaaggat 31080
ataaaaatta cttagaaaca gggagtactc aatggcaaag tgcttgcctg gcatgcatga 31140
agccttgggt ttatcacccc cccccccact cttagtccat atttatcatc tttcatttaa 31200
ggaagcttaa aataccagag gactagagag atggcttatt ggtaaagagc acttgttgct 31260
cctgcagagg accagggttt ggtttccagc acccacaagg tggctcacaa ccatcagtaa 31320
ctctagtcca ggatgtttga catctttttc tggcctctgt gggtactagg cgcacacata 31380
gggcatatac atacatgcag gccaaacaca aaagtaaaaa taaaaaatat tgtctaaaag 31440
ctatctcaga cacagggaag tgcagagatt tatcctaaac cacactgttg gttaatgtga 31500
aagtcaagct aagataaata aataaataag taaattaatt aattaattaa taagtaatag 31560
agggttggag agatggctca gctatttagg gtgcctgcag ctaggatgca tgttttgttt 31620
ccaggggatt gggggcatga gagaaacctt acaacctgct acagggaatt ggacatgctc 31680
tcatggcctg tgaggatact tatacacaga agacattctc tctctctctc tctctctctc 31740
tctcactctc tctctctttc tctttctctt tctctttctc tttctctttc tctttctctt 31800
tctctttctc tttctctttc tctgagacaa acacacacac acacacacac acacacacac 31860
acacacaaat aaaaacaaat cttggcttat ctgtgcatcc tttaatttca tcactaggaa 31920
ggaagacaga tctttacaag ttcagggtca gcctgatcta caaatcatgt tttagatcaa 31980
caaaggttat gttatgagac cctatcctgt ctcagagaaa caaaacaaac aataacaacc 32040
gctcccccac tcttatggta aaatgaaaag ttactaaagg taggacaccc aagagcacac 32100
gggacgagga tttctaggca agcatctttg tgcagtgttg cacctattat tgaccagcat 32160
tgtttcagga aatgttaggc agaatcaccc cgctgttctc ggaagcaaaa cagaggtgtc 32220
acaccttctg attagactgg ccagcttgct tttcaaatca tctcttcttt atcatcaaag 32280
agagaaggaa acctcggaac aatgctgtct ctgcaatgct atccccactc gatcttatcc 32340
aaggctgccg tctttgttgc catagccacg gagacctgat gcgcaggtat ttgatcttgc 32400
tatgtgccac tgaagggtgg atattccatc ggagaccaaa gaacaggagg ttgttaagtg 32460
tgttgtaggg aatcagagcc atggagaagt tgtttgatct gagtccaggg ctgagcagga 32520
cattggtaca tcctggatga aagctttacg gtttgtacac agcttggaga agtttaagtc 32580
ttggaaaagc cgggcagatc ccatgtgtta actcctccat tgctgccagc ctttccaagc 32640
ctgtttcact taacaaatat ttattgagcg aggtcattac ctccaatttt cactacggag 32700
acttgaaaat taagacacgt actctgcctt tgaggacctt tgaggcacac agatgtaaac 32760
tggccattgg ataatatcat acatgacacg tctgagacac gtgaggggaa agtagaaaag 32820
ggtctatgtc tcatacagca aatgtataaa gttctgtagg taaagtgcca tttgacatgg 32880
ctcctaaaag tccccaaaga tagatttatt tatttattta tttatttatt tgcacatgaa 32940
taatcaactt gttgaaggac tgagagacca cagaaaaaca agcaggagga atagcgacca 33000
tccaggaaag aggcttgact gggcagaagg gtcaaactcc aggagacaga agacaatttg 33060
aattaagatt agccaatctc agagattcct tatgaatggc ttgatgataa ctcctcagtc 33120
ttagccagtg ggaagttttc taggaggaat tctgattggg cagatcttta gccacatgca 33180
atgcccgagg gtagaagatg tgtcttctta ttctgggcag ccacactgtc agctgaaaat 33240
agggtgtgtg ggttgtcatg tggacagtgg cagttcctat aatccatgcc tacctgtgct 33300
gtagctgcac tccttgactt acacacacac actctctctc tgtttctccc ttcctccccc 33360
ctctctccct cccttccctc tctccttttg cagaggtggg tattgaaccc ccgacctcgc 33420
acgttatgat agacaggcac gtatccctgg gcgctatgct gtactattaa cgatttgtat 33480
ccctttcctc tggagaggag atggcgggct tttcaaaaga aagaaagaaa tattcttact 33540
ctatctatag tacccaacag tgtctggtac acctacatac acagatatgc agggcccgtg 33600
gaaacacaac aattccactc ctgtttaggc aacttttcat gctctttttt tccctctgaa 33660
cttggcttca tacagttttt agtgttcaac cttagtcttg ttaaatccac tccaccatag 33720
ctcagcctaa tcatcggctt ttgaatggat ttacagaact agacacacat ttcctcctac 33780
agagcagacc ttacgtccca tcagaaagca gttggttaca cccaaatgtt gtatggccct 33840
ccattaaaaa agatgagctt atttgtttta tgtgtgtgag tgttttgctt gtatgtatac 33900
atgtataact tgtgcatgcc tgatgtctgt tcaggtcagg agcaggtgtt tgctggatct 33960
cctggaactg gagatataga tactatgacc tgctatgtgg gtgctgggaa tcaaatccaa 34020
gttctctgca agagcagcag gtgttctttt tttaagttaa tattttagag aatttcatac 34080
acaaatactg ttatttacct cattaccacc ccactcaacc tggatcctac ccccaaccac 34140
tcccttctaa aatttatgac ttcttcattt cttttttgag atttatttat ttattttata 34200
tgcctaggtg cttctatcta tgcacccctt acacggctga tgctcaaaga ggccagcaga 34260
gggcgccagg tcccctggaa ctggagttag agatgacggt ggcttttcct ccctttttac 34320
caggagacct agtcctcaca gaggttttca ggtcagttcc agtttgattc cttcaagtcc 34380
tgtgtccaaa gtgtgtgttg tctttagcca tacgcgttta atgtcaagtt ctgggaggca 34440
ccaaagagaa cagcagaagc cgctgggact tctctgacca acagcacgga ggtttttcat 34500
acacggtact agatagtttt tggctcttgc agggagcatt atagcccaag ctggtgtaac 34560
accatttaaa gcacacgtaa gcagtatatg catatactta cacttgtatt catttatgta 34620
ttatgcatgt gttcttttta gagatctatt ataggtgtat gaatgttttg cccacatccg 34680
tgtacatgca ggacatgtgt atctgatgcc tgagagagtt agaggagagg gcatcaggtc 34740
ccctggaact ggatttacag acagttgtga gcagccacga gagtgatgga gactgagcct 34800
gtgtcctcta caagagcagt tactgctttt aaccactcag cctcgccccg ctacgcgtgg 34860
atttttaagt aaacacgaaa taaacttttc ctttcgcctt ttcaaactca ctttgtctta 34920
tttatgcctc ttccctcttt tccctctatt ttattcttcc ccctcccatt aaagccccac 34980
ccccttttct attcccccct ccctttttgc taggacacag caagtgctct taactgagga 35040
gcagtctctc tagaaccccc gcccacgcca cacatctttt agagctgaaa atttcctaca 35100
gcttccgaaa ggaagaatca ggatagagtt tagaaatata accaacagag gagaagatgg 35160
caaaactact gctgccttca gcacagagag gctttaccta gaaaatgggg ggggaaatgg 35220
aaacatggaa aaatgcattg attggaaata taccgaggac atgggaagtt ttaagggtga 35280
tgagcttgag gcgaggaaac cagatttgta cagttttgga agaaacatgc aaagtttaaa 35340
ttcggctggg gatcagaggc agttatttta tggcaaagat gagattggtt ttgtccagct 35400
tggcctcatt tgtacctctc cattttagct atagtcacat cttattaata cttacctcac 35460
tctttggagc ttaggcagaa aatccattat ttatggttga gtattcacca tttatgtgta 35520
agtaaggaca tctgtatgcc attgaatatg tggttgtgaa gtaattaaaa cagtttacag 35580
tgtaaaatga aagacatttc tctattttaa acatgcaata gagaaatggc attttatata 35640
ttgtttagaa agatttattt atttatttaa tgtatgtggg tacacactgt agctgtacag 35700
atggttgtga gccttcatct ggttgttggg aattgaattt aggacctctg ctcgctccag 35760
ccaaccccat ttgctctggt tggccccact tgctccatcc caaagattta tctattatta 35820
taaataagta cactgtagct gtcttcagac acaccagaag agggcgtcag atctcattat 35880
ggatggttgt gagccaccat gtggttgctg ggatttgaac ttaggacctt cggatgagca 35940
gtcagtgctc ttacctgctg agtgctgagt catctcacca gcattttata ttctaactag 36000
attcaataga cacttttgtt ttgttttgtt ttgtttgttt tttgtttgtg atgaagaata 36060
ctaaggggtt tttacttagt tagcagtaag caagatgaac tgaatatatt gtatcaagag 36120
gcatcgagat tgcatggctg taactcaggt ggtgatgaag gaggataacc atcccctgga 36180
ggctaacctg agctacacag caagacccaa cccaaaagca gccagccaac caaaccaaac 36240
tcaaacccaa aggcccgtga aaaattgaat tctgatgatt agtgccccat aaggacctta 36300
tggaacatga aaacaatagg aagaacaaag agaacgagca ggtcagaacc acacttaccc 36360
aaattaaagt ctcccagctt ggaagatcaa atcatacatt acctcaagta actcatattt 36420
gtctgcaagg tgtcagctga ccccttttct ttaatatctc acttcccacc cccaccccct 36480
tttaaacaga aagacctttg attgtggtgg ccaataattt gaagttttga agaattaatt 36540
ggccctatta tacatgaaga catagtaatc ccccttcact tttggaagcc tcggagagag 36600
tttgagaatt tcaagttgaa atatcacccc ctttcacaaa attctgtatt taaggatagt 36660
atttttcaga atttaaaaaa attttttact ggaaacttaa tattacagca ttccccttca 36720
gggtttatgg tcaagctttt ttaaatatat gttttatttc tttaactggc agatgtttga 36780
aagatgagag taggattaat cctcatatta atttttaaat acatctcatt cttccaaaga 36840
atgccgagaa aaagaaccaa ctctccatgt agtaactggc aaggaaggaa atagggctcc 36900
taccatggca actccctgtc agggatgctt agtgttgttt ctgtccaggt tcctcactgc 36960
tgagaacaaa tagccaacaa tactgagaga cggggaggtt tcttctggct aacagtttca 37020
gggatacagt tattgcagga gaggagagga gaggagagga gaggagagga gaggagagga 37080
gaggagagga gaggagagga gaggagagga gaggagagga ggcagctggt taaaccgggt 37140
ctgcagtcag gaagcagggg agccacacat aaatgccgag actacacttg ctttttcctt 37200
ttgctccact gtgagaacac agcagacctc aaaacacagc agtttgggaa ccaacacaca 37260
cgtctctttg tgtctggcaa ttgatgtaag ctccatggtt tttgcttttt ttctagctcc 37320
tttaattgat tgattgattg attgattgat tgattgattt ctgagactgg attttgctct 37380
gtaagccagg cttgtgtaga actccaattt tggctggcct ggaattggag aagttcatat 37440
tctcattata cagagtgctt aatggcaccg ttatgctcag gtcattcatt cattcattca 37500
ttcattcatg catgcatgca tgcatgcatg catgagatag gagttttctg tgtagctcag 37560
aatttccctc caacttcaaa ttctccttcc tcagctttcc tggcaatgaa aatacaggcc 37620
tgcgccatta tgcgcaagtt atattggctg ttgttaatat ttatgttagg aaaagaaaat 37680
agtctctgtt ttacatacaa tctacttgga atcatttttt ttttttaaag ttaagtcggg 37740
gtgaggggtg tgtgcaggtt aacaagcaaa cgcaattcct ccagctaacg ccaaggggca 37800
ccctctcctt cccctcggtt tctggagcgc cttgagttct ttccatctgc acaaagagcc 37860
cggcctcctc ccgggtgaca tcacaaaggg tcgttctccg ccccttcggc gccaccacgt 37920
gtgtccccga gctgagtggc catccgactc agtccctcgc cggccggtct aggcagcgga 37980
ggaggcgagt gcttgatagt ggctggaagc ttcgctatgg gaagtcgctc tttagcactg 38040
tcgcggctag ccctgctctc tggttctccg cagccgctgt cgttggagag caccgggagg 38100
cgcgggttgc gagcgcgcct gcttctcacc gcccgggcgc cagcgcccct gggcaggtgc 38160
tgagcgcctt tcggagcctc ccctgctgcc tccctcttcc gcctgggtgc ctggctgctg 38220
cagtgcacat gggctgctgg aggtagatgg gctcaccgcc cgtgaggcgg cggtggatgc 38280
ggcgctgggc agaaacagcc accaattcca gctgccgtgg ggccgagcgc cccgggcgcc 38340
gctgcgagcc ccgagctcgg ccatggggac ccgggcaagc agcatcaccg ccctcgcctc 38400
ttgcagccgc accgccggcc aagtcggagc cacgatggtc gccggctctc ttctcctggt 38460
gagcgatagg aggggaccct agggtggcgg ctacgttcga gcctgtgtcc gggagccggg 38520
cgggtcctcg ggcccgtagt gccggaggcg cgcggtggga ccagacgggt tggaagggtt 38580
ggttacaagg caatagccag accgaggagg actcctacta gatcgtgtgt gtgtgtgtgt 38640
gtgtgtgtgt gtgtgtgtgt gtgtgtgtgg tgagctaagg ctagtgagtg ttaaagaatt 38700
atttttcttg caatctggct gcttgaagga ggcgcgagag gtgtccgcct cgaggtcctg 38760
cgcatttttg ggtttttgcc cccgactcgg cctatctcgc accccaacac ccagcctcac 38820
cccaatatca ttcgctgcca gaccctcggc gcggtgcgag gcccgagtag tcctgtcagt 38880
agccagctgc cggttgtggc cgctcctttg tcgctactgc aatgtcatgt ccggatgcta 38940
ccgcagtgga gacagccgga tcggtgcgct ccggacgcga gcaaccgctg catgcttccg 39000
cgcgcgaagc tttccggagt agggcgcagg ccaccccttg cttcagcttc cttgcttctc 39060
tcctccctct tagttcagat gggtcctgat ttctgcaagc caaaagaaga agaagaagaa 39120
ggagcccggg tgggtggtgg gggtggggtg ggagggggag gaggagaaga aggacccaga 39180
gacccaggcg cctctaaagc acaggcttgg agccaaccgg cgctgtggct ctcagtcgag 39240
ggggagggga aagagctaca taaaggacga ttaattttcc ccatcctttt cttatttctc 39300
cctttctgtg tttagacatg tcaccaagca agatgatgca ggctctctca gcacccaaat 39360
ctggggcgtg cccggattgc aatcctccat cactttatct gatcaaaacc tgacatcatc 39420
ccttatccaa aacttacccc cagctggccc tttatttcca atattggggc caagtgggga 39480
attaggtgga agaaaatttg aattcaaacc cttgagatgc tataaaccaa tcatgtcttt 39540
catccctgca gggaggatga aggttgttag ctaaaaacta aacaaaaaca aaaaagagct 39600
tgttttcatg gttgggctgt gtaagggaag gcaggcctct tgtctccttc ctctaaaggg 39660
cttactgcct ggccagccaa gatctactgc ttccatccca aggcatgaca gttgctatgg 39720
cctgggaatt cattctacag acattctggt tctctctgtc tctctctgtc tctctctctg 39780
gctgactctc tttctgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg 39840
tgtgtgtgtg tgtgtttagg gagagagaga gagagagaga gagagagaga gagagagaga 39900
gagagagaga gggctaaaga aagtttgttg ttcttagcat ttatgaggta aatctcagtg 39960
tcccttgaga gacgcttttc tgtcttttta taacaatggc aaagtccaag ccctttaaac 40020
aagtgtggat agtaaataat cagagagtct ttgggaccgt ggacttgaat tgacagtctt 40080
agattgaacg agttcaagga agcactgatc ctaatgacct gagttaggtc ccttgctgag 40140
ttccctccaa aggtcttaga cctgcttccg tgatgagcat atactgccgt gtgtccctgc 40200
tccacacaga tacaatcctt atacaatact tatagatcag tccactcaaa tccaatctaa 40260
agttagtgct caatgtatag tcgtaatctg gaattatttt ttaactttta gcctgatata 40320
taggtccttg aaggtctcag catagtaaaa ccatatgctt taagtaacca agaaagggcc 40380
tagttctttt tattaaatga tcaaactcaa tgtacccaca gattgcaccc agatttgcaa 40440
ctgatgacct acagtataag tttgacagtt tgatgaagtt tatgaaaggt attttagaga 40500
caatctcaag gtgacgatgc tacagggttc cttgatttcc tggtaactat ggcaaaaggg 40560
ctttctttaa attgatggag taggaggagg gtgagctgac catcctggag tgtgggaata 40620
ctccaggaaa catcaggagc tatgcaatga ccttctccat ccccactttg gacggtccag 40680
tcatcaggac gggccctgtt tctgtataca acagtgatct ggtgactctg ttctcaggag 40740
aattggtccc attggtaatc ttggccacat taacagcaga caccaggtag gacagctcaa 40800
gtaaacatgg tgtgaggtac ctagaagaat aatgggggat acaggaaggt taatgctatg 40860
tatatacagg gtggttagat aaagaaataa tgatggcttc caattgccct tctctcattt 40920
ttttttcata gcagtctttg ttgttttttg tggctctttt ttttttctat cagcatgaag 40980
agcttactat aggctctgat atgtatgcct atcatatgaa cttgtcaaaa gagcagcgag 41040
ctaatttata cagaatatgc cactatccct gtcaaacggg tgtcacctcc attctacgga 41100
tgagaaaata gtctccaaga atcttactgg tctgttgtag tatgtggtga ctctgggctg 41160
gaactccttg gctcctactc tctctcaccc acgtaccaca ctgcccgttt cacaacttca 41220
agttgtttgg tgagtgtaag gacagagaag gactgctggc aggtagctga gacggtggct 41280
tgattaattg gggaatataa gtgagacgtt cacaaggacc tttggagtga gtcagtctag 41340
ttgctggcat ttctattgct gatgtgttga tgtgaccgtg tcatgtttgg aagttactca 41400
caaactgaaa tgcagcatac acgttccagg ccaaagttct gtaaatgaga catttagatc 41460
tgtagtggtt tagggattgt cctagaagga cttgcttact gcaatgctgg atgcagtcag 41520
aggtgcctct tgcctttagg gagcttggtt tgactataca gatagactga ttgcaaggga 41580
tggtcaaggg aggaaagcaa cttccttggt aaagactttg gatttggagc tttggaaact 41640
gctgttatcc acggactgag aattcctgca ctgaaggcac agggaagaag gcatagcaga 41700
agaaggagtg gaaagattct aaaagccaga ggaacagaag ttgctgtgag atcgtgtcac 41760
ctggaaatgt ccgggaagct tcactcatga agtttcaaca gcatggctgc gtaagcggga 41820
tctgatcaga gaacaccagt ggacaggcta acacagaagg gggaacttca tagggcctca 41880
gccctagaca aaaaattaga aatatgggct actaaggaat atatatgtgt gtgtacaata 41940
cgtgcatata tatacaaaca tatgcacaca cacatatatg tatgtgaatg taacacatgt 42000
gcatatgtat tatgcacatg tgcacatatg taatagcaat tgaaaataac gccatgaatt 42060
tgagtcgtgc aaggctggta catgagaggt tggctgtcga gaggaaaggg aaggaagaaa 42120
agatttccac acaagaggtt gtccagctgt ctggccatcc cttttctagg cagctggcat 42180
ctcaccattt ctggtcacca aaagaaaaaa taccttattt atttatttat ttatttttct 42240
tttgccggtg ggaaatggtc agacacatca tcagacacat catcagacac atcatcttgc 42300
ttagagggtc ccaagtgtta ctgttggcca ctgctcctga gttctacctt ctgacttcca 42360
actatcacag aaaatggcta tctgcctggg caggagtgta catgtgaggt catctggggt 42420
ggggtggggc actcaagtcc tagccttggt gacaaatcca attagaatat gaaatcagag 42480
ctggcgggca tacagagggc tctctccctt tgatatactt taacacagca tcctagactg 42540
tggaagctgg gagggaagct aagctgttac tgatctaaca ccccacacag cttggctgag 42600
ggaaagaaca gcctccactg cggaagtgac tatttttcat tttaccaaat ctacatggtg 42660
cagaggcggg atcctaagca gtggaagccc agtgatgaag tgggattaga accttgcgtg 42720
gcatgaagct catttctgtg gcttataaaa caagtggccg gtgtcaatgg atcaatgggt 42780
gagcatgcta gaccccgaga gagacacaga tgtgatgttc acatcttcaa aatatgtagt 42840
ctgtcagagg aggaaaacac ttctattttg gaaaactttc caatcttgga atgatatatg 42900
ctagttgatt tatgggaaat tgttaatgag gaggaacaag taatccagat cttctactgg 42960
attgaacaac tcctgatttt taacccataa gttatcccca caaagtttag agtagggtca 43020
agctttctca tttggactta ctgtatatct ctggctatca gatttagtca cagacagaca 43080
gacagataga cagatagaca gagtctccag gacaactaag caattaagat gaatctacaa 43140
gaaaaacctc tgtagttaca cgggcacagg tccactgact acttatacat ctggacaatg 43200
tctaccaatt agataaagca accatagttt gccttcccca gtggtcaggg gtgggtttgg 43260
cttcagagct gggtctagtg agtagctggt gtcttctctt tggaatttgg ggacatcaca 43320
tcttgacttt tgcacttgac tccatcttga ggagaggcaa agcttcttgg gaggcttggt 43380
agaaaagctg caaattggct ctgtgctaac tcagccagca ggcaaactat aattggctta 43440
cataaagttc acgattatta ttattatttt tttttctttt ggtgacggga aacggtgaga 43500
tgcatcatca gactattcaa gggccaggac gaattgagcg acttttcctt gcgtaaacag 43560
ctctgcctat tttccagaaa gcactaatac tctgttggct tgcttccccc ctgcacaggc 43620
ctggcaaatt gcggtaatgc caggtcacca ccagcaactt cttggcaatc tcaggtgctt 43680
ctcttctgtg actagaaggg cccagattaa ctggtgggta tccggtggtc atttggagtt 43740
gagtccattt ggagcacgag atgcagatat attggatgga cagaatgaca actgaagcca 43800
ttagtaggag cagcttggcc cactgagtgt cagcaggagg ctggacttgg ttgtttctgc 43860
attagaggcc actgagttgt gttctttagg aatagaggcg agagatggtg gataaacact 43920
ggctttctcc agtgtttata tttgtcaaat acctaaaaat caacaggatc ttaaattggc 43980
ttgaaggctg ccacctggtt ggacagtgat tattaacctg gagggagact ggcagatgat 44040
cagaaatatg ggtggggcct ctgcttatgg agagaggttt tgatgaccgt gctgttgaca 44100
gaaggcagat gcgcaatcaa cattcatgaa gagtgctgaa gtcggggtcg tgtgtgtcct 44160
ggttggaggc aacatgtcta tagtgttagg aaagttgtgc tcagggggct ctcaggaagg 44220
tgtgggatgc agcaggacct cggtaagctg gcaggatgct gccccatgtc ctttgatctt 44280
ctcttcagaa tggttgcaga ctatgcatga ctcgtcgcag gtctaagaca aataaaaaga 44340
attggagaga agcacatagc caaatcagaa cacggctagt agagctatga gacaggccta 44400
tatcgtgttc cattcgctct ctgcaaccag gatcactgta gtggctctgt tgcttggcac 44460
catttgcaaa atctgcttgg agggaagagg aacacaggct taatagagtt agacaagaac 44520
atggagcttg tccatgtgcc ctggcctcaa gagagcagct gtgaaatcag cagagctcct 44580
gtgttagtgg cctttggagg aggactaagc aaatggctgc taacccttta tattgggatg 44640
ttatttaatt tatatattat aaaaatatta tgtaatatat tcattcatat actatagaaa 44700
tggttcttat tactgcattg aatatcttct gtaaagcact acagtgtaca ttttacaagt 44760
cccagacatg acagctttag tcccatttta cagaatccag aataaggttt gatagagttt 44820
ttgctcagat atctgcccat tattacgttc tggagagagg gatgaaatct agctcagcat 44880
agtttcaaac acttagctct ctctgccaag agagaatgga acaagtgaac agaatggttc 44940
acttcaactt cccatacata cgtttgttta ttctaaaggg aatggtttta cccaagaggt 45000
gaacatgccc gttttattct ctgagtttca cagtggtacc tgaatggttt gccaaaacta 45060
ctggtacttg tgagcatggt gtgtgggagc tgaaagggga gggcgtggag acattgggcg 45120
aacactttcc tatggtgtga ctctgacgag ccatggtgcc acggttgaga tggaaagaca 45180
ccccagcaaa ttgaaacttt ataaataggg aacgggcgtg ttggctctcc tgcagccctg 45240
ggtcactttg aaaaatattt gcttaatgag taacagcgag gtgtgggctc cactctgctg 45300
tgtagttagt ttctgctcct ttagtctgag cacctgagga cctgctaggg tctttgctgc 45360
tagcctgact ctttgtatag gataatagct gtaccagcaa tgactagcat ctgtccacat 45420
ttcattccgg ttctcattcc atggtttgag tggttcgtgc taggaatgta gtggataggt 45480
tgccacagtt actggagcac cctcataaac aagccgttag agaaaaaagg agagagcttc 45540
atacatgcat aggatacgtt ttgatcaaat ccacagccct tcactctctc tctccccttt 45600
caacttctcc caacagcccc ctctccccat cacctttccc tcccaatttc acgtgctctt 45660
tctctaaatc cactaagtcc gtgcacctgt aggtacgtga gtgtaggact atctactgcc 45720
gcatggatag cctgtcagga gccccatccc caaagaaaat ggagtcttcc tccccgaaca 45780
gccatcaatt cctaacggct tctcagctag gggtaagaat ttatgactcc atctcctgcc 45840
cacgcaggct tttgactggc ttggttttat acaggtcttg tgcatgcagt cccaaccatg 45900
cacacttcat gtgtgcaggg ccctggcatt tctagcaaat actgtttcac tctaatcaaa 45960
tgatcctttt ggatcttaca agttttctcc tcttctttga gatccctgag ccttgtgggg 46020
gaggggctga gatgcatcgg tctcattttg cacctaacac tccaaggtat tctaggtatt 46080
ctattctctg tccgttgacc aggcgtaggt ctctctctct ctcttttttt ttttttttga 46140
ttcccatctt ctacactgtt ggaaggggag ggagctatgc tgattaaatg agctttgaga 46200
tctgttgaaa tcccaatttg tagccttagc agacaaaagc tggaaggaaa tgatgtatta 46260
gtgccagaaa agagattgga gttctggtct cccaaaaacc tttatgacaa gaccactgtc 46320
tgatttcact gcagacatgg ctagctagct ctgctcagca aggactcaga gaggcagcgg 46380
ggtacgaacg agacaaggaa acttgcaggc aaagatgaca ggttttcaga acagtccaac 46440
ttgtatgttt gtgcttattt tggccccact tttctttcca taattatttc cctttctcct 46500
acaggggtat atttgtgttt ttcatcaact tactaaagcg taaagactat ctactaagga 46560
acaggcatgg ctagggtgtg ggtctataga agtgactaca ggttatctgt agtctcccct 46620
tggagttcgc agaaaacgtg atgtttcatg gtaatcatca taaagcagaa gggagtggat 46680
ttcagtggaa gggaccggta tgtagaatag ccccagtgta ggacagagtc tgtgtcttca 46740
tctctgacca ctatgactgg gaagaggcag tgggactgtg tgtcgtggga cccttgaaac 46800
tatgaagatt cgttcagtgc aggagaagca gggtaataac atggcttgaa acattctttt 46860
tttttaaacc ttatgtatct ccagatctca catctccaga aagttcctgg cagtcttgag 46920
acactaatat gggttctggg aaccaaatgc aggcctctgg aagaacagca agtgcttaac 46980
cactgagcat cactcccacc tgccaacatt gaaaaaagaa gttttaatta atccttagag 47040
aattccattt agtgtatttt gattccattg ctcctgaagc tcctcccaga tcctccccac 47100
cgcttaactt acccaagttt ctctccctct cgcgcctcct tgcattgagt atagtttgtg 47160
ttggctaact gcttttgggt atcaggccac aatcaataag gaaaaaacaa aacaaaacaa 47220
acaaacaaac ctgtttctca tactgaggat ggaacctagg gttttcacat attgagcaag 47280
tgctctacca ctgagctgta ctcagctctc agatcgctcc agaagcctgc tggaggatgg 47340
aagctggagg tcagctgctt tcacagggtg gagatcacag tgccggggat agtggcggtg 47400
aagatgaatt ttctagaatt tactggtggt aagatgggag ggggtcaggt ggtctcaaag 47460
gaggcggact cctaggtgcc taaattgaag tctgtgattg gaaggatggg ctgggggcgt 47520
ggcgggtaga attagaaccc taagcttctg ctgtgtagtg agttaagttt gaagtgtcgg 47580
cgatgaacat tggcttgggc cttgattttg ccattttgaa atagctgact ctctgcaggt 47640
ccgaagcgca ctgagccatc gcgactgtcg ccaggcattt gggctgccgt ccttcctccg 47700
cagcatccag cagcacagac atctgtgtgt agagcaatgc tctgttcccc cttaaggttg 47760
cttcctctga ttgcattccc caaagtggca ttgccaggtc agaggaaacg aatgagtggt 47820
ttttatggcg ttcgctgcag attgccagat tgttttttag gaagacaatc aattcagcca 47880
ccagccacct ataaatgtgc tttctagtcc atgaatctgc cgcgacggga ctttctcatt 47940
tcaaattacg tatcttcttt ttaattcagc gatgtaagga cctttggtgg tctctgtgac 48000
agtttagtca tttctagggg cataataaac ttacttgcat gatgcttgac ttttaatgac 48060
tcatggtcct tctagcgagt agaagttatg ctaatcttat ttttatcaat tctacttatc 48120
attctggtta taggttctta ctagctgtaa tggcattgct ttatattcta ttgacttttt 48180
acgatcatgt ttacgtattt gctttgtttg tgtgcacgtg ggcatctctg tgtcacagtg 48240
catggaggtc agagacaatt tatggagtct gtgggtcctg gggatagaat tctctacctg 48300
tcaggcttag tgttaagccc cattgcccac tgatccattg caccaatact gcaccactac 48360
tgtactctac tataatatca tgaaaaaaat aggattgtgt tattaaacct tttcctttct 48420
gggtctgaga atattctttt tgttttgttt tttggatttt tttttttttt tttttttttt 48480
tttttttgcc cattttgtta ggaattcatc ctttgacagg tagttataaa gaatcctaat 48540
tgctttgaat tttataatgt tattggttga cttgttgata tttctggata ttggtgtcgt 48600
atatgtggtg ggaatcccct tggtgtgttc tgaaggctat atgtgcgtgt gtgtgtgtgt 48660
gtgtgtgtgt gtgtgtgtgt gtgtgtaatg gattctgtgg gtaaacacac aggggagtgc 48720
tgggcccagc tgattcacca tttcaggctg ttcttccgtg gagtcacctg ggacaggtga 48780
tagctgatat attaattgta cccgttcagg agaagatata cggagtattt tctgaactct 48840
agactagggc atcagagact ttttctgtaa agtgctgggc agtacggtta tcttatgata 48900
tctgtggtaa ctacttaatt ccacctttgt gcaagacatg tgcagacaat gtctcgaaga 48960
gtgagtctgg ctgtgtttca ataacacttt atttgtggat aatgaaattt gagtttcaca 49020
cagttttcac tggtgctata ttgctactca ttcattcctc ctcatttccc agctgtcaga 49080
ctataaaact gttgtaggcc tgcctatagg ctatacaaaa atagacggcg atagagtcca 49140
gcctgctttt agaccagggc attaatattg tgtgagagca aattggggca actcactttg 49200
gaaaaccctt acttaatcgt gttctgggca tctaaagtga gattattaat tgtaaatcct 49260
ttctatttta ttattatttt ttgttataag ccaaggttta tttcatttta attaattaac 49320
ttactttgag gtagtgtctc tggttgacta ggctgaccca aggctaacct tgaattgcct 49380
ccgttttaag tgctgggatt atggtgtgtg ctggtctcgg aactcaccag gcaggcgctc 49440
aaatagctga gccagccaca tccccagaat cccaagtgtt tgcttgtttg tttttaatat 49500
agtgtgaaaa gtagccttgc tttctcttgt ctttatcttg acgtctgctt taaaacaaaa 49560
cttctacagt gtgctctgtg ttcggggaag tgagtttcag gattataatt ttttattttt 49620
taacagtatt attattatta ttggtatttt tgagacagag ttgctctgtg tagccctggc 49680
tgtcctggaa ctcactttgt agaccaggct ggccctaaac tcagaaatcc gcctgcctct 49740
gcctcccaag tgctgggatt aaaggcgtgc gccaccacgc ctgcataatc ttttattaaa 49800
ttaaataaaa gaaataacca atttttggtg tttgaggaag aatatcccta tggaaatcag 49860
cttgaatagg aaatcagtgt ctagcacaag ctggccttgg attttgtgat gttcccgtct 49920
ttccatccta aattctgtgg tcataagtat ggaccaccat gtaaataggc aagtaccact 49980
agtacatagg catgcatcca gatggcagtt cttttcttat ttgcttgttc tgagccagtt 50040
tgggtgtgga tccctgcctc actttgaata cactatgtat atccatctgg ccttgaactc 50100
actaagtaca ccaagctggc tttgaactca ctgcatacct caagctggcc ctgaacttgg 50160
gatattcctc atgcctttgt tcccaaagtg ctgggactac agtggatgcc actgtgatgg 50220
agttgggtta cacctttaaa caaaaaagtc tagagtttgg aggctggaaa tgtaacctgc 50280
ctagcacaca gacaaccttg gacttaattg tagcatgaca aaacaaaaca aaacaaaaca 50340
aacaacaaca aaaacaaaac aaacagcaac aacaaaaaca aaacaaaaca aacagcaaca 50400
aaacaaaaca aaaaaggaaa catttctcaa atttatactt aaaatagaat tgaaatgttt 50460
taaaacattg tctattcaca ggtaataaac ttaaagtcta gtaaaataat aaattggtgg 50520
ggtgataatt tcccaaactg gtattccatc cagcaattac catgtcagac atgttctcca 50580
tactccttct gtgtagctaa ttatcaaaac aacttagaat ggccgttgtt attgctgtgt 50640
ccattttaca agcgaggagg tagaggcttg gacgttggct ccttcccagg ttagaaagat 50700
agaaaaaaaa aatgtaattt tcttcagctt aggaaccaga ttcaccagct gacactcaca 50760
gggtgtcttc aattcacacc cgaccctatt tgcttcaaga tagctaccgg ttggaaggct 50820
agattccaca agacggactc taacggacgt caggtatcaa gagtaaaagt caggttataa 50880
cctgtgcttt ctgttgtctg actgtaagtc agagttccta tggctctcag ggggttcagt 50940
taacttgtaa gcatggcctc acatatctca gggaaacact ttctgaatat ggctctcttc 51000
tacagaaagg agacccatga taaagcatgc agaggaaggc atgcttaggg cagccatata 51060
aggagcaccg tggagctgtg gagctactgt gtctgtctgc cttggacacc gtgagctctc 51120
tgaaccttgt cctttcagag ttttatggag atgctatttc ataggcacaa tttactacgt 51180
cattagacac tggtgactaa acttaacctt caacccctct cctcatccca gagattgagg 51240
tagaactgaa agtagcaagc tgaatataaa aaccttgtgt gttctgacca ctggtctcca 51300
tcttggtggc accctctcag agcctccgtc ccctgtcatt ttatcaccac ccagaagacc 51360
ctaatcacgc tggctgtgag cttccctact ttgtaggatc catgggaaga gaccacatct 51420
atattcctta ttatcacagg atcgcggcca gcagatacct gggcgagcag ggcgtatgtg 51480
gtacattcta ggcttaaatg gtttttcctt atactttgaa gcctcagttg ctgcactggc 51540
ctgggttgta tgctcttcca gacatgccca gtcagcatga agttgcatcc ttccatcatc 51600
tactgttttc tatgacatac tatttcactt attactcact gggcatccta ttggcatctc 51660
tcagtaagca gagaataaag aaattactac tgtgttggag ggagacgggg ctgtggtcca 51720
gtgactgatt gctgtatgca ctttctcttc tgcattgcgg gttccagaga aaacagctcc 51780
taggtgaaat cttccctgtt tttttcctct ccagtgtccc ctgagcttgc ctccttctgt 51840
tcctacagtc agcacattct ggctctggca ttctctatag tcaccagctt gaaaaacagt 51900
ccctgcttcc tttgctttgg caataggaga cggctctccc tccttcccat tcctctcatc 51960
cctcccatcc tcctcttcct tcatctctcc ctctcttcca tccttccttt cttccttcct 52020
ctttccttct tttcagagaa ggcagtagaa atgaaagagc caaccaagtt tatataacat 52080
aactggaaat accctgtctg tgatttgtgg aacctttgtc cttgaaacgt ttgtttgtat 52140
gtatcccacc tgccccacaa cttcagatct ggggaattat agccatccag tgtttatatt 52200
acaaattaaa aatgatggcc cagctatctg gtcaacaatt ctgagggctg agcagctctg 52260
tctttgtcat caggtatcat atttcatagt catcctcata ggcaaacctg attaccttac 52320
aatctctaca gtaactacac acacacacac acacacacac acacacacac acacacacat 52380
atatgtatat acacacacac atacatgtgt gtgtgtgtgt gtgtgtgtat ggaaaaattc 52440
tatatcaaag tccagagcaa ttttcctgct tcttactaag gaaaagcagg tccacctctg 52500
tcttaagttt gctcgtttta taatgaaatg ttactagaac ttgagaggaa atgaaagtaa 52560
tgtctgcctg gtgcagggac gatggctcag tgggtaagat gctggcttac aaatgtgaag 52620
agatttgagt ttgaatcctt agcactcatg taaaaaggct ggatgtggtc ttgtgagcac 52680
ctgtaacccc agcattatgg aggctggaga caaggaggct tgctggagct tgctggctgc 52740
cagtcttgtt aaaatggcaa gctccaggtt tgatgagaga gccctgtctc aagtcaacga 52800
agtggagagc gatggagtag gacactctac atcctcctcc ggcttccccg tgggcatgtg 52860
cacctgtaca cacacatgca tataccacac acacacacac acacacacac acacacacac 52920
acacacacac acacgctaac gtcaatggca cagatctgtt gtaaccttta agctaccaag 52980
ggatctcttg tttatctgaa ggatgaggta atggaagtgg aattgctgaa caataagtag 53040
atgtctacat tctgacatgg attcacacat ccgggtgctt cttgtcttca gtcaggccca 53100
cctgtgctgt aaactgcaag tgacacatca taggtgtgct ataggccacc aggatgcaca 53160
gtgagactct ggaagccttc acagtcagtc acctgcacca agtgctgctc tccacttgat 53220
ctctgcttct ctcgtttaag cttctaatca ttcaataaac acttgtagtg tttttggttg 53280
ttgttgtttt taaccaaata cagtttgaga cagcatgctg atacttgatg catctatcca 53340
ctgttgtagt tgacattcct tttttttttt gattagatgt tttctttatt tagatttcaa 53400
atgctatccc taaagttccc tataccctcc ctccgccctg taggtgacat tcttagatac 53460
atggaatttt cataataatc gcagtttaaa cacagagaga atctaacctt cttatattgc 53520
ttataatctt aagcacaaag tgtaatcttc tctttttttc tttcttttaa atgagagaag 53580
aatatttgaa ctctttagta tattagcttt ttattttgag tatcacgaag aagctaattc 53640
ttagaagcca attatagttc tgttaagaga gagtaatggg gggctggaga gaaggctcag 53700
aggttaagag cacaggctgg ccaggcatgg tggcgcacgc ctttaatccc aggacttggg 53760
aggcagaggc aggtggatct ctgagttcga ggccagcctg gtctacagag tgagttccag 53820
gacagccagg gctacacaga gaaaccctgt tctgcattat agattccagg gaagacacac 53880
agagtataag tgtgtaagta agaaaacgat gacaaccata tagggaaaag aagaaaccga 53940
ggagggcttt acaattgggg atgggaggca gggagagcac ccaggaggaa gtcttgtctc 54000
tctggatgat tttgcttttt ctcagacgtc agggggaagt gagagtttga agccgagtgt 54060
gaaggaacca gattgagcgt gtgagttaga gtgggtggag agagagagag agagagagag 54120
aaagagagag agagagagag agagagagag cgagcactct gctcataaag aaacttatgg 54180
gggagaccag gaagtttcta tgagcagctg gtctctgcaa tgtttgtatt tctttagatg 54240
cccatgctgg gagctggcag atttcaccta taaagggcca agtgataaca gtaagctaac 54300
tgaggtttct gggcagaatg gtctctgtca tagctttgtc gctttcccac agtagcctga 54360
aagcagccac gagtgctagc tacatcagtg tctggactct aggaagcttg tttataagac 54420
gagctggtat gttggcattc ctttgctggc ccctggcttg aaggatggtt tgcttattat 54480
tttcctagtg ttcattaggt agttgagcaa gtgaggaagt atagtctgta cagtagtccc 54540
tggccttgag ctgcttataa gcattaagga aagataagta tatacactta cggtactgcc 54600
aaccaacatt aagagacact atgtaattag acgctggtac aatagacaga aacaggaagt 54660
gcgatgggct agttgctcat ctgcttggca tctgggtgtt tagaaagaga tttaaaggct 54720
acataaggat ggcaggattt gacagaatca caacacgcag gagggtagaa ttggttgaat 54780
attactactg agttcaacct gctcatttcc taagtgagca acccaggatc ctgttgactt 54840
cccaacaggt tgggtaagaa catgccttct cttttcaaaa tctttgtcca gttcttttcc 54900
tgactttttc tgcttgatcc acccagggat gtttatgtac gtatgtttgt gtatatgttt 54960
tatattgtta ggggtgagag aatggggtcg ctccaggtta tcgattgcat ttaggatgtc 55020
aaaagactgg gaccagggtg atcgtgtctg ctacttggac tgatgtggag agaagagaag 55080
ctaggtgagg ggtatgggag ggaagaagca gttgtgcaca atagaaaact ataccctgac 55140
ctatatacat gcaagaaagc agtcaatgaa gtcttggtgg gaagaccctc tgaagtaaga 55200
catacccatc ctgttggttg cgtgcctagc ctttaatggc taagccagct ctgtagaata 55260
tgctcattct gttgaagaac tctgaattgt tagagtgaga cagtttgtat gttaaaacag 55320
acaggtcttg gtgatgtaac agaagttagt aaaagagaaa tcacagagca acatggttgg 55380
ctttttttcc ctttgcatac acaaaaccaa ctcaaacaag agaacgggga agctgagaat 55440
ctgtagttcc aaattgctag gactattaca tagatgttta ttgagggggg gtggaagtaa 55500
aatgctaata tcaagttatt taaaaatgcc aggttaggta gagaaggggg tgactctgac 55560
tgtgagattg ggttgtatcc aaaatgtggc tcaggatcaa agaattttac agtcagaggg 55620
gtcttggttt agtgttaggg actcaagagt tagttagata ccagaaacac tcagattgat 55680
taaaaaggca agaaaaaaaa aacctcacag ccaaacaaaa taagttcctc accctgttgt 55740
atactcacaa cgatctcaga gataagacga ggtacatgaa gaaagtactt tcaaaaatca 55800
tctcagacag tattattttt tctttttcca ttttcatgtg tgtgtgtgtg tgtttgcgtg 55860
tgtctgggct ctcatgtgtg gttccatgtg cacatggagc cccaaggttg acattgggag 55920
ccattctcaa ttgctcttcc ttcctatttg gcgaggcagg tgcttaagcc aaacccagag 55980
ctcagtgata tgtgtcatct ctctagcctg tttcttctag ggatccgctg acacctctgt 56040
gatggaatta caggtagact gatgtatcca cttgatacac actcttcccg ggcaatttca 56100
gttttatact caaaagccgg aaactatgtt agatctctct gacctgtctt agccatgtct 56160
atacacatgg tgggggttgg gagaggaatc aagggtctta attggaagga cccagcctcg 56220
gttttcttga ctctcactat ccatgacctt gtctcccctt tcccatttgt ttgtcttctc 56280
ctctagggtt agctttcact ataatctttt tatattgtgc aggggccatc tttaaatatt 56340
gtcttccatt tggtctattt ctgcccagat ccatggggtt agagggaaga gctaatgtgt 56400
gaggtgcaca tatgtgcatg tgtggatgtg cgtgcgtgcg tgcgtatatg tgtgtgaact 56460
atgtatgtat gtatgtatgt atgtagaggc atgttctcag gtagctcaag tgactctcaa 56520
acttgacgtg tagccaaaga tagccttgaa ctcctgatcc tcctacctca gcttctcaag 56580
tgttgggttt acaaacttgc gccatcacaa ggggatattg ttttgttttg ggacaaagtt 56640
tctttatgta gctcagactg gtctggatcc tgtgatcctc ttgtctgagt ctccctagta 56700
ccggcaagta cttccacaac ttggaagggg aaactcttgt ttagatacag tttttccttc 56760
ttcttcttta aatagcacag tgggattagc tattgactct ggaattggga gagactttag 56820
aggaccctgt agtcttgttt gagtaataag ctctgctctc aacaggcctt ccctctgatt 56880
aggctttgca aagcagagct gctctgtttg agacagaagt gagggggctt ggagcctacc 56940
tcccattgct ccttggcaag aggcagccct gtgatttttg tccagttcag cgcttgcttc 57000
ttgtcccact ggtttcttcc tccatccact tcgctaaaca cagttaattc acactctcct 57060
ttattctgtt tgcaggagat agatgaggta attttatagg tcagcattat agtcccttaa 57120
aaactgataa aggagccagg catggttgtg caaactagcc cagctccgtg gctcatacct 57180
gtaatcccag cagcaactgg agagtctgag tcaggatttc cacgaggcca gcctgggtta 57240
taaaataaga ctctatctca aaacaaaata tcttcaaaat aattttaccc ccacgaaatc 57300
aagaatccca aatggagcaa gcatggtata gagtgtaggg aatgtgcagt tgctgggtgg 57360
ggtttgaaca cagctaagtg accccaacaa gtcagacatc aggaaagaac ctaccatccc 57420
tgtcttagaa caaaagtctg gacccttgtc tagtctggtg ggtgttgtca gcaatgtgca 57480
cactcagggt ggctccctgg atcaggagcc ctgggtgggg aaggctgggg ttgaggctcc 57540
atttcctaga gctttgtgta tctccccagg gtgcacactt ttgagtctac agtgggggtg 57600
gggcactaat cttgtactcg ggctccattg gacagatggt ttcctccacc ctgggcatct 57660
gctgaactcc ggatagggtg tctgggctgg ttgtgcaagt agagggagca ggaaaaggaa 57720
gggccaagcc aaacgctgag agaggagact taccaccaag tagcaggatc ttctctttct 57780
caatttccaa tatgaaatta aatttcccaa caagaaaacc aaccactatc catcgccaac 57840
cacctctgcc cctactttca gactcagaag gaagaaaact aagtatatcg taaactctaa 57900
ggaggaaacc tcaagaaccg gtgagaggcg gggaagtacc ctggccccac ataactgtgg 57960
ggttgggaaa agaatagact ggggtcaagt ttcgagatgc taagaagaca gactcttgat 58020
caccttgcaa gcagtttttt ttctttttct tttgctttgt tctttcagtt accgatgtag 58080
ctgtaaatct gtaaatctag aaggaatttg ttcggtagct ggtagcttgg ggcagccatg 58140
attttcatac aaatttctcc atctcactga ggatggcaaa gactatcagg gccttcattt 58200
tgacagcccc agggaagcag tcactctagt cttttgctcc ctgcttctct ttcacagcat 58260
ctcaggactt ggaacttggg atacccccag gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 58320
gtgtgtgtgt gtgtgtgtgt gtggtttgtc cagacagggt gtctccatgt agccctggct 58380
atcttagaac tcaattggta gaccagacta gctccaaact cagagatccg cctgcttctg 58440
cctcccaagt gctgggatta aaggcatatg ctaccacacc caacgggtcc tccaagtttt 58500
taatctggaa gttggtgaaa ctctgacctg ctgggtgaag tttttatttt agaacatgaa 58560
cactgagtta ttcttgctgg acccaagctc aatgggtaga tttctcaatg gatgcctgca 58620
gggattgtgt ctatcggttg tggccttcag agactggaca aactgcgttt gaatctaaaa 58680
gcaccagctc cattgtttaa tgcacataac aggactgtca aaagtatggc tgtttgttaa 58740
aacaaaacaa aacaaaacaa aacaaaacaa aagtttatca tcaggtatgc aggtgctata 58800
gaaatgacaa ctttggcaca cacctccctc tttctgatgt caagttggtg tggtacccgc 58860
cagatcttga acagtggtga tgacctgtta ttgctgttgc tgttgctgtt gctctgttcg 58920
cctctgctcc tctatctgac acctctctta tttctttcag cttggattcc tcagcaccat 58980
cacagct 58987
<210> 2
<211> 3521
<212> DNA
<213> 人工()
<220>
<223> 合成
<400> 2
tggtacattc tggtgccaag tgtggccatt cccctggcta tcgccttcct cttcttcttc 60
atctgtgtgt gccgcaataa ccagaagtct tcatcaggta ccgatttaaa tgatccagtg 120
gtcctgcaga ggagagattg ggagaatccc ggtgtgacac agctgaacag actagccgcc 180
caccctccct ttgcttcttg gagaaacagt gaggaagcta ggacagacag accaagccag 240
caactcagat ctttgaacgg ggagtggaga tttgcctggt ttccggcacc agaagcggtg 300
ccggaaagct ggctggagtg cgatcttcct gaggccgata ctgtcgtcgt cccctcaaac 360
tggcagatgc acggttacga tgcgcccatc tacaccaacg tgacctatcc cattacggtc 420
aatccgccgt ttgttcccac ggagaatccg acgggttgtt actcgctcac atttaatgtt 480
gatgaaagct ggctacagga aggccagacg cgaattattt ttgatggcgt taactcggcg 540
tttcatctgt ggtgcaacgg gcgctgggtc ggttacggcc aggacagtcg tttgccgtct 600
gaatttgacc tgagcgcatt tttacgcgcc ggagaaaacc gcctcgcggt gatggtgctg 660
cgctggagtg acggcagtta tctggaagat caggatatgt ggcggatgag cggcattttc 720
cgtgacgtct cgttgctgca taaaccgact acacaaatca gcgatttcca tgttgccact 780
cgctttaatg atgatttcag ccgcgctgta ctggaggctg aagttcagat gtgcggcgag 840
ttgcgtgact acctacgggt aacagtttct ttatggcagg gtgaaacgca ggtcgccagc 900
ggcaccgcgc ctttcggcgg tgaaattatc gatgagcgtg gtggttatgc cgatcgcgtc 960
acactacgtc tgaacgtcga aaacccgaaa ctgtggagcg ccgaaatccc gaatctctat 1020
cgtgcggtgg ttgaactgca caccgccgac ggcacgctga ttgaagcaga agcctgcgat 1080
gtcggtttcc gcgaggtgcg gattgaaaat ggtctgctgc tgctgaacgg caagccgttg 1140
ctgattcgag gcgttaaccg tcacgagcat catcctctgc atggtcaggt catggatgag 1200
cagacgatgg tgcaggatat cctgctgatg aagcagaaca actttaacgc cgtgcgctgt 1260
tcgcattatc cgaaccatcc gctgtggtac acgctgtgcg accgctacgg cctgtatgtg 1320
gtggatgaag ccaatattga aacccacggc atggtgccaa tgaatcgtct gaccgatgat 1380
ccgcgctggc taccggcgat gagcgaacgc gtaacgcgaa tggtgcagcg cgatcgtaat 1440
cacccgagtg tgatcatctg gtcgctgggg aatgaatcag gccacggcgc taatcacgac 1500
gcgctgtatc gctggatcaa atctgtcgat ccttcccgcc cggtgcagta tgaaggcggc 1560
ggagccgaca ccacggccac cgatattatt tgcccgatgt acgcgcgcgt ggatgaagac 1620
cagcccttcc cggctgtgcc gaaatggtcc atcaaaaaat ggctttcgct acctggagag 1680
acgcgcccgc tgatcctttg cgaatacgcc cacgcgatgg gtaacagtct tggcggtttc 1740
gctaaatact ggcaggcgtt tcgtcagtat ccccgtttac agggcggctt cgtctgggac 1800
tgggtggatc agtcgctgat taaatatgat gaaaacggca acccgtggtc ggcttacggc 1860
ggtgattttg gcgatacgcc gaacgatcgc cagttctgta tgaacggtct ggtctttgcc 1920
gaccgcacgc cgcatccagc gctgacggaa gcaaaacacc agcagcagtt tttccagttc 1980
cgtttatccg ggcaaaccat cgaagtgacc agcgaatacc tgttccgtca tagcgataac 2040
gagctcctgc actggatggt ggcgctggat ggtaagccgc tggcaagcgg tgaagtgcct 2100
ctggatgtcg ctccacaagg taaacagttg attgaactgc ctgaactacc gcagccggag 2160
agcgccgggc aactctggct cacagtacgc gtagtgcaac cgaacgcgac cgcatggtca 2220
gaagccgggc acatcagcgc ctggcagcag tggcgtctgg cggaaaacct cagtgtgacg 2280
ctccccgccg cgtcccacgc catcccgcat ctgaccacca gcgaaatgga tttttgcatc 2340
gagctgggta ataagcgttg gcaatttaac cgccagtcag gctttctttc acagatgtgg 2400
attggcgata aaaaacaact gctgacgccg ctgcgcgatc agttcacccg tgcaccgctg 2460
gataacgaca ttggcgtaag tgaagcgacc cgcattgacc ctaacgcctg ggtcgaacgc 2520
tggaaggcgg cgggccatta ccaggccgaa gcagcgttgt tgcagtgcac ggcagataca 2580
cttgctgatg cggtgctgat tacgaccgct cacgcgtggc agcatcaggg gaaaacctta 2640
tttatcagcc ggaaaaccta ccggattgat ggtagtggtc aaatggcgat taccgttgat 2700
gttgaagtgg cgagcgatac accgcatccg gcgcggattg gcctgaactg ccagctggcg 2760
caggtagcag agcgggtaaa ctggctcgga ttagggccgc aagaaaacta tcccgaccgc 2820
cttactgccg cctgttttga ccgctgggat ctgccattgt cagacatgta taccccgtac 2880
gtcttcccga gcgaaaacgg tctgcgctgc gggacgcgcg aattgaatta tggcccacac 2940
cagtggcgcg gcgacttcca gttcaacatc agccgctaca gtcaacagca actgatggaa 3000
accagccatc gccatctgct gcacgcggaa gaaggcacat ggctgaatat cgacggtttc 3060
catatgggga ttggtggcga cgactcctgg agcccgtcag tatcggcgga attccagctg 3120
agcgccggtc gctaccatta ccagttggtc tggtgtcaaa aataataata accgggcagg 3180
ggggatctaa gctctagata agtaatgatc ataatcagcc atatcacatc tgtagaggtt 3240
ttacttgctt taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca 3300
attgttgttg ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc 3360
acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc 3420
atcaatgtat cttatcatgt ctggatcccc cggctagagt ttaaacacta gaactagtgg 3480
atcccccggg ctcgataact ataacggtcc taaggtagcg a 3521
<210> 3
<211> 2654
<212> DNA
<213> 人工()
<220>
<223> 合成
<400> 3
ataacttcgt ataatgtatg ctatacgaag ttatatgcat ggcctccgcg ccgggttttg 60
gcgcctcccg cgggcgcccc cctcctcacg gcgagcgctg ccacgtcaga cgaagggcgc 120
agcgagcgtc ctgatccttc cgcccggacg ctcaggacag cggcccgctg ctcataagac 180
tcggccttag aaccccagta tcagcagaag gacattttag gacgggactt gggtgactct 240
agggcactgg ttttctttcc agagagcgga acaggcgagg aaaagtagtc ccttctcggc 300
gattctgcgg agggatctcc gtggggcggt gaacgccgat gattatataa ggacgcgccg 360
ggtgtggcac agctagttcc gtcgcagccg ggatttgggt cgcggttctt gtttgtggat 420
cgctgtgatc gtcacttggt gagtagcggg ctgctgggct ggccggggct ttcgtggccg 480
ccgggccgct cggtgggacg gaagcgtgtg gagagaccgc caagggctgt agtctgggtc 540
cgcgagcaag gttgccctga actgggggtt ggggggagcg cagcaaaatg gcggctgttc 600
ccgagtcttg aatggaagac gcttgtgagg cgggctgtga ggtcgttgaa acaaggtggg 660
gggcatggtg ggcggcaaga acccaaggtc ttgaggcctt cgctaatgcg ggaaagctct 720
tattcgggtg agatgggctg gggcaccatc tggggaccct gacgtgaagt ttgtcactga 780
ctggagaact cggtttgtcg tctgttgcgg gggcggcagt tatggcggtg ccgttgggca 840
gtgcacccgt acctttggga gcgcgcgccc tcgtcgtgtc gtgacgtcac ccgttctgtt 900
ggcttataat gcagggtggg gccacctgcc ggtaggtgtg cggtaggctt ttctccgtcg 960
caggacgcag ggttcgggcc tagggtaggc tctcctgaat cgacaggcgc cggacctctg 1020
gtgaggggag ggataagtga ggcgtcagtt tctttggtcg gttttatgta cctatcttct 1080
taagtagctg aagctccggt tttgaactat gcgctcgggg ttggcgagtg tgttttgtga 1140
agttttttag gcaccttttg aaatgtaatc atttgggtca atatgtaatt ttcagtgtta 1200
gactagtaaa ttgtccgcta aattctggcc gtttttggct tttttgttag acgtgttgac 1260
aattaatcat cggcatagta tatcggcata gtataatacg acaaggtgag gaactaaacc 1320
atgggatcgg ccattgaaca agatggattg cacgcaggtt ctccggccgc ttgggtggag 1380
aggctattcg gctatgactg ggcacaacag acaatcggct gctctgatgc cgccgtgttc 1440
cggctgtcag cgcaggggcg cccggttctt tttgtcaaga ccgacctgtc cggtgccctg 1500
aatgaactgc aggacgaggc agcgcggcta tcgtggctgg ccacgacggg cgttccttgc 1560
gcagctgtgc tcgacgttgt cactgaagcg ggaagggact ggctgctatt gggcgaagtg 1620
ccggggcagg atctcctgtc atctcacctt gctcctgccg agaaagtatc catcatggct 1680
gatgcaatgc ggcggctgca tacgcttgat ccggctacct gcccattcga ccaccaagcg 1740
aaacatcgca tcgagcgagc acgtactcgg atggaagccg gtcttgtcga tcaggatgat 1800
ctggacgaag agcatcaggg gctcgcgcca gccgaactgt tcgccaggct caaggcgcgc 1860
atgcccgacg gcgatgatct cgtcgtgacc catggcgatg cctgcttgcc gaatatcatg 1920
gtggaaaatg gccgcttttc tggattcatc gactgtggcc ggctgggtgt ggcggaccgc 1980
tatcaggaca tagcgttggc tacccgtgat attgctgaag agcttggcgg cgaatgggct 2040
gaccgcttcc tcgtgcttta cggtatcgcc gctcccgatt cgcagcgcat cgccttctat 2100
cgccttcttg acgagttctt ctgaggggat ccgctgtaag tctgcagaaa ttgatgatct 2160
attaaacaat aaagatgtcc actaaaatgg aagtttttcc tgtcatactt tgttaagaag 2220
ggtgagaaca gagtacctac attttgaatg gaaggattgg agctacgggg gtgggggtgg 2280
ggtgggatta gataaatgcc tgctctttac tgaaggctct ttactattgc tttatgataa 2340
tgtttcatag ttggatatca taatttaaac aagcaaaacc aaattaaggg ccagctcatt 2400
cctcccactc atgatctata gatctataga tctctcgtgg gatcattgtt tttctcttga 2460
ttcccacttt gtggttctaa gtactgtggt ttccaaatgt gtcagtttca tagcctgaag 2520
aacgagatca gcagcctctg ttccacatac acttcattct cagtattgtt ttgccaagtt 2580
ctaattccat cagacctcga cctgcagccc ctagataact tcgtataatg tatgctatac 2640
gaagttatgc tagc 2654
<210> 4
<211> 106315
<212> DNA
<213> 人工()
<220>
<223> 合成
<400> 4
cacaggggca ctgcattctg ggaatcaacc tactggcggg gtgatttcat ttcgtttctg 60
acttttgtgt tttggtgtgt atgtatgtgt ttaacagagt gtatggccgg tgagtttggg 120
ttctttcttt ctttctttct ttctttcttt ctttctttct ttctttcttt ctttctttct 180
ttctttcttc cttcctgaaa gtgaatgtat aaagccttta caatgtataa ctgttggaaa 240
atgcccacca ctaaattttt ttttaagttc cacatattct ccatttttgc cttcttatat 300
atatcttcaa cactattctg tgcactttaa aaacttaaca taaacgcagt gtgacttctc 360
ccatatgctg ggtcccgaga ctctcaactt cttaaaaacc taatggcatc ttgtgactcc 420
tagaagtaga cataagtctt tcaaccttca cacctactct ttctgtttta attattattg 480
ctatttgtct tattgtttgt gctttacaag cgttcttgag gacggaggga atctacgacc 540
ctgttgatga ctgtaactct attcgacttt gagttgtctt cttcatgtct tgttatatag 600
ttcatattca tggctgaaac ttgaccatac tccctagcgc tgattgtatg gttttcgtct 660
ggacaccgta cactgcctga taacttgtgc acctcttaac gctactatgc tctgggctgg 720
agaatgaaat ctttaagtca ccaggacttg ctgtttcagt ggcttgacac ctgggccacc 780
aaagaactcg atcttcatct tttagggaca cctctgctgc accttggaaa gccaacctta 840
agtgccagtg gcactttatg cccagctttg ctttgaaaga tatctttctt gtttttttta 900
tccttctctt tctctctttt ttttaaaaat acacatagtc aataggtcca gtctgccctc 960
aaggccttgc tgggttttct tcatcatcca atcactttca ttaaaaatgg ctgcagctgt 1020
aagaactctt gtctgataaa ttttcaacta tgctctcatt tatctacctg ccctctgatg 1080
ctcagtcgtc agactctaat gcaaaggtgg acgtcggctg cctttgcgtg ggcgggctta 1140
gtggtgagga actgatatca gaaaaaaaat gccttcaagt atactaattt attaataaat 1200
attaggtgtt tgttacttgt gtggttttgg tatatttact actgaacttt cgcctttccc 1260
tctgctcagg ttctagccct gttcatctct tggggaagga tgtgtgttct gaaacccttc 1320
tcctgtccaa tctgtaaatc atgaatatta ttagcaaaag tcccttttgg agaggtactt 1380
ggaggttcac tgcacagggc tctgataagc actgccaagc ctttcctagt ctttcggagt 1440
taaaccttag gtaacttgat acctgtagga cgatctgcac acattcacag gcttctagcc 1500
aaaacctcac tgtccctgac gaactccaga gggcttggtc agcagtgagg cggatgtggt 1560
cctgtgttgg tgggatatct caagctcact gcaggttttc ctaagcttgg accccacctc 1620
tgcggaattc caatgatcaa acgctagcaa ctttaacatc ctctttttgt gagaacctgg 1680
aagctgatac tgtgtatact gtgacccccc acgtcaacaa ctgggactgt cttccggttt 1740
cactcatctc tgtgtggcag ctttcaagat gaacatcctt gtttcccttc cctcttgttg 1800
gtgcatgcct ttagtccatt ggaagagaga ggcaggagga tctttgattt tgaagctagc 1860
ctgggagttt caggacagcc tggctacgct aactaaaaaa aaaaaaaaaa aaaaaaaaaa 1920
agatcacaca tgcgcacaca cgaacacaca catacagagc aacaagaaca aacaagaatg 1980
ggtcagttat gatgggggag gaaacaggtt ttgtcaggtt ctcactgtgt cagaagattt 2040
agaactgaga catacaatcc attcattaat tactagtatg ttaagtttat agtttattag 2100
taatttggga attttttatt aataacccaa atttgtggtt ttatatttta caacatataa 2160
agtttaatta ctttattgga tctttaaatt tgtcttaacg ggttcctatt attatgccca 2220
ttttacagat gaaattgggc ttgtaaagct aagtatatga gatggtttct tatcactaga 2280
acagagtccc tgaaaaggaa gaaaagaaat tctttaaggg aggaaacgtt gatcttaact 2340
catggtttcc aaggctttaa gtccatggtt ggctggctct gttgcctttg gttgatggta 2400
aagcagaaac ctggtaagaa aacacgacgg tggaaggttg cttacctcct ttcggccagc 2460
aagcagagag acacaggaag agtcttggga caggataact cttcagtggc acaggtccag 2520
tgaccttcta ctagctagaa ccccctccct accttatagt ctattcagct atgaacacat 2580
ccatggtcga atataccact agctgaagcc caaacctcca atagatgagc ctttgtgggg 2640
gacacttaat atccgaagca taaaaccaag gaatgtgttt aagccctcac tgagaaggtt 2700
agcaaggcta ggtttgaatc cgtgttgtgt atgttttggg aagaagggta gagcgagtgg 2760
ctgtaatcta agactgttca ttctctttat aagatcactg accagaaacc tgttgccacc 2820
tgaaacagtg ggcagaaaca tggcagtgaa atctgtctgg gtcatgagta aagttcaaat 2880
gcaagttaag taagtggtac aaacgtaggc atgagaacta aacattagca ttatatggtg 2940
atcccatgat gcatagcttt cccagaaggc aatgcaccat cagctacttt cttaaagtac 3000
ccagagtcaa gtgtgatgga tggcacacac ctggaaccca gcactcactt gcaggctgga 3060
agaccaaggc cttagggtca gcctggggag agggctcagt cagtaaacca tttgccacac 3120
aagcctgaga acctttggat acctggcaca gcaaagtaca gggctctgtg gtgcacacct 3180
acagtctccg tgttgggcag acagagacag gaagatccct ggggcttgct ggctggccag 3240
tctagctgaa ctggcaagca ccaggctcag gcaagtcact ccatctcaaa aaaataaggt 3300
gtaaaatggt ggaagaaggc atccaatgtc caactgcagc ctctgcatat gtatgcacaa 3360
ggtcatacac acacaaacac agaggaggag gaggacgagg aggaagagaa ggaagaggag 3420
ggattcaacg ttagcctggg ctacatagta agaccctgtc tcaaaacagc catatagcta 3480
ttggagttat agttcattga catttgatca acaacactgc agaaactggg tgtgacattg 3540
catatctccc aattctttca ctccagaggt gaaggcagga aagataaaaa gttcaaaatc 3600
atctttgggt gtatagcaag ttggagacca gcctgggaca cattagatgc tgtaaaaaaa 3660
aacaaaccaa acaactgaaa taaaacaaaa attcagcata aaatactaaa atatgtgact 3720
ttctgattaa agctaatgat agcaccattt gtaccataga aaggtcttct ctggcttgcg 3780
cttcttcctc tgaggagtat agacagctga aaaggaaggc tgctagtgtg agggcagagg 3840
agacaagaga gcaaccagaa gaataagaaa cagaagcaac tgttgggaga tccaagccat 3900
gttatgcagg caggcaggag aaggagtctg ttcaccaatt tgaaggacta agaaggagtt 3960
tgtgacccct gggaaaagac tacagactcg atccaattat aatgaaaaga tttgttgatt 4020
agctgctagc tggatgagta atctctgagc caacttcgag attacttcgc agaagggtta 4080
cggggaagga ctttaaaagg agaatatcac acaaagacct tcaatatcta ggcaagcaag 4140
taacaactgt tctattttga caaattaagt gattgaggcg actcaaaaca atcttgggtt 4200
atctgtgcaa caagttacag aggcaaaaaa aaaaagttag tcataacaag tgttatgtat 4260
ggggaggaag gtgtgactga gtcagggtta ttggaaattt atcttccggg gaatggagtt 4320
agagactagt gggtatggaa atgaatgcct agcataaaac ggagcttctt tcattttctt 4380
cagagagtaa tatagttcct gtgggctgtt ttaggctgaa ctcaattaga tagggctgct 4440
tttcaaggag aaactgcttc aaggagagga aggagctggg cgagcatctg tggttctcca 4500
actttcatgt aaataagtca cccgggagtg agcagcttgt tctctttaaa aaaggctgat 4560
tcccacaatc tgattggaga ggtttgtggt gaaattcaaa aatgaagccc ttgcaggttt 4620
ttggaccaca cttagaaaac tatctttaga gaatttccgt tcctgccaat ggggacaaga 4680
acagctaaga ggagctggtt agactcgcac cttcagaggc ctcctgtcta cccttttaat 4740
gtgcaaatga gatacctgaa ggtcctgctc acaggcagac tctccaggcc tcttctggga 4800
aagggcagct ggcatcctgt gttgctgcca agctcttggg taatacaggc actgctgggt 4860
ttttcttttt ccccgtgaaa ctgggtagtc tgggatgact ttacctttca ggaaaggggc 4920
agaacaaaca caggagtcga tcactcattt cacaggaggg aaggaaacac actttgatga 4980
gctgaagaaa cacccagaac caagcaaatc tggtcaaaac ttacaactgg ttggggctgg 5040
gcttggtaaa agtgcctgca gcagaagcac ggggacagga gttcggatcc tcagcatcca 5100
tgttagaaaa taaggtaggt gcagtgctgc atgccccatg catgctccca gtgctgggga 5160
ggcagggaca gcagaatccc aggggtttgt tggcttgcta gctccagggt ccatgagagt 5220
ctgtgcctaa atgataataa ggtagaaagg tgatcaagaa agacatagaa ctttgggcac 5280
acaaagccta cccctcctcc agcaggattg tataacagca gcagaaagaa aggagactta 5340
cagaaagaaa ggagactcct cgaagcccaa ctatttggca tttgtgcaga gagctctagg 5400
gatgtagctt tcaagggtgg acttcttcac gagcagttgt atttgggtta ctcatacttc 5460
tgtaagtaac tgcaagaaat tcatctggac gcaagaagca tcatttcttt gttccgttgg 5520
cagtgcccta tctgaggcaa atagacattt gctgtgtctc tccaggaaaa gtcacacaat 5580
acacagtgag gctgcctggc agaggaatcc tgtttatctt gtggtcaacc agaataaaag 5640
agacaagaaa ggccagagtc tcagtatacc ctagaagaat atttccccag gtaatcaact 5700
tccctccatt aggctgcacc tcttaaagtg tctgctactt ctaaatagta aactggtcac 5760
aaagattaga cacatgtcct ttgggactca cttctgaact gtacccctgg gctatgaatt 5820
ggtcactttc ctgctgttat gacaaaatat caccactcaa gacaatctaa ggaaaaagaa 5880
tttgagcttc cacttttggt gagagagtcc ataaagacag ggaagagatg gcagctggaa 5940
caggaagcta agcctcaatc aagaagctga gaaagtgagc tgggagtagt gaggctatat 6000
aacatttcaa agtgatctgc ctcctccagc aaggttgtac ctcctcatca aacagtacta 6060
cctacttggt cccatcttgg ttgcttttct actgctgtga agatcatgac caaggcagct 6120
tataaaaaag gaagcattta attgatcaat ttataaacac tttatagggg actggaaagg 6180
tggcttagtg gttaagagta ctggctgttc ctcttctaga ggttctgagt tcaattccca 6240
gcaccccatg gcagctcaca accatgtata atgggatctg ataacttctt ttggcctgaa 6300
ggcattcatg aagacagagc cctcatatac attaaataaa ttttatgaac agcttataaa 6360
aacgttataa aacataattt cagagttacc ctatgactac tatggcagga agcatggtgg 6420
tggcaggcag gcatagccat ggagcagtag ctgagtgctt acatcatgcc tgaaagatgt 6480
tgacagagtg agacagggct tttaaaaaca aaaaccacgt tccctgttat gcacctccta 6540
caacagggcc acacctccta atccttcccc aaacagttcc accaattaga gatcaagaat 6600
tcaaacatgc aaatcatgct cattcaaacc accacagagc ctacaaggct ctcattcaaa 6660
gcaccacaag acagcaagac ctatatgaat cagacctgag gtgatggctg tagcttcctg 6720
agaaagggtt tggggaatct ttccaaggag ccagctttgc tctgtccctt acaagtagct 6780
gtctccccag ctctctagga tcttcctaga gattagatta ggatttctcc caaacaaaca 6840
caaaaaaagt ccaaatggag agggttcaaa ctcaacattt aaaaaaagtg agtcacagta 6900
attatgttgg ggctcaaata tctatttctt aggatagaaa tctctcatat ttaaggtctt 6960
tgggaggaga aacatgaaaa atttctggag ttgtcatgca tacacacata cacatacaca 7020
ctatatatat atatgtgtgt gtgtgtatac acatatatac acacacatat atgtatatac 7080
acacatatgt ctatatgtat atatacatac atatatacac acacatatat gtatatacac 7140
acatatgtct atatgtatat atacatacat atatacacac acatatatgt atatacacac 7200
atatctatat gtatatatac atatatacac atataatatt taaatatgtt ttatatattt 7260
atatattata cataaatatg cttaagtatt atctatttaa atatatattt aatatttaaa 7320
acatatatta taccacacgc agtcctctaa ccctccattg gagatgtgcc tgttccgtgt 7380
tagttagcat tctcctactc agtcaccctc tgcttcatcc actgcataat gtcaaatggg 7440
agatctcaca gagaaagaac atgggacagc aagttcattt tcaagatcac atgacagtta 7500
tttccataag tatagacacg tggatttcac atctcgtttc gtccatttgt ttgaatgcag 7560
catacctgta ggacggtgaa aggcagcctg gttcctggtt gagctaaggc tagaaaccct 7620
actgacccta aagggatgct tggagtttgc ctggttctta ggtaccaggc ttcatgcacg 7680
aggccacagc cctccataga tttgtggccg tcagtaacgt aagggcaaca ccgcaagcca 7740
aagccccccc ccccacctgc cacacacaca caggtagagg acgtgaccca tggtcaccta 7800
gcctcaagac acatctctat tttaatgagg tacctaaagg cctggaggac ttagccaata 7860
aactctcctt cccagatgtt ccttcctgca aaaaaggtat ttaacttcag gccctccctg 7920
agaagtgggg tacggtttta ctcagccacc tttcaccatt acaataaatg ccttaaaatc 7980
atggattgct acttttcacc gggatctgct atggagaaga ccttctttgc ctacagagct 8040
accatctaat ttcttgtaga agacctctct gctctcccag ccatggctgc caccaagctc 8100
aagcttgctg ccacagacag ccagagctcc tcttttttcc ccctcagccc tgggctagat 8160
tcagcccgct ggcccccact ctgttctcag gtcttttgtg gctctcagta tgcctgggtg 8220
tccaagagcc cgagaaccag acagctaggg cctccttgta ggccggggga cccccaagcc 8280
agttctggct gtcctgggat ctcagactgt gctttcccat tctggaaggg ttattccatg 8340
gctccccata gaccaacacc agcccggtga cagtgtgggg taagctctgt caaaactcca 8400
gcgttctgtc tccccaagta gctgtgctct gtggtgggca cccctacaca cacccatcca 8460
cagaaacaca gatgagttct tccacttagt ctgagacatc tgaacagcta ctaggttctg 8520
ggctaggggc tagacgtggg gagaatttga tggagcgttg aaactgctga tgaggaaaga 8580
gaagctctct gttcacggct ctgtcctgga catccagagc aaagtataga aatgtactta 8640
tgctataggc tgaataactg agtgaatgca agctcctgac tgcaagaagt tcccaacata 8700
gcaagagaca cgaagagaga cattcttata acaatggtaa gtgatgagaa atatggaaac 8760
agtaattaat tatatccaag cataatggtt acattccata gaagcatttg aagacccaga 8820
caccaaatac aactcaaaga aaagtgatat aaaattttct agtgtaagcc tagtaatttc 8880
aatgataagt tgcatcaaaa gtcaggaact gatcaatgcg attctatcct cttcagagct 8940
ttgaccacga taagaaatag cttgatgcca gcttaacatt agactctaaa gcagtgacct 9000
tcctagtgct gtgacccttt aaaacagttc ctcgtgttag gctgaccccc agccataaaa 9060
ttacttcgct gctaattcat aactgtagtt ttgctactgt tataaatcat aaggtaaata 9120
ttgatatgca accctccaga ggggtcgtga cccccacggg ttgagaacca gtgctctaaa 9180
gtgaactgca ggtgtgctgt gggctctacc acataaacaa ggatgccata gcttttctac 9240
tgttgttgtt ccccgtttcc aggcttatca ttaaccatca tcaggagata cgaggcccag 9300
gcatgtgaca gcttagcaga agacaggcca agtgcaacct tgtgtggagc tcattctctg 9360
agcaaatgtt caaaggctct gggggtgctc attgctcagt ctcactttga agcctgtact 9420
ataggaacag gcattatttc cactctgttg ataaggaatc tgagacatgc attgtgatgg 9480
ccccagtatt atacagctag caaagggtgg agggagccag gaaggacatt tgtagagctg 9540
agtgactcaa ggtcataaaa tggcaagtgg caagtggcaa gtgaggtgac ttgactcata 9600
cctgcctgga accttttgtc ttgactcaac caaactcctc cttattgatt ttttaaaaaa 9660
ggtatctttt taaaaaatgt atgtgcatgt tgcactggct ggttctgtgt ggcttgagtt 9720
atcatagaga aagatgcctc ccttgaagaa atgcctccat gagatccagc tgtaaggcat 9780
tttctcaatt agtgattaag ggtgggaggg cccactgtgg gtggtgccat ccctgggctg 9840
gtagtcctgg attctattag aaagaaaggc aggggagcaa gccagtaagc agcacccttc 9900
catggcatca gctcctgctt cctgacctgc ttgagttcca gtcctgactt cttttgctga 9960
tgaacagtaa tgtggacatg gaagctgaat aaaccctttc ctccccaact tgcttgttgg 10020
tcctgatgtt tgtgcaggaa tagaaaccct gactaagaca aacgtgtctg tacccgcatg 10080
tgtttatgct taccatgtgc ttgcaggagc ccatagagaa cagaagagag cttctcaagc 10140
gatcctcgga aactatgagc tgtctgtggg tgctgaaaac tgaaccccca tcttccataa 10200
gagcaataag cattcttaac taccagacaa tgcctccagc cctttctttt ttttttttat 10260
tacgtatttt cctcaattac atttccaatg ctatcccaaa agtcccccat tcccctaccc 10320
acccatttcc actttttggc cctggcgttc ccctgtactg gggcatataa agtttgcgtg 10380
tccaatgggc ctctctttcc agtgatggcc gactaggaca tcttttgata catatgcagc 10440
tagagtcaag aactccgggg tactggttag tccataatgt tgttgcacct acagggttgc 10500
agatctcttt agctccttgg atactttctc tagctcctcc attgggggcc ctgtgatcca 10560
tccaatagct gactgtgagc atccacttat gtgtttgcta ggccccggca tagtctcaca 10620
agagacagct ataacagggt cctttccgca aacgcttgct agtgtatgca atggtgtcat 10680
cgtttggagg ctaattatgg gatggatccc tggatatggc agtctctaga tggccgatcc 10740
ttttgtctta gctccaaact ttgtctctgt aactccttcc atgggtgatt gtttccaatt 10800
ctaagaaggg acaaagtgtc cacactttgg tctttgttct tcttcagttt catgtgtttt 10860
gcaaattgta tcttatatct caggtatact aagtttctgg gctaatatcc acttatcagt 10920
gagtacatat catttgagtt cttttgtgat tgtgttacct cactcaggat gatgccctcc 10980
aggtccaacc atttgcctag gaatttcata aattcattcc ttttaatagc tgagtagtac 11040
tccattgtgt aaatgtacca cattttttgt atccattcct ctgttgaggg acatctgggt 11100
tctttccagc ctccagccct ttcttaatca ctggactatc tctccaatcc ttccttattg 11160
acatatgttt aaaatgtaaa gtatttttgt tatgtgtgta tgcaaatgaa tgtgctacaa 11220
aaaggatgtg gacaacattg aagaattggt tctttaccca cccaaggatc aatcccaggc 11280
tgtcattgac tgggcttgct ggccacttag taaaaaaaaa tattacattt ggtaggaagg 11340
ctggctatcc tcggtctaat gaacttcctg acccaaccat cccagtgata tattatagac 11400
atacatcacc atgtctgaca ttgatagttg gattattttt tttaattttg aaataagtta 11460
taacacatta agtttaacaa tactataacg ttcacatttt cttttccacc agtttccccc 11520
aagtaagtta gccttagaca taatcaaaac caggagattg acattattat attaccaagc 11580
aaagacggat gctaggtggt tcacgctggt ttcttgcaca cacttttctg atgtatttta 11640
aacatcagat gtactgattc ctgtacccac cactaccatc tggaaatagc actacgaaat 11700
gtccctaagg acactcttgt tcacaattgt accttccctt tcaccaccag acatggcaac 11760
tcttccacac agttgtcact tacagagtct tacatcaatg aaatctgggg tgaatgtgcc 11820
atccaaagaa acacaggaac cagagttggg ttccaggaac ccatgagaaa aagcttgggt 11880
agtagcatac actggtagtt ccagccctgg gaagacagaa acggtgaacc actgagattt 11940
gtagcaagcc aacgctacct tttctcacat ttagccctac ttggtgagcc caggccaatg 12000
agagaatctg tctcaagaag caaggtgcgc gacatgtgag gaagaatact caaggtctcc 12060
tctggtctcc acatacacac atgtacatac ttatgtacac ccacacataa atttgctcct 12120
ccctttggac acatgtccag gagtgtttag aaactggatc acataccatg taacctccag 12180
agactggctt ttttctcatt gatgtgaatg tagcatagtt taggcatcct cacgctgaag 12240
ggcttttgga tcatttttaa ttgaagctat ttacaaataa cactgcaatg accacttaag 12300
aacagtatcg acatggattt ttatttcttt gacaaatatc caggagcagg atcgctggga 12360
gtattagtta cttttataac acaccgcaac aaaatcagct tttgggaggg tttatatggg 12420
gcttataaag gaatgagtcc agcaccatca tggtggggaa gcatgtctgg aggcaggaat 12480
ggtggctaaa cagcagctga gagctcatgt cttgaacaat aaacaagaag cagagaggct 12540
aaatttgaaa tggcacaaat cttgaggtct taaagcccat ccctagtgat gtattcctcc 12600
agcaaggtca cacctactaa gcctccccat acacccatca gttagggacc aagtatttaa 12660
ctgcccagac catgggggat atctcattca aaccactaca ctggataaag gtaagcttaa 12720
tttaaatgag aaatgccccc gacaggctca ggcattgcac acttggtctc caattgtggg 12780
cactatttgg ggaggtttgg gaggtatggt cggtcctgcc ataggaagta tgtcactggg 12840
ggagggcttc gagaatatat aaccccgctc cacttaccat ttgctccctc tctactgctt 12900
gtttgtggtt ggagatgcag tcagtctctt ggttccctgc tcctgccacc atgcctgtcc 12960
cttgcagacg gactcttctc cttccagacc caaaagctaa aaataaactc ttaattccat 13020
aagttgttct tgtcatgata ttttgtcaca acaacaggac aattacaccc ctctctcccc 13080
aaggttatat aaatagtaag gacctctgtg gagacaggat tatttccagt ctgttgtgtt 13140
gtctgcaaat catgtagaga gctcttggga tacacccttc atgagtcatc acctatactc 13200
agggtttttg agtaatgcag tattgtactt gtattgtcca gtgttcctgt cagtaagttc 13260
tcacccataa ttctgtaagt aatccagata aacacattgg cttttgaatg gacactttgg 13320
taggatagtt tctttagtct gtcattggtg ctttatctgg gctgagtaga tgtttgcatg 13380
aagtctacac tctttgtttt ttgtttgttt gtttgtttgt ttcaagacaa ggtttctatg 13440
tatagccctg gctgttctgg aactcacttt atagaccagg ctggcctcga actcagaaat 13500
ccacttgcct ctgcctcccg agtgttggga ttaaaggtgt acgaacacca cgcctggctg 13560
aagtctacac tcttataaaa aaaatagtcc tgttctcact tcatttctgt tgctgtgata 13620
aaacaccttg gccaaacaga acttggggaa gggaaggggt tcattatggc ttacagttcc 13680
aggttctgga cagtcgatga gaaggcaagc ttagtcacct cacacgcata gtaaaggaca 13740
gagaaaaatg aatggatgcc tgctgcctgc tgcctgcttg ctgactgcct gcttctgttt 13800
atcccctgcc ataaaatagt tgagaacctt ctgcatagag aatgttgctg cccacactgg 13860
gctgggtcct cctacatcaa tcaacaatca agacagtctc ccacagacat actcacagga 13920
tctaggcaat ttctcaaccg agactctctt ctcaggtgat tctgggttgt gacaagttga 13980
cagttaaggc taaccatcac agtgtatatt agaacttatt tgttctaata aacttagtaa 14040
ttcccatggg tcattagctc tacctggtag gaactatctt tgtacacttt gttaatacaa 14100
attgactact tgttttaata cctcatataa aatgacagct gtggcatttg tctttctatg 14160
atagagttat ttcacttagc atgtctttaa agtttatctg tgttctcatg tattacagaa 14220
atattcataa tgttaaggct gaataatttt catgtgcatg tgtacagaca catgcacata 14280
ctttctttgc tcatttgtta tgagggatca tacaggttgt ttccttaagt tggctactgt 14340
gaatagagct accatgaaga tggggtgaaa atatctgttt gtgatattta gaatggctct 14400
tttgggtaaa attcttttga atactagatc atgtaagagt ccaattttta attttgaaaa 14460
aatatttatt tttattttgt gtgtatgggt gctttgctag catgcatgta taccacacgt 14520
gtacagtacc tacctgcaga ggtcagaaga gggtgttaga tcccctagaa ctggtgttac 14580
aggctgttac gagctgcttt atggtgctgg caaccaaacg taggtcctct agaagttcag 14640
acagtgctct tagccactga gccatcatct tctggatgta tttttgagaa cctactatac 14700
tcttctgaca tggcatatca ttttacattc tgtcagttgt tcaaaaagct tggagtttcc 14760
ccatatactc attaatactg gtttatcacc atcatcatca tcatcaacaa caacaacaac 14820
aacaacttta ttttataatg gtaattgtga cagatgtaaa gcaatatttc atgttggttt 14880
tgatttgcat ctttcagatg tcagtgacta tatcctcgtg ggtcactcat atgacttcac 14940
tgtagaaata ctttaattat ttaaccccct attcctcccc tctccacttt ttatagtaat 15000
gagggttgaa cccagggcct catacatgcc aggcaagaac attacccctg agttgtatca 15060
gtcagcccta ctcaattttt cagcctcttt taacatcaag atagtaaatg tgttgctgtt 15120
tggaaagttt ggggatttta ttacatcttg ggagttcctt atatactttg ataattaacc 15180
ccttagtggc tggatggttt gtaatatttt tatccttttt cctgagttgt ctcttttttc 15240
tgttaatgtt ttctttcctt atgtgatgct atattggtct gaatgagaag tgttccctgc 15300
aggcctgagc atttgaatgc ttggttcctg tcttagtcag ggtttctatt cctgcacaaa 15360
caccaagaag caagttgggg aggaaagggt ttattcagct tacacttcca cactgctgtt 15420
caccaaagga agtcaggact ggaattcaag caggtcagga agcaggagct tatgcagagg 15480
ccatggaggc atgttactta ctggcttgct tctcctggct tgctcagcct gctctcttat 15540
agaacccaag actaccagcc cagagatggt tccacccaca aggggctttt ccgccttgat 15600
cactaattga gaaaatgccc cacagctgga tctcatggag gcacttcccc gattgaagct 15660
cctttctctg tgataactcc agcctgtgtc aagttgacac acaaaaccag ccagtacagt 15720
tcccagttgg tggtgttttg gggggaggtt tggataccac aagcttgttg gagaaaatgt 15780
atcactggga gtaaactctg agaacagata gtttcccaca tgtctagttc atacctgctg 15840
ctttgtgcct gtggtccgag acatggctct cagatctctg ctcctttcac catgcccgat 15900
tgctgccgta cctcacacca tcatggacac ttatccctct ggaaatcatg aggcaaataa 15960
aatcttcttc ctataaatcg ccttgtactc ggtattttat cacagcaata gaaacggaac 16020
tatgtagatg gggtccctgt tgtctacttt tgcgtctgtt gcctgtgcat ttggtgatgt 16080
atctatgaaa tcgtagccaa gaataaaggc aaagctcttt ccccatctgt tttcttctga 16140
agttttatca tctggggcat atctttaagt ctctaattca tttagagttt gcttctgggc 16200
ataactcttt ttctcaatat ggcagtgttg gggactgaac ccacagtctt gtgcatccct 16260
ggtgagtact acttcattta atgtttagag aagccccgac tattccctaa cctgactctc 16320
cttctcagtc aagtttttat tgatggacgc agctccagtt tgtatcagag aatgaaggtt 16380
agcacagtat ctgttttcat ggaacttctg gtaaaatata catccatagg ccaatataca 16440
tgaaaaacaa ctacacccct gactgccttc accaacctat tgctggtatt ttatttgtga 16500
tagttggagg tagggtgtgt gcctgccact gcatatgcgt agaggccaaa ggacagcttt 16560
gtgagtagtt ctctcttacc tttcttagct tctaggaagt gagctaaggt ctgagggctt 16620
gtgtacaagt attttatttg ctgacgcacc tcaccaccct tcattaccaa catttcaatg 16680
ttccccagct gtatattaaa gggcccaaga agtctataat gcagtaacct gcttaacatc 16740
actgacacag aacttattaa atttgcatga caatgtaaaa catacggatt agtatataat 16800
ttaatttaaa gaaatcttaa tttgcttgct tttataaatg caatttgtta aattgcctca 16860
tggaacagct attttcttca gaggcaaata aaagagacac taatattggt aatcctgctt 16920
cacccaggaa gagcactggt cctagtcagg agtccagcac cgccgtcact gttgggtatg 16980
tctttacatt taagtcaagt tcagagttca gagtaagaga ctatcccaga tgctagggtg 17040
gctttgaggg ttctgagaac ccaaaggtca cgtgaaagat atggttacta ttgtcaggct 17100
gattctaatc agaaatcaga gtctggagat ggagcagata ccattgagaa gcagttagga 17160
ggtggtaatg tggcactgac aacccagcca aggctcaggt agcggtggac atgcgcattt 17220
gctttctctt gtgtttatcg ggcaacaagc ctgggtgaac tggaaagcgg atgcggtctg 17280
aaggtctgca tgaaaccaca gatgtcgatc cgtggggggc agactccggg ggcatgtgtc 17340
tcaggggtat agcacttgga ggtggcaagg actaatttca aggtctcaca ctttaaaagc 17400
ctaaagtcca agcataggtg ggagcccagc ctagactcag agcgcagacg cggacagaga 17460
gcatgctagg agcctctgtt ggacagtcaa acatgaccga gtaagaccga aactccatag 17520
agacagactg agggaaggga gaggttaaag acagggaacc tgggctctaa gatctccctg 17580
taacagctct ccctttgtaa gattggatcg aatccctagg gtaaggggca cagctgagct 17640
tccaggtgag acaagagtag ggagaagaac catcaggtaa gacaatatag ttagagcccc 17700
aaaccaatga accaactaac caaccaacca accaaacaaa caaataaccc aaagaccaaa 17760
aaaaaacccc taaaaatcaa aacccaaacc aaaaaacctc aaaacacaaa acaaaacaaa 17820
aagacccatg agccacagga ggaacacagt tctgtgaacc ctgggctcaa acaagggtat 17880
ggatagaaat taaatgttat atggatggaa ggggacctgg agaaatccca gtgttttctc 17940
ttggatgaag actcttgatc cctgaaacta agtctcacaa gcccagatga agttgtgagt 18000
ttaaatcttg tcaagtgtga aactagagcc aacagtcaaa tgcctccctc caccagctaa 18060
accagtccat tttaacctgt ggattaaatt gtggtttaat tttaggccag aaaaaaattt 18120
ttacttgcca taaatttaag tgctttagat acccatgaca taaagactgg agcattatgt 18180
aaaagggagg cacattagag gtcatttaat gacttgtgcc acttcagagc tttctatcac 18240
atagtccaca gcaattcaaa gtcatgaccc ctagaactaa aaacattacc catcagcctt 18300
tgaactctga aaccggccaa gtgtaataag cccagagcaa agtacagact ttccagtgac 18360
tgagcacagg cagtgactag accagatcgg ccatagtgag accacacact ggccctactc 18420
agcgggcatt cactcagcct agattccatt ttggttgctg ctcacctagt ctcaaaaagt 18480
ctcagctaag tgatgtgaca gccctttgtg ctaggacatg atctgttcta aatatctttc 18540
cacaggtgtg ctgcaaatca ccgtcaacct gataagaaca atccctacaa taaagtgagt 18600
tatttatacc aacatcctcc catgttgttg aaccaatgaa gcaaatgtgg aagaataatg 18660
tttggctcct ttctgttttg aaaacatttt ctgggaaagc aggtgtttgc agactaaata 18720
gatatgcatg ccatgggtga tagatagtct tagatgtcag gtcagttctt catcggggac 18780
agatctttgg aggacactgt aatattggtc atgacagaat agattctgat agaagttggt 18840
gtctaaaatg aaaatggctt ggagaccaca ggtgatcggg gagttcctca tggctgttac 18900
ttataggaag aattcttccc tcctataagc cctgctccat ccagctccca aagatcaacc 18960
agtattaaga ctgacgttgt ttaaagcacc actatctgtc cctgtatcta ctccaacgca 19020
ttgagccagc tatatagcac tttttttccg ttccccaata accctaaatt tcttctactt 19080
cttgttggag atgtttcctt tgccccagat gtctttcatc catccactaa gtacttccat 19140
cccttcctgt actagctaat tctttcctcc cctccaagac tcatcacacc accgtgccct 19200
ccaggatggc ttctctcagt cctcactcat ggactgagag gtgctcccac ctcacttgcc 19260
tggtaggtgc tcccacctca cctctgcatg ccaggagcta agaaaaggaa gttagaacat 19320
tactagagat tcgcttggaa ggaaggcagg aactgagatg gaaagatggg ggggggggga 19380
atgataaacc atatggagcc acatgaaacc tggggttgtg tgcagtaagg ggtgaaaagg 19440
gatctggcta actgggtgtt ctcaacgcaa ggaaagttca taagacaaac ccaaatgaga 19500
ccattaatac tgccaggtac agggcaatgt ctacaacaac gacgatacag aataacccgt 19560
ggcctggaga ggtggctggg tacatagagt gtttgctaag caaacaggag gactggaaac 19620
cagaacttta ggatcatata cattccagat gagcctggca gcccaccaat aataccaata 19680
ctaattaggc agaggcaagg ggagctccag ggcaaggtgg cttgctgaac tagcaaaatc 19740
agcgtgctcc agattcagct ggaaaccctg tttcagtgaa taagatggag gcaataagac 19800
atccagtgcc aatctctctt tcccacatcc acatttgctt ggtcacacag gagtatccac 19860
atccatccac atgcatgcat acacagcccc acacgcatac acatgtggga gaaaaggaaa 19920
aaggaaagaa taaagtaggt agacatgacg tcgagaagca atttaagcag ggtggatgtg 19980
ttttctgtcc atcccttgtg tgtttgtttc tctttcctaa gctccactgt tcattagggg 20040
aaagttcaac tcacataaac ttttcatgtc ttcttcagat atcctcacct tgagatgatg 20100
tagtgagtag ggtcttgtgc acaaatccct cagggtttgg agtggggtat gggtgtcaaa 20160
gggcacaggt gaaacaaacc tggctgtgca ctgattcttg tagggtctag ggttttatgg 20220
ggtgcttcta cttttggggg gacttgacaa ttattcacaa caaaactaca aaacagcgca 20280
tcaggaacta tgggttcttc tcaagtggag ggcattacat attaactgaa tgcgtacaca 20340
tgcctttaag atgggatatg catatgcact gtctaagata ccccgagaag gcactgggta 20400
tttcagatgc tgaacacaga ttttcctaag ctcttgcctt caggccaaat tctgcttttc 20460
ctggactatg gcactgtgca gagaaaaatt atttgagggc aaggtggtga gaagtcttaa 20520
aggccccata gccgaggatg gggtagggct gtctcttctc ctgtgatcac tgaaggcctc 20580
ttatattcaa cagacaccaa atctgagagg tcctaccatg gccaaggcca tatccccttt 20640
cttatgttca gagatggaaa aggaggataa tcaaagtgct taactcacag ggtcattagt 20700
accatgaatg tgttaaggtt tagtccagtg agttgttagc atcgggcatc tgtgctttac 20760
tatcagagtt agtgtttgcg ttggagttag tgttatgggt caatagttac cagttagtca 20820
gacacacact atgatggata ggttgtttat agacagagag aagacatggt tttctgaata 20880
taagacgggg aaggagtacc agggctagga atgagcagag aaactatttg aggatgcagc 20940
tgtgtataat ttaggcaggg tgtgtagggg aggggagaga tgtgaaccag gaagcaaggc 21000
agggctggat ggatgatggt gggcctggca tggggcagca aagttgagac ttgaagcagg 21060
aggccccgag gagccaggga gtgacctggt ccagggaggg gcgagatgaa aacatacttc 21120
aggaggatta ggctggcatg agatataaag tgtctcggtt ttgggcaggt tcagaccaag 21180
ggtcgagaag tccctacaga gctggaaatt tctagacttc ctccagcctc aggctccaag 21240
ctacattttt gccaggctga gtgggaatcc tggagttttc catgggaccc aacaattcat 21300
ctttgtgtct tctgttaccc tcagctttgt ttttgtgttg cgtaacattt ccaggtctca 21360
atatcccaag caagctggag ttttcagagg ttaaactcta gaacctaccc agcctgggtg 21420
gcatctctgg aagcaaaaag agacaccccc cttttgacca gagatccttg tagacaaatg 21480
gccttagctg accctggctg ttctttggtt catataacaa tactcctctc ctctctctag 21540
tccttctccc aacctgttta gacacaagac ttacataaac cttctccact cccctctgct 21600
tcttcaggtg gaaccttgaa gaaaaaaaaa gttgttacta ggccaaggag caaggtttgg 21660
aaagacacga tgtgctgcca aatccaggaa agcaagttaa tgagaaggtg agactctgtc 21720
cacccacttt ctttcattgg cggaattttt aggtaacaaa catagctcca ggcaggtgtc 21780
tgtgccccac tcccatgctg agcaggagct ggacccgagc tgcaggtccc actcagccat 21840
tcagtggctt catctctgca ccatctccag acccctatgt ccaattgcac agcagtgatc 21900
caggtccttc cctctcgaag tccttttgag ctctagcttt ccaggatgcc cttctacggg 21960
tcagtgtgtt ggtctggatg agtcctgggt ctgaccagaa ctactctgaa agggaagata 22020
aagaaagagc cttagaagaa ctagctgtcc taacaacagg agaccccgta ctcacatact 22080
aatgtgcact catgagctca tgtggaagta tacatataag caacactggt gagcacatgc 22140
acacacacac acacacacac acacacacac acacacacac acacacagca tgcatgcatg 22200
cacgtaaaat aaagcttata aaacaaaaca aaacaacacc aagaagcaag caagcaagca 22260
agacctaggg tttttataca tctgttgtgg gattgttgtt gttggtctta ttgtgttttg 22320
catttttggt ttgagacagg ttctcactat ggaaccctgg ctgacctggg gactgcctgc 22380
ctatgcctcc cagagtgctg ggatcaaagg tgtgtgccac ccatgcccag ctgctgtgga 22440
ttttataggt cgttgatggc tgggttttgg ttatgagttt aacactgctg ttgaatgcag 22500
agagcctttt aaatcgagca tcaatgaggg gttgttttgt tactgagggg ctggacatgg 22560
gtttgcttag gactgagatt tgctttctgt tgcctccctt gttctgagcg caattgctta 22620
gctagatgtc gatggccttt caccatgggt ttcctgtgag cgttacaagc tgagattggc 22680
aggtgcattg aggaggtggg caaggggagg ggcgacagca caatgctgtt tccctattgg 22740
tgctaagtgc tgttcctgtt taataagtgc agttttgaac tggaagagag gaggtgtgaa 22800
aacaccacac gagtccccta aaatagcctc ttaacaacca aatcaggagt agaatctggt 22860
ctccgttcag gaaacagggt gcttggatgt ccactcccct ggggctcctt agcccgtctt 22920
tccccttagg ttcaaaggtt cttcataacc tttgggtcca ttgactttac ttctgataat 22980
atcaatgacc tggggacatc caccttacat atgaaggacc cctgtcggca tgagtagttg 23040
tctattaact gtcaccatgt agtcagcttc tctggcagag atgattacaa tctaagtcta 23100
gaatgctggg accctttaat acagtttctc atattgtggt gacccctaat cttttttttt 23160
tttttccgag acagggtttc tctgtatagc cctggctgtc ctggaactca ctttgtagac 23220
caggctggcc tcgaactcag aaatctgcct gcctctgcct ctttgttgtt acttcatacc 23280
tgtaattgtg ctactgttat gaatcataat gtaaatatgt gtgtttttga tagtcttagc 23340
ccctatgaaa gggttccttg aaccccccaa aggggtcgtg ccccacaggt tgagaaccag 23400
ttctctaaag agccatttat gaccccctct ttggctatca ggcttctaaa agaatttccc 23460
taggaatctc cacatgggag aagaaatagc caaaacccca gggacatcca gaggaagacc 23520
taatgttttg tgaagaattt tgcaacttat tagatgactt catagagagt tggcgctgag 23580
acggccgtgg gcagaggcca caccttgtct gaactattca actatgcata tcttttcttt 23640
ttttatgtac cctcacgtat ggaatttgaa atcaaacttg gatgtagtgg tcactgtatt 23700
tcctttgtcc ctctttccat tgtggccact ttgaataaat ctccatttta atttggctct 23760
tttatttggc ttgttcagga taggtggcca aacctggcta gttgggggct caggttgaaa 23820
ccctaatctg gtaatagtaa catatgtcct gagtctggac ctgtacagcc atgctcagta 23880
atgaagaaca agcagcatat tggatctctc ctaaggggtg aatttcaccc ctgctaaata 23940
agcaataatt gatcaaacaa ggactggctg catgcttttt atgctcctca gtattcgggg 24000
gcagcctcct ctttttcact actccaaatt ctcattctga cttgagctta gagttgtgtt 24060
tactccagac tcacgcggtt tcccttgatt attattgtgt gcctctccct ctgaagctga 24120
agaaatagct gatccttacg tgcttgtgga gtaagcaaag aagtcacatg actggatcag 24180
tacaaaaatg tattccgctt tgctgtagtc cagtgaattt gaagccatgg atattttccc 24240
ttttaaatgt acagttcatg tttagagaaa ggaacgcaac gatgtatcaa ttgcttgtat 24300
acttactgtc aaagtagcag aagttaacat ttaggctcag tacttttgaa tttccttctt 24360
tcttgaagaa atggagcatt acattcattt ccatctctac tgagaaaacc agggctgagt 24420
ggccagccat gtgcttgctg tctaaaatgc actgatgggg actggagaga tggctccatg 24480
gtaaagtgtt tgttctgcaa gtatgagatc ttctgtctag acatccagaa caacatctaa 24540
aaatatctag atgtgatggt gccttcctgt aaccccagca ggggtaggaa gggaacaagt 24600
ggatccttgg ggctgtctga tcagccattt caaagaatca gtgagatcca tcatgaatga 24660
gagaacctgc ctcaggaagt aaagggagag gctggagcaa tagctcatgg ttaaaagcac 24720
tggctggttc cagctctagc agcaatctac acggtggttc acaagcctct gtaaccctag 24780
acctaggatg taatgtgccc ttccagtctc caaggatact gcatgcatgc atggtgcaca 24840
gacacacatg caagcaaata cccaggcaca aattaataat aatgatgatg atgatgatga 24900
tgtagataga tagatgatag atgatagata tgtgataaat agataatata gatgacagag 24960
ataaatagat aataggtgat agatagatac ctagatggat agatagagat aatatagtta 25020
gatagatata gctagatata gtatagatag ataaatagat agagatagat aaatagatag 25080
agatagataa atagatatag tattgttcaa tagagataga taatagatag atagatagat 25140
agatagatag atagatagaa tagtatagta tagtatagta tagtatagta tagtatagta 25200
tagtatagta tagctagcta gctagatatg agtgtggtag cacatctggg aggcagaaaa 25260
ggtctgcaag tttgaaggca gcctggatta caaagcaaat tccaaggcta catagtgaga 25320
cattatcttt taaaagtaca tatataaagt aaagcagaag cagaaataag gaaggcactg 25380
cccgttggct tttgtccaca tacacgtaca cactcttact cacatgtgca cacatataac 25440
cagggccata cagaatacac acacacaaag tctaagaatc tagggccaac gagatgtctc 25500
actgggtaag ggcacttgct gctgagcttg atgacctgag gttaagcctt gagaccagct 25560
ctcacagatt ttcctctcat ctctacgtgc atgcaagtgt gtgtgcgcgc acgcaggagt 25620
gtgcatgaga ccagtagagg ggtctttttg tccattgtca tcactgtctt caaatcagcc 25680
atatcaggca cttggaactt gtccctttca tatacttcct tagaaatccc tccgttcaat 25740
gtcacttttc tcatttggac tggttaaaca attccctgga ctgttctcta gaaagacaga 25800
tgtgtgaata attaactcaa cctcattaat cagttgctac cccggtttct aagcttcaaa 25860
gctgagttac ttgcccttag agcatagaat tggtttataa atggtgtatg cattcatgta 25920
tgctaaagga aattatacgt tttatagaac tgagaatatg taaagtatat aaaatgtact 25980
gtgaaaaaaa ttaagaagat agagacgact ttttaagcaa attcaaagag cttaaagtct 26040
tattgtagat agtgttttaa atttttttca cttataatta ttgtgtttgt gtgtgactgt 26100
gtgtgtgtgc atgtgtgtat ctgttcatgt gcatgttcca cagtgtgcat atggaggtca 26160
gagggcaaac tttcagagtt cacgttccac tgtgtactca gaggctcaaa ttcaggtagt 26220
caggcgtgca cagcaagcat ctttctacac cgagggatct tgcaagccca agtgacatca 26280
tatcgatact cttaaaagtc attgccttca agggcaaagg tgatgtcata aaaaagctcg 26340
tgcttaagtc agcttaagtc agagagcagc ctgcagagtt ctgtgctgct gacaccgtgc 26400
tcattgcact aagcctggaa ctatgggaag ctcacagata accaatacac agacagttcc 26460
ctgaagactg tagtcaagga gacgggtgca cacagctaaa cagaccacaa gccagcgaag 26520
cagatgctgt gacagtcact taaaggacat gctgtgggtg agactaggga gctgggagta 26580
ggtgccaata cagcaaaatt ccttgtgctt accaaatggt ccatcctcac tgtcagatgg 26640
caggggcatg caggacacag tggtggtctt tgacttggtt atgaaggatg aaaagacttc 26700
aacaggaaga caaattgggg atgaagatgt aggcagtgga gggaaaggag aagcagtcta 26760
actggggctg aagagataac cagaggacac agtgttggat attttcactg agattaatca 26820
acagttcagt ctttggtcca tcagcccctc ctccacacac acatccccca ctcgtttttt 26880
tgaggtatgg ttcacgtgtt ccaggctagc ctcaaactca ccaagtggtt agctgaagat 26940
gaccttgaac tttagactct cctgcctgta cttccccagg gctgggatga caagtgtgca 27000
ctgccctgcc tcaggtgtgc actgccacgc ctggcttgtg ctgttactag agatggaacc 27060
caaggcttct ggtgttctgg gcaagcacag cctggctcac atccccagcc ctggtccact 27120
cttgtctctt tccacagtga tctatctagt cttggtccca gcaccttgct cagagggagt 27180
ggtcaccgat gacctctccg ctgtttacct ggatggaccc tccttagtcc ctcattcctt 27240
ggcctcttgc tgatgtcact tgtcacgtca accttgatgt cgatggccac actgacattt 27300
gggtcccttg tggtcttcat ctgtaacatc ctgtccaccg ctgtattctc tttgttttgt 27360
tttgttttgt tttgtatttt cgagacaggg tttctctgtg tagccctgcc tgtcctggaa 27420
ctcactctgt agaccaggct ggcctcgaac tcagaaatcc gcctgcctct gcctcccaag 27480
tgctgggatt aaagacgtgc gccaccactc acggcaatat tctcttttat ctatgttcag 27540
atgccttttc tctgtcagtt cttcctcatc ttacatcttt atgagcatgt ctcctgcagt 27600
cttaaggaca tgccctctcc tacaccatgc ctgaattgtt catatctaac tttcaggtct 27660
catcttaatt attactcacc ttaggaacag tttccccaaa ctttgcatct gtccagtaat 27720
gagcctagag ataaaacttt atcagagata aatgcctgag tacccagctg tcttcctaga 27780
ttagcccatg ccattcttta gtttcttttt ttgcataacc cgattataaa tgtaaaagtc 27840
atgtttacca taatattccc agcacttaac acaggctaat caatatcaag ttcttaataa 27900
atattcaatg agtaaatatg ttattcaggc aacatcaaga atgctgggtt gaataagtag 27960
ggttatatag gaagaaacaa gagaagaaat aggctggatg aagaacttta gctttccact 28020
tcaaacattt aaggctattc tacagataaa actgctattt aaagttgtgg tccagtcttc 28080
ctctagtaac atgctttgtt agctggtgta gtgtaaccaa ttagccagtt tagtcaaggg 28140
ttagcagggt agactacacc acaactgtaa gagcagcaag acagaaggac tgaacaggga 28200
tggtgcccaa gagaatgctg ggagttgata gcgaggcaag gccccattcg gcatcctttt 28260
ctgccctgtt atcattcact aggagaaaag agtgcctaag gaaagccaga cttagaagga 28320
agagaggcag agagctcatt tcctgatgca gaatcagccg gcaggatatt agtctatagc 28380
tcaggggctc cctgagcagg agctgtggat ttgagagata tttgggaaga actattagat 28440
gaagatgtga gggttgtcaa ggaaagcaga caaagggaag cgagtcaaga gctaggcatg 28500
tgtatgaact caaatagcaa caacaacaac aacagcaaca aatgccatgt atacatggaa 28560
gagctcgtgg ccgaaatgac aaaggaaaca aatgttttaa actaaattaa agaaatgatc 28620
acgtttagat attgtgctta aaatcttcag gaggtgaaag gtgatctgga agctgacacc 28680
gagcaggggc aaaaagagag catgtcacag ttaggtttag tgggtagaag gtaacatggg 28740
gatgatcaga gaaccactga agtgggggag gggtggtgat atctttgttc ttcagacaca 28800
gaagagcaga aacaaggact caggcatgcg tcgtgacagg gttagaggct tggttaggta 28860
gaaagttagg tttccatgtg tccggggagc ggggaggaga agaatgtgtt cagggcaaag 28920
atccaatgta taaactttta tggccaacag aatgagggct ctcagctaca gaggaaacac 28980
ttaatccgcc tgtaaatttc agtccgtcat actaacctga catggcagct ggcgtcatcg 29040
ggacatgagc aatggttcca agcagagttg attgtgcttc ctcactctaa ttattaacca 29100
gtcactgtgt tagctcattc acgttgagaa gcctcccgcc tcactaccca tctgtatgga 29160
gacttctttt ctacgaaaga agtatgctca ttccaaataa catcaagtgt ccaaatcatt 29220
agtttttact ctttgttttc atatgctatg ggttaagtgc agagctatta aaatacaaaa 29280
aaaaaaaaaa aaaaaatctg gaatgagccc tgacaactga cttgattcca atcttatctg 29340
ccattttctg gctacatcat tgggagactt acttaacctc tcttaggtca aactacatta 29400
ttggatgttt cagcccattc taattttttt tcttttctca gccttttcaa tgtgtattta 29460
ctacttgaac gtttttcatt taaaaaacaa acaaaaaaaa ttgaaaaaac tcccagaaca 29520
tctgctatgt gtcagctact gaaggaacac aatgtttaag acctaggttc ctctcatgag 29580
tcctaagctt gctttagtag gcagtgacag aaggacaaac tggtccatcc atctagataa 29640
acttcggaaa gtgaccgtgt ccatgggaag tcctccttag acactgtgac ccttgagttc 29700
agcctcagag aatggatcca agttaattgt aggtgtggaa ggttgtgttt tgacacaggg 29760
gacaggcaag tgacaagaag gcactgagtt caagggcaca gtatattcta agtgtcagtt 29820
gccagtggct gaacatagag gagggaaaga ggttagagaa gccaagttca aagctcagac 29880
tatgcataca gtataaggtt aaggcactga tcctatagct atgttaccta tgaatgagtg 29940
gtcgttcttg ggcaagggac ataactcaat aggtttttcg cttttccagc tgtaaagtgg 30000
aattgaaaat ggtatggcat agcgacctca catagaagta ttcaaaacaa tgtctagggc 30060
acggttatgg ttatggaagc ctcttgaagg gctccagcaa gtagagattt gagttgcagg 30120
cagaggcaag cgaagagtgg attggagagc cgtggaaacg ggagtggaaa gatgttagaa 30180
aaaaaataca gcctgcactc aggagagggt atggagatac aggtgaagca gacggctggt 30240
gtcagtcttg acagcccatc aggtgaagat aggatgagcg gtaactaata cccagagttc 30300
tacttcgaac acatagtttt ctgtttgtac cctaactaca tgcacgcgcg cgcacgcatg 30360
cgcgcacgcg cacacacaca cacacacaca cacacacaca cagatacata cacagacaga 30420
cagacacaca taaacagaca cacacacaca cacacacaca gagagagaga gagagagaga 30480
gagagagaga aatgactata tcataggctt tggggcaggg acaggtgggc ctaggtacag 30540
agtcctaact tttatcttgc tttctctctt tctttctttc tttctttctt cctttctttc 30600
tctctctctc tctctctctc tcccttcctt ccttccttcc ttcctccttc ctcccttcct 30660
ttcttctttc tttctttctt ctttttcttt tttctttttt cttttttttt cttttctttt 30720
tgttttttcg tttttttggt ttttttgaga cagggtttct ctgtgtagcc ctggctgtcc 30780
tggaactcac tctgtagacc aggctggcct taaactcaga aatccgcctg cctctgcctc 30840
ccaagtgttg ggattaaaga cgtgcgccac cactgcctgg tctactttta ttgatttttt 30900
gatattttcc ttccctcaca aagaagttga caaacagcct ggcagagctg tgagaactga 30960
atggagactg agtaggaacc gtgccctgga tggtgcttgg ctctcatacc tcagatcctc 31020
agggaaatgg gctggactgg ggcctagagc actgaatccc ctggaaggcc cctgttgaca 31080
aaatctctcc ccaaacccga caaaagcatc acaaactgtg ttcttcccag cacctacagg 31140
agctacacct tagaacacgg atgtttccca ggtgttcttt tactgtccta tttctaggaa 31200
cccgggactc gcacttgttt gaactctagg gcgtttaaga agtcactgat aaggcagagc 31260
cagatggagg tgggatgagc aagaactgct actctgaaga gagggacagg tgcacagaag 31320
actaatggct cagtagacag aaaacccacc tctatctaca gataagccag gtgacaacat 31380
tagcctcctc ggcagctgtc ccctcttctg ctgagaccta tcgattgaca tcctaaatgt 31440
cactgtgaaa tgttcaaggg atactcccca cttagcgtag ctgctgagcc agggaaggca 31500
actgaatgtc ttatttgaat gggttgcctg gtgctctcca gaaaggttcc aggctgggac 31560
ggaaccttcc caagtgaaga aactcacttc acaagcctcc agtccccgcc ctgcaacaag 31620
cctgtttgtt aacttgaact tgcggtgaca cacaccgagt tcatttccag tttgcgctcc 31680
agggcaagtc cttgactaca caaagagtga gacagttggg gaatttgtgg actgtccagt 31740
taatcagata aaacccgaga gagtcagaaa ggcgacttct tggaagatgt caaagtttta 31800
ctgaaaacag cggaagtgtt cgcagctaat tggtgctttc cttccacaca ccccgcactc 31860
cctaccgccc cctccctccc cgcctcccat ccctgtccag tccccacccc ctgaagtttg 31920
tctttggtaa accccagcta cttctctcac ttgtctctga ggcacaatgg gagtcttcat 31980
ctgaattcta gggaagaaaa gatatgactc cttctagcac gagtgagctg gattgtaaca 32040
gggaacgaat tgattgattt ttccccccct tcatctcaat gaacacacta tgtagccaaa 32100
ccaaggctga tcaacaacac tcaataaaaa aggagattca aactgaggcc cagctgagcc 32160
ctactagacc tccacaatgc acgctgtcat ctgcttctta catgtcatca catttaatta 32220
tattaatctt cgccataagt aatggagggg attattatga gccttggtct agcaactggg 32280
ttcaaggtca cttagctaat atgtaactct aaatgttaca agtttctaag ccaaggatat 32340
gtccttttct caggccgatg ctgtcctgct ggccttctaa aatgttagtt ctctgcctct 32400
tgttctgtgc ctacctcagt gccccacccc cactcctgct cccccccccc ccattattct 32460
gatcacattt acattcccgg tctcccattc tcctgatcct gtgtgcttac atcagctaga 32520
aattatatgc aggactttta aagagttttt ttcatagtat tgcctttttg catatatata 32580
tagtgttctt tgtttgtttg tttgtttgtt tgttttcaaa acagggtttc tctgtataat 32640
agctttgact gtcctggaac ttactacaga ccagtctggc cttgaactca cagacatcct 32700
cctgcctctg cctgacctgt caagtcctgg gattaaagct tgcaccacca cacccagctg 32760
cttttatagt tttttttttt tttaagttgt gtggtgtgca tgttgttgtg ttttataaaa 32820
tagctgtggt ataatgtttg gggatgggga acatttcagc aggcctctgc caaggcatac 32880
cccttgagga atcagtcata ccacaggctt agtataaaag ggatagggga cctggaaaag 32940
gggcagaggc agagaaggtg ggggacagag gaggacagaa agagagagag gccagctggg 33000
aacatgttgg ggagagatag agagagggag gaagggaagg agaaaagaga agagagagag 33060
ggggagggag agggaggagg agatgaagag gaagggaggg aggagagaga gagagagaga 33120
gagagagaga gagagagaga gagagagaga gagagggagg gagggcaagc agtccttttt 33180
atacaccagg ttggctcaca cttggcaagc ctcaagctgt tgctaggaag ctgttggatg 33240
gagcctaaag gaactgccaa tagtgtgtgt acagatgagt ttgtgtgtgc gagtctatgt 33300
gtaagcatgc agaggccaaa gatatcgttc tatatgacag ggcctctcac tgagcttgaa 33360
gctagtcatt ttccccaggc tggctggcca gcaagctttt ggaatctgcc tgtctctgtc 33420
ctccaaagat gtggttacag ggatacatgg tagtgcctgg caatgcctgg ctttttatga 33480
ggatttgaag tcaggtcccc ctgcttgcat agtaaatgct cttacccact gagccatcac 33540
ctcagactca tcttattaat tgtttcagtg tcgctgtatc gtggacacaa acatatgcat 33600
gtatataata gggggagagc agattattct ggcatttcga gatcctagcc cagtgcaggt 33660
gggtggcagt attagcaaaa tcactctgat ctgatatctg tttattcatg tattcttatc 33720
taagtgttgg aagaagaaat ggcacgagaa agcacagtaa cttagttcac agtcacaaag 33780
cttggcaact cctagctggg tggtgacacg ggctgtaccc ctatcattca ggaggctcaa 33840
gcagaaggct cccgagatgg gagctagcct gggcgttgga gtaaatccca gggtaacttt 33900
ggcttgtgta gtgagttctt gttttgagag actcacgtct ggggagccag agcagtagct 33960
cagtggttaa atgtactttc tgtgaaatca taaagatggg agttcaaatc ccagaacctg 34020
tgtactgaca tactggggaa aacctataag gccagctctg gagggaggtg gaggcaggag 34080
gattgctgga gttagttggt gtcttagtca gggtttctat tcctgcacaa acatcatgac 34140
caagaagcaa gttagggagg aaagggttta ttcggcttac acttccatac tgctgttcat 34200
caccaaggaa gtcaggactg gaactcaagc aggtcaggaa gcaggagctg atgcagaggc 34260
catggaggaa tgttctttac tggcttgcct cacctggctt gctcagcctg ctttcttata 34320
gaaccaagac taccagccct gagatggtcc cacccacaag gggcctttcc cccttgatca 34380
ctaattgaga aaatgcctta cagttggatc tcatggaggc atttcctcaa ctgaagctcc 34440
tttctctgtg ataactccag ctgtgtcaag ttgacacaaa actagccagt acagttggct 34500
tccagcgcag acaggaaaat ttgaatcttg attcagaatg agatccgtcc tcaaatgaaa 34560
agccagaaag taacagagga ggacactcaa tgccctcagt gggcacgcgc acaggtttgt 34620
gtatgtgcac agaagatggt atactattac catacttgtt tgtttgtttg tttgtttgtt 34680
tgtttgagac atggcttctc tgtatagctc tgggtatgct ggaccaggct gacctcaaac 34740
ttacagagat ctgcctgcct ctgcttccag agtgttgggg ttaaaggagt atgccaccac 34800
cccctgtgga cacagatgta ttcacaaatt ttcaaattgc atctgtttgt ttggctagtg 34860
cacctggcac agagcgtcct ccacatggca tggatgaaga cttattccaa ttggttattg 34920
atcaaactaa ttcatgaaaa agacagctgt ctttcacctg cccagacaag gagcaaaaat 34980
tcatccttat cttatggatt gtgcaccttg cacaatccat acaaatattt tttataggaa 35040
taaagatttg gttgtaagat tcatatatta cagaatgaaa cagggagata cagctctgac 35100
aagattcatc cttggggatg ctgagatgac ccgctgtccc agctcgctgc cacatcctgc 35160
ctcacctgat gctgtttcca gagacctgct tccagagcag cgtcaggggt ggctgctgat 35220
tcccatgaca tcagttcatc cagcctttca gacagatcca ccaagacttc agttaagccc 35280
tgaacattct aagcatacag ggactggata acaaatgcga aaactagctt tcttaactct 35340
aaccaagttt tcttatttcc ctacacctcc cacccccttg aaaaaaattc atcaccccaa 35400
ttcagcagga agtagttatg gagagttgtc atcttgattc cttgggttta ggtgtctggc 35460
tatggttatt ttaacattat tatagatatt ttaattattt aattattatt aaattataga 35520
tattttaaca tattaaggga tactttggaa atgatcataa ttttagacag ggaggaaact 35580
agagaggtta gacttggaga ttctgtcttt ttttttttct ttcctttgct ctagccttac 35640
tttcttaggt aaaaggaagg gagctgaaat gaaaatgggg actagagtaa tataggaaat 35700
tagagatgtg agatggatta ttcaatttac tcttaaacaa aacattttat agttataatc 35760
tttcattggt agaaatcttt acattttgat gcagaactaa agttatattt tcttacattg 35820
gtacagaatt tatatatcga tacaggttta aggttttcac tggtataaat ctttgtatat 35880
tgatataaaa tttaaaatta attctgttac tcttagacag gcattgtgcc tatacaactc 35940
atttatacaa tacaaggctt agacccagtc cttctaatag gtactgtcac aaatggttta 36000
agatgattaa gtgatgcaag ttaatggtca gatagtaaac tcatgctcat attagattct 36060
gatttaatta caataaagtg ttttcaagat tatcacgtag gaaataacta agagtaatca 36120
atgtttaaca attcaattat attacatata gatagatggt cttcaaaaac atcagaggtc 36180
cacaaaatat ggcatttaaa atcatttcac tattaatagg tcttttgact aggagacatg 36240
tctgctccta acagtacccc catctcactg caaagaaggt actgagtatc aatacctccc 36300
aattggagtt gctttgattg cgatgagcta gctgctggta agaaatagcc taatttaatt 36360
ctacagacaa ttactgtcca gaaaggacaa atggatgcag gacagttgac tgctaagctc 36420
tgccaaaaca gagtaagcta gtcctttata tttcctgctt catttatggt ctatcagatc 36480
gttctggacc agaagtctga agacaggtgc tccaacatta taaggaatat tgaggactgt 36540
ccaggcagtc agttgttcct acaaattgta ttaagtttta gaagctatgt ctttgtgctt 36600
tctacatatt ctgataattt taaattcctt ctcagatctc tgatggaatt gaaaaatagt 36660
tatagtctca taattgaact taagttattt agcactaaag aagatgttct agatttgaaa 36720
ggatggtttt ctgagggtat tgcaagttaa aatcaagcat aattgaggta cagatttgta 36780
aattctgtaa gttaagatag ataatagagt actttatcta aattgtcaga tatgatgtac 36840
tggatgttct aagtgtatat cataccttac aatttacata cttgttataa ctgtgttcaa 36900
tgtatatttg ggagaaaaga gtttttaatt ggacaaaagg ggggaaatgt agctgtctaa 36960
tgctaattat gtttcctcat aactatttgc atgagagggt ctgcacatag cttctgggaa 37020
ccttcccaca gttaattctg attggtaaat aaagttccca gcagccaatc tctggggaga 37080
agaaaaagag gtgggtgggg cttaggtttc ccaggtgtgg gacctctggg aagagagaag 37140
gaagagagac tcaatgcctg aaaggtagta taggacaaag aggcagagcc accctgtaaa 37200
ggggccagga gagagtggcc cagatggctg ctcaattggg ccaggagagg ccaagatgga 37260
acatagaaat tggtaagtag taacttggaa ttattggcgg gaggtagagt ctagcagtat 37320
ggaggctagg cagatgccca gctattgtgc tgcttaagtc atattaaaat ataaaggctg 37380
tgtgtgagtt tttcattaga gatcataaac cattgaggta ggaagtaatg ctgtgctggg 37440
atttattaaa acattaatac tacacttgtg gcaatcacag gacagacaac ttgtaggaat 37500
ggattttctc cttccaccat gtgggtctag ggaattgaat ttaggtagtt tacagccttg 37560
gtggcaagca tgttcaagcc agccccaatt taatgatttt aattaaagtt gttgtcctct 37620
gaggcacaaa aaaaccccaa agggttcaac acaatcagga ttcctgctgg cctctcatct 37680
acagcttggg ccagaagcct tgctctgttt tgcatttgga atattttatc tcagtctctg 37740
taagtcaggc ccagggatgg gtatagtcag tacacatgaa tttggtctgc ataactggaa 37800
atgtgattat agcttctcag ctgttccaaa ggagaagcac catcatatcc cattctgcct 37860
ttgtgtgaaa aactcctcaa aaatacatat tagtttgtat ctcatatata tgtatacata 37920
tacacatgta tgtatgtata tatgcatgta tgtatgtata tatgcatgta tgtatgtata 37980
tatgcatgta tatatgtata tatgatgtat atataatgta tatatgatgt atatatatca 38040
cagacacata taatttaggt cactttttgt ccctatgttt tatttctttc aaaacctact 38100
gctgcgcctt acacagtgtt ttgagaccat cttctttctt atcttttttt tctcacataa 38160
tatatcctaa ttacaatctc cactccttct agtcctgcta gttcctcccc tcctatccag 38220
agccaccttt ctgtctctaa ttagaaaaca agcttctatt atatagatta taataagaca 38280
aaacaacacc taacacaact gaataggaca aacaaaaagg cagaaagaaa agagaagtca 38340
caagaaatag atccacctgt tcacacactg aggaattcca tataaactct aagctggaaa 38400
ccataatata atgtgcgaag gacctttagg gtaaagagag agaataaaac tgcataaata 38460
aaataaagta aaaataataa taaaggaaaa tccctgacac agcacagtaa gacagggaag 38520
ctccaaagac tctgttgagt tcattctctg ctgaccatct agttctggac atgtaaccta 38580
cccttaagag tcgtttgttt ccacagcaag actgtcttag aggaaactaa attttcattt 38640
ggaaatggtt atcaactgga attgcttctg ggttaggcct aggggcttgt gtctacatct 38700
tctctcagct ctagggtcca atcttgtcca gacctgtgca ggtccatgca tgctgcctca 38760
gtctctgagt tcatatgtgt atctatcggc ccttgttttc ttggtgtgcc ccatcccttc 38820
ttgctcttgt attttgcctc cttttccctg agccccaaag gaagggatct gatggagata 38880
gcccatttag ggcagagtgc tttaaggtct ctcatttctt acaaatatct gtctgtgagt 38940
ctctgtgttc ccatctgcta agggaggaag cttctctgat gatggctgac aagacgccaa 39000
tcaatgagca tgtcatcagg ggtcatttta tcgttacatt tttgtttgct taaaaatagt 39060
aatatttggt tctaccctag gttcctgaac tagcttgtct caggttcttg gttacccaag 39120
cagtgtcagg tttcatctaa tggagaggac cttaaatcaa atcagatatt agttggttac 39180
taccataaga tttgtgacac cattgcccta gtgtattttg caggcagggc atcattgtag 39240
atcaaagagt ttgtggctgg gttggggttt acctctctcc tttggtagtg tgccttccca 39300
taccaagaac tctggtagat aaaggtgaag gctctatgta ggcaccagct caatttctcc 39360
acgttcaatg ggttgtgtag gtgttgtctt cagcaatttt tagggtcact tatatatact 39420
atcatatcat ctgcaaataa acacactttt tcttctttgt ttccaatttg tatcccattg 39480
attttcttta gatgtcttat tgctctagct agaacttcaa gtgctatatt gaaaaggtat 39540
ggagagagta gacaaccttg ttttgttact gctttttagt ggaattgctt tgggtttctt 39600
tccatttaag ttgatgtggt cttgctgtaa gctaccttta ttatgttgat ttatccctaa 39660
ttattccagg acttttatta tgaaggagtg ttgggtttta acaaatgcct tttctgcttc 39720
taatgagatg acatgtggtt ttgtctttca gtctgttaat acgatggatt acatttactg 39780
attttcatat ccctgcatct ctgagatggt gcctacttga tcacagtgta ttatcttttt 39840
gatgtgctct tggattcatt tgcaagtatt ttattgacaa tttttgcatc tatgttctgt 39900
ttgaatttgg tctgtagttt tctttccttg ttgagtcttt atgtggtttg agtatcaggg 39960
tcactgtgac ctcataaaac aaattgggca gtgtcccttc tatttctact ttgtagaata 40020
atttgaggaa tattggcatt aactcttctt tgaaagtctg gtagaattct tcactaaaac 40080
catctggccc tgggatattt tttttttttt tttttttttt tttggttagg agacttttaa 40140
tgactgcttc tatttcacta ggggctatag gtctctttaa attacttagc tggtcttgat 40200
tcaactatca taagtggtat gtatagagaa atctatgtga gctgaagaga tggctcagca 40260
gttaagagtt tgctgttcct ctgtaagacc tgaatttggt tcttagaacc cagattgggt 40320
aactgatagc tgtctgcaac tgcagttcca agagatataa tactctctct tctagacact 40380
ggacatggca cacacacaca cacacaaagt tgaatgcaaa ttaaatggta gataacggta 40440
tgtgcacttc agagtttgtg gtaagtgaca gttgatttac ttgatgcaac acagagtcgt 40500
ctggaaagca aatcttgtgc aaggatcgcc taggttaggc tggctatggg caaggctgtg 40560
gggaattgta ttagttggtt acttgtggta agacctatcc tgattatggg tggcaccacc 40620
tcatagtctc agtcctgggc tgactgaaaa ggagtaagct gagccctggc atgtaagtat 40680
taattcttgg ctctctgctc ttgactatgg atatgatctg actatctgtg ttaagttcct 40740
gctgtcccca ctgcccagga gtgatggccc tagcctgcaa ctgtgagcca cagaaatccc 40800
ttttctctta agttgctttt atttcggggt tgggtggtgg gcggtgagac cgaggttttg 40860
tttttgtttt tgtttttgtt tttgttttgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 40920
gtgtgtgtgt gtgtgtgtcc gtgtgtgtgt cctggctttc ctagaactca ttctgtagac 40980
caggctgacc tcaaattcag agatgggttc ctttgaggca agcaacttct gaaggctagg 41040
aaggctcaag cacattggct cctgggtcca cagtgctcag catctgtatt tcatgaacag 41100
ttcctgggtc ctctgccagg gctgtaagaa gcacggtgtc tgcttaatac aactgcagcc 41160
aaagaagaca gaggtgttgg tgcaaaaaca cagctctcac atcaaagcag gtaatagttt 41220
attctgaagc caaatatgag tcccaatggc ctagtaatac agatttaagt tacccagcat 41280
tctgtgtcca atgtgctaag atttggtaaa gtttttatgg aagcagaaga agtttattac 41340
aaatccgggt acttttcaaa cacattggtg gaggcatcgg gtaggtggat cacagcaaag 41400
caggaacaac tttacttgag gctcagatgc tgacagtgtt tcacagccca ttggttggcc 41460
ggaaactaag agttcgcaca ttctacggaa tttacctaat ggcacatgga agggcaataa 41520
atggctgttt aggatcctaa agatgcccca agataatttg gctctagact tgcaacattc 41580
taacccctct acatcattga cattctaatc agttccgtca gcctttccag ggctgggggg 41640
taggggagga aggcaaggct atttgaggaa tagcttcact acttgaacac cacacattca 41700
gggctgcaaa ggacacacaa ggctctggtc tgtggttact agacctctca tcaattcatg 41760
aggttgtagc tatttcgaac tctggaccat cttgtagagg aatgtgaatg aggctgaatt 41820
tccgacatgc ctttggacag atgttcgtga tgctaactct agtttttgta agatagttat 41880
tctcttctgt gaagtgatga agaatttgac acagttttaa agaatctccg tctctctgac 41940
tccgtctctg tctcaatctc tctctctctc tcttcaaatt agaggtttgg taatttaggc 42000
acagggctgc tatatgactc tttgatagcc tcacaggcat gtgtacttag tgtgatgctc 42060
agcactttga aggaaggaag gagggaggaa gggagggagg gaggagagag aaaggtgaaa 42120
ggagggatga aggagggagg aaagaggaaa ggaggaagca aggaactcag ttataggcca 42180
aagagttttc aggtttatag acacatagat ggttgcagct gtagcctggc agtctacata 42240
aaggacacat aaagacattc tcttggccac aggttgctaa ggctgggtag gaagtctgta 42300
gaaggaagcc agaagtcagt aagtcacaga ttaaacattg agcaaaggac cacatcatta 42360
gtcactcaat gctagtgttt atttgtcttt ctcttttgtt tgtataaatg gaagtactct 42420
ctagggtttc tgtttaatta aaaatcttat taaatataag caatgaaact ggcttaacca 42480
ggaaactgaa cattaaaccc gttcacaaaa cgtatgatct gactaggaga aagagaaatg 42540
tgctacccac accaatcctg gttggacatg tgcctaagcc gaggtcacta ctagattcag 42600
tcagtaccca gagaaggtag caaacagcct ttgccatata actgaatgaa gggccagcct 42660
catatctggg tttctaactg cagaacacat acatgggtgt gtatcccagg tcaggttgtg 42720
ggtggcaagg ccttgctgct gtataggggt cagggctctt cttgcatatc tgtgtttata 42780
acaagagttg cttctgggtg gcacagacta ggggagacag ctcctccttc tagtatcttt 42840
gtcaagggaa cacactataa ccttccatgg tggttagctt aactatttcc tgtgggtgtg 42900
tcccttatta aaactatatc ctaaatatgg tcctctctta ggaggcatcc catttcctag 42960
tcagtcatca tacatgatat acaaagagag gtatcagggc ctgggctcca tggctgtcta 43020
gatgtttctc atctgttgtg ggggatggtg cagcatgccc tgagctgcct gagtcactgc 43080
aggaatgagg aagactcaca gggaggaggg accaatttcc ttcttcagta gagtcagaga 43140
gctgcatagg tgagatctga gctgtgcaag gagtgggcag ggcttagatg tagaaaattt 43200
ttaatcctga cctggggctt ctaccctgcc tttgactctt tagttcccag atagaagaca 43260
cacacagcct ttataattac aataaacctt caacagcaca agagctgggt ggatacttac 43320
cctctacgtt attagaatct actttcctat tgataactct gaattattac ttactactta 43380
actatgtttc atctgggctg ctcttaactc caattggcca gccctcaggg ccatgttttt 43440
atgattccca aaccatggca ccttctcctt tgtcttctgt accttctagt tctccttggt 43500
tctcctctga cccatgaggt caccccaaac ctctaatccc tccagtaatt ggctgtagag 43560
aattttattt aaccagtagc tttaaatcaa gggacaaggt ttgcagaaca caagcttgta 43620
aacaggagaa gtcttttgta ggccaagacc tttggctata gaatttagca ttacaatgca 43680
tagcatcaga ccaaacctca acacttagaa actcagcaag ggacaatgtg ggcaaagacg 43740
tggagtgaga gccccctcag ggaccccatg gtcacctgtt ccccattaac cacaggtctt 43800
tgggattctg caaaccccca gcaaccccca gcagctgctg gaagcaccat cccatactcc 43860
atgagtgtgt atccaagctt tgcaattctg aagtcctatg agacaatgtg agtagtgtgt 43920
cattgtcagg attcatgtat attgtagaca caagatttaa tgaaatcttt ctattgtcaa 43980
aagtgtttct aaaatgtttg gaattacatt agagcagaaa gagctccaat ttatgttttg 44040
ctaggtacct tcccaactta gtagctttat ttatttattt atttatttat ttattatttt 44100
tgatcatgtg caggctccca aagtgcatgt ggaagatcaa aggacagatt tgtggagtca 44160
tttctcatat tctaccttat gtgggctcca gagctcatac ttaagttgtt aggaatgtga 44220
ggaaagtgct ctacccattg atctatcctg ctgacccttt agccatttta aatagcaacc 44280
atttctgaca gcatttggca tctgaagatc aagaattcag gggctcctta gctgtgtggg 44340
tctggcccca ggctctcaaa aggcagtgag cacatcttgg ccaaggttat gtcacttgct 44400
gttgaaagat caaattcttt gggttcagac tccatcttag acaaacttga cttaagtaaa 44460
ttaacaggtc ggtacctagc tccagtttcc agattaccca aaacaaaacc tgagcttagc 44520
tccagtttcc aggctacccc taacaagatc tggatctcca gtttattctc ctctaacaaa 44580
tccactgtct agcaccaatt tccaggttaa tccccagcaa atcccaacac ctccaggtta 44640
caaggccgcc cctgcctaac aaccaccaat taggaggaaa gccaacgttt ggctcccagc 44700
accagccaat tacaccaaag gtcacagtag caccccaatt agatgcttgc taggcttgaa 44760
acactcaccc ttcacttgtg atttcctata aaaccttgtc ccagtgagtg atcaaggaat 44820
ttttccatgg aaccgtcctg tgggtcagca gtgaatcaag acccacgctc gagcttgtga 44880
ataaagtccc tggtgtgata gcatcggatc cggctccttg gtggtctttt ggagttcatg 44940
aacatttcag catgatactg tttaactggc atgggcattc ttcttgtggt gggcatctgt 45000
tcttcaaatg gcgcatctct gtgtgagtga gtgtctctat ggcatggtgg ttggtcgcca 45060
ctgaaatgac ttttgtagaa gagcaaacag ataaaaggtt cttttgtgcc gtagtctctg 45120
tcaaaccatc acttctgctg tattttatcg gccaccctga gcatccttga tttgatgcag 45180
aagaggatta tgcaagcaaa taaataccag aggatgtgta ccactgggaa acaaggcaag 45240
gtcacctctg aattcatatt ctgggaagat tagagctttc agaacaggag ctgggcacat 45300
gcctgtaagc tccacactca gaaggccgag cagatggttc acaccagtct cagttacaca 45360
agtcagttaa ggtcaacctg ggctacttga caccctgtcc ctacaacaac caaatataca 45420
cgcatgccag agatgatata gtgaactaga caccctaaaa aaatttcacc tttaacgtat 45480
tgaaaaatac tgagtagaac attttaaaga tttattttgg tttttaaatg ttatgtctgt 45540
gtatatgtgt ctgagtgtat atcgcatgag tgtatatcgc atgtgtctga gtgtatatcg 45600
catgcatgaa atacccacag aggacagaca atgtcgccag aactctaaaa ctggcgttac 45660
agacacctgt gatccaccac gtgggtgctg ggagcccaat cctgatcctc tgcaggagca 45720
acacaagctc ttagtcactg agccatctct ctagccctaa gagtcaacaa ataaacacac 45780
acacacacac acacacacac acacacacac acttaaatct ttaaaagctg ccccattata 45840
ctatcaggag aataacaggt aaaaccaaca caggaggagg tgtggattga gagactcgcg 45900
gagttgcagg ctctccttct cctgctctag ttcccagtag cttactattc atttaacaat 45960
gtttatggcc gtttgctagg cctattcctc atctaactcc taacttactt aacctgttta 46020
aactattcta tgtctgccac atggctggtt acttctcagt atcatatatc taatttcctc 46080
agagtgcagg tggtgaacct cccagagttt cagtctgtct actggaactc ccagtttcta 46140
cttcctgcct ttggcaaaaa acaccatgcg gcatatttgg ttttacccct tgacctagaa 46200
aacctcaagt gtttatttcc tggcccttta ttttctaaaa tgccaataag ataggccacc 46260
agatctttaa tgacaggtga tgcttcgaca cagtacctga gagattatct ctacagacat 46320
aagtgcttaa gctgggggct cctctaggca catccctcaa ccaccaagtg acagggaagc 46380
ttggtgagtt tctttcacat ggcaacaaac aaggcacctc agctagcaag caggaaagca 46440
ggagataaca tgtgacggat gtaggcgtca gagcaaagac ccttccagaa actgcctcaa 46500
atctcaatgg atatttctca gtgatagttc acatcaggct tttttttttt ttatgagtac 46560
tatttttctt ggtttattca ataggctgct tcaatttacc ttaatgtcca cttatactta 46620
tatataagct tcttttatac aagctcagtg gactcactga gaaagcacaa ctaggaatgc 46680
aaatcagaca gcaatattaa tacagagttc accttctcct ttcaatggaa taaataatgc 46740
gtgcatttgt ctctttctaa atatttaggc accaaaagtt ttcatgggac tctttctttt 46800
ttattttatt tacttattag gtattttctt catttacatt tcaaatgcta tccccaaagt 46860
cccccatacc ctcccccctc ccactcccct atctacccac tcccacttct tggccctggc 46920
gttcccctat attggggcat ataaagtttg caagaccaag gggcctctct tcccaatgat 46980
ggccgactag gccatcttct gctacaaatg cagctagaga cacgagctct gggggtactg 47040
gttagttcat attgttgttc tacacatcag gcatttctta attctctttc cacatgcaag 47100
gagataaaac ctttcctact tctacagtag ctctgatggt cagggaaagt caggaattat 47160
aagcagagtc tgggtttata tgggcttgca gccacgctca cccagcatga gttacagaaa 47220
cctggctgat agtctgtttg gaaatgtgac ccagcatgag aagtgttctc tgtctagaaa 47280
caaacgggag tcctgttgaa gcacatgatg tctttggttt tgccccttcg tttagaaagc 47340
ctaaaaagat tattatctgg ccctttattt atttttaaat aaatgtcaat gttagttgca 47400
gaaatacctg catagaagcc cccagttagc ctagagttga aatacaggaa agatgcattt 47460
atcaaactac cctgtgcagc agaacaaact gaattagaga ccggggcagg aggaagcttg 47520
gttagacaca gtcttaggct tggttaaaaa aagggggggg gggcgttatg cattatgtac 47580
agttaactgg gtacctgaaa tagaccagac ttgcttctga gcactgaggg cttaatggtt 47640
aactataagg agcctaggga ggaagattgg ttcgagaaca tagttactcc tcaattgtga 47700
atggagttct gcaaacagag aacattaaga ggaacagaaa aggagaattc ttttggaata 47760
atagctctct gccacatgta cccaggtgct ctgatcccca aatacatcaa agctgctttg 47820
tcacccagtc tgtgccagaa tgggcttgca caatgcatct gagcaccgag tgctaatatg 47880
ctctcctgag agcagcagtg gggagagtct gagctggtgg cagtgagcta gctgcagatt 47940
gctctgggct ggtggcagca ggacaagtca attaggggag tgattgggag aaaggaaggc 48000
aagaggcacc cagagcctcc aggctcttgt ttgaaaaatg gaagacacac ctggcttttt 48060
ccacatttcc ctaggtgctc gctagggcct ggtcacctgc tctcctgatt gactcagcag 48120
ggattgggtt gtaaaattag gggctgggtg atgaggcagc aacttccgag tgcctattct 48180
gtgcatgtct ttgtacattt atcaaggccc tcaaatcacc ctcacagagc agatattggc 48240
cccttgtttt gcaaataggg ataccgaggt ccagagagag gtactaagac tacaaaggga 48300
gatgccaccc ccaaatcctt ctttctttat ctccaagtaa ttctagccaa ggaccacatg 48360
ggagggtggg tgggctcagc ccagctctcc ttctaagaac aaaaaggact tatgatgtcc 48420
cctgggctcc ccatttctct gtgagagttt ttaggctcaa cccatgaggc ctagaccttc 48480
ctgagaatgg acaggcaatt tatggtagct gaggaaagga ggaaacattt tctttagctg 48540
tgtgactgac cactgatgag tggcacatgt gcctataaac tcactgggta acatacacag 48600
aggggcatga aaaaaagagg ggggctagtt gagaagaagg gaggggatca ggagtgggag 48660
ggagagaaga aaggggagcg atgggtgaat atgatcaata tacattgtat acagggatgg 48720
aaatgtcatg ataaggccat tattatatat aattgataaa tgcttttaca aaatcagaac 48780
agaaagataa gctgaggagg aagttcagaa tcacaaataa gtaaaataac aacagggaaa 48840
aatctttctc agaacgttgc tatggagata gccacatgct gtgtgagtgg agacctcagg 48900
ttttcctatt gggcaagatg cattgagtag ctacagtcag ggaaagccag gaggtctgaa 48960
cctcgatgcc agagagccca tgcagagttg agaacaggag gaaggttctg aggagcccgg 49020
agggtggatg tgggtgacaa cttcagaaga agaagggcag gctggaagcc agtatatgga 49080
gacagatgtc attcctggac ctcacggcta ccttgctgag ctcactttct gccagcagga 49140
gaaacatgcc ctgaagatgt gaagatgcca gagaccggta cagaaaagcg agaggagcgt 49200
tgttgtggtt ggttgtatgt gctgacttga tcaggctcca gggtgctcag gtatttagaa 49260
aagcatttgt aatggctgtg tctgcaaggg tgtcttttga tgtgtgctac cgtgacctgg 49320
cagagtgaag tatacattgc tctccccagc cctggtggac ctcatccaac ccattggagg 49380
cctgtgttgt gcaaaatcgc agaggtagga aaatgtcttc cctctgccta tttttgagcg 49440
tgagcgtgaa tgctcttgcc tgtggagtaa gacatagact ggaccttacc tgtgttagac 49500
ctccatgctt cttggattag gatttggact agaatttatc agctgttctg ggtttgctgt 49560
tgtgacccac aggtcatcac actcctcagc ctctgtagca ctgtgagacc attagttata 49620
agaactcctg gagttggaga gatggctcag aagtgaagaa tgcttcctgc tctttcagag 49680
aactggaggt cagctcccag cagctgtatc accatcacgt gacttacaaa cacctgtacc 49740
tccggttcca agggatcaag tgccctttct tgcctctgtg ggcacccaga catgtgcata 49800
aacgtacaca gatatacaca taaataaagt aaaataaaat aacatgaatc ttaaaggaag 49860
aaacccagtc aatcatcacc catcctgcct gcatcctctt ggttctcttt ttctctgggt 49920
caaatggatt gccccataca agcatcttct tgctgccttc tctacaggct ggggctaaac 49980
agggaagtta tgggtgggga caactttcag acagatcaag aaggaggaag gagcgactca 50040
tgattttcaa agacaacaca aatgttggca gtttggggat gtaaccgatg agggcagtgg 50100
actcaggggc agacccgtgc gcatgcgccc acgtgttgcc atggcaccaa caccatgcgc 50160
tcaatgggat ctagccacac ttacgttaat gctctggtac tacagagttg gaacttttag 50220
taagtttgag cgaggagtaa tatatcagtg gtgatgagca tgcagggtta ggtcccttag 50280
agaaatggtg actagggtgg gaagtgacac agctgttgcc atatcaaggc tagagagttg 50340
ctccaccgaa tagccataag tcctagtatc agcctcagag ttcaggaact ctgcttttct 50400
tgtttgtttg tttgtttgtt tgttttcttc agacgattct gtgaagggaa gatggaaagt 50460
gttaattata taaactgaag acgtttccct gtgaagtaag gccagcccat acccagcctt 50520
aggctaagtt tcacttgccc tttcgcaaca caaacctttg tccctagatc tgactaagag 50580
gttaagcaat gtgaataccg gtggccaggc ccttcctctc cccagaagag agaagaggtc 50640
cccgaggcag cagatgtgag tcaagtgcct tgtggtagag gaggccactg gagtagacct 50700
gggaaaaggt tctgacactg tttatgactg ttgggctggg cttgatcaga ccaagcacca 50760
aacgcagagc tatgtatgcg cagctctgac cttcctccag ggaggatttc aggatgggtg 50820
ctcatgaggc tccactcctc tatgagtatc ggtaggcagg attaatggtt gccccagaaa 50880
agtaatgttt tcttcagtgg tgtagctact gataagttgc ccatgtcatt gtaaataacc 50940
cctcactcag gctcttgtga ttaattcact ggggcacatg acatcaatga catcacacat 51000
acacacacac acacacacac acacacagag agagagagag agagagagag agagagagaa 51060
taataaaaaa ataaaaattt aaaaatcatc tagtctttgt taataaggat aatatacttg 51120
gtggtatact taaaattggt ggcaaaaaat catgcccgta agtaagcact gtctgagggc 51180
ttgcgaaagt ttctaaacct gtagttacag gcatcctcaa caaaaggcat ggcaagtcat 51240
tgacattagt gtcacccagg cacacagcca actcaggtgg gaattgttgg ctctgtaagg 51300
acaggcaaag gaaaaggtca cactcaaatg gctcatctct gtcatcctta gtagaaaaaa 51360
ttgaaaatga tattagtcaa gaaaggacta aataagatga tatgcctaat attcagggag 51420
accaggataa tgtttcaaat gccctggaat aactggctct gtgtgtgtgt gtgtgtgtgt 51480
gtgtgcgtgc acgcgcgcac gcacatgtga gtgcacagat ttatgtctga atggtcttca 51540
gaaattaggt gatattccac aggaaggatt ttccatccta tcaagaacct aagaatattt 51600
caaggaacca gatcactatt tagggaagag ggaaggtcgt gtattatatt agccagatat 51660
acttcactca gatatgattt tggattacac atggtggtgc acacctttaa tcccagtact 51720
tgagaagcag aggcaggaca ggagacaccc agggccaacg agacccacat gaatgcacac 51780
cccctcatgt gtcagtgaga gctctcgcac actctccctc tcataatgag aaatgagaaa 51840
aggagaaaga taaaatatct gctattcctt gtattagtca aaaaacttcc tgcgtttgag 51900
gatagcttcg tgtgtactta gatatttaga aagtctcagg taaaccagtg cttaatagtt 51960
tgtctcaaac aaacaaacaa gcaaacatga tttgaaccaa tggcattggg taggaaggct 52020
ttgggcttca gataacaaag ctgaaggaag gtctgctcta gccacagctg aacgtccagt 52080
cctcttctct aacaggaagt ctgcaggaag ttgctctcca agtccacgca gcacttccag 52140
ggcgtaagca gctcagagtc tctgaacttg cctgcttgtt tcgctgcttc ctcttccact 52200
ccaggtggga accacggctt tgagcgacag agtctcatat gtcagcttct tgaggcagga 52260
gagagagagt gataatgcta gaggattgtc ttcccccttc cccccccccc ccgccccact 52320
ctgacaggaa gagccttcgc caccgtgaca acctgcctgc gatcatctta acttagtgga 52380
tagaccctca gacgagtcac tggctgacaa atatagacac ccatgattgg cttacagcat 52440
agtgttcatt gcttcctttc ttttccatct gcagtccagt ggggaccatt aaaactaagt 52500
caaagggaaa actattcatg gttttttaaa atttttttaa attttaaaga gagaaatatg 52560
aagggctagg gagatggctc gggggtcacg tgtgtgttgt acaagcatga agattagagt 52620
attatcttca gcaagaaggt aaaaaacctg gatgtggcaa gacctgtaat cttggcactg 52680
ggaggtagag accgaaggat cctgaggctt cctggtcaat cagcatagag cttcagatac 52740
tgtgagaaaa ccaaatggca gagagggata aaagaagatc cccggtgcta gcctcatgga 52800
catgcacaca agcatgcaag aatgcacacg cgcgcgcgcg cacacacaca cacacacaca 52860
cacacacaca cacacaatca taatgagagt agagaaaagt agaaagaaag acagtttatt 52920
attccttgta ttggtgaaac cctccactaa ggggcaaaag ctattgtaca ccatgaacac 52980
ctgcaggctc aacccttggg tgcagaggga gaagactgca caatgaattc cacaccaacc 53040
atggagaaac ataaattaac gaacaaatag gaaagcaagc aaaaaaaaaa aaactagact 53100
ggaaggaggg attctgggtc atggaaatat cattcgccat tgatgaattt tatttttatg 53160
ttcatttttc agctccatcc ctactcctta atgtcgctgc catgttcctg tgctatggta 53220
aatctcttga tttaaaccaa aagctttcct tacttccttt cagaatttca cttacgttac 53280
tctctctcct ctccctcact tacaatgaat aatcttggaa gaaaacatgt ctgcatagaa 53340
aaggactttc tggttagttc ataatgttgt tccacctata gggttgcaga tccatttagc 53400
tccttgggta ttttctctag ctcctccatt gggggccctg tgatccatcc aatagctgac 53460
tgtgagcatc cacttctgtg tttgctaggc cccggcatag tctcactaga gacagctata 53520
tctgggtcct atcagcacaa tcttgctagt gtatgcaatg gtgtcagcgt tcggaagccg 53580
attatgggat ggatccctgg atacatcact ggaaagagag gcccattgga cttgcaaact 53640
tgatatgccc caggacaggg gaacgccagg gccaaaaagt gggaatgggt gagtagggga 53700
gtgggggtga gggtatgggg gacttttggg atagcattgg aaatgtaatt gaagaaaata 53760
cgtaataaaa aaatattaaa aaaaaaaaaa gaaaaggact ttctacctta ctggcaactg 53820
taggctctta ggcgagggct ctcgcctcag tcatacgcgt cttcctctct gtaaagtgag 53880
ctggctaaat tagacacatc cgaaggtcac atagccccag ttctgaaact tgatggttct 53940
aaagtctgcg gggacaagca catgaccctt ctccaacctc tggtatcagg ttctgttccc 54000
actcgtttta ttcattatct gctctgtccc ctacttaacc cagacttatt tgtgcagtct 54060
ctgaatgagc aagccaggct tttttttttt ggatgatatt attagatgct cctgaatatt 54120
ctccaagtgc tttaaatgaa aactctggac agtacagcca gacttcccaa gttgccaact 54180
tgtcccaggc cttagaagtc acctaattac attgaattct gcctggtgga gatgaagaca 54240
gaaagcctgt cactaatggt gcatgtgttg agggtggtga ccactccatc tttattgcca 54300
gctatgctaa agcccttgct gcatcagaag gagtgtgagc ttgtaaagtt ccgagtctgc 54360
agcatgatct tccattctct aagcggtaag gcttaatgtg tgtgtgatgc tgaccagtga 54420
aggaagattc tagcaatatt ctgaaagtga tagataagaa atcaatacta aaatccatgg 54480
ctgagaatcc gtctttggtt aatgggtagc cacagaaggt gggagagaga tttctggata 54540
cttcaaggag cagaagaata agatcagcca gaggggctgc tctgagcatc gattgctgct 54600
gctgctgctg cccctgccgc cgccgccgcc gcctttgtcg tctttgtgta ttttgtggcg 54660
ctaaaagaat agcaagcacc aggcagcttc taatgaacaa atgcttgtga ttctggaggc 54720
caaatccaaa actgagatac tgacatctgg aggggccttc tggctgtgtc taatatcgta 54780
gacctcatgt ggcagaacca caaatggaga gagaaaacta aaagggtcca cactcactct 54840
tcactaggaa tccactcctg caatggtggt cgtaatcccc tcaccccatt ctttcagctg 54900
aatctttttt ttttttcatc aggttctgcc gcccaacgct attgcgtagg gagtacttct 54960
agcacatgct tatgggagtg tgttatcatc acaagagttg gtaactttca aggagacagt 55020
gtgagggaag gctgtagaaa tatttaagag gcaacagact tggtcagtca atgaagccag 55080
aactctaagg ggaagtgtga tgctcactaa aggaaacata aaggactcca cccctacccc 55140
ccacccccgg gtgaacagaa ctcttctgtg ctgtcccagc cttgcacaac agcaacactg 55200
ataccctact cccacagtga cagaaaagga cttgggactc ctatgaagga cgagggactt 55260
gactagagct cactaccttg acctttcact gttagaagtg gcataaggtg aagagctaca 55320
gcttaggggc tggagtgatg gccacttgct gttcttccag aggacccaag ttcagttccc 55380
agcacccaca tcaggcagct cgcaacaatt acccatgatt gctaccattg atgctgatgc 55440
cttcttccaa cttctgaggg tacctgcatt cttgttctct ctctctctct catctgtaaa 55500
aatcatatta agaaaatata tatttgggtt taaaatcaaa atggaagata caggttatag 55560
agatatattt agcaaaggaa ccaagaacac ttgatttctg tgccagagag tcacactttc 55620
ctcaaagagc tcccaaggag aaacaataaa aataaataca gctcttactt tgcactagat 55680
gctgttagga gcactttaac tccattagct gattttgttc ttataacaga tgccagggca 55740
agagaaagct gtatcagtca cttgagaatt gaagttgatt tcatggcagg cggtgggaca 55800
gagagaggaa agtgggctgg tccttacaaa gcacagatgc agaaaagtta cactgggaga 55860
caaaaatgag aagagatgca gagtagcctg gctagctggc tgggttcatt catttactca 55920
ttttaccttt attgagatgg ttagagggta agtctgtgct caccatagtg acaaactttt 55980
aaatgatgct tgtgcttcag ccccctccag tatcacctca gtcttatcat tcgaacactt 56040
ggtcctgacg ggctttgctt tttgaccttg tacatttttt taaaaagcga tttttatttc 56100
tttttatatt atgcctgtgt gatgtaattg tcccacatga gtgccacggc cacgggagcc 56160
tgaagagagt gtggcatctt ctggaactag agttacagat ttgtgagccc tgtgtgggtg 56220
ctagaaacca aatccaggtc ttctgcaaga gcagcaagca ctcgtagctg atgagctatc 56280
tctgtagctt ccggataatt attttgatga caaatgtcta cctgagcctc catttataac 56340
attgcaatca ttcctagaga tgtgcactag tagatttgta caatagagtg caaatcagca 56400
tatttcatga agacttaaaa gcttaaggtc cttcagccat ttggaatggg caaactgctg 56460
ggacatttat accatgcagt gttgtatagc agagaaaatg ggtgaatcat cattacatgt 56520
gagtgaaggg ctggagagat ggttcagtgg ttaagaacat gtactgctct tacaggagct 56580
tagtacccag taccatgtca ggcagctcac aactgcctgc agttctagct ccaggcggga 56640
atcgaatacc tctggcctct gagagcaggc atataccacc atacacatat atgcataatt 56700
taaaatgaaa ataagttttg aaaacaatta aaaaataaca ggatgaataa agactgaaca 56760
acatgtttga gtctatgccg gggcctagca aacacagaag tggatgctca cagtcagcta 56820
ttggatggat cacagggccc ccaatggagg agctagagaa agtacccaag gagctaaagg 56880
gagctgcaac cctataggtg gaacaacaat atgaactaac cagtaacccg gagctcttgt 56940
ctctagctgc atatgtatca aaagatggcc tagtcagcca tcagtggaaa gagaggccca 57000
ttggacttgc aaactttata tgccccagta caggggaatg ccaggaccaa aaagggggag 57060
tgggtgggta ggggagtggg ggggtgtgta tggggacttt tgggatagca ttggaaatgt 57120
aaatgaggaa aatacctaat aaaaatatta aaaaagaaaa aaaaaagact gaacaacaaa 57180
aacaaaccag aagttccagg agaatattgg ctccgcactt tatctttttt aaggtccaaa 57240
tgccaaaaca ggtatttagg tagttgttgt ctaagccatt tgttgccgat ttaagtaaaa 57300
gtccatccat tttctgtgcc tgctaaaatt gatactttta aagcaagaaa atgaaacagg 57360
aggaaattca aggtggagga tgtctcggtg gagcaggagg gcgtgaagag agagcacacg 57420
gaagtgaggc tgttgaccgt gttctcactg tgctgggcag ttgagacata gatacttatt 57480
tggaaaagaa ttaaactcga gggactcagt ggaatggaaa aagtcagcta tgggtggaac 57540
accagaccat ttcatgaact gggacttgta aatgttctca ttctggcacc tgctgagctc 57600
ctagtgacat aagagaccta agctccagat ttattccgaa ttaacaaatt gagccagatc 57660
ctcagatctc gtggaagaac aagcaggtgc tctcgactaa tgagccacct ctccagtccc 57720
aaggtataga gctttgatct ccatttttct ttatgtacaa atatttccct aggcattaaa 57780
ggtgtaattt ccataatcta ttcagtgtat caggctgtgg tcatactgaa taagaggttt 57840
tcttcacaga agcatcctgt acattaaata gaaagatcaa ttttaaatga cacctgagct 57900
tactccagtg tctctgctaa tttgttgaac ttttccttca taatctcttt aaattaatta 57960
ttaactagcc caaagcaggg tggacttggg cattatagag tacctggtca atttagaaat 58020
cgtttagtcc aagtcattag aggattatta cccttttttt tttcttcagc cagatggggg 58080
atgtcataaa tgtacacaat tagggttctt taaattaggc ttatggcttg gatgtgaaat 58140
gtcccctaga agctcacatg cttgattact tggtccccag ctggtagcac tctttcagga 58200
ggttggacag acacacagtc tcattcatag ttggtggggc atagggatga aacttgaggg 58260
ttacggatcg cctctgattc tgtcctggtt gctctgtttc cagatccagt cacatgtgag 58320
caagctatct cacactcccg ttgtcataac ggactggttc tgtttccatg tgtttctcat 58380
ggcggtgatc gactttatcc tctgaacctc gtgcaaaccc tccatgactc aagttggtcc 58440
tcctattagg tgtttgccct ctgtcatgag aagagtgaca cccatagtag gctcctttcc 58500
atccatctcg catgtgcccc acggtcaggt tctgttggtc taaggctgac catcaactgc 58560
tgctgaacat atatatatag ttgagaaact tttccagtca tactttccaa gaaataaata 58620
ggagcttgag tgtggtgagc tgtagctctc agctggccac tgatgtaatt attaatcact 58680
gcatgcaatt aattgggacc tttcttagac atgtttgcca ctgatccctg tttccaggga 58740
gtttcacaaa tgttcccacc ccagcctcgt acctctattt gttcttttgt aactttataa 58800
aaattttaat ctatacaagt ttgcaatgca ttgatcatat ctattcccac cctcaccttc 58860
ctggttatcc gagattctcc ccaccatatc cctttgaagt gtcagatctt cctcttctgc 58920
tctttataac ctactaagtg gtgttcatat gggcacaggt gtaggaacat tcaccacagc 58980
atgagcaacc tgtaagagac cacattcctg aagaaaactc ccctttctcc ccaggggaca 59040
tcaacggcca ataactctca gttatggatg gggtaccttc cgtttatcct ggaatgttga 59100
ctggatgaat ctgtgtaagc agccactgct gctgtgagtt cgttaagtgt aatggcctca 59160
tgttgaagtt aagccctgga tcttcctcca agctccgtgc tcccggaaat aaggctcaga 59220
ctcaaaatat atttacaaat accttggcca tgtaactagg ctcttctctg actagctata 59280
acttgaaata accattgatt ctagcctaca ttctcccatg tgattggcga tatgagctca 59340
ggtaccaggc atctgtcttg tcacatcttt tcagtgactc tctctgcctc cttctctccc 59400
agaattcttt ctcctcccac ggttcacctt ctatttcctg cctaagccat agcccatggg 59460
ctttttagct gacaggtgat gcattcatac agtagacgag atgttctgtt tatagccttg 59520
ccatacccag aagacactgt gtcacaacag tcactcccca tcctgacctg cagcccttat 59580
gaccttttgg ccctctcttt cacagtgttc cctggggggt ggtaatggtg gtggtatgca 59640
tatatgtcct gttttgagag caccgcatgg tcattccaca tttgttctta agtggaagaa 59700
agcatgatgc aaaacagaag gagtgagcta gactttaact ggatttaggg gactttataa 59760
gagaaagtaa aaacgtcctc aagaattcat taaaaatgaa gagcatctcc cccatgctca 59820
tttctgttca ttacaaacga ctcaactatt acatgcaaat attactctag gaaaatagcc 59880
acccactgat atgggtgtgg agatctccaa agacaagagg aagttgaaaa gggctcagat 59940
ggctcctcca atgtggcctt ccagcttatg acaagagaaa cacaattgct ggtccaggga 60000
cagatgtctg ctgcacttgc tttgttcctg gctctccctc tgacccaatt tacagccccc 60060
ctgcagctgt ctcctgcata ctttcccacg tgaagttatt tatctttctt aacagtcaac 60120
tcgatttatt ccaagagaat gctcccctcc cccagctctg ctggtaatct attcctgcac 60180
taaattgcca ttgtaatcaa aattcctaga atagtttaag ttggccttct gcagctgcag 60240
tcacctctgt caaagccctg gccaagcctc ctcagtgccc tggagtgagt gtcattccac 60300
attgctggaa accacacccc atctggctct tcccgccttt ccaggctcct tttgctgtgt 60360
ccttttatca tctctactga accactttcc tgacaaagct ccaacacggt tcctcctcta 60420
gagctaccga cctcttcaac tcctatgtgg tcattttttt ttctgtcctt ggccatttct 60480
taacccattt ttttaggaca tcctcttctc tccttgaaac ttggtcagat ctgccaccat 60540
atgtaccact tactcaatat tttgatcccg gagctcagtt ccgtggtggc taattttgtc 60600
aacagacaac atctggaatc atctaaaact caagttgctg ggcacttctg tgaggcagtt 60660
ttttaaaatc agattatttg aagcaggaag acacatccga catccgggcc ccactttctg 60720
atggcagccc agataacatg acgtggaaga aggacacttg gctttttttt tttttttttt 60780
ttgcctgctt gccccactgt gtctggcatc tctcctgttg ctcaggcatt ccttcactat 60840
tcagaatccc aacaaagata gaaaaccatc tgctctccag gaatcctcca ggatcccaga 60900
gctaggtgag gactgctgag acacccagcc ttgtggactg aacagctgcc agtttagata 60960
ttggtctttc catcatgaga ctgccattgt tgaactactc ggaccatatc ctgtaagcca 61020
gccttataaa tgcatacaca cacacacaca catgcacaca cacacatgca cacacacaca 61080
cacacacaca ctcacactca cacatgcacg cacgcacaca cacacatgca cacacactca 61140
caaatgcacg cacgcacaca cacgcacaca cacacacaca catacacaca ttcactctca 61200
gttctgttcc ttcagagaag cctgactaaa tcaggttccc agcacctatg atgggcagtt 61260
cacaatggcc tgctaatcta gctctgggag atctccttgc ttcttctcat ctctgcaggc 61320
actgtactca ttgtgcacac ataaatacta atactaataa taatagtaat gaaaattata 61380
aattcatatg cataccagtt tttattagtt ggcaacagat tgcataacca caacaccact 61440
tcacaaccag aaaattgaca gactatacta gtcatatcca ggtttcatag ttttgccctg 61500
tgcttagaca tgcatatttt cagctattca ttgattgctt gccatactag aaactgacct 61560
acacaggcta agccagtgct ctaccgctga gatgtatccc cagccttctg gttccatctg 61620
acttaagttg cccaaggtag cgttgatccc aatctgtaac acaggcatac ctgaaacttg 61680
caatccttct gcctctgtca cctgcgtagt tgagatttta ggccggtgcc actctgtctg 61740
taactttgtt atgtggagag actcgtgtgc ctctctatga gatacacttg ggaagaaaga 61800
acctgccggt taagggatgg cctccatcag gttgcctatg gggatgtgtg tggtaccttc 61860
tctgtccagt ttactacggg gagcatcttc cctaggcagg tcgcttaggt tgtctaagaa 61920
agctagctga acacggagca aaccactaaa gggcatccct ctgtggtttc tgctttaagg 61980
tcctgctttc aatctgtctc ctgtcagatg aaacaaaccc tttcctctcc aaattgcgtt 62040
tggtaatggt gtttatcata gaaaaagaaa accgagaaaa agaaaaccac catagtcaaa 62100
cttagactcg tcccatcagt ggcctcttgt gatacctttt agaaccaact gccacctgtc 62160
ccttctcccg acctgtgacc agcaataata tgtctccaga tttatacttt gattaatttt 62220
aagaatgttg cataaatttt atcaaacacc atacggaagt ctgaaatttc cctccccagc 62280
atgattctct tgatatccac ctgagttgtt gtgtagaccg acactgttct cattgctatt 62340
ggtgagtagt atttctgaat gtggacttgg tagtttgtct aattgctcgc ttgttgtgag 62400
atgcttgggt tatttctagt tattgaaaat caacatatat gaaaatgcat atgtagattt 62460
tgtgcacttt cacttctctt ggataaatgc cttaggaaaa tgttttctgg gtcatatggc 62520
aggcatatgt ttgatttcct agagacatca atgcagtttt tagactgatt gtcccatttt 62580
acattctcag tagctgcgta tgagtctgac atccttgcca gtgtttgttg atgtccttaa 62640
attttttgaa ccattctgat agtagggtag gatctctatt ttatttatat atgtgagtat 62700
gtgtttgtgt gtgagcatgc gcatttgtgc atgtatgtgt gtatgtgtgt gtgtgtgtgt 62760
gtgtgtgtgt gtgtgtgtgt gtgtgtgtgc atgtgtgtgt ggaagaccat cctcaccctt 62820
ggagctggag ttataggcaa ttgcgaacca catgagatgg gaagtgaact caagtcctct 62880
ggcagagtcc tctgtgcccc taaccactga gtgacccctc aactccttag tgtatcatac 62940
tgtatgttta ctgagtgttt ctatgatggc ttatgctgtt gatcctcttt tcatatacta 63000
ctttgtcatc tttatagcct ctttagtggc agatctgtct tttctaagtt tcctagtcta 63060
atattttaat cactgagttt tgacggttct ttatatgtct tagatagtgc caacctccac 63120
tctgtttaga tgagcagaag gtctatgggg ttaaaaggct ttttcagtca tttagcaacc 63180
gagaaaggaa agatccaagt ctgcccctgt ctttatgcag tctttaccat ggctcatctc 63240
atatgtagtg tcttcccaac tcatcaagct acattcatct tagcatacat agtctcccaa 63300
accaaaaacc cataaccagg gtatacatcc ttttggtggg gaattgtctg aagtttgtct 63360
tctaaagtgt ccagcctgtg ttagtcattg tatcgcccta tatagtcaac aggggtgggg 63420
atggaacaca acacctaagt atccctttag ccccgaagag ccttcagttg tcactcctca 63480
tcaaaactat ttaactagag tcatctcatt caaattcaag tccccttgcc agattaaaat 63540
atagctgatg agtagttatc atgaaggtaa agaagccagt cacacggcta gggagatggt 63600
caatgggtaa agtgcttgac ttgtaaaccc taggacccaa attcatgttc ccagcaacca 63660
cataaagtca aacgtggcat cttgtttctg caagccgagg tgtgaagggt gaagaagtga 63720
atcccaggga cttcgggtgg gtcaatctag ttgaagcgat gagttccaag tttagtgaga 63780
aacaacgtca aaaaataagg aagaaagaaa ttgaggaaga cattgtgata tcatcctctt 63840
tcgtgtacat gcacatgggt aggtaagcac gcaccactca cacacacaca cacacacaca 63900
cacacacaca cacacacatc aattcttcat agctctaagt ggattctttt tgtcaaagaa 63960
tcagctgaag cttaatggag attgcatacc tgagctcttg tcttctacag ggattgtaag 64020
agcaatgccc agatgactct tatgtacaca gctgtcccag agtctgtttt ctaatcactc 64080
agcctgtgaa aactggtgcc atccatgact tgaacaggct ggtggtcttg ggagccagat 64140
cactttccca gtgggcactg aggagctcca cctgccacca gatagcagag tactgattag 64200
gccttgaacc agaaatgacc agaaaagcat gttatagatg agaatagtac agtggatgtc 64260
atgttctagg tgtctgagaa atatggagga aaatgaccct aatcataaag aaattatagg 64320
gtagatatta agcacgccta aattattaac cagacaataa gaggacatga gagattaatt 64380
gaaggttaat agctcattgt gaaaggcagg ggcctctctg gtagcttata aagatgctct 64440
tggcttttgc aacctgaggc ctgagaaatt gtggcctatg acttaatagt aagaatggtg 64500
gaacaacaat gaagggttaa gacctgaagt gaggccatgt cataagttgt tgggccattg 64560
tcctcaccca ggttaggaaa caatggaatt tgacacatat ggcaggagtg gattatgtca 64620
aaaacaataa aactgaattg aattaactgt attggatcta gagttgtttt tttttttttt 64680
ttttttttaa attctgtgct gtaagcttcc agaaaaggca tactccttcc tgttaaacac 64740
cagtgctctt ctgatgtatc aggactgtat tagttacctc tctgtgactg tgagaaaaca 64800
ccatgacaaa ggcaatttgt agaaggacgg gttttactgg gttatagttc cagagagata 64860
agagttcatt atggcaaaaa gagaaggctg gagataggta tgggagctga gcaggaagcg 64920
caaaggccaa tggcaaacat gaagcagaga gaacaaattg gaagttgggt aaagctcaat 64980
gcttgttgtt agtgatgcac ttcctccagg aaagttatag ccccacactc ccatcgcctc 65040
tccaaacaat tctgccaaca ggggaccatg tgttcaaatg cctgtgggag atagttcaca 65100
ttcaaactac cacaaaaacc atacagtgct ccatgagtta ggaaaacatg cctgctttac 65160
cagattctct cctggtcacc aagctaaacc ctaaggatat atcaccacaa cctggcagag 65220
gactgagctt ggtctggtaa tggaagaagg tataaaccaa aaggaacatc aggtcctagc 65280
cattaccata agtgggactg gattgtgtaa gttttgcctc aaaggtggca ttattctaag 65340
ttagatgatg gaggatctgt ttcttgaggc agggtctcct tggatacagg agttaccatc 65400
tatcaagata ggataaagct gtggctggca tgaatagaat catgatagat gatttaaagc 65460
ctatgtgggg gatggaagca gcctccccta aagtaaaagt ggaaatgcat tattgtcatt 65520
gctatggatg ctttctgggc aataaaagac agtgggatat gacatacagc tagaagtctt 65580
atttaataat ttctattatg atgctataat gcaaagcatg gagatacgga cagatacgat 65640
gagtactggt ataattaaga aattcagcag taaatagctc ctgaagtcat ttctaatcag 65700
agatgtcatt gtggagattg tggagattgt ggattgtgac acagatagga agatcccaaa 65760
ttaacagccg caggggttcc atttcaaact tagatgccag gtgacagcat ttaccaaaac 65820
agaaggtcaa gtgcaaaaga acaatcagga gatctgactc caagataaca atggcaattg 65880
tcaacacagc ttcctagcgt tggggagaaa agagatgtca agagacaata aaaccattgc 65940
acgcaccaga gcaagaggag ccaagagtgt atgagcaaga tcctagagac aaggtttctc 66000
cacagtgtgt tctgtcaccc aggttcagag ctggcccagt tttcaaacac agaacccaac 66060
gatgaagtga tcaggtgtcc tggaaaaaaa aaaagatttc ttcaaaacca tggtgactta 66120
acaggtaaca attccctgac acttccctga agcaatcttc aatcaccaac tcagttagcc 66180
ataagttatg ggaatgtttg gttccaaaca tgtcaacctg acacaggatc atacacagat 66240
tcaaagtatc aacatgaacc ttctgttaca ctgggagcac acctggccat gaatggaagc 66300
tcagaacagt ttcaggatta caatgtgtcc acagagtagg taggctcaac cagtgatcct 66360
ctctcctgtc ccagaatgta acattgaaga agtgcacttg gcattgggcc cagcttgggt 66420
tcctttacct gtggatgaaa cttaatgagg gaaacattaa taacattatt aacattaata 66480
acataattaa aacataatga ggggttggac agaagcacca atgagaaccc tgttgctcaa 66540
atctgcccct tacaaaggta taaaatgtgt gttctttctt tgttctgggt ctctcctctg 66600
gcctgcgtgc tgagagggga gtccccaaca tgttggatca ataaaaatcc aataaggcca 66660
cactcctaat agtgccactc cctagcccaa gcatatagaa atcatcacat tccagtctct 66720
gaaccccaga ggcttgctca aacatatggg acataactaa acctaacata atgcaaagtt 66780
catttagtcc aacttccaaa gtcctcatag tctgtggcgg tctcaacaat gttttaactt 66840
aatcttttaa gaccaaagtt caaggtctct actgagattt actcaatcac ttaactgtaa 66900
tctccaaagc aagacaggaa accaaatggg taaactccaa actttggatc ttcatgtctg 66960
atgtcaaaac tctcttcaga tctccaacct cttttttatc tttgttgact gcaacaaact 67020
tctttctctt gggctggttc cactccctgt tagcagattt cctcagcaga tagttcatgg 67080
ctctggcatc tcaaacatct tggggtctcc aaggaaaatt caatgttaca gcttcttgtt 67140
tcaatgtctg ggatccacac ataatcttct gggattctcc aaagggctgg tgtcacttct 67200
ccagcactgc cctcggtggc attctaagtt cagagtgatc cactccactg ttgctgctgt 67260
tcttggtgat catcccatgg tactgtgttg tgtctgctct tgaccagcaa gaaagacaca 67320
acggccagat tcttctcaac agcctttatt gcaggaatgc ctcaatgctg ctacagggac 67380
ctagggaacc cagggaggtc tgcttatata ctctccagca cagggaaagg cttcatggcc 67440
ccctgggatt ggtcagtctg ccggcaccta atttgcatgc acccgctccg gaggggttgg 67500
cgccagactc ggacttacat ctgcgctgat gttgtttatg acaatggcac acctggtgcc 67560
cagagccatc ttagagttgg cttcctacag tactggtatc tccaatactc tggggccttc 67620
tactgcaacg aggcttcacc aataacctct cataggttct ctccatggtg ccaagcctca 67680
acttcttttc atgacccctt cagtcctggg ctgtcaagtg caactgaggc tgcatcttca 67740
ccaatggcct tccatggcct ctcagagtgc caagcctcag ctgctcttta tgttcccttc 67800
atcccttcaa aaccagtaac acctgagtga tggggatgga tgtagatgag gtgaaaccca 67860
gaacacctct cattccctgc aagggaagac ccatgcctgt agccagaaat gttaggatta 67920
gagcaaaacc cttagtagaa actgctgtga ttctcatttg gaagaccatg gactgatctg 67980
tcagcagtgt tattggaggt agcctttttc tttctccatt gtgaagttga tggtccttgg 68040
gcagacttca agaaagggtc tgaggagaca gacccaggaa gagtgtagca ataacatttg 68100
atttgcgatt aagaaggctg gagtcataat tagccctaaa tgggacaact ctatcaccct 68160
ctccaatgct cagggaagag gagacagaaa gaatgtaaaa gccattctgg gcttgacata 68220
gctgttgtct tcatgtggtg acctgcacta gagctgcagg cgactgggca ttcatcaagt 68280
gtgtgggagg gtcccctgag gccccacccc tcccttcagg actaacagaa gttagtgctt 68340
gccaagggag tagctatcat cctctgcagt gacacggaag ctgacaagtt acccatgctc 68400
caggaaataa actcccaccc acgctcaggc aggcgactta ccttagactg agtaagtcac 68460
acacaaaaga agacatgaaa gaaggagggg ctcttcgttg agactaaggg tttcaagtgg 68520
gagaaagaga aggataagac tattaaaatt cattacatac aggtatggaa ctgccaaaga 68580
agaaaatgat gaagagcagc agctgccgcc accgggagtg agtcagaggt ggcctgcaag 68640
cctgcaggaa cctggccctc accaacagaa aaggcggagg acagacacct gacaagagtg 68700
ttctcttccc tccactaagt gtcttttaca gtttacatgt tgatttggga gactgttaat 68760
tctgggatat gcggggggtg gggtgggggg aacaactcca acattctgga ccaaatttaa 68820
agcaaccttt attaaatatt agatattgac caagggatgg accttagttg ggaccatttc 68880
acagaacttc ccacctgaga atggcctgag ccatgggttg caggggcaaa gggcaaacct 68940
ataggccact gtactttccc atgatgcttt gctgtttcct aagaactata attcccagca 69000
ttgcaggaag ttactgggtt tctgggcagg taaggcttac aggttaattt tgggcattat 69060
aagacaaata ccaaaatatt atctatgata ctattgcttt attttatttt attttcaatt 69120
acatatgctt gtatgtgcat gagagtgcaa gtgcccacag aggttagaag gaggtattag 69180
gtatcctgga gatggagtta caggagatta tgagctatca tatagatgtt ggaattaaac 69240
ctcagtcctc tggaagagca gccaatgagc catatctcca gccctatcaa cctgttgggt 69300
tgtttaaaaa taattctttt atttttattt ttaagtatgt gtgtgtttgt gtgtgtgtgt 69360
gtacatgggt gcagtaccct aagagaccgg aagagaacat tggattcccc ccccccccac 69420
cgcccccacc tcccgagctg gagttacagg cagatgtgtc ccttggaaac caaactcagc 69480
tcgcctagaa gaggactgga ctatcgagcc taagcgccca tctaagtctt tgtatccagt 69540
ctttctgcaa ccctggaagc ctttttacca aaaagtacat tctttcatcc tagctgtttt 69600
ttgtgactag cacctgctga aaaaaaaaaa taagaaagaa agaaagaaag aaaaaaccca 69660
aaacatcatc aaaacaacaa aaagccaagc ccaccaacaa gaaacggata tacacaaaag 69720
ccaagaaaaa caaaacaagc ccccccaagc cccagctatt catcaagata ggaaagagaa 69780
acacccaact cctacctgcg cttggtgatt gcttggtgaa aaataaaagt atttttcctc 69840
tcattccttc ttttgtgatc aaatgaataa tgaagggatt gagcctttgc tagtgtgcat 69900
gcccctgcag ggagccaaga aacaaatagg tttcctaagg gtataaccca gccttttcgg 69960
cttttccgtc atcacgtgat tgagggcttc tgcttcccac ttaacctgca tccttcccag 70020
actgattcat ggaacctcaa gggctctaca ggaaaattca aacatcagct tctctctgcc 70080
ataggacttc catccgaagg aatggttcct tggttgttgc cttcacagcc ctcacatccg 70140
ggctggacct ggcagaaagt tgacatttga cccctatcta gagcatagac gatgctggca 70200
gccgtatgtc ctcacttttg ccattccggt gcctccctcg gggcacagcc aaggttccga 70260
gatgggcatt ttcaggagga aacgatttta tttgaggtct tggcagggag atgagaggag 70320
gaggcgtgcc accttctgta acaaaaggca tttcccagcc ttagacacac ccttaggccc 70380
agatgtacac tcccactcct gtcaatccaa ctgcactgac tagcaaccct aatgcctgct 70440
gcttccaggc accccgcagc ctgcgtcttg tttccactat ttcctctgcc tgtcgcaggg 70500
aaagcctcac taccaagagc cttcaaacac agttcctgtt actaattttg ccccaaaggg 70560
taccacagtg attaacttaa tgcttcccca gggatgactc tctctgtctg gggtcagggt 70620
ggggctggat ggattttctt tattaaggat ggtgggaacc ctcttttgag ctttgaagtc 70680
tcgccttaga ttttttttta attttatttt ttatttttga taactacaaa gggacaggaa 70740
gtctcttttt actcctctga ggcttgctgt tctccagggg catggaaaat gtacacgttg 70800
ttagcccccc aagcctgggg gctggggccc gcgctctgcc ggattgtttt tatatcccag 70860
caaaaagcat ctgtgtgcag aacagcagct ggtctgctgc tgccaactgc acgttcccag 70920
taccaatgta agcactttcc ttagaggtta aaacccccaa ggcactgttt gtgtttggag 70980
aagaaatgct ctaaaaatag taagtggggg tttaaagtct cttcgtcaga tgttcggaag 71040
cacgctgacc tggtgcgctg cttcttagaa ccagagctca ttggcaggtt gctgtgcctt 71100
gcacctacga ttcctgactc cttcagtaag ctagctggtg aagagctgga gaatctgtat 71160
ttataataaa tccccgggtg gggcattgat gttgctgatt ttaagaacac acactgttgt 71220
agccagtcaa aagaccctta ctcagaaaga ccacagagac cgccgccatc gctgcaaacc 71280
gcatgaggat ttttattgat ccaacatgtt ggggacaccc ctctcagcac gcaggccaga 71340
ggagagaccc agaacaaaga aagatcacat tttttatacc tttgtaaggg gcagatttga 71400
gtaacagggt tcttattggt gtagcaagta accctttcag gcattggttg gtttgtatag 71460
tgactaagta accctatggc ccagtgacta ctttgcttgc ccccatggtg ggttattatg 71520
atttggtcag caaagtaata gtactttaac atcacagcta ttaacgtcaa gggaattctc 71580
acaacaagct cagggtggtt tgtggtcttt gtcagaattc agtgtggggc aggggtcagg 71640
agaattgcta atcttgttat ggttacttct ctgagaacag ctagtattgt tttggtagtt 71700
gcaagcttaa tcattttgac caccaaaact atgtttttac atttgtttag tcagccggct 71760
tccctatctg gctctgcacg tggcctgcaa gtacagtttg gaaagtgttt ttcgaaggag 71820
gaaggtactg ggtggtcttg aattcatttt ggatattaca acacaaagaa ccactggtct 71880
ggtgtatttc cccccagtct gttgttggct gcagggtgta atacagacac agggtttatt 71940
accagggaga ggagggtacc atagcttgat gcaattcctt attacctgtg tcgccaagag 72000
caagtagctt aaccttgctg gtctctgttt cctcccttcc ttgacaatca tttctataga 72060
gctaatttat atcaggatct taattatctt gttttgtgga gggcacatgt ttataaaacg 72120
ttgatctttc tccctaccaa tattttttct cattgtcatt taaagagtca gttttgggac 72180
tgacaagatg gcttagtggg tagagaaggc ttgccaccaa ccctgatggt gggagctcaa 72240
tctttgggac tcacaaggaa gaaggagaaa acagactctg atctgtacac atttaaattg 72300
gcacgtgagc ccttctcctc aaataaagtc acacacacac acacacacac acacacacac 72360
acacagagag agagagagag agagagagag agagagagag agagagagag agagagagag 72420
aaagatacac acacacatcc catacacatt ttttggccag gttagacaat gctggggaaa 72480
gatatcagat ttatgcatct ctctctctct ggactgagtt ggtgactgtg ggaagggatg 72540
ggacttgact actgcaactt gtcagagcac agtaggccac tgtgaattgc agctctcaga 72600
ctcctggtac catcccatag tccagcacat gggagctaaa agtccaaata acaacaatgc 72660
tgtctgagga cttggaggca ggtgacattg tggtagggat ttgtggattt cgatgtgtgt 72720
ttgttctctg tttttaacac cttccatcag ataagttcct gtcctgtttc ttcagatccc 72780
aacctgtttt ccatttcctt ggggagcctt tgaaatatgt ggctggatct ggatgttatg 72840
aacttgtatg gagttctgca caagtcttta tagtttcatt tgattgcaat ccaattaatg 72900
taaggatcct ccctgaatga tgcgccctgt gaaagcaaac tccatgctta atctcttccc 72960
tatacttgtg tagtatgcat ttcttgactt ttcatgagac attcagagac tatcctataa 73020
aagtgtgtaa gtcataaaag tgtgagatta aaaaaaatag caggtgcaaa tgaatcacat 73080
tttcttgatc cattctttgg gaaacatctg ggttgtttcc agtttcttgc tattacaaat 73140
atagctgcta tgtacctggt agaacaagta tccctgtggt atggtggagc atcttttggg 73200
tacacgccca ggagcggtat agctgggtct tgaggtagaa ctattcccaa ttttttgaga 73260
aatcaccaag ctgatttcca gagtcgttgt actgttgtgg ccggccagca gctcgcaacg 73320
tgaacgtgac tgagatggcc actcgagcta agggaggaac tagtcgggga gaaagaagaa 73380
acggagccaa gacaagttca tcctgttcaa agctcaattt tactagttct gacattcagt 73440
tataaaggaa gggggaggga acccgattcc cgccaactgg tcttggagtc cagtagcagg 73500
gtgaacacgt gtgtggctcc aagcagcaaa gcagcacggt ccagcagtgg gcgtggcaga 73560
atgaatgagc gggaaactcc acccctgagc cagcaggttc caggctgggg gtggggaggc 73620
tgcagttgta caagtttgca cctgcaatgg aggaatgttc tcttcgctcc acatcctcac 73680
cagcatttgc taactcttga gtttttgatc ttagccattc tgatagatgt aaggtggaat 73740
ctcagagtca ttttatttgt attttccaga tgattaagga cattgaacat ttctttaaat 73800
gttcctctga cattaaagat tcttctgttg agaattctct gtttagctct gtactctatt 73860
ttttaagatt ggattatttg ttttcttggt gtttaagttc ttgagttctt tatttatcag 73920
tcctctgtca gatgtagggt tgttgaaggt cttttcccat catgtaggct gcctttttct 73980
cctattaatt atgtcccttg cattatagaa ggttttcagt gtcatgaggt ccaatttatt 74040
aactgttgat cttagcgcct gaaccatttg tgttctgttc agaaagttct cttctgtatc 74100
agtgcattca aggctatccc cactttctct tctattagtt ttagagtatc cagttttatg 74160
ctgaggtctt tgatccactt gcacttgagt tttgtgcagg atgataagta tggatctatt 74220
tgcaatcttc ctcatgcaga catccagtag gaccagcaca atttgttgaa gatgctttct 74280
tttttccatt gtatggattt ggcttctttg tcaaaaatca agtgtctata catgtgtgag 74340
tttatttctc tgtcttcgat tcaattacat tgctcagtta ttaaaagcaa ggacatcatg 74400
aagttttcag gcaaatggat ggaactagaa aatatcatcc tgaatgaggt aacccagctc 74460
caaaattata agtagatatt agccataagt atacatacag gatacccaag ctataaacca 74520
gaaacccaat tatgctaaat aacaaggagg gctcaaggga ggatgcttaa tctcactgag 74580
aaagtgtcct agtcagggtt tctattcttg cacaaaacat catgaccaag aaacaagttg 74640
gggatgaaag ggctttttca agctacacct ccacattgtt gttcatcacc aaaggaagtc 74700
aggactggaa ctcacacagg gcagaaacat ggaggcagga gctgatatag atgccatgaa 74760
ggggtgctgc ttactggatt gctcccctag cttgctcatc ttcccttctt atagaagtca 74820
ggaccaccag cccagggatg gcatcaccca caatgagccc tcctcgcttg atcactaatt 74880
gagaagatgc cttacagctg ggtctcatgg aggtatttct tcctcaaggg aggctccttt 74940
ctctgtgata acttcagctt gtgtcaagtt ggcacataaa accagccagt aaaggaggag 75000
aaacaaaata gtcattggag gggatggagg gaaggaactg gttgagagag gggctgggga 75060
gggaaatggg gagttggtca tcaggtgtag ggagagaagg ggaaaggggg ctgtgagagt 75120
gaatggaaat ttgtggcagg tgggagtggg gtgggggtgg ggaggctgcc atatcatttc 75180
taggatgtgt cagagacctg ggacagggga ggctccaggt agactatgag gggcctctag 75240
ctgagattcc ttgtaatggg ggatatggag tctgaaatgg tcacttcctg tggccagaca 75300
ggacctccca gtagagggaa aaggatacca acccacccac aaaacctttg accctaaatt 75360
tgtcctgcct acaagaagtt ccgggacaaa gatggaacag agacaaaggg aacgaccaac 75420
caatgaccag cccaacttga gacccgtgcc gtgggcagga actaatcctt aagatttaat 75480
gatactcttg ttatgcttgc agacaagagc ctggcatatc tgtcctctga gaggctccac 75540
ctagcagctg actgaaacag atgcagagac tcatagccaa acattagacg gaacttggaa 75600
aatgtggaag agttgaggga aagattgagg gacacagaga ggataggaac tccacacgaa 75660
caacagagtc aactaacctg gactcttgag agcttccaga gactgaacca ccaaccgagc 75720
atgggctgga ccttggcatc ctgcatttat gtagcagata tgcaccttgg tcttcatgag 75780
agtccctcaa caactagagc agggactgtc cttgaccctg ttaactgcct gcctgtggat 75840
cctattccaa ctgggctgtc ttgtctggcc tcagtggaag aggatgtgcc tagtcctgca 75900
atgatttgat gtgccagggt gggttggtac ccagcacccc cctcaaagga gaagaggatg 75960
agggaggagc tatgtgatgg gggtactggg aagagaggag agatgcaaat tggaagtaaa 76020
gtgaataaat aaataaatta attaatggaa aaaagtagtg ggtgctatga aggagtcatc 76080
tatattagat tttctggagt tataacaaaa tacttgagag aaatggagtt attttattat 76140
cgttttggag ataaaagtcc aaataacagt agtattatct gtggtaagaa ctactgtaga 76200
tggcactgtg ataagaattt gtcagttcct atgtctgtaa atgtgtagcg tgtgtgtgtg 76260
tgtgtgtgtg tgtgtgtgtg tgtctgcatg tgcatgtatg tggggtgtct atgtttgaga 76320
tggatatgga tgtgctgtgt gttatatgta tgtgtgatat atgtgctgtg tatgtggaag 76380
ttatgtgtgg gtatgggtgg gggctatgtg tgaaagaaag agagaaacag gatagggaaa 76440
ggaagtcaga gccagaccta tatggggaca gtaatgacct ccttatttag atttatctct 76500
taagggttaa agatgacatt attttttaac attgttgctc caggaccagg ctcctaatgc 76560
atgcagtctg agagacacat tcaaatcata tcctatacac agtaccatcc tttggccaga 76620
atattggtaa aaccatccaa atgttagagg agagtagcca acagttctgg catccgtata 76680
cagcactgcc ggcgtagagt gccctactgc cctgaagatg ccctgtgatt tcattgaaaa 76740
ttctttccag attggtaacc tctcagcccg gctctctgtg ccttatagat catgagatct 76800
gtaacataca acgtaacaat tagcttctca gttcttgttg gagaggctgg gtttataaga 76860
aagaaagcag ccaagcacat cagcccacgg gagcctggca taaagtgtac ctcagcagtt 76920
ccttagtgtt tgtagaataa agtaatgtat tatagctttc ctatagatcc acatggaagc 76980
ctgagaagct atgtggttct cctcagacct catagtctgc tcagattcac tcacttgggc 77040
gggttgtata gctctgggga agatttcact tctctgcctc agcaacacag gctcaggcgc 77100
atcctgcttt gggttgtgaa gttgaccgga agtgacacgt atagctttca gaaagaagtt 77160
tgaagagcca gcatgtgact gaccattcgt gcccttatac cttgtttttt ccaaggatta 77220
tgatagagcc acaggccatt gggtgctgat atttgttttc atggtgtaac taaatctgtc 77280
cgcagagcaa cacttctttt ttatgaagat aagaagtaac tgaggcaggt ttccaatcta 77340
gacatggtta ctgtagggtc tgctacttgc tagcttcacc cagctgaatc aagaagagaa 77400
aacaactggc caagcttgtt gggggcatac atgaaagtct agtacttagg aggtggaggc 77460
aggaagataa ggagtggaag gtcagtcttg ggtgcatttg tgtgtgtgtg tgtgtgtgtg 77520
tgtgtgagag agagagagag agagagagag agacagagac agagacagag acagagacac 77580
agagagagac agagagagac acagagagag agagacagag agacacagag agagagagac 77640
agagagagag acacacacac acacacacag agagagagag agagagagag agagagagag 77700
agagagagag agatattccc tggaatcagg ctcccattac aagcactaac aattccatct 77760
gatgccttgc aaattgtttc agaggcctgg gaaagatagg aaaattttct gcctattttt 77820
agaaagccaa tgtaacattg taccaaaatc ttataaagat agcattgaaa aaaaagaaaa 77880
ccaacatccg atctcattga aggagtaaca aatcctaaat tattaaaata ataacagttc 77940
agcaaagcat taaaatatac caagtgaagt ccccttttga caatcaacaa cggcacctta 78000
ccccacacac attatgactg actgtgtacc cctctaaaat aggacgaagg gggaaagaat 78060
gcattgcttc agaaaatgac ccagcaacat atgctagtta tctatttatt tttcttgcct 78120
tgacagaagc tagctagtat tatctggaag cagggaacaa tgtctgttga gaacctgcct 78180
ctgtccggat tgaactgtca caaggcaagt ctgtgaaggc attttcttgg tttaataatt 78240
gatgtggtag gtccagccct ctgtaggtgg taccacactg agtgtgtggt cctgggtcgc 78300
agggttaagg aacctgaaca tgagcctgga gaggaagcca ggaagcagca ctccttcatg 78360
gcctctgctc cacttcctgc tttgagtttc tagcttgaat tctcttcatg aaaaattatt 78420
ggctgggctg gcgagatggc tcagtgggtg agaacactga ctgctcttcc aaaggtcctg 78480
agttcaaatc ccagcaacca catggcggct cacaatcata tgtaatgaga ttggacacgc 78540
tcttctggtg tgtctgaaga cagcagcagc atacttattt atactaataa ataagtcttt 78600
gggccggagc gagcagaggt cctaaattca attctcaaca ccagatgaag gcttacaact 78660
aactatctgt acagctacag tgtgtaatca tatacataaa ataaataaat aaatctttta 78720
aaaattgaaa aattatttgg tgtaaggtaa agaaacaaaa acccaaacac cctttccttt 78780
tcaagtcgct tttagtcgtg gtgtttatca caggagctgg aggccatgta agatgcgtag 78840
gatgtagcat ttagaagcca tgtaggacac ctcgtttagt ggagctaagc cactagtgtg 78900
atataagagt ccgacgttaa tagacggctt taccaaggaa taatgaattc tgtatttcaa 78960
acggagtcgg gattggctta gggttaaaaa gaacctagaa gtcaaggttc cccaggctgg 79020
ggtggctctg atagacgagt gccaagcaca gctgcagata gcgcaaaagt atgacttaaa 79080
agatacatgc tataaggaag aaaagtgagg gaaaattgca aaatatgaaa atagcaagaa 79140
atttcatgta tgtatcaagt ttcccaaaca agggacaggc acacagtcac acagacacat 79200
agacacatag acacacaggc acacagacac acagacagga taggatatta agcactgcat 79260
tttgttcctc ttgttgaaac cctatgtagt ttcattatgt aatccaggct gtcctccgac 79320
tcatgctact ccggactcag tttcccaagt gctggggttt caggcacact gctaccttgt 79380
cccactgaaa gagttgtgcc tgagatggtc attacttagt gaaggacagt gagacttcag 79440
caatggagat ggcatccttg ttagtggatt tgtccactta aatgcattag acaaagtctg 79500
gcttatcatt tattattatt gttattatta ttattattat tattattatt attattatta 79560
ttttaagcat agagttagtg attactcatt cctatacttt cctattgtta aggaaaaaaa 79620
tctaaaatgg caaaatcaca atgtgaaata catatgcaaa gatcttaaaa ccaccagtcc 79680
gtgagtaaac cagttccttt tggagacaaa ggaataggca gtaaataaga gaaaaccaca 79740
tttgttaatg gatgggtagt tgttcactct agccatggag acactgaatc agcactcgac 79800
acgattcctt tacatactta cagaggacat tgattcgttt ctattgttac tgagtagctc 79860
caacttccca ggtcacaagt tgccaagagc agccaattat tcttaagttt caatttgttg 79920
aaaaaaaaaa aagccctgat agcattgatg ttcatccccg agcaactcag taactcagtg 79980
tgtgtgtgtg tgtgtggggg ggggtgtgtg tgtgtgggag ggtatgtctg tctgtgtgtc 80040
tgtgtgcata tgtggacata catatgccat gtcacatatg tggaaatcag aggacaacct 80100
gcaggagtta gttctgttct tgaaccatgt ggggttctgg gaattcgagt caagccatta 80160
ggtttggtgt caagagcttt ttcccgttga gccattttag cccatagaaa ctggttctac 80220
cacaaacatt tacaagatac aaaagctaag gacactgctt agtccattta aaatgatata 80280
ggtcccaaag cttcgcttac tgtgggattt tctcctatca tctcatccct ttctttcatc 80340
tggtctttag gatccttttc tgaaggtgtg aagttggtag agaagcctac tgtgtggaca 80400
ggaatgtctc tcaaatgcat caccattttg agtagtagtg attgagaaca aagggaattg 80460
ttgtaaggtg tggagttatt tgataaggtg tggttgtaac aaagcaccaa aactgggcca 80520
gggagatagc ttatcaggaa aagcacttgg tacagcctcc tgaatgccag agttggatcc 80580
ctggagtcca cagaaaaagc cgagtgtgga aagccagatg cagtgacagg aatttgtaac 80640
ttgggcattc ctgggaagag atgaaaggag aagatgggag aatggcctga agcttaaggg 80700
acagctatgg gatgtgtgct acaagaacag aaactaggga gactctgcct caaagtgggg 80760
tgggaaccaa ctacacacag gtatgttcaa gcagacacca cacacacaca cacacacaca 80820
cacacacaca cacacacaca cacacacaca cacacacatt attaaagctg ataacagctt 80880
ttagactaag tagaaggaaa aagagataac tgtagttaac aaaatctaat tcccaatttg 80940
ctacctacat tccctacctg cagtatgcta actttaagag ggaaaaagtc ctccaaccag 81000
agtgtatata aaatatgttg tctgatcctc ccaatagtgg ttttctaaaa ggaatatcat 81060
agaagatatt tagaagactt ccttttacgt tactttttga gacagggttt tatgtaagcc 81120
aagttgacct caaactttga atcccacttc tctacttcct gagagctaca gctataaata 81180
tgcaccatca tggctggttt acatggtgct ggggacagaa cccaggactt tgtgatgcta 81240
ggcaagttct ctaccaactg aggtcgatcc ccagccctca gataacattg tgtggcgcta 81300
ttctgtctac ccaagagagt ttatagttta gacttccaga tcaagcgaaa taaagagttc 81360
tggggagatg tccttttgct tcctagtgta ggtatagatg ttacgggatg gcaggattta 81420
gtcagaggaa gagactcaac ttctctgaag gtcttactat gcatacaact ttctgctatg 81480
gttcttatcc tgtggcataa ggacatcccc tgccacccaa ttttacatgc cacatcccaa 81540
atcattgtaa cgaggcttca catggcaacc agcagttgac tgcaatgaga cttccatggc 81600
aaccagcagt tgactgtaac aaggcttcca tggcaaccag tagttgactg caacaaggct 81660
tccatggcaa ccagcagttg acacctgcct tgctctggtt ttgttacagc tgaactgttt 81720
ctcatctgtg aaaccccttt ttaaaacatg tattcattta tcttatatgt gtacactgta 81780
gttatcttca gacacaccag aagaggacat cagatcccat tacagatggc tgtgagccac 81840
catgtggttg ctgggaattg aactcagaac ctctggaaga gcagccagtg ctcttaactg 81900
ttgagtcatc tctctggcac ccccgctccc atgaaaccct tttgcatata tctttttgtc 81960
ttctagtctt gtggtccaca agccctacaa gtcacttttg gagttcttcc ttagccccac 82020
tcccacattc ttgctttgga ttatcttcga cattcagtgc tctcagggca gctgtgaacc 82080
tccttgaaaa attttctctc ttgtctggtc tctaatgatg tgtagacttg acttactagg 82140
ggttcatgtc ttgctctctc tttcatgcag ttcaattcat atttagcatc ctaagtcagt 82200
gactataggg aaaggttttg agcccccttg gaagtctctg ctgcaagcat agatcttgca 82260
gagtagatat ttaatgaact cttattaaat ccatgcatga atgaaactct tcatgtgtat 82320
ttcccaatct tctctctaca tcattgaaag gggaataaca gaatttaaat tcttcacaat 82380
tcctgcaaag ggagacttct actaagtatg aaatgtgcaa ggcttgaatt tgtaatgaat 82440
gtctgatgta acccagcatt cccagaatca ccacttgggt tttccacaag ggtatgcatt 82500
cctcttttat acaaatgcat ggagggggag gggttacagg ataggcagaa atgaaagata 82560
tttgttaatt ttctgttatt gtgataaaac actatgatca aggaaactaa tcgaagaaaa 82620
aagtttatgt ggggttatgg tggccgagga ttagagtcca tagcttgcaa tggaggttgc 82680
aggtaaccag aacagaacag gctcacatcc ctgtcttcaa gcaggaaaca gaaagcatgc 82740
ggagtggtgt aaggcattaa acctcaaagg ccatcccaca ggtcacactt cctatacctc 82800
cccaaacagt gccaccaatt gggaaccaaa catcagagtc tgtggaggac atattcgttc 82860
aaaccaccac cacagacaag tagtttattc tgtgcaccct tcttatggag gaggctgaca 82920
agtaccactg tttacacaca gtaggactgc cacgaacaat atagccatac tcactacctg 82980
ctttcccggt ttgtggcctt cccatacctc acagaacttt cttcttcctg cctgtacatt 83040
tcactgctgt ctcttgctgt ggagtggggc tctatatgtg cgagggtctc agtgtgaagc 83100
aggctctgtg ctacttgtct tatcctgagt tacagagatt attttttgtc ccagtcccta 83160
tcaggagtca ctattttgag cccaatctgg tagctctggt ttcttctttc cagaatattc 83220
tgagtcgcgc agcctcaaac cggctctgcc tttcctctac atgcctgtga tgacgactgc 83280
ctggctgcag atgctccggg tgttttccca caccagtttc tcttgttgtg actccatcaa 83340
acccaggtca gcttctgtaa tcgagacgat ccacttaatt aactgtaatg aggctcccat 83400
catttccaat aaatttcttt ccaaaacacc acttgagagg cacatagctt cctatcagct 83460
gtaaattttt tttttcctgt ctatttagtt ccaggaattg aatttactca gagatgtcat 83520
tgcccaacct catgtctcaa tgttttaaac taaatctttc agtctggtgc tatgggctac 83580
aggacccaac cccagtttcc cttgtacaga atggaagatg ccgtgcaaac agcttgtctg 83640
ggtttcacca gagctgggag aatcagtgct ggttttcatg gcctcttctg cgatcagccc 83700
cttctccacc aacagttttg ttagttagac agagcaactt gcgcttgaag atctcaaacc 83760
atttatcgaa gcatgccatc ttctcctttt taaagacctg aaatgctgtt ggaataattt 83820
tgctgtgttt tataaaaata tagagaggat taatacgttt ggtagaggtg caataaggtg 83880
tggagggaag gggtgcctcc aaaggcctgt gctgaggcac ctcttccccc tgagcgacca 83940
gccaaagaat ggtatagtat agaatagagt ttattcatgg catggggagg ggagttgaga 84000
gagtagtaga gacagagaaa gagagaggga gagagagaaa gagagagaga ggggggggag 84060
ggagggagga agggagagag agagagagag agagagggag ggagagagag agagaagagt 84120
agtagaggct ggtcatgagc atgtggagag agagggggag gggaatgggg aatgggggag 84180
caggagggag aggacagagt cggagcaaga aagcaagaga gaacagaggg gctaagcagt 84240
cccccttttt tcattttaaa aattttatta gatattttct ttttttacat ttcaaatgct 84300
tcctataccc tcccctcgcc ctgctcccct acccacccat agcagcccct tttatagtga 84360
gtcaggcaca cctggctgtt gccaggtaac tggggcagag cctatacaaa aatgctaaca 84420
gatttgtcag tgaaatgata ttttgctctt tgacttatag aagatgaaaa agaaaaccac 84480
aagtttcata ctgacccttt ggggaggata catctttaag aaattatggg agagaatagt 84540
ttcatttaga aagaatttaa gtgttttttt ttcccctctc agacatgtca tggtttaata 84600
tcagttatcc aatttttctt tgtgctactc tcagaattct tcctgagaaa ttagctttaa 84660
tcttctgctt tgtttcaaag cctgcactag attaagcctc gtcctctctc tctctcctct 84720
ctctttctct ttggcttcat tcgggaatga ctaattagcc aggagaaatt aaatttacaa 84780
attaaacctc tctgcataga ttttctcaag accccagccc tgggggtaat atccatggcc 84840
tctcctacag agcttttgcc tcccagaggg ttgtatagag gggtgaaatg tttatgaagc 84900
cacatcggct tgaagagcag gttggtggtt ggcggttggc agcattataa gttgttcttt 84960
ggttccttca gggaaaaact tcagtgttcc aaagttcagg gtcatggaag gagggtgagg 85020
aatgttccca gccagagaag aaagtgatgt gtgtgagaga gaactgccga gaactgtaga 85080
actgaagttt ccaccgctcc aattacatgc ctgaatgcct tcttttcatt tcatctctgt 85140
ttattatctt tgtctgtgtg tggatggtgt atatatggta tgtgcattta tgtgtgtgag 85200
tgtacactta tgcatataaa ttcaagtgct catgttttac tccacgtata aagagatcag 85260
aggacagcct tgggtattgt tcattgcctt tcacctttct ctttctctct cttgaataca 85320
ccacctatca ttgtaggaga ctggcatcac agacctgcca tggctggctt tgtatgggat 85380
gcagggatgt gaatccaggt cctgatgtct atgtggcata gacacttaac taggacccca 85440
acccattcac ctcccaagcc tgactctgct cccctgctcc actctacaac atgccctcta 85500
ctcgataaag gcactaaaat gtgtgactag gggccatcca gtttgttctg agtgtcagct 85560
catgcctcct tcttaggaag catttcaagc caatgtctct taataccacc cacggttcat 85620
tgttttctgg cttctccttc cttccttcct tccttccttc cttccttcct tccttccttc 85680
cttccttcct tcctcccttc ctcccttcct cccttcctcc cttcctccct tcctcccttc 85740
ctccctttct cccttccttg ctttttcttt ctaacatctt ttgtgtattg aaaatgctga 85800
tgtttttgct atttggggat gagctcttgc aggatagtgt tccccaactc ttctcttcca 85860
agtttattct ccagatcttt gcattaagtt aggcaggctc ctttagggac agagaccgac 85920
ggcttactgg aggggaaggc ttcagtccca ttaaaagatg gttaatgaac attcaaagtt 85980
agtgtttctc tttgtttcag ctgcagatct tttggagaat cttaggagaa agcagccaag 86040
accactgaat ccacctgacc tcattaacct ggagcaaact gggcttatta gaatttagat 86100
tgaaggcctc agaggttaga tattgctctt ggagaagacc taggttcagt tcctagcacc 86160
cacataggtc ggattacaat tgctgataac tccagttcca ggggatctgt cactttcttc 86220
tgaccttcca ggtcttcatg cacattgtgc acatacagac aagcacacgc acacacacac 86280
acacacacac acacacacac acacacacac acaaatatta aaactctgga gtgtgaactt 86340
agtatgccca taggtaatta tgtccattag ctttcctcat tggacatttt ctctgtcacc 86400
tttaactcag gatgctcaca aatatcccta cccctctacg tacttccttt atgaatttgt 86460
atatgcccct tcccttgttt ggggagcaga tgtttctcta ctctttgatc tgactgttgt 86520
gctcactggt ttcatactca ccaagagacc tgattcgact taggtaccga gtcacccacg 86580
tctctcaggg tcagcctgct ctgtctctca gtttttggtc taagaaaaca aggccttcca 86640
cccttttgat cagcagatat gagtaaaaga aataaaagtt gatgctcttt gttttccagg 86700
gattcagata aaatgtttgc catatgcatg aaataatttt taagaggtag gttggttctt 86760
ccccctaaag caaggtttat ctaagaagag tgcttttaag gatggtcgtg atgctgacag 86820
tacctcgcat tcctaccgtc atttctggaa aagccatttt aatttttcat ctcacctcgc 86880
catctgggag acaagtgaac tcaatgtttt ccttgccatt tataaagtga gttagttaag 86940
actcgggtaa gactattgat ctgcaccaag atccaatacc aggaaaagag atgaaattgg 87000
tatccaaact tttgtttcag gactctgagc cctggcctct attgtctcaa acacagttca 87060
atcataaact gagtcaatac atctagcact gcctggcagt ataaggcaat taaactatca 87120
caaggctatg ggggtaaaga cactatcaca aaggtctggg ataaataaac ttgaacaggt 87180
tgataaagtg tgggactcaa tctctaaagg aggtgctgta atctctctgt agtggaaggt 87240
ttacctgaag gaacagattt gaagttattc ctgaaagcat actaaaacca gaagacagtt 87300
tggcagtccg aatcaaaaac tttaactaaa gacatgaacc acagtacttt ccagcatatc 87360
actcagtggc tctaaagttc ttttccttgt ttgaaaacaa tagagtccag gggaggatta 87420
aatggtgatt tgtaaagtgc caggctcagg gcacattcag taaatgttac cagtgattgc 87480
agaataatgg tgataatatt ttcctttgta ggaggaaata atgagcacgt agatttagca 87540
acacacagat cgtttgttgt gcttttaaaa gtcacagtga aaagttggaa acaacttgat 87600
gtccagcaag agggaattgc agaagagagt ttcctggtat ttctaggtgc tagatcatta 87660
gatagccatg taaaagaata aaaggaaata aatatgttat tgcctagcaa gatggccatg 87720
aatttgttgt tgttgttgtt attaagacag ggtttctctc tgtagccctg gctgacctag 87780
atctatagac caggctggcc tcaaactcaa agatcgatct gcatctgcct cctgagtgct 87840
ggggttaaag gcttccacca ctgctgcctg gctataaatg tttaaaatat attttctatt 87900
aattcttcac aaattccata tatgtgtaca gtgtattttg accatattca cccctactcc 87960
tcttcccaac ccctttcagc tcccctgctg ccatatttcc atcccttacc aattttgtgt 88020
actatttaat taatagatat atacatatat atatttaatt ctgatatatc agcacattat 88080
atattatatt atattatatg ttacatatat tatctgttac ataatataca tgtatacatg 88140
tatgtatata tatatatata tatatatata tatatatata tatatatata tacatattga 88200
tgtacaccca ttcattggag tctggatgcc ttgccaggga ccactcttaa gcaaagtggc 88260
ctctccctga tctggaagtc ccttgactgt taacagatcc ttagctaggg ctggagactt 88320
gggagcccca tgcctctcta agcaggaatc ctgacttggt cttgggctgc cactgtgagc 88380
tcatgaggca gtgttggggg agggatgctt tataccatcc cctttgtgac tgagaattcc 88440
acaaatgctc attctctgca cttggcagtg attttttacc tttcaaaaac acttataaaa 88500
tattaaatcc ttttttttta agtttgtgct tttttgatgt tgtttaacac atatattcat 88560
gtacagatac aggatagctt taaaaactag gagatgaatt tgcagctcta tgtcaacaaa 88620
actgacattt aaaaattgtt tttattaaaa ttctttttat ttaaactatc ccagtaacaa 88680
aggcaagtat catgtaaaat aaaattgtgc tgttttgttt tgtttctggc tttcttgttt 88740
cctactcttt cctttggttt gtcagctctg tgctaccata agcagacacg atccattcaa 88800
tagttgacta acagcattct tttgagtgtt tactgtggcc aaggccctgg ttctaagcac 88860
ttgatgtaca gataaaccag atgaacaaca atgcccttca aaagcttaaa ttcaaggctg 88920
gagaaatggc tcagtggtta agagcactgt ctgctcttcc agaggaccca ggtttgactc 88980
ccagctccca catggcagct tataaccatc tacagctcca gtcctgggag gtctgacact 89040
ctggtaccca cgtggtacat ataaatatat gcaagcgaga catgtgcaca tataattgaa 89100
atataggtat agtgatcttg ggattccagt gtctgaagca ggagaaggat gagactgaga 89160
tcagcctgga ataagatcct cttttgatta aaacaaaagc atgtactagg tgacatgaac 89220
agcacaaccg caagagaagg agagtagacc aaaatttcta gaggagctat gccttcttaa 89280
cagcattcaa cccctcttct gagaatccct gcagactgcc ctccagcatc actgatttcc 89340
atagaggctg catagctgtc aaagttcaca gtctactcag aggtaacctg ctgtgtcaat 89400
atttgtaatt tgtacttcat ggtgagtcac ttccagagaa tagattatct accatggaag 89460
ggaaaaggtc tgggagtgaa agtgagctgg acaagacaca ggtggaggca ttaggtttca 89520
acagcttcct gcctctacaa agcaaagggc aggaatgtgt gctggcgtgg gctggagccc 89580
agaacagcca caactctcaa gtggaggata agcagaaagc agggttagtc tcctgtttct 89640
ccaggtggtt ctagctgatt cttctaggtc tggaaacaaa tgttaccttc tatccatttt 89700
ctctccttct cccctggctt ccatttttat agctcagaag caaatccatc ttttaagagt 89760
tgttctcaag caatctttgt ctaaagctgg atcctcacca tactacatcc cacttcaccc 89820
ccacctccac cctcactgcc aattgaggaa gttctctgaa ttctgacacc tccatagcat 89880
gtgatagtcc cctatgttat tcctatgcat caattcattt ttacattgtg ctggagaact 89940
ccatctctct tacaagagta gatgatcatt aaggtttggt ctatagaact ccaaatagac 90000
tggactagaa aagaaattcc ttctgacaca taataatcag aacaacaaat gcactaaata 90060
aagacagaat attgaaagca gtaagggaaa aaggtcaagt aacatataaa ggcaggccta 90120
ttagaattac accagacttc tcaccagaga ctatgaaagc cagaagatcc tggacagatg 90180
ttatgcagac cctaagagaa cccaggccag gctactatac ccagccaaac tctcaattac 90240
catagatgga gaaaccaaag tattccatga taaagccaaa ttcacacaat atctttccac 90300
aaatcgagcc cttcaaagga taataaaggg aaaacaccaa cacaaggaca gaaactacac 90360
cctagaaaaa gcaagaaaat aatctttcaa caaacctaaa agaagactgc agcaagaaca 90420
gaatccaaac tttaacaaca aaattaacag gaagcaacaa ttacttttct ttgatttctc 90480
ttaacaccag tggactcaat tgcccaatga aaagacatag actaatagac tggctacaca 90540
aacaggaccc aacattttgc tgcttacagg aaacccacct cagggaaaaa gacagacact 90600
acctcagagt gaaaggctgg aaaacaattt tccaagcaaa tggtctgaag aaacaagctg 90660
gagtagccat tctaatatcg aataaaatcg acttccaacc caaagttatc aaaaaagaca 90720
aggaggggca cttcatactc atcaaatata aaatctacta aggtaaattc tcaattctta 90780
atatctatgc tccaaatata agggcagcca cattcattaa agaaacttta gtaaagctca 90840
aagcacacat tgcacctcac acaataatag tgggagactt caacacctca ctctcaccaa 90900
tggacagatc ctggaaacag aaactaaaca gagacacatg gacactaaca gaagttataa 90960
aacaaatgga tctaatagat atctacagaa catcttatcc taaaaaaaag gatatacctt 91020
cttctcagca cctcatggta ccttctccaa aattgaccat ataattggtc acaaaacagg 91080
cctccataga tacaaaaata ttgaaattat ctcatgcatc ctacctgatc accacggact 91140
aaggctgatc ttcaataaca gcataaataa tagaaagcca acattcacgt ggaaactgaa 91200
caagactcta ctcaatgatt ccttggtcat agatgaaata aagaaagaaa ttaaaaactt 91260
tttagagttt aatgaaaatg aagccacaac atacccaaac ttacgggaca caatgaaggc 91320
agtcctaaga ggaaaactca tagccccaag tgcctccaaa aagaaactag agagagcata 91380
cactagcagc ctgcagcaca cctagaagct ctagaactaa aggaagcaaa ttcacccaag 91440
aggagtagat ggcaggaaat aatcaaactc agggctgaaa tcaaccaagt ggaaacaaaa 91500
agaactattc aaagaatcaa ccaaaccaga agctggttct ttaagaaaat caacaagata 91560
gataaaccct tagccagtct aactagaggg cacttgtatc cagtctaact agagggacag 91620
tatcctactt aacaaaatca aaaatgaaaa aggagacaac aacagatcct gaggaaatcc 91680
aaaacatcat cagatcctac cacaaaagtc tatactcaac aaaactagaa aacctggatg 91740
aaatggacat cttcctaggc agataccagg taccaaagtt aaatcaggat tagattaacg 91800
atctaaacag tcccatttct cctaaagaaa tagaagcagt cattaatagg ctcccaacca 91860
aaaaaaaaaa aaaaaaaaac caggaccaga tgggtttagt gcagagttct atcagacctt 91920
caaagaagat ctaattccaa ctctcctcaa actattccac aaaatagaaa cagaaggtac 91980
tctaccaaat tcattctatg aagccacaat tactcttata cctaaaccac acaaagatcc 92040
aacaaagaaa gagagcttca gaccaacttc ccttatgaat atccatgcaa aaatactcaa 92100
taaaatcctt gcaaaccgaa tctaagaaca tatcacaatg atcatccatc atgatcaagt 92160
aggcttcatc ccagggatgc agggatggct taatatacgg aaatccatca acataatcca 92220
ctatataagc aaactcaaag acaaaaacca catgatcatc ttgttagatg ctgagaaagc 92280
atttggcaaa atccaacacc ccttcatgat aaaagtctta gaaagatcag gaatttgagg 92340
cccataccta aacataataa aagcaatata cagcaaacca gtagccaacc tcaaactaaa 92400
tggggagaaa ctcaaagcaa tcccactaaa atcagggact agacaaggct gcccactttc 92460
tccgtactta ttcaatatag tacttgaagt cctagccaga gcaattagac aacaaaagga 92520
gatcaagggg atacaatttg gaaaggaaga agtcaaaata atcactattt gcagatgata 92580
tgatagtgta tatataagtg atcttataaa ttccaccaga gaactcctaa acctgataaa 92640
caccttcagt gcagtagctg gatataaaat taactcaaac aaatcaatgg cctttctcta 92700
cacaaaggat aaaagggctg agaaagaaat tagggcaaca acacccatca caataggcac 92760
aaataatata aaataccttg gtgtgactct aactaaggaa gtgaaatatc tgtatgataa 92820
gaacttcaag tctctgaaga aataaattga agaagatctg agaggatgga aagatcttcc 92880
atgcaggatt aattggcagg attaatatag tcaaaatggc tattctgcca aaagcaatct 92940
atagattcaa tgcaatcccc ataaaaattc caacataatt cttcacttag ttagaaaggg 93000
caatttgcaa attcatctgg aataataaaa aacataggat agtaaaatct attctcaaca 93060
ataaaacaac ctctggtgga atcaccatac ctgaccttaa gctgtactac agagcaattg 93120
tgatgaaaac tgcctggtac tggtacaatg acagataggt agatcaatgg aatagaattg 93180
aaggcccagc aatgaatcca cacagctgtg gtcactggat ctttgacaaa ggagctaaaa 93240
ccatccagtg gaaaaaaggc agcattttca acaaatggtg ctggcacaat tggcggttac 93300
catgtagaag aatgggaatt gatccattct tttttttttt ttttttccat tttttattag 93360
gtatttaact catttacatt tccaatgcta taccaaaagt cccccatatc cacccacccc 93420
cactcccctg cccacccact cccccttttt ggccctggta ttcccctgta ctggggcata 93480
taaagtttgc aagtccaatg ggcctctctt tccagtgatg gccgactagg ccatcttttg 93540
atatatatgc agctagagtc aagagctccg gggtactggt tagctcataa tgttgttcca 93600
cctatagggt tgcagatccc tttagctcct tggctacttt ctctagctcc tccattggga 93660
gccctatgat ccatccatta gctgactgtg agcatccact tctgtgtttg ctgggccccg 93720
gcatagtctc acaagagaca gctacatctg cgtcctttca ataaaatctt gctagtgtat 93780
gcaatggtgt cggcgtttgg atgctgatta tggggtggat ccctggctat ggcagtctct 93840
acatggtcca tcctttcatc tcagctccaa actccgtctc tgtaactcct tccatgggtg 93900
ttttgttccc aaatctaagg aggggcatag tgtccacact tcagtcttca ttctccttga 93960
gtttcatgtg tttagcaaat tatatcttat atcttgggta tcctaggttt ggggctaata 94020
tccacttatc agtgaataca tattgtgtga gtttctttgt gaatgtgtta cctcactcag 94080
gatgatgccc tctaggtcca tccatttggc taggaatttc ataaattcat tctttttaat 94140
agctgagtag tactccattg tgtagatgta ccacattttc tgtatccatt cctctgttga 94200
ggggcatcta ggttctttcc agcttctggc tattataaat aaggctgcta tgaacatagt 94260
ggagcatgtg tccttcttac ctgttggggc atcttctgga tatatgccca ggagaggtat 94320
tgctggatcc tccggtagta ctatgtccag ttttctgagg aaccgccaga ctgatttcca 94380
gagtggttgt acaagcctgc actcccacca acaatggagg agtgttcctc tttctccaca 94440
tcctcgccag catctgctgt cacctgaatt tttgatctta gccattctga ctggtgtgag 94500
gtggaatctc agggttgttt tgatttgcat ttccctgatg attaaggatg ttgaacattt 94560
tttcaagtgc ttctctgcca ttcggtattc ctcaggtgag aattctttgt tcagttctga 94620
gccccatttt ttaatggggt tatttgattt tctgaagtcc accttcttga gttctttata 94680
tatgttggat attagtcccc tatctgattt aggataggta aagatccttt cccaatctgt 94740
tggtggtctt tttgtcttat tgacggtgtc ttttgccttg cagaaacttt ggagtttcat 94800
taggtcccat ttgtcgattt tcgatcttac agcacaagcc attgctgttc tgttcaggaa 94860
tttttcccct gtgcccatat cttcaaggct tttccccact ttctcctcta taagtttcag 94920
tgtctctggt tttatgtgaa gttccttgat ccacttagat ttgaccttag tacaaggaga 94980
taagtatgga tcgattcgca ttcttctaca cgataacaac cagttgtgcc agcaccaatt 95040
gttgaaaatg ctgtctttct tccactggat ggttttagct cccttgtcga agatcaagtg 95100
accataggtg tgtgggttca tttctggatc ttcaattcta ttccattggt ctacttgtct 95160
gtctctatac cagtaccatg cagtttttat cacagttgct ctgtagtaaa gctttaggtc 95220
tggcatggtg attccgccag aagttctttt atccttgaga agactttttg ctatcctagg 95280
ttttttgtta ttccagacaa atttgcaaat tgctccttcc aattcgttga agaattgagt 95340
tggaattttg atggggattg cattgaatct gtagattgct tttggcaaga tagccatttt 95400
tacaatgttg atcctgccaa tccatgagca tgggagatct ttccatcttc tgagatcttc 95460
tttaatttct ttcttcagag atttgaagtt tttatcatac agatctttca cctccttagt 95520
tagagtcacg ccaagatatt ttatattatt tgtgactatt gagaagggtg ttgtttccct 95580
aatttctttc tcagcctgtt tattctttgt atagagaaag gccattgact tgtttgagtt 95640
tattttatat ccagctactt caccgaagct gtttatcagg tttaggagtt ctctggtaga 95700
atttttaggg tcacttatat atactatcat atcatctgca aaaagtgata ttttgacttc 95760
ctcttttcca atttgtatcc ccttgatctc cttttgttgt cgaattgctc tggctaatac 95820
ttcaagtact atgttgaaaa ggtagggaga gagtgggcag ccttgtctag tccctgattt 95880
tagtgggatt gcttccagct tctctccatt tactttgatg ttggctactg gtttgctgta 95940
gattgctttt atcatgttta ggtatgggcc ttgaattcct gatctttcca aaacttttat 96000
catgaatggg tgttggatct tgtcaaatgc tttttctgca tctaacgaga tgatcatgtg 96060
gtttttgtct ttgagtttgt ttatataatg gattacattg atggattttc gtatattaaa 96120
ccatccctgc atccctggaa taaaacctac ttggtcagga tggatgattg ctttaatgtg 96180
ttcttggatt cggttagcga gaattttatt gaggattttt gcatcgatat tcataagaga 96240
aattggtctg aagttctcta tctttgttgg atctttctgt ggtttaggta tcagagtaat 96300
agtggcttca taaaatgagt tgggtagagt accttctact tctattttgt gaaatagttt 96360
gtgcagaatt ggaattagat cttctttgaa ggtctgatag aactctgcac taaacccatc 96420
tggtcctggg ctttttttgg ttgggagact attaataact gcttctattt ctttaggtga 96480
tatgggactg tttagatggt caacttgatc ctgattcaac tttggtacct ggtatctgtc 96540
cagaaatttg tccatttcgt ccaggttttc cagttttgtt gagtatagcc ttttgtagaa 96600
ggatctgatg gtgttttgga tttcttcagg atctgttgtt atgtctccct tttcatttct 96660
gattttgtta attaggattt tgtccctgtg ccctttagtg agtctagcta agggtttatc 96720
tatcttgttg attttctcaa agaaccaact cctcgtttgg ttaattcttt gaatacttct 96780
tcttgtttcc acttggttga tttcacccct gagtttgatt atttcctgcc gtctactcct 96840
cttgggtaaa tttgcttcct ttttttctag ggcttttaga tgtgttgtca aggtgctagt 96900
atgtgctgtc tctcgtttct tcttggaggc actcagcgct atgagtttcc ctcttagaaa 96960
tgctttcatt gtgtcccata ggtttgggta cgttgtggct tcattttcat taaactctaa 97020
aaagtcttta atttctttct ttattccttc cttgaccaag gtatcattga gaagagtgtt 97080
attcagtttc cacgtgaatg ttggctttcc attatttatg ttgttattga agatcagtct 97140
taggccatgg tggtctgata ggatacatgg gacaatttca atatttttgt atctattgag 97200
gcctgttttg tgaccaatta tatggtcaat tttggagaag gtcccgtgag gtgctgagaa 97260
gaaggtatat ccttttgttt taggataaaa tgttctgtag atatctgtca ggtccatttg 97320
tttcataact tctgttagtt tcactgtgtc cctgtttagt ttctgtttcc acgatctgtc 97380
ctttgaagaa agtggtgtgt tgaagtctcc cactattatt gtgtgaggtg caatgtatgc 97440
tttgagcttt actaaagtgt ctctaatgaa tgtggctgcc cttgcatttg gtgcgtagat 97500
attcagaatt gagagttcct cttggaggat tttacctttg atgagtatga agtgtccctc 97560
cttgtctttt ttgataactt tgggttggaa gtcgatttta tccgatatta aaatggctac 97620
tccagcttgt ttcttcagtc gatttgcttg gaaaattgtt ttccagcctt tcactctgag 97680
gtagtgtctg tctttttccc tgagatgggt ttcctgtaag cagcagaatg ttgggtcctg 97740
tttgtgtagc cagtctgtta gtctatgtct ttttattggg gaattgagtc cattgatatt 97800
aagagatatt aaggaaaagt aattgttgct cccttttatt tttgttgtta gagttggcat 97860
tctgttcttg tggctgtctt ctttttggtt tgttgaatga ttactttctt ggttgttcta 97920
gggcgtgatt tccgtccttg tattgcttct tttctgttat tatcctttga agggctggat 97980
tcgtggaaag atattgtgtg aatttggttt tgtcgtggaa tactttggtt tctccatcta 98040
tggtaattga gagtttggcc gggtatagta gcctgggctg gcatttgtgt tctcttagtg 98100
tctgtataac atctgtccag gctcttctgg ctttcatagt ctctggtgaa aagtctggtg 98160
taattctgat aggccttcct ttatatgtta cttgaccttt ctcccttact gcttttaata 98220
ttctatcttt atttagtgca tttgttgttc tgattattat gtgtcgggag gaatttcttt 98280
tctggtccag tctatttgga gttctgtatg cttcttgtat gatcatgggc atctcttttt 98340
ttatgtttgg gaagttttct tctattattt tgttgaagat attagctggc cctttaagtt 98400
gaaaatcttc attctcatca attcctatta tccgtaggtt tggtcttctc attgtgtcct 98460
ggattacctg gatgttttga gttaggatcc ttttgcattt tgtattttct ttgactgttg 98520
tgtcgatgtt ctctatggaa tcttctgcac ctgagattct ctcttccatt tcttgtattc 98580
tgttgctgat gctcgcatct atggttccag atctctttcc tagggtttct atctccagcg 98640
ttgcctcgct ttgggttttc tttattgtgt ctacttcccc ttttagttct agtatggttt 98700
tgttcatttc catcacctgt ttggctgtgt tttcctgctt ttctttaaga gcctgtaact 98760
ctttagcagt gctctcctgt aaatctttaa gtgacttatg aaagtccttc ttgatgtcct 98820
ctatcatcat catgagaaat gtttttaaat ctgggtctag attttcggtt gtgttggggt 98880
gcccaggact aggtggggtg ggagtgctgc gttctgatga tggtgagtgg tcttgatttc 98940
tgttagtagg attcttacgt ttgcctttcg ccatctggta atctctgaag ctagctgttt 99000
tagttgtcac tgttaagagc ttgttcttca ggtgactctg ttagcctcta tgagcagacc 99060
tggagggtag cactctcctt agtttcagtg ggcagagtat tctctgcagg caagctctct 99120
tcttgcaagg caggtaccca gatatctggt gttcgaacca gactcctggc agaagttgtg 99180
ttccactcac tagaggtctt aggatcacgt gtggaatcct gtgtgggccc ttgcgggtgt 99240
caggcgactc agctggcaag gtagccgggg ctcgagtgga gtggaagggg tttgtgcccc 99300
agatcaagcc cgggtagcct gcttccctat gtaccgcagt ctcaagttcc acgcgattgg 99360
attggggtag gcgctgtgtt ccactcacca gaggtcttag ggtcccgtgg ggagtcccgt 99420
gtggaccctt gcgggtgttg ggcaagactc tgctggcaag gtagcccggg gctcgagtct 99480
cgagtcgagc agaagggact tgtgccccag atcaggcccg ggtagcctgc ttccctatgt 99540
accgcagtct caagttccgc gcgattggat tggggcaggc actgtgatcc actcaccaga 99600
ggtcttaggg tcccgtgggg agtcccgtgt ggacccttgc gggtgttggg caagactctg 99660
ctggcaaggt agcccggggc tcgagtctcg agtcgagcgg aagggacttg tgccccagat 99720
caggcccggg tagcctgctt ccctatgtac cgcagtctca agttccgcgc gattggattg 99780
gggcaggcac tgtggtccac tcaccagagg tcttagggtc ccgtggggag tcccgtgtgg 99840
acccttgcgg gtgttgggca agactctgct ggcaaggtag cccggggctc gagtctcgag 99900
tcgagcggcg aattgatcca ttcttatctc cttgtacaaa gctcaaaagt aagtggatta 99960
aagacctcca tataaaagca gagacactga aatttataga ggagaaagtg gggaaaagcc 100020
tcgaagatat gggcacaggg gaaaaattcc taaacagaac agcaatggct tgtgctgtaa 100080
gatcaagaat tggaaaatgg aacctcacaa aattgcatag cttctgtaag gcaaaagaca 100140
ccgtcaataa gacaaaaagg ccaccaactg attgggaaag gatttttacc aatcctaaat 100200
ctgatatggg actaatatcc aatatataca aagagctcaa gaagttagac tcccgaaatt 100260
caaataatcc cattaaaaac ggggtacaga gctaaacaaa gaattctcaa gtgaggaata 100320
ccaaagggct gagaagcacc tgaaaaaatg ttcaacatcc ttaatcatca gggaaatgca 100380
aatcaaaaca accttgagat tccacctcac accagtcaga atggctaaga tcaaaaattc 100440
aggtgacagt agatgctggc gaggacgtgg agaaagagga ataatcctcc attgctggta 100500
ggattgcaag cttgtacaac cactctggaa gtcagtcttg tggtttctca gaaaattgga 100560
catagtactg ctggaagatc cagcaatacc tctcctgggt atatacccag aagatgttcc 100620
aactggtaat aaggacacat gctccactat tttcatagca gtgttattta taatagccag 100680
aagctggaaa gaacccagat gtccctcaac agaggaatgg ataaagaaaa tgtggtacat 100740
ttattcaatg gagtactact cagctattta aaacaatgaa tttatgaaat tcttgggcaa 100800
atggatggat ctggaggata tcatccttag tgaggtaacc caatcacaaa agatttcacc 100860
agatatgcac tcagataagt ggatattaac ctagaaactt agaataccca agatacaact 100920
tccaaaacac aagaaaatca agaagaagga agaccaatat gtggatactt agaataagga 100980
acaaaatagc catgaaagga gttatagaga tgaagtttag agttaagaca aaagggtgga 101040
ctatccagag actaccccat cttgggatcc atcagccact aaacccagat actattgcat 101100
atgccagcaa gattttgctg aagggaccct gatatagctg tctcatatga ggctctgcca 101160
gtgcctggca aatacagaag tggatactca cagtcatcta ttggatggaa cacagggcct 101220
ccaatggagg agctagagaa agtacccaag gagctgaagg gatctgcaac cctatagatg 101280
gaacaagaat atgaactaac cagtaccccc agaggtcata tctctagctg catatgtagc 101340
agaagatggc ctagtcggcc atcagtggga agagaggccc ctaggtcttg caaactttat 101400
atgccccagt acaggggaac gccagagtca agaagtggga gtgggtgggt aggggatcag 101460
ggtcgggaga gggtataggg aactttcggg atagcatttg aaatgtaaat aaagaaaaca 101520
tctaataaaa tagcaataaa gaataaccac tacaaagaga gaaaaggaca acaaaagcct 101580
gcagtaagtt tgctagctga acagagcaga tgaataaccg gcagcagact ttgcaccaca 101640
tcatttcctt tggccatccg cacagattgc cggaacaggc aaaccagatc tccatgcatt 101700
ctgttgtccc caccctctgg gccataggac ttggacaaag gtaatgtcct ggatctgaaa 101760
gaagttaaga cactgggatg gtatttaatt aaataataac agaggctcaa ctcggtgatt 101820
ggcctggctg gaccagcctg atgtgttgat aattgtctaa tcctctagtg gatatcaaaa 101880
aaaatcattg ctttcccaag ggaaggggac agccaggaga aggagaggta tacatggatg 101940
ataaacgttc cagatactgg ctaagtgctt accagtaaat tgaagtccac atttcacagc 102000
atactccagg aagtcatttc tccccagcca gactcaacag tctttgaagg cttctaaagt 102060
ccagctggga ggtagtgttg agcctctagc atgtctattc atagactact agatcccatg 102120
agagctgcca ttacaattgc tggagtacat tttttcactt cctatcacct aaataaactt 102180
cacccactgt gtgggtttgc taatcccttc ctcatccttg ctgtatccac caccctgtct 102240
tgtttcctta gcaactagac actgctgagg gcagggcaga aggctaaaag ggagcaccag 102300
taagtggaat gagtgagtgg tggcttggtg ggctgcagag gggttagttc tcacgttgcc 102360
tttttgagta ttccccatca ttttctcttc tagtgcgcaa gtgcagggtc ctcacatcta 102420
tccacactgt ccacacagag agaacacatt tttaaaagct agcccaaaga gagaacaaag 102480
agctgaggat aactattcct aacccaggat gtctgcctta cattactttt taggtacttt 102540
gcatttgttt gctgctacta tcattgtttg tttactatat tttaggagtt cgaacaatcc 102600
caggcaccat tcagacagaa agtggcaaat gtcatctaaa agggcagggc ttaacattcc 102660
cgtggcagtg tgtgcttccc cagtcagaga gagcactttc ttgcttttac tgttttctaa 102720
ctcgagattt cccccgcttt tctggagctt tttttttttt gttgtttagc ttctcatcaa 102780
gaaagtataa gttgtaggct gcgggagtgt ctgtggggat gcgtttgttt tgtttttgag 102840
acagagtttg gctatttaga gaaggctagc tttgaactcc cagagaccca cctgcttgtc 102900
tcaagtgctg gcactgaaag tatgtgtcca catacctggc ctcgtgtact aattttttga 102960
taattacaaa aaagggcaag aaaaaaagaa agaaagaaaa tttctttctt cagccattca 103020
ttctgtagcc tgttgtgtcc aacactgatc taggcattct tttggggtac ttgagcagaa 103080
agactagact gtgtactttc tagctgggct cttcaccagc aggtgcacat ttcagtattt 103140
atttggccac ttgaaaatct cactgttgat tttgtgataa aaaaaaaaaa caaaacccag 103200
gaacttattt gtaaaacgat tattcctggt gtttatctga ctcaccttat catctgtgtt 103260
taaagattgg tggggtacac tctgagctat ttgtacttgg caagatcccc aactctgaga 103320
gcaaggtttt agctggctag ttttcctcct tcagcctctg ccaagtgctt ggtcctctag 103380
agaataatat gtaccttttg tccccacata ttaaatacaa ataaagagaa gaacatgtca 103440
tcttgaggca ttggaagcta ttaaggctat ctcaggcaat ctggacaact ctacgccttg 103500
gtcacatagt ggcttcttaa tatgtaccat ggctcactca agaaaaatgg agtggtgacc 103560
aacttcagcc tctgagtttt gagatggaga ctctgagata gctgtcaata ttttgtaaaa 103620
ctgcttccta acatcccgta cccctttctg tatgtatatc tgcatgcaca tgcacacata 103680
tgggtataga gcccgcactg gccaaaagat gagagcagat ctccctggat ccagaattat 103740
atatggttgt gagcttccct atattgctgc tgagagccaa tccagttctc tggaagagca 103800
atactcactc tcaactgctc agtcgcctct acaaaccaac tgttttttgt ttgtttgttt 103860
gtttgtttgt ttgtctgttt ggtttggttt ggtttctctt agacagggtc tctgactggg 103920
accgaggctt gctgagtagg gtaggctatt tgaccagcag ccctcaggaa tgcaagtatt 103980
ttcctcaaca tctgatttcc tctttccttt ctccctccct ccctccctcc ctccctccct 104040
ccctccctcc ctcccttcct taatttcttc ctttcttctt tctttcttcc tccttccccc 104100
tctcttcccc tctctctctt tctttttttc cattgccgac atgaagaagt agagatgagc 104160
atgaccaagg tcagtttctg cttttcctgt gacaagggtt ctccccagtc aaccctggtc 104220
tgcccacaga attcttatcc cactgaaagg aatagacatt tccctacatg aagagttgta 104280
aagtggtggt tggtcccatt gcatgcacag agagtgagag acgggtaacc tgtgagacac 104340
ctcctacata aaaagagttc cagtgatctt caaagtgttt gtcactcacc cagaaaaact 104400
ccagctcctc actaccaagc ctaggaaagg aagacagaaa tacctagaga ggaattccaa 104460
tcacctcaag aaaaatggag tagtgaccag cttcagcctc tgagttttga gatggagact 104520
ctgagagagc tgtcaatatt ttgtaaaacc gtttcccact cgatagcatt cccagagtga 104580
aggtttttct ctcctcagcc atgagctagg cttctggatt tctacatcct gtttcatttg 104640
tgttcttcct cctatattta agtgtaagct tgaatgagcg tctcagttca cttcccacaa 104700
tacgagaatt tcccaaacaa ggagggcaca ccaaactcat gttagcagtg cctcttcagg 104760
tgttgcccat ttttctcctt caaaagtccc caagcctccc aggtactact ttgccagttc 104820
aggttgttca ggggaggtac accaagtgct gattcccact gagctcctac tgaccctatt 104880
cagtattgtg ccacagttta cccttctctt ctcttctctt ctcttctctt ctcttctctt 104940
ctcttctctt ctcttctctt ctcttctctt ctcttctctt ctcttctctc ctctcctctc 105000
ctctcctctc ctctcctctc ctctcctctc ctctcctctc ctctcctctc ctctcctctc 105060
ctctcctctc ctttcccctc ccctcccctc cccctcccct cccctcccct ccccctcccc 105120
tcccctcccc tcccctcccc tcccctcccc tcccctcccc tcccctcccc tccttttctt 105180
ttcttttctt ttcttttctt ttcttttctt ttcttttctt ttcttttctt ttcttttctt 105240
ttcttttctt tgtgataggc ttgggaagct tcccctgcag gactgtggag ctcttgtgtt 105300
cacatttgtg ccttttggaa agatgcttca gcggctggac ccgaggcaag agtttgtctt 105360
caaaatgctg ccattgcctc tgtcagtttt catctgcctg taaacttttt ttttttcttt 105420
ttgccaaatc tcctgaagca acttgacctc aaggtttttt ttttttaatt ccctcaactc 105480
tttctttatt ctttgttcca ttttcactat cttttttttc ttattagtta agagaaacca 105540
aagaattgat tcacctgctc attagttttc tcgaatattc ccctgtgact aaagtaaaac 105600
taggctacac ccctaagaga aagatgcctc ttagggctcc tgtcatcttc ctattgtctt 105660
gactggtgtg catacaaagt ttgaactatg aaactagggc atggctgatt ttggctccag 105720
tgtttacttg tgaaccagtc tattcactat tgacctagct ttcagattcc acagcccttc 105780
tagcttccct aacataaaaa cataagcatt atatgtattt aggaagtatc atgttgtgtt 105840
ccaataatat ttatgcagtt tgacctcagt tgtgccctta atccttgtag tacctgtttt 105900
agttagggtt ttactgctgt gaacaggcac catgaccaag tcaactcata aaaacaacat 105960
ttagtttgag ctggcttata aattcagagg ttcccaccaa tgtcatcaag gtgggaacac 106020
gatagtgttc aggccgatat ggtgcaagag gagctgagag ttgtacatta tcataggaag 106080
gctgctagca gaatagtgac ttccgggcag ctaggatgaa gatcttaaag cccacaccca 106140
caagagcaca cctactccaa caggaccaca ccttctaata gtgccactcc ctgggccaag 106200
catattcaaa gcatcacagt atcttaatta gaaaagtggg agctatccct tgttcatctg 106260
tcttagttgt cttgactgct ataacaaaac acctcaaact cattcattca caaag 106315
<210> 5
<211> 171477
<212> DNA
<213> 人工()
<220>
<223> 合成
<400> 5
ggtgttcctt ggcaactcac tttttctttt taaaaattgt gtgtgtgtgc tgtgtgtgta 60
tgtgtgagtg ggtaagtagg tgtacagcag ccaggggagg atctcagatg tcttccccta 120
tcattctgcc ttgtgccttg tgcctttgag gcagaacatc ttggtgaacc cagagcttat 180
atatgtagac acacacacag atatataaac acattatatg tatataaata tatataatgt 240
gataccataa tatagatata tacacaagac acacacacat atatatgtaa tataatatat 300
gtaatttata tacacatatg tatatgaata tatatatata atatgctacc ataatataga 360
catatactag acacacatat atgtaatata tacaaatatg tatataaata tataatttat 420
gctatcataa tatatatacc ctagacatat atgtataata taacacatat atgtgatata 480
tgtgtgtgtg tgtatataca tatatatata tatatcacgc acacacacat acatacgtct 540
agggtagcaa ccaatcctag taatcctcct gttttcattc ccctcaatgg tctacaggca 600
tgtatgagac cacatatggc ttttatgggt gtatgtgtga tctaaactca gaccttcacg 660
tttgcataat aatcactgtt aactgctgag ccatctctcc ttctctcact ttcctttctt 720
tttgaaaaaa aattttttat acattatgtt tttattttat tttacttatt tttatttttt 780
taatattaga tttttttctt tatttacatt tcaaatgtta tcccctttcc tggtttcccc 840
tccaaaaacc cctatcccat ccccactccc cctgttcacc aacccaccca ctcgcttccc 900
tgtcctggca tgcccctaca ctggggcata tacattaggt tttgagcgaa ttccaggata 960
gccagggcta cacagagaaa ccttgtcttg aattaaaaaa aatttttttt ttaaattaga 1020
gttgctgcca tgagtatgag caacttaaga aaattatctc tcgccgggca gtggtggcac 1080
acgcctttaa tcccaacact tgggaggcag aggcaggtgg atttctgagt tcaaggtcag 1140
cctggtctac agagtgagtt ccaggacagc cagagctaca cagagaaacc ctataaaaaa 1200
ataacacaca cacaaaaaaa atcaaaaaca aaaacaaaca agagagagag agagagagag 1260
agagattctt tccctccaac ttctcccaga ccttccctac ctccattccc accaacttca 1320
tgtttttttt tctctctctc tctttctcaa aaccaaaaaa tgccaggaaa gcaacaaaaa 1380
ataagtagca agaaagtcag aacaaagaaa ttaaatacgt aagtaagtaa ataaaaatag 1440
aaaatcagca atattaaaaa aaaatcaagg actggagaga tggctcagca gttaagagca 1500
ctgattgctc ttccagaggt cctgagttca aatctcagca accacatagt ggctcacaaa 1560
catctgtaat gggatccgat gccctcttct ggtgtgtctg aagagagcta cagtgtactt 1620
acgtttaata aataaatctt taaaacaaga caacacaaaa atccaaaata aaatttcaaa 1680
gtgtaccaac acaaaacatg tagtctgttt tgtgttggtc aactactcct gggtatttag 1740
gcttccttgg agtgtggttg ctatacccag tgacactcag ttaagaaaag tgaatttccc 1800
tttcctggca gggatcaatt gcaagtagct ttttggttag gggtagaata ttatattcca 1860
ccttcctgtg ctggttccac ctgtaaatgt ctgtgcagag ctgtttatgt ttacgtctca 1920
ggcagagctc tgaggaagat attagtaagc aagacattcc ttggagagtg cttgggggat 1980
ccagcaactg tgaaaggaaa aagaaatatt aatcaaaggg ataaattaac cttcaataca 2040
gtttcagcaa aggcctctca tggtgctgtc cccagttgag gcaaggcaac agaccttttt 2100
cctcaccaaa cactcactgg tgtaggggca tggtatgacc tgtcatcagg cagggaacat 2160
tcaccacaca gagtggagag gagctgtggc catctcttca atcagagcag ggtgttggat 2220
ggacgttgcc agcctgtacc acccaccatt cacatcagct gctctgtgca cacagcacac 2280
tccaacccac agagaaggtt tgtttctgtt tttatttttg ctttttatta ttatctcatg 2340
taaaattatt atttatttta tttttgcttt ttttattatt atctcatgta acccaggttg 2400
gctttaaatt tgttatgtag tcaaggagga ctttgaactt cttccctcac ctctagagtg 2460
ctggggtcac aggcacgtat cactattcct gttcacctgg tacttggaat caaacccagg 2520
cttcatgaat aatagaccta aactcttcca aaccaagaag aaccacatct cacgagattt 2580
gacatgctgt gggttttttt ttttcctctc ccccctctgt ctctctcctc ttctgtccct 2640
ctttctccct cttctttatt tctttcattt ttatttttac ttttgaaaag aagctggctt 2700
caaaattctc catatggctg aggacgactt cagcctttaa tttctttttt tgtttgtttg 2760
tttgtttttc taggcagggt ctcactacac agccctggct gtccttgaac tcactatgca 2820
gactaggctg gcctcgaacc tggagatctg cttgcctctg cctcctcagt gctgaaattg 2880
aagacttgca ccaccaaggt atttttagtt aatcgtttga aaaatttata catgtttaca 2940
atgtattttg atcaaatcca acagaaatct tcctctcact tcttctcagt ccccctacat 3000
ctttcctacc ataatttctc tctttctctt ctttttattt ttgaaataac ccaccaagtc 3060
cagatagtac tgtctacaag tgcataaatg tagagccatc ggctaaagca tggccaggct 3120
actagtaatc ccactgaaca ttacacacgt tctttggtca aattaagcaa gcttaatttt 3180
ctgttagaca gggatagctc cctaaatcag actttgataa tatagcatga cacttaagag 3240
aaagtggggc ttgtagagcc tccaaaacct gcaagcctgg gggtttttta aggcttggga 3300
gacttccaga ggaattttga ttgcatagga acttggctag cagaacatct tatcttatca 3360
gggtgcattc aaggtgtgag tcaggctcca gagggtgggg agcaagtcgg attccagaaa 3420
cacacagtga gtgtttggtg aggaaaaagc acagtcaacc tgaattttgc agcagacaga 3480
aatgaacttc tgaccttata acaaaatggc ttccgtcctt aagatggcgt caggctggtc 3540
catcagtaac tacacccctg aagaaaagtt atttcctctc cctaactgtc accaattgcc 3600
agcaacttct cagctaggaa tagagcctca tgatttcctc tcccactcat actgggtgtt 3660
gactggcttg agtgccatgc cacgtcctga agacagcatt tcacagcatt tgtccctatc 3720
ctctggctcc tacggttctt ttgttccctc tgctgagatg taggtacccc gagccttgta 3780
gtagaagtga caggcatgtc ccatttatgg atgactactc aatggtcaca tactctcaga 3840
actgtggcca gttatgagtc tgtgttgact gctgcctact gcaaaaggag tcttctctgg 3900
gcaaaacagt agtaatctac atgtataaaa cacaaatgct tacaaggtag tttgatgggg 3960
gggggggact gtcaaacaac ccttgcacag gggtcaccta ataccatctg cacaggggat 4020
atttgtgcct tccctcagcc ttgagtaggc taaacaaacc catgatagtt ttacaaccta 4080
gctggagtct tctgacctca ccacatttgc aatttcctat agagctttga ggagtagact 4140
gcccactgag cttgctttgc aacataatct ggctgaaacg aaggatgggg tttgtgggct 4200
ttctcagtgc tgaaaattaa ctttgagcct tgatcagaaa cgtttgtctt tgcttcatcc 4260
ttctcttgca cccagttttt ttctcagttc caggcccccc cccgccccgc ccctttcagg 4320
tatacccagt ttgtccatgg ccactggaca gctacagata tttacattac gattcacaac 4380
agtagcaaaa ttagttatgg agtagcattg aaatagtttt atggttgggc atcaccataa 4440
cacgaggaac tgtcttaaag ggtcacagct ttaggaaggc tgagaaccac tgtcctgcag 4500
cctagctctc atgggtcctt gataaggttt gtagcaccag acatgaactt tttcctgtgg 4560
agcagccctc aaagacagtc agaaagagca gttggttatc ccaacaacca acatgtcact 4620
attatatcaa gggggctttc ctatagcgtg aatggtcctc agagggtaag tccatctttt 4680
ctccccacgt cgcagggata gcatttcctg gcaccatgaa agcaggccag tagaaaggaa 4740
gtttctaagg accttgtact tctgatcctc ctcctcgcat gtgttgggat tacaggcctg 4800
caccaccaca tccagtttat taggggctag gcatgtgcac agtaagccaa cactcaataa 4860
gcagaacgac actcagacct cagccccttc atttagtgtt agtgtgttgg tggttgttta 4920
ttattattat tattattatt aattcaccac acagcaattt atgtcctaca tgtcacattc 4980
atttttaaat tccctttact ttttccccta ctttgtttta gaatatatgt atatgtgtat 5040
gtgtatacac gcacacacac acatacatat atatgtgtat acacacatac atatatgtgt 5100
attcatgcat atacatatgt gaatatacac acatacacac gtatatatga gtatacacac 5160
atatacatat ataatatgtg cgcacacata tattttatat attagcattc cagcttaggg 5220
gcttcagtgt agctcattgg cacagctctt gtctagcgtt ccagttttat ttctactttt 5280
ggcttttaag tctatttgtt ctattgattt aaagcttaca gtacctcggt gggggcacac 5340
acctttaatc ctagcactct ggaggcaaag gcaggtggat ctccgagttt gaggccatcc 5400
tggtctacag atcgagttcc aggataaacc gaaagtagag aaaccatgtc tcagaaacca 5460
aaagctaaaa caaacagaaa agattcacaa caaatatttt taaatcatta caatatatta 5520
caatatcatt aatattacac ccctttaagg gtagtataag aatctttatg ttatgtgtct 5580
ataaaatggg ttgaggagct ggtgagatgg ttcagtggat gaaggagctt gttagcaagc 5640
ctgccaactt gagttcaatc cctaggaccc acgtgataaa aggagggagt agattctttg 5700
aagttgtcct ctgacctcca catgtatact atgtcacatg tgttcggcat aaaataaaca 5760
aaaacataga agggagccta ggagacagtg ccgttggtac aaagcctgct gcaagagcat 5820
gaagccctga gtttgagccc tagcactcgg tcttatgcat acagcacatg tctgtaatct 5880
cagcactggg gagacaaaag agtgagtggc cctggagttt gctgggctgc cagtcaagcc 5940
aaatcgacta gctccagata gggagtgggg cagagaaaga ctgagcccat ctcaatggtg 6000
ggcaatgatt gataaagaca tccagtcttg ccttctggct tcccataagt gcatccctca 6060
gtgatatact gttacctgga agagtaagcc aaccaagccc tttcctccct aactgatttt 6120
ggttggaaag gaggccattt ccatgaagct aggaattgac cttggatgga agatgctggc 6180
ggaagtttct ggtttagtcc aggtggcccc cgaagtgtgg gctacaccat ttcccagaaa 6240
cctctagtag gcatgcactc cagctaccca tgctggacac tcgttctttg atctctctcg 6300
tttactttct tattttcctt atattatttg ctcgtttatc cccagacatt cctgggactg 6360
tcttttacac aaattcttca catcccatga tgtctttccg gctctccgtc ttggaagaaa 6420
acacccaagt gactgactgt gaccaaacgg ttacatgcaa atgtatgaaa tctggggacg 6480
aatgcagtaa taaaaggtga cttaaagggg ctggagtgat ggttcagtgg ataagagcac 6540
tgactgcact tccagaggtc ctgagttcaa ttcccagcaa ccacatggtt cacaaccatc 6600
tataatggga cccgatgccc tcttgtggtg tttctgagga tagcaacagt gtactcatat 6660
aaataaatca atcttaaaag aaaataaaaa acatttcatt aaactcgata ataggtataa 6720
atgcgaactt aatggatgtt ctcagggaag ttgactgtaa cttgtaattt gttcagtgaa 6780
tagcaagcat ataacaacca gacggctaaa actaccacac cgctaccaca catgtttctt 6840
tacgtatcac atctgcattt ccccttgcct caagcatagt acttggaact ttgttcctca 6900
tattttatga ctgccttcat ttttttagaa aagagttgtt actattatta tatgtaagta 6960
cactgtagct gtctttagac acaccagaag agggcatcat gtggttgctg ggatttgaac 7020
tcaggatctc cagaagagca gtcagtgctc ttaactgctg agccattttt ctagctcaag 7080
tgcctttgtt ctttttctgg agtttctgga tctagacagt gtgccttaat tttgttcttc 7140
agtgatgttt ccagcctgca accgagcttc ccttcctcgg ctggaaaccc atctttgcct 7200
tctagattcc tgaagaggtt gaatttcatg tgctgactac aggtcccttc ttcaaaaccc 7260
attctgccct cagaatctat gaacccgatt taaaaaaaaa aaggattttt atttttatgg 7320
gtttggctat tttgcctgta ttcatatctg tgcaccacat gcatgaagtg cttgcagagg 7380
ccaaaagagg gcgccagata tcccggaact ggagttacag atggttgtgg gccagtgctc 7440
tggaaaaaca gtcagtgctt ttaaccccta agctatctca ccagccctca tcttctctta 7500
gaccgagtgc tagggctcaa actcagggct tcatgctctt gcagcaggct ttgtaccaac 7560
ggcactgtct cctaggctcc cttctatgtt tttgtttatt ttatgccgaa cacatgtgac 7620
atagtataca tgtggaggtc agaggtcaac ttcaaagaat ctactccctc cttttatcac 7680
gtgggtccta gggattgaga agtcatctgt gatttttgac ccagctgccc tacctcattt 7740
tgcagggaac agggatgggg atgggaatgg caaagggcag gacactgttc caccttccgc 7800
ctcaaggctg ttaacaaggt ggtttaatac tgaattgcca gcccagccca gcccagcctt 7860
tcactatttt cccggtattg tcaaacattt cctccacact acctatagaa tattcttact 7920
tatgtttaat gatctacttt agtgtttatt ttaagtacat actatgttcc gttccttgac 7980
ctcgctgtac tttgtttatt cgtaaatata cttacccacc tgttgtaata aaaatgtcct 8040
tctgtccttc cttcctttct tcctttcttc ctttcttcct tccttccttc cttccttcct 8100
tccttccttc cttccttcct tccttctttt ctcccttcct tctttcctcc cctccttcct 8160
tctttcctcc cttctttctt tcctcccttc cctccctcat ttctttaacg ttcaaccaat 8220
gtttctttct cacgtttcct ttccaaggtc agttccgagg gctggacaac cacactaagc 8280
tcagcggctc cgcacatcct gccctcgtgg agcccatgtt aaagagaggt tggtggagac 8340
acgcaatgga cactggagac aacgacttag cttagtaccc taaaagtgaa tggaggatat 8400
gcaaaaataa gatagagggg agagcaaagg aatttggcgt ccagcgttag tgtgtgtgta 8460
ggagtgcgta gtaaagagca gaagctcgtt acgtgtgcag cggatgtgag agtctcacag 8520
agggaacccc cagcgctaag ttcctgaggc ttggtgggtc aaagaacaaa ttaacctcag 8580
catagttacc cttccataag caacaaattc tccaggtcca ctaagcctcg tgatcagcag 8640
cctgtacagt cacttatgag gaacttttat agggagaaca ggatgtgatg gtgtatttaa 8700
acatatgtat ttaaagatgg ctcagtgaat aagggtgctt gttgcccaga cctgagttca 8760
atccttgggc tccacgtggg ggaaggagag aaccaactcc tgatcctcca catgaatgct 8820
gacatgagca tgcacataag caatacatga gtctaatttt aaaaaaggaa aaatacctct 8880
ggttaacata taataaattg ctattctttt agatggttgg attcctaata cacaccagca 8940
cagagtgaac gcactgggta atgtacaata gcaaggtgac ttacatcaaa ctacattaaa 9000
tgtttaaaac agtgaaaacc tgaaaagcta acatttttgt ccaatgtgaa aaaaaagtct 9060
tatttagtag catgatatac acagaggtaa aaatagatat cagaaagtcc cccacatatg 9120
ctaatcaatt ttgttcttaa tctttacata tccacttatt tttgtgatat ctttatttta 9180
tgcataaggg tgttttgcct gaatgtatgc ctttgtaaat acttgcatgc agtacccaca 9240
aaggccagaa gagggcgtga gatcccctgg aattgaagct actgatggtt gtgaaccacc 9300
acgttggtgt tggaaatctg acccaaatgc tctgcaagag tcgccagtgc tctgaaccat 9360
gtccaagtta tctctccagc attatatatc cacgtttgaa gtagaggtac attgggcttt 9420
tcatttttat agtggttact taaagcatag tctatgctgt ttttaagtga cagaatgttg 9480
ttcattgtat ttaaaaaata tagacaaaaa tttaaacact ttaaaaaata ttatttttct 9540
ttatgaagat acatgctttt aaggggttct gttggagaat ttcagtagcg ccaacttaaa 9600
acaaatactt tattagggct gtagaaatga cttagaggtt aatagtgtgc actgctcttg 9660
cagaggatcc gagtttggtc cctagcaccc atgtcagggg cttacaacac aacctcctgt 9720
aactgatgct gcaggggatc ccaccccctc ttctggcccc tctcatgcac aacacacatg 9780
aggcaggcac agactgatgc acatatatgt gaattaaacc ccaaataaaa tcgttttcaa 9840
aagtccaatg aatgtcttga caatgctttt ataatcaatt cattcatgac aggtggttcc 9900
ctgtgtttgt gatttctctt caagctgcgc atcaaagcaa cccctccttc tccctccttc 9960
cctccctcct cctcctcctc ttcctcgttc tcctccctct ctctgtgcat gtgtgcctgc 10020
ttacctgttt gcgcaccgca ggcgtgcagg tgcccacgga gtgattaatg aattctttgg 10080
aactgggtta caggcagttg tgggcgatgt agtgtaaatg ctgggaacca aactcgggtc 10140
ccttggaaga gcagcagtgc tcttcacaga tgagccatcc ctcaagtccc caagaacttg 10200
tttctcttgc tcagcttgca ctctccaaga cttaggaaag tgcttagtga ataagctggg 10260
gcacaaaaga tgcggttata agaaggtgac gtaggagcct ctggcaagcg atgcagatgc 10320
caattctcac ttgtgttccg gtccctctcg cttttgtcag ttttagaatg ttctaggctg 10380
ggtttggtgc tgtcgtagca cagagaggaa acagcatgaa ggacaaccag gccagagata 10440
gttgatggtc tgagcctttt gtttgctggc ttcactcgct ccgctgttct aaagcttcag 10500
tcaatgggtc tatgttgaac cagtttccgc tgttcactac aaagatgcaa ttggaagccg 10560
agggagggag ggagaagctc tggagagtat ggctcagtgg ttaagagcac tgactgctct 10620
tccaaaggtc ctgagttcaa atcccagcag ccacatggtg gctcacaacc atctgtcatg 10680
ggatctgact ccctctgaag acagctacag tgtacttaga tataataata aataaatctt 10740
agaaaacaag tagctgaggg aggagttttt tacttgtctc atccagggtg cctggaggat 10800
gacggcgagg cgccactttg cttacctcac caagtgagag ggacaaaaca tagttttgat 10860
ctgcagtagc ttcgcggtga gcaccacatc tccacctagt cctccgctat tgtcggctgc 10920
tatgaacaga ccctgctgtc acctggccat ttatctccat ggtcctgttt aagctctagc 10980
ctattgacta aggggatgca agttgaagtg gatgtcccca cgtttgaaca cagcactaca 11040
tgctggtatc tgaaatctga gtcacatcta ggtcagtcac attttctaga tttatgagtc 11100
tagattttat ttttccaggt gtcttgtttt tctgtctcta aatgatgaca tccacccccc 11160
tgccttcccc ccccccccca cacaccatat accctgggta tggttatttg tagcaaaatc 11220
aatactcttg tacttgaata atttttttct ttgcattttg aaccaaggtg tttattcaca 11280
aaaggaagaa ttgtccattt gtctgtctgc tcagtctttg gcttagcata gggcatgtgc 11340
agaggctcaa taaaaatctt ttgcctcaat cagtacatgg cacatgcatt acctcagggt 11400
catatttgta aataggtatg ggtgtttgcc tacaggtgtc tgtgcaccac ttgcatgcag 11460
gtgcctgagg aggccagtag agggcatcag atctctggga actggagtta cagatggctg 11520
tgagtcacca tatgggtatt gagtacaaga gagactctgg aagagcagac agtgctctta 11580
gccactgagt catcactgta gcccgcatgc catattatta aggaggctga acaccaagtg 11640
attcagcctc gctacagaca agtagaaacc tgtctctggc ctccttaacc acaaagttgg 11700
ggggcttccc tcgacacaga agccagagaa ccatttgaca ccgttcctct gtcacaggct 11760
gtatcattgg tccattttcc acatgacact gtgcattcaa gcattcatct ctgcagatcc 11820
ctgggcagta tggcagtgtg tgtgtgtgtg tgtgtttgtg tgtgtgtgtg tgcttgtgtg 11880
tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtttgtg tttgtgtgtg tgttctaatt 11940
ggaaaggaaa tcttcacttg cctttaaagt gcagtgctac tatatttctt tgcaaatata 12000
tatacgtata tgcatatgta tatgcagatg tatacacaca cacacacaca cacacacaca 12060
cacacacata tctcaaagtt cctttcaggc tgaagaatcc attattgtcg ggccagtgag 12120
atgacagagc agtttaaggt atctgctgcc aagtctgatg acctgagctc aatccctgaa 12180
atccacaccg tggaagggga aaactgtctc ccacgagttg ttttcttgac cgccacaggt 12240
gtatgcaaat atgcatgtgc acgtgcacac aagcactaaa taaacagaaa gtttaaaaaa 12300
ttaaggtata tattatttac tatgtaagag aacatcaaaa aagtcttgag aagtacacca 12360
tgggagaaaa cacacctagc ccttcaaata atttgccctt ctagaaaaat cctgaaatag 12420
ccctttcccc atacagtagt agaatgataa cattatctca gagatgagca ggcgtttaag 12480
gctcagcgga acgggaagag agttgggttt ttcttcctat ttgttttgaa tagctctgct 12540
cccgggtcct ctgcttgccc agatgatctg tgaaatgggt gagtgagcag cgcacctccc 12600
cagcgcgact gttactgacg tcagcaagcc tcattagctg ctgtttgtct aaccaaaggg 12660
aacagcgggt ggagagaatc ttaatgacct gacttcccac actgcaggtg ccacttgcct 12720
ggtgtgcacg ctgagattgc atcagctgac taggcaaaca aggaacagtg gaaatgggag 12780
gcagagaaaa agcccaagag agactgccca gtgagtggaa ctcgctgctc catcctggga 12840
gagtgtagca gagatgtttg tgcgtggtgg agtgaggtcg actcaggttc acagctgtgc 12900
gctgctacat agtagttgag ggtcgaatca cttaaaggct ttagtcccgt tttcaaaatt 12960
aaaataggga taatgataga accttaggga gaaggaggga cacgtgtgta aatcacagac 13020
ctcattgtac cactggataa ctggcaggag ccactgtttc tgactctaca gtggagagaa 13080
gggaagagca atgattggca ctgtggacgc aggtggcaga gaacagctaa agatgacttt 13140
atatcctaaa ggcaagtggg gtagctgtga gttttaaaga ccgaaccttg cttcacaaaa 13200
ttgctcttgc tttcctacct accaattctg cgttctttct ttttccctgg cagcatctcc 13260
ccggcggact cagccttggc tacagcggag actcctggga aggaaatgtc cttccccagc 13320
cctaggcaca gtggttattg tctgttctca catcctgtga gccctgtagg cagaggaatg 13380
ccccagaacc acagcaactg tgcaaacatt tgaattccca cgggtagttt cccatcctcg 13440
tacccatgag gcttctgctc tctgtagtca gaagaacgta cacagttctc aggagcagga 13500
agtagagggc taggaatcat gggtgaggag cctagcatgt gtgtgaatac atccgtggaa 13560
aacgtttttg agggagatag tacagaatcc tactccaggt gaaataatga gactcttgct 13620
aagaccacgt acggatgacc caatcaatac acaaggaggg agttgaaaag gagaaaaggg 13680
gttggccatt aatttagcca acgtataatt ccacgtatta gcaagtaact ttaattatcc 13740
tatgcgccct cggttttatt ctccacagct gtaaatggta ataatacccc ctttgaacat 13800
ttatcatgat taattaaggc agtgttgttg aaacatattg aaagttacct aggctaactt 13860
tgtccaattt gccagctgct ttggcaaatc ctctgcactg gggctggctc aggctagaac 13920
tatcttccat ctgggtaaat ctcttctcca ttccagagca gatatcatgg cgggtagctt 13980
gacctcacag tcatgagaca actcaaacca tggggattgg caaatgaagc aagtccttgt 14040
tattgaactc tccactcaga aaaaataaaa aataaaaaca tattaatact acggaggatt 14100
ccagtgacac tcccttctgg gaaagacact caagagattt ttatgagcag tcagggcaga 14160
tggaagtcac aaggcaaaca cctcaaagta aaaaaaaaaa aaaaaaagat caacatacca 14220
gagcactcaa caagctgaca gtctggctgc ccatgctaga tgcttagaat acatgaatga 14280
caaagtttgt atgcagtctc tgcctttagg gactttactg ctaatggggg attgtttatc 14340
aaacctaaat aatatccttg agggaatatt actatactgt gggtattagt gttcttaacc 14400
aatatgggtg ttgactttgt ctgtgtctct ctctgtgtgt gtacaacgtt tgggagtcaa 14460
ttctgtcttt ccaccacatg ggtcctggct atcaaactca gtctctcagc attactggaa 14520
gatgcctttg ccccatgagt catcttgaca gcaaaattgg gtattgagaa cttgaaagtt 14580
tgctgtgtga agaataagta aaacatgcta aaaaaaaaat aaagtagaca ggctgcacag 14640
atggctcagc agttaagagc actggctgtt cttccagagg acccaggttc atttcccagc 14700
acctacatgg cagctcacaa ctgtctgcaa cttctgttcc aggggatcca actccttcac 14760
acatgcaggc aaaaacacca atgtacatac aataaaaata aataagttat ataaaaatag 14820
gcaatctcat agttttacca tgttaattat atgttaaact agcaatgtgc atatattgca 14880
ttaaataaaa atgattcctt aactaaatta atttctttaa ttaaataaaa tgcaaaaaaa 14940
tgaatgaaat aaaatcactt tcacaaggtg gagaaacact ttgggaagac atccagatgt 15000
gaacctcagg cctccacata cacaaacatt aataagtatg ttaattaaaa ttaatttcac 15060
tttactttta aaaatagaac tactagattg tttaggatag aatatataac ttctgcccaa 15120
tatttgctca tattcttttg gaaaatatgt gttcaaatcc tttgcttatt cttaaattag 15180
attgcttgct tttattgttg tatttttttc tatcccaaat agccaaatag tatatttgtt 15240
tggaggtgta tgtggctgtt ttaagacagg atttcttttt ctttttcttt tttttttttt 15300
tagctctggt tatcctggaa ctcactctat agggcagatt ggcctcaaat tcacagagat 15360
ctgcttgctt ctgcctcctg catgctaggg ttaaaggatt gcactggtgc tgggcatgac 15420
aacccccccc cccctttttt tttaaccttc actggtatag tacaaatatg gcacacagac 15480
cattcaccca tacacataag agaaggacta aacaaatatg tttaaacatt aaaaaaaaaa 15540
aaactattgg aaacggaatc gtcaaactgg aatggtggag atttcatcag aactggcttt 15600
gttcattttc ctgtctccgt caaactgtct gctctgtcac agtctggttc tccaccacgt 15660
ggctgctgct tctgttggtt cagatccctg ctccgcagtc tgagccaatg aaatcccggc 15720
tcttcacaaa ggcggtttta gtggcaagtc tttggggctt cttctgttct cttggaagaa 15780
tggccccagc agcttcttcc atagcgcttc tggtgaacca gatggcatct tgttcaacct 15840
cttactgcac tgagcacgca gcctcccctt acaagattca taccaatgtc tcattgtttt 15900
ccaaagtaac ttgagacttg aactttccca gactctcaaa taaaaccatt ccttgtggaa 15960
gagtgcggtg gtctccagtc tttagagact gcctgcctac ctaagcttta ggggacagag 16020
tgggacaaca ctaacaaggt gtgtgggcat gacaacctct aatcttctca gctagcttca 16080
cctggaatct cagtcttatg agtaatctgg actaacagta agggactcat tatttgatgc 16140
ttgccacatc tggggtcaaa tcttggcccc tagaaatggg agatggatgg acaaagatgt 16200
cctatacctt tagctatacc ttctaagaat tcagcctcaa cagcttggag acagacggga 16260
ggacaaacag ggtgggcttc cctggttgct gggcccgctt agggcttggc tgtaggctga 16320
aagggaaggg agcttgctct ctcggccaca cactgtactt gcatctccat cgctgggatg 16380
cagacagtga agagaacaga ccgtagctct gcttgttctg agacatagga aagcgctcca 16440
acaaatgttt cttcacctat cgtatgctct gaggacaatt tccacagact ctagatgatc 16500
atcgttgcac aatttttagg aatcttcgca gtttccttga agtgtgtcct caagagttcc 16560
tgatgctgcc gttatagaag tgggagtagt tgggggtttt atagacaaac tctaaaacta 16620
aaagaaggag atatacacag ttacagaagt gtttggtcag caaggagtca aaaaattagc 16680
cagtgcacac taggcagcat attaaagtat ataatatagt atatattata tactatatat 16740
attataaagt aatgtattac aaagtaatat attactatat attataaagt aatatactat 16800
aattaatata taagtaatat actataacac atataatata taacaaatat aacatataac 16860
atgatatatt atattatatt atagtatagt atagtatagt atatataata agatactact 16920
ggctactaat ccatccaaat ctagaatgaa ccctgtgtaa acacacagga aaacagtggg 16980
aaatctagta gaaaactgga caataggtat taataggaaa ttcacagaag gcaaaacttt 17040
tcaaaatgac aagttcatga atggggcttt atcactatta aatcctttaa aatgcattta 17100
aatgccaagg cgatggctca gctgttaaag agcttgtggg gggatcagga ggaccagaga 17160
ttggatccta gtatctgggc caatgtcaga aggatgtggc agcctgccta taatgctagc 17220
tttggaaggt ggagtcaggg tatccccaga acaagctggc tcgtgggatt agccacattg 17280
gtaagctctg ggtttaattg atagagcctg aatcaatgaa gggaggagag agtgacacaa 17340
agagactcct gatgtcaacc tcaggactct cttcatgtat gtggacacat gtgcatgcac 17400
ccacacacac gtgtgtccac atatttgaaa acagatattt acatacaata cacacacaca 17460
cacacacaca cacacacaca cacacacatt caaagtaagt aagtgcataa aaatggttac 17520
attgtagcag tttgtatatg cttggcccaa gggaagtggc actattagga ggtgtggcct 17580
tgttggagga agtgcatcac tgtgggggtg ggctttgagg ttcttttttc cattttctct 17640
atttgatttg attactacag ccatgaaatt atgatgatct acatatacag attttatgac 17700
aagaaaagaa aaattcataa aaattttgaa gctggagcag tgattctgtt ggtaagatgc 17760
ttgtaagctc tgggctcata tccacttatc agtgagtgca tatcatgtgt gtccttttgt 17820
gattgggtta cctcactcag gatgatgcct tccaggtcca tccatttgcc taagaaattt 17880
cataaattca ttatttttaa tggctgagta gtactccatt gtgtaaatgt accatatttt 17940
ctgtatccat tcctctgttg aaggctttga ggttctatgt ttaagctcta ctaagtgcag 18000
aagaaagctc tcctggttac ctttggatca aaatgtagac ctctcagctc cttctctagt 18060
accatgtctg cctgcatgcc gccatgcttc ctgccatgat gataatggac tgaacctctg 18120
aacctgtaag ccagtctcaa tgaaatgttg tccttcataa gagttgcctt ggtcatggag 18180
tctcttcaca gcagtaaaac ccaacaaata tcactaagca atttttaaaa ataaagctaa 18240
gggctagtga gacggcttgg cggttaggaa tgcccgctgc caagcctgaa gacttgatga 18300
gtttagtttc cagaatttat atggtggaag gagagaacaa actcttagaa ctgtcttctg 18360
accttaacac acactgtgtg ctacactcac gcctacacaa atgcatgccc acgtaaacaa 18420
atagatgcga aagtcaatgt aaatacaatt ttttaaaaaa aaatgaataa catgcagtta 18480
agatgaggtc atattatact ctcaccattg gacaaaactt atatgttatt gtcctcattt 18540
ggttctgttg ctgggataaa atgcagacca gaactaacct gtggatgaag gggttcattc 18600
tgtttatagt ttatcctcct tcactgaggg aaggaaaggt ctacatcacc cagaggaaga 18660
actgaatgaa gcaaagacca tggaggaatg atgcttactg gcttgccccc aggctcaggg 18720
tcaacgacct ttctcatgcc tcccatagcc acctgcccag ggatggccca gctcacaatg 18780
gcctgggtcc tgtcacatca atcaacaatc aagaaccttg cctcacagac atgcccacag 18840
gccatccctc aaccaagatc tctccctccc acatgactac agtttgtgtg aagttggtga 18900
aaaccagcta gcagtttatc aaatcttggt gggaaaaaga tagagagaca gaactacgct 18960
ttgaggagca acttggtggt actaagtgaa attaagtata tataattatg gctaaggaaa 19020
taacattctt gggttaatac cttagaacat cttccataaa caaactagag gaaggtaatt 19080
taaagcacaa ataggcaact aataccatct taaactaacc tacacaccta cgggttatga 19140
atggtgacca caggctctgt atgtctacta agaaataact atgtgagtca aaatgaaaga 19200
accaatcgat ctacatacgc cagcaaggac ggtttctaac tgtgcttcgg atcgtaaaga 19260
taacaaagca aaattagatg atagcatatt aaaggttatg taacatgtga atataatggt 19320
ttctgtggtt cattgttaca tccgtttatg aatgaagctg tggttggtga atggtatgca 19380
ttaggataat aagcgtgggt acctggtaag agaagagatg aaaatggctg gaggaggcag 19440
tgattacagt tccattcaga agggaatcta gagcctggga gatggcttgg taaagggctt 19500
gccaagcaag catgaggatc gaagttcaaa tccccagtcc ccgtgtaaaa agctaggcag 19560
agcaacacat gctcagagcc gaggagtcag agacaggcag atctctggag tgcactagtc 19620
agctgactca gctgagtccc tgcactccag gtttagggag acactgtctc aaacaaacaa 19680
acaaacaaac aaacaaaaca gctggaatgt atgctgactt agttttactt gacatagcta 19740
gagtcacggg agaagaggaa acccccaatt gtgaaaatgc ccccactaga ctgacccatg 19800
ggaaagcctg tagtgaattt tcttagtgac tgctgtgaga aggcccagcc cagcatgctg 19860
tgagtgggtt gtcctgggtg ctgtaagaaa gcagactgaa caagcatcgg gaggcaaaag 19920
ctgataagtt gtcccttcct gtctccaggt tccttccctg atgtccttca ctgatggagt 19980
gtatctgaga gttgtaggct gaagtcaacc ctttcctccc caagtagaca ggaggttaga 20040
aagatagccc tgtgggtcag agtgggtgcg gtacaaatag gaggatgcac cttcatatct 20100
caacctttgc atgagcatct gggtgtagac acacttatgc ctgtgacacc tccttggagg 20160
tggtgatcgt gggactgact ggccaccagc ttagtttcag gttcaataag ctaacctgtc 20220
tcagggaagt aagatgagga gtgagagagt ctggaacacc ttctctggca tttgcacgca 20280
catatggata cctctccaca tgcttataca gtacatacat acactccact ggcatgcaca 20340
cgtacacatg cacaccaaca acaaaaaagt aagttgaaaa aaattaaaga aacactccat 20400
gttaacttat ggcctttaca tgcatacata tatatgtgca cacgcacctg catacactta 20460
cacagaggga gagattacat aggcgttgtc agcagtgtgc tgcagacaaa gaggtatgat 20520
cagtctttct gagatgaatc ttagtgatga ggattccatg atgtatgagc aacagggctg 20580
ggcagtgcag ccagctggtg ctgcatctcc tttcagtttg gattatctta ttgggtcaca 20640
ccagaaccag ggagataaat agtcaagaca gactttgaaa attcatacac cacacacaca 20700
cacacacaca cacacacaca cacacacaca cacacaccaa taaagctagg tttgaatgaa 20760
ttacttttgt aaaatccagg tctgagttgt attctgaaag ctttacttgt ttggactggc 20820
cagtagctca gtcaggcaaa aagacaccac acgggagggc agactttaaa gaagaacgtt 20880
tcaatgaggc aagctgtcac ggcttgtgtg aattacacaa tgaaagggaa aataaaataa 20940
aactatggcg ggctaaaatc tgtaagttct gacatgtggt cctcgtggca ccatctgctc 21000
atgaaagcat gaagaggctt ctggaacttt ccaggactgg gttgatttgt ctccacaaag 21060
ctgcctgggt aagaccctgt ggcactgggt catcaagaag gtactagcag acttcctttt 21120
tatctcagta tttttctacg tcagtcccca aaccatgaaa caacagggct taccctgcca 21180
caccaaaggt caaactatgt tttctcttac ccaactattg cctgggatgg ctccaacttt 21240
attactaccc cacctccaac ccgtaataac tctccagctc tcacttcaaa tccaagagag 21300
tgtggactga gtgaggggac cagagacagg tgcatctggt agaaagttat actcaattaa 21360
ctaactgaat gcatttgcat gtggttttaa ttccactgtg cagcaatttc ctgagtaaaa 21420
atggagagat tatatctagt ttttgagtca ctgtaagaat taagtaaacg tagctctcaa 21480
tctatatctg cacattattt ttcctcgtgg tcctagattt ctcttgttcc tgaccatttg 21540
tcccgtcttg gaatttcccc agccttcaga ggtgtagccc tataatttac cgtccagatt 21600
gcaatccctc ttcatggcat gaattaagtc ttatctcacc aggaagtgct ctttcctttc 21660
ttctgactcc tctccctctg gctttcctct tcatttcttc tctacactgt ttagggaaag 21720
aggtttctta gcaaatcctc agacacccca actagtgggc ttcccggaaa gtctcagccg 21780
tgtgtgggag gtctgccctg aagaagttct ttgccagaaa atgaagcaag gtgttctggc 21840
tggacagtga gggtggtaga ctgtaataag tatgtctggc tttaactctt ctatattcat 21900
ctgaggggag catctgagcc caacacaaca tctccatcgt caatggagaa tcctactcag 21960
ctgacaaggc ccttgcttct gtgttgaagg attacagcaa tggcctcctg tttattgacc 22020
tcatacttag acccatgagg catgcatatc atagtttatt tctcctactt agcaactgaa 22080
aatactaaag ggagtcacag agtctgactg ctctcacggt ctgtatctat tgcttaatcg 22140
aaagcttccc tgttaccctc ccatagcaaa taagggtcca tcccacaaga cactgtggaa 22200
acgcctcctc tcaagctcct ccagacctcg cagtgagtca atagagagca gaggggtctt 22260
acgtctctgg tgcctaaaga ggatggggtg ggcgttaggt ctcagcaaga acatctcttc 22320
ttatgtggcc agcggagagc ccagaaatct taagcttttt cataagggtt tctttgagac 22380
gcttcctaac ctagtgatcc ggttatcacc aagctaaggg aaaacgatca cgtgacacga 22440
aggatgaagg aaaaccctca gattcctcct cctctgaatc tgggagtgga aaactgagga 22500
gctgagctca gagttccaga gccacgcgaa gctgggctca gcagtgtttg cagctgcagg 22560
tctggtgagc ctgtggaaag agagaagggt gagagaagag agtctccaaa aagctgcccg 22620
aattagagaa acaagagacc ctgcctcaaa aaggcagaca cctcaagtgg tcctctgact 22680
tctgttcatg tgtcatgaca cgagcatccc tgaatccaca tacacagctg agaagcgtgt 22740
acacacacac acacacacac acacacacac acacacacag agagagagag agagagagag 22800
agagagacag agacagagac agagagacag agagacagac aaagagacaa agagacaaag 22860
agagagaaac agagagtggc tgaagggagg gggcagggga aggagggagg gggaggggga 22920
gagacaaata atttataaaa ggaaaatcat ttaaaacatt tcagggctgc cgagatgacg 22980
cagttgcaag caggaagccc tgagtttgga gccccagaac gcatccaaaa gccaggtgtg 23040
gagcgtgtgt gttctgtatc tcagctctgg aaacaagggc ctcgccatct attgccaatg 23100
ggctgccaaa ccaacaagga gcgagcaagc cccacttttc acgtaaaata cctcaaagag 23160
aaaagcaaca gatgcaaagg ggagagaatc tcgcttttgc ccagatcatg tagcagcccc 23220
gctcttagag gacgtactcc atgtctatgt gacttcaact ttcaattcta caaaaagggt 23280
tggtttcatc cctctcttct caatctggaa acagttcgtt ttaacgacag atgggtgata 23340
ttacacttag aatcaaactg ttaagccatg tgaatgaatt tatggtcacg tcatttcgaa 23400
gcgtcccctc tacaaccccc ctccccccgc tgggaaaaga ggggcttccc gctttcccag 23460
gaagggaagc tgtgggctct gctgggggac acacactgag ggactttcat cagcatccct 23520
cccaagaggg aagggacatg tctgtgggcc ttatggtctt caaagggacg taaagccgtt 23580
gcattctgat tagtttgtgg agggtacttg tttcaatcca gctacagttt ggtttgtgca 23640
gctggtatct gctgagcagc tgccgggacc tgtgtactct cgaaatcggt gaggctaacc 23700
cctgagaagc agagggtcgg gtgtcacgag agacttttct ttcccttttt ggcagccata 23760
ttgaaagatt cacagacacg ctcttaactt atccatgcaa agtgagactc tgctcacatt 23820
ccctgatact ttccttcaaa atgcaccagg aaatgtcagg aaataattca attagtctca 23880
ggaaatttac aaactgtgca aaacgttttg aatccacttt tagaacactt tcaatgacca 23940
caaaagctga agaaagggca gaaagaggca agggaaagag gaaaggaaga aaggaaacaa 24000
acaagcaaac aaatccagtt tgtcttcaga aggattatgt tggaggttcg ttttgcttgt 24060
agagactagt tcatctattc caggcttgct ttgaattccc tgtataatgg agacaggccc 24120
tcaacttctg gtccttcggc ttctgtgtgg cattacagtt gagtgctatc acacttaatt 24180
atgtcagagg cgtttttgtt tgtttgtttg tgtttatgtt ttactttagc agtggctgga 24240
gttggggtgg ggttgggtta ctccagcagc tcccaagagg atcagccttt caggctgtcg 24300
ctggaagggc agctatatag atgctgcaag aaaagcaact agctcctgct cttagagaac 24360
ttttgtttat tattattatt aatttacttt atttacattt aaaatgttag cccctttcct 24420
ggtttcccct tcgaagaccc cctatgccct ctcccctccc cctgatcacc aacccaccca 24480
cacctgcttc ctggccctgg cattccccta cactggggcg ctgagccttc actggaacaa 24540
gggcctctcc tcccattgat gactgactag accatcctct gctacatatg cagctggagc 24600
catgagtccc accatgtgta ctctttggtt ggtgatttag tccctgtctg ggggtactgg 24660
ttagctcata ttgtttttcc tcctatgggg ctgcaaatct cttcagctcc ttgggtactt 24720
tctctagctg cttcattggg gaccctgtgc tcagcccaat ggtaggcttc gaggaaccac 24780
ctctgtattt gtcaggcact ggtggagcat ctcaggagac agctatataa ggctcctgtc 24840
agtaaggtct tgtactcagc tattaaaaag aatacattta tgaaattctt aagcaaatgg 24900
atgaaactag aaaatattat cttgagtgag gtaacccaac cacaaaagaa cacacaaata 24960
cgtggtatgc actcactgat aagtggatat taggccagaa gcttggaata cccaagatac 25020
cattcacaaa ccacatgaaa ctcaagaaga aggaagacca aagtgtggat tctttgatcc 25080
ttagaagggg gaacaaaata cccatgaaag gagttacaga gacaacgtgt ggaacagata 25140
ctgaaggaat gaccatccag agactgcccc acctggggat ccatcccata tacagtcacc 25200
aaacccagac acttttgtgg atgccaacaa gtgcttatgg aaccttttat ctatagagaa 25260
ggtttctcag ctttggtagc attaattaat tcgttgtcat ggaaaggtgc cgtttacagg 25320
catcccttcg cctctccctg tagttgccag aaacatctta gatatggatc aatatcttct 25380
ggggccagga gatattccca aattgagaac cattggtcag cactctgtct atcatgactg 25440
caaacaaatt gaaaacttga caaacattaa tgaaaacttg ataaacatta atgaaaagaa 25500
actcagaaaa cactttgata gtattttctt taagacatgc catgcgtggt ggcgcatgcc 25560
tttaatccca gcactcggga ggcagaggca ggcggatttc tgagtttgag gccagcctgg 25620
tctacagagt gagttccagg acagccagag ctacacagag aaaccctgtc tcaaaaaaaa 25680
aaaaaaaaaa agacagggtc tcatgaaacc cagactggcc ttgaactcac tatgtagctg 25740
tactgcctgg gtttgtgtgt caacttgaca caagctggag ttatcacaga gaaaggtgcc 25800
ttccttgagg aaatgcctcc atgagatcta gctgtaaggc atttttttca attagtgatc 25860
aagggtggga gggcccattg tgggtggtgc tggactaacc tgggctggta gtcctggatt 25920
ctgtaagaaa gcaagttgag caagccaggg gaagcaagcc agtaagtaac acccctccat 25980
ggcctctgca tcagctcctg cttcctgacc tgcttgagtt ccagtcctga cttcctttgg 26040
tgatcaacag cagtatggaa gtgtaagctg aataaacccc ttcctcccca atttgcttct 26100
tggttatgat gtttgtgcag gaatagataa cctgactaag acagtagcca acgatgatgc 26160
tgagcctctg attctcctgc ctctaccttc tgagtactgg atttacataa gtgagctgtc 26220
acaccagttt atatggtgct ggaatcaaac cacaaaggct cccagcatgc aaggcaagca 26280
ttctctcaac tgagctacag cctcagtttt agcaatgcaa agaagaggaa aaggagggag 26340
aagatatata tatttttcat tacatatatc tcacatatat tttacattac aaatatctca 26400
catatatttt aaagcgctgt agtggtgaga tattgggctt tgtagacacc aggcattctg 26460
ctgtcctggt tcttcaggct ttatgatctt gaacaccata gttctatttg gtgagtctgt 26520
tttctcagga gttgttgact atgcctttag tccagtgcta tctgaagaat gaagatagta 26580
tctctctcag tacacctttg gcaagggaag ataccatctg cccagtatca tcatgtacat 26640
tggttgagag ttaactctgt gctaagtgtt gtggtaaatg cattatttct tattccatcc 26700
tcatggcaat cctaccaaat gtcaaaaatt attatccaca atttgtagat aagaaaacca 26760
aaactttgac acattaaatg actgtcttag gattttgttg ctgggaagag acaccatgac 26820
caaccaaggc aactgttaca aagggtaaac atttaattgt ttctctgagc acttctgtct 26880
tccaggattc taccacaatg gcctttctgc tctatttaca gtattcaact gtttttttag 26940
tacaaagttc caaggtcgtc cacagtcctg caaaaagcaa cacaatcagg tacttcccag 27000
caacggcgat tcttgagtat cgatttctgt attatttaat cttctgttgc tgtgataaaa 27060
tgccacgact aaggcaattt acagcagtaa gagtttattt gggcttacat ttgcagaggg 27120
ataagcgtct ctcatggtag ggagattgga aggcagtgag tggggcctga cagctggaat 27180
aggaagcaga gtgatcacat cctttactgt gaacaggaag cagagacagc aaacagaaaa 27240
tgggctcaag ctaagaaaag aactctcaag tccagccgcc agggatgcgc ttccttcagc 27300
aaagatgcta gctctccaac agcatccacc atctggggaa ccaagtgttc aaacacacgg 27360
gtctgtgagg aatatgcttg accttaacaa agctagggaa atgtgtagac tcctctacac 27420
agctggaaga tgttcactct ctcttctttc ctttaaacag tttcttaaaa attatataac 27480
ccactcatat tttcctaggt gttacaatca taccttacct ttaatcacat tttcatttat 27540
ttgtttgttt gagattttat gtttaattat gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 27600
gtgtgtctgt gactttgtgc acatgaatgt ggtgcccatg ggagccacaa gaaggcatca 27660
gatcatttgg agctgggaaa gcagagccgg aggcagggac atctggcaga gttcagagtg 27720
gacatgacta gactgagctg ggtcatgtgg ggagatgtgc agaggaaggg aaaggggaga 27780
gatgggaaca aggtgcggca ggcaagagag caaagataca cacacacaca cacacacaca 27840
cacacacaca cacaccacat atgtacatat acacatacac acatgcacgc acgcacacac 27900
acacatattt agatgcattg aaatcatttg atatacaaat agaccatgca aagatcaagt 27960
cagtgtgatg gacatttcca gctgtttaaa ctttttaata cttgttagta ttgagagtcc 28020
cacccccacc ccatttcact gctttacaaa gatacaaaac attgttctgg gcatgttggg 28080
tgcattcctt aatcctagtg atgcagaggc aggcagatct cggtaagttg aaggctatcc 28140
tggtctatac agtgcattcc acgctagcta gggctaccag tgagattgtt tcaaaaaaca 28200
aaagtctgta gttatcttcc tatattgttt attcttctct gccttcctct ttttctgcac 28260
acctgtcttc tctgacactg gtcagcatgt gtgagtgctt gggcccgtta atttgtgtga 28320
gcagacatgt gtcaacatca cttagaggaa aggtggcaga ctcattaaca cacacgatta 28380
acatgattag gaccagtttg aaagcagcag ttctccatct tcctaattca ggcctgactg 28440
tgtcaggact ctacactctc tacactgttt tctcagctaa cttgtccttc ctgtctctca 28500
cctcttcccc acactgacac acatgtatac acagcccccc caccacatac ctaccccccc 28560
cctacaccac agacttccag agagagggag gtggtgacta cgctgtatgt gtttaactgt 28620
tacctgtctc tccttagttc tgaatgaaat ggaatctaat cttaatcctt tcctgtcatt 28680
attagattca tggagtccta acggccagag tctctagatc ctgtcttatg aaattcaact 28740
ctcatacaaa attcaaagta tcagtttcag agaaagttat ttgaaaaaaa aaactgtgga 28800
gttgaaagca attgaggctt attctggtcc tcttactcag tgtgtgtgtg tgtgtgtttc 28860
tgtgtatgaa tgcatgtatg catggggtat acatgcatgt atgcatgtgt gttcatgttt 28920
ggtgtatgca tgtgtgtatg tgtgaggtat gtgtatgttt gtgaggtgtg tgtattgtgt 28980
gcatatgtga gcacatgtgt gtgtgtgtgt gtgtgtgtgt gtgtatgcat tcagagacag 29040
agtgtgctca gcttccagta gatcctcagc taggaggtgg tatcttgtga gactcttccc 29100
tctgcatgct gaactgttga ccggcttgac ctgtgaaggt cttgtgcagg caaccacagc 29160
tgctgagagt tcatgcatgc aatagtcttc atgtttattg tagttctccc taactctggt 29220
tcttaccatt tttctttcta gtctgtgatg ttctctggat cttgcaggac aggccataat 29280
gcagataccg agttttattg atgtcaatgg tccactgggc tagcagcctt actgactctg 29340
ggatagatgc tgttaaatca atgacagtgg ctttttaagt tacatccaga cgttaggcag 29400
gaatagataa ctcagatata acacgaaggc ttacccctgt gtttttgatt ttaaaaaatt 29460
gtgagtgtgt tatacgcagg catggttatg cacattgatt tgtgtggttg tgggatctta 29520
tgtcagaggg acttagatgt cttcctttat tactaccgat gttattcttt tgggacagga 29580
acctggactt catttctttt tgccaggaag tcagaaagcc ccagggatcc tcccatctct 29640
tccttcttaa tttctgggct tctgtaggca tgagcaaaac tatgcctggc ttgttaggtc 29700
ggcactggta tctgaacctt tgcttccatg gttgtacagc aagtgttctt aactcatgag 29760
gtcccgattt ttttgtttta cttaatgcta tgttgtactg tattatatta tgttttgctc 29820
tctctctctc tctctctctc tctctctctc tctctatata tatatatata tatatatata 29880
gactggcttg caccatggag tatgtgtcag tcaggagata ccttttggaa gacagtgcct 29940
ttaaaccatt gaaccatttt tctgcccatc acaaattctt tggactaaaa aataagagtt 30000
tctttttcct taacaggaca aaactttatt ctctgatatt taaaatataa gagaatattt 30060
caaaatttca aaaaccagtc ccttaagtta aatcaagtgc ctgctccttc acatctctct 30120
tctcttttga tgtaagcact tattgatcta aactcacttc ttgaaaactc ggagcatctc 30180
acaggcttcg ctatgttgcc tctctacttc catttgcctc aagataattt ttaatttctc 30240
ttttaactat ttcattagcc tattgattat tgaggaccat gtcaaatttc ctaggttttg 30300
tgcccccctc ctcaccggag actttgaaag aatgtatgtg ctgcaaatga caacttagtt 30360
tcttgaagtt tattaatttc tttatgcata tgtatatttt gcatttattt tcactgtttt 30420
gctcaatgtt tgtcattgtt ctagtttcct ttctgttgat aaaacactct gaaaagcaac 30480
tttgaagaga aaaggacttg tttagtttgc tcttccaggt cacagtccat tactgagaga 30540
agtcaaggta agaactctag gcaggatgcg ggagccgtga gggagtgttg tttgctggct 30600
gactctctgg aatgttcaaa ctagttttat tatatagttt gagcctgcta gtctagggat 30660
ggtgctgccc acagtgggct gggtcctccc acatcaatca atcatgacat tttctatgag 30720
acacggccac aggacaatat gatcaaagag atctctcaat tgaaaactga aaaaacttcc 30780
tcttcaggtg aatctacgtt gtgtcaaggt gacaacttgt ccagtagtac taagcagggc 30840
agtcatcttt aatcagagag atgacagtat atattccctt actgtatggg tttgtgttga 30900
gacacctata atggcagaca gattaagtct tcctgcatct gctcagagcc cctgtccaaa 30960
cagttccttc ttccctcttg tctctccttc ttcagacagc ctacacaatt cataagcagg 31020
agaaaacatc cataggatgt tttccagtta gtgttctaga atttcagtag tagaaaggat 31080
ataaaaatta cttagaaaca gggagtactc aatggcaaag tgcttgcctg gcatgcatga 31140
agccttgggt ttatcacccc cccccccact cttagtccat atttatcatc tttcatttaa 31200
ggaagcttaa aataccagag gactagagag atggcttatt ggtaaagagc acttgttgct 31260
cctgcagagg accagggttt ggtttccagc acccacaagg tggctcacaa ccatcagtaa 31320
ctctagtcca ggatgtttga catctttttc tggcctctgt gggtactagg cgcacacata 31380
gggcatatac atacatgcag gccaaacaca aaagtaaaaa taaaaaatat tgtctaaaag 31440
ctatctcaga cacagggaag tgcagagatt tatcctaaac cacactgttg gttaatgtga 31500
aagtcaagct aagataaata aataaataag taaattaatt aattaattaa taagtaatag 31560
agggttggag agatggctca gctatttagg gtgcctgcag ctaggatgca tgttttgttt 31620
ccaggggatt gggggcatga gagaaacctt acaacctgct acagggaatt ggacatgctc 31680
tcatggcctg tgaggatact tatacacaga agacattctc tctctctctc tctctctctc 31740
tctcactctc tctctctttc tctttctctt tctctttctc tttctctttc tctttctctt 31800
tctctttctc tttctctttc tctgagacaa acacacacac acacacacac acacacacac 31860
acacacaaat aaaaacaaat cttggcttat ctgtgcatcc tttaatttca tcactaggaa 31920
ggaagacaga tctttacaag ttcagggtca gcctgatcta caaatcatgt tttagatcaa 31980
caaaggttat gttatgagac cctatcctgt ctcagagaaa caaaacaaac aataacaacc 32040
gctcccccac tcttatggta aaatgaaaag ttactaaagg taggacaccc aagagcacac 32100
gggacgagga tttctaggca agcatctttg tgcagtgttg cacctattat tgaccagcat 32160
tgtttcagga aatgttaggc agaatcaccc cgctgttctc ggaagcaaaa cagaggtgtc 32220
acaccttctg attagactgg ccagcttgct tttcaaatca tctcttcttt atcatcaaag 32280
agagaaggaa acctcggaac aatgctgtct ctgcaatgct atccccactc gatcttatcc 32340
aaggctgccg tctttgttgc catagccacg gagacctgat gcgcaggtat ttgatcttgc 32400
tatgtgccac tgaagggtgg atattccatc ggagaccaaa gaacaggagg ttgttaagtg 32460
tgttgtaggg aatcagagcc atggagaagt tgtttgatct gagtccaggg ctgagcagga 32520
cattggtaca tcctggatga aagctttacg gtttgtacac agcttggaga agtttaagtc 32580
ttggaaaagc cgggcagatc ccatgtgtta actcctccat tgctgccagc ctttccaagc 32640
ctgtttcact taacaaatat ttattgagcg aggtcattac ctccaatttt cactacggag 32700
acttgaaaat taagacacgt actctgcctt tgaggacctt tgaggcacac agatgtaaac 32760
tggccattgg ataatatcat acatgacacg tctgagacac gtgaggggaa agtagaaaag 32820
ggtctatgtc tcatacagca aatgtataaa gttctgtagg taaagtgcca tttgacatgg 32880
ctcctaaaag tccccaaaga tagatttatt tatttattta tttatttatt tgcacatgaa 32940
taatcaactt gttgaaggac tgagagacca cagaaaaaca agcaggagga atagcgacca 33000
tccaggaaag aggcttgact gggcagaagg gtcaaactcc aggagacaga agacaatttg 33060
aattaagatt agccaatctc agagattcct tatgaatggc ttgatgataa ctcctcagtc 33120
ttagccagtg ggaagttttc taggaggaat tctgattggg cagatcttta gccacatgca 33180
atgcccgagg gtagaagatg tgtcttctta ttctgggcag ccacactgtc agctgaaaat 33240
agggtgtgtg ggttgtcatg tggacagtgg cagttcctat aatccatgcc tacctgtgct 33300
gtagctgcac tccttgactt acacacacac actctctctc tgtttctccc ttcctccccc 33360
ctctctccct cccttccctc tctccttttg cagaggtggg tattgaaccc ccgacctcgc 33420
acgttatgat agacaggcac gtatccctgg gcgctatgct gtactattaa cgatttgtat 33480
ccctttcctc tggagaggag atggcgggct tttcaaaaga aagaaagaaa tattcttact 33540
ctatctatag tacccaacag tgtctggtac acctacatac acagatatgc agggcccgtg 33600
gaaacacaac aattccactc ctgtttaggc aacttttcat gctctttttt tccctctgaa 33660
cttggcttca tacagttttt agtgttcaac cttagtcttg ttaaatccac tccaccatag 33720
ctcagcctaa tcatcggctt ttgaatggat ttacagaact agacacacat ttcctcctac 33780
agagcagacc ttacgtccca tcagaaagca gttggttaca cccaaatgtt gtatggccct 33840
ccattaaaaa agatgagctt atttgtttta tgtgtgtgag tgttttgctt gtatgtatac 33900
atgtataact tgtgcatgcc tgatgtctgt tcaggtcagg agcaggtgtt tgctggatct 33960
cctggaactg gagatataga tactatgacc tgctatgtgg gtgctgggaa tcaaatccaa 34020
gttctctgca agagcagcag gtgttctttt tttaagttaa tattttagag aatttcatac 34080
acaaatactg ttatttacct cattaccacc ccactcaacc tggatcctac ccccaaccac 34140
tcccttctaa aatttatgac ttcttcattt cttttttgag atttatttat ttattttata 34200
tgcctaggtg cttctatcta tgcacccctt acacggctga tgctcaaaga ggccagcaga 34260
gggcgccagg tcccctggaa ctggagttag agatgacggt ggcttttcct ccctttttac 34320
caggagacct agtcctcaca gaggttttca ggtcagttcc agtttgattc cttcaagtcc 34380
tgtgtccaaa gtgtgtgttg tctttagcca tacgcgttta atgtcaagtt ctgggaggca 34440
ccaaagagaa cagcagaagc cgctgggact tctctgacca acagcacgga ggtttttcat 34500
acacggtact agatagtttt tggctcttgc agggagcatt atagcccaag ctggtgtaac 34560
accatttaaa gcacacgtaa gcagtatatg catatactta cacttgtatt catttatgta 34620
ttatgcatgt gttcttttta gagatctatt ataggtgtat gaatgttttg cccacatccg 34680
tgtacatgca ggacatgtgt atctgatgcc tgagagagtt agaggagagg gcatcaggtc 34740
ccctggaact ggatttacag acagttgtga gcagccacga gagtgatgga gactgagcct 34800
gtgtcctcta caagagcagt tactgctttt aaccactcag cctcgccccg ctacgcgtgg 34860
atttttaagt aaacacgaaa taaacttttc ctttcgcctt ttcaaactca ctttgtctta 34920
tttatgcctc ttccctcttt tccctctatt ttattcttcc ccctcccatt aaagccccac 34980
ccccttttct attcccccct ccctttttgc taggacacag caagtgctct taactgagga 35040
gcagtctctc tagaaccccc gcccacgcca cacatctttt agagctgaaa atttcctaca 35100
gcttccgaaa ggaagaatca ggatagagtt tagaaatata accaacagag gagaagatgg 35160
caaaactact gctgccttca gcacagagag gctttaccta gaaaatgggg ggggaaatgg 35220
aaacatggaa aaatgcattg attggaaata taccgaggac atgggaagtt ttaagggtga 35280
tgagcttgag gcgaggaaac cagatttgta cagttttgga agaaacatgc aaagtttaaa 35340
ttcggctggg gatcagaggc agttatttta tggcaaagat gagattggtt ttgtccagct 35400
tggcctcatt tgtacctctc cattttagct atagtcacat cttattaata cttacctcac 35460
tctttggagc ttaggcagaa aatccattat ttatggttga gtattcacca tttatgtgta 35520
agtaaggaca tctgtatgcc attgaatatg tggttgtgaa gtaattaaaa cagtttacag 35580
tgtaaaatga aagacatttc tctattttaa acatgcaata gagaaatggc attttatata 35640
ttgtttagaa agatttattt atttatttaa tgtatgtggg tacacactgt agctgtacag 35700
atggttgtga gccttcatct ggttgttggg aattgaattt aggacctctg ctcgctccag 35760
ccaaccccat ttgctctggt tggccccact tgctccatcc caaagattta tctattatta 35820
taaataagta cactgtagct gtcttcagac acaccagaag agggcgtcag atctcattat 35880
ggatggttgt gagccaccat gtggttgctg ggatttgaac ttaggacctt cggatgagca 35940
gtcagtgctc ttacctgctg agtgctgagt catctcacca gcattttata ttctaactag 36000
attcaataga cacttttgtt ttgttttgtt ttgtttgttt tttgtttgtg atgaagaata 36060
ctaaggggtt tttacttagt tagcagtaag caagatgaac tgaatatatt gtatcaagag 36120
gcatcgagat tgcatggctg taactcaggt ggtgatgaag gaggataacc atcccctgga 36180
ggctaacctg agctacacag caagacccaa cccaaaagca gccagccaac caaaccaaac 36240
tcaaacccaa aggcccgtga aaaattgaat tctgatgatt agtgccccat aaggacctta 36300
tggaacatga aaacaatagg aagaacaaag agaacgagca ggtcagaacc acacttaccc 36360
aaattaaagt ctcccagctt ggaagatcaa atcatacatt acctcaagta actcatattt 36420
gtctgcaagg tgtcagctga ccccttttct ttaatatctc acttcccacc cccaccccct 36480
tttaaacaga aagacctttg attgtggtgg ccaataattt gaagttttga agaattaatt 36540
ggccctatta tacatgaaga catagtaatc ccccttcact tttggaagcc tcggagagag 36600
tttgagaatt tcaagttgaa atatcacccc ctttcacaaa attctgtatt taaggatagt 36660
atttttcaga atttaaaaaa attttttact ggaaacttaa tattacagca ttccccttca 36720
gggtttatgg tcaagctttt ttaaatatat gttttatttc tttaactggc agatgtttga 36780
aagatgagag taggattaat cctcatatta atttttaaat acatctcatt cttccaaaga 36840
atgccgagaa aaagaaccaa ctctccatgt agtaactggc aaggaaggaa atagggctcc 36900
taccatggca actccctgtc agggatgctt agtgttgttt ctgtccaggt tcctcactgc 36960
tgagaacaaa tagccaacaa tactgagaga cggggaggtt tcttctggct aacagtttca 37020
gggatacagt tattgcagga gaggagagga gaggagagga gaggagagga gaggagagga 37080
gaggagagga gaggagagga gaggagagga gaggagagga ggcagctggt taaaccgggt 37140
ctgcagtcag gaagcagggg agccacacat aaatgccgag actacacttg ctttttcctt 37200
ttgctccact gtgagaacac agcagacctc aaaacacagc agtttgggaa ccaacacaca 37260
cgtctctttg tgtctggcaa ttgatgtaag ctccatggtt tttgcttttt ttctagctcc 37320
tttaattgat tgattgattg attgattgat tgattgattt ctgagactgg attttgctct 37380
gtaagccagg cttgtgtaga actccaattt tggctggcct ggaattggag aagttcatat 37440
tctcattata cagagtgctt aatggcaccg ttatgctcag gtcattcatt cattcattca 37500
ttcattcatg catgcatgca tgcatgcatg catgagatag gagttttctg tgtagctcag 37560
aatttccctc caacttcaaa ttctccttcc tcagctttcc tggcaatgaa aatacaggcc 37620
tgcgccatta tgcgcaagtt atattggctg ttgttaatat ttatgttagg aaaagaaaat 37680
agtctctgtt ttacatacaa tctacttgga atcatttttt ttttttaaag ttaagtcggg 37740
gtgaggggtg tgtgcaggtt aacaagcaaa cgcaattcct ccagctaacg ccaaggggca 37800
ccctctcctt cccctcggtt tctggagcgc cttgagttct ttccatctgc acaaagagcc 37860
cggcctcctc ccgggtgaca tcacaaaggg tcgttctccg ccccttcggc gccaccacgt 37920
gtgtccccga gctgagtggc catccgactc agtccctcgc cggccggtct aggcagcgga 37980
ggaggcgagt gcttgatagt ggctggaagc ttcgctatgg gaagtcgctc tttagcactg 38040
tcgcggctag ccctgctctc tggttctccg cagccgctgt cgttggagag caccgggagg 38100
cgcgggttgc gagcgcgcct gcttctcacc gcccgggcgc cagcgcccct gggcaggtgc 38160
tgagcgcctt tcggagcctc ccctgctgcc tccctcttcc gcctgggtgc ctggctgctg 38220
cagtgcacat gggctgctgg aggtagatgg gctcaccgcc cgtgaggcgg cggtggatgc 38280
ggcgctgggc agaaacagcc accaattcca gctgccgtgg ggccgagcgc cccgggcgcc 38340
gctgcgagcc ccgagctcgg ccatggggac ccgggcaagc agcatcaccg ccctcgcctc 38400
ttgcagccgc accgccggcc aagtcggagc cacgatggtc gccggctctc ttctcctggt 38460
gagcgatagg aggggaccct agggtggcgg ctacgttcga gcctgtgtcc gggagccggg 38520
cgggtcctcg ggcccgtagt gccggaggcg cgcggtggga ccagacgggt tggaagggtt 38580
ggttacaagg caatagccag accgaggagg actcctacta gatcgtgtgt gtgtgtgtgt 38640
gtgtgtgtgt gtgtgtgtgt gtgtgtgtgg tgagctaagg ctagtgagtg ttaaagaatt 38700
atttttcttg caatctggct gcttgaagga ggcgcgagag gtgtccgcct cgaggtcctg 38760
cgcatttttg ggtttttgcc cccgactcgg cctatctcgc accccaacac ccagcctcac 38820
cccaatatca ttcgctgcca gaccctcggc gcggtgcgag gcccgagtag tcctgtcagt 38880
agccagctgc cggttgtggc cgctcctttg tcgctactgc aatgtcatgt ccggatgcta 38940
ccgcagtgga gacagccgga tcggtgcgct ccggacgcga gcaaccgctg catgcttccg 39000
cgcgcgaagc tttccggagt agggcgcagg ccaccccttg cttcagcttc cttgcttctc 39060
tcctccctct tagttcagat gggtcctgat ttctgcaagc caaaagaaga agaagaagaa 39120
ggagcccggg tgggtggtgg gggtggggtg ggagggggag gaggagaaga aggacccaga 39180
gacccaggcg cctctaaagc acaggcttgg agccaaccgg cgctgtggct ctcagtcgag 39240
ggggagggga aagagctaca taaaggacga ttaattttcc ccatcctttt cttatttctc 39300
cctttctgtg tttagacatg tcaccaagca agatgatgca ggctctctca gcacccaaat 39360
ctggggcgtg cccggattgc aatcctccat cactttatct gatcaaaacc tgacatcatc 39420
ccttatccaa aacttacccc cagctggccc tttatttcca atattggggc caagtgggga 39480
attaggtgga agaaaatttg aattcaaacc cttgagatgc tataaaccaa tcatgtcttt 39540
catccctgca gggaggatga aggttgttag ctaaaaacta aacaaaaaca aaaaagagct 39600
tgttttcatg gttgggctgt gtaagggaag gcaggcctct tgtctccttc ctctaaaggg 39660
cttactgcct ggccagccaa gatctactgc ttccatccca aggcatgaca gttgctatgg 39720
cctgggaatt cattctacag acattctggt tctctctgtc tctctctgtc tctctctctg 39780
gctgactctc tttctgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg 39840
tgtgtgtgtg tgtgtttagg gagagagaga gagagagaga gagagagaga gagagagaga 39900
gagagagaga gggctaaaga aagtttgttg ttcttagcat ttatgaggta aatctcagtg 39960
tcccttgaga gacgcttttc tgtcttttta taacaatggc aaagtccaag ccctttaaac 40020
aagtgtggat agtaaataat cagagagtct ttgggaccgt ggacttgaat tgacagtctt 40080
agattgaacg agttcaagga agcactgatc ctaatgacct gagttaggtc ccttgctgag 40140
ttccctccaa aggtcttaga cctgcttccg tgatgagcat atactgccgt gtgtccctgc 40200
tccacacaga tacaatcctt atacaatact tatagatcag tccactcaaa tccaatctaa 40260
agttagtgct caatgtatag tcgtaatctg gaattatttt ttaactttta gcctgatata 40320
taggtccttg aaggtctcag catagtaaaa ccatatgctt taagtaacca agaaagggcc 40380
tagttctttt tattaaatga tcaaactcaa tgtacccaca gattgcaccc agatttgcaa 40440
ctgatgacct acagtataag tttgacagtt tgatgaagtt tatgaaaggt attttagaga 40500
caatctcaag gtgacgatgc tacagggttc cttgatttcc tggtaactat ggcaaaaggg 40560
ctttctttaa attgatggag taggaggagg gtgagctgac catcctggag tgtgggaata 40620
ctccaggaaa catcaggagc tatgcaatga ccttctccat ccccactttg gacggtccag 40680
tcatcaggac gggccctgtt tctgtataca acagtgatct ggtgactctg ttctcaggag 40740
aattggtccc attggtaatc ttggccacat taacagcaga caccaggtag gacagctcaa 40800
gtaaacatgg tgtgaggtac ctagaagaat aatgggggat acaggaaggt taatgctatg 40860
tatatacagg gtggttagat aaagaaataa tgatggcttc caattgccct tctctcattt 40920
ttttttcata gcagtctttg ttgttttttg tggctctttt ttttttctat cagcatgaag 40980
agcttactat aggctctgat atgtatgcct atcatatgaa cttgtcaaaa gagcagcgag 41040
ctaatttata cagaatatgc cactatccct gtcaaacggg tgtcacctcc attctacgga 41100
tgagaaaata gtctccaaga atcttactgg tctgttgtag tatgtggtga ctctgggctg 41160
gaactccttg gctcctactc tctctcaccc acgtaccaca ctgcccgttt cacaacttca 41220
agttgtttgg tgagtgtaag gacagagaag gactgctggc aggtagctga gacggtggct 41280
tgattaattg gggaatataa gtgagacgtt cacaaggacc tttggagtga gtcagtctag 41340
ttgctggcat ttctattgct gatgtgttga tgtgaccgtg tcatgtttgg aagttactca 41400
caaactgaaa tgcagcatac acgttccagg ccaaagttct gtaaatgaga catttagatc 41460
tgtagtggtt tagggattgt cctagaagga cttgcttact gcaatgctgg atgcagtcag 41520
aggtgcctct tgcctttagg gagcttggtt tgactataca gatagactga ttgcaaggga 41580
tggtcaaggg aggaaagcaa cttccttggt aaagactttg gatttggagc tttggaaact 41640
gctgttatcc acggactgag aattcctgca ctgaaggcac agggaagaag gcatagcaga 41700
agaaggagtg gaaagattct aaaagccaga ggaacagaag ttgctgtgag atcgtgtcac 41760
ctggaaatgt ccgggaagct tcactcatga agtttcaaca gcatggctgc gtaagcggga 41820
tctgatcaga gaacaccagt ggacaggcta acacagaagg gggaacttca tagggcctca 41880
gccctagaca aaaaattaga aatatgggct actaaggaat atatatgtgt gtgtacaata 41940
cgtgcatata tatacaaaca tatgcacaca cacatatatg tatgtgaatg taacacatgt 42000
gcatatgtat tatgcacatg tgcacatatg taatagcaat tgaaaataac gccatgaatt 42060
tgagtcgtgc aaggctggta catgagaggt tggctgtcga gaggaaaggg aaggaagaaa 42120
agatttccac acaagaggtt gtccagctgt ctggccatcc cttttctagg cagctggcat 42180
ctcaccattt ctggtcacca aaagaaaaaa taccttattt atttatttat ttatttttct 42240
tttgccggtg ggaaatggtc agacacatca tcagacacat catcagacac atcatcttgc 42300
ttagagggtc ccaagtgtta ctgttggcca ctgctcctga gttctacctt ctgacttcca 42360
actatcacag aaaatggcta tctgcctggg caggagtgta catgtgaggt catctggggt 42420
ggggtggggc actcaagtcc tagccttggt gacaaatcca attagaatat gaaatcagag 42480
ctggcgggca tacagagggc tctctccctt tgatatactt taacacagca tcctagactg 42540
tggaagctgg gagggaagct aagctgttac tgatctaaca ccccacacag cttggctgag 42600
ggaaagaaca gcctccactg cggaagtgac tatttttcat tttaccaaat ctacatggtg 42660
cagaggcggg atcctaagca gtggaagccc agtgatgaag tgggattaga accttgcgtg 42720
gcatgaagct catttctgtg gcttataaaa caagtggccg gtgtcaatgg atcaatgggt 42780
gagcatgcta gaccccgaga gagacacaga tgtgatgttc acatcttcaa aatatgtagt 42840
ctgtcagagg aggaaaacac ttctattttg gaaaactttc caatcttgga atgatatatg 42900
ctagttgatt tatgggaaat tgttaatgag gaggaacaag taatccagat cttctactgg 42960
attgaacaac tcctgatttt taacccataa gttatcccca caaagtttag agtagggtca 43020
agctttctca tttggactta ctgtatatct ctggctatca gatttagtca cagacagaca 43080
gacagataga cagatagaca gagtctccag gacaactaag caattaagat gaatctacaa 43140
gaaaaacctc tgtagttaca cgggcacagg tccactgact acttatacat ctggacaatg 43200
tctaccaatt agataaagca accatagttt gccttcccca gtggtcaggg gtgggtttgg 43260
cttcagagct gggtctagtg agtagctggt gtcttctctt tggaatttgg ggacatcaca 43320
tcttgacttt tgcacttgac tccatcttga ggagaggcaa agcttcttgg gaggcttggt 43380
agaaaagctg caaattggct ctgtgctaac tcagccagca ggcaaactat aattggctta 43440
cataaagttc acgattatta ttattatttt tttttctttt ggtgacggga aacggtgaga 43500
tgcatcatca gactattcaa gggccaggac gaattgagcg acttttcctt gcgtaaacag 43560
ctctgcctat tttccagaaa gcactaatac tctgttggct tgcttccccc ctgcacaggc 43620
ctggcaaatt gcggtaatgc caggtcacca ccagcaactt cttggcaatc tcaggtgctt 43680
ctcttctgtg actagaaggg cccagattaa ctggtgggta tccggtggtc atttggagtt 43740
gagtccattt ggagcacgag atgcagatat attggatgga cagaatgaca actgaagcca 43800
ttagtaggag cagcttggcc cactgagtgt cagcaggagg ctggacttgg ttgtttctgc 43860
attagaggcc actgagttgt gttctttagg aatagaggcg agagatggtg gataaacact 43920
ggctttctcc agtgtttata tttgtcaaat acctaaaaat caacaggatc ttaaattggc 43980
ttgaaggctg ccacctggtt ggacagtgat tattaacctg gagggagact ggcagatgat 44040
cagaaatatg ggtggggcct ctgcttatgg agagaggttt tgatgaccgt gctgttgaca 44100
gaaggcagat gcgcaatcaa cattcatgaa gagtgctgaa gtcggggtcg tgtgtgtcct 44160
ggttggaggc aacatgtcta tagtgttagg aaagttgtgc tcagggggct ctcaggaagg 44220
tgtgggatgc agcaggacct cggtaagctg gcaggatgct gccccatgtc ctttgatctt 44280
ctcttcagaa tggttgcaga ctatgcatga ctcgtcgcag gtctaagaca aataaaaaga 44340
attggagaga agcacatagc caaatcagaa cacggctagt agagctatga gacaggccta 44400
tatcgtgttc cattcgctct ctgcaaccag gatcactgta gtggctctgt tgcttggcac 44460
catttgcaaa atctgcttgg agggaagagg aacacaggct taatagagtt agacaagaac 44520
atggagcttg tccatgtgcc ctggcctcaa gagagcagct gtgaaatcag cagagctcct 44580
gtgttagtgg cctttggagg aggactaagc aaatggctgc taacccttta tattgggatg 44640
ttatttaatt tatatattat aaaaatatta tgtaatatat tcattcatat actatagaaa 44700
tggttcttat tactgcattg aatatcttct gtaaagcact acagtgtaca ttttacaagt 44760
cccagacatg acagctttag tcccatttta cagaatccag aataaggttt gatagagttt 44820
ttgctcagat atctgcccat tattacgttc tggagagagg gatgaaatct agctcagcat 44880
agtttcaaac acttagctct ctctgccaag agagaatgga acaagtgaac agaatggttc 44940
acttcaactt cccatacata cgtttgttta ttctaaaggg aatggtttta cccaagaggt 45000
gaacatgccc gttttattct ctgagtttca cagtggtacc tgaatggttt gccaaaacta 45060
ctggtacttg tgagcatggt gtgtgggagc tgaaagggga gggcgtggag acattgggcg 45120
aacactttcc tatggtgtga ctctgacgag ccatggtgcc acggttgaga tggaaagaca 45180
ccccagcaaa ttgaaacttt ataaataggg aacgggcgtg ttggctctcc tgcagccctg 45240
ggtcactttg aaaaatattt gcttaatgag taacagcgag gtgtgggctc cactctgctg 45300
tgtagttagt ttctgctcct ttagtctgag cacctgagga cctgctaggg tctttgctgc 45360
tagcctgact ctttgtatag gataatagct gtaccagcaa tgactagcat ctgtccacat 45420
ttcattccgg ttctcattcc atggtttgag tggttcgtgc taggaatgta gtggataggt 45480
tgccacagtt actggagcac cctcataaac aagccgttag agaaaaaagg agagagcttc 45540
atacatgcat aggatacgtt ttgatcaaat ccacagccct tcactctctc tctccccttt 45600
caacttctcc caacagcccc ctctccccat cacctttccc tcccaatttc acgtgctctt 45660
tctctaaatc cactaagtcc gtgcacctgt aggtacgtga gtgtaggact atctactgcc 45720
gcatggatag cctgtcagga gccccatccc caaagaaaat ggagtcttcc tccccgaaca 45780
gccatcaatt cctaacggct tctcagctag gggtaagaat ttatgactcc atctcctgcc 45840
cacgcaggct tttgactggc ttggttttat acaggtcttg tgcatgcagt cccaaccatg 45900
cacacttcat gtgtgcaggg ccctggcatt tctagcaaat actgtttcac tctaatcaaa 45960
tgatcctttt ggatcttaca agttttctcc tcttctttga gatccctgag ccttgtgggg 46020
gaggggctga gatgcatcgg tctcattttg cacctaacac tccaaggtat tctaggtatt 46080
ctattctctg tccgttgacc aggcgtaggt ctctctctct ctcttttttt ttttttttga 46140
ttcccatctt ctacactgtt ggaaggggag ggagctatgc tgattaaatg agctttgaga 46200
tctgttgaaa tcccaatttg tagccttagc agacaaaagc tggaaggaaa tgatgtatta 46260
gtgccagaaa agagattgga gttctggtct cccaaaaacc tttatgacaa gaccactgtc 46320
tgatttcact gcagacatgg ctagctagct ctgctcagca aggactcaga gaggcagcgg 46380
ggtacgaacg agacaaggaa acttgcaggc aaagatgaca ggttttcaga acagtccaac 46440
ttgtatgttt gtgcttattt tggccccact tttctttcca taattatttc cctttctcct 46500
acaggggtat atttgtgttt ttcatcaact tactaaagcg taaagactat ctactaagga 46560
acaggcatgg ctagggtgtg ggtctataga agtgactaca ggttatctgt agtctcccct 46620
tggagttcgc agaaaacgtg atgtttcatg gtaatcatca taaagcagaa gggagtggat 46680
ttcagtggaa gggaccggta tgtagaatag ccccagtgta ggacagagtc tgtgtcttca 46740
tctctgacca ctatgactgg gaagaggcag tgggactgtg tgtcgtggga cccttgaaac 46800
tatgaagatt cgttcagtgc aggagaagca gggtaataac atggcttgaa acattctttt 46860
tttttaaacc ttatgtatct ccagatctca catctccaga aagttcctgg cagtcttgag 46920
acactaatat gggttctggg aaccaaatgc aggcctctgg aagaacagca agtgcttaac 46980
cactgagcat cactcccacc tgccaacatt gaaaaaagaa gttttaatta atccttagag 47040
aattccattt agtgtatttt gattccattg ctcctgaagc tcctcccaga tcctccccac 47100
cgcttaactt acccaagttt ctctccctct cgcgcctcct tgcattgagt atagtttgtg 47160
ttggctaact gcttttgggt atcaggccac aatcaataag gaaaaaacaa aacaaaacaa 47220
acaaacaaac ctgtttctca tactgaggat ggaacctagg gttttcacat attgagcaag 47280
tgctctacca ctgagctgta ctcagctctc agatcgctcc agaagcctgc tggaggatgg 47340
aagctggagg tcagctgctt tcacagggtg gagatcacag tgccggggat agtggcggtg 47400
aagatgaatt ttctagaatt tactggtggt aagatgggag ggggtcaggt ggtctcaaag 47460
gaggcggact cctaggtgcc taaattgaag tctgtgattg gaaggatggg ctgggggcgt 47520
ggcgggtaga attagaaccc taagcttctg ctgtgtagtg agttaagttt gaagtgtcgg 47580
cgatgaacat tggcttgggc cttgattttg ccattttgaa atagctgact ctctgcaggt 47640
ccgaagcgca ctgagccatc gcgactgtcg ccaggcattt gggctgccgt ccttcctccg 47700
cagcatccag cagcacagac atctgtgtgt agagcaatgc tctgttcccc cttaaggttg 47760
cttcctctga ttgcattccc caaagtggca ttgccaggtc agaggaaacg aatgagtggt 47820
ttttatggcg ttcgctgcag attgccagat tgttttttag gaagacaatc aattcagcca 47880
ccagccacct ataaatgtgc tttctagtcc atgaatctgc cgcgacggga ctttctcatt 47940
tcaaattacg tatcttcttt ttaattcagc gatgtaagga cctttggtgg tctctgtgac 48000
agtttagtca tttctagggg cataataaac ttacttgcat gatgcttgac ttttaatgac 48060
tcatggtcct tctagcgagt agaagttatg ctaatcttat ttttatcaat tctacttatc 48120
attctggtta taggttctta ctagctgtaa tggcattgct ttatattcta ttgacttttt 48180
acgatcatgt ttacgtattt gctttgtttg tgtgcacgtg ggcatctctg tgtcacagtg 48240
catggaggtc agagacaatt tatggagtct gtgggtcctg gggatagaat tctctacctg 48300
tcaggcttag tgttaagccc cattgcccac tgatccattg caccaatact gcaccactac 48360
tgtactctac tataatatca tgaaaaaaat aggattgtgt tattaaacct tttcctttct 48420
gggtctgaga atattctttt tgttttgttt tttggatttt tttttttttt tttttttttt 48480
tttttttgcc cattttgtta ggaattcatc ctttgacagg tagttataaa gaatcctaat 48540
tgctttgaat tttataatgt tattggttga cttgttgata tttctggata ttggtgtcgt 48600
atatgtggtg ggaatcccct tggtgtgttc tgaaggctat atgtgcgtgt gtgtgtgtgt 48660
gtgtgtgtgt gtgtgtgtgt gtgtgtaatg gattctgtgg gtaaacacac aggggagtgc 48720
tgggcccagc tgattcacca tttcaggctg ttcttccgtg gagtcacctg ggacaggtga 48780
tagctgatat attaattgta cccgttcagg agaagatata cggagtattt tctgaactct 48840
agactagggc atcagagact ttttctgtaa agtgctgggc agtacggtta tcttatgata 48900
tctgtggtaa ctacttaatt ccacctttgt gcaagacatg tgcagacaat gtctcgaaga 48960
gtgagtctgg ctgtgtttca ataacacttt atttgtggat aatgaaattt gagtttcaca 49020
cagttttcac tggtgctata ttgctactca ttcattcctc ctcatttccc agctgtcaga 49080
ctataaaact gttgtaggcc tgcctatagg ctatacaaaa atagacggcg atagagtcca 49140
gcctgctttt agaccagggc attaatattg tgtgagagca aattggggca actcactttg 49200
gaaaaccctt acttaatcgt gttctgggca tctaaagtga gattattaat tgtaaatcct 49260
ttctatttta ttattatttt ttgttataag ccaaggttta tttcatttta attaattaac 49320
ttactttgag gtagtgtctc tggttgacta ggctgaccca aggctaacct tgaattgcct 49380
ccgttttaag tgctgggatt atggtgtgtg ctggtctcgg aactcaccag gcaggcgctc 49440
aaatagctga gccagccaca tccccagaat cccaagtgtt tgcttgtttg tttttaatat 49500
agtgtgaaaa gtagccttgc tttctcttgt ctttatcttg acgtctgctt taaaacaaaa 49560
cttctacagt gtgctctgtg ttcggggaag tgagtttcag gattataatt ttttattttt 49620
taacagtatt attattatta ttggtatttt tgagacagag ttgctctgtg tagccctggc 49680
tgtcctggaa ctcactttgt agaccaggct ggccctaaac tcagaaatcc gcctgcctct 49740
gcctcccaag tgctgggatt aaaggcgtgc gccaccacgc ctgcataatc ttttattaaa 49800
ttaaataaaa gaaataacca atttttggtg tttgaggaag aatatcccta tggaaatcag 49860
cttgaatagg aaatcagtgt ctagcacaag ctggccttgg attttgtgat gttcccgtct 49920
ttccatccta aattctgtgg tcataagtat ggaccaccat gtaaataggc aagtaccact 49980
agtacatagg catgcatcca gatggcagtt cttttcttat ttgcttgttc tgagccagtt 50040
tgggtgtgga tccctgcctc actttgaata cactatgtat atccatctgg ccttgaactc 50100
actaagtaca ccaagctggc tttgaactca ctgcatacct caagctggcc ctgaacttgg 50160
gatattcctc atgcctttgt tcccaaagtg ctgggactac agtggatgcc actgtgatgg 50220
agttgggtta cacctttaaa caaaaaagtc tagagtttgg aggctggaaa tgtaacctgc 50280
ctagcacaca gacaaccttg gacttaattg tagcatgaca aaacaaaaca aaacaaaaca 50340
aacaacaaca aaaacaaaac aaacagcaac aacaaaaaca aaacaaaaca aacagcaaca 50400
aaacaaaaca aaaaaggaaa catttctcaa atttatactt aaaatagaat tgaaatgttt 50460
taaaacattg tctattcaca ggtaataaac ttaaagtcta gtaaaataat aaattggtgg 50520
ggtgataatt tcccaaactg gtattccatc cagcaattac catgtcagac atgttctcca 50580
tactccttct gtgtagctaa ttatcaaaac aacttagaat ggccgttgtt attgctgtgt 50640
ccattttaca agcgaggagg tagaggcttg gacgttggct ccttcccagg ttagaaagat 50700
agaaaaaaaa aatgtaattt tcttcagctt aggaaccaga ttcaccagct gacactcaca 50760
gggtgtcttc aattcacacc cgaccctatt tgcttcaaga tagctaccgg ttggaaggct 50820
agattccaca agacggactc taacggacgt caggtatcaa gagtaaaagt caggttataa 50880
cctgtgcttt ctgttgtctg actgtaagtc agagttccta tggctctcag ggggttcagt 50940
taacttgtaa gcatggcctc acatatctca gggaaacact ttctgaatat ggctctcttc 51000
tacagaaagg agacccatga taaagcatgc agaggaaggc atgcttaggg cagccatata 51060
aggagcaccg tggagctgtg gagctactgt gtctgtctgc cttggacacc gtgagctctc 51120
tgaaccttgt cctttcagag ttttatggag atgctatttc ataggcacaa tttactacgt 51180
cattagacac tggtgactaa acttaacctt caacccctct cctcatccca gagattgagg 51240
tagaactgaa agtagcaagc tgaatataaa aaccttgtgt gttctgacca ctggtctcca 51300
tcttggtggc accctctcag agcctccgtc ccctgtcatt ttatcaccac ccagaagacc 51360
ctaatcacgc tggctgtgag cttccctact ttgtaggatc catgggaaga gaccacatct 51420
atattcctta ttatcacagg atcgcggcca gcagatacct gggcgagcag ggcgtatgtg 51480
gtacattcta ggcttaaatg gtttttcctt atactttgaa gcctcagttg ctgcactggc 51540
ctgggttgta tgctcttcca gacatgccca gtcagcatga agttgcatcc ttccatcatc 51600
tactgttttc tatgacatac tatttcactt attactcact gggcatccta ttggcatctc 51660
tcagtaagca gagaataaag aaattactac tgtgttggag ggagacgggg ctgtggtcca 51720
gtgactgatt gctgtatgca ctttctcttc tgcattgcgg gttccagaga aaacagctcc 51780
taggtgaaat cttccctgtt tttttcctct ccagtgtccc ctgagcttgc ctccttctgt 51840
tcctacagtc agcacattct ggctctggca ttctctatag tcaccagctt gaaaaacagt 51900
ccctgcttcc tttgctttgg caataggaga cggctctccc tccttcccat tcctctcatc 51960
cctcccatcc tcctcttcct tcatctctcc ctctcttcca tccttccttt cttccttcct 52020
ctttccttct tttcagagaa ggcagtagaa atgaaagagc caaccaagtt tatataacat 52080
aactggaaat accctgtctg tgatttgtgg aacctttgtc cttgaaacgt ttgtttgtat 52140
gtatcccacc tgccccacaa cttcagatct ggggaattat agccatccag tgtttatatt 52200
acaaattaaa aatgatggcc cagctatctg gtcaacaatt ctgagggctg agcagctctg 52260
tctttgtcat caggtatcat atttcatagt catcctcata ggcaaacctg attaccttac 52320
aatctctaca gtaactacac acacacacac acacacacac acacacacac acacacacat 52380
atatgtatat acacacacac atacatgtgt gtgtgtgtgt gtgtgtgtat ggaaaaattc 52440
tatatcaaag tccagagcaa ttttcctgct tcttactaag gaaaagcagg tccacctctg 52500
tcttaagttt gctcgtttta taatgaaatg ttactagaac ttgagaggaa atgaaagtaa 52560
tgtctgcctg gtgcagggac gatggctcag tgggtaagat gctggcttac aaatgtgaag 52620
agatttgagt ttgaatcctt agcactcatg taaaaaggct ggatgtggtc ttgtgagcac 52680
ctgtaacccc agcattatgg aggctggaga caaggaggct tgctggagct tgctggctgc 52740
cagtcttgtt aaaatggcaa gctccaggtt tgatgagaga gccctgtctc aagtcaacga 52800
agtggagagc gatggagtag gacactctac atcctcctcc ggcttccccg tgggcatgtg 52860
cacctgtaca cacacatgca tataccacac acacacacac acacacacac acacacacac 52920
acacacacac acacgctaac gtcaatggca cagatctgtt gtaaccttta agctaccaag 52980
ggatctcttg tttatctgaa ggatgaggta atggaagtgg aattgctgaa caataagtag 53040
atgtctacat tctgacatgg attcacacat ccgggtgctt cttgtcttca gtcaggccca 53100
cctgtgctgt aaactgcaag tgacacatca taggtgtgct ataggccacc aggatgcaca 53160
gtgagactct ggaagccttc acagtcagtc acctgcacca agtgctgctc tccacttgat 53220
ctctgcttct ctcgtttaag cttctaatca ttcaataaac acttgtagtg tttttggttg 53280
ttgttgtttt taaccaaata cagtttgaga cagcatgctg atacttgatg catctatcca 53340
ctgttgtagt tgacattcct tttttttttt gattagatgt tttctttatt tagatttcaa 53400
atgctatccc taaagttccc tataccctcc ctccgccctg taggtgacat tcttagatac 53460
atggaatttt cataataatc gcagtttaaa cacagagaga atctaacctt cttatattgc 53520
ttataatctt aagcacaaag tgtaatcttc tctttttttc tttcttttaa atgagagaag 53580
aatatttgaa ctctttagta tattagcttt ttattttgag tatcacgaag aagctaattc 53640
ttagaagcca attatagttc tgttaagaga gagtaatggg gggctggaga gaaggctcag 53700
aggttaagag cacaggctgg ccaggcatgg tggcgcacgc ctttaatccc aggacttggg 53760
aggcagaggc aggtggatct ctgagttcga ggccagcctg gtctacagag tgagttccag 53820
gacagccagg gctacacaga gaaaccctgt tctgcattat agattccagg gaagacacac 53880
agagtataag tgtgtaagta agaaaacgat gacaaccata tagggaaaag aagaaaccga 53940
ggagggcttt acaattgggg atgggaggca gggagagcac ccaggaggaa gtcttgtctc 54000
tctggatgat tttgcttttt ctcagacgtc agggggaagt gagagtttga agccgagtgt 54060
gaaggaacca gattgagcgt gtgagttaga gtgggtggag agagagagag agagagagag 54120
aaagagagag agagagagag agagagagag cgagcactct gctcataaag aaacttatgg 54180
gggagaccag gaagtttcta tgagcagctg gtctctgcaa tgtttgtatt tctttagatg 54240
cccatgctgg gagctggcag atttcaccta taaagggcca agtgataaca gtaagctaac 54300
tgaggtttct gggcagaatg gtctctgtca tagctttgtc gctttcccac agtagcctga 54360
aagcagccac gagtgctagc tacatcagtg tctggactct aggaagcttg tttataagac 54420
gagctggtat gttggcattc ctttgctggc ccctggcttg aaggatggtt tgcttattat 54480
tttcctagtg ttcattaggt agttgagcaa gtgaggaagt atagtctgta cagtagtccc 54540
tggccttgag ctgcttataa gcattaagga aagataagta tatacactta cggtactgcc 54600
aaccaacatt aagagacact atgtaattag acgctggtac aatagacaga aacaggaagt 54660
gcgatgggct agttgctcat ctgcttggca tctgggtgtt tagaaagaga tttaaaggct 54720
acataaggat ggcaggattt gacagaatca caacacgcag gagggtagaa ttggttgaat 54780
attactactg agttcaacct gctcatttcc taagtgagca acccaggatc ctgttgactt 54840
cccaacaggt tgggtaagaa catgccttct cttttcaaaa tctttgtcca gttcttttcc 54900
tgactttttc tgcttgatcc acccagggat gtttatgtac gtatgtttgt gtatatgttt 54960
tatattgtta ggggtgagag aatggggtcg ctccaggtta tcgattgcat ttaggatgtc 55020
aaaagactgg gaccagggtg atcgtgtctg ctacttggac tgatgtggag agaagagaag 55080
ctaggtgagg ggtatgggag ggaagaagca gttgtgcaca atagaaaact ataccctgac 55140
ctatatacat gcaagaaagc agtcaatgaa gtcttggtgg gaagaccctc tgaagtaaga 55200
catacccatc ctgttggttg cgtgcctagc ctttaatggc taagccagct ctgtagaata 55260
tgctcattct gttgaagaac tctgaattgt tagagtgaga cagtttgtat gttaaaacag 55320
acaggtcttg gtgatgtaac agaagttagt aaaagagaaa tcacagagca acatggttgg 55380
ctttttttcc ctttgcatac acaaaaccaa ctcaaacaag agaacgggga agctgagaat 55440
ctgtagttcc aaattgctag gactattaca tagatgttta ttgagggggg gtggaagtaa 55500
aatgctaata tcaagttatt taaaaatgcc aggttaggta gagaaggggg tgactctgac 55560
tgtgagattg ggttgtatcc aaaatgtggc tcaggatcaa agaattttac agtcagaggg 55620
gtcttggttt agtgttaggg actcaagagt tagttagata ccagaaacac tcagattgat 55680
taaaaaggca agaaaaaaaa aacctcacag ccaaacaaaa taagttcctc accctgttgt 55740
atactcacaa cgatctcaga gataagacga ggtacatgaa gaaagtactt tcaaaaatca 55800
tctcagacag tattattttt tctttttcca ttttcatgtg tgtgtgtgtg tgtttgcgtg 55860
tgtctgggct ctcatgtgtg gttccatgtg cacatggagc cccaaggttg acattgggag 55920
ccattctcaa ttgctcttcc ttcctatttg gcgaggcagg tgcttaagcc aaacccagag 55980
ctcagtgata tgtgtcatct ctctagcctg tttcttctag ggatccgctg acacctctgt 56040
gatggaatta caggtagact gatgtatcca cttgatacac actcttcccg ggcaatttca 56100
gttttatact caaaagccgg aaactatgtt agatctctct gacctgtctt agccatgtct 56160
atacacatgg tgggggttgg gagaggaatc aagggtctta attggaagga cccagcctcg 56220
gttttcttga ctctcactat ccatgacctt gtctcccctt tcccatttgt ttgtcttctc 56280
ctctagggtt agctttcact ataatctttt tatattgtgc aggggccatc tttaaatatt 56340
gtcttccatt tggtctattt ctgcccagat ccatggggtt agagggaaga gctaatgtgt 56400
gaggtgcaca tatgtgcatg tgtggatgtg cgtgcgtgcg tgcgtatatg tgtgtgaact 56460
atgtatgtat gtatgtatgt atgtagaggc atgttctcag gtagctcaag tgactctcaa 56520
acttgacgtg tagccaaaga tagccttgaa ctcctgatcc tcctacctca gcttctcaag 56580
tgttgggttt acaaacttgc gccatcacaa ggggatattg ttttgttttg ggacaaagtt 56640
tctttatgta gctcagactg gtctggatcc tgtgatcctc ttgtctgagt ctccctagta 56700
ccggcaagta cttccacaac ttggaagggg aaactcttgt ttagatacag tttttccttc 56760
ttcttcttta aatagcacag tgggattagc tattgactct ggaattggga gagactttag 56820
aggaccctgt agtcttgttt gagtaataag ctctgctctc aacaggcctt ccctctgatt 56880
aggctttgca aagcagagct gctctgtttg agacagaagt gagggggctt ggagcctacc 56940
tcccattgct ccttggcaag aggcagccct gtgatttttg tccagttcag cgcttgcttc 57000
ttgtcccact ggtttcttcc tccatccact tcgctaaaca cagttaattc acactctcct 57060
ttattctgtt tgcaggagat agatgaggta attttatagg tcagcattat agtcccttaa 57120
aaactgataa aggagccagg catggttgtg caaactagcc cagctccgtg gctcatacct 57180
gtaatcccag cagcaactgg agagtctgag tcaggatttc cacgaggcca gcctgggtta 57240
taaaataaga ctctatctca aaacaaaata tcttcaaaat aattttaccc ccacgaaatc 57300
aagaatccca aatggagcaa gcatggtata gagtgtaggg aatgtgcagt tgctgggtgg 57360
ggtttgaaca cagctaagtg accccaacaa gtcagacatc aggaaagaac ctaccatccc 57420
tgtcttagaa caaaagtctg gacccttgtc tagtctggtg ggtgttgtca gcaatgtgca 57480
cactcagggt ggctccctgg atcaggagcc ctgggtgggg aaggctgggg ttgaggctcc 57540
atttcctaga gctttgtgta tctccccagg gtgcacactt ttgagtctac agtgggggtg 57600
gggcactaat cttgtactcg ggctccattg gacagatggt ttcctccacc ctgggcatct 57660
gctgaactcc ggatagggtg tctgggctgg ttgtgcaagt agagggagca ggaaaaggaa 57720
gggccaagcc aaacgctgag agaggagact taccaccaag tagcaggatc ttctctttct 57780
caatttccaa tatgaaatta aatttcccaa caagaaaacc aaccactatc catcgccaac 57840
cacctctgcc cctactttca gactcagaag gaagaaaact aagtatatcg taaactctaa 57900
ggaggaaacc tcaagaaccg gtgagaggcg gggaagtacc ctggccccac ataactgtgg 57960
ggttgggaaa agaatagact ggggtcaagt ttcgagatgc taagaagaca gactcttgat 58020
caccttgcaa gcagtttttt ttctttttct tttgctttgt tctttcagtt accgatgtag 58080
ctgtaaatct gtaaatctag aaggaatttg ttcggtagct ggtagcttgg ggcagccatg 58140
attttcatac aaatttctcc atctcactga ggatggcaaa gactatcagg gccttcattt 58200
tgacagcccc agggaagcag tcactctagt cttttgctcc ctgcttctct ttcacagcat 58260
ctcaggactt ggaacttggg atacccccag gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 58320
gtgtgtgtgt gtgtgtgtgt gtggtttgtc cagacagggt gtctccatgt agccctggct 58380
atcttagaac tcaattggta gaccagacta gctccaaact cagagatccg cctgcttctg 58440
cctcccaagt gctgggatta aaggcatatg ctaccacacc caacgggtcc tccaagtttt 58500
taatctggaa gttggtgaaa ctctgacctg ctgggtgaag tttttatttt agaacatgaa 58560
cactgagtta ttcttgctgg acccaagctc aatgggtaga tttctcaatg gatgcctgca 58620
gggattgtgt ctatcggttg tggccttcag agactggaca aactgcgttt gaatctaaaa 58680
gcaccagctc cattgtttaa tgcacataac aggactgtca aaagtatggc tgtttgttaa 58740
aacaaaacaa aacaaaacaa aacaaaacaa aagtttatca tcaggtatgc aggtgctata 58800
gaaatgacaa ctttggcaca cacctccctc tttctgatgt caagttggtg tggtacccgc 58860
cagatcttga acagtggtga tgacctgtta ttgctgttgc tgttgctgtt gctctgttcg 58920
cctctgctcc tctatctgac acctctctta tttctttcag cttggattcc tcagcaccat 58980
cacagcttgg tacattctgg tgccaagtgt ggccattccc ctggctatcg ccttcctctt 59040
cttcttcatc tgtgtgtgcc gcaataacca gaagtcttca tcaggtaccg atttaaatga 59100
tccagtggtc ctgcagagga gagattggga gaatcccggt gtgacacagc tgaacagact 59160
agccgcccac cctccctttg cttcttggag aaacagtgag gaagctagga cagacagacc 59220
aagccagcaa ctcagatctt tgaacgggga gtggagattt gcctggtttc cggcaccaga 59280
agcggtgccg gaaagctggc tggagtgcga tcttcctgag gccgatactg tcgtcgtccc 59340
ctcaaactgg cagatgcacg gttacgatgc gcccatctac accaacgtga cctatcccat 59400
tacggtcaat ccgccgtttg ttcccacgga gaatccgacg ggttgttact cgctcacatt 59460
taatgttgat gaaagctggc tacaggaagg ccagacgcga attatttttg atggcgttaa 59520
ctcggcgttt catctgtggt gcaacgggcg ctgggtcggt tacggccagg acagtcgttt 59580
gccgtctgaa tttgacctga gcgcattttt acgcgccgga gaaaaccgcc tcgcggtgat 59640
ggtgctgcgc tggagtgacg gcagttatct ggaagatcag gatatgtggc ggatgagcgg 59700
cattttccgt gacgtctcgt tgctgcataa accgactaca caaatcagcg atttccatgt 59760
tgccactcgc tttaatgatg atttcagccg cgctgtactg gaggctgaag ttcagatgtg 59820
cggcgagttg cgtgactacc tacgggtaac agtttcttta tggcagggtg aaacgcaggt 59880
cgccagcggc accgcgcctt tcggcggtga aattatcgat gagcgtggtg gttatgccga 59940
tcgcgtcaca ctacgtctga acgtcgaaaa cccgaaactg tggagcgccg aaatcccgaa 60000
tctctatcgt gcggtggttg aactgcacac cgccgacggc acgctgattg aagcagaagc 60060
ctgcgatgtc ggtttccgcg aggtgcggat tgaaaatggt ctgctgctgc tgaacggcaa 60120
gccgttgctg attcgaggcg ttaaccgtca cgagcatcat cctctgcatg gtcaggtcat 60180
ggatgagcag acgatggtgc aggatatcct gctgatgaag cagaacaact ttaacgccgt 60240
gcgctgttcg cattatccga accatccgct gtggtacacg ctgtgcgacc gctacggcct 60300
gtatgtggtg gatgaagcca atattgaaac ccacggcatg gtgccaatga atcgtctgac 60360
cgatgatccg cgctggctac cggcgatgag cgaacgcgta acgcgaatgg tgcagcgcga 60420
tcgtaatcac ccgagtgtga tcatctggtc gctggggaat gaatcaggcc acggcgctaa 60480
tcacgacgcg ctgtatcgct ggatcaaatc tgtcgatcct tcccgcccgg tgcagtatga 60540
aggcggcgga gccgacacca cggccaccga tattatttgc ccgatgtacg cgcgcgtgga 60600
tgaagaccag cccttcccgg ctgtgccgaa atggtccatc aaaaaatggc tttcgctacc 60660
tggagagacg cgcccgctga tcctttgcga atacgcccac gcgatgggta acagtcttgg 60720
cggtttcgct aaatactggc aggcgtttcg tcagtatccc cgtttacagg gcggcttcgt 60780
ctgggactgg gtggatcagt cgctgattaa atatgatgaa aacggcaacc cgtggtcggc 60840
ttacggcggt gattttggcg atacgccgaa cgatcgccag ttctgtatga acggtctggt 60900
ctttgccgac cgcacgccgc atccagcgct gacggaagca aaacaccagc agcagttttt 60960
ccagttccgt ttatccgggc aaaccatcga agtgaccagc gaatacctgt tccgtcatag 61020
cgataacgag ctcctgcact ggatggtggc gctggatggt aagccgctgg caagcggtga 61080
agtgcctctg gatgtcgctc cacaaggtaa acagttgatt gaactgcctg aactaccgca 61140
gccggagagc gccgggcaac tctggctcac agtacgcgta gtgcaaccga acgcgaccgc 61200
atggtcagaa gccgggcaca tcagcgcctg gcagcagtgg cgtctggcgg aaaacctcag 61260
tgtgacgctc cccgccgcgt cccacgccat cccgcatctg accaccagcg aaatggattt 61320
ttgcatcgag ctgggtaata agcgttggca atttaaccgc cagtcaggct ttctttcaca 61380
gatgtggatt ggcgataaaa aacaactgct gacgccgctg cgcgatcagt tcacccgtgc 61440
accgctggat aacgacattg gcgtaagtga agcgacccgc attgacccta acgcctgggt 61500
cgaacgctgg aaggcggcgg gccattacca ggccgaagca gcgttgttgc agtgcacggc 61560
agatacactt gctgatgcgg tgctgattac gaccgctcac gcgtggcagc atcaggggaa 61620
aaccttattt atcagccgga aaacctaccg gattgatggt agtggtcaaa tggcgattac 61680
cgttgatgtt gaagtggcga gcgatacacc gcatccggcg cggattggcc tgaactgcca 61740
gctggcgcag gtagcagagc gggtaaactg gctcggatta gggccgcaag aaaactatcc 61800
cgaccgcctt actgccgcct gttttgaccg ctgggatctg ccattgtcag acatgtatac 61860
cccgtacgtc ttcccgagcg aaaacggtct gcgctgcggg acgcgcgaat tgaattatgg 61920
cccacaccag tggcgcggcg acttccagtt caacatcagc cgctacagtc aacagcaact 61980
gatggaaacc agccatcgcc atctgctgca cgcggaagaa ggcacatggc tgaatatcga 62040
cggtttccat atggggattg gtggcgacga ctcctggagc ccgtcagtat cggcggaatt 62100
ccagctgagc gccggtcgct accattacca gttggtctgg tgtcaaaaat aataataacc 62160
gggcaggggg gatctaagct ctagataagt aatgatcata atcagccata tcacatctgt 62220
agaggtttta cttgctttaa aaaacctccc acacctcccc ctgaacctga aacataaaat 62280
gaatgcaatt gttgttgtta acttgtttat tgcagcttat aatggttaca aataaagcaa 62340
tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc 62400
caaactcatc aatgtatctt atcatgtctg gatcccccgg ctagagttta aacactagaa 62460
ctagtggatc ccccgggctc gataactata acggtcctaa ggtagcgaat aacttcgtat 62520
aatgtatgct atacgaagtt atatgcatgg cctccgcgcc gggttttggc gcctcccgcg 62580
ggcgcccccc tcctcacggc gagcgctgcc acgtcagacg aagggcgcag cgagcgtcct 62640
gatccttccg cccggacgct caggacagcg gcccgctgct cataagactc ggccttagaa 62700
ccccagtatc agcagaagga cattttagga cgggacttgg gtgactctag ggcactggtt 62760
ttctttccag agagcggaac aggcgaggaa aagtagtccc ttctcggcga ttctgcggag 62820
ggatctccgt ggggcggtga acgccgatga ttatataagg acgcgccggg tgtggcacag 62880
ctagttccgt cgcagccggg atttgggtcg cggttcttgt ttgtggatcg ctgtgatcgt 62940
cacttggtga gtagcgggct gctgggctgg ccggggcttt cgtggccgcc gggccgctcg 63000
gtgggacgga agcgtgtgga gagaccgcca agggctgtag tctgggtccg cgagcaaggt 63060
tgccctgaac tgggggttgg ggggagcgca gcaaaatggc ggctgttccc gagtcttgaa 63120
tggaagacgc ttgtgaggcg ggctgtgagg tcgttgaaac aaggtggggg gcatggtggg 63180
cggcaagaac ccaaggtctt gaggccttcg ctaatgcggg aaagctctta ttcgggtgag 63240
atgggctggg gcaccatctg gggaccctga cgtgaagttt gtcactgact ggagaactcg 63300
gtttgtcgtc tgttgcgggg gcggcagtta tggcggtgcc gttgggcagt gcacccgtac 63360
ctttgggagc gcgcgccctc gtcgtgtcgt gacgtcaccc gttctgttgg cttataatgc 63420
agggtggggc cacctgccgg taggtgtgcg gtaggctttt ctccgtcgca ggacgcaggg 63480
ttcgggccta gggtaggctc tcctgaatcg acaggcgccg gacctctggt gaggggaggg 63540
ataagtgagg cgtcagtttc tttggtcggt tttatgtacc tatcttctta agtagctgaa 63600
gctccggttt tgaactatgc gctcggggtt ggcgagtgtg ttttgtgaag ttttttaggc 63660
accttttgaa atgtaatcat ttgggtcaat atgtaatttt cagtgttaga ctagtaaatt 63720
gtccgctaaa ttctggccgt ttttggcttt tttgttagac gtgttgacaa ttaatcatcg 63780
gcatagtata tcggcatagt ataatacgac aaggtgagga actaaaccat gggatcggcc 63840
attgaacaag atggattgca cgcaggttct ccggccgctt gggtggagag gctattcggc 63900
tatgactggg cacaacagac aatcggctgc tctgatgccg ccgtgttccg gctgtcagcg 63960
caggggcgcc cggttctttt tgtcaagacc gacctgtccg gtgccctgaa tgaactgcag 64020
gacgaggcag cgcggctatc gtggctggcc acgacgggcg ttccttgcgc agctgtgctc 64080
gacgttgtca ctgaagcggg aagggactgg ctgctattgg gcgaagtgcc ggggcaggat 64140
ctcctgtcat ctcaccttgc tcctgccgag aaagtatcca tcatggctga tgcaatgcgg 64200
cggctgcata cgcttgatcc ggctacctgc ccattcgacc accaagcgaa acatcgcatc 64260
gagcgagcac gtactcggat ggaagccggt cttgtcgatc aggatgatct ggacgaagag 64320
catcaggggc tcgcgccagc cgaactgttc gccaggctca aggcgcgcat gcccgacggc 64380
gatgatctcg tcgtgaccca tggcgatgcc tgcttgccga atatcatggt ggaaaatggc 64440
cgcttttctg gattcatcga ctgtggccgg ctgggtgtgg cggaccgcta tcaggacata 64500
gcgttggcta cccgtgatat tgctgaagag cttggcggcg aatgggctga ccgcttcctc 64560
gtgctttacg gtatcgccgc tcccgattcg cagcgcatcg ccttctatcg ccttcttgac 64620
gagttcttct gaggggatcc gctgtaagtc tgcagaaatt gatgatctat taaacaataa 64680
agatgtccac taaaatggaa gtttttcctg tcatactttg ttaagaaggg tgagaacaga 64740
gtacctacat tttgaatgga aggattggag ctacgggggt gggggtgggg tgggattaga 64800
taaatgcctg ctctttactg aaggctcttt actattgctt tatgataatg tttcatagtt 64860
ggatatcata atttaaacaa gcaaaaccaa attaagggcc agctcattcc tcccactcat 64920
gatctataga tctatagatc tctcgtggga tcattgtttt tctcttgatt cccactttgt 64980
ggttctaagt actgtggttt ccaaatgtgt cagtttcata gcctgaagaa cgagatcagc 65040
agcctctgtt ccacatacac ttcattctca gtattgtttt gccaagttct aattccatca 65100
gacctcgacc tgcagcccct agataacttc gtataatgta tgctatacga agttatgcta 65160
gccacagggg cactgcattc tgggaatcaa cctactggcg gggtgatttc atttcgtttc 65220
tgacttttgt gttttggtgt gtatgtatgt gtttaacaga gtgtatggcc ggtgagtttg 65280
ggttctttct ttctttcttt ctttctttct ttctttcttt ctttctttct ttctttcttt 65340
ctttctttct tccttcctga aagtgaatgt ataaagcctt tacaatgtat aactgttgga 65400
aaatgcccac cactaaattt ttttttaagt tccacatatt ctccattttt gccttcttat 65460
atatatcttc aacactattc tgtgcacttt aaaaacttaa cataaacgca gtgtgacttc 65520
tcccatatgc tgggtcccga gactctcaac ttcttaaaaa cctaatggca tcttgtgact 65580
cctagaagta gacataagtc tttcaacctt cacacctact ctttctgttt taattattat 65640
tgctatttgt cttattgttt gtgctttaca agcgttcttg aggacggagg gaatctacga 65700
ccctgttgat gactgtaact ctattcgact ttgagttgtc ttcttcatgt cttgttatat 65760
agttcatatt catggctgaa acttgaccat actccctagc gctgattgta tggttttcgt 65820
ctggacaccg tacactgcct gataacttgt gcacctctta acgctactat gctctgggct 65880
ggagaatgaa atctttaagt caccaggact tgctgtttca gtggcttgac acctgggcca 65940
ccaaagaact cgatcttcat cttttaggga cacctctgct gcaccttgga aagccaacct 66000
taagtgccag tggcacttta tgcccagctt tgctttgaaa gatatctttc ttgttttttt 66060
tatccttctc tttctctctt ttttttaaaa atacacatag tcaataggtc cagtctgccc 66120
tcaaggcctt gctgggtttt cttcatcatc caatcacttt cattaaaaat ggctgcagct 66180
gtaagaactc ttgtctgata aattttcaac tatgctctca tttatctacc tgccctctga 66240
tgctcagtcg tcagactcta atgcaaaggt ggacgtcggc tgcctttgcg tgggcgggct 66300
tagtggtgag gaactgatat cagaaaaaaa atgccttcaa gtatactaat ttattaataa 66360
atattaggtg tttgttactt gtgtggtttt ggtatattta ctactgaact ttcgcctttc 66420
cctctgctca ggttctagcc ctgttcatct cttggggaag gatgtgtgtt ctgaaaccct 66480
tctcctgtcc aatctgtaaa tcatgaatat tattagcaaa agtccctttt ggagaggtac 66540
ttggaggttc actgcacagg gctctgataa gcactgccaa gcctttccta gtctttcgga 66600
gttaaacctt aggtaacttg atacctgtag gacgatctgc acacattcac aggcttctag 66660
ccaaaacctc actgtccctg acgaactcca gagggcttgg tcagcagtga ggcggatgtg 66720
gtcctgtgtt ggtgggatat ctcaagctca ctgcaggttt tcctaagctt ggaccccacc 66780
tctgcggaat tccaatgatc aaacgctagc aactttaaca tcctcttttt gtgagaacct 66840
ggaagctgat actgtgtata ctgtgacccc ccacgtcaac aactgggact gtcttccggt 66900
ttcactcatc tctgtgtggc agctttcaag atgaacatcc ttgtttccct tccctcttgt 66960
tggtgcatgc ctttagtcca ttggaagaga gaggcaggag gatctttgat tttgaagcta 67020
gcctgggagt ttcaggacag cctggctacg ctaactaaaa aaaaaaaaaa aaaaaaaaaa 67080
aaagatcaca catgcgcaca cacgaacaca cacatacaga gcaacaagaa caaacaagaa 67140
tgggtcagtt atgatggggg aggaaacagg ttttgtcagg ttctcactgt gtcagaagat 67200
ttagaactga gacatacaat ccattcatta attactagta tgttaagttt atagtttatt 67260
agtaatttgg gaatttttta ttaataaccc aaatttgtgg ttttatattt tacaacatat 67320
aaagtttaat tactttattg gatctttaaa tttgtcttaa cgggttccta ttattatgcc 67380
cattttacag atgaaattgg gcttgtaaag ctaagtatat gagatggttt cttatcacta 67440
gaacagagtc cctgaaaagg aagaaaagaa attctttaag ggaggaaacg ttgatcttaa 67500
ctcatggttt ccaaggcttt aagtccatgg ttggctggct ctgttgcctt tggttgatgg 67560
taaagcagaa acctggtaag aaaacacgac ggtggaaggt tgcttacctc ctttcggcca 67620
gcaagcagag agacacagga agagtcttgg gacaggataa ctcttcagtg gcacaggtcc 67680
agtgaccttc tactagctag aaccccctcc ctaccttata gtctattcag ctatgaacac 67740
atccatggtc gaatatacca ctagctgaag cccaaacctc caatagatga gcctttgtgg 67800
gggacactta atatccgaag cataaaacca aggaatgtgt ttaagccctc actgagaagg 67860
ttagcaaggc taggtttgaa tccgtgttgt gtatgttttg ggaagaaggg tagagcgagt 67920
ggctgtaatc taagactgtt cattctcttt ataagatcac tgaccagaaa cctgttgcca 67980
cctgaaacag tgggcagaaa catggcagtg aaatctgtct gggtcatgag taaagttcaa 68040
atgcaagtta agtaagtggt acaaacgtag gcatgagaac taaacattag cattatatgg 68100
tgatcccatg atgcatagct ttcccagaag gcaatgcacc atcagctact ttcttaaagt 68160
acccagagtc aagtgtgatg gatggcacac acctggaacc cagcactcac ttgcaggctg 68220
gaagaccaag gccttagggt cagcctgggg agagggctca gtcagtaaac catttgccac 68280
acaagcctga gaacctttgg atacctggca cagcaaagta cagggctctg tggtgcacac 68340
ctacagtctc cgtgttgggc agacagagac aggaagatcc ctggggcttg ctggctggcc 68400
agtctagctg aactggcaag caccaggctc aggcaagtca ctccatctca aaaaaataag 68460
gtgtaaaatg gtggaagaag gcatccaatg tccaactgca gcctctgcat atgtatgcac 68520
aaggtcatac acacacaaac acagaggagg aggaggacga ggaggaagag aaggaagagg 68580
agggattcaa cgttagcctg ggctacatag taagaccctg tctcaaaaca gccatatagc 68640
tattggagtt atagttcatt gacatttgat caacaacact gcagaaactg ggtgtgacat 68700
tgcatatctc ccaattcttt cactccagag gtgaaggcag gaaagataaa aagttcaaaa 68760
tcatctttgg gtgtatagca agttggagac cagcctggga cacattagat gctgtaaaaa 68820
aaaacaaacc aaacaactga aataaaacaa aaattcagca taaaatacta aaatatgtga 68880
ctttctgatt aaagctaatg atagcaccat ttgtaccata gaaaggtctt ctctggcttg 68940
cgcttcttcc tctgaggagt atagacagct gaaaaggaag gctgctagtg tgagggcaga 69000
ggagacaaga gagcaaccag aagaataaga aacagaagca actgttggga gatccaagcc 69060
atgttatgca ggcaggcagg agaaggagtc tgttcaccaa tttgaaggac taagaaggag 69120
tttgtgaccc ctgggaaaag actacagact cgatccaatt ataatgaaaa gatttgttga 69180
ttagctgcta gctggatgag taatctctga gccaacttcg agattacttc gcagaagggt 69240
tacggggaag gactttaaaa ggagaatatc acacaaagac cttcaatatc taggcaagca 69300
agtaacaact gttctatttt gacaaattaa gtgattgagg cgactcaaaa caatcttggg 69360
ttatctgtgc aacaagttac agaggcaaaa aaaaaaagtt agtcataaca agtgttatgt 69420
atggggagga aggtgtgact gagtcagggt tattggaaat ttatcttccg gggaatggag 69480
ttagagacta gtgggtatgg aaatgaatgc ctagcataaa acggagcttc tttcattttc 69540
ttcagagagt aatatagttc ctgtgggctg ttttaggctg aactcaatta gatagggctg 69600
cttttcaagg agaaactgct tcaaggagag gaaggagctg ggcgagcatc tgtggttctc 69660
caactttcat gtaaataagt cacccgggag tgagcagctt gttctcttta aaaaaggctg 69720
attcccacaa tctgattgga gaggtttgtg gtgaaattca aaaatgaagc ccttgcaggt 69780
ttttggacca cacttagaaa actatcttta gagaatttcc gttcctgcca atggggacaa 69840
gaacagctaa gaggagctgg ttagactcgc accttcagag gcctcctgtc taccctttta 69900
atgtgcaaat gagatacctg aaggtcctgc tcacaggcag actctccagg cctcttctgg 69960
gaaagggcag ctggcatcct gtgttgctgc caagctcttg ggtaatacag gcactgctgg 70020
gtttttcttt ttccccgtga aactgggtag tctgggatga ctttaccttt caggaaaggg 70080
gcagaacaaa cacaggagtc gatcactcat ttcacaggag ggaaggaaac acactttgat 70140
gagctgaaga aacacccaga accaagcaaa tctggtcaaa acttacaact ggttggggct 70200
gggcttggta aaagtgcctg cagcagaagc acggggacag gagttcggat cctcagcatc 70260
catgttagaa aataaggtag gtgcagtgct gcatgcccca tgcatgctcc cagtgctggg 70320
gaggcaggga cagcagaatc ccaggggttt gttggcttgc tagctccagg gtccatgaga 70380
gtctgtgcct aaatgataat aaggtagaaa ggtgatcaag aaagacatag aactttgggc 70440
acacaaagcc tacccctcct ccagcaggat tgtataacag cagcagaaag aaaggagact 70500
tacagaaaga aaggagactc ctcgaagccc aactatttgg catttgtgca gagagctcta 70560
gggatgtagc tttcaagggt ggacttcttc acgagcagtt gtatttgggt tactcatact 70620
tctgtaagta actgcaagaa attcatctgg acgcaagaag catcatttct ttgttccgtt 70680
ggcagtgccc tatctgaggc aaatagacat ttgctgtgtc tctccaggaa aagtcacaca 70740
atacacagtg aggctgcctg gcagaggaat cctgtttatc ttgtggtcaa ccagaataaa 70800
agagacaaga aaggccagag tctcagtata ccctagaaga atatttcccc aggtaatcaa 70860
cttccctcca ttaggctgca cctcttaaag tgtctgctac ttctaaatag taaactggtc 70920
acaaagatta gacacatgtc ctttgggact cacttctgaa ctgtacccct gggctatgaa 70980
ttggtcactt tcctgctgtt atgacaaaat atcaccactc aagacaatct aaggaaaaag 71040
aatttgagct tccacttttg gtgagagagt ccataaagac agggaagaga tggcagctgg 71100
aacaggaagc taagcctcaa tcaagaagct gagaaagtga gctgggagta gtgaggctat 71160
ataacatttc aaagtgatct gcctcctcca gcaaggttgt acctcctcat caaacagtac 71220
tacctacttg gtcccatctt ggttgctttt ctactgctgt gaagatcatg accaaggcag 71280
cttataaaaa aggaagcatt taattgatca atttataaac actttatagg ggactggaaa 71340
ggtggcttag tggttaagag tactggctgt tcctcttcta gaggttctga gttcaattcc 71400
cagcacccca tggcagctca caaccatgta taatgggatc tgataacttc ttttggcctg 71460
aaggcattca tgaagacaga gccctcatat acattaaata aattttatga acagcttata 71520
aaaacgttat aaaacataat ttcagagtta ccctatgact actatggcag gaagcatggt 71580
ggtggcaggc aggcatagcc atggagcagt agctgagtgc ttacatcatg cctgaaagat 71640
gttgacagag tgagacaggg cttttaaaaa caaaaaccac gttccctgtt atgcacctcc 71700
tacaacaggg ccacacctcc taatccttcc ccaaacagtt ccaccaatta gagatcaaga 71760
attcaaacat gcaaatcatg ctcattcaaa ccaccacaga gcctacaagg ctctcattca 71820
aagcaccaca agacagcaag acctatatga atcagacctg aggtgatggc tgtagcttcc 71880
tgagaaaggg tttggggaat ctttccaagg agccagcttt gctctgtccc ttacaagtag 71940
ctgtctcccc agctctctag gatcttccta gagattagat taggatttct cccaaacaaa 72000
cacaaaaaaa gtccaaatgg agagggttca aactcaacat ttaaaaaaag tgagtcacag 72060
taattatgtt ggggctcaaa tatctatttc ttaggataga aatctctcat atttaaggtc 72120
tttgggagga gaaacatgaa aaatttctgg agttgtcatg catacacaca tacacataca 72180
cactatatat atatatgtgt gtgtgtgtat acacatatat acacacacat atatgtatat 72240
acacacatat gtctatatgt atatatacat acatatatac acacacatat atgtatatac 72300
acacatatgt ctatatgtat atatacatac atatatacac acacatatat gtatatacac 72360
acatatctat atgtatatat acatatatac acatataata tttaaatatg ttttatatat 72420
ttatatatta tacataaata tgcttaagta ttatctattt aaatatatat ttaatattta 72480
aaacatatat tataccacac gcagtcctct aaccctccat tggagatgtg cctgttccgt 72540
gttagttagc attctcctac tcagtcaccc tctgcttcat ccactgcata atgtcaaatg 72600
ggagatctca cagagaaaga acatgggaca gcaagttcat tttcaagatc acatgacagt 72660
tatttccata agtatagaca cgtggatttc acatctcgtt tcgtccattt gtttgaatgc 72720
agcatacctg taggacggtg aaaggcagcc tggttcctgg ttgagctaag gctagaaacc 72780
ctactgaccc taaagggatg cttggagttt gcctggttct taggtaccag gcttcatgca 72840
cgaggccaca gccctccata gatttgtggc cgtcagtaac gtaagggcaa caccgcaagc 72900
caaagccccc ccccccacct gccacacaca cacaggtaga ggacgtgacc catggtcacc 72960
tagcctcaag acacatctct attttaatga ggtacctaaa ggcctggagg acttagccaa 73020
taaactctcc ttcccagatg ttccttcctg caaaaaaggt atttaacttc aggccctccc 73080
tgagaagtgg ggtacggttt tactcagcca cctttcacca ttacaataaa tgccttaaaa 73140
tcatggattg ctacttttca ccgggatctg ctatggagaa gaccttcttt gcctacagag 73200
ctaccatcta atttcttgta gaagacctct ctgctctccc agccatggct gccaccaagc 73260
tcaagcttgc tgccacagac agccagagct cctctttttt ccccctcagc cctgggctag 73320
attcagcccg ctggccccca ctctgttctc aggtcttttg tggctctcag tatgcctggg 73380
tgtccaagag cccgagaacc agacagctag ggcctccttg taggccgggg gacccccaag 73440
ccagttctgg ctgtcctggg atctcagact gtgctttccc attctggaag ggttattcca 73500
tggctcccca tagaccaaca ccagcccggt gacagtgtgg ggtaagctct gtcaaaactc 73560
cagcgttctg tctccccaag tagctgtgct ctgtggtggg cacccctaca cacacccatc 73620
cacagaaaca cagatgagtt cttccactta gtctgagaca tctgaacagc tactaggttc 73680
tgggctaggg gctagacgtg gggagaattt gatggagcgt tgaaactgct gatgaggaaa 73740
gagaagctct ctgttcacgg ctctgtcctg gacatccaga gcaaagtata gaaatgtact 73800
tatgctatag gctgaataac tgagtgaatg caagctcctg actgcaagaa gttcccaaca 73860
tagcaagaga cacgaagaga gacattctta taacaatggt aagtgatgag aaatatggaa 73920
acagtaatta attatatcca agcataatgg ttacattcca tagaagcatt tgaagaccca 73980
gacaccaaat acaactcaaa gaaaagtgat ataaaatttt ctagtgtaag cctagtaatt 74040
tcaatgataa gttgcatcaa aagtcaggaa ctgatcaatg cgattctatc ctcttcagag 74100
ctttgaccac gataagaaat agcttgatgc cagcttaaca ttagactcta aagcagtgac 74160
cttcctagtg ctgtgaccct ttaaaacagt tcctcgtgtt aggctgaccc ccagccataa 74220
aattacttcg ctgctaattc ataactgtag ttttgctact gttataaatc ataaggtaaa 74280
tattgatatg caaccctcca gaggggtcgt gacccccacg ggttgagaac cagtgctcta 74340
aagtgaactg caggtgtgct gtgggctcta ccacataaac aaggatgcca tagcttttct 74400
actgttgttg ttccccgttt ccaggcttat cattaaccat catcaggaga tacgaggccc 74460
aggcatgtga cagcttagca gaagacaggc caagtgcaac cttgtgtgga gctcattctc 74520
tgagcaaatg ttcaaaggct ctgggggtgc tcattgctca gtctcacttt gaagcctgta 74580
ctataggaac aggcattatt tccactctgt tgataaggaa tctgagacat gcattgtgat 74640
ggccccagta ttatacagct agcaaagggt ggagggagcc aggaaggaca tttgtagagc 74700
tgagtgactc aaggtcataa aatggcaagt ggcaagtggc aagtgaggtg acttgactca 74760
tacctgcctg gaaccttttg tcttgactca accaaactcc tccttattga ttttttaaaa 74820
aaggtatctt tttaaaaaat gtatgtgcat gttgcactgg ctggttctgt gtggcttgag 74880
ttatcataga gaaagatgcc tcccttgaag aaatgcctcc atgagatcca gctgtaaggc 74940
attttctcaa ttagtgatta agggtgggag ggcccactgt gggtggtgcc atccctgggc 75000
tggtagtcct ggattctatt agaaagaaag gcaggggagc aagccagtaa gcagcaccct 75060
tccatggcat cagctcctgc ttcctgacct gcttgagttc cagtcctgac ttcttttgct 75120
gatgaacagt aatgtggaca tggaagctga ataaaccctt tcctccccaa cttgcttgtt 75180
ggtcctgatg tttgtgcagg aatagaaacc ctgactaaga caaacgtgtc tgtacccgca 75240
tgtgtttatg cttaccatgt gcttgcagga gcccatagag aacagaagag agcttctcaa 75300
gcgatcctcg gaaactatga gctgtctgtg ggtgctgaaa actgaacccc catcttccat 75360
aagagcaata agcattctta actaccagac aatgcctcca gccctttctt tttttttttt 75420
attacgtatt ttcctcaatt acatttccaa tgctatccca aaagtccccc attcccctac 75480
ccacccattt ccactttttg gccctggcgt tcccctgtac tggggcatat aaagtttgcg 75540
tgtccaatgg gcctctcttt ccagtgatgg ccgactagga catcttttga tacatatgca 75600
gctagagtca agaactccgg ggtactggtt agtccataat gttgttgcac ctacagggtt 75660
gcagatctct ttagctcctt ggatactttc tctagctcct ccattggggg ccctgtgatc 75720
catccaatag ctgactgtga gcatccactt atgtgtttgc taggccccgg catagtctca 75780
caagagacag ctataacagg gtcctttccg caaacgcttg ctagtgtatg caatggtgtc 75840
atcgtttgga ggctaattat gggatggatc cctggatatg gcagtctcta gatggccgat 75900
ccttttgtct tagctccaaa ctttgtctct gtaactcctt ccatgggtga ttgtttccaa 75960
ttctaagaag ggacaaagtg tccacacttt ggtctttgtt cttcttcagt ttcatgtgtt 76020
ttgcaaattg tatcttatat ctcaggtata ctaagtttct gggctaatat ccacttatca 76080
gtgagtacat atcatttgag ttcttttgtg attgtgttac ctcactcagg atgatgccct 76140
ccaggtccaa ccatttgcct aggaatttca taaattcatt ccttttaata gctgagtagt 76200
actccattgt gtaaatgtac cacatttttt gtatccattc ctctgttgag ggacatctgg 76260
gttctttcca gcctccagcc ctttcttaat cactggacta tctctccaat ccttccttat 76320
tgacatatgt ttaaaatgta aagtattttt gttatgtgtg tatgcaaatg aatgtgctac 76380
aaaaaggatg tggacaacat tgaagaattg gttctttacc cacccaagga tcaatcccag 76440
gctgtcattg actgggcttg ctggccactt agtaaaaaaa aatattacat ttggtaggaa 76500
ggctggctat cctcggtcta atgaacttcc tgacccaacc atcccagtga tatattatag 76560
acatacatca ccatgtctga cattgatagt tggattattt tttttaattt tgaaataagt 76620
tataacacat taagtttaac aatactataa cgttcacatt ttcttttcca ccagtttccc 76680
ccaagtaagt tagccttaga cataatcaaa accaggagat tgacattatt atattaccaa 76740
gcaaagacgg atgctaggtg gttcacgctg gtttcttgca cacacttttc tgatgtattt 76800
taaacatcag atgtactgat tcctgtaccc accactacca tctggaaata gcactacgaa 76860
atgtccctaa ggacactctt gttcacaatt gtaccttccc tttcaccacc agacatggca 76920
actcttccac acagttgtca cttacagagt cttacatcaa tgaaatctgg ggtgaatgtg 76980
ccatccaaag aaacacagga accagagttg ggttccagga acccatgaga aaaagcttgg 77040
gtagtagcat acactggtag ttccagccct gggaagacag aaacggtgaa ccactgagat 77100
ttgtagcaag ccaacgctac cttttctcac atttagccct acttggtgag cccaggccaa 77160
tgagagaatc tgtctcaaga agcaaggtgc gcgacatgtg aggaagaata ctcaaggtct 77220
cctctggtct ccacatacac acatgtacat acttatgtac acccacacat aaatttgctc 77280
ctccctttgg acacatgtcc aggagtgttt agaaactgga tcacatacca tgtaacctcc 77340
agagactggc ttttttctca ttgatgtgaa tgtagcatag tttaggcatc ctcacgctga 77400
agggcttttg gatcattttt aattgaagct atttacaaat aacactgcaa tgaccactta 77460
agaacagtat cgacatggat ttttatttct ttgacaaata tccaggagca ggatcgctgg 77520
gagtattagt tacttttata acacaccgca acaaaatcag cttttgggag ggtttatatg 77580
gggcttataa aggaatgagt ccagcaccat catggtgggg aagcatgtct ggaggcagga 77640
atggtggcta aacagcagct gagagctcat gtcttgaaca ataaacaaga agcagagagg 77700
ctaaatttga aatggcacaa atcttgaggt cttaaagccc atccctagtg atgtattcct 77760
ccagcaaggt cacacctact aagcctcccc atacacccat cagttaggga ccaagtattt 77820
aactgcccag accatggggg atatctcatt caaaccacta cactggataa aggtaagctt 77880
aatttaaatg agaaatgccc ccgacaggct caggcattgc acacttggtc tccaattgtg 77940
ggcactattt ggggaggttt gggaggtatg gtcggtcctg ccataggaag tatgtcactg 78000
ggggagggct tcgagaatat ataaccccgc tccacttacc atttgctccc tctctactgc 78060
ttgtttgtgg ttggagatgc agtcagtctc ttggttccct gctcctgcca ccatgcctgt 78120
cccttgcaga cggactcttc tccttccaga cccaaaagct aaaaataaac tcttaattcc 78180
ataagttgtt cttgtcatga tattttgtca caacaacagg acaattacac ccctctctcc 78240
ccaaggttat ataaatagta aggacctctg tggagacagg attatttcca gtctgttgtg 78300
ttgtctgcaa atcatgtaga gagctcttgg gatacaccct tcatgagtca tcacctatac 78360
tcagggtttt tgagtaatgc agtattgtac ttgtattgtc cagtgttcct gtcagtaagt 78420
tctcacccat aattctgtaa gtaatccaga taaacacatt ggcttttgaa tggacacttt 78480
ggtaggatag tttctttagt ctgtcattgg tgctttatct gggctgagta gatgtttgca 78540
tgaagtctac actctttgtt ttttgtttgt ttgtttgttt gtttcaagac aaggtttcta 78600
tgtatagccc tggctgttct ggaactcact ttatagacca ggctggcctc gaactcagaa 78660
atccacttgc ctctgcctcc cgagtgttgg gattaaaggt gtacgaacac cacgcctggc 78720
tgaagtctac actcttataa aaaaaatagt cctgttctca cttcatttct gttgctgtga 78780
taaaacacct tggccaaaca gaacttgggg aagggaaggg gttcattatg gcttacagtt 78840
ccaggttctg gacagtcgat gagaaggcaa gcttagtcac ctcacacgca tagtaaagga 78900
cagagaaaaa tgaatggatg cctgctgcct gctgcctgct tgctgactgc ctgcttctgt 78960
ttatcccctg ccataaaata gttgagaacc ttctgcatag agaatgttgc tgcccacact 79020
gggctgggtc ctcctacatc aatcaacaat caagacagtc tcccacagac atactcacag 79080
gatctaggca atttctcaac cgagactctc ttctcaggtg attctgggtt gtgacaagtt 79140
gacagttaag gctaaccatc acagtgtata ttagaactta tttgttctaa taaacttagt 79200
aattcccatg ggtcattagc tctacctggt aggaactatc tttgtacact ttgttaatac 79260
aaattgacta cttgttttaa tacctcatat aaaatgacag ctgtggcatt tgtctttcta 79320
tgatagagtt atttcactta gcatgtcttt aaagtttatc tgtgttctca tgtattacag 79380
aaatattcat aatgttaagg ctgaataatt ttcatgtgca tgtgtacaga cacatgcaca 79440
tactttcttt gctcatttgt tatgagggat catacaggtt gtttccttaa gttggctact 79500
gtgaatagag ctaccatgaa gatggggtga aaatatctgt ttgtgatatt tagaatggct 79560
cttttgggta aaattctttt gaatactaga tcatgtaaga gtccaatttt taattttgaa 79620
aaaatattta tttttatttt gtgtgtatgg gtgctttgct agcatgcatg tataccacac 79680
gtgtacagta cctacctgca gaggtcagaa gagggtgtta gatcccctag aactggtgtt 79740
acaggctgtt acgagctgct ttatggtgct ggcaaccaaa cgtaggtcct ctagaagttc 79800
agacagtgct cttagccact gagccatcat cttctggatg tatttttgag aacctactat 79860
actcttctga catggcatat cattttacat tctgtcagtt gttcaaaaag cttggagttt 79920
ccccatatac tcattaatac tggtttatca ccatcatcat catcatcaac aacaacaaca 79980
acaacaactt tattttataa tggtaattgt gacagatgta aagcaatatt tcatgttggt 80040
tttgatttgc atctttcaga tgtcagtgac tatatcctcg tgggtcactc atatgacttc 80100
actgtagaaa tactttaatt atttaacccc ctattcctcc cctctccact ttttatagta 80160
atgagggttg aacccagggc ctcatacatg ccaggcaaga acattacccc tgagttgtat 80220
cagtcagccc tactcaattt ttcagcctct tttaacatca agatagtaaa tgtgttgctg 80280
tttggaaagt ttggggattt tattacatct tgggagttcc ttatatactt tgataattaa 80340
ccccttagtg gctggatggt ttgtaatatt tttatccttt ttcctgagtt gtctcttttt 80400
tctgttaatg ttttctttcc ttatgtgatg ctatattggt ctgaatgaga agtgttccct 80460
gcaggcctga gcatttgaat gcttggttcc tgtcttagtc agggtttcta ttcctgcaca 80520
aacaccaaga agcaagttgg ggaggaaagg gtttattcag cttacacttc cacactgctg 80580
ttcaccaaag gaagtcagga ctggaattca agcaggtcag gaagcaggag cttatgcaga 80640
ggccatggag gcatgttact tactggcttg cttctcctgg cttgctcagc ctgctctctt 80700
atagaaccca agactaccag cccagagatg gttccaccca caaggggctt ttccgccttg 80760
atcactaatt gagaaaatgc cccacagctg gatctcatgg aggcacttcc ccgattgaag 80820
ctcctttctc tgtgataact ccagcctgtg tcaagttgac acacaaaacc agccagtaca 80880
gttcccagtt ggtggtgttt tggggggagg tttggatacc acaagcttgt tggagaaaat 80940
gtatcactgg gagtaaactc tgagaacaga tagtttccca catgtctagt tcatacctgc 81000
tgctttgtgc ctgtggtccg agacatggct ctcagatctc tgctcctttc accatgcccg 81060
attgctgccg tacctcacac catcatggac acttatccct ctggaaatca tgaggcaaat 81120
aaaatcttct tcctataaat cgccttgtac tcggtatttt atcacagcaa tagaaacgga 81180
actatgtaga tggggtccct gttgtctact tttgcgtctg ttgcctgtgc atttggtgat 81240
gtatctatga aatcgtagcc aagaataaag gcaaagctct ttccccatct gttttcttct 81300
gaagttttat catctggggc atatctttaa gtctctaatt catttagagt ttgcttctgg 81360
gcataactct ttttctcaat atggcagtgt tggggactga acccacagtc ttgtgcatcc 81420
ctggtgagta ctacttcatt taatgtttag agaagccccg actattccct aacctgactc 81480
tccttctcag tcaagttttt attgatggac gcagctccag tttgtatcag agaatgaagg 81540
ttagcacagt atctgttttc atggaacttc tggtaaaata tacatccata ggccaatata 81600
catgaaaaac aactacaccc ctgactgcct tcaccaacct attgctggta ttttatttgt 81660
gatagttgga ggtagggtgt gtgcctgcca ctgcatatgc gtagaggcca aaggacagct 81720
ttgtgagtag ttctctctta cctttcttag cttctaggaa gtgagctaag gtctgagggc 81780
ttgtgtacaa gtattttatt tgctgacgca cctcaccacc cttcattacc aacatttcaa 81840
tgttccccag ctgtatatta aagggcccaa gaagtctata atgcagtaac ctgcttaaca 81900
tcactgacac agaacttatt aaatttgcat gacaatgtaa aacatacgga ttagtatata 81960
atttaattta aagaaatctt aatttgcttg cttttataaa tgcaatttgt taaattgcct 82020
catggaacag ctattttctt cagaggcaaa taaaagagac actaatattg gtaatcctgc 82080
ttcacccagg aagagcactg gtcctagtca ggagtccagc accgccgtca ctgttgggta 82140
tgtctttaca tttaagtcaa gttcagagtt cagagtaaga gactatccca gatgctaggg 82200
tggctttgag ggttctgaga acccaaaggt cacgtgaaag atatggttac tattgtcagg 82260
ctgattctaa tcagaaatca gagtctggag atggagcaga taccattgag aagcagttag 82320
gaggtggtaa tgtggcactg acaacccagc caaggctcag gtagcggtgg acatgcgcat 82380
ttgctttctc ttgtgtttat cgggcaacaa gcctgggtga actggaaagc ggatgcggtc 82440
tgaaggtctg catgaaacca cagatgtcga tccgtggggg gcagactccg ggggcatgtg 82500
tctcaggggt atagcacttg gaggtggcaa ggactaattt caaggtctca cactttaaaa 82560
gcctaaagtc caagcatagg tgggagccca gcctagactc agagcgcaga cgcggacaga 82620
gagcatgcta ggagcctctg ttggacagtc aaacatgacc gagtaagacc gaaactccat 82680
agagacagac tgagggaagg gagaggttaa agacagggaa cctgggctct aagatctccc 82740
tgtaacagct ctccctttgt aagattggat cgaatcccta gggtaagggg cacagctgag 82800
cttccaggtg agacaagagt agggagaaga accatcaggt aagacaatat agttagagcc 82860
ccaaaccaat gaaccaacta accaaccaac caaccaaaca aacaaataac ccaaagacca 82920
aaaaaaaacc cctaaaaatc aaaacccaaa ccaaaaaacc tcaaaacaca aaacaaaaca 82980
aaaagaccca tgagccacag gaggaacaca gttctgtgaa ccctgggctc aaacaagggt 83040
atggatagaa attaaatgtt atatggatgg aaggggacct ggagaaatcc cagtgttttc 83100
tcttggatga agactcttga tccctgaaac taagtctcac aagcccagat gaagttgtga 83160
gtttaaatct tgtcaagtgt gaaactagag ccaacagtca aatgcctccc tccaccagct 83220
aaaccagtcc attttaacct gtggattaaa ttgtggttta attttaggcc agaaaaaaat 83280
ttttacttgc cataaattta agtgctttag atacccatga cataaagact ggagcattat 83340
gtaaaaggga ggcacattag aggtcattta atgacttgtg ccacttcaga gctttctatc 83400
acatagtcca cagcaattca aagtcatgac ccctagaact aaaaacatta cccatcagcc 83460
tttgaactct gaaaccggcc aagtgtaata agcccagagc aaagtacaga ctttccagtg 83520
actgagcaca ggcagtgact agaccagatc ggccatagtg agaccacaca ctggccctac 83580
tcagcgggca ttcactcagc ctagattcca ttttggttgc tgctcaccta gtctcaaaaa 83640
gtctcagcta agtgatgtga cagccctttg tgctaggaca tgatctgttc taaatatctt 83700
tccacaggtg tgctgcaaat caccgtcaac ctgataagaa caatccctac aataaagtga 83760
gttatttata ccaacatcct cccatgttgt tgaaccaatg aagcaaatgt ggaagaataa 83820
tgtttggctc ctttctgttt tgaaaacatt ttctgggaaa gcaggtgttt gcagactaaa 83880
tagatatgca tgccatgggt gatagatagt cttagatgtc aggtcagttc ttcatcgggg 83940
acagatcttt ggaggacact gtaatattgg tcatgacaga atagattctg atagaagttg 84000
gtgtctaaaa tgaaaatggc ttggagacca caggtgatcg gggagttcct catggctgtt 84060
acttatagga agaattcttc cctcctataa gccctgctcc atccagctcc caaagatcaa 84120
ccagtattaa gactgacgtt gtttaaagca ccactatctg tccctgtatc tactccaacg 84180
cattgagcca gctatatagc actttttttc cgttccccaa taaccctaaa tttcttctac 84240
ttcttgttgg agatgtttcc tttgccccag atgtctttca tccatccact aagtacttcc 84300
atcccttcct gtactagcta attctttcct cccctccaag actcatcaca ccaccgtgcc 84360
ctccaggatg gcttctctca gtcctcactc atggactgag aggtgctccc acctcacttg 84420
cctggtaggt gctcccacct cacctctgca tgccaggagc taagaaaagg aagttagaac 84480
attactagag attcgcttgg aaggaaggca ggaactgaga tggaaagatg gggggggggg 84540
gaatgataaa ccatatggag ccacatgaaa cctggggttg tgtgcagtaa ggggtgaaaa 84600
gggatctggc taactgggtg ttctcaacgc aaggaaagtt cataagacaa acccaaatga 84660
gaccattaat actgccaggt acagggcaat gtctacaaca acgacgatac agaataaccc 84720
gtggcctgga gaggtggctg ggtacataga gtgtttgcta agcaaacagg aggactggaa 84780
accagaactt taggatcata tacattccag atgagcctgg cagcccacca ataataccaa 84840
tactaattag gcagaggcaa ggggagctcc agggcaaggt ggcttgctga actagcaaaa 84900
tcagcgtgct ccagattcag ctggaaaccc tgtttcagtg aataagatgg aggcaataag 84960
acatccagtg ccaatctctc tttcccacat ccacatttgc ttggtcacac aggagtatcc 85020
acatccatcc acatgcatgc atacacagcc ccacacgcat acacatgtgg gagaaaagga 85080
aaaaggaaag aataaagtag gtagacatga cgtcgagaag caatttaagc agggtggatg 85140
tgttttctgt ccatcccttg tgtgtttgtt tctctttcct aagctccact gttcattagg 85200
ggaaagttca actcacataa acttttcatg tcttcttcag atatcctcac cttgagatga 85260
tgtagtgagt agggtcttgt gcacaaatcc ctcagggttt ggagtggggt atgggtgtca 85320
aagggcacag gtgaaacaaa cctggctgtg cactgattct tgtagggtct agggttttat 85380
ggggtgcttc tacttttggg gggacttgac aattattcac aacaaaacta caaaacagcg 85440
catcaggaac tatgggttct tctcaagtgg agggcattac atattaactg aatgcgtaca 85500
catgccttta agatgggata tgcatatgca ctgtctaaga taccccgaga aggcactggg 85560
tatttcagat gctgaacaca gattttccta agctcttgcc ttcaggccaa attctgcttt 85620
tcctggacta tggcactgtg cagagaaaaa ttatttgagg gcaaggtggt gagaagtctt 85680
aaaggcccca tagccgagga tggggtaggg ctgtctcttc tcctgtgatc actgaaggcc 85740
tcttatattc aacagacacc aaatctgaga ggtcctacca tggccaaggc catatcccct 85800
ttcttatgtt cagagatgga aaaggaggat aatcaaagtg cttaactcac agggtcatta 85860
gtaccatgaa tgtgttaagg tttagtccag tgagttgtta gcatcgggca tctgtgcttt 85920
actatcagag ttagtgtttg cgttggagtt agtgttatgg gtcaatagtt accagttagt 85980
cagacacaca ctatgatgga taggttgttt atagacagag agaagacatg gttttctgaa 86040
tataagacgg ggaaggagta ccagggctag gaatgagcag agaaactatt tgaggatgca 86100
gctgtgtata atttaggcag ggtgtgtagg ggaggggaga gatgtgaacc aggaagcaag 86160
gcagggctgg atggatgatg gtgggcctgg catggggcag caaagttgag acttgaagca 86220
ggaggccccg aggagccagg gagtgacctg gtccagggag gggcgagatg aaaacatact 86280
tcaggaggat taggctggca tgagatataa agtgtctcgg ttttgggcag gttcagacca 86340
agggtcgaga agtccctaca gagctggaaa tttctagact tcctccagcc tcaggctcca 86400
agctacattt ttgccaggct gagtgggaat cctggagttt tccatgggac ccaacaattc 86460
atctttgtgt cttctgttac cctcagcttt gtttttgtgt tgcgtaacat ttccaggtct 86520
caatatccca agcaagctgg agttttcaga ggttaaactc tagaacctac ccagcctggg 86580
tggcatctct ggaagcaaaa agagacaccc cccttttgac cagagatcct tgtagacaaa 86640
tggccttagc tgaccctggc tgttctttgg ttcatataac aatactcctc tcctctctct 86700
agtccttctc ccaacctgtt tagacacaag acttacataa accttctcca ctcccctctg 86760
cttcttcagg tggaaccttg aagaaaaaaa aagttgttac taggccaagg agcaaggttt 86820
ggaaagacac gatgtgctgc caaatccagg aaagcaagtt aatgagaagg tgagactctg 86880
tccacccact ttctttcatt ggcggaattt ttaggtaaca aacatagctc caggcaggtg 86940
tctgtgcccc actcccatgc tgagcaggag ctggacccga gctgcaggtc ccactcagcc 87000
attcagtggc ttcatctctg caccatctcc agacccctat gtccaattgc acagcagtga 87060
tccaggtcct tccctctcga agtccttttg agctctagct ttccaggatg cccttctacg 87120
ggtcagtgtg ttggtctgga tgagtcctgg gtctgaccag aactactctg aaagggaaga 87180
taaagaaaga gccttagaag aactagctgt cctaacaaca ggagaccccg tactcacata 87240
ctaatgtgca ctcatgagct catgtggaag tatacatata agcaacactg gtgagcacat 87300
gcacacacac acacacacac acacacacac acacacacac acacacacag catgcatgca 87360
tgcacgtaaa ataaagctta taaaacaaaa caaaacaaca ccaagaagca agcaagcaag 87420
caagacctag ggtttttata catctgttgt gggattgttg ttgttggtct tattgtgttt 87480
tgcatttttg gtttgagaca ggttctcact atggaaccct ggctgacctg gggactgcct 87540
gcctatgcct cccagagtgc tgggatcaaa ggtgtgtgcc acccatgccc agctgctgtg 87600
gattttatag gtcgttgatg gctgggtttt ggttatgagt ttaacactgc tgttgaatgc 87660
agagagcctt ttaaatcgag catcaatgag gggttgtttt gttactgagg ggctggacat 87720
gggtttgctt aggactgaga tttgctttct gttgcctccc ttgttctgag cgcaattgct 87780
tagctagatg tcgatggcct ttcaccatgg gtttcctgtg agcgttacaa gctgagattg 87840
gcaggtgcat tgaggaggtg ggcaagggga ggggcgacag cacaatgctg tttccctatt 87900
ggtgctaagt gctgttcctg tttaataagt gcagttttga actggaagag aggaggtgtg 87960
aaaacaccac acgagtcccc taaaatagcc tcttaacaac caaatcagga gtagaatctg 88020
gtctccgttc aggaaacagg gtgcttggat gtccactccc ctggggctcc ttagcccgtc 88080
tttcccctta ggttcaaagg ttcttcataa cctttgggtc cattgacttt acttctgata 88140
atatcaatga cctggggaca tccaccttac atatgaagga cccctgtcgg catgagtagt 88200
tgtctattaa ctgtcaccat gtagtcagct tctctggcag agatgattac aatctaagtc 88260
tagaatgctg ggacccttta atacagtttc tcatattgtg gtgaccccta atcttttttt 88320
tttttttccg agacagggtt tctctgtata gccctggctg tcctggaact cactttgtag 88380
accaggctgg cctcgaactc agaaatctgc ctgcctctgc ctctttgttg ttacttcata 88440
cctgtaattg tgctactgtt atgaatcata atgtaaatat gtgtgttttt gatagtctta 88500
gcccctatga aagggttcct tgaacccccc aaaggggtcg tgccccacag gttgagaacc 88560
agttctctaa agagccattt atgaccccct ctttggctat caggcttcta aaagaatttc 88620
cctaggaatc tccacatggg agaagaaata gccaaaaccc cagggacatc cagaggaaga 88680
cctaatgttt tgtgaagaat tttgcaactt attagatgac ttcatagaga gttggcgctg 88740
agacggccgt gggcagaggc cacaccttgt ctgaactatt caactatgca tatcttttct 88800
ttttttatgt accctcacgt atggaatttg aaatcaaact tggatgtagt ggtcactgta 88860
tttcctttgt ccctctttcc attgtggcca ctttgaataa atctccattt taatttggct 88920
cttttatttg gcttgttcag gataggtggc caaacctggc tagttggggg ctcaggttga 88980
aaccctaatc tggtaatagt aacatatgtc ctgagtctgg acctgtacag ccatgctcag 89040
taatgaagaa caagcagcat attggatctc tcctaagggg tgaatttcac ccctgctaaa 89100
taagcaataa ttgatcaaac aaggactggc tgcatgcttt ttatgctcct cagtattcgg 89160
gggcagcctc ctctttttca ctactccaaa ttctcattct gacttgagct tagagttgtg 89220
tttactccag actcacgcgg tttcccttga ttattattgt gtgcctctcc ctctgaagct 89280
gaagaaatag ctgatcctta cgtgcttgtg gagtaagcaa agaagtcaca tgactggatc 89340
agtacaaaaa tgtattccgc tttgctgtag tccagtgaat ttgaagccat ggatattttc 89400
ccttttaaat gtacagttca tgtttagaga aaggaacgca acgatgtatc aattgcttgt 89460
atacttactg tcaaagtagc agaagttaac atttaggctc agtacttttg aatttccttc 89520
tttcttgaag aaatggagca ttacattcat ttccatctct actgagaaaa ccagggctga 89580
gtggccagcc atgtgcttgc tgtctaaaat gcactgatgg ggactggaga gatggctcca 89640
tggtaaagtg tttgttctgc aagtatgaga tcttctgtct agacatccag aacaacatct 89700
aaaaatatct agatgtgatg gtgccttcct gtaaccccag caggggtagg aagggaacaa 89760
gtggatcctt ggggctgtct gatcagccat ttcaaagaat cagtgagatc catcatgaat 89820
gagagaacct gcctcaggaa gtaaagggag aggctggagc aatagctcat ggttaaaagc 89880
actggctggt tccagctcta gcagcaatct acacggtggt tcacaagcct ctgtaaccct 89940
agacctagga tgtaatgtgc ccttccagtc tccaaggata ctgcatgcat gcatggtgca 90000
cagacacaca tgcaagcaaa tacccaggca caaattaata ataatgatga tgatgatgat 90060
gatgtagata gatagatgat agatgataga tatgtgataa atagataata tagatgacag 90120
agataaatag ataataggtg atagatagat acctagatgg atagatagag ataatatagt 90180
tagatagata tagctagata tagtatagat agataaatag atagagatag ataaatagat 90240
agagatagat aaatagatat agtattgttc aatagagata gataatagat agatagatag 90300
atagatagat agatagatag aatagtatag tatagtatag tatagtatag tatagtatag 90360
tatagtatag tatagctagc tagctagata tgagtgtggt agcacatctg ggaggcagaa 90420
aaggtctgca agtttgaagg cagcctggat tacaaagcaa attccaaggc tacatagtga 90480
gacattatct tttaaaagta catatataaa gtaaagcaga agcagaaata aggaaggcac 90540
tgcccgttgg cttttgtcca catacacgta cacactctta ctcacatgtg cacacatata 90600
accagggcca tacagaatac acacacacaa agtctaagaa tctagggcca acgagatgtc 90660
tcactgggta agggcacttg ctgctgagct tgatgacctg aggttaagcc ttgagaccag 90720
ctctcacaga ttttcctctc atctctacgt gcatgcaagt gtgtgtgcgc gcacgcagga 90780
gtgtgcatga gaccagtaga ggggtctttt tgtccattgt catcactgtc ttcaaatcag 90840
ccatatcagg cacttggaac ttgtcccttt catatacttc cttagaaatc cctccgttca 90900
atgtcacttt tctcatttgg actggttaaa caattccctg gactgttctc tagaaagaca 90960
gatgtgtgaa taattaactc aacctcatta atcagttgct accccggttt ctaagcttca 91020
aagctgagtt acttgccctt agagcataga attggtttat aaatggtgta tgcattcatg 91080
tatgctaaag gaaattatac gttttataga actgagaata tgtaaagtat ataaaatgta 91140
ctgtgaaaaa aattaagaag atagagacga ctttttaagc aaattcaaag agcttaaagt 91200
cttattgtag atagtgtttt aaattttttt cacttataat tattgtgttt gtgtgtgact 91260
gtgtgtgtgt gcatgtgtgt atctgttcat gtgcatgttc cacagtgtgc atatggaggt 91320
cagagggcaa actttcagag ttcacgttcc actgtgtact cagaggctca aattcaggta 91380
gtcaggcgtg cacagcaagc atctttctac accgagggat cttgcaagcc caagtgacat 91440
catatcgata ctcttaaaag tcattgcctt caagggcaaa ggtgatgtca taaaaaagct 91500
cgtgcttaag tcagcttaag tcagagagca gcctgcagag ttctgtgctg ctgacaccgt 91560
gctcattgca ctaagcctgg aactatggga agctcacaga taaccaatac acagacagtt 91620
ccctgaagac tgtagtcaag gagacgggtg cacacagcta aacagaccac aagccagcga 91680
agcagatgct gtgacagtca cttaaaggac atgctgtggg tgagactagg gagctgggag 91740
taggtgccaa tacagcaaaa ttccttgtgc ttaccaaatg gtccatcctc actgtcagat 91800
ggcaggggca tgcaggacac agtggtggtc tttgacttgg ttatgaagga tgaaaagact 91860
tcaacaggaa gacaaattgg ggatgaagat gtaggcagtg gagggaaagg agaagcagtc 91920
taactggggc tgaagagata accagaggac acagtgttgg atattttcac tgagattaat 91980
caacagttca gtctttggtc catcagcccc tcctccacac acacatcccc cactcgtttt 92040
tttgaggtat ggttcacgtg ttccaggcta gcctcaaact caccaagtgg ttagctgaag 92100
atgaccttga actttagact ctcctgcctg tacttcccca gggctgggat gacaagtgtg 92160
cactgccctg cctcaggtgt gcactgccac gcctggcttg tgctgttact agagatggaa 92220
cccaaggctt ctggtgttct gggcaagcac agcctggctc acatccccag ccctggtcca 92280
ctcttgtctc tttccacagt gatctatcta gtcttggtcc cagcaccttg ctcagaggga 92340
gtggtcaccg atgacctctc cgctgtttac ctggatggac cctccttagt ccctcattcc 92400
ttggcctctt gctgatgtca cttgtcacgt caaccttgat gtcgatggcc acactgacat 92460
ttgggtccct tgtggtcttc atctgtaaca tcctgtccac cgctgtattc tctttgtttt 92520
gttttgtttt gttttgtatt ttcgagacag ggtttctctg tgtagccctg cctgtcctgg 92580
aactcactct gtagaccagg ctggcctcga actcagaaat ccgcctgcct ctgcctccca 92640
agtgctggga ttaaagacgt gcgccaccac tcacggcaat attctctttt atctatgttc 92700
agatgccttt tctctgtcag ttcttcctca tcttacatct ttatgagcat gtctcctgca 92760
gtcttaagga catgccctct cctacaccat gcctgaattg ttcatatcta actttcaggt 92820
ctcatcttaa ttattactca ccttaggaac agtttcccca aactttgcat ctgtccagta 92880
atgagcctag agataaaact ttatcagaga taaatgcctg agtacccagc tgtcttccta 92940
gattagccca tgccattctt tagtttcttt ttttgcataa cccgattata aatgtaaaag 93000
tcatgtttac cataatattc ccagcactta acacaggcta atcaatatca agttcttaat 93060
aaatattcaa tgagtaaata tgttattcag gcaacatcaa gaatgctggg ttgaataagt 93120
agggttatat aggaagaaac aagagaagaa ataggctgga tgaagaactt tagctttcca 93180
cttcaaacat ttaaggctat tctacagata aaactgctat ttaaagttgt ggtccagtct 93240
tcctctagta acatgctttg ttagctggtg tagtgtaacc aattagccag tttagtcaag 93300
ggttagcagg gtagactaca ccacaactgt aagagcagca agacagaagg actgaacagg 93360
gatggtgccc aagagaatgc tgggagttga tagcgaggca aggccccatt cggcatcctt 93420
ttctgccctg ttatcattca ctaggagaaa agagtgccta aggaaagcca gacttagaag 93480
gaagagaggc agagagctca tttcctgatg cagaatcagc cggcaggata ttagtctata 93540
gctcaggggc tccctgagca ggagctgtgg atttgagaga tatttgggaa gaactattag 93600
atgaagatgt gagggttgtc aaggaaagca gacaaaggga agcgagtcaa gagctaggca 93660
tgtgtatgaa ctcaaatagc aacaacaaca acaacagcaa caaatgccat gtatacatgg 93720
aagagctcgt ggccgaaatg acaaaggaaa caaatgtttt aaactaaatt aaagaaatga 93780
tcacgtttag atattgtgct taaaatcttc aggaggtgaa aggtgatctg gaagctgaca 93840
ccgagcaggg gcaaaaagag agcatgtcac agttaggttt agtgggtaga aggtaacatg 93900
gggatgatca gagaaccact gaagtggggg aggggtggtg atatctttgt tcttcagaca 93960
cagaagagca gaaacaagga ctcaggcatg cgtcgtgaca gggttagagg cttggttagg 94020
tagaaagtta ggtttccatg tgtccgggga gcggggagga gaagaatgtg ttcagggcaa 94080
agatccaatg tataaacttt tatggccaac agaatgaggg ctctcagcta cagaggaaac 94140
acttaatccg cctgtaaatt tcagtccgtc atactaacct gacatggcag ctggcgtcat 94200
cgggacatga gcaatggttc caagcagagt tgattgtgct tcctcactct aattattaac 94260
cagtcactgt gttagctcat tcacgttgag aagcctcccg cctcactacc catctgtatg 94320
gagacttctt ttctacgaaa gaagtatgct cattccaaat aacatcaagt gtccaaatca 94380
ttagttttta ctctttgttt tcatatgcta tgggttaagt gcagagctat taaaatacaa 94440
aaaaaaaaaa aaaaaaaatc tggaatgagc cctgacaact gacttgattc caatcttatc 94500
tgccattttc tggctacatc attgggagac ttacttaacc tctcttaggt caaactacat 94560
tattggatgt ttcagcccat tctaattttt tttcttttct cagccttttc aatgtgtatt 94620
tactacttga acgtttttca tttaaaaaac aaacaaaaaa aattgaaaaa actcccagaa 94680
catctgctat gtgtcagcta ctgaaggaac acaatgttta agacctaggt tcctctcatg 94740
agtcctaagc ttgctttagt aggcagtgac agaaggacaa actggtccat ccatctagat 94800
aaacttcgga aagtgaccgt gtccatggga agtcctcctt agacactgtg acccttgagt 94860
tcagcctcag agaatggatc caagttaatt gtaggtgtgg aaggttgtgt tttgacacag 94920
gggacaggca agtgacaaga aggcactgag ttcaagggca cagtatattc taagtgtcag 94980
ttgccagtgg ctgaacatag aggagggaaa gaggttagag aagccaagtt caaagctcag 95040
actatgcata cagtataagg ttaaggcact gatcctatag ctatgttacc tatgaatgag 95100
tggtcgttct tgggcaaggg acataactca ataggttttt cgcttttcca gctgtaaagt 95160
ggaattgaaa atggtatggc atagcgacct cacatagaag tattcaaaac aatgtctagg 95220
gcacggttat ggttatggaa gcctcttgaa gggctccagc aagtagagat ttgagttgca 95280
ggcagaggca agcgaagagt ggattggaga gccgtggaaa cgggagtgga aagatgttag 95340
aaaaaaaata cagcctgcac tcaggagagg gtatggagat acaggtgaag cagacggctg 95400
gtgtcagtct tgacagccca tcaggtgaag ataggatgag cggtaactaa tacccagagt 95460
tctacttcga acacatagtt ttctgtttgt accctaacta catgcacgcg cgcgcacgca 95520
tgcgcgcacg cgcacacaca cacacacaca cacacacaca cacagataca tacacagaca 95580
gacagacaca cataaacaga cacacacaca cacacacaca cagagagaga gagagagaga 95640
gagagagaga gaaatgacta tatcataggc tttggggcag ggacaggtgg gcctaggtac 95700
agagtcctaa cttttatctt gctttctctc tttctttctt tctttctttc ttcctttctt 95760
tctctctctc tctctctctc tctcccttcc ttccttcctt ccttcctcct tcctcccttc 95820
ctttcttctt tctttctttc ttctttttct tttttctttt ttcttttttt ttcttttctt 95880
tttgtttttt cgtttttttg gtttttttga gacagggttt ctctgtgtag ccctggctgt 95940
cctggaactc actctgtaga ccaggctggc cttaaactca gaaatccgcc tgcctctgcc 96000
tcccaagtgt tgggattaaa gacgtgcgcc accactgcct ggtctacttt tattgatttt 96060
ttgatatttt ccttccctca caaagaagtt gacaaacagc ctggcagagc tgtgagaact 96120
gaatggagac tgagtaggaa ccgtgccctg gatggtgctt ggctctcata cctcagatcc 96180
tcagggaaat gggctggact ggggcctaga gcactgaatc ccctggaagg cccctgttga 96240
caaaatctct ccccaaaccc gacaaaagca tcacaaactg tgttcttccc agcacctaca 96300
ggagctacac cttagaacac ggatgtttcc caggtgttct tttactgtcc tatttctagg 96360
aacccgggac tcgcacttgt ttgaactcta gggcgtttaa gaagtcactg ataaggcaga 96420
gccagatgga ggtgggatga gcaagaactg ctactctgaa gagagggaca ggtgcacaga 96480
agactaatgg ctcagtagac agaaaaccca cctctatcta cagataagcc aggtgacaac 96540
attagcctcc tcggcagctg tcccctcttc tgctgagacc tatcgattga catcctaaat 96600
gtcactgtga aatgttcaag ggatactccc cacttagcgt agctgctgag ccagggaagg 96660
caactgaatg tcttatttga atgggttgcc tggtgctctc cagaaaggtt ccaggctggg 96720
acggaacctt cccaagtgaa gaaactcact tcacaagcct ccagtccccg ccctgcaaca 96780
agcctgtttg ttaacttgaa cttgcggtga cacacaccga gttcatttcc agtttgcgct 96840
ccagggcaag tccttgacta cacaaagagt gagacagttg gggaatttgt ggactgtcca 96900
gttaatcaga taaaacccga gagagtcaga aaggcgactt cttggaagat gtcaaagttt 96960
tactgaaaac agcggaagtg ttcgcagcta attggtgctt tccttccaca caccccgcac 97020
tccctaccgc cccctccctc cccgcctccc atccctgtcc agtccccacc ccctgaagtt 97080
tgtctttggt aaaccccagc tacttctctc acttgtctct gaggcacaat gggagtcttc 97140
atctgaattc tagggaagaa aagatatgac tccttctagc acgagtgagc tggattgtaa 97200
cagggaacga attgattgat ttttcccccc cttcatctca atgaacacac tatgtagcca 97260
aaccaaggct gatcaacaac actcaataaa aaaggagatt caaactgagg cccagctgag 97320
ccctactaga cctccacaat gcacgctgtc atctgcttct tacatgtcat cacatttaat 97380
tatattaatc ttcgccataa gtaatggagg ggattattat gagccttggt ctagcaactg 97440
ggttcaaggt cacttagcta atatgtaact ctaaatgtta caagtttcta agccaaggat 97500
atgtcctttt ctcaggccga tgctgtcctg ctggccttct aaaatgttag ttctctgcct 97560
cttgttctgt gcctacctca gtgccccacc cccactcctg ctcccccccc ccccattatt 97620
ctgatcacat ttacattccc ggtctcccat tctcctgatc ctgtgtgctt acatcagcta 97680
gaaattatat gcaggacttt taaagagttt ttttcatagt attgcctttt tgcatatata 97740
tatagtgttc tttgtttgtt tgtttgtttg tttgttttca aaacagggtt tctctgtata 97800
atagctttga ctgtcctgga acttactaca gaccagtctg gccttgaact cacagacatc 97860
ctcctgcctc tgcctgacct gtcaagtcct gggattaaag cttgcaccac cacacccagc 97920
tgcttttata gttttttttt tttttaagtt gtgtggtgtg catgttgttg tgttttataa 97980
aatagctgtg gtataatgtt tggggatggg gaacatttca gcaggcctct gccaaggcat 98040
accccttgag gaatcagtca taccacaggc ttagtataaa agggataggg gacctggaaa 98100
aggggcagag gcagagaagg tgggggacag aggaggacag aaagagagag aggccagctg 98160
ggaacatgtt ggggagagat agagagaggg aggaagggaa ggagaaaaga gaagagagag 98220
agggggaggg agagggagga ggagatgaag aggaagggag ggaggagaga gagagagaga 98280
gagagagaga gagagagaga gagagagaga gagagaggga gggagggcaa gcagtccttt 98340
ttatacacca ggttggctca cacttggcaa gcctcaagct gttgctagga agctgttgga 98400
tggagcctaa aggaactgcc aatagtgtgt gtacagatga gtttgtgtgt gcgagtctat 98460
gtgtaagcat gcagaggcca aagatatcgt tctatatgac agggcctctc actgagcttg 98520
aagctagtca ttttccccag gctggctggc cagcaagctt ttggaatctg cctgtctctg 98580
tcctccaaag atgtggttac agggatacat ggtagtgcct ggcaatgcct ggctttttat 98640
gaggatttga agtcaggtcc ccctgcttgc atagtaaatg ctcttaccca ctgagccatc 98700
acctcagact catcttatta attgtttcag tgtcgctgta tcgtggacac aaacatatgc 98760
atgtatataa tagggggaga gcagattatt ctggcatttc gagatcctag cccagtgcag 98820
gtgggtggca gtattagcaa aatcactctg atctgatatc tgtttattca tgtattctta 98880
tctaagtgtt ggaagaagaa atggcacgag aaagcacagt aacttagttc acagtcacaa 98940
agcttggcaa ctcctagctg ggtggtgaca cgggctgtac ccctatcatt caggaggctc 99000
aagcagaagg ctcccgagat gggagctagc ctgggcgttg gagtaaatcc cagggtaact 99060
ttggcttgtg tagtgagttc ttgttttgag agactcacgt ctggggagcc agagcagtag 99120
ctcagtggtt aaatgtactt tctgtgaaat cataaagatg ggagttcaaa tcccagaacc 99180
tgtgtactga catactgggg aaaacctata aggccagctc tggagggagg tggaggcagg 99240
aggattgctg gagttagttg gtgtcttagt cagggtttct attcctgcac aaacatcatg 99300
accaagaagc aagttaggga ggaaagggtt tattcggctt acacttccat actgctgttc 99360
atcaccaagg aagtcaggac tggaactcaa gcaggtcagg aagcaggagc tgatgcagag 99420
gccatggagg aatgttcttt actggcttgc ctcacctggc ttgctcagcc tgctttctta 99480
tagaaccaag actaccagcc ctgagatggt cccacccaca aggggccttt cccccttgat 99540
cactaattga gaaaatgcct tacagttgga tctcatggag gcatttcctc aactgaagct 99600
cctttctctg tgataactcc agctgtgtca agttgacaca aaactagcca gtacagttgg 99660
cttccagcgc agacaggaaa atttgaatct tgattcagaa tgagatccgt cctcaaatga 99720
aaagccagaa agtaacagag gaggacactc aatgccctca gtgggcacgc gcacaggttt 99780
gtgtatgtgc acagaagatg gtatactatt accatacttg tttgtttgtt tgtttgtttg 99840
tttgtttgag acatggcttc tctgtatagc tctgggtatg ctggaccagg ctgacctcaa 99900
acttacagag atctgcctgc ctctgcttcc agagtgttgg ggttaaagga gtatgccacc 99960
accccctgtg gacacagatg tattcacaaa ttttcaaatt gcatctgttt gtttggctag 100020
tgcacctggc acagagcgtc ctccacatgg catggatgaa gacttattcc aattggttat 100080
tgatcaaact aattcatgaa aaagacagct gtctttcacc tgcccagaca aggagcaaaa 100140
attcatcctt atcttatgga ttgtgcacct tgcacaatcc atacaaatat tttttatagg 100200
aataaagatt tggttgtaag attcatatat tacagaatga aacagggaga tacagctctg 100260
acaagattca tccttgggga tgctgagatg acccgctgtc ccagctcgct gccacatcct 100320
gcctcacctg atgctgtttc cagagacctg cttccagagc agcgtcaggg gtggctgctg 100380
attcccatga catcagttca tccagccttt cagacagatc caccaagact tcagttaagc 100440
cctgaacatt ctaagcatac agggactgga taacaaatgc gaaaactagc tttcttaact 100500
ctaaccaagt tttcttattt ccctacacct cccaccccct tgaaaaaaat tcatcacccc 100560
aattcagcag gaagtagtta tggagagttg tcatcttgat tccttgggtt taggtgtctg 100620
gctatggtta ttttaacatt attatagata ttttaattat ttaattatta ttaaattata 100680
gatattttaa catattaagg gatactttgg aaatgatcat aattttagac agggaggaaa 100740
ctagagaggt tagacttgga gattctgtct tttttttttt ctttcctttg ctctagcctt 100800
actttcttag gtaaaaggaa gggagctgaa atgaaaatgg ggactagagt aatataggaa 100860
attagagatg tgagatggat tattcaattt actcttaaac aaaacatttt atagttataa 100920
tctttcattg gtagaaatct ttacattttg atgcagaact aaagttatat tttcttacat 100980
tggtacagaa tttatatatc gatacaggtt taaggttttc actggtataa atctttgtat 101040
attgatataa aatttaaaat taattctgtt actcttagac aggcattgtg cctatacaac 101100
tcatttatac aatacaaggc ttagacccag tccttctaat aggtactgtc acaaatggtt 101160
taagatgatt aagtgatgca agttaatggt cagatagtaa actcatgctc atattagatt 101220
ctgatttaat tacaataaag tgttttcaag attatcacgt aggaaataac taagagtaat 101280
caatgtttaa caattcaatt atattacata tagatagatg gtcttcaaaa acatcagagg 101340
tccacaaaat atggcattta aaatcatttc actattaata ggtcttttga ctaggagaca 101400
tgtctgctcc taacagtacc cccatctcac tgcaaagaag gtactgagta tcaatacctc 101460
ccaattggag ttgctttgat tgcgatgagc tagctgctgg taagaaatag cctaatttaa 101520
ttctacagac aattactgtc cagaaaggac aaatggatgc aggacagttg actgctaagc 101580
tctgccaaaa cagagtaagc tagtccttta tatttcctgc ttcatttatg gtctatcaga 101640
tcgttctgga ccagaagtct gaagacaggt gctccaacat tataaggaat attgaggact 101700
gtccaggcag tcagttgttc ctacaaattg tattaagttt tagaagctat gtctttgtgc 101760
tttctacata ttctgataat tttaaattcc ttctcagatc tctgatggaa ttgaaaaata 101820
gttatagtct cataattgaa cttaagttat ttagcactaa agaagatgtt ctagatttga 101880
aaggatggtt ttctgagggt attgcaagtt aaaatcaagc ataattgagg tacagatttg 101940
taaattctgt aagttaagat agataataga gtactttatc taaattgtca gatatgatgt 102000
actggatgtt ctaagtgtat atcatacctt acaatttaca tacttgttat aactgtgttc 102060
aatgtatatt tgggagaaaa gagtttttaa ttggacaaaa ggggggaaat gtagctgtct 102120
aatgctaatt atgtttcctc ataactattt gcatgagagg gtctgcacat agcttctggg 102180
aaccttccca cagttaattc tgattggtaa ataaagttcc cagcagccaa tctctgggga 102240
gaagaaaaag aggtgggtgg ggcttaggtt tcccaggtgt gggacctctg ggaagagaga 102300
aggaagagag actcaatgcc tgaaaggtag tataggacaa agaggcagag ccaccctgta 102360
aaggggccag gagagagtgg cccagatggc tgctcaattg ggccaggaga ggccaagatg 102420
gaacatagaa attggtaagt agtaacttgg aattattggc gggaggtaga gtctagcagt 102480
atggaggcta ggcagatgcc cagctattgt gctgcttaag tcatattaaa atataaaggc 102540
tgtgtgtgag tttttcatta gagatcataa accattgagg taggaagtaa tgctgtgctg 102600
ggatttatta aaacattaat actacacttg tggcaatcac aggacagaca acttgtagga 102660
atggattttc tccttccacc atgtgggtct agggaattga atttaggtag tttacagcct 102720
tggtggcaag catgttcaag ccagccccaa tttaatgatt ttaattaaag ttgttgtcct 102780
ctgaggcaca aaaaaacccc aaagggttca acacaatcag gattcctgct ggcctctcat 102840
ctacagcttg ggccagaagc cttgctctgt tttgcatttg gaatatttta tctcagtctc 102900
tgtaagtcag gcccagggat gggtatagtc agtacacatg aatttggtct gcataactgg 102960
aaatgtgatt atagcttctc agctgttcca aaggagaagc accatcatat cccattctgc 103020
ctttgtgtga aaaactcctc aaaaatacat attagtttgt atctcatata tatgtataca 103080
tatacacatg tatgtatgta tatatgcatg tatgtatgta tatatgcatg tatgtatgta 103140
tatatgcatg tatatatgta tatatgatgt atatataatg tatatatgat gtatatatat 103200
cacagacaca tataatttag gtcacttttt gtccctatgt tttatttctt tcaaaaccta 103260
ctgctgcgcc ttacacagtg ttttgagacc atcttctttc ttatcttttt tttctcacat 103320
aatatatcct aattacaatc tccactcctt ctagtcctgc tagttcctcc cctcctatcc 103380
agagccacct ttctgtctct aattagaaaa caagcttcta ttatatagat tataataaga 103440
caaaacaaca cctaacacaa ctgaatagga caaacaaaaa ggcagaaaga aaagagaagt 103500
cacaagaaat agatccacct gttcacacac tgaggaattc catataaact ctaagctgga 103560
aaccataata taatgtgcga aggaccttta gggtaaagag agagaataaa actgcataaa 103620
taaaataaag taaaaataat aataaaggaa aatccctgac acagcacagt aagacaggga 103680
agctccaaag actctgttga gttcattctc tgctgaccat ctagttctgg acatgtaacc 103740
tacccttaag agtcgtttgt ttccacagca agactgtctt agaggaaact aaattttcat 103800
ttggaaatgg ttatcaactg gaattgcttc tgggttaggc ctaggggctt gtgtctacat 103860
cttctctcag ctctagggtc caatcttgtc cagacctgtg caggtccatg catgctgcct 103920
cagtctctga gttcatatgt gtatctatcg gcccttgttt tcttggtgtg ccccatccct 103980
tcttgctctt gtattttgcc tccttttccc tgagccccaa aggaagggat ctgatggaga 104040
tagcccattt agggcagagt gctttaaggt ctctcatttc ttacaaatat ctgtctgtga 104100
gtctctgtgt tcccatctgc taagggagga agcttctctg atgatggctg acaagacgcc 104160
aatcaatgag catgtcatca ggggtcattt tatcgttaca tttttgtttg cttaaaaata 104220
gtaatatttg gttctaccct aggttcctga actagcttgt ctcaggttct tggttaccca 104280
agcagtgtca ggtttcatct aatggagagg accttaaatc aaatcagata ttagttggtt 104340
actaccataa gatttgtgac accattgccc tagtgtattt tgcaggcagg gcatcattgt 104400
agatcaaaga gtttgtggct gggttggggt ttacctctct cctttggtag tgtgccttcc 104460
cataccaaga actctggtag ataaaggtga aggctctatg taggcaccag ctcaatttct 104520
ccacgttcaa tgggttgtgt aggtgttgtc ttcagcaatt tttagggtca cttatatata 104580
ctatcatatc atctgcaaat aaacacactt tttcttcttt gtttccaatt tgtatcccat 104640
tgattttctt tagatgtctt attgctctag ctagaacttc aagtgctata ttgaaaaggt 104700
atggagagag tagacaacct tgttttgtta ctgcttttta gtggaattgc tttgggtttc 104760
tttccattta agttgatgtg gtcttgctgt aagctacctt tattatgttg atttatccct 104820
aattattcca ggacttttat tatgaaggag tgttgggttt taacaaatgc cttttctgct 104880
tctaatgaga tgacatgtgg ttttgtcttt cagtctgtta atacgatgga ttacatttac 104940
tgattttcat atccctgcat ctctgagatg gtgcctactt gatcacagtg tattatcttt 105000
ttgatgtgct cttggattca tttgcaagta ttttattgac aatttttgca tctatgttct 105060
gtttgaattt ggtctgtagt tttctttcct tgttgagtct ttatgtggtt tgagtatcag 105120
ggtcactgtg acctcataaa acaaattggg cagtgtccct tctatttcta ctttgtagaa 105180
taatttgagg aatattggca ttaactcttc tttgaaagtc tggtagaatt cttcactaaa 105240
accatctggc cctgggatat tttttttttt tttttttttt tttttggtta ggagactttt 105300
aatgactgct tctatttcac taggggctat aggtctcttt aaattactta gctggtcttg 105360
attcaactat cataagtggt atgtatagag aaatctatgt gagctgaaga gatggctcag 105420
cagttaagag tttgctgttc ctctgtaaga cctgaatttg gttcttagaa cccagattgg 105480
gtaactgata gctgtctgca actgcagttc caagagatat aatactctct cttctagaca 105540
ctggacatgg cacacacaca cacacacaaa gttgaatgca aattaaatgg tagataacgg 105600
tatgtgcact tcagagtttg tggtaagtga cagttgattt acttgatgca acacagagtc 105660
gtctggaaag caaatcttgt gcaaggatcg cctaggttag gctggctatg ggcaaggctg 105720
tggggaattg tattagttgg ttacttgtgg taagacctat cctgattatg ggtggcacca 105780
cctcatagtc tcagtcctgg gctgactgaa aaggagtaag ctgagccctg gcatgtaagt 105840
attaattctt ggctctctgc tcttgactat ggatatgatc tgactatctg tgttaagttc 105900
ctgctgtccc cactgcccag gagtgatggc cctagcctgc aactgtgagc cacagaaatc 105960
ccttttctct taagttgctt ttatttcggg gttgggtggt gggcggtgag accgaggttt 106020
tgtttttgtt tttgtttttg tttttgtttt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 106080
gtgtgtgtgt gtgtgtgtgt ccgtgtgtgt gtcctggctt tcctagaact cattctgtag 106140
accaggctga cctcaaattc agagatgggt tcctttgagg caagcaactt ctgaaggcta 106200
ggaaggctca agcacattgg ctcctgggtc cacagtgctc agcatctgta tttcatgaac 106260
agttcctggg tcctctgcca gggctgtaag aagcacggtg tctgcttaat acaactgcag 106320
ccaaagaaga cagaggtgtt ggtgcaaaaa cacagctctc acatcaaagc aggtaatagt 106380
ttattctgaa gccaaatatg agtcccaatg gcctagtaat acagatttaa gttacccagc 106440
attctgtgtc caatgtgcta agatttggta aagtttttat ggaagcagaa gaagtttatt 106500
acaaatccgg gtacttttca aacacattgg tggaggcatc gggtaggtgg atcacagcaa 106560
agcaggaaca actttacttg aggctcagat gctgacagtg tttcacagcc cattggttgg 106620
ccggaaacta agagttcgca cattctacgg aatttaccta atggcacatg gaagggcaat 106680
aaatggctgt ttaggatcct aaagatgccc caagataatt tggctctaga cttgcaacat 106740
tctaacccct ctacatcatt gacattctaa tcagttccgt cagcctttcc agggctgggg 106800
ggtaggggag gaaggcaagg ctatttgagg aatagcttca ctacttgaac accacacatt 106860
cagggctgca aaggacacac aaggctctgg tctgtggtta ctagacctct catcaattca 106920
tgaggttgta gctatttcga actctggacc atcttgtaga ggaatgtgaa tgaggctgaa 106980
tttccgacat gcctttggac agatgttcgt gatgctaact ctagtttttg taagatagtt 107040
attctcttct gtgaagtgat gaagaatttg acacagtttt aaagaatctc cgtctctctg 107100
actccgtctc tgtctcaatc tctctctctc tctcttcaaa ttagaggttt ggtaatttag 107160
gcacagggct gctatatgac tctttgatag cctcacaggc atgtgtactt agtgtgatgc 107220
tcagcacttt gaaggaagga aggagggagg aagggaggga gggaggagag agaaaggtga 107280
aaggagggat gaaggaggga ggaaagagga aaggaggaag caaggaactc agttataggc 107340
caaagagttt tcaggtttat agacacatag atggttgcag ctgtagcctg gcagtctaca 107400
taaaggacac ataaagacat tctcttggcc acaggttgct aaggctgggt aggaagtctg 107460
tagaaggaag ccagaagtca gtaagtcaca gattaaacat tgagcaaagg accacatcat 107520
tagtcactca atgctagtgt ttatttgtct ttctcttttg tttgtataaa tggaagtact 107580
ctctagggtt tctgtttaat taaaaatctt attaaatata agcaatgaaa ctggcttaac 107640
caggaaactg aacattaaac ccgttcacaa aacgtatgat ctgactagga gaaagagaaa 107700
tgtgctaccc acaccaatcc tggttggaca tgtgcctaag ccgaggtcac tactagattc 107760
agtcagtacc cagagaaggt agcaaacagc ctttgccata taactgaatg aagggccagc 107820
ctcatatctg ggtttctaac tgcagaacac atacatgggt gtgtatccca ggtcaggttg 107880
tgggtggcaa ggccttgctg ctgtataggg gtcagggctc ttcttgcata tctgtgttta 107940
taacaagagt tgcttctggg tggcacagac taggggagac agctcctcct tctagtatct 108000
ttgtcaaggg aacacactat aaccttccat ggtggttagc ttaactattt cctgtgggtg 108060
tgtcccttat taaaactata tcctaaatat ggtcctctct taggaggcat cccatttcct 108120
agtcagtcat catacatgat atacaaagag aggtatcagg gcctgggctc catggctgtc 108180
tagatgtttc tcatctgttg tgggggatgg tgcagcatgc cctgagctgc ctgagtcact 108240
gcaggaatga ggaagactca cagggaggag ggaccaattt ccttcttcag tagagtcaga 108300
gagctgcata ggtgagatct gagctgtgca aggagtgggc agggcttaga tgtagaaaat 108360
ttttaatcct gacctggggc ttctaccctg cctttgactc tttagttccc agatagaaga 108420
cacacacagc ctttataatt acaataaacc ttcaacagca caagagctgg gtggatactt 108480
accctctacg ttattagaat ctactttcct attgataact ctgaattatt acttactact 108540
taactatgtt tcatctgggc tgctcttaac tccaattggc cagccctcag ggccatgttt 108600
ttatgattcc caaaccatgg caccttctcc tttgtcttct gtaccttcta gttctccttg 108660
gttctcctct gacccatgag gtcaccccaa acctctaatc cctccagtaa ttggctgtag 108720
agaattttat ttaaccagta gctttaaatc aagggacaag gtttgcagaa cacaagcttg 108780
taaacaggag aagtcttttg taggccaaga cctttggcta tagaatttag cattacaatg 108840
catagcatca gaccaaacct caacacttag aaactcagca agggacaatg tgggcaaaga 108900
cgtggagtga gagccccctc agggacccca tggtcacctg ttccccatta accacaggtc 108960
tttgggattc tgcaaacccc cagcaacccc cagcagctgc tggaagcacc atcccatact 109020
ccatgagtgt gtatccaagc tttgcaattc tgaagtccta tgagacaatg tgagtagtgt 109080
gtcattgtca ggattcatgt atattgtaga cacaagattt aatgaaatct ttctattgtc 109140
aaaagtgttt ctaaaatgtt tggaattaca ttagagcaga aagagctcca atttatgttt 109200
tgctaggtac cttcccaact tagtagcttt atttatttat ttatttattt atttattatt 109260
tttgatcatg tgcaggctcc caaagtgcat gtggaagatc aaaggacaga tttgtggagt 109320
catttctcat attctacctt atgtgggctc cagagctcat acttaagttg ttaggaatgt 109380
gaggaaagtg ctctacccat tgatctatcc tgctgaccct ttagccattt taaatagcaa 109440
ccatttctga cagcatttgg catctgaaga tcaagaattc aggggctcct tagctgtgtg 109500
ggtctggccc caggctctca aaaggcagtg agcacatctt ggccaaggtt atgtcacttg 109560
ctgttgaaag atcaaattct ttgggttcag actccatctt agacaaactt gacttaagta 109620
aattaacagg tcggtaccta gctccagttt ccagattacc caaaacaaaa cctgagctta 109680
gctccagttt ccaggctacc cctaacaaga tctggatctc cagtttattc tcctctaaca 109740
aatccactgt ctagcaccaa tttccaggtt aatccccagc aaatcccaac acctccaggt 109800
tacaaggccg cccctgccta acaaccacca attaggagga aagccaacgt ttggctccca 109860
gcaccagcca attacaccaa aggtcacagt agcaccccaa ttagatgctt gctaggcttg 109920
aaacactcac ccttcacttg tgatttccta taaaaccttg tcccagtgag tgatcaagga 109980
atttttccat ggaaccgtcc tgtgggtcag cagtgaatca agacccacgc tcgagcttgt 110040
gaataaagtc cctggtgtga tagcatcgga tccggctcct tggtggtctt ttggagttca 110100
tgaacatttc agcatgatac tgtttaactg gcatgggcat tcttcttgtg gtgggcatct 110160
gttcttcaaa tggcgcatct ctgtgtgagt gagtgtctct atggcatggt ggttggtcgc 110220
cactgaaatg acttttgtag aagagcaaac agataaaagg ttcttttgtg ccgtagtctc 110280
tgtcaaacca tcacttctgc tgtattttat cggccaccct gagcatcctt gatttgatgc 110340
agaagaggat tatgcaagca aataaatacc agaggatgtg taccactggg aaacaaggca 110400
aggtcacctc tgaattcata ttctgggaag attagagctt tcagaacagg agctgggcac 110460
atgcctgtaa gctccacact cagaaggccg agcagatggt tcacaccagt ctcagttaca 110520
caagtcagtt aaggtcaacc tgggctactt gacaccctgt ccctacaaca accaaatata 110580
cacgcatgcc agagatgata tagtgaacta gacaccctaa aaaaatttca cctttaacgt 110640
attgaaaaat actgagtaga acattttaaa gatttatttt ggtttttaaa tgttatgtct 110700
gtgtatatgt gtctgagtgt atatcgcatg agtgtatatc gcatgtgtct gagtgtatat 110760
cgcatgcatg aaatacccac agaggacaga caatgtcgcc agaactctaa aactggcgtt 110820
acagacacct gtgatccacc acgtgggtgc tgggagccca atcctgatcc tctgcaggag 110880
caacacaagc tcttagtcac tgagccatct ctctagccct aagagtcaac aaataaacac 110940
acacacacac acacacacac acacacacac acacttaaat ctttaaaagc tgccccatta 111000
tactatcagg agaataacag gtaaaaccaa cacaggagga ggtgtggatt gagagactcg 111060
cggagttgca ggctctcctt ctcctgctct agttcccagt agcttactat tcatttaaca 111120
atgtttatgg ccgtttgcta ggcctattcc tcatctaact cctaacttac ttaacctgtt 111180
taaactattc tatgtctgcc acatggctgg ttacttctca gtatcatata tctaatttcc 111240
tcagagtgca ggtggtgaac ctcccagagt ttcagtctgt ctactggaac tcccagtttc 111300
tacttcctgc ctttggcaaa aaacaccatg cggcatattt ggttttaccc cttgacctag 111360
aaaacctcaa gtgtttattt cctggccctt tattttctaa aatgccaata agataggcca 111420
ccagatcttt aatgacaggt gatgcttcga cacagtacct gagagattat ctctacagac 111480
ataagtgctt aagctggggg ctcctctagg cacatccctc aaccaccaag tgacagggaa 111540
gcttggtgag tttctttcac atggcaacaa acaaggcacc tcagctagca agcaggaaag 111600
caggagataa catgtgacgg atgtaggcgt cagagcaaag acccttccag aaactgcctc 111660
aaatctcaat ggatatttct cagtgatagt tcacatcagg cttttttttt ttttatgagt 111720
actatttttc ttggtttatt caataggctg cttcaattta ccttaatgtc cacttatact 111780
tatatataag cttcttttat acaagctcag tggactcact gagaaagcac aactaggaat 111840
gcaaatcaga cagcaatatt aatacagagt tcaccttctc ctttcaatgg aataaataat 111900
gcgtgcattt gtctctttct aaatatttag gcaccaaaag ttttcatggg actctttctt 111960
ttttatttta tttacttatt aggtattttc ttcatttaca tttcaaatgc tatccccaaa 112020
gtcccccata ccctcccccc tcccactccc ctatctaccc actcccactt cttggccctg 112080
gcgttcccct atattggggc atataaagtt tgcaagacca aggggcctct cttcccaatg 112140
atggccgact aggccatctt ctgctacaaa tgcagctaga gacacgagct ctgggggtac 112200
tggttagttc atattgttgt tctacacatc aggcatttct taattctctt tccacatgca 112260
aggagataaa acctttccta cttctacagt agctctgatg gtcagggaaa gtcaggaatt 112320
ataagcagag tctgggttta tatgggcttg cagccacgct cacccagcat gagttacaga 112380
aacctggctg atagtctgtt tggaaatgtg acccagcatg agaagtgttc tctgtctaga 112440
aacaaacggg agtcctgttg aagcacatga tgtctttggt tttgcccctt cgtttagaaa 112500
gcctaaaaag attattatct ggccctttat ttatttttaa ataaatgtca atgttagttg 112560
cagaaatacc tgcatagaag cccccagtta gcctagagtt gaaatacagg aaagatgcat 112620
ttatcaaact accctgtgca gcagaacaaa ctgaattaga gaccggggca ggaggaagct 112680
tggttagaca cagtcttagg cttggttaaa aaaagggggg gggggcgtta tgcattatgt 112740
acagttaact gggtacctga aatagaccag acttgcttct gagcactgag ggcttaatgg 112800
ttaactataa ggagcctagg gaggaagatt ggttcgagaa catagttact cctcaattgt 112860
gaatggagtt ctgcaaacag agaacattaa gaggaacaga aaaggagaat tcttttggaa 112920
taatagctct ctgccacatg tacccaggtg ctctgatccc caaatacatc aaagctgctt 112980
tgtcacccag tctgtgccag aatgggcttg cacaatgcat ctgagcaccg agtgctaata 113040
tgctctcctg agagcagcag tggggagagt ctgagctggt ggcagtgagc tagctgcaga 113100
ttgctctggg ctggtggcag caggacaagt caattagggg agtgattggg agaaaggaag 113160
gcaagaggca cccagagcct ccaggctctt gtttgaaaaa tggaagacac acctggcttt 113220
ttccacattt ccctaggtgc tcgctagggc ctggtcacct gctctcctga ttgactcagc 113280
agggattggg ttgtaaaatt aggggctggg tgatgaggca gcaacttccg agtgcctatt 113340
ctgtgcatgt ctttgtacat ttatcaaggc cctcaaatca ccctcacaga gcagatattg 113400
gccccttgtt ttgcaaatag ggataccgag gtccagagag aggtactaag actacaaagg 113460
gagatgccac ccccaaatcc ttctttcttt atctccaagt aattctagcc aaggaccaca 113520
tgggagggtg ggtgggctca gcccagctct ccttctaaga acaaaaagga cttatgatgt 113580
cccctgggct ccccatttct ctgtgagagt ttttaggctc aacccatgag gcctagacct 113640
tcctgagaat ggacaggcaa tttatggtag ctgaggaaag gaggaaacat tttctttagc 113700
tgtgtgactg accactgatg agtggcacat gtgcctataa actcactggg taacatacac 113760
agaggggcat gaaaaaaaga ggggggctag ttgagaagaa gggaggggat caggagtggg 113820
agggagagaa gaaaggggag cgatgggtga atatgatcaa tatacattgt atacagggat 113880
ggaaatgtca tgataaggcc attattatat ataattgata aatgctttta caaaatcaga 113940
acagaaagat aagctgagga ggaagttcag aatcacaaat aagtaaaata acaacaggga 114000
aaaatctttc tcagaacgtt gctatggaga tagccacatg ctgtgtgagt ggagacctca 114060
ggttttccta ttgggcaaga tgcattgagt agctacagtc agggaaagcc aggaggtctg 114120
aacctcgatg ccagagagcc catgcagagt tgagaacagg aggaaggttc tgaggagccc 114180
ggagggtgga tgtgggtgac aacttcagaa gaagaagggc aggctggaag ccagtatatg 114240
gagacagatg tcattcctgg acctcacggc taccttgctg agctcacttt ctgccagcag 114300
gagaaacatg ccctgaagat gtgaagatgc cagagaccgg tacagaaaag cgagaggagc 114360
gttgttgtgg ttggttgtat gtgctgactt gatcaggctc cagggtgctc aggtatttag 114420
aaaagcattt gtaatggctg tgtctgcaag ggtgtctttt gatgtgtgct accgtgacct 114480
ggcagagtga agtatacatt gctctcccca gccctggtgg acctcatcca acccattgga 114540
ggcctgtgtt gtgcaaaatc gcagaggtag gaaaatgtct tccctctgcc tatttttgag 114600
cgtgagcgtg aatgctcttg cctgtggagt aagacataga ctggacctta cctgtgttag 114660
acctccatgc ttcttggatt aggatttgga ctagaattta tcagctgttc tgggtttgct 114720
gttgtgaccc acaggtcatc acactcctca gcctctgtag cactgtgaga ccattagtta 114780
taagaactcc tggagttgga gagatggctc agaagtgaag aatgcttcct gctctttcag 114840
agaactggag gtcagctccc agcagctgta tcaccatcac gtgacttaca aacacctgta 114900
cctccggttc caagggatca agtgcccttt cttgcctctg tgggcaccca gacatgtgca 114960
taaacgtaca cagatataca cataaataaa gtaaaataaa ataacatgaa tcttaaagga 115020
agaaacccag tcaatcatca cccatcctgc ctgcatcctc ttggttctct ttttctctgg 115080
gtcaaatgga ttgccccata caagcatctt cttgctgcct tctctacagg ctggggctaa 115140
acagggaagt tatgggtggg gacaactttc agacagatca agaaggagga aggagcgact 115200
catgattttc aaagacaaca caaatgttgg cagtttgggg atgtaaccga tgagggcagt 115260
ggactcaggg gcagacccgt gcgcatgcgc ccacgtgttg ccatggcacc aacaccatgc 115320
gctcaatggg atctagccac acttacgtta atgctctggt actacagagt tggaactttt 115380
agtaagtttg agcgaggagt aatatatcag tggtgatgag catgcagggt taggtccctt 115440
agagaaatgg tgactagggt gggaagtgac acagctgttg ccatatcaag gctagagagt 115500
tgctccaccg aatagccata agtcctagta tcagcctcag agttcaggaa ctctgctttt 115560
cttgtttgtt tgtttgtttg tttgttttct tcagacgatt ctgtgaaggg aagatggaaa 115620
gtgttaatta tataaactga agacgtttcc ctgtgaagta aggccagccc atacccagcc 115680
ttaggctaag tttcacttgc cctttcgcaa cacaaacctt tgtccctaga tctgactaag 115740
aggttaagca atgtgaatac cggtggccag gcccttcctc tccccagaag agagaagagg 115800
tccccgaggc agcagatgtg agtcaagtgc cttgtggtag aggaggccac tggagtagac 115860
ctgggaaaag gttctgacac tgtttatgac tgttgggctg ggcttgatca gaccaagcac 115920
caaacgcaga gctatgtatg cgcagctctg accttcctcc agggaggatt tcaggatggg 115980
tgctcatgag gctccactcc tctatgagta tcggtaggca ggattaatgg ttgccccaga 116040
aaagtaatgt tttcttcagt ggtgtagcta ctgataagtt gcccatgtca ttgtaaataa 116100
cccctcactc aggctcttgt gattaattca ctggggcaca tgacatcaat gacatcacac 116160
atacacacac acacacacac acacacacag agagagagag agagagagag agagagagag 116220
aataataaaa aaataaaaat ttaaaaatca tctagtcttt gttaataagg ataatatact 116280
tggtggtata cttaaaattg gtggcaaaaa atcatgcccg taagtaagca ctgtctgagg 116340
gcttgcgaaa gtttctaaac ctgtagttac aggcatcctc aacaaaaggc atggcaagtc 116400
attgacatta gtgtcaccca ggcacacagc caactcaggt gggaattgtt ggctctgtaa 116460
ggacaggcaa aggaaaaggt cacactcaaa tggctcatct ctgtcatcct tagtagaaaa 116520
aattgaaaat gatattagtc aagaaaggac taaataagat gatatgccta atattcaggg 116580
agaccaggat aatgtttcaa atgccctgga ataactggct ctgtgtgtgt gtgtgtgtgt 116640
gtgtgtgcgt gcacgcgcgc acgcacatgt gagtgcacag atttatgtct gaatggtctt 116700
cagaaattag gtgatattcc acaggaagga ttttccatcc tatcaagaac ctaagaatat 116760
ttcaaggaac cagatcacta tttagggaag agggaaggtc gtgtattata ttagccagat 116820
atacttcact cagatatgat tttggattac acatggtggt gcacaccttt aatcccagta 116880
cttgagaagc agaggcagga caggagacac ccagggccaa cgagacccac atgaatgcac 116940
accccctcat gtgtcagtga gagctctcgc acactctccc tctcataatg agaaatgaga 117000
aaaggagaaa gataaaatat ctgctattcc ttgtattagt caaaaaactt cctgcgtttg 117060
aggatagctt cgtgtgtact tagatattta gaaagtctca ggtaaaccag tgcttaatag 117120
tttgtctcaa acaaacaaac aagcaaacat gatttgaacc aatggcattg ggtaggaagg 117180
ctttgggctt cagataacaa agctgaagga aggtctgctc tagccacagc tgaacgtcca 117240
gtcctcttct ctaacaggaa gtctgcagga agttgctctc caagtccacg cagcacttcc 117300
agggcgtaag cagctcagag tctctgaact tgcctgcttg tttcgctgct tcctcttcca 117360
ctccaggtgg gaaccacggc tttgagcgac agagtctcat atgtcagctt cttgaggcag 117420
gagagagaga gtgataatgc tagaggattg tcttccccct tccccccccc ccccgcccca 117480
ctctgacagg aagagccttc gccaccgtga caacctgcct gcgatcatct taacttagtg 117540
gatagaccct cagacgagtc actggctgac aaatatagac acccatgatt ggcttacagc 117600
atagtgttca ttgcttcctt tcttttccat ctgcagtcca gtggggacca ttaaaactaa 117660
gtcaaaggga aaactattca tggtttttta aaattttttt aaattttaaa gagagaaata 117720
tgaagggcta gggagatggc tcgggggtca cgtgtgtgtt gtacaagcat gaagattaga 117780
gtattatctt cagcaagaag gtaaaaaacc tggatgtggc aagacctgta atcttggcac 117840
tgggaggtag agaccgaagg atcctgaggc ttcctggtca atcagcatag agcttcagat 117900
actgtgagaa aaccaaatgg cagagaggga taaaagaaga tccccggtgc tagcctcatg 117960
gacatgcaca caagcatgca agaatgcaca cgcgcgcgcg cgcacacaca cacacacaca 118020
cacacacaca cacacacaat cataatgaga gtagagaaaa gtagaaagaa agacagttta 118080
ttattccttg tattggtgaa accctccact aaggggcaaa agctattgta caccatgaac 118140
acctgcaggc tcaacccttg ggtgcagagg gagaagactg cacaatgaat tccacaccaa 118200
ccatggagaa acataaatta acgaacaaat aggaaagcaa gcaaaaaaaa aaaaactaga 118260
ctggaaggag ggattctggg tcatggaaat atcattcgcc attgatgaat tttattttta 118320
tgttcatttt tcagctccat ccctactcct taatgtcgct gccatgttcc tgtgctatgg 118380
taaatctctt gatttaaacc aaaagctttc cttacttcct ttcagaattt cacttacgtt 118440
actctctctc ctctccctca cttacaatga ataatcttgg aagaaaacat gtctgcatag 118500
aaaaggactt tctggttagt tcataatgtt gttccaccta tagggttgca gatccattta 118560
gctccttggg tattttctct agctcctcca ttgggggccc tgtgatccat ccaatagctg 118620
actgtgagca tccacttctg tgtttgctag gccccggcat agtctcacta gagacagcta 118680
tatctgggtc ctatcagcac aatcttgcta gtgtatgcaa tggtgtcagc gttcggaagc 118740
cgattatggg atggatccct ggatacatca ctggaaagag aggcccattg gacttgcaaa 118800
cttgatatgc cccaggacag gggaacgcca gggccaaaaa gtgggaatgg gtgagtaggg 118860
gagtgggggt gagggtatgg gggacttttg ggatagcatt ggaaatgtaa ttgaagaaaa 118920
tacgtaataa aaaaatatta aaaaaaaaaa aagaaaagga ctttctacct tactggcaac 118980
tgtaggctct taggcgaggg ctctcgcctc agtcatacgc gtcttcctct ctgtaaagtg 119040
agctggctaa attagacaca tccgaaggtc acatagcccc agttctgaaa cttgatggtt 119100
ctaaagtctg cggggacaag cacatgaccc ttctccaacc tctggtatca ggttctgttc 119160
ccactcgttt tattcattat ctgctctgtc ccctacttaa cccagactta tttgtgcagt 119220
ctctgaatga gcaagccagg cttttttttt ttggatgata ttattagatg ctcctgaata 119280
ttctccaagt gctttaaatg aaaactctgg acagtacagc cagacttccc aagttgccaa 119340
cttgtcccag gccttagaag tcacctaatt acattgaatt ctgcctggtg gagatgaaga 119400
cagaaagcct gtcactaatg gtgcatgtgt tgagggtggt gaccactcca tctttattgc 119460
cagctatgct aaagcccttg ctgcatcaga aggagtgtga gcttgtaaag ttccgagtct 119520
gcagcatgat cttccattct ctaagcggta aggcttaatg tgtgtgtgat gctgaccagt 119580
gaaggaagat tctagcaata ttctgaaagt gatagataag aaatcaatac taaaatccat 119640
ggctgagaat ccgtctttgg ttaatgggta gccacagaag gtgggagaga gatttctgga 119700
tacttcaagg agcagaagaa taagatcagc cagaggggct gctctgagca tcgattgctg 119760
ctgctgctgc tgcccctgcc gccgccgccg ccgcctttgt cgtctttgtg tattttgtgg 119820
cgctaaaaga atagcaagca ccaggcagct tctaatgaac aaatgcttgt gattctggag 119880
gccaaatcca aaactgagat actgacatct ggaggggcct tctggctgtg tctaatatcg 119940
tagacctcat gtggcagaac cacaaatgga gagagaaaac taaaagggtc cacactcact 120000
cttcactagg aatccactcc tgcaatggtg gtcgtaatcc cctcacccca ttctttcagc 120060
tgaatctttt ttttttttca tcaggttctg ccgcccaacg ctattgcgta gggagtactt 120120
ctagcacatg cttatgggag tgtgttatca tcacaagagt tggtaacttt caaggagaca 120180
gtgtgaggga aggctgtaga aatatttaag aggcaacaga cttggtcagt caatgaagcc 120240
agaactctaa ggggaagtgt gatgctcact aaaggaaaca taaaggactc cacccctacc 120300
ccccaccccc gggtgaacag aactcttctg tgctgtccca gccttgcaca acagcaacac 120360
tgatacccta ctcccacagt gacagaaaag gacttgggac tcctatgaag gacgagggac 120420
ttgactagag ctcactacct tgacctttca ctgttagaag tggcataagg tgaagagcta 120480
cagcttaggg gctggagtga tggccacttg ctgttcttcc agaggaccca agttcagttc 120540
ccagcaccca catcaggcag ctcgcaacaa ttacccatga ttgctaccat tgatgctgat 120600
gccttcttcc aacttctgag ggtacctgca ttcttgttct ctctctctct ctcatctgta 120660
aaaatcatat taagaaaata tatatttggg tttaaaatca aaatggaaga tacaggttat 120720
agagatatat ttagcaaagg aaccaagaac acttgatttc tgtgccagag agtcacactt 120780
tcctcaaaga gctcccaagg agaaacaata aaaataaata cagctcttac tttgcactag 120840
atgctgttag gagcacttta actccattag ctgattttgt tcttataaca gatgccaggg 120900
caagagaaag ctgtatcagt cacttgagaa ttgaagttga tttcatggca ggcggtggga 120960
cagagagagg aaagtgggct ggtccttaca aagcacagat gcagaaaagt tacactggga 121020
gacaaaaatg agaagagatg cagagtagcc tggctagctg gctgggttca ttcatttact 121080
cattttacct ttattgagat ggttagaggg taagtctgtg ctcaccatag tgacaaactt 121140
ttaaatgatg cttgtgcttc agccccctcc agtatcacct cagtcttatc attcgaacac 121200
ttggtcctga cgggctttgc tttttgacct tgtacatttt tttaaaaagc gatttttatt 121260
tctttttata ttatgcctgt gtgatgtaat tgtcccacat gagtgccacg gccacgggag 121320
cctgaagaga gtgtggcatc ttctggaact agagttacag atttgtgagc cctgtgtggg 121380
tgctagaaac caaatccagg tcttctgcaa gagcagcaag cactcgtagc tgatgagcta 121440
tctctgtagc ttccggataa ttattttgat gacaaatgtc tacctgagcc tccatttata 121500
acattgcaat cattcctaga gatgtgcact agtagatttg tacaatagag tgcaaatcag 121560
catatttcat gaagacttaa aagcttaagg tccttcagcc atttggaatg ggcaaactgc 121620
tgggacattt ataccatgca gtgttgtata gcagagaaaa tgggtgaatc atcattacat 121680
gtgagtgaag ggctggagag atggttcagt ggttaagaac atgtactgct cttacaggag 121740
cttagtaccc agtaccatgt caggcagctc acaactgcct gcagttctag ctccaggcgg 121800
gaatcgaata cctctggcct ctgagagcag gcatatacca ccatacacat atatgcataa 121860
tttaaaatga aaataagttt tgaaaacaat taaaaaataa caggatgaat aaagactgaa 121920
caacatgttt gagtctatgc cggggcctag caaacacaga agtggatgct cacagtcagc 121980
tattggatgg atcacagggc ccccaatgga ggagctagag aaagtaccca aggagctaaa 122040
gggagctgca accctatagg tggaacaaca atatgaacta accagtaacc cggagctctt 122100
gtctctagct gcatatgtat caaaagatgg cctagtcagc catcagtgga aagagaggcc 122160
cattggactt gcaaacttta tatgccccag tacaggggaa tgccaggacc aaaaaggggg 122220
agtgggtggg taggggagtg ggggggtgtg tatggggact tttgggatag cattggaaat 122280
gtaaatgagg aaaataccta ataaaaatat taaaaaagaa aaaaaaaaga ctgaacaaca 122340
aaaacaaacc agaagttcca ggagaatatt ggctccgcac tttatctttt ttaaggtcca 122400
aatgccaaaa caggtattta ggtagttgtt gtctaagcca tttgttgccg atttaagtaa 122460
aagtccatcc attttctgtg cctgctaaaa ttgatacttt taaagcaaga aaatgaaaca 122520
ggaggaaatt caaggtggag gatgtctcgg tggagcagga gggcgtgaag agagagcaca 122580
cggaagtgag gctgttgacc gtgttctcac tgtgctgggc agttgagaca tagatactta 122640
tttggaaaag aattaaactc gagggactca gtggaatgga aaaagtcagc tatgggtgga 122700
acaccagacc atttcatgaa ctgggacttg taaatgttct cattctggca cctgctgagc 122760
tcctagtgac ataagagacc taagctccag atttattccg aattaacaaa ttgagccaga 122820
tcctcagatc tcgtggaaga acaagcaggt gctctcgact aatgagccac ctctccagtc 122880
ccaaggtata gagctttgat ctccattttt ctttatgtac aaatatttcc ctaggcatta 122940
aaggtgtaat ttccataatc tattcagtgt atcaggctgt ggtcatactg aataagaggt 123000
tttcttcaca gaagcatcct gtacattaaa tagaaagatc aattttaaat gacacctgag 123060
cttactccag tgtctctgct aatttgttga acttttcctt cataatctct ttaaattaat 123120
tattaactag cccaaagcag ggtggacttg ggcattatag agtacctggt caatttagaa 123180
atcgtttagt ccaagtcatt agaggattat tacccttttt tttttcttca gccagatggg 123240
ggatgtcata aatgtacaca attagggttc tttaaattag gcttatggct tggatgtgaa 123300
atgtccccta gaagctcaca tgcttgatta cttggtcccc agctggtagc actctttcag 123360
gaggttggac agacacacag tctcattcat agttggtggg gcatagggat gaaacttgag 123420
ggttacggat cgcctctgat tctgtcctgg ttgctctgtt tccagatcca gtcacatgtg 123480
agcaagctat ctcacactcc cgttgtcata acggactggt tctgtttcca tgtgtttctc 123540
atggcggtga tcgactttat cctctgaacc tcgtgcaaac cctccatgac tcaagttggt 123600
cctcctatta ggtgtttgcc ctctgtcatg agaagagtga cacccatagt aggctccttt 123660
ccatccatct cgcatgtgcc ccacggtcag gttctgttgg tctaaggctg accatcaact 123720
gctgctgaac atatatatat agttgagaaa cttttccagt catactttcc aagaaataaa 123780
taggagcttg agtgtggtga gctgtagctc tcagctggcc actgatgtaa ttattaatca 123840
ctgcatgcaa ttaattggga cctttcttag acatgtttgc cactgatccc tgtttccagg 123900
gagtttcaca aatgttccca ccccagcctc gtacctctat ttgttctttt gtaactttat 123960
aaaaatttta atctatacaa gtttgcaatg cattgatcat atctattccc accctcacct 124020
tcctggttat ccgagattct ccccaccata tccctttgaa gtgtcagatc ttcctcttct 124080
gctctttata acctactaag tggtgttcat atgggcacag gtgtaggaac attcaccaca 124140
gcatgagcaa cctgtaagag accacattcc tgaagaaaac tcccctttct ccccagggga 124200
catcaacggc caataactct cagttatgga tggggtacct tccgtttatc ctggaatgtt 124260
gactggatga atctgtgtaa gcagccactg ctgctgtgag ttcgttaagt gtaatggcct 124320
catgttgaag ttaagccctg gatcttcctc caagctccgt gctcccggaa ataaggctca 124380
gactcaaaat atatttacaa ataccttggc catgtaacta ggctcttctc tgactagcta 124440
taacttgaaa taaccattga ttctagccta cattctccca tgtgattggc gatatgagct 124500
caggtaccag gcatctgtct tgtcacatct tttcagtgac tctctctgcc tccttctctc 124560
ccagaattct ttctcctccc acggttcacc ttctatttcc tgcctaagcc atagcccatg 124620
ggctttttag ctgacaggtg atgcattcat acagtagacg agatgttctg tttatagcct 124680
tgccataccc agaagacact gtgtcacaac agtcactccc catcctgacc tgcagccctt 124740
atgacctttt ggccctctct ttcacagtgt tccctggggg gtggtaatgg tggtggtatg 124800
catatatgtc ctgttttgag agcaccgcat ggtcattcca catttgttct taagtggaag 124860
aaagcatgat gcaaaacaga aggagtgagc tagactttaa ctggatttag gggactttat 124920
aagagaaagt aaaaacgtcc tcaagaattc attaaaaatg aagagcatct cccccatgct 124980
catttctgtt cattacaaac gactcaacta ttacatgcaa atattactct aggaaaatag 125040
ccacccactg atatgggtgt ggagatctcc aaagacaaga ggaagttgaa aagggctcag 125100
atggctcctc caatgtggcc ttccagctta tgacaagaga aacacaattg ctggtccagg 125160
gacagatgtc tgctgcactt gctttgttcc tggctctccc tctgacccaa tttacagccc 125220
ccctgcagct gtctcctgca tactttccca cgtgaagtta tttatctttc ttaacagtca 125280
actcgattta ttccaagaga atgctcccct cccccagctc tgctggtaat ctattcctgc 125340
actaaattgc cattgtaatc aaaattccta gaatagttta agttggcctt ctgcagctgc 125400
agtcacctct gtcaaagccc tggccaagcc tcctcagtgc cctggagtga gtgtcattcc 125460
acattgctgg aaaccacacc ccatctggct cttcccgcct ttccaggctc cttttgctgt 125520
gtccttttat catctctact gaaccacttt cctgacaaag ctccaacacg gttcctcctc 125580
tagagctacc gacctcttca actcctatgt ggtcattttt ttttctgtcc ttggccattt 125640
cttaacccat ttttttagga catcctcttc tctccttgaa acttggtcag atctgccacc 125700
atatgtacca cttactcaat attttgatcc cggagctcag ttccgtggtg gctaattttg 125760
tcaacagaca acatctggaa tcatctaaaa ctcaagttgc tgggcacttc tgtgaggcag 125820
ttttttaaaa tcagattatt tgaagcagga agacacatcc gacatccggg ccccactttc 125880
tgatggcagc ccagataaca tgacgtggaa gaaggacact tggctttttt tttttttttt 125940
ttttgcctgc ttgccccact gtgtctggca tctctcctgt tgctcaggca ttccttcact 126000
attcagaatc ccaacaaaga tagaaaacca tctgctctcc aggaatcctc caggatccca 126060
gagctaggtg aggactgctg agacacccag ccttgtggac tgaacagctg ccagtttaga 126120
tattggtctt tccatcatga gactgccatt gttgaactac tcggaccata tcctgtaagc 126180
cagccttata aatgcataca cacacacaca cacatgcaca cacacacatg cacacacaca 126240
cacacacaca cactcacact cacacatgca cgcacgcaca cacacacatg cacacacact 126300
cacaaatgca cgcacgcaca cacacgcaca cacacacaca cacatacaca cattcactct 126360
cagttctgtt ccttcagaga agcctgacta aatcaggttc ccagcaccta tgatgggcag 126420
ttcacaatgg cctgctaatc tagctctggg agatctcctt gcttcttctc atctctgcag 126480
gcactgtact cattgtgcac acataaatac taatactaat aataatagta atgaaaatta 126540
taaattcata tgcataccag tttttattag ttggcaacag attgcataac cacaacacca 126600
cttcacaacc agaaaattga cagactatac tagtcatatc caggtttcat agttttgccc 126660
tgtgcttaga catgcatatt ttcagctatt cattgattgc ttgccatact agaaactgac 126720
ctacacaggc taagccagtg ctctaccgct gagatgtatc cccagccttc tggttccatc 126780
tgacttaagt tgcccaaggt agcgttgatc ccaatctgta acacaggcat acctgaaact 126840
tgcaatcctt ctgcctctgt cacctgcgta gttgagattt taggccggtg ccactctgtc 126900
tgtaactttg ttatgtggag agactcgtgt gcctctctat gagatacact tgggaagaaa 126960
gaacctgccg gttaagggat ggcctccatc aggttgccta tggggatgtg tgtggtacct 127020
tctctgtcca gtttactacg gggagcatct tccctaggca ggtcgcttag gttgtctaag 127080
aaagctagct gaacacggag caaaccacta aagggcatcc ctctgtggtt tctgctttaa 127140
ggtcctgctt tcaatctgtc tcctgtcaga tgaaacaaac cctttcctct ccaaattgcg 127200
tttggtaatg gtgtttatca tagaaaaaga aaaccgagaa aaagaaaacc accatagtca 127260
aacttagact cgtcccatca gtggcctctt gtgatacctt ttagaaccaa ctgccacctg 127320
tcccttctcc cgacctgtga ccagcaataa tatgtctcca gatttatact ttgattaatt 127380
ttaagaatgt tgcataaatt ttatcaaaca ccatacggaa gtctgaaatt tccctcccca 127440
gcatgattct cttgatatcc acctgagttg ttgtgtagac cgacactgtt ctcattgcta 127500
ttggtgagta gtatttctga atgtggactt ggtagtttgt ctaattgctc gcttgttgtg 127560
agatgcttgg gttatttcta gttattgaaa atcaacatat atgaaaatgc atatgtagat 127620
tttgtgcact ttcacttctc ttggataaat gccttaggaa aatgttttct gggtcatatg 127680
gcaggcatat gtttgatttc ctagagacat caatgcagtt tttagactga ttgtcccatt 127740
ttacattctc agtagctgcg tatgagtctg acatccttgc cagtgtttgt tgatgtcctt 127800
aaattttttg aaccattctg atagtagggt aggatctcta ttttatttat atatgtgagt 127860
atgtgtttgt gtgtgagcat gcgcatttgt gcatgtatgt gtgtatgtgt gtgtgtgtgt 127920
gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gcatgtgtgt gtggaagacc atcctcaccc 127980
ttggagctgg agttataggc aattgcgaac cacatgagat gggaagtgaa ctcaagtcct 128040
ctggcagagt cctctgtgcc cctaaccact gagtgacccc tcaactcctt agtgtatcat 128100
actgtatgtt tactgagtgt ttctatgatg gcttatgctg ttgatcctct tttcatatac 128160
tactttgtca tctttatagc ctctttagtg gcagatctgt cttttctaag tttcctagtc 128220
taatatttta atcactgagt tttgacggtt ctttatatgt cttagatagt gccaacctcc 128280
actctgttta gatgagcaga aggtctatgg ggttaaaagg ctttttcagt catttagcaa 128340
ccgagaaagg aaagatccaa gtctgcccct gtctttatgc agtctttacc atggctcatc 128400
tcatatgtag tgtcttccca actcatcaag ctacattcat cttagcatac atagtctccc 128460
aaaccaaaaa cccataacca gggtatacat ccttttggtg gggaattgtc tgaagtttgt 128520
cttctaaagt gtccagcctg tgttagtcat tgtatcgccc tatatagtca acaggggtgg 128580
ggatggaaca caacacctaa gtatcccttt agccccgaag agccttcagt tgtcactcct 128640
catcaaaact atttaactag agtcatctca ttcaaattca agtccccttg ccagattaaa 128700
atatagctga tgagtagtta tcatgaaggt aaagaagcca gtcacacggc tagggagatg 128760
gtcaatgggt aaagtgcttg acttgtaaac cctaggaccc aaattcatgt tcccagcaac 128820
cacataaagt caaacgtggc atcttgtttc tgcaagccga ggtgtgaagg gtgaagaagt 128880
gaatcccagg gacttcgggt gggtcaatct agttgaagcg atgagttcca agtttagtga 128940
gaaacaacgt caaaaaataa ggaagaaaga aattgaggaa gacattgtga tatcatcctc 129000
tttcgtgtac atgcacatgg gtaggtaagc acgcaccact cacacacaca cacacacaca 129060
cacacacaca cacacacaca tcaattcttc atagctctaa gtggattctt tttgtcaaag 129120
aatcagctga agcttaatgg agattgcata cctgagctct tgtcttctac agggattgta 129180
agagcaatgc ccagatgact cttatgtaca cagctgtccc agagtctgtt ttctaatcac 129240
tcagcctgtg aaaactggtg ccatccatga cttgaacagg ctggtggtct tgggagccag 129300
atcactttcc cagtgggcac tgaggagctc cacctgccac cagatagcag agtactgatt 129360
aggccttgaa ccagaaatga ccagaaaagc atgttataga tgagaatagt acagtggatg 129420
tcatgttcta ggtgtctgag aaatatggag gaaaatgacc ctaatcataa agaaattata 129480
gggtagatat taagcacgcc taaattatta accagacaat aagaggacat gagagattaa 129540
ttgaaggtta atagctcatt gtgaaaggca ggggcctctc tggtagctta taaagatgct 129600
cttggctttt gcaacctgag gcctgagaaa ttgtggccta tgacttaata gtaagaatgg 129660
tggaacaaca atgaagggtt aagacctgaa gtgaggccat gtcataagtt gttgggccat 129720
tgtcctcacc caggttagga aacaatggaa tttgacacat atggcaggag tggattatgt 129780
caaaaacaat aaaactgaat tgaattaact gtattggatc tagagttgtt tttttttttt 129840
tttttttttt aaattctgtg ctgtaagctt ccagaaaagg catactcctt cctgttaaac 129900
accagtgctc ttctgatgta tcaggactgt attagttacc tctctgtgac tgtgagaaaa 129960
caccatgaca aaggcaattt gtagaaggac gggttttact gggttatagt tccagagaga 130020
taagagttca ttatggcaaa aagagaaggc tggagatagg tatgggagct gagcaggaag 130080
cgcaaaggcc aatggcaaac atgaagcaga gagaacaaat tggaagttgg gtaaagctca 130140
atgcttgttg ttagtgatgc acttcctcca ggaaagttat agccccacac tcccatcgcc 130200
tctccaaaca attctgccaa caggggacca tgtgttcaaa tgcctgtggg agatagttca 130260
cattcaaact accacaaaaa ccatacagtg ctccatgagt taggaaaaca tgcctgcttt 130320
accagattct ctcctggtca ccaagctaaa ccctaaggat atatcaccac aacctggcag 130380
aggactgagc ttggtctggt aatggaagaa ggtataaacc aaaaggaaca tcaggtccta 130440
gccattacca taagtgggac tggattgtgt aagttttgcc tcaaaggtgg cattattcta 130500
agttagatga tggaggatct gtttcttgag gcagggtctc cttggataca ggagttacca 130560
tctatcaaga taggataaag ctgtggctgg catgaataga atcatgatag atgatttaaa 130620
gcctatgtgg gggatggaag cagcctcccc taaagtaaaa gtggaaatgc attattgtca 130680
ttgctatgga tgctttctgg gcaataaaag acagtgggat atgacataca gctagaagtc 130740
ttatttaata atttctatta tgatgctata atgcaaagca tggagatacg gacagatacg 130800
atgagtactg gtataattaa gaaattcagc agtaaatagc tcctgaagtc atttctaatc 130860
agagatgtca ttgtggagat tgtggagatt gtggattgtg acacagatag gaagatccca 130920
aattaacagc cgcaggggtt ccatttcaaa cttagatgcc aggtgacagc atttaccaaa 130980
acagaaggtc aagtgcaaaa gaacaatcag gagatctgac tccaagataa caatggcaat 131040
tgtcaacaca gcttcctagc gttggggaga aaagagatgt caagagacaa taaaaccatt 131100
gcacgcacca gagcaagagg agccaagagt gtatgagcaa gatcctagag acaaggtttc 131160
tccacagtgt gttctgtcac ccaggttcag agctggccca gttttcaaac acagaaccca 131220
acgatgaagt gatcaggtgt cctggaaaaa aaaaaagatt tcttcaaaac catggtgact 131280
taacaggtaa caattccctg acacttccct gaagcaatct tcaatcacca actcagttag 131340
ccataagtta tgggaatgtt tggttccaaa catgtcaacc tgacacagga tcatacacag 131400
attcaaagta tcaacatgaa ccttctgtta cactgggagc acacctggcc atgaatggaa 131460
gctcagaaca gtttcaggat tacaatgtgt ccacagagta ggtaggctca accagtgatc 131520
ctctctcctg tcccagaatg taacattgaa gaagtgcact tggcattggg cccagcttgg 131580
gttcctttac ctgtggatga aacttaatga gggaaacatt aataacatta ttaacattaa 131640
taacataatt aaaacataat gaggggttgg acagaagcac caatgagaac cctgttgctc 131700
aaatctgccc cttacaaagg tataaaatgt gtgttctttc tttgttctgg gtctctcctc 131760
tggcctgcgt gctgagaggg gagtccccaa catgttggat caataaaaat ccaataaggc 131820
cacactccta atagtgccac tccctagccc aagcatatag aaatcatcac attccagtct 131880
ctgaacccca gaggcttgct caaacatatg ggacataact aaacctaaca taatgcaaag 131940
ttcatttagt ccaacttcca aagtcctcat agtctgtggc ggtctcaaca atgttttaac 132000
ttaatctttt aagaccaaag ttcaaggtct ctactgagat ttactcaatc acttaactgt 132060
aatctccaaa gcaagacagg aaaccaaatg ggtaaactcc aaactttgga tcttcatgtc 132120
tgatgtcaaa actctcttca gatctccaac ctctttttta tctttgttga ctgcaacaaa 132180
cttctttctc ttgggctggt tccactccct gttagcagat ttcctcagca gatagttcat 132240
ggctctggca tctcaaacat cttggggtct ccaaggaaaa ttcaatgtta cagcttcttg 132300
tttcaatgtc tgggatccac acataatctt ctgggattct ccaaagggct ggtgtcactt 132360
ctccagcact gccctcggtg gcattctaag ttcagagtga tccactccac tgttgctgct 132420
gttcttggtg atcatcccat ggtactgtgt tgtgtctgct cttgaccagc aagaaagaca 132480
caacggccag attcttctca acagccttta ttgcaggaat gcctcaatgc tgctacaggg 132540
acctagggaa cccagggagg tctgcttata tactctccag cacagggaaa ggcttcatgg 132600
ccccctggga ttggtcagtc tgccggcacc taatttgcat gcacccgctc cggaggggtt 132660
ggcgccagac tcggacttac atctgcgctg atgttgttta tgacaatggc acacctggtg 132720
cccagagcca tcttagagtt ggcttcctac agtactggta tctccaatac tctggggcct 132780
tctactgcaa cgaggcttca ccaataacct ctcataggtt ctctccatgg tgccaagcct 132840
caacttcttt tcatgacccc ttcagtcctg ggctgtcaag tgcaactgag gctgcatctt 132900
caccaatggc cttccatggc ctctcagagt gccaagcctc agctgctctt tatgttccct 132960
tcatcccttc aaaaccagta acacctgagt gatggggatg gatgtagatg aggtgaaacc 133020
cagaacacct ctcattccct gcaagggaag acccatgcct gtagccagaa atgttaggat 133080
tagagcaaaa cccttagtag aaactgctgt gattctcatt tggaagacca tggactgatc 133140
tgtcagcagt gttattggag gtagcctttt tctttctcca ttgtgaagtt gatggtcctt 133200
gggcagactt caagaaaggg tctgaggaga cagacccagg aagagtgtag caataacatt 133260
tgatttgcga ttaagaaggc tggagtcata attagcccta aatgggacaa ctctatcacc 133320
ctctccaatg ctcagggaag aggagacaga aagaatgtaa aagccattct gggcttgaca 133380
tagctgttgt cttcatgtgg tgacctgcac tagagctgca ggcgactggg cattcatcaa 133440
gtgtgtggga gggtcccctg aggccccacc cctcccttca ggactaacag aagttagtgc 133500
ttgccaaggg agtagctatc atcctctgca gtgacacgga agctgacaag ttacccatgc 133560
tccaggaaat aaactcccac ccacgctcag gcaggcgact taccttagac tgagtaagtc 133620
acacacaaaa gaagacatga aagaaggagg ggctcttcgt tgagactaag ggtttcaagt 133680
gggagaaaga gaaggataag actattaaaa ttcattacat acaggtatgg aactgccaaa 133740
gaagaaaatg atgaagagca gcagctgccg ccaccgggag tgagtcagag gtggcctgca 133800
agcctgcagg aacctggccc tcaccaacag aaaaggcgga ggacagacac ctgacaagag 133860
tgttctcttc cctccactaa gtgtctttta cagtttacat gttgatttgg gagactgtta 133920
attctgggat atgcgggggg tggggtgggg ggaacaactc caacattctg gaccaaattt 133980
aaagcaacct ttattaaata ttagatattg accaagggat ggaccttagt tgggaccatt 134040
tcacagaact tcccacctga gaatggcctg agccatgggt tgcaggggca aagggcaaac 134100
ctataggcca ctgtactttc ccatgatgct ttgctgtttc ctaagaacta taattcccag 134160
cattgcagga agttactggg tttctgggca ggtaaggctt acaggttaat tttgggcatt 134220
ataagacaaa taccaaaata ttatctatga tactattgct ttattttatt ttattttcaa 134280
ttacatatgc ttgtatgtgc atgagagtgc aagtgcccac agaggttaga aggaggtatt 134340
aggtatcctg gagatggagt tacaggagat tatgagctat catatagatg ttggaattaa 134400
acctcagtcc tctggaagag cagccaatga gccatatctc cagccctatc aacctgttgg 134460
gttgtttaaa aataattctt ttatttttat ttttaagtat gtgtgtgttt gtgtgtgtgt 134520
gtgtacatgg gtgcagtacc ctaagagacc ggaagagaac attggattcc cccccccccc 134580
accgccccca cctcccgagc tggagttaca ggcagatgtg tcccttggaa accaaactca 134640
gctcgcctag aagaggactg gactatcgag cctaagcgcc catctaagtc tttgtatcca 134700
gtctttctgc aaccctggaa gcctttttac caaaaagtac attctttcat cctagctgtt 134760
ttttgtgact agcacctgct gaaaaaaaaa aataagaaag aaagaaagaa agaaaaaacc 134820
caaaacatca tcaaaacaac aaaaagccaa gcccaccaac aagaaacgga tatacacaaa 134880
agccaagaaa aacaaaacaa gcccccccaa gccccagcta ttcatcaaga taggaaagag 134940
aaacacccaa ctcctacctg cgcttggtga ttgcttggtg aaaaataaaa gtatttttcc 135000
tctcattcct tcttttgtga tcaaatgaat aatgaaggga ttgagccttt gctagtgtgc 135060
atgcccctgc agggagccaa gaaacaaata ggtttcctaa gggtataacc cagccttttc 135120
ggcttttccg tcatcacgtg attgagggct tctgcttccc acttaacctg catccttccc 135180
agactgattc atggaacctc aagggctcta caggaaaatt caaacatcag cttctctctg 135240
ccataggact tccatccgaa ggaatggttc cttggttgtt gccttcacag ccctcacatc 135300
cgggctggac ctggcagaaa gttgacattt gacccctatc tagagcatag acgatgctgg 135360
cagccgtatg tcctcacttt tgccattccg gtgcctccct cggggcacag ccaaggttcc 135420
gagatgggca ttttcaggag gaaacgattt tatttgaggt cttggcaggg agatgagagg 135480
aggaggcgtg ccaccttctg taacaaaagg catttcccag ccttagacac acccttaggc 135540
ccagatgtac actcccactc ctgtcaatcc aactgcactg actagcaacc ctaatgcctg 135600
ctgcttccag gcaccccgca gcctgcgtct tgtttccact atttcctctg cctgtcgcag 135660
ggaaagcctc actaccaaga gccttcaaac acagttcctg ttactaattt tgccccaaag 135720
ggtaccacag tgattaactt aatgcttccc cagggatgac tctctctgtc tggggtcagg 135780
gtggggctgg atggattttc tttattaagg atggtgggaa ccctcttttg agctttgaag 135840
tctcgcctta gatttttttt taattttatt ttttattttt gataactaca aagggacagg 135900
aagtctcttt ttactcctct gaggcttgct gttctccagg ggcatggaaa atgtacacgt 135960
tgttagcccc ccaagcctgg gggctggggc ccgcgctctg ccggattgtt tttatatccc 136020
agcaaaaagc atctgtgtgc agaacagcag ctggtctgct gctgccaact gcacgttccc 136080
agtaccaatg taagcacttt ccttagaggt taaaaccccc aaggcactgt ttgtgtttgg 136140
agaagaaatg ctctaaaaat agtaagtggg ggtttaaagt ctcttcgtca gatgttcgga 136200
agcacgctga cctggtgcgc tgcttcttag aaccagagct cattggcagg ttgctgtgcc 136260
ttgcacctac gattcctgac tccttcagta agctagctgg tgaagagctg gagaatctgt 136320
atttataata aatccccggg tggggcattg atgttgctga ttttaagaac acacactgtt 136380
gtagccagtc aaaagaccct tactcagaaa gaccacagag accgccgcca tcgctgcaaa 136440
ccgcatgagg atttttattg atccaacatg ttggggacac ccctctcagc acgcaggcca 136500
gaggagagac ccagaacaaa gaaagatcac attttttata cctttgtaag gggcagattt 136560
gagtaacagg gttcttattg gtgtagcaag taaccctttc aggcattggt tggtttgtat 136620
agtgactaag taaccctatg gcccagtgac tactttgctt gcccccatgg tgggttatta 136680
tgatttggtc agcaaagtaa tagtacttta acatcacagc tattaacgtc aagggaattc 136740
tcacaacaag ctcagggtgg tttgtggtct ttgtcagaat tcagtgtggg gcaggggtca 136800
ggagaattgc taatcttgtt atggttactt ctctgagaac agctagtatt gttttggtag 136860
ttgcaagctt aatcattttg accaccaaaa ctatgttttt acatttgttt agtcagccgg 136920
cttccctatc tggctctgca cgtggcctgc aagtacagtt tggaaagtgt ttttcgaagg 136980
aggaaggtac tgggtggtct tgaattcatt ttggatatta caacacaaag aaccactggt 137040
ctggtgtatt tccccccagt ctgttgttgg ctgcagggtg taatacagac acagggttta 137100
ttaccaggga gaggagggta ccatagcttg atgcaattcc ttattacctg tgtcgccaag 137160
agcaagtagc ttaaccttgc tggtctctgt ttcctccctt ccttgacaat catttctata 137220
gagctaattt atatcaggat cttaattatc ttgttttgtg gagggcacat gtttataaaa 137280
cgttgatctt tctccctacc aatatttttt ctcattgtca tttaaagagt cagttttggg 137340
actgacaaga tggcttagtg ggtagagaag gcttgccacc aaccctgatg gtgggagctc 137400
aatctttggg actcacaagg aagaaggaga aaacagactc tgatctgtac acatttaaat 137460
tggcacgtga gcccttctcc tcaaataaag tcacacacac acacacacac acacacacac 137520
acacacagag agagagagag agagagagag agagagagag agagagagag agagagagag 137580
agaaagatac acacacacat cccatacaca ttttttggcc aggttagaca atgctgggga 137640
aagatatcag atttatgcat ctctctctct ctggactgag ttggtgactg tgggaaggga 137700
tgggacttga ctactgcaac ttgtcagagc acagtaggcc actgtgaatt gcagctctca 137760
gactcctggt accatcccat agtccagcac atgggagcta aaagtccaaa taacaacaat 137820
gctgtctgag gacttggagg caggtgacat tgtggtaggg atttgtggat ttcgatgtgt 137880
gtttgttctc tgtttttaac accttccatc agataagttc ctgtcctgtt tcttcagatc 137940
ccaacctgtt ttccatttcc ttggggagcc tttgaaatat gtggctggat ctggatgtta 138000
tgaacttgta tggagttctg cacaagtctt tatagtttca tttgattgca atccaattaa 138060
tgtaaggatc ctccctgaat gatgcgccct gtgaaagcaa actccatgct taatctcttc 138120
cctatacttg tgtagtatgc atttcttgac ttttcatgag acattcagag actatcctat 138180
aaaagtgtgt aagtcataaa agtgtgagat taaaaaaaat agcaggtgca aatgaatcac 138240
attttcttga tccattcttt gggaaacatc tgggttgttt ccagtttctt gctattacaa 138300
atatagctgc tatgtacctg gtagaacaag tatccctgtg gtatggtgga gcatcttttg 138360
ggtacacgcc caggagcggt atagctgggt cttgaggtag aactattccc aattttttga 138420
gaaatcacca agctgatttc cagagtcgtt gtactgttgt ggccggccag cagctcgcaa 138480
cgtgaacgtg actgagatgg ccactcgagc taagggagga actagtcggg gagaaagaag 138540
aaacggagcc aagacaagtt catcctgttc aaagctcaat tttactagtt ctgacattca 138600
gttataaagg aagggggagg gaacccgatt cccgccaact ggtcttggag tccagtagca 138660
gggtgaacac gtgtgtggct ccaagcagca aagcagcacg gtccagcagt gggcgtggca 138720
gaatgaatga gcgggaaact ccacccctga gccagcaggt tccaggctgg gggtggggag 138780
gctgcagttg tacaagtttg cacctgcaat ggaggaatgt tctcttcgct ccacatcctc 138840
accagcattt gctaactctt gagtttttga tcttagccat tctgatagat gtaaggtgga 138900
atctcagagt cattttattt gtattttcca gatgattaag gacattgaac atttctttaa 138960
atgttcctct gacattaaag attcttctgt tgagaattct ctgtttagct ctgtactcta 139020
ttttttaaga ttggattatt tgttttcttg gtgtttaagt tcttgagttc tttatttatc 139080
agtcctctgt cagatgtagg gttgttgaag gtcttttccc atcatgtagg ctgccttttt 139140
ctcctattaa ttatgtccct tgcattatag aaggttttca gtgtcatgag gtccaattta 139200
ttaactgttg atcttagcgc ctgaaccatt tgtgttctgt tcagaaagtt ctcttctgta 139260
tcagtgcatt caaggctatc cccactttct cttctattag ttttagagta tccagtttta 139320
tgctgaggtc tttgatccac ttgcacttga gttttgtgca ggatgataag tatggatcta 139380
tttgcaatct tcctcatgca gacatccagt aggaccagca caatttgttg aagatgcttt 139440
cttttttcca ttgtatggat ttggcttctt tgtcaaaaat caagtgtcta tacatgtgtg 139500
agtttatttc tctgtcttcg attcaattac attgctcagt tattaaaagc aaggacatca 139560
tgaagttttc aggcaaatgg atggaactag aaaatatcat cctgaatgag gtaacccagc 139620
tccaaaatta taagtagata ttagccataa gtatacatac aggataccca agctataaac 139680
cagaaaccca attatgctaa ataacaagga gggctcaagg gaggatgctt aatctcactg 139740
agaaagtgtc ctagtcaggg tttctattct tgcacaaaac atcatgacca agaaacaagt 139800
tggggatgaa agggcttttt caagctacac ctccacattg ttgttcatca ccaaaggaag 139860
tcaggactgg aactcacaca gggcagaaac atggaggcag gagctgatat agatgccatg 139920
aaggggtgct gcttactgga ttgctcccct agcttgctca tcttcccttc ttatagaagt 139980
caggaccacc agcccaggga tggcatcacc cacaatgagc cctcctcgct tgatcactaa 140040
ttgagaagat gccttacagc tgggtctcat ggaggtattt cttcctcaag ggaggctcct 140100
ttctctgtga taacttcagc ttgtgtcaag ttggcacata aaaccagcca gtaaaggagg 140160
agaaacaaaa tagtcattgg aggggatgga gggaaggaac tggttgagag aggggctggg 140220
gagggaaatg gggagttggt catcaggtgt agggagagaa ggggaaaggg ggctgtgaga 140280
gtgaatggaa atttgtggca ggtgggagtg gggtgggggt ggggaggctg ccatatcatt 140340
tctaggatgt gtcagagacc tgggacaggg gaggctccag gtagactatg aggggcctct 140400
agctgagatt ccttgtaatg ggggatatgg agtctgaaat ggtcacttcc tgtggccaga 140460
caggacctcc cagtagaggg aaaaggatac caacccaccc acaaaacctt tgaccctaaa 140520
tttgtcctgc ctacaagaag ttccgggaca aagatggaac agagacaaag ggaacgacca 140580
accaatgacc agcccaactt gagacccgtg ccgtgggcag gaactaatcc ttaagattta 140640
atgatactct tgttatgctt gcagacaaga gcctggcata tctgtcctct gagaggctcc 140700
acctagcagc tgactgaaac agatgcagag actcatagcc aaacattaga cggaacttgg 140760
aaaatgtgga agagttgagg gaaagattga gggacacaga gaggatagga actccacacg 140820
aacaacagag tcaactaacc tggactcttg agagcttcca gagactgaac caccaaccga 140880
gcatgggctg gaccttggca tcctgcattt atgtagcaga tatgcacctt ggtcttcatg 140940
agagtccctc aacaactaga gcagggactg tccttgaccc tgttaactgc ctgcctgtgg 141000
atcctattcc aactgggctg tcttgtctgg cctcagtgga agaggatgtg cctagtcctg 141060
caatgatttg atgtgccagg gtgggttggt acccagcacc cccctcaaag gagaagagga 141120
tgagggagga gctatgtgat gggggtactg ggaagagagg agagatgcaa attggaagta 141180
aagtgaataa ataaataaat taattaatgg aaaaaagtag tgggtgctat gaaggagtca 141240
tctatattag attttctgga gttataacaa aatacttgag agaaatggag ttattttatt 141300
atcgttttgg agataaaagt ccaaataaca gtagtattat ctgtggtaag aactactgta 141360
gatggcactg tgataagaat ttgtcagttc ctatgtctgt aaatgtgtag cgtgtgtgtg 141420
tgtgtgtgtg tgtgtgtgtg tgtgtctgca tgtgcatgta tgtggggtgt ctatgtttga 141480
gatggatatg gatgtgctgt gtgttatatg tatgtgtgat atatgtgctg tgtatgtgga 141540
agttatgtgt gggtatgggt gggggctatg tgtgaaagaa agagagaaac aggataggga 141600
aaggaagtca gagccagacc tatatgggga cagtaatgac ctccttattt agatttatct 141660
cttaagggtt aaagatgaca ttatttttta acattgttgc tccaggacca ggctcctaat 141720
gcatgcagtc tgagagacac attcaaatca tatcctatac acagtaccat cctttggcca 141780
gaatattggt aaaaccatcc aaatgttaga ggagagtagc caacagttct ggcatccgta 141840
tacagcactg ccggcgtaga gtgccctact gccctgaaga tgccctgtga tttcattgaa 141900
aattctttcc agattggtaa cctctcagcc cggctctctg tgccttatag atcatgagat 141960
ctgtaacata caacgtaaca attagcttct cagttcttgt tggagaggct gggtttataa 142020
gaaagaaagc agccaagcac atcagcccac gggagcctgg cataaagtgt acctcagcag 142080
ttccttagtg tttgtagaat aaagtaatgt attatagctt tcctatagat ccacatggaa 142140
gcctgagaag ctatgtggtt ctcctcagac ctcatagtct gctcagattc actcacttgg 142200
gcgggttgta tagctctggg gaagatttca cttctctgcc tcagcaacac aggctcaggc 142260
gcatcctgct ttgggttgtg aagttgaccg gaagtgacac gtatagcttt cagaaagaag 142320
tttgaagagc cagcatgtga ctgaccattc gtgcccttat accttgtttt ttccaaggat 142380
tatgatagag ccacaggcca ttgggtgctg atatttgttt tcatggtgta actaaatctg 142440
tccgcagagc aacacttctt ttttatgaag ataagaagta actgaggcag gtttccaatc 142500
tagacatggt tactgtaggg tctgctactt gctagcttca cccagctgaa tcaagaagag 142560
aaaacaactg gccaagcttg ttgggggcat acatgaaagt ctagtactta ggaggtggag 142620
gcaggaagat aaggagtgga aggtcagtct tgggtgcatt tgtgtgtgtg tgtgtgtgtg 142680
tgtgtgtgag agagagagag agagagagag agagacagag acagagacag agacagagac 142740
acagagagag acagagagag acacagagag agagagacag agagacacag agagagagag 142800
acagagagag agacacacac acacacacac agagagagag agagagagag agagagagag 142860
agagagagag agagatattc cctggaatca ggctcccatt acaagcacta acaattccat 142920
ctgatgcctt gcaaattgtt tcagaggcct gggaaagata ggaaaatttt ctgcctattt 142980
ttagaaagcc aatgtaacat tgtaccaaaa tcttataaag atagcattga aaaaaaagaa 143040
aaccaacatc cgatctcatt gaaggagtaa caaatcctaa attattaaaa taataacagt 143100
tcagcaaagc attaaaatat accaagtgaa gtcccctttt gacaatcaac aacggcacct 143160
taccccacac acattatgac tgactgtgta cccctctaaa ataggacgaa gggggaaaga 143220
atgcattgct tcagaaaatg acccagcaac atatgctagt tatctattta tttttcttgc 143280
cttgacagaa gctagctagt attatctgga agcagggaac aatgtctgtt gagaacctgc 143340
ctctgtccgg attgaactgt cacaaggcaa gtctgtgaag gcattttctt ggtttaataa 143400
ttgatgtggt aggtccagcc ctctgtaggt ggtaccacac tgagtgtgtg gtcctgggtc 143460
gcagggttaa ggaacctgaa catgagcctg gagaggaagc caggaagcag cactccttca 143520
tggcctctgc tccacttcct gctttgagtt tctagcttga attctcttca tgaaaaatta 143580
ttggctgggc tggcgagatg gctcagtggg tgagaacact gactgctctt ccaaaggtcc 143640
tgagttcaaa tcccagcaac cacatggcgg ctcacaatca tatgtaatga gattggacac 143700
gctcttctgg tgtgtctgaa gacagcagca gcatacttat ttatactaat aaataagtct 143760
ttgggccgga gcgagcagag gtcctaaatt caattctcaa caccagatga aggcttacaa 143820
ctaactatct gtacagctac agtgtgtaat catatacata aaataaataa ataaatcttt 143880
taaaaattga aaaattattt ggtgtaaggt aaagaaacaa aaacccaaac accctttcct 143940
tttcaagtcg cttttagtcg tggtgtttat cacaggagct ggaggccatg taagatgcgt 144000
aggatgtagc atttagaagc catgtaggac acctcgttta gtggagctaa gccactagtg 144060
tgatataaga gtccgacgtt aatagacggc tttaccaagg aataatgaat tctgtatttc 144120
aaacggagtc gggattggct tagggttaaa aagaacctag aagtcaaggt tccccaggct 144180
ggggtggctc tgatagacga gtgccaagca cagctgcaga tagcgcaaaa gtatgactta 144240
aaagatacat gctataagga agaaaagtga gggaaaattg caaaatatga aaatagcaag 144300
aaatttcatg tatgtatcaa gtttcccaaa caagggacag gcacacagtc acacagacac 144360
atagacacat agacacacag gcacacagac acacagacag gataggatat taagcactgc 144420
attttgttcc tcttgttgaa accctatgta gtttcattat gtaatccagg ctgtcctccg 144480
actcatgcta ctccggactc agtttcccaa gtgctggggt ttcaggcaca ctgctacctt 144540
gtcccactga aagagttgtg cctgagatgg tcattactta gtgaaggaca gtgagacttc 144600
agcaatggag atggcatcct tgttagtgga tttgtccact taaatgcatt agacaaagtc 144660
tggcttatca tttattatta ttgttattat tattattatt attattatta ttattattat 144720
tattttaagc atagagttag tgattactca ttcctatact ttcctattgt taaggaaaaa 144780
aatctaaaat ggcaaaatca caatgtgaaa tacatatgca aagatcttaa aaccaccagt 144840
ccgtgagtaa accagttcct tttggagaca aaggaatagg cagtaaataa gagaaaacca 144900
catttgttaa tggatgggta gttgttcact ctagccatgg agacactgaa tcagcactcg 144960
acacgattcc tttacatact tacagaggac attgattcgt ttctattgtt actgagtagc 145020
tccaacttcc caggtcacaa gttgccaaga gcagccaatt attcttaagt ttcaatttgt 145080
tgaaaaaaaa aaaagccctg atagcattga tgttcatccc cgagcaactc agtaactcag 145140
tgtgtgtgtg tgtgtgtggg ggggggtgtg tgtgtgtggg agggtatgtc tgtctgtgtg 145200
tctgtgtgca tatgtggaca tacatatgcc atgtcacata tgtggaaatc agaggacaac 145260
ctgcaggagt tagttctgtt cttgaaccat gtggggttct gggaattcga gtcaagccat 145320
taggtttggt gtcaagagct ttttcccgtt gagccatttt agcccataga aactggttct 145380
accacaaaca tttacaagat acaaaagcta aggacactgc ttagtccatt taaaatgata 145440
taggtcccaa agcttcgctt actgtgggat tttctcctat catctcatcc ctttctttca 145500
tctggtcttt aggatccttt tctgaaggtg tgaagttggt agagaagcct actgtgtgga 145560
caggaatgtc tctcaaatgc atcaccattt tgagtagtag tgattgagaa caaagggaat 145620
tgttgtaagg tgtggagtta tttgataagg tgtggttgta acaaagcacc aaaactgggc 145680
cagggagata gcttatcagg aaaagcactt ggtacagcct cctgaatgcc agagttggat 145740
ccctggagtc cacagaaaaa gccgagtgtg gaaagccaga tgcagtgaca ggaatttgta 145800
acttgggcat tcctgggaag agatgaaagg agaagatggg agaatggcct gaagcttaag 145860
ggacagctat gggatgtgtg ctacaagaac agaaactagg gagactctgc ctcaaagtgg 145920
ggtgggaacc aactacacac aggtatgttc aagcagacac cacacacaca cacacacaca 145980
cacacacaca cacacacaca cacacacaca cacacacaca ttattaaagc tgataacagc 146040
ttttagacta agtagaagga aaaagagata actgtagtta acaaaatcta attcccaatt 146100
tgctacctac attccctacc tgcagtatgc taactttaag agggaaaaag tcctccaacc 146160
agagtgtata taaaatatgt tgtctgatcc tcccaatagt ggttttctaa aaggaatatc 146220
atagaagata tttagaagac ttccttttac gttacttttt gagacagggt tttatgtaag 146280
ccaagttgac ctcaaacttt gaatcccact tctctacttc ctgagagcta cagctataaa 146340
tatgcaccat catggctggt ttacatggtg ctggggacag aacccaggac tttgtgatgc 146400
taggcaagtt ctctaccaac tgaggtcgat ccccagccct cagataacat tgtgtggcgc 146460
tattctgtct acccaagaga gtttatagtt tagacttcca gatcaagcga aataaagagt 146520
tctggggaga tgtccttttg cttcctagtg taggtataga tgttacggga tggcaggatt 146580
tagtcagagg aagagactca acttctctga aggtcttact atgcatacaa ctttctgcta 146640
tggttcttat cctgtggcat aaggacatcc cctgccaccc aattttacat gccacatccc 146700
aaatcattgt aacgaggctt cacatggcaa ccagcagttg actgcaatga gacttccatg 146760
gcaaccagca gttgactgta acaaggcttc catggcaacc agtagttgac tgcaacaagg 146820
cttccatggc aaccagcagt tgacacctgc cttgctctgg ttttgttaca gctgaactgt 146880
ttctcatctg tgaaacccct ttttaaaaca tgtattcatt tatcttatat gtgtacactg 146940
tagttatctt cagacacacc agaagaggac atcagatccc attacagatg gctgtgagcc 147000
accatgtggt tgctgggaat tgaactcaga acctctggaa gagcagccag tgctcttaac 147060
tgttgagtca tctctctggc acccccgctc ccatgaaacc cttttgcata tatctttttg 147120
tcttctagtc ttgtggtcca caagccctac aagtcacttt tggagttctt ccttagcccc 147180
actcccacat tcttgctttg gattatcttc gacattcagt gctctcaggg cagctgtgaa 147240
cctccttgaa aaattttctc tcttgtctgg tctctaatga tgtgtagact tgacttacta 147300
ggggttcatg tcttgctctc tctttcatgc agttcaattc atatttagca tcctaagtca 147360
gtgactatag ggaaaggttt tgagccccct tggaagtctc tgctgcaagc atagatcttg 147420
cagagtagat atttaatgaa ctcttattaa atccatgcat gaatgaaact cttcatgtgt 147480
atttcccaat cttctctcta catcattgaa aggggaataa cagaatttaa attcttcaca 147540
attcctgcaa agggagactt ctactaagta tgaaatgtgc aaggcttgaa tttgtaatga 147600
atgtctgatg taacccagca ttcccagaat caccacttgg gttttccaca agggtatgca 147660
ttcctctttt atacaaatgc atggaggggg aggggttaca ggataggcag aaatgaaaga 147720
tatttgttaa ttttctgtta ttgtgataaa acactatgat caaggaaact aatcgaagaa 147780
aaaagtttat gtggggttat ggtggccgag gattagagtc catagcttgc aatggaggtt 147840
gcaggtaacc agaacagaac aggctcacat ccctgtcttc aagcaggaaa cagaaagcat 147900
gcggagtggt gtaaggcatt aaacctcaaa ggccatccca caggtcacac ttcctatacc 147960
tccccaaaca gtgccaccaa ttgggaacca aacatcagag tctgtggagg acatattcgt 148020
tcaaaccacc accacagaca agtagtttat tctgtgcacc cttcttatgg aggaggctga 148080
caagtaccac tgtttacaca cagtaggact gccacgaaca atatagccat actcactacc 148140
tgctttcccg gtttgtggcc ttcccatacc tcacagaact ttcttcttcc tgcctgtaca 148200
tttcactgct gtctcttgct gtggagtggg gctctatatg tgcgagggtc tcagtgtgaa 148260
gcaggctctg tgctacttgt cttatcctga gttacagaga ttattttttg tcccagtccc 148320
tatcaggagt cactattttg agcccaatct ggtagctctg gtttcttctt tccagaatat 148380
tctgagtcgc gcagcctcaa accggctctg cctttcctct acatgcctgt gatgacgact 148440
gcctggctgc agatgctccg ggtgttttcc cacaccagtt tctcttgttg tgactccatc 148500
aaacccaggt cagcttctgt aatcgagacg atccacttaa ttaactgtaa tgaggctccc 148560
atcatttcca ataaatttct ttccaaaaca ccacttgaga ggcacatagc ttcctatcag 148620
ctgtaaattt tttttttcct gtctatttag ttccaggaat tgaatttact cagagatgtc 148680
attgcccaac ctcatgtctc aatgttttaa actaaatctt tcagtctggt gctatgggct 148740
acaggaccca accccagttt cccttgtaca gaatggaaga tgccgtgcaa acagcttgtc 148800
tgggtttcac cagagctggg agaatcagtg ctggttttca tggcctcttc tgcgatcagc 148860
cccttctcca ccaacagttt tgttagttag acagagcaac ttgcgcttga agatctcaaa 148920
ccatttatcg aagcatgcca tcttctcctt tttaaagacc tgaaatgctg ttggaataat 148980
tttgctgtgt tttataaaaa tatagagagg attaatacgt ttggtagagg tgcaataagg 149040
tgtggaggga aggggtgcct ccaaaggcct gtgctgaggc acctcttccc cctgagcgac 149100
cagccaaaga atggtatagt atagaataga gtttattcat ggcatgggga ggggagttga 149160
gagagtagta gagacagaga aagagagagg gagagagaga aagagagaga gagggggggg 149220
agggagggag gaagggagag agagagagag agagagaggg agggagagag agagagaaga 149280
gtagtagagg ctggtcatga gcatgtggag agagaggggg aggggaatgg ggaatggggg 149340
agcaggaggg agaggacaga gtcggagcaa gaaagcaaga gagaacagag gggctaagca 149400
gtcccccttt tttcatttta aaaattttat tagatatttt ctttttttac atttcaaatg 149460
cttcctatac cctcccctcg ccctgctccc ctacccaccc atagcagccc cttttatagt 149520
gagtcaggca cacctggctg ttgccaggta actggggcag agcctataca aaaatgctaa 149580
cagatttgtc agtgaaatga tattttgctc tttgacttat agaagatgaa aaagaaaacc 149640
acaagtttca tactgaccct ttggggagga tacatcttta agaaattatg ggagagaata 149700
gtttcattta gaaagaattt aagtgttttt ttttcccctc tcagacatgt catggtttaa 149760
tatcagttat ccaatttttc tttgtgctac tctcagaatt cttcctgaga aattagcttt 149820
aatcttctgc tttgtttcaa agcctgcact agattaagcc tcgtcctctc tctctctcct 149880
ctctctttct ctttggcttc attcgggaat gactaattag ccaggagaaa ttaaatttac 149940
aaattaaacc tctctgcata gattttctca agaccccagc cctgggggta atatccatgg 150000
cctctcctac agagcttttg cctcccagag ggttgtatag aggggtgaaa tgtttatgaa 150060
gccacatcgg cttgaagagc aggttggtgg ttggcggttg gcagcattat aagttgttct 150120
ttggttcctt cagggaaaaa cttcagtgtt ccaaagttca gggtcatgga aggagggtga 150180
ggaatgttcc cagccagaga agaaagtgat gtgtgtgaga gagaactgcc gagaactgta 150240
gaactgaagt ttccaccgct ccaattacat gcctgaatgc cttcttttca tttcatctct 150300
gtttattatc tttgtctgtg tgtggatggt gtatatatgg tatgtgcatt tatgtgtgtg 150360
agtgtacact tatgcatata aattcaagtg ctcatgtttt actccacgta taaagagatc 150420
agaggacagc cttgggtatt gttcattgcc tttcaccttt ctctttctct ctcttgaata 150480
caccacctat cattgtagga gactggcatc acagacctgc catggctggc tttgtatggg 150540
atgcagggat gtgaatccag gtcctgatgt ctatgtggca tagacactta actaggaccc 150600
caacccattc acctcccaag cctgactctg ctcccctgct ccactctaca acatgccctc 150660
tactcgataa aggcactaaa atgtgtgact aggggccatc cagtttgttc tgagtgtcag 150720
ctcatgcctc cttcttagga agcatttcaa gccaatgtct cttaatacca cccacggttc 150780
attgttttct ggcttctcct tccttccttc cttccttcct tccttccttc cttccttcct 150840
tccttccttc cttcctccct tcctcccttc ctcccttcct cccttcctcc cttcctccct 150900
tcctcccttt ctcccttcct tgctttttct ttctaacatc ttttgtgtat tgaaaatgct 150960
gatgtttttg ctatttgggg atgagctctt gcaggatagt gttccccaac tcttctcttc 151020
caagtttatt ctccagatct ttgcattaag ttaggcaggc tcctttaggg acagagaccg 151080
acggcttact ggaggggaag gcttcagtcc cattaaaaga tggttaatga acattcaaag 151140
ttagtgtttc tctttgtttc agctgcagat cttttggaga atcttaggag aaagcagcca 151200
agaccactga atccacctga cctcattaac ctggagcaaa ctgggcttat tagaatttag 151260
attgaaggcc tcagaggtta gatattgctc ttggagaaga cctaggttca gttcctagca 151320
cccacatagg tcggattaca attgctgata actccagttc caggggatct gtcactttct 151380
tctgaccttc caggtcttca tgcacattgt gcacatacag acaagcacac gcacacacac 151440
acacacacac acacacacac acacacacac acacaaatat taaaactctg gagtgtgaac 151500
ttagtatgcc cataggtaat tatgtccatt agctttcctc attggacatt ttctctgtca 151560
cctttaactc aggatgctca caaatatccc tacccctcta cgtacttcct ttatgaattt 151620
gtatatgccc cttcccttgt ttggggagca gatgtttctc tactctttga tctgactgtt 151680
gtgctcactg gtttcatact caccaagaga cctgattcga cttaggtacc gagtcaccca 151740
cgtctctcag ggtcagcctg ctctgtctct cagtttttgg tctaagaaaa caaggccttc 151800
cacccttttg atcagcagat atgagtaaaa gaaataaaag ttgatgctct ttgttttcca 151860
gggattcaga taaaatgttt gccatatgca tgaaataatt tttaagaggt aggttggttc 151920
ttccccctaa agcaaggttt atctaagaag agtgctttta aggatggtcg tgatgctgac 151980
agtacctcgc attcctaccg tcatttctgg aaaagccatt ttaatttttc atctcacctc 152040
gccatctggg agacaagtga actcaatgtt ttccttgcca tttataaagt gagttagtta 152100
agactcgggt aagactattg atctgcacca agatccaata ccaggaaaag agatgaaatt 152160
ggtatccaaa cttttgtttc aggactctga gccctggcct ctattgtctc aaacacagtt 152220
caatcataaa ctgagtcaat acatctagca ctgcctggca gtataaggca attaaactat 152280
cacaaggcta tgggggtaaa gacactatca caaaggtctg ggataaataa acttgaacag 152340
gttgataaag tgtgggactc aatctctaaa ggaggtgctg taatctctct gtagtggaag 152400
gtttacctga aggaacagat ttgaagttat tcctgaaagc atactaaaac cagaagacag 152460
tttggcagtc cgaatcaaaa actttaacta aagacatgaa ccacagtact ttccagcata 152520
tcactcagtg gctctaaagt tcttttcctt gtttgaaaac aatagagtcc aggggaggat 152580
taaatggtga tttgtaaagt gccaggctca gggcacattc agtaaatgtt accagtgatt 152640
gcagaataat ggtgataata ttttcctttg taggaggaaa taatgagcac gtagatttag 152700
caacacacag atcgtttgtt gtgcttttaa aagtcacagt gaaaagttgg aaacaacttg 152760
atgtccagca agagggaatt gcagaagaga gtttcctggt atttctaggt gctagatcat 152820
tagatagcca tgtaaaagaa taaaaggaaa taaatatgtt attgcctagc aagatggcca 152880
tgaatttgtt gttgttgttg ttattaagac agggtttctc tctgtagccc tggctgacct 152940
agatctatag accaggctgg cctcaaactc aaagatcgat ctgcatctgc ctcctgagtg 153000
ctggggttaa aggcttccac cactgctgcc tggctataaa tgtttaaaat atattttcta 153060
ttaattcttc acaaattcca tatatgtgta cagtgtattt tgaccatatt cacccctact 153120
cctcttccca acccctttca gctcccctgc tgccatattt ccatccctta ccaattttgt 153180
gtactattta attaatagat atatacatat atatatttaa ttctgatata tcagcacatt 153240
atatattata ttatattata tgttacatat attatctgtt acataatata catgtataca 153300
tgtatgtata tatatatata tatatatata tatatatata tatatatata tatacatatt 153360
gatgtacacc cattcattgg agtctggatg ccttgccagg gaccactctt aagcaaagtg 153420
gcctctccct gatctggaag tcccttgact gttaacagat ccttagctag ggctggagac 153480
ttgggagccc catgcctctc taagcaggaa tcctgacttg gtcttgggct gccactgtga 153540
gctcatgagg cagtgttggg ggagggatgc tttataccat cccctttgtg actgagaatt 153600
ccacaaatgc tcattctctg cacttggcag tgatttttta cctttcaaaa acacttataa 153660
aatattaaat cctttttttt taagtttgtg cttttttgat gttgtttaac acatatattc 153720
atgtacagat acaggatagc tttaaaaact aggagatgaa tttgcagctc tatgtcaaca 153780
aaactgacat ttaaaaattg tttttattaa aattcttttt atttaaacta tcccagtaac 153840
aaaggcaagt atcatgtaaa ataaaattgt gctgttttgt tttgtttctg gctttcttgt 153900
ttcctactct ttcctttggt ttgtcagctc tgtgctacca taagcagaca cgatccattc 153960
aatagttgac taacagcatt cttttgagtg tttactgtgg ccaaggccct ggttctaagc 154020
acttgatgta cagataaacc agatgaacaa caatgccctt caaaagctta aattcaaggc 154080
tggagaaatg gctcagtggt taagagcact gtctgctctt ccagaggacc caggtttgac 154140
tcccagctcc cacatggcag cttataacca tctacagctc cagtcctggg aggtctgaca 154200
ctctggtacc cacgtggtac atataaatat atgcaagcga gacatgtgca catataattg 154260
aaatataggt atagtgatct tgggattcca gtgtctgaag caggagaagg atgagactga 154320
gatcagcctg gaataagatc ctcttttgat taaaacaaaa gcatgtacta ggtgacatga 154380
acagcacaac cgcaagagaa ggagagtaga ccaaaatttc tagaggagct atgccttctt 154440
aacagcattc aacccctctt ctgagaatcc ctgcagactg ccctccagca tcactgattt 154500
ccatagaggc tgcatagctg tcaaagttca cagtctactc agaggtaacc tgctgtgtca 154560
atatttgtaa tttgtacttc atggtgagtc acttccagag aatagattat ctaccatgga 154620
agggaaaagg tctgggagtg aaagtgagct ggacaagaca caggtggagg cattaggttt 154680
caacagcttc ctgcctctac aaagcaaagg gcaggaatgt gtgctggcgt gggctggagc 154740
ccagaacagc cacaactctc aagtggagga taagcagaaa gcagggttag tctcctgttt 154800
ctccaggtgg ttctagctga ttcttctagg tctggaaaca aatgttacct tctatccatt 154860
ttctctcctt ctcccctggc ttccattttt atagctcaga agcaaatcca tcttttaaga 154920
gttgttctca agcaatcttt gtctaaagct ggatcctcac catactacat cccacttcac 154980
ccccacctcc accctcactg ccaattgagg aagttctctg aattctgaca cctccatagc 155040
atgtgatagt cccctatgtt attcctatgc atcaattcat ttttacattg tgctggagaa 155100
ctccatctct cttacaagag tagatgatca ttaaggtttg gtctatagaa ctccaaatag 155160
actggactag aaaagaaatt ccttctgaca cataataatc agaacaacaa atgcactaaa 155220
taaagacaga atattgaaag cagtaaggga aaaaggtcaa gtaacatata aaggcaggcc 155280
tattagaatt acaccagact tctcaccaga gactatgaaa gccagaagat cctggacaga 155340
tgttatgcag accctaagag aacccaggcc aggctactat acccagccaa actctcaatt 155400
accatagatg gagaaaccaa agtattccat gataaagcca aattcacaca atatctttcc 155460
acaaatcgag cccttcaaag gataataaag ggaaaacacc aacacaagga cagaaactac 155520
accctagaaa aagcaagaaa ataatctttc aacaaaccta aaagaagact gcagcaagaa 155580
cagaatccaa actttaacaa caaaattaac aggaagcaac aattactttt ctttgatttc 155640
tcttaacacc agtggactca attgcccaat gaaaagacat agactaatag actggctaca 155700
caaacaggac ccaacatttt gctgcttaca ggaaacccac ctcagggaaa aagacagaca 155760
ctacctcaga gtgaaaggct ggaaaacaat tttccaagca aatggtctga agaaacaagc 155820
tggagtagcc attctaatat cgaataaaat cgacttccaa cccaaagtta tcaaaaaaga 155880
caaggagggg cacttcatac tcatcaaata taaaatctac taaggtaaat tctcaattct 155940
taatatctat gctccaaata taagggcagc cacattcatt aaagaaactt tagtaaagct 156000
caaagcacac attgcacctc acacaataat agtgggagac ttcaacacct cactctcacc 156060
aatggacaga tcctggaaac agaaactaaa cagagacaca tggacactaa cagaagttat 156120
aaaacaaatg gatctaatag atatctacag aacatcttat cctaaaaaaa aggatatacc 156180
ttcttctcag cacctcatgg taccttctcc aaaattgacc atataattgg tcacaaaaca 156240
ggcctccata gatacaaaaa tattgaaatt atctcatgca tcctacctga tcaccacgga 156300
ctaaggctga tcttcaataa cagcataaat aatagaaagc caacattcac gtggaaactg 156360
aacaagactc tactcaatga ttccttggtc atagatgaaa taaagaaaga aattaaaaac 156420
tttttagagt ttaatgaaaa tgaagccaca acatacccaa acttacggga cacaatgaag 156480
gcagtcctaa gaggaaaact catagcccca agtgcctcca aaaagaaact agagagagca 156540
tacactagca gcctgcagca cacctagaag ctctagaact aaaggaagca aattcaccca 156600
agaggagtag atggcaggaa ataatcaaac tcagggctga aatcaaccaa gtggaaacaa 156660
aaagaactat tcaaagaatc aaccaaacca gaagctggtt ctttaagaaa atcaacaaga 156720
tagataaacc cttagccagt ctaactagag ggcacttgta tccagtctaa ctagagggac 156780
agtatcctac ttaacaaaat caaaaatgaa aaaggagaca acaacagatc ctgaggaaat 156840
ccaaaacatc atcagatcct accacaaaag tctatactca acaaaactag aaaacctgga 156900
tgaaatggac atcttcctag gcagatacca ggtaccaaag ttaaatcagg attagattaa 156960
cgatctaaac agtcccattt ctcctaaaga aatagaagca gtcattaata ggctcccaac 157020
caaaaaaaaa aaaaaaaaaa accaggacca gatgggttta gtgcagagtt ctatcagacc 157080
ttcaaagaag atctaattcc aactctcctc aaactattcc acaaaataga aacagaaggt 157140
actctaccaa attcattcta tgaagccaca attactctta tacctaaacc acacaaagat 157200
ccaacaaaga aagagagctt cagaccaact tcccttatga atatccatgc aaaaatactc 157260
aataaaatcc ttgcaaaccg aatctaagaa catatcacaa tgatcatcca tcatgatcaa 157320
gtaggcttca tcccagggat gcagggatgg cttaatatac ggaaatccat caacataatc 157380
cactatataa gcaaactcaa agacaaaaac cacatgatca tcttgttaga tgctgagaaa 157440
gcatttggca aaatccaaca ccccttcatg ataaaagtct tagaaagatc aggaatttga 157500
ggcccatacc taaacataat aaaagcaata tacagcaaac cagtagccaa cctcaaacta 157560
aatggggaga aactcaaagc aatcccacta aaatcaggga ctagacaagg ctgcccactt 157620
tctccgtact tattcaatat agtacttgaa gtcctagcca gagcaattag acaacaaaag 157680
gagatcaagg ggatacaatt tggaaaggaa gaagtcaaaa taatcactat ttgcagatga 157740
tatgatagtg tatatataag tgatcttata aattccacca gagaactcct aaacctgata 157800
aacaccttca gtgcagtagc tggatataaa attaactcaa acaaatcaat ggcctttctc 157860
tacacaaagg ataaaagggc tgagaaagaa attagggcaa caacacccat cacaataggc 157920
acaaataata taaaatacct tggtgtgact ctaactaagg aagtgaaata tctgtatgat 157980
aagaacttca agtctctgaa gaaataaatt gaagaagatc tgagaggatg gaaagatctt 158040
ccatgcagga ttaattggca ggattaatat agtcaaaatg gctattctgc caaaagcaat 158100
ctatagattc aatgcaatcc ccataaaaat tccaacataa ttcttcactt agttagaaag 158160
ggcaatttgc aaattcatct ggaataataa aaaacatagg atagtaaaat ctattctcaa 158220
caataaaaca acctctggtg gaatcaccat acctgacctt aagctgtact acagagcaat 158280
tgtgatgaaa actgcctggt actggtacaa tgacagatag gtagatcaat ggaatagaat 158340
tgaaggccca gcaatgaatc cacacagctg tggtcactgg atctttgaca aaggagctaa 158400
aaccatccag tggaaaaaag gcagcatttt caacaaatgg tgctggcaca attggcggtt 158460
accatgtaga agaatgggaa ttgatccatt cttttttttt ttttttttcc attttttatt 158520
aggtatttaa ctcatttaca tttccaatgc tataccaaaa gtcccccata tccacccacc 158580
cccactcccc tgcccaccca ctcccccttt ttggccctgg tattcccctg tactggggca 158640
tataaagttt gcaagtccaa tgggcctctc tttccagtga tggccgacta ggccatcttt 158700
tgatatatat gcagctagag tcaagagctc cggggtactg gttagctcat aatgttgttc 158760
cacctatagg gttgcagatc cctttagctc cttggctact ttctctagct cctccattgg 158820
gagccctatg atccatccat tagctgactg tgagcatcca cttctgtgtt tgctgggccc 158880
cggcatagtc tcacaagaga cagctacatc tgcgtccttt caataaaatc ttgctagtgt 158940
atgcaatggt gtcggcgttt ggatgctgat tatggggtgg atccctggct atggcagtct 159000
ctacatggtc catcctttca tctcagctcc aaactccgtc tctgtaactc cttccatggg 159060
tgttttgttc ccaaatctaa ggaggggcat agtgtccaca cttcagtctt cattctcctt 159120
gagtttcatg tgtttagcaa attatatctt atatcttggg tatcctaggt ttggggctaa 159180
tatccactta tcagtgaata catattgtgt gagtttcttt gtgaatgtgt tacctcactc 159240
aggatgatgc cctctaggtc catccatttg gctaggaatt tcataaattc attcttttta 159300
atagctgagt agtactccat tgtgtagatg taccacattt tctgtatcca ttcctctgtt 159360
gaggggcatc taggttcttt ccagcttctg gctattataa ataaggctgc tatgaacata 159420
gtggagcatg tgtccttctt acctgttggg gcatcttctg gatatatgcc caggagaggt 159480
attgctggat cctccggtag tactatgtcc agttttctga ggaaccgcca gactgatttc 159540
cagagtggtt gtacaagcct gcactcccac caacaatgga ggagtgttcc tctttctcca 159600
catcctcgcc agcatctgct gtcacctgaa tttttgatct tagccattct gactggtgtg 159660
aggtggaatc tcagggttgt tttgatttgc atttccctga tgattaagga tgttgaacat 159720
tttttcaagt gcttctctgc cattcggtat tcctcaggtg agaattcttt gttcagttct 159780
gagccccatt ttttaatggg gttatttgat tttctgaagt ccaccttctt gagttcttta 159840
tatatgttgg atattagtcc cctatctgat ttaggatagg taaagatcct ttcccaatct 159900
gttggtggtc tttttgtctt attgacggtg tcttttgcct tgcagaaact ttggagtttc 159960
attaggtccc atttgtcgat tttcgatctt acagcacaag ccattgctgt tctgttcagg 160020
aatttttccc ctgtgcccat atcttcaagg cttttcccca ctttctcctc tataagtttc 160080
agtgtctctg gttttatgtg aagttccttg atccacttag atttgacctt agtacaagga 160140
gataagtatg gatcgattcg cattcttcta cacgataaca accagttgtg ccagcaccaa 160200
ttgttgaaaa tgctgtcttt cttccactgg atggttttag ctcccttgtc gaagatcaag 160260
tgaccatagg tgtgtgggtt catttctgga tcttcaattc tattccattg gtctacttgt 160320
ctgtctctat accagtacca tgcagttttt atcacagttg ctctgtagta aagctttagg 160380
tctggcatgg tgattccgcc agaagttctt ttatccttga gaagactttt tgctatccta 160440
ggttttttgt tattccagac aaatttgcaa attgctcctt ccaattcgtt gaagaattga 160500
gttggaattt tgatggggat tgcattgaat ctgtagattg cttttggcaa gatagccatt 160560
tttacaatgt tgatcctgcc aatccatgag catgggagat ctttccatct tctgagatct 160620
tctttaattt ctttcttcag agatttgaag tttttatcat acagatcttt cacctcctta 160680
gttagagtca cgccaagata ttttatatta tttgtgacta ttgagaaggg tgttgtttcc 160740
ctaatttctt tctcagcctg tttattcttt gtatagagaa aggccattga cttgtttgag 160800
tttattttat atccagctac ttcaccgaag ctgtttatca ggtttaggag ttctctggta 160860
gaatttttag ggtcacttat atatactatc atatcatctg caaaaagtga tattttgact 160920
tcctcttttc caatttgtat ccccttgatc tccttttgtt gtcgaattgc tctggctaat 160980
acttcaagta ctatgttgaa aaggtaggga gagagtgggc agccttgtct agtccctgat 161040
tttagtggga ttgcttccag cttctctcca tttactttga tgttggctac tggtttgctg 161100
tagattgctt ttatcatgtt taggtatggg ccttgaattc ctgatctttc caaaactttt 161160
atcatgaatg ggtgttggat cttgtcaaat gctttttctg catctaacga gatgatcatg 161220
tggtttttgt ctttgagttt gtttatataa tggattacat tgatggattt tcgtatatta 161280
aaccatccct gcatccctgg aataaaacct acttggtcag gatggatgat tgctttaatg 161340
tgttcttgga ttcggttagc gagaatttta ttgaggattt ttgcatcgat attcataaga 161400
gaaattggtc tgaagttctc tatctttgtt ggatctttct gtggtttagg tatcagagta 161460
atagtggctt cataaaatga gttgggtaga gtaccttcta cttctatttt gtgaaatagt 161520
ttgtgcagaa ttggaattag atcttctttg aaggtctgat agaactctgc actaaaccca 161580
tctggtcctg ggcttttttt ggttgggaga ctattaataa ctgcttctat ttctttaggt 161640
gatatgggac tgtttagatg gtcaacttga tcctgattca actttggtac ctggtatctg 161700
tccagaaatt tgtccatttc gtccaggttt tccagttttg ttgagtatag ccttttgtag 161760
aaggatctga tggtgttttg gatttcttca ggatctgttg ttatgtctcc cttttcattt 161820
ctgattttgt taattaggat tttgtccctg tgccctttag tgagtctagc taagggttta 161880
tctatcttgt tgattttctc aaagaaccaa ctcctcgttt ggttaattct ttgaatactt 161940
cttcttgttt ccacttggtt gatttcaccc ctgagtttga ttatttcctg ccgtctactc 162000
ctcttgggta aatttgcttc ctttttttct agggctttta gatgtgttgt caaggtgcta 162060
gtatgtgctg tctctcgttt cttcttggag gcactcagcg ctatgagttt ccctcttaga 162120
aatgctttca ttgtgtccca taggtttggg tacgttgtgg cttcattttc attaaactct 162180
aaaaagtctt taatttcttt ctttattcct tccttgacca aggtatcatt gagaagagtg 162240
ttattcagtt tccacgtgaa tgttggcttt ccattattta tgttgttatt gaagatcagt 162300
cttaggccat ggtggtctga taggatacat gggacaattt caatattttt gtatctattg 162360
aggcctgttt tgtgaccaat tatatggtca attttggaga aggtcccgtg aggtgctgag 162420
aagaaggtat atccttttgt tttaggataa aatgttctgt agatatctgt caggtccatt 162480
tgtttcataa cttctgttag tttcactgtg tccctgttta gtttctgttt ccacgatctg 162540
tcctttgaag aaagtggtgt gttgaagtct cccactatta ttgtgtgagg tgcaatgtat 162600
gctttgagct ttactaaagt gtctctaatg aatgtggctg cccttgcatt tggtgcgtag 162660
atattcagaa ttgagagttc ctcttggagg attttacctt tgatgagtat gaagtgtccc 162720
tccttgtctt ttttgataac tttgggttgg aagtcgattt tatccgatat taaaatggct 162780
actccagctt gtttcttcag tcgatttgct tggaaaattg ttttccagcc tttcactctg 162840
aggtagtgtc tgtctttttc cctgagatgg gtttcctgta agcagcagaa tgttgggtcc 162900
tgtttgtgta gccagtctgt tagtctatgt ctttttattg gggaattgag tccattgata 162960
ttaagagata ttaaggaaaa gtaattgttg ctccctttta tttttgttgt tagagttggc 163020
attctgttct tgtggctgtc ttctttttgg tttgttgaat gattactttc ttggttgttc 163080
tagggcgtga tttccgtcct tgtattgctt cttttctgtt attatccttt gaagggctgg 163140
attcgtggaa agatattgtg tgaatttggt tttgtcgtgg aatactttgg tttctccatc 163200
tatggtaatt gagagtttgg ccgggtatag tagcctgggc tggcatttgt gttctcttag 163260
tgtctgtata acatctgtcc aggctcttct ggctttcata gtctctggtg aaaagtctgg 163320
tgtaattctg ataggccttc ctttatatgt tacttgacct ttctccctta ctgcttttaa 163380
tattctatct ttatttagtg catttgttgt tctgattatt atgtgtcggg aggaatttct 163440
tttctggtcc agtctatttg gagttctgta tgcttcttgt atgatcatgg gcatctcttt 163500
ttttatgttt gggaagtttt cttctattat tttgttgaag atattagctg gccctttaag 163560
ttgaaaatct tcattctcat caattcctat tatccgtagg tttggtcttc tcattgtgtc 163620
ctggattacc tggatgtttt gagttaggat ccttttgcat tttgtatttt ctttgactgt 163680
tgtgtcgatg ttctctatgg aatcttctgc acctgagatt ctctcttcca tttcttgtat 163740
tctgttgctg atgctcgcat ctatggttcc agatctcttt cctagggttt ctatctccag 163800
cgttgcctcg ctttgggttt tctttattgt gtctacttcc ccttttagtt ctagtatggt 163860
tttgttcatt tccatcacct gtttggctgt gttttcctgc ttttctttaa gagcctgtaa 163920
ctctttagca gtgctctcct gtaaatcttt aagtgactta tgaaagtcct tcttgatgtc 163980
ctctatcatc atcatgagaa atgtttttaa atctgggtct agattttcgg ttgtgttggg 164040
gtgcccagga ctaggtgggg tgggagtgct gcgttctgat gatggtgagt ggtcttgatt 164100
tctgttagta ggattcttac gtttgccttt cgccatctgg taatctctga agctagctgt 164160
tttagttgtc actgttaaga gcttgttctt caggtgactc tgttagcctc tatgagcaga 164220
cctggagggt agcactctcc ttagtttcag tgggcagagt attctctgca ggcaagctct 164280
cttcttgcaa ggcaggtacc cagatatctg gtgttcgaac cagactcctg gcagaagttg 164340
tgttccactc actagaggtc ttaggatcac gtgtggaatc ctgtgtgggc ccttgcgggt 164400
gtcaggcgac tcagctggca aggtagccgg ggctcgagtg gagtggaagg ggtttgtgcc 164460
ccagatcaag cccgggtagc ctgcttccct atgtaccgca gtctcaagtt ccacgcgatt 164520
ggattggggt aggcgctgtg ttccactcac cagaggtctt agggtcccgt ggggagtccc 164580
gtgtggaccc ttgcgggtgt tgggcaagac tctgctggca aggtagcccg gggctcgagt 164640
ctcgagtcga gcagaaggga cttgtgcccc agatcaggcc cgggtagcct gcttccctat 164700
gtaccgcagt ctcaagttcc gcgcgattgg attggggcag gcactgtgat ccactcacca 164760
gaggtcttag ggtcccgtgg ggagtcccgt gtggaccctt gcgggtgttg ggcaagactc 164820
tgctggcaag gtagcccggg gctcgagtct cgagtcgagc ggaagggact tgtgccccag 164880
atcaggcccg ggtagcctgc ttccctatgt accgcagtct caagttccgc gcgattggat 164940
tggggcaggc actgtggtcc actcaccaga ggtcttaggg tcccgtgggg agtcccgtgt 165000
ggacccttgc gggtgttggg caagactctg ctggcaaggt agcccggggc tcgagtctcg 165060
agtcgagcgg cgaattgatc cattcttatc tccttgtaca aagctcaaaa gtaagtggat 165120
taaagacctc catataaaag cagagacact gaaatttata gaggagaaag tggggaaaag 165180
cctcgaagat atgggcacag gggaaaaatt cctaaacaga acagcaatgg cttgtgctgt 165240
aagatcaaga attggaaaat ggaacctcac aaaattgcat agcttctgta aggcaaaaga 165300
caccgtcaat aagacaaaaa ggccaccaac tgattgggaa aggattttta ccaatcctaa 165360
atctgatatg ggactaatat ccaatatata caaagagctc aagaagttag actcccgaaa 165420
ttcaaataat cccattaaaa acggggtaca gagctaaaca aagaattctc aagtgaggaa 165480
taccaaaggg ctgagaagca cctgaaaaaa tgttcaacat ccttaatcat cagggaaatg 165540
caaatcaaaa caaccttgag attccacctc acaccagtca gaatggctaa gatcaaaaat 165600
tcaggtgaca gtagatgctg gcgaggacgt ggagaaagag gaataatcct ccattgctgg 165660
taggattgca agcttgtaca accactctgg aagtcagtct tgtggtttct cagaaaattg 165720
gacatagtac tgctggaaga tccagcaata cctctcctgg gtatataccc agaagatgtt 165780
ccaactggta ataaggacac atgctccact attttcatag cagtgttatt tataatagcc 165840
agaagctgga aagaacccag atgtccctca acagaggaat ggataaagaa aatgtggtac 165900
atttattcaa tggagtacta ctcagctatt taaaacaatg aatttatgaa attcttgggc 165960
aaatggatgg atctggagga tatcatcctt agtgaggtaa cccaatcaca aaagatttca 166020
ccagatatgc actcagataa gtggatatta acctagaaac ttagaatacc caagatacaa 166080
cttccaaaac acaagaaaat caagaagaag gaagaccaat atgtggatac ttagaataag 166140
gaacaaaata gccatgaaag gagttataga gatgaagttt agagttaaga caaaagggtg 166200
gactatccag agactacccc atcttgggat ccatcagcca ctaaacccag atactattgc 166260
atatgccagc aagattttgc tgaagggacc ctgatatagc tgtctcatat gaggctctgc 166320
cagtgcctgg caaatacaga agtggatact cacagtcatc tattggatgg aacacagggc 166380
ctccaatgga ggagctagag aaagtaccca aggagctgaa gggatctgca accctataga 166440
tggaacaaga atatgaacta accagtaccc ccagaggtca tatctctagc tgcatatgta 166500
gcagaagatg gcctagtcgg ccatcagtgg gaagagaggc ccctaggtct tgcaaacttt 166560
atatgcccca gtacagggga acgccagagt caagaagtgg gagtgggtgg gtaggggatc 166620
agggtcggga gagggtatag ggaactttcg ggatagcatt tgaaatgtaa ataaagaaaa 166680
catctaataa aatagcaata aagaataacc actacaaaga gagaaaagga caacaaaagc 166740
ctgcagtaag tttgctagct gaacagagca gatgaataac cggcagcaga ctttgcacca 166800
catcatttcc tttggccatc cgcacagatt gccggaacag gcaaaccaga tctccatgca 166860
ttctgttgtc cccaccctct gggccatagg acttggacaa aggtaatgtc ctggatctga 166920
aagaagttaa gacactggga tggtatttaa ttaaataata acagaggctc aactcggtga 166980
ttggcctggc tggaccagcc tgatgtgttg ataattgtct aatcctctag tggatatcaa 167040
aaaaaatcat tgctttccca agggaagggg acagccagga gaaggagagg tatacatgga 167100
tgataaacgt tccagatact ggctaagtgc ttaccagtaa attgaagtcc acatttcaca 167160
gcatactcca ggaagtcatt tctccccagc cagactcaac agtctttgaa ggcttctaaa 167220
gtccagctgg gaggtagtgt tgagcctcta gcatgtctat tcatagacta ctagatccca 167280
tgagagctgc cattacaatt gctggagtac attttttcac ttcctatcac ctaaataaac 167340
ttcacccact gtgtgggttt gctaatccct tcctcatcct tgctgtatcc accaccctgt 167400
cttgtttcct tagcaactag acactgctga gggcagggca gaaggctaaa agggagcacc 167460
agtaagtgga atgagtgagt ggtggcttgg tgggctgcag aggggttagt tctcacgttg 167520
cctttttgag tattccccat cattttctct tctagtgcgc aagtgcaggg tcctcacatc 167580
tatccacact gtccacacag agagaacaca tttttaaaag ctagcccaaa gagagaacaa 167640
agagctgagg ataactattc ctaacccagg atgtctgcct tacattactt tttaggtact 167700
ttgcatttgt ttgctgctac tatcattgtt tgtttactat attttaggag ttcgaacaat 167760
cccaggcacc attcagacag aaagtggcaa atgtcatcta aaagggcagg gcttaacatt 167820
cccgtggcag tgtgtgcttc cccagtcaga gagagcactt tcttgctttt actgttttct 167880
aactcgagat ttcccccgct tttctggagc tttttttttt ttgttgttta gcttctcatc 167940
aagaaagtat aagttgtagg ctgcgggagt gtctgtgggg atgcgtttgt tttgtttttg 168000
agacagagtt tggctattta gagaaggcta gctttgaact cccagagacc cacctgcttg 168060
tctcaagtgc tggcactgaa agtatgtgtc cacatacctg gcctcgtgta ctaatttttt 168120
gataattaca aaaaagggca agaaaaaaag aaagaaagaa aatttctttc ttcagccatt 168180
cattctgtag cctgttgtgt ccaacactga tctaggcatt cttttggggt acttgagcag 168240
aaagactaga ctgtgtactt tctagctggg ctcttcacca gcaggtgcac atttcagtat 168300
ttatttggcc acttgaaaat ctcactgttg attttgtgat aaaaaaaaaa aacaaaaccc 168360
aggaacttat ttgtaaaacg attattcctg gtgtttatct gactcacctt atcatctgtg 168420
tttaaagatt ggtggggtac actctgagct atttgtactt ggcaagatcc ccaactctga 168480
gagcaaggtt ttagctggct agttttcctc cttcagcctc tgccaagtgc ttggtcctct 168540
agagaataat atgtaccttt tgtccccaca tattaaatac aaataaagag aagaacatgt 168600
catcttgagg cattggaagc tattaaggct atctcaggca atctggacaa ctctacgcct 168660
tggtcacata gtggcttctt aatatgtacc atggctcact caagaaaaat ggagtggtga 168720
ccaacttcag cctctgagtt ttgagatgga gactctgaga tagctgtcaa tattttgtaa 168780
aactgcttcc taacatcccg tacccctttc tgtatgtata tctgcatgca catgcacaca 168840
tatgggtata gagcccgcac tggccaaaag atgagagcag atctccctgg atccagaatt 168900
atatatggtt gtgagcttcc ctatattgct gctgagagcc aatccagttc tctggaagag 168960
caatactcac tctcaactgc tcagtcgcct ctacaaacca actgtttttt gtttgtttgt 169020
ttgtttgttt gtttgtctgt ttggtttggt ttggtttctc ttagacaggg tctctgactg 169080
ggaccgaggc ttgctgagta gggtaggcta tttgaccagc agccctcagg aatgcaagta 169140
ttttcctcaa catctgattt cctctttcct ttctccctcc ctccctccct ccctccctcc 169200
ctccctccct ccctcccttc cttaatttct tcctttcttc tttctttctt cctccttccc 169260
cctctcttcc cctctctctc tttctttttt tccattgccg acatgaagaa gtagagatga 169320
gcatgaccaa ggtcagtttc tgcttttcct gtgacaaggg ttctccccag tcaaccctgg 169380
tctgcccaca gaattcttat cccactgaaa ggaatagaca tttccctaca tgaagagttg 169440
taaagtggtg gttggtccca ttgcatgcac agagagtgag agacgggtaa cctgtgagac 169500
acctcctaca taaaaagagt tccagtgatc ttcaaagtgt ttgtcactca cccagaaaaa 169560
ctccagctcc tcactaccaa gcctaggaaa ggaagacaga aatacctaga gaggaattcc 169620
aatcacctca agaaaaatgg agtagtgacc agcttcagcc tctgagtttt gagatggaga 169680
ctctgagaga gctgtcaata ttttgtaaaa ccgtttccca ctcgatagca ttcccagagt 169740
gaaggttttt ctctcctcag ccatgagcta ggcttctgga tttctacatc ctgtttcatt 169800
tgtgttcttc ctcctatatt taagtgtaag cttgaatgag cgtctcagtt cacttcccac 169860
aatacgagaa tttcccaaac aaggagggca caccaaactc atgttagcag tgcctcttca 169920
ggtgttgccc atttttctcc ttcaaaagtc cccaagcctc ccaggtacta ctttgccagt 169980
tcaggttgtt caggggaggt acaccaagtg ctgattccca ctgagctcct actgacccta 170040
ttcagtattg tgccacagtt tacccttctc ttctcttctc ttctcttctc ttctcttctc 170100
ttctcttctc ttctcttctc ttctcttctc ttctcttctc ttctcttctc tcctctcctc 170160
tcctctcctc tcctctcctc tcctctcctc tcctctcctc tcctctcctc tcctctcctc 170220
tcctctcctc tcctttcccc tcccctcccc tccccctccc ctcccctccc ctccccctcc 170280
cctcccctcc cctcccctcc cctcccctcc cctcccctcc cctcccctcc cctccttttc 170340
ttttcttttc ttttcttttc ttttcttttc ttttcttttc ttttcttttc ttttcttttc 170400
ttttcttttc tttgtgatag gcttgggaag cttcccctgc aggactgtgg agctcttgtg 170460
ttcacatttg tgccttttgg aaagatgctt cagcggctgg acccgaggca agagtttgtc 170520
ttcaaaatgc tgccattgcc tctgtcagtt ttcatctgcc tgtaaacttt ttttttttct 170580
ttttgccaaa tctcctgaag caacttgacc tcaaggtttt ttttttttaa ttccctcaac 170640
tctttcttta ttctttgttc cattttcact atcttttttt tcttattagt taagagaaac 170700
caaagaattg attcacctgc tcattagttt tctcgaatat tcccctgtga ctaaagtaaa 170760
actaggctac acccctaaga gaaagatgcc tcttagggct cctgtcatct tcctattgtc 170820
ttgactggtg tgcatacaaa gtttgaacta tgaaactagg gcatggctga ttttggctcc 170880
agtgtttact tgtgaaccag tctattcact attgacctag ctttcagatt ccacagccct 170940
tctagcttcc ctaacataaa aacataagca ttatatgtat ttaggaagta tcatgttgtg 171000
ttccaataat atttatgcag tttgacctca gttgtgccct taatccttgt agtacctgtt 171060
ttagttaggg ttttactgct gtgaacaggc accatgacca agtcaactca taaaaacaac 171120
atttagtttg agctggctta taaattcaga ggttcccacc aatgtcatca aggtgggaac 171180
acgatagtgt tcaggccgat atggtgcaag aggagctgag agttgtacat tatcatagga 171240
aggctgctag cagaatagtg acttccgggc agctaggatg aagatcttaa agcccacacc 171300
cacaagagca cacctactcc aacaggacca caccttctaa tagtgccact ccctgggcca 171360
agcatattca aagcatcaca gtatcttaat tagaaaagtg ggagctatcc cttgttcatc 171420
tgtcttagtt gtcttgactg ctataacaaa acacctcaaa ctcattcatt cacaaag 171477
<210> 6
<211> 123
<212> DNA
<213> 小家鼠(Mus musculus)
<400> 6
atggggaccc gggcaagcag catcaccgcc ctcgcctctt gcagccgcac cgccggccaa 60
gtcggagcca cgatggtcgc cggctctctt ctcctgcttg gattcctcag caccatcaca 120
gct 123
<210> 7
<211> 96
<212> DNA
<213> 小家鼠(Mus musculus)
<400> 7
tggtacattc tggtgccaag tgtggccatt cccctggcta tcgccttcct cttcttcttc 60
atctgtgtgt gccgcaataa ccagaagtct tcatca 96
<210> 8
<211> 3075
<212> DNA
<213> 大肠杆菌(Escherichia coli)
<400> 8
ggtaccgatt taaatgatcc agtggtcctg cagaggagag attgggagaa tcccggtgtg 60
acacagctga acagactagc cgcccaccct ccctttgctt cttggagaaa cagtgaggaa 120
gctaggacag acagaccaag ccagcaactc agatctttga acggggagtg gagatttgcc 180
tggtttccgg caccagaagc ggtgccggaa agctggctgg agtgcgatct tcctgaggcc 240
gatactgtcg tcgtcccctc aaactggcag atgcacggtt acgatgcgcc catctacacc 300
aacgtgacct atcccattac ggtcaatccg ccgtttgttc ccacggagaa tccgacgggt 360
tgttactcgc tcacatttaa tgttgatgaa agctggctac aggaaggcca gacgcgaatt 420
atttttgatg gcgttaactc ggcgtttcat ctgtggtgca acgggcgctg ggtcggttac 480
ggccaggaca gtcgtttgcc gtctgaattt gacctgagcg catttttacg cgccggagaa 540
aaccgcctcg cggtgatggt gctgcgctgg agtgacggca gttatctgga agatcaggat 600
atgtggcgga tgagcggcat tttccgtgac gtctcgttgc tgcataaacc gactacacaa 660
atcagcgatt tccatgttgc cactcgcttt aatgatgatt tcagccgcgc tgtactggag 720
gctgaagttc agatgtgcgg cgagttgcgt gactacctac gggtaacagt ttctttatgg 780
cagggtgaaa cgcaggtcgc cagcggcacc gcgcctttcg gcggtgaaat tatcgatgag 840
cgtggtggtt atgccgatcg cgtcacacta cgtctgaacg tcgaaaaccc gaaactgtgg 900
agcgccgaaa tcccgaatct ctatcgtgcg gtggttgaac tgcacaccgc cgacggcacg 960
ctgattgaag cagaagcctg cgatgtcggt ttccgcgagg tgcggattga aaatggtctg 1020
ctgctgctga acggcaagcc gttgctgatt cgaggcgtta accgtcacga gcatcatcct 1080
ctgcatggtc aggtcatgga tgagcagacg atggtgcagg atatcctgct gatgaagcag 1140
aacaacttta acgccgtgcg ctgttcgcat tatccgaacc atccgctgtg gtacacgctg 1200
tgcgaccgct acggcctgta tgtggtggat gaagccaata ttgaaaccca cggcatggtg 1260
ccaatgaatc gtctgaccga tgatccgcgc tggctaccgg cgatgagcga acgcgtaacg 1320
cgaatggtgc agcgcgatcg taatcacccg agtgtgatca tctggtcgct ggggaatgaa 1380
tcaggccacg gcgctaatca cgacgcgctg tatcgctgga tcaaatctgt cgatccttcc 1440
cgcccggtgc agtatgaagg cggcggagcc gacaccacgg ccaccgatat tatttgcccg 1500
atgtacgcgc gcgtggatga agaccagccc ttcccggctg tgccgaaatg gtccatcaaa 1560
aaatggcttt cgctacctgg agagacgcgc ccgctgatcc tttgcgaata cgcccacgcg 1620
atgggtaaca gtcttggcgg tttcgctaaa tactggcagg cgtttcgtca gtatccccgt 1680
ttacagggcg gcttcgtctg ggactgggtg gatcagtcgc tgattaaata tgatgaaaac 1740
ggcaacccgt ggtcggctta cggcggtgat tttggcgata cgccgaacga tcgccagttc 1800
tgtatgaacg gtctggtctt tgccgaccgc acgccgcatc cagcgctgac ggaagcaaaa 1860
caccagcagc agtttttcca gttccgttta tccgggcaaa ccatcgaagt gaccagcgaa 1920
tacctgttcc gtcatagcga taacgagctc ctgcactgga tggtggcgct ggatggtaag 1980
ccgctggcaa gcggtgaagt gcctctggat gtcgctccac aaggtaaaca gttgattgaa 2040
ctgcctgaac taccgcagcc ggagagcgcc gggcaactct ggctcacagt acgcgtagtg 2100
caaccgaacg cgaccgcatg gtcagaagcc gggcacatca gcgcctggca gcagtggcgt 2160
ctggcggaaa acctcagtgt gacgctcccc gccgcgtccc acgccatccc gcatctgacc 2220
accagcgaaa tggatttttg catcgagctg ggtaataagc gttggcaatt taaccgccag 2280
tcaggctttc tttcacagat gtggattggc gataaaaaac aactgctgac gccgctgcgc 2340
gatcagttca cccgtgcacc gctggataac gacattggcg taagtgaagc gacccgcatt 2400
gaccctaacg cctgggtcga acgctggaag gcggcgggcc attaccaggc cgaagcagcg 2460
ttgttgcagt gcacggcaga tacacttgct gatgcggtgc tgattacgac cgctcacgcg 2520
tggcagcatc aggggaaaac cttatttatc agccggaaaa cctaccggat tgatggtagt 2580
ggtcaaatgg cgattaccgt tgatgttgaa gtggcgagcg atacaccgca tccggcgcgg 2640
attggcctga actgccagct ggcgcaggta gcagagcggg taaactggct cggattaggg 2700
ccgcaagaaa actatcccga ccgccttact gccgcctgtt ttgaccgctg ggatctgcca 2760
ttgtcagaca tgtatacccc gtacgtcttc ccgagcgaaa acggtctgcg ctgcgggacg 2820
cgcgaattga attatggccc acaccagtgg cgcggcgact tccagttcaa catcagccgc 2880
tacagtcaac agcaactgat ggaaaccagc catcgccatc tgctgcacgc ggaagaaggc 2940
acatggctga atatcgacgg tttccatatg gggattggtg gcgacgactc ctggagcccg 3000
tcagtatcgg cggaattcca gctgagcgcc ggtcgctacc attaccagtt ggtctggtgt 3060
caaaaataat aataa 3075
<210> 9
<211> 249
<212> DNA
<213> 人工()
<220>
<223> 合成
<400> 9
gtaatgatca taatcagcca tatcacatct gtagaggttt tacttgcttt aaaaaacctc 60
ccacacctcc ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt taacttgttt 120
attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca 180
tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc 240
tggatcccc 249
<210> 10
<211> 34
<212> DNA
<213> P1噬菌体()
<400> 10
ataacttcgt ataatgtatg ctatacgaag ttat 34
<210> 11
<211> 1213
<212> DNA
<213> 智人(Homo sapiens)
<400> 11
ggcctccgcg ccgggttttg gcgcctcccg cgggcgcccc cctcctcacg gcgagcgctg 60
ccacgtcaga cgaagggcgc agcgagcgtc ctgatccttc cgcccggacg ctcaggacag 120
cggcccgctg ctcataagac tcggccttag aaccccagta tcagcagaag gacattttag 180
gacgggactt gggtgactct agggcactgg ttttctttcc agagagcgga acaggcgagg 240
aaaagtagtc ccttctcggc gattctgcgg agggatctcc gtggggcggt gaacgccgat 300
gattatataa ggacgcgccg ggtgtggcac agctagttcc gtcgcagccg ggatttgggt 360
cgcggttctt gtttgtggat cgctgtgatc gtcacttggt gagtagcggg ctgctgggct 420
ggccggggct ttcgtggccg ccgggccgct cggtgggacg gaagcgtgtg gagagaccgc 480
caagggctgt agtctgggtc cgcgagcaag gttgccctga actgggggtt ggggggagcg 540
cagcaaaatg gcggctgttc ccgagtcttg aatggaagac gcttgtgagg cgggctgtga 600
ggtcgttgaa acaaggtggg gggcatggtg ggcggcaaga acccaaggtc ttgaggcctt 660
cgctaatgcg ggaaagctct tattcgggtg agatgggctg gggcaccatc tggggaccct 720
gacgtgaagt ttgtcactga ctggagaact cggtttgtcg tctgttgcgg gggcggcagt 780
tatggcggtg ccgttgggca gtgcacccgt acctttggga gcgcgcgccc tcgtcgtgtc 840
gtgacgtcac ccgttctgtt ggcttataat gcagggtggg gccacctgcc ggtaggtgtg 900
cggtaggctt ttctccgtcg caggacgcag ggttcgggcc tagggtaggc tctcctgaat 960
cgacaggcgc cggacctctg gtgaggggag ggataagtga ggcgtcagtt tctttggtcg 1020
gttttatgta cctatcttct taagtagctg aagctccggt tttgaactat gcgctcgggg 1080
ttggcgagtg tgttttgtga agttttttag gcaccttttg aaatgtaatc atttgggtca 1140
atatgtaatt ttcagtgtta gactagtaaa ttgtccgcta aattctggcc gtttttggct 1200
tttttgttag acg 1213
<210> 12
<211> 804
<212> DNA
<213> 大肠杆菌(Escherichia coli)
<400> 12
atgggatcgg ccattgaaca agatggattg cacgcaggtt ctccggccgc ttgggtggag 60
aggctattcg gctatgactg ggcacaacag acaatcggct gctctgatgc cgccgtgttc 120
cggctgtcag cgcaggggcg cccggttctt tttgtcaaga ccgacctgtc cggtgccctg 180
aatgaactgc aggacgaggc agcgcggcta tcgtggctgg ccacgacggg cgttccttgc 240
gcagctgtgc tcgacgttgt cactgaagcg ggaagggact ggctgctatt gggcgaagtg 300
ccggggcagg atctcctgtc atctcacctt gctcctgccg agaaagtatc catcatggct 360
gatgcaatgc ggcggctgca tacgcttgat ccggctacct gcccattcga ccaccaagcg 420
aaacatcgca tcgagcgagc acgtactcgg atggaagccg gtcttgtcga tcaggatgat 480
ctggacgaag agcatcaggg gctcgcgcca gccgaactgt tcgccaggct caaggcgcgc 540
atgcccgacg gcgatgatct cgtcgtgacc catggcgatg cctgcttgcc gaatatcatg 600
gtggaaaatg gccgcttttc tggattcatc gactgtggcc ggctgggtgt ggcggaccgc 660
tatcaggaca tagcgttggc tacccgtgat attgctgaag agcttggcgg cgaatgggct 720
gaccgcttcc tcgtgcttta cggtatcgcc gctcccgatt cgcagcgcat cgccttctat 780
cgccttcttg acgagttctt ctga 804
<210> 13
<211> 477
<212> DNA
<213> 人工()
<220>
<223> 合成
<400> 13
gctgtaagtc tgcagaaatt gatgatctat taaacaataa agatgtccac taaaatggaa 60
gtttttcctg tcatactttg ttaagaaggg tgagaacaga gtacctacat tttgaatgga 120
aggattggag ctacgggggt gggggtgggg tgggattaga taaatgcctg ctctttactg 180
aaggctcttt actattgctt tatgataatg tttcatagtt ggatatcata atttaaacaa 240
gcaaaaccaa attaagggcc agctcattcc tcccactcat gatctataga tctatagatc 300
tctcgtggga tcattgtttt tctcttgatt cccactttgt ggttctaagt actgtggttt 360
ccaaatgtgt cagtttcata gcctgaagaa cgagatcagc agcctctgtt ccacatacac 420
ttcattctca gtattgtttt gccaagttct aattccatca gacctcgacc tgcagcc 477
<210> 14
<211> 3626
<212> DNA
<213> 小家鼠(Mus musculus)
<220>
<221> CDS
<222> (443)..(2407)
<220>
<221> 信号肽
<222> (443)..(565)
<220>
<221> 成熟肽
<222> (566)..(2407)
<400> 14
gtgtccccga gctgagtggc catccgactc agtccctcgc cggccggtct aggcagcgga 60
ggaggcgagt gcttgatagt ggctggaagc ttcgctatgg gaagtcgctc tttagcactg 120
tcgcggctag ccctgctctc tggttctccg cagccgctgt cgttggagag caccgggagg 180
cgcgggttgc gagcgcgcct gcttctcacc gcccgggcgc cagcgcccct gggcaggtgc 240
tgagcgcctt tcggagcctc ccctgctgcc tccctcttcc gcctgggtgc ctggctgctg 300
cagtgcacat gggctgctgg aggtagatgg gctcaccgcc cgtgaggcgg cggtggatgc 360
ggcgctgggc agaaacagcc accaattcca gctgccgtgg ggccgagcgc cccgggcgcc 420
gctgcgagcc ccgagctcgg cc atg ggg acc cgg gca agc agc atc acc gcc 472
Met Gly Thr Arg Ala Ser Ser Ile Thr Ala
1 5 10
ctc gcc tct tgc agc cgc acc gcc ggc caa gtc gga gcc acg atg gtc 520
Leu Ala Ser Cys Ser Arg Thr Ala Gly Gln Val Gly Ala Thr Met Val
15 20 25
gcc ggc tct ctt ctc ctg ctt gga ttc ctc agc acc atc aca gct caa 568
Ala Gly Ser Leu Leu Leu Leu Gly Phe Leu Ser Thr Ile Thr Ala Gln
30 35 40
cca gaa caa aag act ctg agt ctc cct ggc acc tac cgc cat gtt gac 616
Pro Glu Gln Lys Thr Leu Ser Leu Pro Gly Thr Tyr Arg His Val Asp
45 50 55
cgt acc act ggc cag gtg cta acc tgc gac aag tgc cca gca gga acg 664
Arg Thr Thr Gly Gln Val Leu Thr Cys Asp Lys Cys Pro Ala Gly Thr
60 65 70
tac gtc tcc gag cac tgt acc aac atg agc ctg cga gtc tgc agc agc 712
Tyr Val Ser Glu His Cys Thr Asn Met Ser Leu Arg Val Cys Ser Ser
75 80 85 90
tgc ccc gcg ggg acc ttt acc agg cac gag aac ggc ata gag aga tgc 760
Cys Pro Ala Gly Thr Phe Thr Arg His Glu Asn Gly Ile Glu Arg Cys
95 100 105
cat gac tgt agt cag cca tgt cca tgg ccg atg att gag aga tta cct 808
His Asp Cys Ser Gln Pro Cys Pro Trp Pro Met Ile Glu Arg Leu Pro
110 115 120
tgt gct gcc ttg act gac cga gag tgc atc tgc cca cct gga atg tat 856
Cys Ala Ala Leu Thr Asp Arg Glu Cys Ile Cys Pro Pro Gly Met Tyr
125 130 135
cag tct aat ggt acc tgc gct ccc cat aca gtg tgc ccc gtg ggc tgg 904
Gln Ser Asn Gly Thr Cys Ala Pro His Thr Val Cys Pro Val Gly Trp
140 145 150
ggt gtg cgg aag aaa ggg aca gag aat gaa gat gtg cgc tgt aag cag 952
Gly Val Arg Lys Lys Gly Thr Glu Asn Glu Asp Val Arg Cys Lys Gln
155 160 165 170
tgc gct cgg ggt acc ttc tct gac gtg cct tcc agt gtg atg aag tgt 1000
Cys Ala Arg Gly Thr Phe Ser Asp Val Pro Ser Ser Val Met Lys Cys
175 180 185
aaa gct cac acg gac tgt ctg ggt cag aac ctg gag gtg gtc aag cca 1048
Lys Ala His Thr Asp Cys Leu Gly Gln Asn Leu Glu Val Val Lys Pro
190 195 200
ggg acc aag gag aca gac aac gtc tgt ggc atg cgc ctg ttc ttc tcc 1096
Gly Thr Lys Glu Thr Asp Asn Val Cys Gly Met Arg Leu Phe Phe Ser
205 210 215
agc aca aac cca cct tcc tct ggc aca gtt acc ttt tct cac cct gag 1144
Ser Thr Asn Pro Pro Ser Ser Gly Thr Val Thr Phe Ser His Pro Glu
220 225 230
cat atg gaa tcc cac gat gtc cct tcc tcc acc tat gag ccc caa ggc 1192
His Met Glu Ser His Asp Val Pro Ser Ser Thr Tyr Glu Pro Gln Gly
235 240 245 250
atg aac tca aca gat tcc aac tct act gcc tct gtt aga act aag gta 1240
Met Asn Ser Thr Asp Ser Asn Ser Thr Ala Ser Val Arg Thr Lys Val
255 260 265
cca agt ggc atc gag gaa ggg aca gtg cct gac aat acg agc tca acc 1288
Pro Ser Gly Ile Glu Glu Gly Thr Val Pro Asp Asn Thr Ser Ser Thr
270 275 280
agt ggg aag gaa ggc act aat agg acc ctg cca aac cca cca caa gtt 1336
Ser Gly Lys Glu Gly Thr Asn Arg Thr Leu Pro Asn Pro Pro Gln Val
285 290 295
acc cac cag caa gcc ccc cac cac aga cac att ctg aag ctg ctg cca 1384
Thr His Gln Gln Ala Pro His His Arg His Ile Leu Lys Leu Leu Pro
300 305 310
tcg tcc atg gag gcc acg ggt gag aag tcc agc aca gcc atc aag gcc 1432
Ser Ser Met Glu Ala Thr Gly Glu Lys Ser Ser Thr Ala Ile Lys Ala
315 320 325 330
ccc aag agg ggt cac ccc aga cag aac gct cac aag cat ttc gac atc 1480
Pro Lys Arg Gly His Pro Arg Gln Asn Ala His Lys His Phe Asp Ile
335 340 345
aac gag cac ttg cct tgg atg atc gtc ctc ttc ctt ctg ctg gtc ctg 1528
Asn Glu His Leu Pro Trp Met Ile Val Leu Phe Leu Leu Leu Val Leu
350 355 360
gtg ctg ata gtg gtg tgc agt atc cga aag agc tcc agg act ctc aaa 1576
Val Leu Ile Val Val Cys Ser Ile Arg Lys Ser Ser Arg Thr Leu Lys
365 370 375
aag ggg ccc cgg cag gat ccc agc gcc ata gtg gaa aag gcg ggg ctg 1624
Lys Gly Pro Arg Gln Asp Pro Ser Ala Ile Val Glu Lys Ala Gly Leu
380 385 390
aag aag tcc ctg act ccc acc cag aac cgg gag aaa tgg atc tac tac 1672
Lys Lys Ser Leu Thr Pro Thr Gln Asn Arg Glu Lys Trp Ile Tyr Tyr
395 400 405 410
cgc aac ggc cat ggt att gac atc ttg aag ctt gta gca gcc cag gtg 1720
Arg Asn Gly His Gly Ile Asp Ile Leu Lys Leu Val Ala Ala Gln Val
415 420 425
gga agc cag tgg aag gac atc tat cag ttt ctt tgc aac gcc agc gag 1768
Gly Ser Gln Trp Lys Asp Ile Tyr Gln Phe Leu Cys Asn Ala Ser Glu
430 435 440
agg gag gtg gcg gcc ttc tcc aat gga tac act gca gat cat gaa cgg 1816
Arg Glu Val Ala Ala Phe Ser Asn Gly Tyr Thr Ala Asp His Glu Arg
445 450 455
gcc tac gcg gct ctg cag cac tgg acc atc cgt ggc cct gag gcc agc 1864
Ala Tyr Ala Ala Leu Gln His Trp Thr Ile Arg Gly Pro Glu Ala Ser
460 465 470
ctt gcc cag ctc att agc gcc ttg cgc cag cac cga cgc aat gat gtt 1912
Leu Ala Gln Leu Ile Ser Ala Leu Arg Gln His Arg Arg Asn Asp Val
475 480 485 490
gtg gag aag att cgt ggg ctg atg gaa gac acc acg cag ttg gaa aca 1960
Val Glu Lys Ile Arg Gly Leu Met Glu Asp Thr Thr Gln Leu Glu Thr
495 500 505
gac aaa ctg gct ctc ccc atg agc ccc agt ccg ctt agc ccg agc ccc 2008
Asp Lys Leu Ala Leu Pro Met Ser Pro Ser Pro Leu Ser Pro Ser Pro
510 515 520
atg ccc agt cct aac gtg aaa ctt gag aat tcc act ctc ctg aca gtg 2056
Met Pro Ser Pro Asn Val Lys Leu Glu Asn Ser Thr Leu Leu Thr Val
525 530 535
gag ccc tca ccg ctg gac aag aac aag tgc ttc ttc gtg gac gag tca 2104
Glu Pro Ser Pro Leu Asp Lys Asn Lys Cys Phe Phe Val Asp Glu Ser
540 545 550
gag ccc ctt ctg cga tgc gac tcc aca tcc agt ggc tct tca gca ctg 2152
Glu Pro Leu Leu Arg Cys Asp Ser Thr Ser Ser Gly Ser Ser Ala Leu
555 560 565 570
agc aga aac ggc tcc ttt att acc aaa gaa aag aag gac aca gtg ttg 2200
Ser Arg Asn Gly Ser Phe Ile Thr Lys Glu Lys Lys Asp Thr Val Leu
575 580 585
cgg cag gtc cgc ctg gac ccc tgt gac ttg cag ccc atc ttt gat gac 2248
Arg Gln Val Arg Leu Asp Pro Cys Asp Leu Gln Pro Ile Phe Asp Asp
590 595 600
atg ctg cat atc ctg aac ccc gag gag ctg cgg gtg att gaa gag att 2296
Met Leu His Ile Leu Asn Pro Glu Glu Leu Arg Val Ile Glu Glu Ile
605 610 615
ccc cag gct gag gac aaa ctg gac cgc ctc ttc gag atc att ggg gtc 2344
Pro Gln Ala Glu Asp Lys Leu Asp Arg Leu Phe Glu Ile Ile Gly Val
620 625 630
aag agc caa gaa gcc agc cag acc ctc ttg gac tct gtg tac agt cat 2392
Lys Ser Gln Glu Ala Ser Gln Thr Leu Leu Asp Ser Val Tyr Ser His
635 640 645 650
ctt cct gac cta ttg tagaacacag gggcactgca ttctgggaat caacctactg 2447
Leu Pro Asp Leu Leu
655
gcggggtgat ttcatttcgt ttctgacttt tgtgttttgg tgtgtatgta tgtgtttaac 2507
agagtgtatg gccggtgagt ttgggttctt tctttctttc tttctttctt tctttctttc 2567
tttctttctt tctttctttc tttctttctt tcttccttcc tgaaagtgaa tgtataaagc 2627
ctttacaatg tataactgtt ggaaaatgcc caccactaaa ttttttttta agttccacat 2687
attctccatt tttgccttct tatatatatc ttcaacacta ttctgtgcac tttaaaaact 2747
taacataaac gcagtgtgac ttctcccata tgctgggtcc cgagactctc aacttcttaa 2807
aaacctaatg gcatcttgtg actcctagaa gtagacataa gtctttcaac cttcacacct 2867
actctttctg ttttaattat tattgctatt tgtcttattg tttgtgcttt acaagcgttc 2927
ttgaggacgg agggaatcta cgaccctgtt gatgactgta actctattcg actttgagtt 2987
gtcttcttca tgtcttgtta tatagttcat attcatggct gaaacttgac catactccct 3047
agcgctgatt gtatggtttt cgtctggaca ccgtacactg cctgataact tgtgcacctc 3107
ttaacgctac tatgctctgg gctggagaat gaaatcttta agtcaccagg acttgctgtt 3167
tcagtggctt gacacctggg ccaccaaaga actcgatctt catcttttag ggacacctct 3227
gctgcacctt ggaaagccaa ccttaagtgc cagtggcact ttatgcccag ctttgctttg 3287
aaagatatct ttcttgtttt ttttatcctt ctctttctct ctttttttta aaaatacaca 3347
tagtcaatag gtccagtctg ccctcaaggc cttgctgggt tttcttcatc atccaatcac 3407
tttcattaaa aatggctgca gctgtaagaa ctcttgtctg ataaattttc aactatgctc 3467
tcatttatct acctgccctc tgatgctcag tcgtcagact ctaatgcaaa ggtggacgtc 3527
ggctgccttt gcgtgggcgg gcttagtggt gaggaactga tatcagaaaa aaaatgcctt 3587
caagtatact aatttattaa taaatattag gtgtttgtt 3626
<210> 15
<211> 655
<212> PRT
<213> 小家鼠(Mus musculus)
<400> 15
Met Gly Thr Arg Ala Ser Ser Ile Thr Ala Leu Ala Ser Cys Ser Arg
1 5 10 15
Thr Ala Gly Gln Val Gly Ala Thr Met Val Ala Gly Ser Leu Leu Leu
20 25 30
Leu Gly Phe Leu Ser Thr Ile Thr Ala Gln Pro Glu Gln Lys Thr Leu
35 40 45
Ser Leu Pro Gly Thr Tyr Arg His Val Asp Arg Thr Thr Gly Gln Val
50 55 60
Leu Thr Cys Asp Lys Cys Pro Ala Gly Thr Tyr Val Ser Glu His Cys
65 70 75 80
Thr Asn Met Ser Leu Arg Val Cys Ser Ser Cys Pro Ala Gly Thr Phe
85 90 95
Thr Arg His Glu Asn Gly Ile Glu Arg Cys His Asp Cys Ser Gln Pro
100 105 110
Cys Pro Trp Pro Met Ile Glu Arg Leu Pro Cys Ala Ala Leu Thr Asp
115 120 125
Arg Glu Cys Ile Cys Pro Pro Gly Met Tyr Gln Ser Asn Gly Thr Cys
130 135 140
Ala Pro His Thr Val Cys Pro Val Gly Trp Gly Val Arg Lys Lys Gly
145 150 155 160
Thr Glu Asn Glu Asp Val Arg Cys Lys Gln Cys Ala Arg Gly Thr Phe
165 170 175
Ser Asp Val Pro Ser Ser Val Met Lys Cys Lys Ala His Thr Asp Cys
180 185 190
Leu Gly Gln Asn Leu Glu Val Val Lys Pro Gly Thr Lys Glu Thr Asp
195 200 205
Asn Val Cys Gly Met Arg Leu Phe Phe Ser Ser Thr Asn Pro Pro Ser
210 215 220
Ser Gly Thr Val Thr Phe Ser His Pro Glu His Met Glu Ser His Asp
225 230 235 240
Val Pro Ser Ser Thr Tyr Glu Pro Gln Gly Met Asn Ser Thr Asp Ser
245 250 255
Asn Ser Thr Ala Ser Val Arg Thr Lys Val Pro Ser Gly Ile Glu Glu
260 265 270
Gly Thr Val Pro Asp Asn Thr Ser Ser Thr Ser Gly Lys Glu Gly Thr
275 280 285
Asn Arg Thr Leu Pro Asn Pro Pro Gln Val Thr His Gln Gln Ala Pro
290 295 300
His His Arg His Ile Leu Lys Leu Leu Pro Ser Ser Met Glu Ala Thr
305 310 315 320
Gly Glu Lys Ser Ser Thr Ala Ile Lys Ala Pro Lys Arg Gly His Pro
325 330 335
Arg Gln Asn Ala His Lys His Phe Asp Ile Asn Glu His Leu Pro Trp
340 345 350
Met Ile Val Leu Phe Leu Leu Leu Val Leu Val Leu Ile Val Val Cys
355 360 365
Ser Ile Arg Lys Ser Ser Arg Thr Leu Lys Lys Gly Pro Arg Gln Asp
370 375 380
Pro Ser Ala Ile Val Glu Lys Ala Gly Leu Lys Lys Ser Leu Thr Pro
385 390 395 400
Thr Gln Asn Arg Glu Lys Trp Ile Tyr Tyr Arg Asn Gly His Gly Ile
405 410 415
Asp Ile Leu Lys Leu Val Ala Ala Gln Val Gly Ser Gln Trp Lys Asp
420 425 430
Ile Tyr Gln Phe Leu Cys Asn Ala Ser Glu Arg Glu Val Ala Ala Phe
435 440 445
Ser Asn Gly Tyr Thr Ala Asp His Glu Arg Ala Tyr Ala Ala Leu Gln
450 455 460
His Trp Thr Ile Arg Gly Pro Glu Ala Ser Leu Ala Gln Leu Ile Ser
465 470 475 480
Ala Leu Arg Gln His Arg Arg Asn Asp Val Val Glu Lys Ile Arg Gly
485 490 495
Leu Met Glu Asp Thr Thr Gln Leu Glu Thr Asp Lys Leu Ala Leu Pro
500 505 510
Met Ser Pro Ser Pro Leu Ser Pro Ser Pro Met Pro Ser Pro Asn Val
515 520 525
Lys Leu Glu Asn Ser Thr Leu Leu Thr Val Glu Pro Ser Pro Leu Asp
530 535 540
Lys Asn Lys Cys Phe Phe Val Asp Glu Ser Glu Pro Leu Leu Arg Cys
545 550 555 560
Asp Ser Thr Ser Ser Gly Ser Ser Ala Leu Ser Arg Asn Gly Ser Phe
565 570 575
Ile Thr Lys Glu Lys Lys Asp Thr Val Leu Arg Gln Val Arg Leu Asp
580 585 590
Pro Cys Asp Leu Gln Pro Ile Phe Asp Asp Met Leu His Ile Leu Asn
595 600 605
Pro Glu Glu Leu Arg Val Ile Glu Glu Ile Pro Gln Ala Glu Asp Lys
610 615 620
Leu Asp Arg Leu Phe Glu Ile Ile Gly Val Lys Ser Gln Glu Ala Ser
625 630 635 640
Gln Thr Leu Leu Asp Ser Val Tyr Ser His Leu Pro Asp Leu Leu
645 650 655
<210> 16
<211> 168823
<212> DNA
<213> 人工()
<220>
<223> 合成
<400> 16
ggtgttcctt ggcaactcac tttttctttt taaaaattgt gtgtgtgtgc tgtgtgtgta 60
tgtgtgagtg ggtaagtagg tgtacagcag ccaggggagg atctcagatg tcttccccta 120
tcattctgcc ttgtgccttg tgcctttgag gcagaacatc ttggtgaacc cagagcttat 180
atatgtagac acacacacag atatataaac acattatatg tatataaata tatataatgt 240
gataccataa tatagatata tacacaagac acacacacat atatatgtaa tataatatat 300
gtaatttata tacacatatg tatatgaata tatatatata atatgctacc ataatataga 360
catatactag acacacatat atgtaatata tacaaatatg tatataaata tataatttat 420
gctatcataa tatatatacc ctagacatat atgtataata taacacatat atgtgatata 480
tgtgtgtgtg tgtatataca tatatatata tatatcacgc acacacacat acatacgtct 540
agggtagcaa ccaatcctag taatcctcct gttttcattc ccctcaatgg tctacaggca 600
tgtatgagac cacatatggc ttttatgggt gtatgtgtga tctaaactca gaccttcacg 660
tttgcataat aatcactgtt aactgctgag ccatctctcc ttctctcact ttcctttctt 720
tttgaaaaaa aattttttat acattatgtt tttattttat tttacttatt tttatttttt 780
taatattaga tttttttctt tatttacatt tcaaatgtta tcccctttcc tggtttcccc 840
tccaaaaacc cctatcccat ccccactccc cctgttcacc aacccaccca ctcgcttccc 900
tgtcctggca tgcccctaca ctggggcata tacattaggt tttgagcgaa ttccaggata 960
gccagggcta cacagagaaa ccttgtcttg aattaaaaaa aatttttttt ttaaattaga 1020
gttgctgcca tgagtatgag caacttaaga aaattatctc tcgccgggca gtggtggcac 1080
acgcctttaa tcccaacact tgggaggcag aggcaggtgg atttctgagt tcaaggtcag 1140
cctggtctac agagtgagtt ccaggacagc cagagctaca cagagaaacc ctataaaaaa 1200
ataacacaca cacaaaaaaa atcaaaaaca aaaacaaaca agagagagag agagagagag 1260
agagattctt tccctccaac ttctcccaga ccttccctac ctccattccc accaacttca 1320
tgtttttttt tctctctctc tctttctcaa aaccaaaaaa tgccaggaaa gcaacaaaaa 1380
ataagtagca agaaagtcag aacaaagaaa ttaaatacgt aagtaagtaa ataaaaatag 1440
aaaatcagca atattaaaaa aaaatcaagg actggagaga tggctcagca gttaagagca 1500
ctgattgctc ttccagaggt cctgagttca aatctcagca accacatagt ggctcacaaa 1560
catctgtaat gggatccgat gccctcttct ggtgtgtctg aagagagcta cagtgtactt 1620
acgtttaata aataaatctt taaaacaaga caacacaaaa atccaaaata aaatttcaaa 1680
gtgtaccaac acaaaacatg tagtctgttt tgtgttggtc aactactcct gggtatttag 1740
gcttccttgg agtgtggttg ctatacccag tgacactcag ttaagaaaag tgaatttccc 1800
tttcctggca gggatcaatt gcaagtagct ttttggttag gggtagaata ttatattcca 1860
ccttcctgtg ctggttccac ctgtaaatgt ctgtgcagag ctgtttatgt ttacgtctca 1920
ggcagagctc tgaggaagat attagtaagc aagacattcc ttggagagtg cttgggggat 1980
ccagcaactg tgaaaggaaa aagaaatatt aatcaaaggg ataaattaac cttcaataca 2040
gtttcagcaa aggcctctca tggtgctgtc cccagttgag gcaaggcaac agaccttttt 2100
cctcaccaaa cactcactgg tgtaggggca tggtatgacc tgtcatcagg cagggaacat 2160
tcaccacaca gagtggagag gagctgtggc catctcttca atcagagcag ggtgttggat 2220
ggacgttgcc agcctgtacc acccaccatt cacatcagct gctctgtgca cacagcacac 2280
tccaacccac agagaaggtt tgtttctgtt tttatttttg ctttttatta ttatctcatg 2340
taaaattatt atttatttta tttttgcttt ttttattatt atctcatgta acccaggttg 2400
gctttaaatt tgttatgtag tcaaggagga ctttgaactt cttccctcac ctctagagtg 2460
ctggggtcac aggcacgtat cactattcct gttcacctgg tacttggaat caaacccagg 2520
cttcatgaat aatagaccta aactcttcca aaccaagaag aaccacatct cacgagattt 2580
gacatgctgt gggttttttt ttttcctctc ccccctctgt ctctctcctc ttctgtccct 2640
ctttctccct cttctttatt tctttcattt ttatttttac ttttgaaaag aagctggctt 2700
caaaattctc catatggctg aggacgactt cagcctttaa tttctttttt tgtttgtttg 2760
tttgtttttc taggcagggt ctcactacac agccctggct gtccttgaac tcactatgca 2820
gactaggctg gcctcgaacc tggagatctg cttgcctctg cctcctcagt gctgaaattg 2880
aagacttgca ccaccaaggt atttttagtt aatcgtttga aaaatttata catgtttaca 2940
atgtattttg atcaaatcca acagaaatct tcctctcact tcttctcagt ccccctacat 3000
ctttcctacc ataatttctc tctttctctt ctttttattt ttgaaataac ccaccaagtc 3060
cagatagtac tgtctacaag tgcataaatg tagagccatc ggctaaagca tggccaggct 3120
actagtaatc ccactgaaca ttacacacgt tctttggtca aattaagcaa gcttaatttt 3180
ctgttagaca gggatagctc cctaaatcag actttgataa tatagcatga cacttaagag 3240
aaagtggggc ttgtagagcc tccaaaacct gcaagcctgg gggtttttta aggcttggga 3300
gacttccaga ggaattttga ttgcatagga acttggctag cagaacatct tatcttatca 3360
gggtgcattc aaggtgtgag tcaggctcca gagggtgggg agcaagtcgg attccagaaa 3420
cacacagtga gtgtttggtg aggaaaaagc acagtcaacc tgaattttgc agcagacaga 3480
aatgaacttc tgaccttata acaaaatggc ttccgtcctt aagatggcgt caggctggtc 3540
catcagtaac tacacccctg aagaaaagtt atttcctctc cctaactgtc accaattgcc 3600
agcaacttct cagctaggaa tagagcctca tgatttcctc tcccactcat actgggtgtt 3660
gactggcttg agtgccatgc cacgtcctga agacagcatt tcacagcatt tgtccctatc 3720
ctctggctcc tacggttctt ttgttccctc tgctgagatg taggtacccc gagccttgta 3780
gtagaagtga caggcatgtc ccatttatgg atgactactc aatggtcaca tactctcaga 3840
actgtggcca gttatgagtc tgtgttgact gctgcctact gcaaaaggag tcttctctgg 3900
gcaaaacagt agtaatctac atgtataaaa cacaaatgct tacaaggtag tttgatgggg 3960
gggggggact gtcaaacaac ccttgcacag gggtcaccta ataccatctg cacaggggat 4020
atttgtgcct tccctcagcc ttgagtaggc taaacaaacc catgatagtt ttacaaccta 4080
gctggagtct tctgacctca ccacatttgc aatttcctat agagctttga ggagtagact 4140
gcccactgag cttgctttgc aacataatct ggctgaaacg aaggatgggg tttgtgggct 4200
ttctcagtgc tgaaaattaa ctttgagcct tgatcagaaa cgtttgtctt tgcttcatcc 4260
ttctcttgca cccagttttt ttctcagttc caggcccccc cccgccccgc ccctttcagg 4320
tatacccagt ttgtccatgg ccactggaca gctacagata tttacattac gattcacaac 4380
agtagcaaaa ttagttatgg agtagcattg aaatagtttt atggttgggc atcaccataa 4440
cacgaggaac tgtcttaaag ggtcacagct ttaggaaggc tgagaaccac tgtcctgcag 4500
cctagctctc atgggtcctt gataaggttt gtagcaccag acatgaactt tttcctgtgg 4560
agcagccctc aaagacagtc agaaagagca gttggttatc ccaacaacca acatgtcact 4620
attatatcaa gggggctttc ctatagcgtg aatggtcctc agagggtaag tccatctttt 4680
ctccccacgt cgcagggata gcatttcctg gcaccatgaa agcaggccag tagaaaggaa 4740
gtttctaagg accttgtact tctgatcctc ctcctcgcat gtgttgggat tacaggcctg 4800
caccaccaca tccagtttat taggggctag gcatgtgcac agtaagccaa cactcaataa 4860
gcagaacgac actcagacct cagccccttc atttagtgtt agtgtgttgg tggttgttta 4920
ttattattat tattattatt aattcaccac acagcaattt atgtcctaca tgtcacattc 4980
atttttaaat tccctttact ttttccccta ctttgtttta gaatatatgt atatgtgtat 5040
gtgtatacac gcacacacac acatacatat atatgtgtat acacacatac atatatgtgt 5100
attcatgcat atacatatgt gaatatacac acatacacac gtatatatga gtatacacac 5160
atatacatat ataatatgtg cgcacacata tattttatat attagcattc cagcttaggg 5220
gcttcagtgt agctcattgg cacagctctt gtctagcgtt ccagttttat ttctactttt 5280
ggcttttaag tctatttgtt ctattgattt aaagcttaca gtacctcggt gggggcacac 5340
acctttaatc ctagcactct ggaggcaaag gcaggtggat ctccgagttt gaggccatcc 5400
tggtctacag atcgagttcc aggataaacc gaaagtagag aaaccatgtc tcagaaacca 5460
aaagctaaaa caaacagaaa agattcacaa caaatatttt taaatcatta caatatatta 5520
caatatcatt aatattacac ccctttaagg gtagtataag aatctttatg ttatgtgtct 5580
ataaaatggg ttgaggagct ggtgagatgg ttcagtggat gaaggagctt gttagcaagc 5640
ctgccaactt gagttcaatc cctaggaccc acgtgataaa aggagggagt agattctttg 5700
aagttgtcct ctgacctcca catgtatact atgtcacatg tgttcggcat aaaataaaca 5760
aaaacataga agggagccta ggagacagtg ccgttggtac aaagcctgct gcaagagcat 5820
gaagccctga gtttgagccc tagcactcgg tcttatgcat acagcacatg tctgtaatct 5880
cagcactggg gagacaaaag agtgagtggc cctggagttt gctgggctgc cagtcaagcc 5940
aaatcgacta gctccagata gggagtgggg cagagaaaga ctgagcccat ctcaatggtg 6000
ggcaatgatt gataaagaca tccagtcttg ccttctggct tcccataagt gcatccctca 6060
gtgatatact gttacctgga agagtaagcc aaccaagccc tttcctccct aactgatttt 6120
ggttggaaag gaggccattt ccatgaagct aggaattgac cttggatgga agatgctggc 6180
ggaagtttct ggtttagtcc aggtggcccc cgaagtgtgg gctacaccat ttcccagaaa 6240
cctctagtag gcatgcactc cagctaccca tgctggacac tcgttctttg atctctctcg 6300
tttactttct tattttcctt atattatttg ctcgtttatc cccagacatt cctgggactg 6360
tcttttacac aaattcttca catcccatga tgtctttccg gctctccgtc ttggaagaaa 6420
acacccaagt gactgactgt gaccaaacgg ttacatgcaa atgtatgaaa tctggggacg 6480
aatgcagtaa taaaaggtga cttaaagggg ctggagtgat ggttcagtgg ataagagcac 6540
tgactgcact tccagaggtc ctgagttcaa ttcccagcaa ccacatggtt cacaaccatc 6600
tataatggga cccgatgccc tcttgtggtg tttctgagga tagcaacagt gtactcatat 6660
aaataaatca atcttaaaag aaaataaaaa acatttcatt aaactcgata ataggtataa 6720
atgcgaactt aatggatgtt ctcagggaag ttgactgtaa cttgtaattt gttcagtgaa 6780
tagcaagcat ataacaacca gacggctaaa actaccacac cgctaccaca catgtttctt 6840
tacgtatcac atctgcattt ccccttgcct caagcatagt acttggaact ttgttcctca 6900
tattttatga ctgccttcat ttttttagaa aagagttgtt actattatta tatgtaagta 6960
cactgtagct gtctttagac acaccagaag agggcatcat gtggttgctg ggatttgaac 7020
tcaggatctc cagaagagca gtcagtgctc ttaactgctg agccattttt ctagctcaag 7080
tgcctttgtt ctttttctgg agtttctgga tctagacagt gtgccttaat tttgttcttc 7140
agtgatgttt ccagcctgca accgagcttc ccttcctcgg ctggaaaccc atctttgcct 7200
tctagattcc tgaagaggtt gaatttcatg tgctgactac aggtcccttc ttcaaaaccc 7260
attctgccct cagaatctat gaacccgatt taaaaaaaaa aaggattttt atttttatgg 7320
gtttggctat tttgcctgta ttcatatctg tgcaccacat gcatgaagtg cttgcagagg 7380
ccaaaagagg gcgccagata tcccggaact ggagttacag atggttgtgg gccagtgctc 7440
tggaaaaaca gtcagtgctt ttaaccccta agctatctca ccagccctca tcttctctta 7500
gaccgagtgc tagggctcaa actcagggct tcatgctctt gcagcaggct ttgtaccaac 7560
ggcactgtct cctaggctcc cttctatgtt tttgtttatt ttatgccgaa cacatgtgac 7620
atagtataca tgtggaggtc agaggtcaac ttcaaagaat ctactccctc cttttatcac 7680
gtgggtccta gggattgaga agtcatctgt gatttttgac ccagctgccc tacctcattt 7740
tgcagggaac agggatgggg atgggaatgg caaagggcag gacactgttc caccttccgc 7800
ctcaaggctg ttaacaaggt ggtttaatac tgaattgcca gcccagccca gcccagcctt 7860
tcactatttt cccggtattg tcaaacattt cctccacact acctatagaa tattcttact 7920
tatgtttaat gatctacttt agtgtttatt ttaagtacat actatgttcc gttccttgac 7980
ctcgctgtac tttgtttatt cgtaaatata cttacccacc tgttgtaata aaaatgtcct 8040
tctgtccttc cttcctttct tcctttcttc ctttcttcct tccttccttc cttccttcct 8100
tccttccttc cttccttcct tccttctttt ctcccttcct tctttcctcc cctccttcct 8160
tctttcctcc cttctttctt tcctcccttc cctccctcat ttctttaacg ttcaaccaat 8220
gtttctttct cacgtttcct ttccaaggtc agttccgagg gctggacaac cacactaagc 8280
tcagcggctc cgcacatcct gccctcgtgg agcccatgtt aaagagaggt tggtggagac 8340
acgcaatgga cactggagac aacgacttag cttagtaccc taaaagtgaa tggaggatat 8400
gcaaaaataa gatagagggg agagcaaagg aatttggcgt ccagcgttag tgtgtgtgta 8460
ggagtgcgta gtaaagagca gaagctcgtt acgtgtgcag cggatgtgag agtctcacag 8520
agggaacccc cagcgctaag ttcctgaggc ttggtgggtc aaagaacaaa ttaacctcag 8580
catagttacc cttccataag caacaaattc tccaggtcca ctaagcctcg tgatcagcag 8640
cctgtacagt cacttatgag gaacttttat agggagaaca ggatgtgatg gtgtatttaa 8700
acatatgtat ttaaagatgg ctcagtgaat aagggtgctt gttgcccaga cctgagttca 8760
atccttgggc tccacgtggg ggaaggagag aaccaactcc tgatcctcca catgaatgct 8820
gacatgagca tgcacataag caatacatga gtctaatttt aaaaaaggaa aaatacctct 8880
ggttaacata taataaattg ctattctttt agatggttgg attcctaata cacaccagca 8940
cagagtgaac gcactgggta atgtacaata gcaaggtgac ttacatcaaa ctacattaaa 9000
tgtttaaaac agtgaaaacc tgaaaagcta acatttttgt ccaatgtgaa aaaaaagtct 9060
tatttagtag catgatatac acagaggtaa aaatagatat cagaaagtcc cccacatatg 9120
ctaatcaatt ttgttcttaa tctttacata tccacttatt tttgtgatat ctttatttta 9180
tgcataaggg tgttttgcct gaatgtatgc ctttgtaaat acttgcatgc agtacccaca 9240
aaggccagaa gagggcgtga gatcccctgg aattgaagct actgatggtt gtgaaccacc 9300
acgttggtgt tggaaatctg acccaaatgc tctgcaagag tcgccagtgc tctgaaccat 9360
gtccaagtta tctctccagc attatatatc cacgtttgaa gtagaggtac attgggcttt 9420
tcatttttat agtggttact taaagcatag tctatgctgt ttttaagtga cagaatgttg 9480
ttcattgtat ttaaaaaata tagacaaaaa tttaaacact ttaaaaaata ttatttttct 9540
ttatgaagat acatgctttt aaggggttct gttggagaat ttcagtagcg ccaacttaaa 9600
acaaatactt tattagggct gtagaaatga cttagaggtt aatagtgtgc actgctcttg 9660
cagaggatcc gagtttggtc cctagcaccc atgtcagggg cttacaacac aacctcctgt 9720
aactgatgct gcaggggatc ccaccccctc ttctggcccc tctcatgcac aacacacatg 9780
aggcaggcac agactgatgc acatatatgt gaattaaacc ccaaataaaa tcgttttcaa 9840
aagtccaatg aatgtcttga caatgctttt ataatcaatt cattcatgac aggtggttcc 9900
ctgtgtttgt gatttctctt caagctgcgc atcaaagcaa cccctccttc tccctccttc 9960
cctccctcct cctcctcctc ttcctcgttc tcctccctct ctctgtgcat gtgtgcctgc 10020
ttacctgttt gcgcaccgca ggcgtgcagg tgcccacgga gtgattaatg aattctttgg 10080
aactgggtta caggcagttg tgggcgatgt agtgtaaatg ctgggaacca aactcgggtc 10140
ccttggaaga gcagcagtgc tcttcacaga tgagccatcc ctcaagtccc caagaacttg 10200
tttctcttgc tcagcttgca ctctccaaga cttaggaaag tgcttagtga ataagctggg 10260
gcacaaaaga tgcggttata agaaggtgac gtaggagcct ctggcaagcg atgcagatgc 10320
caattctcac ttgtgttccg gtccctctcg cttttgtcag ttttagaatg ttctaggctg 10380
ggtttggtgc tgtcgtagca cagagaggaa acagcatgaa ggacaaccag gccagagata 10440
gttgatggtc tgagcctttt gtttgctggc ttcactcgct ccgctgttct aaagcttcag 10500
tcaatgggtc tatgttgaac cagtttccgc tgttcactac aaagatgcaa ttggaagccg 10560
agggagggag ggagaagctc tggagagtat ggctcagtgg ttaagagcac tgactgctct 10620
tccaaaggtc ctgagttcaa atcccagcag ccacatggtg gctcacaacc atctgtcatg 10680
ggatctgact ccctctgaag acagctacag tgtacttaga tataataata aataaatctt 10740
agaaaacaag tagctgaggg aggagttttt tacttgtctc atccagggtg cctggaggat 10800
gacggcgagg cgccactttg cttacctcac caagtgagag ggacaaaaca tagttttgat 10860
ctgcagtagc ttcgcggtga gcaccacatc tccacctagt cctccgctat tgtcggctgc 10920
tatgaacaga ccctgctgtc acctggccat ttatctccat ggtcctgttt aagctctagc 10980
ctattgacta aggggatgca agttgaagtg gatgtcccca cgtttgaaca cagcactaca 11040
tgctggtatc tgaaatctga gtcacatcta ggtcagtcac attttctaga tttatgagtc 11100
tagattttat ttttccaggt gtcttgtttt tctgtctcta aatgatgaca tccacccccc 11160
tgccttcccc ccccccccca cacaccatat accctgggta tggttatttg tagcaaaatc 11220
aatactcttg tacttgaata atttttttct ttgcattttg aaccaaggtg tttattcaca 11280
aaaggaagaa ttgtccattt gtctgtctgc tcagtctttg gcttagcata gggcatgtgc 11340
agaggctcaa taaaaatctt ttgcctcaat cagtacatgg cacatgcatt acctcagggt 11400
catatttgta aataggtatg ggtgtttgcc tacaggtgtc tgtgcaccac ttgcatgcag 11460
gtgcctgagg aggccagtag agggcatcag atctctggga actggagtta cagatggctg 11520
tgagtcacca tatgggtatt gagtacaaga gagactctgg aagagcagac agtgctctta 11580
gccactgagt catcactgta gcccgcatgc catattatta aggaggctga acaccaagtg 11640
attcagcctc gctacagaca agtagaaacc tgtctctggc ctccttaacc acaaagttgg 11700
ggggcttccc tcgacacaga agccagagaa ccatttgaca ccgttcctct gtcacaggct 11760
gtatcattgg tccattttcc acatgacact gtgcattcaa gcattcatct ctgcagatcc 11820
ctgggcagta tggcagtgtg tgtgtgtgtg tgtgtttgtg tgtgtgtgtg tgcttgtgtg 11880
tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtttgtg tttgtgtgtg tgttctaatt 11940
ggaaaggaaa tcttcacttg cctttaaagt gcagtgctac tatatttctt tgcaaatata 12000
tatacgtata tgcatatgta tatgcagatg tatacacaca cacacacaca cacacacaca 12060
cacacacata tctcaaagtt cctttcaggc tgaagaatcc attattgtcg ggccagtgag 12120
atgacagagc agtttaaggt atctgctgcc aagtctgatg acctgagctc aatccctgaa 12180
atccacaccg tggaagggga aaactgtctc ccacgagttg ttttcttgac cgccacaggt 12240
gtatgcaaat atgcatgtgc acgtgcacac aagcactaaa taaacagaaa gtttaaaaaa 12300
ttaaggtata tattatttac tatgtaagag aacatcaaaa aagtcttgag aagtacacca 12360
tgggagaaaa cacacctagc ccttcaaata atttgccctt ctagaaaaat cctgaaatag 12420
ccctttcccc atacagtagt agaatgataa cattatctca gagatgagca ggcgtttaag 12480
gctcagcgga acgggaagag agttgggttt ttcttcctat ttgttttgaa tagctctgct 12540
cccgggtcct ctgcttgccc agatgatctg tgaaatgggt gagtgagcag cgcacctccc 12600
cagcgcgact gttactgacg tcagcaagcc tcattagctg ctgtttgtct aaccaaaggg 12660
aacagcgggt ggagagaatc ttaatgacct gacttcccac actgcaggtg ccacttgcct 12720
ggtgtgcacg ctgagattgc atcagctgac taggcaaaca aggaacagtg gaaatgggag 12780
gcagagaaaa agcccaagag agactgccca gtgagtggaa ctcgctgctc catcctggga 12840
gagtgtagca gagatgtttg tgcgtggtgg agtgaggtcg actcaggttc acagctgtgc 12900
gctgctacat agtagttgag ggtcgaatca cttaaaggct ttagtcccgt tttcaaaatt 12960
aaaataggga taatgataga accttaggga gaaggaggga cacgtgtgta aatcacagac 13020
ctcattgtac cactggataa ctggcaggag ccactgtttc tgactctaca gtggagagaa 13080
gggaagagca atgattggca ctgtggacgc aggtggcaga gaacagctaa agatgacttt 13140
atatcctaaa ggcaagtggg gtagctgtga gttttaaaga ccgaaccttg cttcacaaaa 13200
ttgctcttgc tttcctacct accaattctg cgttctttct ttttccctgg cagcatctcc 13260
ccggcggact cagccttggc tacagcggag actcctggga aggaaatgtc cttccccagc 13320
cctaggcaca gtggttattg tctgttctca catcctgtga gccctgtagg cagaggaatg 13380
ccccagaacc acagcaactg tgcaaacatt tgaattccca cgggtagttt cccatcctcg 13440
tacccatgag gcttctgctc tctgtagtca gaagaacgta cacagttctc aggagcagga 13500
agtagagggc taggaatcat gggtgaggag cctagcatgt gtgtgaatac atccgtggaa 13560
aacgtttttg agggagatag tacagaatcc tactccaggt gaaataatga gactcttgct 13620
aagaccacgt acggatgacc caatcaatac acaaggaggg agttgaaaag gagaaaaggg 13680
gttggccatt aatttagcca acgtataatt ccacgtatta gcaagtaact ttaattatcc 13740
tatgcgccct cggttttatt ctccacagct gtaaatggta ataatacccc ctttgaacat 13800
ttatcatgat taattaaggc agtgttgttg aaacatattg aaagttacct aggctaactt 13860
tgtccaattt gccagctgct ttggcaaatc ctctgcactg gggctggctc aggctagaac 13920
tatcttccat ctgggtaaat ctcttctcca ttccagagca gatatcatgg cgggtagctt 13980
gacctcacag tcatgagaca actcaaacca tggggattgg caaatgaagc aagtccttgt 14040
tattgaactc tccactcaga aaaaataaaa aataaaaaca tattaatact acggaggatt 14100
ccagtgacac tcccttctgg gaaagacact caagagattt ttatgagcag tcagggcaga 14160
tggaagtcac aaggcaaaca cctcaaagta aaaaaaaaaa aaaaaaagat caacatacca 14220
gagcactcaa caagctgaca gtctggctgc ccatgctaga tgcttagaat acatgaatga 14280
caaagtttgt atgcagtctc tgcctttagg gactttactg ctaatggggg attgtttatc 14340
aaacctaaat aatatccttg agggaatatt actatactgt gggtattagt gttcttaacc 14400
aatatgggtg ttgactttgt ctgtgtctct ctctgtgtgt gtacaacgtt tgggagtcaa 14460
ttctgtcttt ccaccacatg ggtcctggct atcaaactca gtctctcagc attactggaa 14520
gatgcctttg ccccatgagt catcttgaca gcaaaattgg gtattgagaa cttgaaagtt 14580
tgctgtgtga agaataagta aaacatgcta aaaaaaaaat aaagtagaca ggctgcacag 14640
atggctcagc agttaagagc actggctgtt cttccagagg acccaggttc atttcccagc 14700
acctacatgg cagctcacaa ctgtctgcaa cttctgttcc aggggatcca actccttcac 14760
acatgcaggc aaaaacacca atgtacatac aataaaaata aataagttat ataaaaatag 14820
gcaatctcat agttttacca tgttaattat atgttaaact agcaatgtgc atatattgca 14880
ttaaataaaa atgattcctt aactaaatta atttctttaa ttaaataaaa tgcaaaaaaa 14940
tgaatgaaat aaaatcactt tcacaaggtg gagaaacact ttgggaagac atccagatgt 15000
gaacctcagg cctccacata cacaaacatt aataagtatg ttaattaaaa ttaatttcac 15060
tttactttta aaaatagaac tactagattg tttaggatag aatatataac ttctgcccaa 15120
tatttgctca tattcttttg gaaaatatgt gttcaaatcc tttgcttatt cttaaattag 15180
attgcttgct tttattgttg tatttttttc tatcccaaat agccaaatag tatatttgtt 15240
tggaggtgta tgtggctgtt ttaagacagg atttcttttt ctttttcttt tttttttttt 15300
tagctctggt tatcctggaa ctcactctat agggcagatt ggcctcaaat tcacagagat 15360
ctgcttgctt ctgcctcctg catgctaggg ttaaaggatt gcactggtgc tgggcatgac 15420
aacccccccc cccctttttt tttaaccttc actggtatag tacaaatatg gcacacagac 15480
cattcaccca tacacataag agaaggacta aacaaatatg tttaaacatt aaaaaaaaaa 15540
aaactattgg aaacggaatc gtcaaactgg aatggtggag atttcatcag aactggcttt 15600
gttcattttc ctgtctccgt caaactgtct gctctgtcac agtctggttc tccaccacgt 15660
ggctgctgct tctgttggtt cagatccctg ctccgcagtc tgagccaatg aaatcccggc 15720
tcttcacaaa ggcggtttta gtggcaagtc tttggggctt cttctgttct cttggaagaa 15780
tggccccagc agcttcttcc atagcgcttc tggtgaacca gatggcatct tgttcaacct 15840
cttactgcac tgagcacgca gcctcccctt acaagattca taccaatgtc tcattgtttt 15900
ccaaagtaac ttgagacttg aactttccca gactctcaaa taaaaccatt ccttgtggaa 15960
gagtgcggtg gtctccagtc tttagagact gcctgcctac ctaagcttta ggggacagag 16020
tgggacaaca ctaacaaggt gtgtgggcat gacaacctct aatcttctca gctagcttca 16080
cctggaatct cagtcttatg agtaatctgg actaacagta agggactcat tatttgatgc 16140
ttgccacatc tggggtcaaa tcttggcccc tagaaatggg agatggatgg acaaagatgt 16200
cctatacctt tagctatacc ttctaagaat tcagcctcaa cagcttggag acagacggga 16260
ggacaaacag ggtgggcttc cctggttgct gggcccgctt agggcttggc tgtaggctga 16320
aagggaaggg agcttgctct ctcggccaca cactgtactt gcatctccat cgctgggatg 16380
cagacagtga agagaacaga ccgtagctct gcttgttctg agacatagga aagcgctcca 16440
acaaatgttt cttcacctat cgtatgctct gaggacaatt tccacagact ctagatgatc 16500
atcgttgcac aatttttagg aatcttcgca gtttccttga agtgtgtcct caagagttcc 16560
tgatgctgcc gttatagaag tgggagtagt tgggggtttt atagacaaac tctaaaacta 16620
aaagaaggag atatacacag ttacagaagt gtttggtcag caaggagtca aaaaattagc 16680
cagtgcacac taggcagcat attaaagtat ataatatagt atatattata tactatatat 16740
attataaagt aatgtattac aaagtaatat attactatat attataaagt aatatactat 16800
aattaatata taagtaatat actataacac atataatata taacaaatat aacatataac 16860
atgatatatt atattatatt atagtatagt atagtatagt atatataata agatactact 16920
ggctactaat ccatccaaat ctagaatgaa ccctgtgtaa acacacagga aaacagtggg 16980
aaatctagta gaaaactgga caataggtat taataggaaa ttcacagaag gcaaaacttt 17040
tcaaaatgac aagttcatga atggggcttt atcactatta aatcctttaa aatgcattta 17100
aatgccaagg cgatggctca gctgttaaag agcttgtggg gggatcagga ggaccagaga 17160
ttggatccta gtatctgggc caatgtcaga aggatgtggc agcctgccta taatgctagc 17220
tttggaaggt ggagtcaggg tatccccaga acaagctggc tcgtgggatt agccacattg 17280
gtaagctctg ggtttaattg atagagcctg aatcaatgaa gggaggagag agtgacacaa 17340
agagactcct gatgtcaacc tcaggactct cttcatgtat gtggacacat gtgcatgcac 17400
ccacacacac gtgtgtccac atatttgaaa acagatattt acatacaata cacacacaca 17460
cacacacaca cacacacaca cacacacatt caaagtaagt aagtgcataa aaatggttac 17520
attgtagcag tttgtatatg cttggcccaa gggaagtggc actattagga ggtgtggcct 17580
tgttggagga agtgcatcac tgtgggggtg ggctttgagg ttcttttttc cattttctct 17640
atttgatttg attactacag ccatgaaatt atgatgatct acatatacag attttatgac 17700
aagaaaagaa aaattcataa aaattttgaa gctggagcag tgattctgtt ggtaagatgc 17760
ttgtaagctc tgggctcata tccacttatc agtgagtgca tatcatgtgt gtccttttgt 17820
gattgggtta cctcactcag gatgatgcct tccaggtcca tccatttgcc taagaaattt 17880
cataaattca ttatttttaa tggctgagta gtactccatt gtgtaaatgt accatatttt 17940
ctgtatccat tcctctgttg aaggctttga ggttctatgt ttaagctcta ctaagtgcag 18000
aagaaagctc tcctggttac ctttggatca aaatgtagac ctctcagctc cttctctagt 18060
accatgtctg cctgcatgcc gccatgcttc ctgccatgat gataatggac tgaacctctg 18120
aacctgtaag ccagtctcaa tgaaatgttg tccttcataa gagttgcctt ggtcatggag 18180
tctcttcaca gcagtaaaac ccaacaaata tcactaagca atttttaaaa ataaagctaa 18240
gggctagtga gacggcttgg cggttaggaa tgcccgctgc caagcctgaa gacttgatga 18300
gtttagtttc cagaatttat atggtggaag gagagaacaa actcttagaa ctgtcttctg 18360
accttaacac acactgtgtg ctacactcac gcctacacaa atgcatgccc acgtaaacaa 18420
atagatgcga aagtcaatgt aaatacaatt ttttaaaaaa aaatgaataa catgcagtta 18480
agatgaggtc atattatact ctcaccattg gacaaaactt atatgttatt gtcctcattt 18540
ggttctgttg ctgggataaa atgcagacca gaactaacct gtggatgaag gggttcattc 18600
tgtttatagt ttatcctcct tcactgaggg aaggaaaggt ctacatcacc cagaggaaga 18660
actgaatgaa gcaaagacca tggaggaatg atgcttactg gcttgccccc aggctcaggg 18720
tcaacgacct ttctcatgcc tcccatagcc acctgcccag ggatggccca gctcacaatg 18780
gcctgggtcc tgtcacatca atcaacaatc aagaaccttg cctcacagac atgcccacag 18840
gccatccctc aaccaagatc tctccctccc acatgactac agtttgtgtg aagttggtga 18900
aaaccagcta gcagtttatc aaatcttggt gggaaaaaga tagagagaca gaactacgct 18960
ttgaggagca acttggtggt actaagtgaa attaagtata tataattatg gctaaggaaa 19020
taacattctt gggttaatac cttagaacat cttccataaa caaactagag gaaggtaatt 19080
taaagcacaa ataggcaact aataccatct taaactaacc tacacaccta cgggttatga 19140
atggtgacca caggctctgt atgtctacta agaaataact atgtgagtca aaatgaaaga 19200
accaatcgat ctacatacgc cagcaaggac ggtttctaac tgtgcttcgg atcgtaaaga 19260
taacaaagca aaattagatg atagcatatt aaaggttatg taacatgtga atataatggt 19320
ttctgtggtt cattgttaca tccgtttatg aatgaagctg tggttggtga atggtatgca 19380
ttaggataat aagcgtgggt acctggtaag agaagagatg aaaatggctg gaggaggcag 19440
tgattacagt tccattcaga agggaatcta gagcctggga gatggcttgg taaagggctt 19500
gccaagcaag catgaggatc gaagttcaaa tccccagtcc ccgtgtaaaa agctaggcag 19560
agcaacacat gctcagagcc gaggagtcag agacaggcag atctctggag tgcactagtc 19620
agctgactca gctgagtccc tgcactccag gtttagggag acactgtctc aaacaaacaa 19680
acaaacaaac aaacaaaaca gctggaatgt atgctgactt agttttactt gacatagcta 19740
gagtcacggg agaagaggaa acccccaatt gtgaaaatgc ccccactaga ctgacccatg 19800
ggaaagcctg tagtgaattt tcttagtgac tgctgtgaga aggcccagcc cagcatgctg 19860
tgagtgggtt gtcctgggtg ctgtaagaaa gcagactgaa caagcatcgg gaggcaaaag 19920
ctgataagtt gtcccttcct gtctccaggt tccttccctg atgtccttca ctgatggagt 19980
gtatctgaga gttgtaggct gaagtcaacc ctttcctccc caagtagaca ggaggttaga 20040
aagatagccc tgtgggtcag agtgggtgcg gtacaaatag gaggatgcac cttcatatct 20100
caacctttgc atgagcatct gggtgtagac acacttatgc ctgtgacacc tccttggagg 20160
tggtgatcgt gggactgact ggccaccagc ttagtttcag gttcaataag ctaacctgtc 20220
tcagggaagt aagatgagga gtgagagagt ctggaacacc ttctctggca tttgcacgca 20280
catatggata cctctccaca tgcttataca gtacatacat acactccact ggcatgcaca 20340
cgtacacatg cacaccaaca acaaaaaagt aagttgaaaa aaattaaaga aacactccat 20400
gttaacttat ggcctttaca tgcatacata tatatgtgca cacgcacctg catacactta 20460
cacagaggga gagattacat aggcgttgtc agcagtgtgc tgcagacaaa gaggtatgat 20520
cagtctttct gagatgaatc ttagtgatga ggattccatg atgtatgagc aacagggctg 20580
ggcagtgcag ccagctggtg ctgcatctcc tttcagtttg gattatctta ttgggtcaca 20640
ccagaaccag ggagataaat agtcaagaca gactttgaaa attcatacac cacacacaca 20700
cacacacaca cacacacaca cacacacaca cacacaccaa taaagctagg tttgaatgaa 20760
ttacttttgt aaaatccagg tctgagttgt attctgaaag ctttacttgt ttggactggc 20820
cagtagctca gtcaggcaaa aagacaccac acgggagggc agactttaaa gaagaacgtt 20880
tcaatgaggc aagctgtcac ggcttgtgtg aattacacaa tgaaagggaa aataaaataa 20940
aactatggcg ggctaaaatc tgtaagttct gacatgtggt cctcgtggca ccatctgctc 21000
atgaaagcat gaagaggctt ctggaacttt ccaggactgg gttgatttgt ctccacaaag 21060
ctgcctgggt aagaccctgt ggcactgggt catcaagaag gtactagcag acttcctttt 21120
tatctcagta tttttctacg tcagtcccca aaccatgaaa caacagggct taccctgcca 21180
caccaaaggt caaactatgt tttctcttac ccaactattg cctgggatgg ctccaacttt 21240
attactaccc cacctccaac ccgtaataac tctccagctc tcacttcaaa tccaagagag 21300
tgtggactga gtgaggggac cagagacagg tgcatctggt agaaagttat actcaattaa 21360
ctaactgaat gcatttgcat gtggttttaa ttccactgtg cagcaatttc ctgagtaaaa 21420
atggagagat tatatctagt ttttgagtca ctgtaagaat taagtaaacg tagctctcaa 21480
tctatatctg cacattattt ttcctcgtgg tcctagattt ctcttgttcc tgaccatttg 21540
tcccgtcttg gaatttcccc agccttcaga ggtgtagccc tataatttac cgtccagatt 21600
gcaatccctc ttcatggcat gaattaagtc ttatctcacc aggaagtgct ctttcctttc 21660
ttctgactcc tctccctctg gctttcctct tcatttcttc tctacactgt ttagggaaag 21720
aggtttctta gcaaatcctc agacacccca actagtgggc ttcccggaaa gtctcagccg 21780
tgtgtgggag gtctgccctg aagaagttct ttgccagaaa atgaagcaag gtgttctggc 21840
tggacagtga gggtggtaga ctgtaataag tatgtctggc tttaactctt ctatattcat 21900
ctgaggggag catctgagcc caacacaaca tctccatcgt caatggagaa tcctactcag 21960
ctgacaaggc ccttgcttct gtgttgaagg attacagcaa tggcctcctg tttattgacc 22020
tcatacttag acccatgagg catgcatatc atagtttatt tctcctactt agcaactgaa 22080
aatactaaag ggagtcacag agtctgactg ctctcacggt ctgtatctat tgcttaatcg 22140
aaagcttccc tgttaccctc ccatagcaaa taagggtcca tcccacaaga cactgtggaa 22200
acgcctcctc tcaagctcct ccagacctcg cagtgagtca atagagagca gaggggtctt 22260
acgtctctgg tgcctaaaga ggatggggtg ggcgttaggt ctcagcaaga acatctcttc 22320
ttatgtggcc agcggagagc ccagaaatct taagcttttt cataagggtt tctttgagac 22380
gcttcctaac ctagtgatcc ggttatcacc aagctaaggg aaaacgatca cgtgacacga 22440
aggatgaagg aaaaccctca gattcctcct cctctgaatc tgggagtgga aaactgagga 22500
gctgagctca gagttccaga gccacgcgaa gctgggctca gcagtgtttg cagctgcagg 22560
tctggtgagc ctgtggaaag agagaagggt gagagaagag agtctccaaa aagctgcccg 22620
aattagagaa acaagagacc ctgcctcaaa aaggcagaca cctcaagtgg tcctctgact 22680
tctgttcatg tgtcatgaca cgagcatccc tgaatccaca tacacagctg agaagcgtgt 22740
acacacacac acacacacac acacacacac acacacacag agagagagag agagagagag 22800
agagagacag agacagagac agagagacag agagacagac aaagagacaa agagacaaag 22860
agagagaaac agagagtggc tgaagggagg gggcagggga aggagggagg gggaggggga 22920
gagacaaata atttataaaa ggaaaatcat ttaaaacatt tcagggctgc cgagatgacg 22980
cagttgcaag caggaagccc tgagtttgga gccccagaac gcatccaaaa gccaggtgtg 23040
gagcgtgtgt gttctgtatc tcagctctgg aaacaagggc ctcgccatct attgccaatg 23100
ggctgccaaa ccaacaagga gcgagcaagc cccacttttc acgtaaaata cctcaaagag 23160
aaaagcaaca gatgcaaagg ggagagaatc tcgcttttgc ccagatcatg tagcagcccc 23220
gctcttagag gacgtactcc atgtctatgt gacttcaact ttcaattcta caaaaagggt 23280
tggtttcatc cctctcttct caatctggaa acagttcgtt ttaacgacag atgggtgata 23340
ttacacttag aatcaaactg ttaagccatg tgaatgaatt tatggtcacg tcatttcgaa 23400
gcgtcccctc tacaaccccc ctccccccgc tgggaaaaga ggggcttccc gctttcccag 23460
gaagggaagc tgtgggctct gctgggggac acacactgag ggactttcat cagcatccct 23520
cccaagaggg aagggacatg tctgtgggcc ttatggtctt caaagggacg taaagccgtt 23580
gcattctgat tagtttgtgg agggtacttg tttcaatcca gctacagttt ggtttgtgca 23640
gctggtatct gctgagcagc tgccgggacc tgtgtactct cgaaatcggt gaggctaacc 23700
cctgagaagc agagggtcgg gtgtcacgag agacttttct ttcccttttt ggcagccata 23760
ttgaaagatt cacagacacg ctcttaactt atccatgcaa agtgagactc tgctcacatt 23820
ccctgatact ttccttcaaa atgcaccagg aaatgtcagg aaataattca attagtctca 23880
ggaaatttac aaactgtgca aaacgttttg aatccacttt tagaacactt tcaatgacca 23940
caaaagctga agaaagggca gaaagaggca agggaaagag gaaaggaaga aaggaaacaa 24000
acaagcaaac aaatccagtt tgtcttcaga aggattatgt tggaggttcg ttttgcttgt 24060
agagactagt tcatctattc caggcttgct ttgaattccc tgtataatgg agacaggccc 24120
tcaacttctg gtccttcggc ttctgtgtgg cattacagtt gagtgctatc acacttaatt 24180
atgtcagagg cgtttttgtt tgtttgtttg tgtttatgtt ttactttagc agtggctgga 24240
gttggggtgg ggttgggtta ctccagcagc tcccaagagg atcagccttt caggctgtcg 24300
ctggaagggc agctatatag atgctgcaag aaaagcaact agctcctgct cttagagaac 24360
ttttgtttat tattattatt aatttacttt atttacattt aaaatgttag cccctttcct 24420
ggtttcccct tcgaagaccc cctatgccct ctcccctccc cctgatcacc aacccaccca 24480
cacctgcttc ctggccctgg cattccccta cactggggcg ctgagccttc actggaacaa 24540
gggcctctcc tcccattgat gactgactag accatcctct gctacatatg cagctggagc 24600
catgagtccc accatgtgta ctctttggtt ggtgatttag tccctgtctg ggggtactgg 24660
ttagctcata ttgtttttcc tcctatgggg ctgcaaatct cttcagctcc ttgggtactt 24720
tctctagctg cttcattggg gaccctgtgc tcagcccaat ggtaggcttc gaggaaccac 24780
ctctgtattt gtcaggcact ggtggagcat ctcaggagac agctatataa ggctcctgtc 24840
agtaaggtct tgtactcagc tattaaaaag aatacattta tgaaattctt aagcaaatgg 24900
atgaaactag aaaatattat cttgagtgag gtaacccaac cacaaaagaa cacacaaata 24960
cgtggtatgc actcactgat aagtggatat taggccagaa gcttggaata cccaagatac 25020
cattcacaaa ccacatgaaa ctcaagaaga aggaagacca aagtgtggat tctttgatcc 25080
ttagaagggg gaacaaaata cccatgaaag gagttacaga gacaacgtgt ggaacagata 25140
ctgaaggaat gaccatccag agactgcccc acctggggat ccatcccata tacagtcacc 25200
aaacccagac acttttgtgg atgccaacaa gtgcttatgg aaccttttat ctatagagaa 25260
ggtttctcag ctttggtagc attaattaat tcgttgtcat ggaaaggtgc cgtttacagg 25320
catcccttcg cctctccctg tagttgccag aaacatctta gatatggatc aatatcttct 25380
ggggccagga gatattccca aattgagaac cattggtcag cactctgtct atcatgactg 25440
caaacaaatt gaaaacttga caaacattaa tgaaaacttg ataaacatta atgaaaagaa 25500
actcagaaaa cactttgata gtattttctt taagacatgc catgcgtggt ggcgcatgcc 25560
tttaatccca gcactcggga ggcagaggca ggcggatttc tgagtttgag gccagcctgg 25620
tctacagagt gagttccagg acagccagag ctacacagag aaaccctgtc tcaaaaaaaa 25680
aaaaaaaaaa agacagggtc tcatgaaacc cagactggcc ttgaactcac tatgtagctg 25740
tactgcctgg gtttgtgtgt caacttgaca caagctggag ttatcacaga gaaaggtgcc 25800
ttccttgagg aaatgcctcc atgagatcta gctgtaaggc atttttttca attagtgatc 25860
aagggtggga gggcccattg tgggtggtgc tggactaacc tgggctggta gtcctggatt 25920
ctgtaagaaa gcaagttgag caagccaggg gaagcaagcc agtaagtaac acccctccat 25980
ggcctctgca tcagctcctg cttcctgacc tgcttgagtt ccagtcctga cttcctttgg 26040
tgatcaacag cagtatggaa gtgtaagctg aataaacccc ttcctcccca atttgcttct 26100
tggttatgat gtttgtgcag gaatagataa cctgactaag acagtagcca acgatgatgc 26160
tgagcctctg attctcctgc ctctaccttc tgagtactgg atttacataa gtgagctgtc 26220
acaccagttt atatggtgct ggaatcaaac cacaaaggct cccagcatgc aaggcaagca 26280
ttctctcaac tgagctacag cctcagtttt agcaatgcaa agaagaggaa aaggagggag 26340
aagatatata tatttttcat tacatatatc tcacatatat tttacattac aaatatctca 26400
catatatttt aaagcgctgt agtggtgaga tattgggctt tgtagacacc aggcattctg 26460
ctgtcctggt tcttcaggct ttatgatctt gaacaccata gttctatttg gtgagtctgt 26520
tttctcagga gttgttgact atgcctttag tccagtgcta tctgaagaat gaagatagta 26580
tctctctcag tacacctttg gcaagggaag ataccatctg cccagtatca tcatgtacat 26640
tggttgagag ttaactctgt gctaagtgtt gtggtaaatg cattatttct tattccatcc 26700
tcatggcaat cctaccaaat gtcaaaaatt attatccaca atttgtagat aagaaaacca 26760
aaactttgac acattaaatg actgtcttag gattttgttg ctgggaagag acaccatgac 26820
caaccaaggc aactgttaca aagggtaaac atttaattgt ttctctgagc acttctgtct 26880
tccaggattc taccacaatg gcctttctgc tctatttaca gtattcaact gtttttttag 26940
tacaaagttc caaggtcgtc cacagtcctg caaaaagcaa cacaatcagg tacttcccag 27000
caacggcgat tcttgagtat cgatttctgt attatttaat cttctgttgc tgtgataaaa 27060
tgccacgact aaggcaattt acagcagtaa gagtttattt gggcttacat ttgcagaggg 27120
ataagcgtct ctcatggtag ggagattgga aggcagtgag tggggcctga cagctggaat 27180
aggaagcaga gtgatcacat cctttactgt gaacaggaag cagagacagc aaacagaaaa 27240
tgggctcaag ctaagaaaag aactctcaag tccagccgcc agggatgcgc ttccttcagc 27300
aaagatgcta gctctccaac agcatccacc atctggggaa ccaagtgttc aaacacacgg 27360
gtctgtgagg aatatgcttg accttaacaa agctagggaa atgtgtagac tcctctacac 27420
agctggaaga tgttcactct ctcttctttc ctttaaacag tttcttaaaa attatataac 27480
ccactcatat tttcctaggt gttacaatca taccttacct ttaatcacat tttcatttat 27540
ttgtttgttt gagattttat gtttaattat gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 27600
gtgtgtctgt gactttgtgc acatgaatgt ggtgcccatg ggagccacaa gaaggcatca 27660
gatcatttgg agctgggaaa gcagagccgg aggcagggac atctggcaga gttcagagtg 27720
gacatgacta gactgagctg ggtcatgtgg ggagatgtgc agaggaaggg aaaggggaga 27780
gatgggaaca aggtgcggca ggcaagagag caaagataca cacacacaca cacacacaca 27840
cacacacaca cacaccacat atgtacatat acacatacac acatgcacgc acgcacacac 27900
acacatattt agatgcattg aaatcatttg atatacaaat agaccatgca aagatcaagt 27960
cagtgtgatg gacatttcca gctgtttaaa ctttttaata cttgttagta ttgagagtcc 28020
cacccccacc ccatttcact gctttacaaa gatacaaaac attgttctgg gcatgttggg 28080
tgcattcctt aatcctagtg atgcagaggc aggcagatct cggtaagttg aaggctatcc 28140
tggtctatac agtgcattcc acgctagcta gggctaccag tgagattgtt tcaaaaaaca 28200
aaagtctgta gttatcttcc tatattgttt attcttctct gccttcctct ttttctgcac 28260
acctgtcttc tctgacactg gtcagcatgt gtgagtgctt gggcccgtta atttgtgtga 28320
gcagacatgt gtcaacatca cttagaggaa aggtggcaga ctcattaaca cacacgatta 28380
acatgattag gaccagtttg aaagcagcag ttctccatct tcctaattca ggcctgactg 28440
tgtcaggact ctacactctc tacactgttt tctcagctaa cttgtccttc ctgtctctca 28500
cctcttcccc acactgacac acatgtatac acagcccccc caccacatac ctaccccccc 28560
cctacaccac agacttccag agagagggag gtggtgacta cgctgtatgt gtttaactgt 28620
tacctgtctc tccttagttc tgaatgaaat ggaatctaat cttaatcctt tcctgtcatt 28680
attagattca tggagtccta acggccagag tctctagatc ctgtcttatg aaattcaact 28740
ctcatacaaa attcaaagta tcagtttcag agaaagttat ttgaaaaaaa aaactgtgga 28800
gttgaaagca attgaggctt attctggtcc tcttactcag tgtgtgtgtg tgtgtgtttc 28860
tgtgtatgaa tgcatgtatg catggggtat acatgcatgt atgcatgtgt gttcatgttt 28920
ggtgtatgca tgtgtgtatg tgtgaggtat gtgtatgttt gtgaggtgtg tgtattgtgt 28980
gcatatgtga gcacatgtgt gtgtgtgtgt gtgtgtgtgt gtgtatgcat tcagagacag 29040
agtgtgctca gcttccagta gatcctcagc taggaggtgg tatcttgtga gactcttccc 29100
tctgcatgct gaactgttga ccggcttgac ctgtgaaggt cttgtgcagg caaccacagc 29160
tgctgagagt tcatgcatgc aatagtcttc atgtttattg tagttctccc taactctggt 29220
tcttaccatt tttctttcta gtctgtgatg ttctctggat cttgcaggac aggccataat 29280
gcagataccg agttttattg atgtcaatgg tccactgggc tagcagcctt actgactctg 29340
ggatagatgc tgttaaatca atgacagtgg ctttttaagt tacatccaga cgttaggcag 29400
gaatagataa ctcagatata acacgaaggc ttacccctgt gtttttgatt ttaaaaaatt 29460
gtgagtgtgt tatacgcagg catggttatg cacattgatt tgtgtggttg tgggatctta 29520
tgtcagaggg acttagatgt cttcctttat tactaccgat gttattcttt tgggacagga 29580
acctggactt catttctttt tgccaggaag tcagaaagcc ccagggatcc tcccatctct 29640
tccttcttaa tttctgggct tctgtaggca tgagcaaaac tatgcctggc ttgttaggtc 29700
ggcactggta tctgaacctt tgcttccatg gttgtacagc aagtgttctt aactcatgag 29760
gtcccgattt ttttgtttta cttaatgcta tgttgtactg tattatatta tgttttgctc 29820
tctctctctc tctctctctc tctctctctc tctctatata tatatatata tatatatata 29880
gactggcttg caccatggag tatgtgtcag tcaggagata ccttttggaa gacagtgcct 29940
ttaaaccatt gaaccatttt tctgcccatc acaaattctt tggactaaaa aataagagtt 30000
tctttttcct taacaggaca aaactttatt ctctgatatt taaaatataa gagaatattt 30060
caaaatttca aaaaccagtc ccttaagtta aatcaagtgc ctgctccttc acatctctct 30120
tctcttttga tgtaagcact tattgatcta aactcacttc ttgaaaactc ggagcatctc 30180
acaggcttcg ctatgttgcc tctctacttc catttgcctc aagataattt ttaatttctc 30240
ttttaactat ttcattagcc tattgattat tgaggaccat gtcaaatttc ctaggttttg 30300
tgcccccctc ctcaccggag actttgaaag aatgtatgtg ctgcaaatga caacttagtt 30360
tcttgaagtt tattaatttc tttatgcata tgtatatttt gcatttattt tcactgtttt 30420
gctcaatgtt tgtcattgtt ctagtttcct ttctgttgat aaaacactct gaaaagcaac 30480
tttgaagaga aaaggacttg tttagtttgc tcttccaggt cacagtccat tactgagaga 30540
agtcaaggta agaactctag gcaggatgcg ggagccgtga gggagtgttg tttgctggct 30600
gactctctgg aatgttcaaa ctagttttat tatatagttt gagcctgcta gtctagggat 30660
ggtgctgccc acagtgggct gggtcctccc acatcaatca atcatgacat tttctatgag 30720
acacggccac aggacaatat gatcaaagag atctctcaat tgaaaactga aaaaacttcc 30780
tcttcaggtg aatctacgtt gtgtcaaggt gacaacttgt ccagtagtac taagcagggc 30840
agtcatcttt aatcagagag atgacagtat atattccctt actgtatggg tttgtgttga 30900
gacacctata atggcagaca gattaagtct tcctgcatct gctcagagcc cctgtccaaa 30960
cagttccttc ttccctcttg tctctccttc ttcagacagc ctacacaatt cataagcagg 31020
agaaaacatc cataggatgt tttccagtta gtgttctaga atttcagtag tagaaaggat 31080
ataaaaatta cttagaaaca gggagtactc aatggcaaag tgcttgcctg gcatgcatga 31140
agccttgggt ttatcacccc cccccccact cttagtccat atttatcatc tttcatttaa 31200
ggaagcttaa aataccagag gactagagag atggcttatt ggtaaagagc acttgttgct 31260
cctgcagagg accagggttt ggtttccagc acccacaagg tggctcacaa ccatcagtaa 31320
ctctagtcca ggatgtttga catctttttc tggcctctgt gggtactagg cgcacacata 31380
gggcatatac atacatgcag gccaaacaca aaagtaaaaa taaaaaatat tgtctaaaag 31440
ctatctcaga cacagggaag tgcagagatt tatcctaaac cacactgttg gttaatgtga 31500
aagtcaagct aagataaata aataaataag taaattaatt aattaattaa taagtaatag 31560
agggttggag agatggctca gctatttagg gtgcctgcag ctaggatgca tgttttgttt 31620
ccaggggatt gggggcatga gagaaacctt acaacctgct acagggaatt ggacatgctc 31680
tcatggcctg tgaggatact tatacacaga agacattctc tctctctctc tctctctctc 31740
tctcactctc tctctctttc tctttctctt tctctttctc tttctctttc tctttctctt 31800
tctctttctc tttctctttc tctgagacaa acacacacac acacacacac acacacacac 31860
acacacaaat aaaaacaaat cttggcttat ctgtgcatcc tttaatttca tcactaggaa 31920
ggaagacaga tctttacaag ttcagggtca gcctgatcta caaatcatgt tttagatcaa 31980
caaaggttat gttatgagac cctatcctgt ctcagagaaa caaaacaaac aataacaacc 32040
gctcccccac tcttatggta aaatgaaaag ttactaaagg taggacaccc aagagcacac 32100
gggacgagga tttctaggca agcatctttg tgcagtgttg cacctattat tgaccagcat 32160
tgtttcagga aatgttaggc agaatcaccc cgctgttctc ggaagcaaaa cagaggtgtc 32220
acaccttctg attagactgg ccagcttgct tttcaaatca tctcttcttt atcatcaaag 32280
agagaaggaa acctcggaac aatgctgtct ctgcaatgct atccccactc gatcttatcc 32340
aaggctgccg tctttgttgc catagccacg gagacctgat gcgcaggtat ttgatcttgc 32400
tatgtgccac tgaagggtgg atattccatc ggagaccaaa gaacaggagg ttgttaagtg 32460
tgttgtaggg aatcagagcc atggagaagt tgtttgatct gagtccaggg ctgagcagga 32520
cattggtaca tcctggatga aagctttacg gtttgtacac agcttggaga agtttaagtc 32580
ttggaaaagc cgggcagatc ccatgtgtta actcctccat tgctgccagc ctttccaagc 32640
ctgtttcact taacaaatat ttattgagcg aggtcattac ctccaatttt cactacggag 32700
acttgaaaat taagacacgt actctgcctt tgaggacctt tgaggcacac agatgtaaac 32760
tggccattgg ataatatcat acatgacacg tctgagacac gtgaggggaa agtagaaaag 32820
ggtctatgtc tcatacagca aatgtataaa gttctgtagg taaagtgcca tttgacatgg 32880
ctcctaaaag tccccaaaga tagatttatt tatttattta tttatttatt tgcacatgaa 32940
taatcaactt gttgaaggac tgagagacca cagaaaaaca agcaggagga atagcgacca 33000
tccaggaaag aggcttgact gggcagaagg gtcaaactcc aggagacaga agacaatttg 33060
aattaagatt agccaatctc agagattcct tatgaatggc ttgatgataa ctcctcagtc 33120
ttagccagtg ggaagttttc taggaggaat tctgattggg cagatcttta gccacatgca 33180
atgcccgagg gtagaagatg tgtcttctta ttctgggcag ccacactgtc agctgaaaat 33240
agggtgtgtg ggttgtcatg tggacagtgg cagttcctat aatccatgcc tacctgtgct 33300
gtagctgcac tccttgactt acacacacac actctctctc tgtttctccc ttcctccccc 33360
ctctctccct cccttccctc tctccttttg cagaggtggg tattgaaccc ccgacctcgc 33420
acgttatgat agacaggcac gtatccctgg gcgctatgct gtactattaa cgatttgtat 33480
ccctttcctc tggagaggag atggcgggct tttcaaaaga aagaaagaaa tattcttact 33540
ctatctatag tacccaacag tgtctggtac acctacatac acagatatgc agggcccgtg 33600
gaaacacaac aattccactc ctgtttaggc aacttttcat gctctttttt tccctctgaa 33660
cttggcttca tacagttttt agtgttcaac cttagtcttg ttaaatccac tccaccatag 33720
ctcagcctaa tcatcggctt ttgaatggat ttacagaact agacacacat ttcctcctac 33780
agagcagacc ttacgtccca tcagaaagca gttggttaca cccaaatgtt gtatggccct 33840
ccattaaaaa agatgagctt atttgtttta tgtgtgtgag tgttttgctt gtatgtatac 33900
atgtataact tgtgcatgcc tgatgtctgt tcaggtcagg agcaggtgtt tgctggatct 33960
cctggaactg gagatataga tactatgacc tgctatgtgg gtgctgggaa tcaaatccaa 34020
gttctctgca agagcagcag gtgttctttt tttaagttaa tattttagag aatttcatac 34080
acaaatactg ttatttacct cattaccacc ccactcaacc tggatcctac ccccaaccac 34140
tcccttctaa aatttatgac ttcttcattt cttttttgag atttatttat ttattttata 34200
tgcctaggtg cttctatcta tgcacccctt acacggctga tgctcaaaga ggccagcaga 34260
gggcgccagg tcccctggaa ctggagttag agatgacggt ggcttttcct ccctttttac 34320
caggagacct agtcctcaca gaggttttca ggtcagttcc agtttgattc cttcaagtcc 34380
tgtgtccaaa gtgtgtgttg tctttagcca tacgcgttta atgtcaagtt ctgggaggca 34440
ccaaagagaa cagcagaagc cgctgggact tctctgacca acagcacgga ggtttttcat 34500
acacggtact agatagtttt tggctcttgc agggagcatt atagcccaag ctggtgtaac 34560
accatttaaa gcacacgtaa gcagtatatg catatactta cacttgtatt catttatgta 34620
ttatgcatgt gttcttttta gagatctatt ataggtgtat gaatgttttg cccacatccg 34680
tgtacatgca ggacatgtgt atctgatgcc tgagagagtt agaggagagg gcatcaggtc 34740
ccctggaact ggatttacag acagttgtga gcagccacga gagtgatgga gactgagcct 34800
gtgtcctcta caagagcagt tactgctttt aaccactcag cctcgccccg ctacgcgtgg 34860
atttttaagt aaacacgaaa taaacttttc ctttcgcctt ttcaaactca ctttgtctta 34920
tttatgcctc ttccctcttt tccctctatt ttattcttcc ccctcccatt aaagccccac 34980
ccccttttct attcccccct ccctttttgc taggacacag caagtgctct taactgagga 35040
gcagtctctc tagaaccccc gcccacgcca cacatctttt agagctgaaa atttcctaca 35100
gcttccgaaa ggaagaatca ggatagagtt tagaaatata accaacagag gagaagatgg 35160
caaaactact gctgccttca gcacagagag gctttaccta gaaaatgggg ggggaaatgg 35220
aaacatggaa aaatgcattg attggaaata taccgaggac atgggaagtt ttaagggtga 35280
tgagcttgag gcgaggaaac cagatttgta cagttttgga agaaacatgc aaagtttaaa 35340
ttcggctggg gatcagaggc agttatttta tggcaaagat gagattggtt ttgtccagct 35400
tggcctcatt tgtacctctc cattttagct atagtcacat cttattaata cttacctcac 35460
tctttggagc ttaggcagaa aatccattat ttatggttga gtattcacca tttatgtgta 35520
agtaaggaca tctgtatgcc attgaatatg tggttgtgaa gtaattaaaa cagtttacag 35580
tgtaaaatga aagacatttc tctattttaa acatgcaata gagaaatggc attttatata 35640
ttgtttagaa agatttattt atttatttaa tgtatgtggg tacacactgt agctgtacag 35700
atggttgtga gccttcatct ggttgttggg aattgaattt aggacctctg ctcgctccag 35760
ccaaccccat ttgctctggt tggccccact tgctccatcc caaagattta tctattatta 35820
taaataagta cactgtagct gtcttcagac acaccagaag agggcgtcag atctcattat 35880
ggatggttgt gagccaccat gtggttgctg ggatttgaac ttaggacctt cggatgagca 35940
gtcagtgctc ttacctgctg agtgctgagt catctcacca gcattttata ttctaactag 36000
attcaataga cacttttgtt ttgttttgtt ttgtttgttt tttgtttgtg atgaagaata 36060
ctaaggggtt tttacttagt tagcagtaag caagatgaac tgaatatatt gtatcaagag 36120
gcatcgagat tgcatggctg taactcaggt ggtgatgaag gaggataacc atcccctgga 36180
ggctaacctg agctacacag caagacccaa cccaaaagca gccagccaac caaaccaaac 36240
tcaaacccaa aggcccgtga aaaattgaat tctgatgatt agtgccccat aaggacctta 36300
tggaacatga aaacaatagg aagaacaaag agaacgagca ggtcagaacc acacttaccc 36360
aaattaaagt ctcccagctt ggaagatcaa atcatacatt acctcaagta actcatattt 36420
gtctgcaagg tgtcagctga ccccttttct ttaatatctc acttcccacc cccaccccct 36480
tttaaacaga aagacctttg attgtggtgg ccaataattt gaagttttga agaattaatt 36540
ggccctatta tacatgaaga catagtaatc ccccttcact tttggaagcc tcggagagag 36600
tttgagaatt tcaagttgaa atatcacccc ctttcacaaa attctgtatt taaggatagt 36660
atttttcaga atttaaaaaa attttttact ggaaacttaa tattacagca ttccccttca 36720
gggtttatgg tcaagctttt ttaaatatat gttttatttc tttaactggc agatgtttga 36780
aagatgagag taggattaat cctcatatta atttttaaat acatctcatt cttccaaaga 36840
atgccgagaa aaagaaccaa ctctccatgt agtaactggc aaggaaggaa atagggctcc 36900
taccatggca actccctgtc agggatgctt agtgttgttt ctgtccaggt tcctcactgc 36960
tgagaacaaa tagccaacaa tactgagaga cggggaggtt tcttctggct aacagtttca 37020
gggatacagt tattgcagga gaggagagga gaggagagga gaggagagga gaggagagga 37080
gaggagagga gaggagagga gaggagagga gaggagagga ggcagctggt taaaccgggt 37140
ctgcagtcag gaagcagggg agccacacat aaatgccgag actacacttg ctttttcctt 37200
ttgctccact gtgagaacac agcagacctc aaaacacagc agtttgggaa ccaacacaca 37260
cgtctctttg tgtctggcaa ttgatgtaag ctccatggtt tttgcttttt ttctagctcc 37320
tttaattgat tgattgattg attgattgat tgattgattt ctgagactgg attttgctct 37380
gtaagccagg cttgtgtaga actccaattt tggctggcct ggaattggag aagttcatat 37440
tctcattata cagagtgctt aatggcaccg ttatgctcag gtcattcatt cattcattca 37500
ttcattcatg catgcatgca tgcatgcatg catgagatag gagttttctg tgtagctcag 37560
aatttccctc caacttcaaa ttctccttcc tcagctttcc tggcaatgaa aatacaggcc 37620
tgcgccatta tgcgcaagtt atattggctg ttgttaatat ttatgttagg aaaagaaaat 37680
agtctctgtt ttacatacaa tctacttgga atcatttttt ttttttaaag ttaagtcggg 37740
gtgaggggtg tgtgcaggtt aacaagcaaa cgcaattcct ccagctaacg ccaaggggca 37800
ccctctcctt cccctcggtt tctggagcgc cttgagttct ttccatctgc acaaagagcc 37860
cggcctcctc ccgggtgaca tcacaaaggg tcgttctccg ccccttcggc gccaccacgt 37920
gtgtccccga gctgagtggc catccgactc agtccctcgc cggccggtct aggcagcgga 37980
ggaggcgagt gcttgatagt ggctggaagc ttcgctatgg gaagtcgctc tttagcactg 38040
tcgcggctag ccctgctctc tggttctccg cagccgctgt cgttggagag caccgggagg 38100
cgcgggttgc gagcgcgcct gcttctcacc gcccgggcgc cagcgcccct gggcaggtgc 38160
tgagcgcctt tcggagcctc ccctgctgcc tccctcttcc gcctgggtgc ctggctgctg 38220
cagtgcacat gggctgctgg aggtagatgg gctcaccgcc cgtgaggcgg cggtggatgc 38280
ggcgctgggc agaaacagcc accaattcca gctgccgtgg ggccgagcgc cccgggcgcc 38340
gctgcgagcc ccgagctcgg ccatggggac ccgggcaagc agcatcaccg ccctcgcctc 38400
ttgcagccgc accgccggcc aagtcggagc cacgatggtc gccggctctc ttctcctggt 38460
gagcgatagg aggggaccct agggtggcgg ctacgttcga gcctgtgtcc gggagccggg 38520
cgggtcctcg ggcccgtagt gccggaggcg cgcggtggga ccagacgggt tggaagggtt 38580
ggttacaagg caatagccag accgaggagg actcctacta gatcgtgtgt gtgtgtgtgt 38640
gtgtgtgtgt gtgtgtgtgt gtgtgtgtgg tgagctaagg ctagtgagtg ttaaagaatt 38700
atttttcttg caatctggct gcttgaagga ggcgcgagag gtgtccgcct cgaggtcctg 38760
cgcatttttg ggtttttgcc cccgactcgg cctatctcgc accccaacac ccagcctcac 38820
cccaatatca ttcgctgcca gaccctcggc gcggtgcgag gcccgagtag tcctgtcagt 38880
agccagctgc cggttgtggc cgctcctttg tcgctactgc aatgtcatgt ccggatgcta 38940
ccgcagtgga gacagccgga tcggtgcgct ccggacgcga gcaaccgctg catgcttccg 39000
cgcgcgaagc tttccggagt agggcgcagg ccaccccttg cttcagcttc cttgcttctc 39060
tcctccctct tagttcagat gggtcctgat ttctgcaagc caaaagaaga agaagaagaa 39120
ggagcccggg tgggtggtgg gggtggggtg ggagggggag gaggagaaga aggacccaga 39180
gacccaggcg cctctaaagc acaggcttgg agccaaccgg cgctgtggct ctcagtcgag 39240
ggggagggga aagagctaca taaaggacga ttaattttcc ccatcctttt cttatttctc 39300
cctttctgtg tttagacatg tcaccaagca agatgatgca ggctctctca gcacccaaat 39360
ctggggcgtg cccggattgc aatcctccat cactttatct gatcaaaacc tgacatcatc 39420
ccttatccaa aacttacccc cagctggccc tttatttcca atattggggc caagtgggga 39480
attaggtgga agaaaatttg aattcaaacc cttgagatgc tataaaccaa tcatgtcttt 39540
catccctgca gggaggatga aggttgttag ctaaaaacta aacaaaaaca aaaaagagct 39600
tgttttcatg gttgggctgt gtaagggaag gcaggcctct tgtctccttc ctctaaaggg 39660
cttactgcct ggccagccaa gatctactgc ttccatccca aggcatgaca gttgctatgg 39720
cctgggaatt cattctacag acattctggt tctctctgtc tctctctgtc tctctctctg 39780
gctgactctc tttctgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg 39840
tgtgtgtgtg tgtgtttagg gagagagaga gagagagaga gagagagaga gagagagaga 39900
gagagagaga gggctaaaga aagtttgttg ttcttagcat ttatgaggta aatctcagtg 39960
tcccttgaga gacgcttttc tgtcttttta taacaatggc aaagtccaag ccctttaaac 40020
aagtgtggat agtaaataat cagagagtct ttgggaccgt ggacttgaat tgacagtctt 40080
agattgaacg agttcaagga agcactgatc ctaatgacct gagttaggtc ccttgctgag 40140
ttccctccaa aggtcttaga cctgcttccg tgatgagcat atactgccgt gtgtccctgc 40200
tccacacaga tacaatcctt atacaatact tatagatcag tccactcaaa tccaatctaa 40260
agttagtgct caatgtatag tcgtaatctg gaattatttt ttaactttta gcctgatata 40320
taggtccttg aaggtctcag catagtaaaa ccatatgctt taagtaacca agaaagggcc 40380
tagttctttt tattaaatga tcaaactcaa tgtacccaca gattgcaccc agatttgcaa 40440
ctgatgacct acagtataag tttgacagtt tgatgaagtt tatgaaaggt attttagaga 40500
caatctcaag gtgacgatgc tacagggttc cttgatttcc tggtaactat ggcaaaaggg 40560
ctttctttaa attgatggag taggaggagg gtgagctgac catcctggag tgtgggaata 40620
ctccaggaaa catcaggagc tatgcaatga ccttctccat ccccactttg gacggtccag 40680
tcatcaggac gggccctgtt tctgtataca acagtgatct ggtgactctg ttctcaggag 40740
aattggtccc attggtaatc ttggccacat taacagcaga caccaggtag gacagctcaa 40800
gtaaacatgg tgtgaggtac ctagaagaat aatgggggat acaggaaggt taatgctatg 40860
tatatacagg gtggttagat aaagaaataa tgatggcttc caattgccct tctctcattt 40920
ttttttcata gcagtctttg ttgttttttg tggctctttt ttttttctat cagcatgaag 40980
agcttactat aggctctgat atgtatgcct atcatatgaa cttgtcaaaa gagcagcgag 41040
ctaatttata cagaatatgc cactatccct gtcaaacggg tgtcacctcc attctacgga 41100
tgagaaaata gtctccaaga atcttactgg tctgttgtag tatgtggtga ctctgggctg 41160
gaactccttg gctcctactc tctctcaccc acgtaccaca ctgcccgttt cacaacttca 41220
agttgtttgg tgagtgtaag gacagagaag gactgctggc aggtagctga gacggtggct 41280
tgattaattg gggaatataa gtgagacgtt cacaaggacc tttggagtga gtcagtctag 41340
ttgctggcat ttctattgct gatgtgttga tgtgaccgtg tcatgtttgg aagttactca 41400
caaactgaaa tgcagcatac acgttccagg ccaaagttct gtaaatgaga catttagatc 41460
tgtagtggtt tagggattgt cctagaagga cttgcttact gcaatgctgg atgcagtcag 41520
aggtgcctct tgcctttagg gagcttggtt tgactataca gatagactga ttgcaaggga 41580
tggtcaaggg aggaaagcaa cttccttggt aaagactttg gatttggagc tttggaaact 41640
gctgttatcc acggactgag aattcctgca ctgaaggcac agggaagaag gcatagcaga 41700
agaaggagtg gaaagattct aaaagccaga ggaacagaag ttgctgtgag atcgtgtcac 41760
ctggaaatgt ccgggaagct tcactcatga agtttcaaca gcatggctgc gtaagcggga 41820
tctgatcaga gaacaccagt ggacaggcta acacagaagg gggaacttca tagggcctca 41880
gccctagaca aaaaattaga aatatgggct actaaggaat atatatgtgt gtgtacaata 41940
cgtgcatata tatacaaaca tatgcacaca cacatatatg tatgtgaatg taacacatgt 42000
gcatatgtat tatgcacatg tgcacatatg taatagcaat tgaaaataac gccatgaatt 42060
tgagtcgtgc aaggctggta catgagaggt tggctgtcga gaggaaaggg aaggaagaaa 42120
agatttccac acaagaggtt gtccagctgt ctggccatcc cttttctagg cagctggcat 42180
ctcaccattt ctggtcacca aaagaaaaaa taccttattt atttatttat ttatttttct 42240
tttgccggtg ggaaatggtc agacacatca tcagacacat catcagacac atcatcttgc 42300
ttagagggtc ccaagtgtta ctgttggcca ctgctcctga gttctacctt ctgacttcca 42360
actatcacag aaaatggcta tctgcctggg caggagtgta catgtgaggt catctggggt 42420
ggggtggggc actcaagtcc tagccttggt gacaaatcca attagaatat gaaatcagag 42480
ctggcgggca tacagagggc tctctccctt tgatatactt taacacagca tcctagactg 42540
tggaagctgg gagggaagct aagctgttac tgatctaaca ccccacacag cttggctgag 42600
ggaaagaaca gcctccactg cggaagtgac tatttttcat tttaccaaat ctacatggtg 42660
cagaggcggg atcctaagca gtggaagccc agtgatgaag tgggattaga accttgcgtg 42720
gcatgaagct catttctgtg gcttataaaa caagtggccg gtgtcaatgg atcaatgggt 42780
gagcatgcta gaccccgaga gagacacaga tgtgatgttc acatcttcaa aatatgtagt 42840
ctgtcagagg aggaaaacac ttctattttg gaaaactttc caatcttgga atgatatatg 42900
ctagttgatt tatgggaaat tgttaatgag gaggaacaag taatccagat cttctactgg 42960
attgaacaac tcctgatttt taacccataa gttatcccca caaagtttag agtagggtca 43020
agctttctca tttggactta ctgtatatct ctggctatca gatttagtca cagacagaca 43080
gacagataga cagatagaca gagtctccag gacaactaag caattaagat gaatctacaa 43140
gaaaaacctc tgtagttaca cgggcacagg tccactgact acttatacat ctggacaatg 43200
tctaccaatt agataaagca accatagttt gccttcccca gtggtcaggg gtgggtttgg 43260
cttcagagct gggtctagtg agtagctggt gtcttctctt tggaatttgg ggacatcaca 43320
tcttgacttt tgcacttgac tccatcttga ggagaggcaa agcttcttgg gaggcttggt 43380
agaaaagctg caaattggct ctgtgctaac tcagccagca ggcaaactat aattggctta 43440
cataaagttc acgattatta ttattatttt tttttctttt ggtgacggga aacggtgaga 43500
tgcatcatca gactattcaa gggccaggac gaattgagcg acttttcctt gcgtaaacag 43560
ctctgcctat tttccagaaa gcactaatac tctgttggct tgcttccccc ctgcacaggc 43620
ctggcaaatt gcggtaatgc caggtcacca ccagcaactt cttggcaatc tcaggtgctt 43680
ctcttctgtg actagaaggg cccagattaa ctggtgggta tccggtggtc atttggagtt 43740
gagtccattt ggagcacgag atgcagatat attggatgga cagaatgaca actgaagcca 43800
ttagtaggag cagcttggcc cactgagtgt cagcaggagg ctggacttgg ttgtttctgc 43860
attagaggcc actgagttgt gttctttagg aatagaggcg agagatggtg gataaacact 43920
ggctttctcc agtgtttata tttgtcaaat acctaaaaat caacaggatc ttaaattggc 43980
ttgaaggctg ccacctggtt ggacagtgat tattaacctg gagggagact ggcagatgat 44040
cagaaatatg ggtggggcct ctgcttatgg agagaggttt tgatgaccgt gctgttgaca 44100
gaaggcagat gcgcaatcaa cattcatgaa gagtgctgaa gtcggggtcg tgtgtgtcct 44160
ggttggaggc aacatgtcta tagtgttagg aaagttgtgc tcagggggct ctcaggaagg 44220
tgtgggatgc agcaggacct cggtaagctg gcaggatgct gccccatgtc ctttgatctt 44280
ctcttcagaa tggttgcaga ctatgcatga ctcgtcgcag gtctaagaca aataaaaaga 44340
attggagaga agcacatagc caaatcagaa cacggctagt agagctatga gacaggccta 44400
tatcgtgttc cattcgctct ctgcaaccag gatcactgta gtggctctgt tgcttggcac 44460
catttgcaaa atctgcttgg agggaagagg aacacaggct taatagagtt agacaagaac 44520
atggagcttg tccatgtgcc ctggcctcaa gagagcagct gtgaaatcag cagagctcct 44580
gtgttagtgg cctttggagg aggactaagc aaatggctgc taacccttta tattgggatg 44640
ttatttaatt tatatattat aaaaatatta tgtaatatat tcattcatat actatagaaa 44700
tggttcttat tactgcattg aatatcttct gtaaagcact acagtgtaca ttttacaagt 44760
cccagacatg acagctttag tcccatttta cagaatccag aataaggttt gatagagttt 44820
ttgctcagat atctgcccat tattacgttc tggagagagg gatgaaatct agctcagcat 44880
agtttcaaac acttagctct ctctgccaag agagaatgga acaagtgaac agaatggttc 44940
acttcaactt cccatacata cgtttgttta ttctaaaggg aatggtttta cccaagaggt 45000
gaacatgccc gttttattct ctgagtttca cagtggtacc tgaatggttt gccaaaacta 45060
ctggtacttg tgagcatggt gtgtgggagc tgaaagggga gggcgtggag acattgggcg 45120
aacactttcc tatggtgtga ctctgacgag ccatggtgcc acggttgaga tggaaagaca 45180
ccccagcaaa ttgaaacttt ataaataggg aacgggcgtg ttggctctcc tgcagccctg 45240
ggtcactttg aaaaatattt gcttaatgag taacagcgag gtgtgggctc cactctgctg 45300
tgtagttagt ttctgctcct ttagtctgag cacctgagga cctgctaggg tctttgctgc 45360
tagcctgact ctttgtatag gataatagct gtaccagcaa tgactagcat ctgtccacat 45420
ttcattccgg ttctcattcc atggtttgag tggttcgtgc taggaatgta gtggataggt 45480
tgccacagtt actggagcac cctcataaac aagccgttag agaaaaaagg agagagcttc 45540
atacatgcat aggatacgtt ttgatcaaat ccacagccct tcactctctc tctccccttt 45600
caacttctcc caacagcccc ctctccccat cacctttccc tcccaatttc acgtgctctt 45660
tctctaaatc cactaagtcc gtgcacctgt aggtacgtga gtgtaggact atctactgcc 45720
gcatggatag cctgtcagga gccccatccc caaagaaaat ggagtcttcc tccccgaaca 45780
gccatcaatt cctaacggct tctcagctag gggtaagaat ttatgactcc atctcctgcc 45840
cacgcaggct tttgactggc ttggttttat acaggtcttg tgcatgcagt cccaaccatg 45900
cacacttcat gtgtgcaggg ccctggcatt tctagcaaat actgtttcac tctaatcaaa 45960
tgatcctttt ggatcttaca agttttctcc tcttctttga gatccctgag ccttgtgggg 46020
gaggggctga gatgcatcgg tctcattttg cacctaacac tccaaggtat tctaggtatt 46080
ctattctctg tccgttgacc aggcgtaggt ctctctctct ctcttttttt ttttttttga 46140
ttcccatctt ctacactgtt ggaaggggag ggagctatgc tgattaaatg agctttgaga 46200
tctgttgaaa tcccaatttg tagccttagc agacaaaagc tggaaggaaa tgatgtatta 46260
gtgccagaaa agagattgga gttctggtct cccaaaaacc tttatgacaa gaccactgtc 46320
tgatttcact gcagacatgg ctagctagct ctgctcagca aggactcaga gaggcagcgg 46380
ggtacgaacg agacaaggaa acttgcaggc aaagatgaca ggttttcaga acagtccaac 46440
ttgtatgttt gtgcttattt tggccccact tttctttcca taattatttc cctttctcct 46500
acaggggtat atttgtgttt ttcatcaact tactaaagcg taaagactat ctactaagga 46560
acaggcatgg ctagggtgtg ggtctataga agtgactaca ggttatctgt agtctcccct 46620
tggagttcgc agaaaacgtg atgtttcatg gtaatcatca taaagcagaa gggagtggat 46680
ttcagtggaa gggaccggta tgtagaatag ccccagtgta ggacagagtc tgtgtcttca 46740
tctctgacca ctatgactgg gaagaggcag tgggactgtg tgtcgtggga cccttgaaac 46800
tatgaagatt cgttcagtgc aggagaagca gggtaataac atggcttgaa acattctttt 46860
tttttaaacc ttatgtatct ccagatctca catctccaga aagttcctgg cagtcttgag 46920
acactaatat gggttctggg aaccaaatgc aggcctctgg aagaacagca agtgcttaac 46980
cactgagcat cactcccacc tgccaacatt gaaaaaagaa gttttaatta atccttagag 47040
aattccattt agtgtatttt gattccattg ctcctgaagc tcctcccaga tcctccccac 47100
cgcttaactt acccaagttt ctctccctct cgcgcctcct tgcattgagt atagtttgtg 47160
ttggctaact gcttttgggt atcaggccac aatcaataag gaaaaaacaa aacaaaacaa 47220
acaaacaaac ctgtttctca tactgaggat ggaacctagg gttttcacat attgagcaag 47280
tgctctacca ctgagctgta ctcagctctc agatcgctcc agaagcctgc tggaggatgg 47340
aagctggagg tcagctgctt tcacagggtg gagatcacag tgccggggat agtggcggtg 47400
aagatgaatt ttctagaatt tactggtggt aagatgggag ggggtcaggt ggtctcaaag 47460
gaggcggact cctaggtgcc taaattgaag tctgtgattg gaaggatggg ctgggggcgt 47520
ggcgggtaga attagaaccc taagcttctg ctgtgtagtg agttaagttt gaagtgtcgg 47580
cgatgaacat tggcttgggc cttgattttg ccattttgaa atagctgact ctctgcaggt 47640
ccgaagcgca ctgagccatc gcgactgtcg ccaggcattt gggctgccgt ccttcctccg 47700
cagcatccag cagcacagac atctgtgtgt agagcaatgc tctgttcccc cttaaggttg 47760
cttcctctga ttgcattccc caaagtggca ttgccaggtc agaggaaacg aatgagtggt 47820
ttttatggcg ttcgctgcag attgccagat tgttttttag gaagacaatc aattcagcca 47880
ccagccacct ataaatgtgc tttctagtcc atgaatctgc cgcgacggga ctttctcatt 47940
tcaaattacg tatcttcttt ttaattcagc gatgtaagga cctttggtgg tctctgtgac 48000
agtttagtca tttctagggg cataataaac ttacttgcat gatgcttgac ttttaatgac 48060
tcatggtcct tctagcgagt agaagttatg ctaatcttat ttttatcaat tctacttatc 48120
attctggtta taggttctta ctagctgtaa tggcattgct ttatattcta ttgacttttt 48180
acgatcatgt ttacgtattt gctttgtttg tgtgcacgtg ggcatctctg tgtcacagtg 48240
catggaggtc agagacaatt tatggagtct gtgggtcctg gggatagaat tctctacctg 48300
tcaggcttag tgttaagccc cattgcccac tgatccattg caccaatact gcaccactac 48360
tgtactctac tataatatca tgaaaaaaat aggattgtgt tattaaacct tttcctttct 48420
gggtctgaga atattctttt tgttttgttt tttggatttt tttttttttt tttttttttt 48480
tttttttgcc cattttgtta ggaattcatc ctttgacagg tagttataaa gaatcctaat 48540
tgctttgaat tttataatgt tattggttga cttgttgata tttctggata ttggtgtcgt 48600
atatgtggtg ggaatcccct tggtgtgttc tgaaggctat atgtgcgtgt gtgtgtgtgt 48660
gtgtgtgtgt gtgtgtgtgt gtgtgtaatg gattctgtgg gtaaacacac aggggagtgc 48720
tgggcccagc tgattcacca tttcaggctg ttcttccgtg gagtcacctg ggacaggtga 48780
tagctgatat attaattgta cccgttcagg agaagatata cggagtattt tctgaactct 48840
agactagggc atcagagact ttttctgtaa agtgctgggc agtacggtta tcttatgata 48900
tctgtggtaa ctacttaatt ccacctttgt gcaagacatg tgcagacaat gtctcgaaga 48960
gtgagtctgg ctgtgtttca ataacacttt atttgtggat aatgaaattt gagtttcaca 49020
cagttttcac tggtgctata ttgctactca ttcattcctc ctcatttccc agctgtcaga 49080
ctataaaact gttgtaggcc tgcctatagg ctatacaaaa atagacggcg atagagtcca 49140
gcctgctttt agaccagggc attaatattg tgtgagagca aattggggca actcactttg 49200
gaaaaccctt acttaatcgt gttctgggca tctaaagtga gattattaat tgtaaatcct 49260
ttctatttta ttattatttt ttgttataag ccaaggttta tttcatttta attaattaac 49320
ttactttgag gtagtgtctc tggttgacta ggctgaccca aggctaacct tgaattgcct 49380
ccgttttaag tgctgggatt atggtgtgtg ctggtctcgg aactcaccag gcaggcgctc 49440
aaatagctga gccagccaca tccccagaat cccaagtgtt tgcttgtttg tttttaatat 49500
agtgtgaaaa gtagccttgc tttctcttgt ctttatcttg acgtctgctt taaaacaaaa 49560
cttctacagt gtgctctgtg ttcggggaag tgagtttcag gattataatt ttttattttt 49620
taacagtatt attattatta ttggtatttt tgagacagag ttgctctgtg tagccctggc 49680
tgtcctggaa ctcactttgt agaccaggct ggccctaaac tcagaaatcc gcctgcctct 49740
gcctcccaag tgctgggatt aaaggcgtgc gccaccacgc ctgcataatc ttttattaaa 49800
ttaaataaaa gaaataacca atttttggtg tttgaggaag aatatcccta tggaaatcag 49860
cttgaatagg aaatcagtgt ctagcacaag ctggccttgg attttgtgat gttcccgtct 49920
ttccatccta aattctgtgg tcataagtat ggaccaccat gtaaataggc aagtaccact 49980
agtacatagg catgcatcca gatggcagtt cttttcttat ttgcttgttc tgagccagtt 50040
tgggtgtgga tccctgcctc actttgaata cactatgtat atccatctgg ccttgaactc 50100
actaagtaca ccaagctggc tttgaactca ctgcatacct caagctggcc ctgaacttgg 50160
gatattcctc atgcctttgt tcccaaagtg ctgggactac agtggatgcc actgtgatgg 50220
agttgggtta cacctttaaa caaaaaagtc tagagtttgg aggctggaaa tgtaacctgc 50280
ctagcacaca gacaaccttg gacttaattg tagcatgaca aaacaaaaca aaacaaaaca 50340
aacaacaaca aaaacaaaac aaacagcaac aacaaaaaca aaacaaaaca aacagcaaca 50400
aaacaaaaca aaaaaggaaa catttctcaa atttatactt aaaatagaat tgaaatgttt 50460
taaaacattg tctattcaca ggtaataaac ttaaagtcta gtaaaataat aaattggtgg 50520
ggtgataatt tcccaaactg gtattccatc cagcaattac catgtcagac atgttctcca 50580
tactccttct gtgtagctaa ttatcaaaac aacttagaat ggccgttgtt attgctgtgt 50640
ccattttaca agcgaggagg tagaggcttg gacgttggct ccttcccagg ttagaaagat 50700
agaaaaaaaa aatgtaattt tcttcagctt aggaaccaga ttcaccagct gacactcaca 50760
gggtgtcttc aattcacacc cgaccctatt tgcttcaaga tagctaccgg ttggaaggct 50820
agattccaca agacggactc taacggacgt caggtatcaa gagtaaaagt caggttataa 50880
cctgtgcttt ctgttgtctg actgtaagtc agagttccta tggctctcag ggggttcagt 50940
taacttgtaa gcatggcctc acatatctca gggaaacact ttctgaatat ggctctcttc 51000
tacagaaagg agacccatga taaagcatgc agaggaaggc atgcttaggg cagccatata 51060
aggagcaccg tggagctgtg gagctactgt gtctgtctgc cttggacacc gtgagctctc 51120
tgaaccttgt cctttcagag ttttatggag atgctatttc ataggcacaa tttactacgt 51180
cattagacac tggtgactaa acttaacctt caacccctct cctcatccca gagattgagg 51240
tagaactgaa agtagcaagc tgaatataaa aaccttgtgt gttctgacca ctggtctcca 51300
tcttggtggc accctctcag agcctccgtc ccctgtcatt ttatcaccac ccagaagacc 51360
ctaatcacgc tggctgtgag cttccctact ttgtaggatc catgggaaga gaccacatct 51420
atattcctta ttatcacagg atcgcggcca gcagatacct gggcgagcag ggcgtatgtg 51480
gtacattcta ggcttaaatg gtttttcctt atactttgaa gcctcagttg ctgcactggc 51540
ctgggttgta tgctcttcca gacatgccca gtcagcatga agttgcatcc ttccatcatc 51600
tactgttttc tatgacatac tatttcactt attactcact gggcatccta ttggcatctc 51660
tcagtaagca gagaataaag aaattactac tgtgttggag ggagacgggg ctgtggtcca 51720
gtgactgatt gctgtatgca ctttctcttc tgcattgcgg gttccagaga aaacagctcc 51780
taggtgaaat cttccctgtt tttttcctct ccagtgtccc ctgagcttgc ctccttctgt 51840
tcctacagtc agcacattct ggctctggca ttctctatag tcaccagctt gaaaaacagt 51900
ccctgcttcc tttgctttgg caataggaga cggctctccc tccttcccat tcctctcatc 51960
cctcccatcc tcctcttcct tcatctctcc ctctcttcca tccttccttt cttccttcct 52020
ctttccttct tttcagagaa ggcagtagaa atgaaagagc caaccaagtt tatataacat 52080
aactggaaat accctgtctg tgatttgtgg aacctttgtc cttgaaacgt ttgtttgtat 52140
gtatcccacc tgccccacaa cttcagatct ggggaattat agccatccag tgtttatatt 52200
acaaattaaa aatgatggcc cagctatctg gtcaacaatt ctgagggctg agcagctctg 52260
tctttgtcat caggtatcat atttcatagt catcctcata ggcaaacctg attaccttac 52320
aatctctaca gtaactacac acacacacac acacacacac acacacacac acacacacat 52380
atatgtatat acacacacac atacatgtgt gtgtgtgtgt gtgtgtgtat ggaaaaattc 52440
tatatcaaag tccagagcaa ttttcctgct tcttactaag gaaaagcagg tccacctctg 52500
tcttaagttt gctcgtttta taatgaaatg ttactagaac ttgagaggaa atgaaagtaa 52560
tgtctgcctg gtgcagggac gatggctcag tgggtaagat gctggcttac aaatgtgaag 52620
agatttgagt ttgaatcctt agcactcatg taaaaaggct ggatgtggtc ttgtgagcac 52680
ctgtaacccc agcattatgg aggctggaga caaggaggct tgctggagct tgctggctgc 52740
cagtcttgtt aaaatggcaa gctccaggtt tgatgagaga gccctgtctc aagtcaacga 52800
agtggagagc gatggagtag gacactctac atcctcctcc ggcttccccg tgggcatgtg 52860
cacctgtaca cacacatgca tataccacac acacacacac acacacacac acacacacac 52920
acacacacac acacgctaac gtcaatggca cagatctgtt gtaaccttta agctaccaag 52980
ggatctcttg tttatctgaa ggatgaggta atggaagtgg aattgctgaa caataagtag 53040
atgtctacat tctgacatgg attcacacat ccgggtgctt cttgtcttca gtcaggccca 53100
cctgtgctgt aaactgcaag tgacacatca taggtgtgct ataggccacc aggatgcaca 53160
gtgagactct ggaagccttc acagtcagtc acctgcacca agtgctgctc tccacttgat 53220
ctctgcttct ctcgtttaag cttctaatca ttcaataaac acttgtagtg tttttggttg 53280
ttgttgtttt taaccaaata cagtttgaga cagcatgctg atacttgatg catctatcca 53340
ctgttgtagt tgacattcct tttttttttt gattagatgt tttctttatt tagatttcaa 53400
atgctatccc taaagttccc tataccctcc ctccgccctg taggtgacat tcttagatac 53460
atggaatttt cataataatc gcagtttaaa cacagagaga atctaacctt cttatattgc 53520
ttataatctt aagcacaaag tgtaatcttc tctttttttc tttcttttaa atgagagaag 53580
aatatttgaa ctctttagta tattagcttt ttattttgag tatcacgaag aagctaattc 53640
ttagaagcca attatagttc tgttaagaga gagtaatggg gggctggaga gaaggctcag 53700
aggttaagag cacaggctgg ccaggcatgg tggcgcacgc ctttaatccc aggacttggg 53760
aggcagaggc aggtggatct ctgagttcga ggccagcctg gtctacagag tgagttccag 53820
gacagccagg gctacacaga gaaaccctgt tctgcattat agattccagg gaagacacac 53880
agagtataag tgtgtaagta agaaaacgat gacaaccata tagggaaaag aagaaaccga 53940
ggagggcttt acaattgggg atgggaggca gggagagcac ccaggaggaa gtcttgtctc 54000
tctggatgat tttgcttttt ctcagacgtc agggggaagt gagagtttga agccgagtgt 54060
gaaggaacca gattgagcgt gtgagttaga gtgggtggag agagagagag agagagagag 54120
aaagagagag agagagagag agagagagag cgagcactct gctcataaag aaacttatgg 54180
gggagaccag gaagtttcta tgagcagctg gtctctgcaa tgtttgtatt tctttagatg 54240
cccatgctgg gagctggcag atttcaccta taaagggcca agtgataaca gtaagctaac 54300
tgaggtttct gggcagaatg gtctctgtca tagctttgtc gctttcccac agtagcctga 54360
aagcagccac gagtgctagc tacatcagtg tctggactct aggaagcttg tttataagac 54420
gagctggtat gttggcattc ctttgctggc ccctggcttg aaggatggtt tgcttattat 54480
tttcctagtg ttcattaggt agttgagcaa gtgaggaagt atagtctgta cagtagtccc 54540
tggccttgag ctgcttataa gcattaagga aagataagta tatacactta cggtactgcc 54600
aaccaacatt aagagacact atgtaattag acgctggtac aatagacaga aacaggaagt 54660
gcgatgggct agttgctcat ctgcttggca tctgggtgtt tagaaagaga tttaaaggct 54720
acataaggat ggcaggattt gacagaatca caacacgcag gagggtagaa ttggttgaat 54780
attactactg agttcaacct gctcatttcc taagtgagca acccaggatc ctgttgactt 54840
cccaacaggt tgggtaagaa catgccttct cttttcaaaa tctttgtcca gttcttttcc 54900
tgactttttc tgcttgatcc acccagggat gtttatgtac gtatgtttgt gtatatgttt 54960
tatattgtta ggggtgagag aatggggtcg ctccaggtta tcgattgcat ttaggatgtc 55020
aaaagactgg gaccagggtg atcgtgtctg ctacttggac tgatgtggag agaagagaag 55080
ctaggtgagg ggtatgggag ggaagaagca gttgtgcaca atagaaaact ataccctgac 55140
ctatatacat gcaagaaagc agtcaatgaa gtcttggtgg gaagaccctc tgaagtaaga 55200
catacccatc ctgttggttg cgtgcctagc ctttaatggc taagccagct ctgtagaata 55260
tgctcattct gttgaagaac tctgaattgt tagagtgaga cagtttgtat gttaaaacag 55320
acaggtcttg gtgatgtaac agaagttagt aaaagagaaa tcacagagca acatggttgg 55380
ctttttttcc ctttgcatac acaaaaccaa ctcaaacaag agaacgggga agctgagaat 55440
ctgtagttcc aaattgctag gactattaca tagatgttta ttgagggggg gtggaagtaa 55500
aatgctaata tcaagttatt taaaaatgcc aggttaggta gagaaggggg tgactctgac 55560
tgtgagattg ggttgtatcc aaaatgtggc tcaggatcaa agaattttac agtcagaggg 55620
gtcttggttt agtgttaggg actcaagagt tagttagata ccagaaacac tcagattgat 55680
taaaaaggca agaaaaaaaa aacctcacag ccaaacaaaa taagttcctc accctgttgt 55740
atactcacaa cgatctcaga gataagacga ggtacatgaa gaaagtactt tcaaaaatca 55800
tctcagacag tattattttt tctttttcca ttttcatgtg tgtgtgtgtg tgtttgcgtg 55860
tgtctgggct ctcatgtgtg gttccatgtg cacatggagc cccaaggttg acattgggag 55920
ccattctcaa ttgctcttcc ttcctatttg gcgaggcagg tgcttaagcc aaacccagag 55980
ctcagtgata tgtgtcatct ctctagcctg tttcttctag ggatccgctg acacctctgt 56040
gatggaatta caggtagact gatgtatcca cttgatacac actcttcccg ggcaatttca 56100
gttttatact caaaagccgg aaactatgtt agatctctct gacctgtctt agccatgtct 56160
atacacatgg tgggggttgg gagaggaatc aagggtctta attggaagga cccagcctcg 56220
gttttcttga ctctcactat ccatgacctt gtctcccctt tcccatttgt ttgtcttctc 56280
ctctagggtt agctttcact ataatctttt tatattgtgc aggggccatc tttaaatatt 56340
gtcttccatt tggtctattt ctgcccagat ccatggggtt agagggaaga gctaatgtgt 56400
gaggtgcaca tatgtgcatg tgtggatgtg cgtgcgtgcg tgcgtatatg tgtgtgaact 56460
atgtatgtat gtatgtatgt atgtagaggc atgttctcag gtagctcaag tgactctcaa 56520
acttgacgtg tagccaaaga tagccttgaa ctcctgatcc tcctacctca gcttctcaag 56580
tgttgggttt acaaacttgc gccatcacaa ggggatattg ttttgttttg ggacaaagtt 56640
tctttatgta gctcagactg gtctggatcc tgtgatcctc ttgtctgagt ctccctagta 56700
ccggcaagta cttccacaac ttggaagggg aaactcttgt ttagatacag tttttccttc 56760
ttcttcttta aatagcacag tgggattagc tattgactct ggaattggga gagactttag 56820
aggaccctgt agtcttgttt gagtaataag ctctgctctc aacaggcctt ccctctgatt 56880
aggctttgca aagcagagct gctctgtttg agacagaagt gagggggctt ggagcctacc 56940
tcccattgct ccttggcaag aggcagccct gtgatttttg tccagttcag cgcttgcttc 57000
ttgtcccact ggtttcttcc tccatccact tcgctaaaca cagttaattc acactctcct 57060
ttattctgtt tgcaggagat agatgaggta attttatagg tcagcattat agtcccttaa 57120
aaactgataa aggagccagg catggttgtg caaactagcc cagctccgtg gctcatacct 57180
gtaatcccag cagcaactgg agagtctgag tcaggatttc cacgaggcca gcctgggtta 57240
taaaataaga ctctatctca aaacaaaata tcttcaaaat aattttaccc ccacgaaatc 57300
aagaatccca aatggagcaa gcatggtata gagtgtaggg aatgtgcagt tgctgggtgg 57360
ggtttgaaca cagctaagtg accccaacaa gtcagacatc aggaaagaac ctaccatccc 57420
tgtcttagaa caaaagtctg gacccttgtc tagtctggtg ggtgttgtca gcaatgtgca 57480
cactcagggt ggctccctgg atcaggagcc ctgggtgggg aaggctgggg ttgaggctcc 57540
atttcctaga gctttgtgta tctccccagg gtgcacactt ttgagtctac agtgggggtg 57600
gggcactaat cttgtactcg ggctccattg gacagatggt ttcctccacc ctgggcatct 57660
gctgaactcc ggatagggtg tctgggctgg ttgtgcaagt agagggagca ggaaaaggaa 57720
gggccaagcc aaacgctgag agaggagact taccaccaag tagcaggatc ttctctttct 57780
caatttccaa tatgaaatta aatttcccaa caagaaaacc aaccactatc catcgccaac 57840
cacctctgcc cctactttca gactcagaag gaagaaaact aagtatatcg taaactctaa 57900
ggaggaaacc tcaagaaccg gtgagaggcg gggaagtacc ctggccccac ataactgtgg 57960
ggttgggaaa agaatagact ggggtcaagt ttcgagatgc taagaagaca gactcttgat 58020
caccttgcaa gcagtttttt ttctttttct tttgctttgt tctttcagtt accgatgtag 58080
ctgtaaatct gtaaatctag aaggaatttg ttcggtagct ggtagcttgg ggcagccatg 58140
attttcatac aaatttctcc atctcactga ggatggcaaa gactatcagg gccttcattt 58200
tgacagcccc agggaagcag tcactctagt cttttgctcc ctgcttctct ttcacagcat 58260
ctcaggactt ggaacttggg atacccccag gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 58320
gtgtgtgtgt gtgtgtgtgt gtggtttgtc cagacagggt gtctccatgt agccctggct 58380
atcttagaac tcaattggta gaccagacta gctccaaact cagagatccg cctgcttctg 58440
cctcccaagt gctgggatta aaggcatatg ctaccacacc caacgggtcc tccaagtttt 58500
taatctggaa gttggtgaaa ctctgacctg ctgggtgaag tttttatttt agaacatgaa 58560
cactgagtta ttcttgctgg acccaagctc aatgggtaga tttctcaatg gatgcctgca 58620
gggattgtgt ctatcggttg tggccttcag agactggaca aactgcgttt gaatctaaaa 58680
gcaccagctc cattgtttaa tgcacataac aggactgtca aaagtatggc tgtttgttaa 58740
aacaaaacaa aacaaaacaa aacaaaacaa aagtttatca tcaggtatgc aggtgctata 58800
gaaatgacaa ctttggcaca cacctccctc tttctgatgt caagttggtg tggtacccgc 58860
cagatcttga acagtggtga tgacctgtta ttgctgttgc tgttgctgtt gctctgttcg 58920
cctctgctcc tctatctgac acctctctta tttctttcag cttggattcc tcagcaccat 58980
cacagcttgg tacattctgg tgccaagtgt ggccattccc ctggctatcg ccttcctctt 59040
cttcttcatc tgtgtgtgcc gcaataacca gaagtcttca tcaggtaccg atttaaatga 59100
tccagtggtc ctgcagagga gagattggga gaatcccggt gtgacacagc tgaacagact 59160
agccgcccac cctccctttg cttcttggag aaacagtgag gaagctagga cagacagacc 59220
aagccagcaa ctcagatctt tgaacgggga gtggagattt gcctggtttc cggcaccaga 59280
agcggtgccg gaaagctggc tggagtgcga tcttcctgag gccgatactg tcgtcgtccc 59340
ctcaaactgg cagatgcacg gttacgatgc gcccatctac accaacgtga cctatcccat 59400
tacggtcaat ccgccgtttg ttcccacgga gaatccgacg ggttgttact cgctcacatt 59460
taatgttgat gaaagctggc tacaggaagg ccagacgcga attatttttg atggcgttaa 59520
ctcggcgttt catctgtggt gcaacgggcg ctgggtcggt tacggccagg acagtcgttt 59580
gccgtctgaa tttgacctga gcgcattttt acgcgccgga gaaaaccgcc tcgcggtgat 59640
ggtgctgcgc tggagtgacg gcagttatct ggaagatcag gatatgtggc ggatgagcgg 59700
cattttccgt gacgtctcgt tgctgcataa accgactaca caaatcagcg atttccatgt 59760
tgccactcgc tttaatgatg atttcagccg cgctgtactg gaggctgaag ttcagatgtg 59820
cggcgagttg cgtgactacc tacgggtaac agtttcttta tggcagggtg aaacgcaggt 59880
cgccagcggc accgcgcctt tcggcggtga aattatcgat gagcgtggtg gttatgccga 59940
tcgcgtcaca ctacgtctga acgtcgaaaa cccgaaactg tggagcgccg aaatcccgaa 60000
tctctatcgt gcggtggttg aactgcacac cgccgacggc acgctgattg aagcagaagc 60060
ctgcgatgtc ggtttccgcg aggtgcggat tgaaaatggt ctgctgctgc tgaacggcaa 60120
gccgttgctg attcgaggcg ttaaccgtca cgagcatcat cctctgcatg gtcaggtcat 60180
ggatgagcag acgatggtgc aggatatcct gctgatgaag cagaacaact ttaacgccgt 60240
gcgctgttcg cattatccga accatccgct gtggtacacg ctgtgcgacc gctacggcct 60300
gtatgtggtg gatgaagcca atattgaaac ccacggcatg gtgccaatga atcgtctgac 60360
cgatgatccg cgctggctac cggcgatgag cgaacgcgta acgcgaatgg tgcagcgcga 60420
tcgtaatcac ccgagtgtga tcatctggtc gctggggaat gaatcaggcc acggcgctaa 60480
tcacgacgcg ctgtatcgct ggatcaaatc tgtcgatcct tcccgcccgg tgcagtatga 60540
aggcggcgga gccgacacca cggccaccga tattatttgc ccgatgtacg cgcgcgtgga 60600
tgaagaccag cccttcccgg ctgtgccgaa atggtccatc aaaaaatggc tttcgctacc 60660
tggagagacg cgcccgctga tcctttgcga atacgcccac gcgatgggta acagtcttgg 60720
cggtttcgct aaatactggc aggcgtttcg tcagtatccc cgtttacagg gcggcttcgt 60780
ctgggactgg gtggatcagt cgctgattaa atatgatgaa aacggcaacc cgtggtcggc 60840
ttacggcggt gattttggcg atacgccgaa cgatcgccag ttctgtatga acggtctggt 60900
ctttgccgac cgcacgccgc atccagcgct gacggaagca aaacaccagc agcagttttt 60960
ccagttccgt ttatccgggc aaaccatcga agtgaccagc gaatacctgt tccgtcatag 61020
cgataacgag ctcctgcact ggatggtggc gctggatggt aagccgctgg caagcggtga 61080
agtgcctctg gatgtcgctc cacaaggtaa acagttgatt gaactgcctg aactaccgca 61140
gccggagagc gccgggcaac tctggctcac agtacgcgta gtgcaaccga acgcgaccgc 61200
atggtcagaa gccgggcaca tcagcgcctg gcagcagtgg cgtctggcgg aaaacctcag 61260
tgtgacgctc cccgccgcgt cccacgccat cccgcatctg accaccagcg aaatggattt 61320
ttgcatcgag ctgggtaata agcgttggca atttaaccgc cagtcaggct ttctttcaca 61380
gatgtggatt ggcgataaaa aacaactgct gacgccgctg cgcgatcagt tcacccgtgc 61440
accgctggat aacgacattg gcgtaagtga agcgacccgc attgacccta acgcctgggt 61500
cgaacgctgg aaggcggcgg gccattacca ggccgaagca gcgttgttgc agtgcacggc 61560
agatacactt gctgatgcgg tgctgattac gaccgctcac gcgtggcagc atcaggggaa 61620
aaccttattt atcagccgga aaacctaccg gattgatggt agtggtcaaa tggcgattac 61680
cgttgatgtt gaagtggcga gcgatacacc gcatccggcg cggattggcc tgaactgcca 61740
gctggcgcag gtagcagagc gggtaaactg gctcggatta gggccgcaag aaaactatcc 61800
cgaccgcctt actgccgcct gttttgaccg ctgggatctg ccattgtcag acatgtatac 61860
cccgtacgtc ttcccgagcg aaaacggtct gcgctgcggg acgcgcgaat tgaattatgg 61920
cccacaccag tggcgcggcg acttccagtt caacatcagc cgctacagtc aacagcaact 61980
gatggaaacc agccatcgcc atctgctgca cgcggaagaa ggcacatggc tgaatatcga 62040
cggtttccat atggggattg gtggcgacga ctcctggagc ccgtcagtat cggcggaatt 62100
ccagctgagc gccggtcgct accattacca gttggtctgg tgtcaaaaat aataataacc 62160
gggcaggggg gatctaagct ctagataagt aatgatcata atcagccata tcacatctgt 62220
agaggtttta cttgctttaa aaaacctccc acacctcccc ctgaacctga aacataaaat 62280
gaatgcaatt gttgttgtta acttgtttat tgcagcttat aatggttaca aataaagcaa 62340
tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc 62400
caaactcatc aatgtatctt atcatgtctg gatcccccgg ctagagttta aacactagaa 62460
ctagtggatc ccccgggctc gataactata acggtcctaa ggtagcgaca caggggcact 62520
gcattctggg aatcaaccta ctggcggggt gatttcattt cgtttctgac ttttgtgttt 62580
tggtgtgtat gtatgtgttt aacagagtgt atggccggtg agtttgggtt ctttctttct 62640
ttctttcttt ctttctttct ttctttcttt ctttctttct ttctttcttt ctttcttcct 62700
tcctgaaagt gaatgtataa agcctttaca atgtataact gttggaaaat gcccaccact 62760
aaattttttt ttaagttcca catattctcc atttttgcct tcttatatat atcttcaaca 62820
ctattctgtg cactttaaaa acttaacata aacgcagtgt gacttctccc atatgctggg 62880
tcccgagact ctcaacttct taaaaaccta atggcatctt gtgactccta gaagtagaca 62940
taagtctttc aaccttcaca cctactcttt ctgttttaat tattattgct atttgtctta 63000
ttgtttgtgc tttacaagcg ttcttgagga cggagggaat ctacgaccct gttgatgact 63060
gtaactctat tcgactttga gttgtcttct tcatgtcttg ttatatagtt catattcatg 63120
gctgaaactt gaccatactc cctagcgctg attgtatggt tttcgtctgg acaccgtaca 63180
ctgcctgata acttgtgcac ctcttaacgc tactatgctc tgggctggag aatgaaatct 63240
ttaagtcacc aggacttgct gtttcagtgg cttgacacct gggccaccaa agaactcgat 63300
cttcatcttt tagggacacc tctgctgcac cttggaaagc caaccttaag tgccagtggc 63360
actttatgcc cagctttgct ttgaaagata tctttcttgt tttttttatc cttctctttc 63420
tctctttttt ttaaaaatac acatagtcaa taggtccagt ctgccctcaa ggccttgctg 63480
ggttttcttc atcatccaat cactttcatt aaaaatggct gcagctgtaa gaactcttgt 63540
ctgataaatt ttcaactatg ctctcattta tctacctgcc ctctgatgct cagtcgtcag 63600
actctaatgc aaaggtggac gtcggctgcc tttgcgtggg cgggcttagt ggtgaggaac 63660
tgatatcaga aaaaaaatgc cttcaagtat actaatttat taataaatat taggtgtttg 63720
ttacttgtgt ggttttggta tatttactac tgaactttcg cctttccctc tgctcaggtt 63780
ctagccctgt tcatctcttg gggaaggatg tgtgttctga aacccttctc ctgtccaatc 63840
tgtaaatcat gaatattatt agcaaaagtc ccttttggag aggtacttgg aggttcactg 63900
cacagggctc tgataagcac tgccaagcct ttcctagtct ttcggagtta aaccttaggt 63960
aacttgatac ctgtaggacg atctgcacac attcacaggc ttctagccaa aacctcactg 64020
tccctgacga actccagagg gcttggtcag cagtgaggcg gatgtggtcc tgtgttggtg 64080
ggatatctca agctcactgc aggttttcct aagcttggac cccacctctg cggaattcca 64140
atgatcaaac gctagcaact ttaacatcct ctttttgtga gaacctggaa gctgatactg 64200
tgtatactgt gaccccccac gtcaacaact gggactgtct tccggtttca ctcatctctg 64260
tgtggcagct ttcaagatga acatccttgt ttcccttccc tcttgttggt gcatgccttt 64320
agtccattgg aagagagagg caggaggatc tttgattttg aagctagcct gggagtttca 64380
ggacagcctg gctacgctaa ctaaaaaaaa aaaaaaaaaa aaaaaaaaag atcacacatg 64440
cgcacacacg aacacacaca tacagagcaa caagaacaaa caagaatggg tcagttatga 64500
tgggggagga aacaggtttt gtcaggttct cactgtgtca gaagatttag aactgagaca 64560
tacaatccat tcattaatta ctagtatgtt aagtttatag tttattagta atttgggaat 64620
tttttattaa taacccaaat ttgtggtttt atattttaca acatataaag tttaattact 64680
ttattggatc tttaaatttg tcttaacggg ttcctattat tatgcccatt ttacagatga 64740
aattgggctt gtaaagctaa gtatatgaga tggtttctta tcactagaac agagtccctg 64800
aaaaggaaga aaagaaattc tttaagggag gaaacgttga tcttaactca tggtttccaa 64860
ggctttaagt ccatggttgg ctggctctgt tgcctttggt tgatggtaaa gcagaaacct 64920
ggtaagaaaa cacgacggtg gaaggttgct tacctccttt cggccagcaa gcagagagac 64980
acaggaagag tcttgggaca ggataactct tcagtggcac aggtccagtg accttctact 65040
agctagaacc ccctccctac cttatagtct attcagctat gaacacatcc atggtcgaat 65100
ataccactag ctgaagccca aacctccaat agatgagcct ttgtggggga cacttaatat 65160
ccgaagcata aaaccaagga atgtgtttaa gccctcactg agaaggttag caaggctagg 65220
tttgaatccg tgttgtgtat gttttgggaa gaagggtaga gcgagtggct gtaatctaag 65280
actgttcatt ctctttataa gatcactgac cagaaacctg ttgccacctg aaacagtggg 65340
cagaaacatg gcagtgaaat ctgtctgggt catgagtaaa gttcaaatgc aagttaagta 65400
agtggtacaa acgtaggcat gagaactaaa cattagcatt atatggtgat cccatgatgc 65460
atagctttcc cagaaggcaa tgcaccatca gctactttct taaagtaccc agagtcaagt 65520
gtgatggatg gcacacacct ggaacccagc actcacttgc aggctggaag accaaggcct 65580
tagggtcagc ctggggagag ggctcagtca gtaaaccatt tgccacacaa gcctgagaac 65640
ctttggatac ctggcacagc aaagtacagg gctctgtggt gcacacctac agtctccgtg 65700
ttgggcagac agagacagga agatccctgg ggcttgctgg ctggccagtc tagctgaact 65760
ggcaagcacc aggctcaggc aagtcactcc atctcaaaaa aataaggtgt aaaatggtgg 65820
aagaaggcat ccaatgtcca actgcagcct ctgcatatgt atgcacaagg tcatacacac 65880
acaaacacag aggaggagga ggacgaggag gaagagaagg aagaggaggg attcaacgtt 65940
agcctgggct acatagtaag accctgtctc aaaacagcca tatagctatt ggagttatag 66000
ttcattgaca tttgatcaac aacactgcag aaactgggtg tgacattgca tatctcccaa 66060
ttctttcact ccagaggtga aggcaggaaa gataaaaagt tcaaaatcat ctttgggtgt 66120
atagcaagtt ggagaccagc ctgggacaca ttagatgctg taaaaaaaaa caaaccaaac 66180
aactgaaata aaacaaaaat tcagcataaa atactaaaat atgtgacttt ctgattaaag 66240
ctaatgatag caccatttgt accatagaaa ggtcttctct ggcttgcgct tcttcctctg 66300
aggagtatag acagctgaaa aggaaggctg ctagtgtgag ggcagaggag acaagagagc 66360
aaccagaaga ataagaaaca gaagcaactg ttgggagatc caagccatgt tatgcaggca 66420
ggcaggagaa ggagtctgtt caccaatttg aaggactaag aaggagtttg tgacccctgg 66480
gaaaagacta cagactcgat ccaattataa tgaaaagatt tgttgattag ctgctagctg 66540
gatgagtaat ctctgagcca acttcgagat tacttcgcag aagggttacg gggaaggact 66600
ttaaaaggag aatatcacac aaagaccttc aatatctagg caagcaagta acaactgttc 66660
tattttgaca aattaagtga ttgaggcgac tcaaaacaat cttgggttat ctgtgcaaca 66720
agttacagag gcaaaaaaaa aaagttagtc ataacaagtg ttatgtatgg ggaggaaggt 66780
gtgactgagt cagggttatt ggaaatttat cttccgggga atggagttag agactagtgg 66840
gtatggaaat gaatgcctag cataaaacgg agcttctttc attttcttca gagagtaata 66900
tagttcctgt gggctgtttt aggctgaact caattagata gggctgcttt tcaaggagaa 66960
actgcttcaa ggagaggaag gagctgggcg agcatctgtg gttctccaac tttcatgtaa 67020
ataagtcacc cgggagtgag cagcttgttc tctttaaaaa aggctgattc ccacaatctg 67080
attggagagg tttgtggtga aattcaaaaa tgaagccctt gcaggttttt ggaccacact 67140
tagaaaacta tctttagaga atttccgttc ctgccaatgg ggacaagaac agctaagagg 67200
agctggttag actcgcacct tcagaggcct cctgtctacc cttttaatgt gcaaatgaga 67260
tacctgaagg tcctgctcac aggcagactc tccaggcctc ttctgggaaa gggcagctgg 67320
catcctgtgt tgctgccaag ctcttgggta atacaggcac tgctgggttt ttctttttcc 67380
ccgtgaaact gggtagtctg ggatgacttt acctttcagg aaaggggcag aacaaacaca 67440
ggagtcgatc actcatttca caggagggaa ggaaacacac tttgatgagc tgaagaaaca 67500
cccagaacca agcaaatctg gtcaaaactt acaactggtt ggggctgggc ttggtaaaag 67560
tgcctgcagc agaagcacgg ggacaggagt tcggatcctc agcatccatg ttagaaaata 67620
aggtaggtgc agtgctgcat gccccatgca tgctcccagt gctggggagg cagggacagc 67680
agaatcccag gggtttgttg gcttgctagc tccagggtcc atgagagtct gtgcctaaat 67740
gataataagg tagaaaggtg atcaagaaag acatagaact ttgggcacac aaagcctacc 67800
cctcctccag caggattgta taacagcagc agaaagaaag gagacttaca gaaagaaagg 67860
agactcctcg aagcccaact atttggcatt tgtgcagaga gctctaggga tgtagctttc 67920
aagggtggac ttcttcacga gcagttgtat ttgggttact catacttctg taagtaactg 67980
caagaaattc atctggacgc aagaagcatc atttctttgt tccgttggca gtgccctatc 68040
tgaggcaaat agacatttgc tgtgtctctc caggaaaagt cacacaatac acagtgaggc 68100
tgcctggcag aggaatcctg tttatcttgt ggtcaaccag aataaaagag acaagaaagg 68160
ccagagtctc agtataccct agaagaatat ttccccaggt aatcaacttc cctccattag 68220
gctgcacctc ttaaagtgtc tgctacttct aaatagtaaa ctggtcacaa agattagaca 68280
catgtccttt gggactcact tctgaactgt acccctgggc tatgaattgg tcactttcct 68340
gctgttatga caaaatatca ccactcaaga caatctaagg aaaaagaatt tgagcttcca 68400
cttttggtga gagagtccat aaagacaggg aagagatggc agctggaaca ggaagctaag 68460
cctcaatcaa gaagctgaga aagtgagctg ggagtagtga ggctatataa catttcaaag 68520
tgatctgcct cctccagcaa ggttgtacct cctcatcaaa cagtactacc tacttggtcc 68580
catcttggtt gcttttctac tgctgtgaag atcatgacca aggcagctta taaaaaagga 68640
agcatttaat tgatcaattt ataaacactt tataggggac tggaaaggtg gcttagtggt 68700
taagagtact ggctgttcct cttctagagg ttctgagttc aattcccagc accccatggc 68760
agctcacaac catgtataat gggatctgat aacttctttt ggcctgaagg cattcatgaa 68820
gacagagccc tcatatacat taaataaatt ttatgaacag cttataaaaa cgttataaaa 68880
cataatttca gagttaccct atgactacta tggcaggaag catggtggtg gcaggcaggc 68940
atagccatgg agcagtagct gagtgcttac atcatgcctg aaagatgttg acagagtgag 69000
acagggcttt taaaaacaaa aaccacgttc cctgttatgc acctcctaca acagggccac 69060
acctcctaat ccttccccaa acagttccac caattagaga tcaagaattc aaacatgcaa 69120
atcatgctca ttcaaaccac cacagagcct acaaggctct cattcaaagc accacaagac 69180
agcaagacct atatgaatca gacctgaggt gatggctgta gcttcctgag aaagggtttg 69240
gggaatcttt ccaaggagcc agctttgctc tgtcccttac aagtagctgt ctccccagct 69300
ctctaggatc ttcctagaga ttagattagg atttctccca aacaaacaca aaaaaagtcc 69360
aaatggagag ggttcaaact caacatttaa aaaaagtgag tcacagtaat tatgttgggg 69420
ctcaaatatc tatttcttag gatagaaatc tctcatattt aaggtctttg ggaggagaaa 69480
catgaaaaat ttctggagtt gtcatgcata cacacataca catacacact atatatatat 69540
atgtgtgtgt gtgtatacac atatatacac acacatatat gtatatacac acatatgtct 69600
atatgtatat atacatacat atatacacac acatatatgt atatacacac atatgtctat 69660
atgtatatat acatacatat atacacacac atatatgtat atacacacat atctatatgt 69720
atatatacat atatacacat ataatattta aatatgtttt atatatttat atattataca 69780
taaatatgct taagtattat ctatttaaat atatatttaa tatttaaaac atatattata 69840
ccacacgcag tcctctaacc ctccattgga gatgtgcctg ttccgtgtta gttagcattc 69900
tcctactcag tcaccctctg cttcatccac tgcataatgt caaatgggag atctcacaga 69960
gaaagaacat gggacagcaa gttcattttc aagatcacat gacagttatt tccataagta 70020
tagacacgtg gatttcacat ctcgtttcgt ccatttgttt gaatgcagca tacctgtagg 70080
acggtgaaag gcagcctggt tcctggttga gctaaggcta gaaaccctac tgaccctaaa 70140
gggatgcttg gagtttgcct ggttcttagg taccaggctt catgcacgag gccacagccc 70200
tccatagatt tgtggccgtc agtaacgtaa gggcaacacc gcaagccaaa gccccccccc 70260
ccacctgcca cacacacaca ggtagaggac gtgacccatg gtcacctagc ctcaagacac 70320
atctctattt taatgaggta cctaaaggcc tggaggactt agccaataaa ctctccttcc 70380
cagatgttcc ttcctgcaaa aaaggtattt aacttcaggc cctccctgag aagtggggta 70440
cggttttact cagccacctt tcaccattac aataaatgcc ttaaaatcat ggattgctac 70500
ttttcaccgg gatctgctat ggagaagacc ttctttgcct acagagctac catctaattt 70560
cttgtagaag acctctctgc tctcccagcc atggctgcca ccaagctcaa gcttgctgcc 70620
acagacagcc agagctcctc ttttttcccc ctcagccctg ggctagattc agcccgctgg 70680
cccccactct gttctcaggt cttttgtggc tctcagtatg cctgggtgtc caagagcccg 70740
agaaccagac agctagggcc tccttgtagg ccgggggacc cccaagccag ttctggctgt 70800
cctgggatct cagactgtgc tttcccattc tggaagggtt attccatggc tccccataga 70860
ccaacaccag cccggtgaca gtgtggggta agctctgtca aaactccagc gttctgtctc 70920
cccaagtagc tgtgctctgt ggtgggcacc cctacacaca cccatccaca gaaacacaga 70980
tgagttcttc cacttagtct gagacatctg aacagctact aggttctggg ctaggggcta 71040
gacgtgggga gaatttgatg gagcgttgaa actgctgatg aggaaagaga agctctctgt 71100
tcacggctct gtcctggaca tccagagcaa agtatagaaa tgtacttatg ctataggctg 71160
aataactgag tgaatgcaag ctcctgactg caagaagttc ccaacatagc aagagacacg 71220
aagagagaca ttcttataac aatggtaagt gatgagaaat atggaaacag taattaatta 71280
tatccaagca taatggttac attccataga agcatttgaa gacccagaca ccaaatacaa 71340
ctcaaagaaa agtgatataa aattttctag tgtaagccta gtaatttcaa tgataagttg 71400
catcaaaagt caggaactga tcaatgcgat tctatcctct tcagagcttt gaccacgata 71460
agaaatagct tgatgccagc ttaacattag actctaaagc agtgaccttc ctagtgctgt 71520
gaccctttaa aacagttcct cgtgttaggc tgacccccag ccataaaatt acttcgctgc 71580
taattcataa ctgtagtttt gctactgtta taaatcataa ggtaaatatt gatatgcaac 71640
cctccagagg ggtcgtgacc cccacgggtt gagaaccagt gctctaaagt gaactgcagg 71700
tgtgctgtgg gctctaccac ataaacaagg atgccatagc ttttctactg ttgttgttcc 71760
ccgtttccag gcttatcatt aaccatcatc aggagatacg aggcccaggc atgtgacagc 71820
ttagcagaag acaggccaag tgcaaccttg tgtggagctc attctctgag caaatgttca 71880
aaggctctgg gggtgctcat tgctcagtct cactttgaag cctgtactat aggaacaggc 71940
attatttcca ctctgttgat aaggaatctg agacatgcat tgtgatggcc ccagtattat 72000
acagctagca aagggtggag ggagccagga aggacatttg tagagctgag tgactcaagg 72060
tcataaaatg gcaagtggca agtggcaagt gaggtgactt gactcatacc tgcctggaac 72120
cttttgtctt gactcaacca aactcctcct tattgatttt ttaaaaaagg tatcttttta 72180
aaaaatgtat gtgcatgttg cactggctgg ttctgtgtgg cttgagttat catagagaaa 72240
gatgcctccc ttgaagaaat gcctccatga gatccagctg taaggcattt tctcaattag 72300
tgattaaggg tgggagggcc cactgtgggt ggtgccatcc ctgggctggt agtcctggat 72360
tctattagaa agaaaggcag gggagcaagc cagtaagcag cacccttcca tggcatcagc 72420
tcctgcttcc tgacctgctt gagttccagt cctgacttct tttgctgatg aacagtaatg 72480
tggacatgga agctgaataa accctttcct ccccaacttg cttgttggtc ctgatgtttg 72540
tgcaggaata gaaaccctga ctaagacaaa cgtgtctgta cccgcatgtg tttatgctta 72600
ccatgtgctt gcaggagccc atagagaaca gaagagagct tctcaagcga tcctcggaaa 72660
ctatgagctg tctgtgggtg ctgaaaactg aacccccatc ttccataaga gcaataagca 72720
ttcttaacta ccagacaatg cctccagccc tttctttttt ttttttatta cgtattttcc 72780
tcaattacat ttccaatgct atcccaaaag tcccccattc ccctacccac ccatttccac 72840
tttttggccc tggcgttccc ctgtactggg gcatataaag tttgcgtgtc caatgggcct 72900
ctctttccag tgatggccga ctaggacatc ttttgataca tatgcagcta gagtcaagaa 72960
ctccggggta ctggttagtc cataatgttg ttgcacctac agggttgcag atctctttag 73020
ctccttggat actttctcta gctcctccat tgggggccct gtgatccatc caatagctga 73080
ctgtgagcat ccacttatgt gtttgctagg ccccggcata gtctcacaag agacagctat 73140
aacagggtcc tttccgcaaa cgcttgctag tgtatgcaat ggtgtcatcg tttggaggct 73200
aattatggga tggatccctg gatatggcag tctctagatg gccgatcctt ttgtcttagc 73260
tccaaacttt gtctctgtaa ctccttccat gggtgattgt ttccaattct aagaagggac 73320
aaagtgtcca cactttggtc tttgttcttc ttcagtttca tgtgttttgc aaattgtatc 73380
ttatatctca ggtatactaa gtttctgggc taatatccac ttatcagtga gtacatatca 73440
tttgagttct tttgtgattg tgttacctca ctcaggatga tgccctccag gtccaaccat 73500
ttgcctagga atttcataaa ttcattcctt ttaatagctg agtagtactc cattgtgtaa 73560
atgtaccaca ttttttgtat ccattcctct gttgagggac atctgggttc tttccagcct 73620
ccagcccttt cttaatcact ggactatctc tccaatcctt ccttattgac atatgtttaa 73680
aatgtaaagt atttttgtta tgtgtgtatg caaatgaatg tgctacaaaa aggatgtgga 73740
caacattgaa gaattggttc tttacccacc caaggatcaa tcccaggctg tcattgactg 73800
ggcttgctgg ccacttagta aaaaaaaata ttacatttgg taggaaggct ggctatcctc 73860
ggtctaatga acttcctgac ccaaccatcc cagtgatata ttatagacat acatcaccat 73920
gtctgacatt gatagttgga ttattttttt taattttgaa ataagttata acacattaag 73980
tttaacaata ctataacgtt cacattttct tttccaccag tttcccccaa gtaagttagc 74040
cttagacata atcaaaacca ggagattgac attattatat taccaagcaa agacggatgc 74100
taggtggttc acgctggttt cttgcacaca cttttctgat gtattttaaa catcagatgt 74160
actgattcct gtacccacca ctaccatctg gaaatagcac tacgaaatgt ccctaaggac 74220
actcttgttc acaattgtac cttccctttc accaccagac atggcaactc ttccacacag 74280
ttgtcactta cagagtctta catcaatgaa atctggggtg aatgtgccat ccaaagaaac 74340
acaggaacca gagttgggtt ccaggaaccc atgagaaaaa gcttgggtag tagcatacac 74400
tggtagttcc agccctggga agacagaaac ggtgaaccac tgagatttgt agcaagccaa 74460
cgctaccttt tctcacattt agccctactt ggtgagccca ggccaatgag agaatctgtc 74520
tcaagaagca aggtgcgcga catgtgagga agaatactca aggtctcctc tggtctccac 74580
atacacacat gtacatactt atgtacaccc acacataaat ttgctcctcc ctttggacac 74640
atgtccagga gtgtttagaa actggatcac ataccatgta acctccagag actggctttt 74700
ttctcattga tgtgaatgta gcatagttta ggcatcctca cgctgaaggg cttttggatc 74760
atttttaatt gaagctattt acaaataaca ctgcaatgac cacttaagaa cagtatcgac 74820
atggattttt atttctttga caaatatcca ggagcaggat cgctgggagt attagttact 74880
tttataacac accgcaacaa aatcagcttt tgggagggtt tatatggggc ttataaagga 74940
atgagtccag caccatcatg gtggggaagc atgtctggag gcaggaatgg tggctaaaca 75000
gcagctgaga gctcatgtct tgaacaataa acaagaagca gagaggctaa atttgaaatg 75060
gcacaaatct tgaggtctta aagcccatcc ctagtgatgt attcctccag caaggtcaca 75120
cctactaagc ctccccatac acccatcagt tagggaccaa gtatttaact gcccagacca 75180
tgggggatat ctcattcaaa ccactacact ggataaaggt aagcttaatt taaatgagaa 75240
atgcccccga caggctcagg cattgcacac ttggtctcca attgtgggca ctatttgggg 75300
aggtttggga ggtatggtcg gtcctgccat aggaagtatg tcactggggg agggcttcga 75360
gaatatataa ccccgctcca cttaccattt gctccctctc tactgcttgt ttgtggttgg 75420
agatgcagtc agtctcttgg ttccctgctc ctgccaccat gcctgtccct tgcagacgga 75480
ctcttctcct tccagaccca aaagctaaaa ataaactctt aattccataa gttgttcttg 75540
tcatgatatt ttgtcacaac aacaggacaa ttacacccct ctctccccaa ggttatataa 75600
atagtaagga cctctgtgga gacaggatta tttccagtct gttgtgttgt ctgcaaatca 75660
tgtagagagc tcttgggata cacccttcat gagtcatcac ctatactcag ggtttttgag 75720
taatgcagta ttgtacttgt attgtccagt gttcctgtca gtaagttctc acccataatt 75780
ctgtaagtaa tccagataaa cacattggct tttgaatgga cactttggta ggatagtttc 75840
tttagtctgt cattggtgct ttatctgggc tgagtagatg tttgcatgaa gtctacactc 75900
tttgtttttt gtttgtttgt ttgtttgttt caagacaagg tttctatgta tagccctggc 75960
tgttctggaa ctcactttat agaccaggct ggcctcgaac tcagaaatcc acttgcctct 76020
gcctcccgag tgttgggatt aaaggtgtac gaacaccacg cctggctgaa gtctacactc 76080
ttataaaaaa aatagtcctg ttctcacttc atttctgttg ctgtgataaa acaccttggc 76140
caaacagaac ttggggaagg gaaggggttc attatggctt acagttccag gttctggaca 76200
gtcgatgaga aggcaagctt agtcacctca cacgcatagt aaaggacaga gaaaaatgaa 76260
tggatgcctg ctgcctgctg cctgcttgct gactgcctgc ttctgtttat cccctgccat 76320
aaaatagttg agaaccttct gcatagagaa tgttgctgcc cacactgggc tgggtcctcc 76380
tacatcaatc aacaatcaag acagtctccc acagacatac tcacaggatc taggcaattt 76440
ctcaaccgag actctcttct caggtgattc tgggttgtga caagttgaca gttaaggcta 76500
accatcacag tgtatattag aacttatttg ttctaataaa cttagtaatt cccatgggtc 76560
attagctcta cctggtagga actatctttg tacactttgt taatacaaat tgactacttg 76620
ttttaatacc tcatataaaa tgacagctgt ggcatttgtc tttctatgat agagttattt 76680
cacttagcat gtctttaaag tttatctgtg ttctcatgta ttacagaaat attcataatg 76740
ttaaggctga ataattttca tgtgcatgtg tacagacaca tgcacatact ttctttgctc 76800
atttgttatg agggatcata caggttgttt ccttaagttg gctactgtga atagagctac 76860
catgaagatg gggtgaaaat atctgtttgt gatatttaga atggctcttt tgggtaaaat 76920
tcttttgaat actagatcat gtaagagtcc aatttttaat tttgaaaaaa tatttatttt 76980
tattttgtgt gtatgggtgc tttgctagca tgcatgtata ccacacgtgt acagtaccta 77040
cctgcagagg tcagaagagg gtgttagatc ccctagaact ggtgttacag gctgttacga 77100
gctgctttat ggtgctggca accaaacgta ggtcctctag aagttcagac agtgctctta 77160
gccactgagc catcatcttc tggatgtatt tttgagaacc tactatactc ttctgacatg 77220
gcatatcatt ttacattctg tcagttgttc aaaaagcttg gagtttcccc atatactcat 77280
taatactggt ttatcaccat catcatcatc atcaacaaca acaacaacaa caactttatt 77340
ttataatggt aattgtgaca gatgtaaagc aatatttcat gttggttttg atttgcatct 77400
ttcagatgtc agtgactata tcctcgtggg tcactcatat gacttcactg tagaaatact 77460
ttaattattt aaccccctat tcctcccctc tccacttttt atagtaatga gggttgaacc 77520
cagggcctca tacatgccag gcaagaacat tacccctgag ttgtatcagt cagccctact 77580
caatttttca gcctctttta acatcaagat agtaaatgtg ttgctgtttg gaaagtttgg 77640
ggattttatt acatcttggg agttccttat atactttgat aattaacccc ttagtggctg 77700
gatggtttgt aatattttta tcctttttcc tgagttgtct cttttttctg ttaatgtttt 77760
ctttccttat gtgatgctat attggtctga atgagaagtg ttccctgcag gcctgagcat 77820
ttgaatgctt ggttcctgtc ttagtcaggg tttctattcc tgcacaaaca ccaagaagca 77880
agttggggag gaaagggttt attcagctta cacttccaca ctgctgttca ccaaaggaag 77940
tcaggactgg aattcaagca ggtcaggaag caggagctta tgcagaggcc atggaggcat 78000
gttacttact ggcttgcttc tcctggcttg ctcagcctgc tctcttatag aacccaagac 78060
taccagccca gagatggttc cacccacaag gggcttttcc gccttgatca ctaattgaga 78120
aaatgcccca cagctggatc tcatggaggc acttccccga ttgaagctcc tttctctgtg 78180
ataactccag cctgtgtcaa gttgacacac aaaaccagcc agtacagttc ccagttggtg 78240
gtgttttggg gggaggtttg gataccacaa gcttgttgga gaaaatgtat cactgggagt 78300
aaactctgag aacagatagt ttcccacatg tctagttcat acctgctgct ttgtgcctgt 78360
ggtccgagac atggctctca gatctctgct cctttcacca tgcccgattg ctgccgtacc 78420
tcacaccatc atggacactt atccctctgg aaatcatgag gcaaataaaa tcttcttcct 78480
ataaatcgcc ttgtactcgg tattttatca cagcaataga aacggaacta tgtagatggg 78540
gtccctgttg tctacttttg cgtctgttgc ctgtgcattt ggtgatgtat ctatgaaatc 78600
gtagccaaga ataaaggcaa agctctttcc ccatctgttt tcttctgaag ttttatcatc 78660
tggggcatat ctttaagtct ctaattcatt tagagtttgc ttctgggcat aactcttttt 78720
ctcaatatgg cagtgttggg gactgaaccc acagtcttgt gcatccctgg tgagtactac 78780
ttcatttaat gtttagagaa gccccgacta ttccctaacc tgactctcct tctcagtcaa 78840
gtttttattg atggacgcag ctccagtttg tatcagagaa tgaaggttag cacagtatct 78900
gttttcatgg aacttctggt aaaatataca tccataggcc aatatacatg aaaaacaact 78960
acacccctga ctgccttcac caacctattg ctggtatttt atttgtgata gttggaggta 79020
gggtgtgtgc ctgccactgc atatgcgtag aggccaaagg acagctttgt gagtagttct 79080
ctcttacctt tcttagcttc taggaagtga gctaaggtct gagggcttgt gtacaagtat 79140
tttatttgct gacgcacctc accacccttc attaccaaca tttcaatgtt ccccagctgt 79200
atattaaagg gcccaagaag tctataatgc agtaacctgc ttaacatcac tgacacagaa 79260
cttattaaat ttgcatgaca atgtaaaaca tacggattag tatataattt aatttaaaga 79320
aatcttaatt tgcttgcttt tataaatgca atttgttaaa ttgcctcatg gaacagctat 79380
tttcttcaga ggcaaataaa agagacacta atattggtaa tcctgcttca cccaggaaga 79440
gcactggtcc tagtcaggag tccagcaccg ccgtcactgt tgggtatgtc tttacattta 79500
agtcaagttc agagttcaga gtaagagact atcccagatg ctagggtggc tttgagggtt 79560
ctgagaaccc aaaggtcacg tgaaagatat ggttactatt gtcaggctga ttctaatcag 79620
aaatcagagt ctggagatgg agcagatacc attgagaagc agttaggagg tggtaatgtg 79680
gcactgacaa cccagccaag gctcaggtag cggtggacat gcgcatttgc tttctcttgt 79740
gtttatcggg caacaagcct gggtgaactg gaaagcggat gcggtctgaa ggtctgcatg 79800
aaaccacaga tgtcgatccg tggggggcag actccggggg catgtgtctc aggggtatag 79860
cacttggagg tggcaaggac taatttcaag gtctcacact ttaaaagcct aaagtccaag 79920
cataggtggg agcccagcct agactcagag cgcagacgcg gacagagagc atgctaggag 79980
cctctgttgg acagtcaaac atgaccgagt aagaccgaaa ctccatagag acagactgag 80040
ggaagggaga ggttaaagac agggaacctg ggctctaaga tctccctgta acagctctcc 80100
ctttgtaaga ttggatcgaa tccctagggt aaggggcaca gctgagcttc caggtgagac 80160
aagagtaggg agaagaacca tcaggtaaga caatatagtt agagccccaa accaatgaac 80220
caactaacca accaaccaac caaacaaaca aataacccaa agaccaaaaa aaaaccccta 80280
aaaatcaaaa cccaaaccaa aaaacctcaa aacacaaaac aaaacaaaaa gacccatgag 80340
ccacaggagg aacacagttc tgtgaaccct gggctcaaac aagggtatgg atagaaatta 80400
aatgttatat ggatggaagg ggacctggag aaatcccagt gttttctctt ggatgaagac 80460
tcttgatccc tgaaactaag tctcacaagc ccagatgaag ttgtgagttt aaatcttgtc 80520
aagtgtgaaa ctagagccaa cagtcaaatg cctccctcca ccagctaaac cagtccattt 80580
taacctgtgg attaaattgt ggtttaattt taggccagaa aaaaattttt acttgccata 80640
aatttaagtg ctttagatac ccatgacata aagactggag cattatgtaa aagggaggca 80700
cattagaggt catttaatga cttgtgccac ttcagagctt tctatcacat agtccacagc 80760
aattcaaagt catgacccct agaactaaaa acattaccca tcagcctttg aactctgaaa 80820
ccggccaagt gtaataagcc cagagcaaag tacagacttt ccagtgactg agcacaggca 80880
gtgactagac cagatcggcc atagtgagac cacacactgg ccctactcag cgggcattca 80940
ctcagcctag attccatttt ggttgctgct cacctagtct caaaaagtct cagctaagtg 81000
atgtgacagc cctttgtgct aggacatgat ctgttctaaa tatctttcca caggtgtgct 81060
gcaaatcacc gtcaacctga taagaacaat ccctacaata aagtgagtta tttataccaa 81120
catcctccca tgttgttgaa ccaatgaagc aaatgtggaa gaataatgtt tggctccttt 81180
ctgttttgaa aacattttct gggaaagcag gtgtttgcag actaaataga tatgcatgcc 81240
atgggtgata gatagtctta gatgtcaggt cagttcttca tcggggacag atctttggag 81300
gacactgtaa tattggtcat gacagaatag attctgatag aagttggtgt ctaaaatgaa 81360
aatggcttgg agaccacagg tgatcgggga gttcctcatg gctgttactt ataggaagaa 81420
ttcttccctc ctataagccc tgctccatcc agctcccaaa gatcaaccag tattaagact 81480
gacgttgttt aaagcaccac tatctgtccc tgtatctact ccaacgcatt gagccagcta 81540
tatagcactt tttttccgtt ccccaataac cctaaatttc ttctacttct tgttggagat 81600
gtttcctttg ccccagatgt ctttcatcca tccactaagt acttccatcc cttcctgtac 81660
tagctaattc tttcctcccc tccaagactc atcacaccac cgtgccctcc aggatggctt 81720
ctctcagtcc tcactcatgg actgagaggt gctcccacct cacttgcctg gtaggtgctc 81780
ccacctcacc tctgcatgcc aggagctaag aaaaggaagt tagaacatta ctagagattc 81840
gcttggaagg aaggcaggaa ctgagatgga aagatggggg gggggggaat gataaaccat 81900
atggagccac atgaaacctg gggttgtgtg cagtaagggg tgaaaaggga tctggctaac 81960
tgggtgttct caacgcaagg aaagttcata agacaaaccc aaatgagacc attaatactg 82020
ccaggtacag ggcaatgtct acaacaacga cgatacagaa taacccgtgg cctggagagg 82080
tggctgggta catagagtgt ttgctaagca aacaggagga ctggaaacca gaactttagg 82140
atcatataca ttccagatga gcctggcagc ccaccaataa taccaatact aattaggcag 82200
aggcaagggg agctccaggg caaggtggct tgctgaacta gcaaaatcag cgtgctccag 82260
attcagctgg aaaccctgtt tcagtgaata agatggaggc aataagacat ccagtgccaa 82320
tctctctttc ccacatccac atttgcttgg tcacacagga gtatccacat ccatccacat 82380
gcatgcatac acagccccac acgcatacac atgtgggaga aaaggaaaaa ggaaagaata 82440
aagtaggtag acatgacgtc gagaagcaat ttaagcaggg tggatgtgtt ttctgtccat 82500
cccttgtgtg tttgtttctc tttcctaagc tccactgttc attaggggaa agttcaactc 82560
acataaactt ttcatgtctt cttcagatat cctcaccttg agatgatgta gtgagtaggg 82620
tcttgtgcac aaatccctca gggtttggag tggggtatgg gtgtcaaagg gcacaggtga 82680
aacaaacctg gctgtgcact gattcttgta gggtctaggg ttttatgggg tgcttctact 82740
tttgggggga cttgacaatt attcacaaca aaactacaaa acagcgcatc aggaactatg 82800
ggttcttctc aagtggaggg cattacatat taactgaatg cgtacacatg cctttaagat 82860
gggatatgca tatgcactgt ctaagatacc ccgagaaggc actgggtatt tcagatgctg 82920
aacacagatt ttcctaagct cttgccttca ggccaaattc tgcttttcct ggactatggc 82980
actgtgcaga gaaaaattat ttgagggcaa ggtggtgaga agtcttaaag gccccatagc 83040
cgaggatggg gtagggctgt ctcttctcct gtgatcactg aaggcctctt atattcaaca 83100
gacaccaaat ctgagaggtc ctaccatggc caaggccata tcccctttct tatgttcaga 83160
gatggaaaag gaggataatc aaagtgctta actcacaggg tcattagtac catgaatgtg 83220
ttaaggttta gtccagtgag ttgttagcat cgggcatctg tgctttacta tcagagttag 83280
tgtttgcgtt ggagttagtg ttatgggtca atagttacca gttagtcaga cacacactat 83340
gatggatagg ttgtttatag acagagagaa gacatggttt tctgaatata agacggggaa 83400
ggagtaccag ggctaggaat gagcagagaa actatttgag gatgcagctg tgtataattt 83460
aggcagggtg tgtaggggag gggagagatg tgaaccagga agcaaggcag ggctggatgg 83520
atgatggtgg gcctggcatg gggcagcaaa gttgagactt gaagcaggag gccccgagga 83580
gccagggagt gacctggtcc agggaggggc gagatgaaaa catacttcag gaggattagg 83640
ctggcatgag atataaagtg tctcggtttt gggcaggttc agaccaaggg tcgagaagtc 83700
cctacagagc tggaaatttc tagacttcct ccagcctcag gctccaagct acatttttgc 83760
caggctgagt gggaatcctg gagttttcca tgggacccaa caattcatct ttgtgtcttc 83820
tgttaccctc agctttgttt ttgtgttgcg taacatttcc aggtctcaat atcccaagca 83880
agctggagtt ttcagaggtt aaactctaga acctacccag cctgggtggc atctctggaa 83940
gcaaaaagag acacccccct tttgaccaga gatccttgta gacaaatggc cttagctgac 84000
cctggctgtt ctttggttca tataacaata ctcctctcct ctctctagtc cttctcccaa 84060
cctgtttaga cacaagactt acataaacct tctccactcc cctctgcttc ttcaggtgga 84120
accttgaaga aaaaaaaagt tgttactagg ccaaggagca aggtttggaa agacacgatg 84180
tgctgccaaa tccaggaaag caagttaatg agaaggtgag actctgtcca cccactttct 84240
ttcattggcg gaatttttag gtaacaaaca tagctccagg caggtgtctg tgccccactc 84300
ccatgctgag caggagctgg acccgagctg caggtcccac tcagccattc agtggcttca 84360
tctctgcacc atctccagac ccctatgtcc aattgcacag cagtgatcca ggtccttccc 84420
tctcgaagtc cttttgagct ctagctttcc aggatgccct tctacgggtc agtgtgttgg 84480
tctggatgag tcctgggtct gaccagaact actctgaaag ggaagataaa gaaagagcct 84540
tagaagaact agctgtccta acaacaggag accccgtact cacatactaa tgtgcactca 84600
tgagctcatg tggaagtata catataagca acactggtga gcacatgcac acacacacac 84660
acacacacac acacacacac acacacacac acacagcatg catgcatgca cgtaaaataa 84720
agcttataaa acaaaacaaa acaacaccaa gaagcaagca agcaagcaag acctagggtt 84780
tttatacatc tgttgtggga ttgttgttgt tggtcttatt gtgttttgca tttttggttt 84840
gagacaggtt ctcactatgg aaccctggct gacctgggga ctgcctgcct atgcctccca 84900
gagtgctggg atcaaaggtg tgtgccaccc atgcccagct gctgtggatt ttataggtcg 84960
ttgatggctg ggttttggtt atgagtttaa cactgctgtt gaatgcagag agccttttaa 85020
atcgagcatc aatgaggggt tgttttgtta ctgaggggct ggacatgggt ttgcttagga 85080
ctgagatttg ctttctgttg cctcccttgt tctgagcgca attgcttagc tagatgtcga 85140
tggcctttca ccatgggttt cctgtgagcg ttacaagctg agattggcag gtgcattgag 85200
gaggtgggca aggggagggg cgacagcaca atgctgtttc cctattggtg ctaagtgctg 85260
ttcctgttta ataagtgcag ttttgaactg gaagagagga ggtgtgaaaa caccacacga 85320
gtcccctaaa atagcctctt aacaaccaaa tcaggagtag aatctggtct ccgttcagga 85380
aacagggtgc ttggatgtcc actcccctgg ggctccttag cccgtctttc cccttaggtt 85440
caaaggttct tcataacctt tgggtccatt gactttactt ctgataatat caatgacctg 85500
gggacatcca ccttacatat gaaggacccc tgtcggcatg agtagttgtc tattaactgt 85560
caccatgtag tcagcttctc tggcagagat gattacaatc taagtctaga atgctgggac 85620
cctttaatac agtttctcat attgtggtga cccctaatct tttttttttt tttccgagac 85680
agggtttctc tgtatagccc tggctgtcct ggaactcact ttgtagacca ggctggcctc 85740
gaactcagaa atctgcctgc ctctgcctct ttgttgttac ttcatacctg taattgtgct 85800
actgttatga atcataatgt aaatatgtgt gtttttgata gtcttagccc ctatgaaagg 85860
gttccttgaa ccccccaaag gggtcgtgcc ccacaggttg agaaccagtt ctctaaagag 85920
ccatttatga ccccctcttt ggctatcagg cttctaaaag aatttcccta ggaatctcca 85980
catgggagaa gaaatagcca aaaccccagg gacatccaga ggaagaccta atgttttgtg 86040
aagaattttg caacttatta gatgacttca tagagagttg gcgctgagac ggccgtgggc 86100
agaggccaca ccttgtctga actattcaac tatgcatatc ttttcttttt ttatgtaccc 86160
tcacgtatgg aatttgaaat caaacttgga tgtagtggtc actgtatttc ctttgtccct 86220
ctttccattg tggccacttt gaataaatct ccattttaat ttggctcttt tatttggctt 86280
gttcaggata ggtggccaaa cctggctagt tgggggctca ggttgaaacc ctaatctggt 86340
aatagtaaca tatgtcctga gtctggacct gtacagccat gctcagtaat gaagaacaag 86400
cagcatattg gatctctcct aaggggtgaa tttcacccct gctaaataag caataattga 86460
tcaaacaagg actggctgca tgctttttat gctcctcagt attcgggggc agcctcctct 86520
ttttcactac tccaaattct cattctgact tgagcttaga gttgtgttta ctccagactc 86580
acgcggtttc ccttgattat tattgtgtgc ctctccctct gaagctgaag aaatagctga 86640
tccttacgtg cttgtggagt aagcaaagaa gtcacatgac tggatcagta caaaaatgta 86700
ttccgctttg ctgtagtcca gtgaatttga agccatggat attttccctt ttaaatgtac 86760
agttcatgtt tagagaaagg aacgcaacga tgtatcaatt gcttgtatac ttactgtcaa 86820
agtagcagaa gttaacattt aggctcagta cttttgaatt tccttctttc ttgaagaaat 86880
ggagcattac attcatttcc atctctactg agaaaaccag ggctgagtgg ccagccatgt 86940
gcttgctgtc taaaatgcac tgatggggac tggagagatg gctccatggt aaagtgtttg 87000
ttctgcaagt atgagatctt ctgtctagac atccagaaca acatctaaaa atatctagat 87060
gtgatggtgc cttcctgtaa ccccagcagg ggtaggaagg gaacaagtgg atccttgggg 87120
ctgtctgatc agccatttca aagaatcagt gagatccatc atgaatgaga gaacctgcct 87180
caggaagtaa agggagaggc tggagcaata gctcatggtt aaaagcactg gctggttcca 87240
gctctagcag caatctacac ggtggttcac aagcctctgt aaccctagac ctaggatgta 87300
atgtgccctt ccagtctcca aggatactgc atgcatgcat ggtgcacaga cacacatgca 87360
agcaaatacc caggcacaaa ttaataataa tgatgatgat gatgatgatg tagatagata 87420
gatgatagat gatagatatg tgataaatag ataatataga tgacagagat aaatagataa 87480
taggtgatag atagatacct agatggatag atagagataa tatagttaga tagatatagc 87540
tagatatagt atagatagat aaatagatag agatagataa atagatagag atagataaat 87600
agatatagta ttgttcaata gagatagata atagatagat agatagatag atagatagat 87660
agatagaata gtatagtata gtatagtata gtatagtata gtatagtata gtatagtata 87720
gctagctagc tagatatgag tgtggtagca catctgggag gcagaaaagg tctgcaagtt 87780
tgaaggcagc ctggattaca aagcaaattc caaggctaca tagtgagaca ttatctttta 87840
aaagtacata tataaagtaa agcagaagca gaaataagga aggcactgcc cgttggcttt 87900
tgtccacata cacgtacaca ctcttactca catgtgcaca catataacca gggccataca 87960
gaatacacac acacaaagtc taagaatcta gggccaacga gatgtctcac tgggtaaggg 88020
cacttgctgc tgagcttgat gacctgaggt taagccttga gaccagctct cacagatttt 88080
cctctcatct ctacgtgcat gcaagtgtgt gtgcgcgcac gcaggagtgt gcatgagacc 88140
agtagagggg tctttttgtc cattgtcatc actgtcttca aatcagccat atcaggcact 88200
tggaacttgt ccctttcata tacttcctta gaaatccctc cgttcaatgt cacttttctc 88260
atttggactg gttaaacaat tccctggact gttctctaga aagacagatg tgtgaataat 88320
taactcaacc tcattaatca gttgctaccc cggtttctaa gcttcaaagc tgagttactt 88380
gcccttagag catagaattg gtttataaat ggtgtatgca ttcatgtatg ctaaaggaaa 88440
ttatacgttt tatagaactg agaatatgta aagtatataa aatgtactgt gaaaaaaatt 88500
aagaagatag agacgacttt ttaagcaaat tcaaagagct taaagtctta ttgtagatag 88560
tgttttaaat ttttttcact tataattatt gtgtttgtgt gtgactgtgt gtgtgtgcat 88620
gtgtgtatct gttcatgtgc atgttccaca gtgtgcatat ggaggtcaga gggcaaactt 88680
tcagagttca cgttccactg tgtactcaga ggctcaaatt caggtagtca ggcgtgcaca 88740
gcaagcatct ttctacaccg agggatcttg caagcccaag tgacatcata tcgatactct 88800
taaaagtcat tgccttcaag ggcaaaggtg atgtcataaa aaagctcgtg cttaagtcag 88860
cttaagtcag agagcagcct gcagagttct gtgctgctga caccgtgctc attgcactaa 88920
gcctggaact atgggaagct cacagataac caatacacag acagttccct gaagactgta 88980
gtcaaggaga cgggtgcaca cagctaaaca gaccacaagc cagcgaagca gatgctgtga 89040
cagtcactta aaggacatgc tgtgggtgag actagggagc tgggagtagg tgccaataca 89100
gcaaaattcc ttgtgcttac caaatggtcc atcctcactg tcagatggca ggggcatgca 89160
ggacacagtg gtggtctttg acttggttat gaaggatgaa aagacttcaa caggaagaca 89220
aattggggat gaagatgtag gcagtggagg gaaaggagaa gcagtctaac tggggctgaa 89280
gagataacca gaggacacag tgttggatat tttcactgag attaatcaac agttcagtct 89340
ttggtccatc agcccctcct ccacacacac atcccccact cgtttttttg aggtatggtt 89400
cacgtgttcc aggctagcct caaactcacc aagtggttag ctgaagatga ccttgaactt 89460
tagactctcc tgcctgtact tccccagggc tgggatgaca agtgtgcact gccctgcctc 89520
aggtgtgcac tgccacgcct ggcttgtgct gttactagag atggaaccca aggcttctgg 89580
tgttctgggc aagcacagcc tggctcacat ccccagccct ggtccactct tgtctctttc 89640
cacagtgatc tatctagtct tggtcccagc accttgctca gagggagtgg tcaccgatga 89700
cctctccgct gtttacctgg atggaccctc cttagtccct cattccttgg cctcttgctg 89760
atgtcacttg tcacgtcaac cttgatgtcg atggccacac tgacatttgg gtcccttgtg 89820
gtcttcatct gtaacatcct gtccaccgct gtattctctt tgttttgttt tgttttgttt 89880
tgtattttcg agacagggtt tctctgtgta gccctgcctg tcctggaact cactctgtag 89940
accaggctgg cctcgaactc agaaatccgc ctgcctctgc ctcccaagtg ctgggattaa 90000
agacgtgcgc caccactcac ggcaatattc tcttttatct atgttcagat gccttttctc 90060
tgtcagttct tcctcatctt acatctttat gagcatgtct cctgcagtct taaggacatg 90120
ccctctccta caccatgcct gaattgttca tatctaactt tcaggtctca tcttaattat 90180
tactcacctt aggaacagtt tccccaaact ttgcatctgt ccagtaatga gcctagagat 90240
aaaactttat cagagataaa tgcctgagta cccagctgtc ttcctagatt agcccatgcc 90300
attctttagt ttcttttttt gcataacccg attataaatg taaaagtcat gtttaccata 90360
atattcccag cacttaacac aggctaatca atatcaagtt cttaataaat attcaatgag 90420
taaatatgtt attcaggcaa catcaagaat gctgggttga ataagtaggg ttatatagga 90480
agaaacaaga gaagaaatag gctggatgaa gaactttagc tttccacttc aaacatttaa 90540
ggctattcta cagataaaac tgctatttaa agttgtggtc cagtcttcct ctagtaacat 90600
gctttgttag ctggtgtagt gtaaccaatt agccagttta gtcaagggtt agcagggtag 90660
actacaccac aactgtaaga gcagcaagac agaaggactg aacagggatg gtgcccaaga 90720
gaatgctggg agttgatagc gaggcaaggc cccattcggc atccttttct gccctgttat 90780
cattcactag gagaaaagag tgcctaagga aagccagact tagaaggaag agaggcagag 90840
agctcatttc ctgatgcaga atcagccggc aggatattag tctatagctc aggggctccc 90900
tgagcaggag ctgtggattt gagagatatt tgggaagaac tattagatga agatgtgagg 90960
gttgtcaagg aaagcagaca aagggaagcg agtcaagagc taggcatgtg tatgaactca 91020
aatagcaaca acaacaacaa cagcaacaaa tgccatgtat acatggaaga gctcgtggcc 91080
gaaatgacaa aggaaacaaa tgttttaaac taaattaaag aaatgatcac gtttagatat 91140
tgtgcttaaa atcttcagga ggtgaaaggt gatctggaag ctgacaccga gcaggggcaa 91200
aaagagagca tgtcacagtt aggtttagtg ggtagaaggt aacatgggga tgatcagaga 91260
accactgaag tgggggaggg gtggtgatat ctttgttctt cagacacaga agagcagaaa 91320
caaggactca ggcatgcgtc gtgacagggt tagaggcttg gttaggtaga aagttaggtt 91380
tccatgtgtc cggggagcgg ggaggagaag aatgtgttca gggcaaagat ccaatgtata 91440
aacttttatg gccaacagaa tgagggctct cagctacaga ggaaacactt aatccgcctg 91500
taaatttcag tccgtcatac taacctgaca tggcagctgg cgtcatcggg acatgagcaa 91560
tggttccaag cagagttgat tgtgcttcct cactctaatt attaaccagt cactgtgtta 91620
gctcattcac gttgagaagc ctcccgcctc actacccatc tgtatggaga cttcttttct 91680
acgaaagaag tatgctcatt ccaaataaca tcaagtgtcc aaatcattag tttttactct 91740
ttgttttcat atgctatggg ttaagtgcag agctattaaa atacaaaaaa aaaaaaaaaa 91800
aaaatctgga atgagccctg acaactgact tgattccaat cttatctgcc attttctggc 91860
tacatcattg ggagacttac ttaacctctc ttaggtcaaa ctacattatt ggatgtttca 91920
gcccattcta attttttttc ttttctcagc cttttcaatg tgtatttact acttgaacgt 91980
ttttcattta aaaaacaaac aaaaaaaatt gaaaaaactc ccagaacatc tgctatgtgt 92040
cagctactga aggaacacaa tgtttaagac ctaggttcct ctcatgagtc ctaagcttgc 92100
tttagtaggc agtgacagaa ggacaaactg gtccatccat ctagataaac ttcggaaagt 92160
gaccgtgtcc atgggaagtc ctccttagac actgtgaccc ttgagttcag cctcagagaa 92220
tggatccaag ttaattgtag gtgtggaagg ttgtgttttg acacagggga caggcaagtg 92280
acaagaaggc actgagttca agggcacagt atattctaag tgtcagttgc cagtggctga 92340
acatagagga gggaaagagg ttagagaagc caagttcaaa gctcagacta tgcatacagt 92400
ataaggttaa ggcactgatc ctatagctat gttacctatg aatgagtggt cgttcttggg 92460
caagggacat aactcaatag gtttttcgct tttccagctg taaagtggaa ttgaaaatgg 92520
tatggcatag cgacctcaca tagaagtatt caaaacaatg tctagggcac ggttatggtt 92580
atggaagcct cttgaagggc tccagcaagt agagatttga gttgcaggca gaggcaagcg 92640
aagagtggat tggagagccg tggaaacggg agtggaaaga tgttagaaaa aaaatacagc 92700
ctgcactcag gagagggtat ggagatacag gtgaagcaga cggctggtgt cagtcttgac 92760
agcccatcag gtgaagatag gatgagcggt aactaatacc cagagttcta cttcgaacac 92820
atagttttct gtttgtaccc taactacatg cacgcgcgcg cacgcatgcg cgcacgcgca 92880
cacacacaca cacacacaca cacacacaca gatacataca cagacagaca gacacacata 92940
aacagacaca cacacacaca cacacacaga gagagagaga gagagagaga gagagagaaa 93000
tgactatatc ataggctttg gggcagggac aggtgggcct aggtacagag tcctaacttt 93060
tatcttgctt tctctctttc tttctttctt tctttcttcc tttctttctc tctctctctc 93120
tctctctctc ccttccttcc ttccttcctt cctccttcct cccttccttt cttctttctt 93180
tctttcttct ttttcttttt tcttttttct ttttttttct tttctttttg ttttttcgtt 93240
tttttggttt ttttgagaca gggtttctct gtgtagccct ggctgtcctg gaactcactc 93300
tgtagaccag gctggcctta aactcagaaa tccgcctgcc tctgcctccc aagtgttggg 93360
attaaagacg tgcgccacca ctgcctggtc tacttttatt gattttttga tattttcctt 93420
ccctcacaaa gaagttgaca aacagcctgg cagagctgtg agaactgaat ggagactgag 93480
taggaaccgt gccctggatg gtgcttggct ctcatacctc agatcctcag ggaaatgggc 93540
tggactgggg cctagagcac tgaatcccct ggaaggcccc tgttgacaaa atctctcccc 93600
aaacccgaca aaagcatcac aaactgtgtt cttcccagca cctacaggag ctacacctta 93660
gaacacggat gtttcccagg tgttctttta ctgtcctatt tctaggaacc cgggactcgc 93720
acttgtttga actctagggc gtttaagaag tcactgataa ggcagagcca gatggaggtg 93780
ggatgagcaa gaactgctac tctgaagaga gggacaggtg cacagaagac taatggctca 93840
gtagacagaa aacccacctc tatctacaga taagccaggt gacaacatta gcctcctcgg 93900
cagctgtccc ctcttctgct gagacctatc gattgacatc ctaaatgtca ctgtgaaatg 93960
ttcaagggat actccccact tagcgtagct gctgagccag ggaaggcaac tgaatgtctt 94020
atttgaatgg gttgcctggt gctctccaga aaggttccag gctgggacgg aaccttccca 94080
agtgaagaaa ctcacttcac aagcctccag tccccgccct gcaacaagcc tgtttgttaa 94140
cttgaacttg cggtgacaca caccgagttc atttccagtt tgcgctccag ggcaagtcct 94200
tgactacaca aagagtgaga cagttgggga atttgtggac tgtccagtta atcagataaa 94260
acccgagaga gtcagaaagg cgacttcttg gaagatgtca aagttttact gaaaacagcg 94320
gaagtgttcg cagctaattg gtgctttcct tccacacacc ccgcactccc taccgccccc 94380
tccctccccg cctcccatcc ctgtccagtc cccaccccct gaagtttgtc tttggtaaac 94440
cccagctact tctctcactt gtctctgagg cacaatggga gtcttcatct gaattctagg 94500
gaagaaaaga tatgactcct tctagcacga gtgagctgga ttgtaacagg gaacgaattg 94560
attgattttt cccccccttc atctcaatga acacactatg tagccaaacc aaggctgatc 94620
aacaacactc aataaaaaag gagattcaaa ctgaggccca gctgagccct actagacctc 94680
cacaatgcac gctgtcatct gcttcttaca tgtcatcaca tttaattata ttaatcttcg 94740
ccataagtaa tggaggggat tattatgagc cttggtctag caactgggtt caaggtcact 94800
tagctaatat gtaactctaa atgttacaag tttctaagcc aaggatatgt ccttttctca 94860
ggccgatgct gtcctgctgg ccttctaaaa tgttagttct ctgcctcttg ttctgtgcct 94920
acctcagtgc cccaccccca ctcctgctcc cccccccccc attattctga tcacatttac 94980
attcccggtc tcccattctc ctgatcctgt gtgcttacat cagctagaaa ttatatgcag 95040
gacttttaaa gagttttttt catagtattg cctttttgca tatatatata gtgttctttg 95100
tttgtttgtt tgtttgtttg ttttcaaaac agggtttctc tgtataatag ctttgactgt 95160
cctggaactt actacagacc agtctggcct tgaactcaca gacatcctcc tgcctctgcc 95220
tgacctgtca agtcctggga ttaaagcttg caccaccaca cccagctgct tttatagttt 95280
tttttttttt taagttgtgt ggtgtgcatg ttgttgtgtt ttataaaata gctgtggtat 95340
aatgtttggg gatggggaac atttcagcag gcctctgcca aggcataccc cttgaggaat 95400
cagtcatacc acaggcttag tataaaaggg ataggggacc tggaaaaggg gcagaggcag 95460
agaaggtggg ggacagagga ggacagaaag agagagaggc cagctgggaa catgttgggg 95520
agagatagag agagggagga agggaaggag aaaagagaag agagagaggg ggagggagag 95580
ggaggaggag atgaagagga agggagggag gagagagaga gagagagaga gagagagaga 95640
gagagagaga gagagagaga gagggaggga gggcaagcag tcctttttat acaccaggtt 95700
ggctcacact tggcaagcct caagctgttg ctaggaagct gttggatgga gcctaaagga 95760
actgccaata gtgtgtgtac agatgagttt gtgtgtgcga gtctatgtgt aagcatgcag 95820
aggccaaaga tatcgttcta tatgacaggg cctctcactg agcttgaagc tagtcatttt 95880
ccccaggctg gctggccagc aagcttttgg aatctgcctg tctctgtcct ccaaagatgt 95940
ggttacaggg atacatggta gtgcctggca atgcctggct ttttatgagg atttgaagtc 96000
aggtccccct gcttgcatag taaatgctct tacccactga gccatcacct cagactcatc 96060
ttattaattg tttcagtgtc gctgtatcgt ggacacaaac atatgcatgt atataatagg 96120
gggagagcag attattctgg catttcgaga tcctagccca gtgcaggtgg gtggcagtat 96180
tagcaaaatc actctgatct gatatctgtt tattcatgta ttcttatcta agtgttggaa 96240
gaagaaatgg cacgagaaag cacagtaact tagttcacag tcacaaagct tggcaactcc 96300
tagctgggtg gtgacacggg ctgtacccct atcattcagg aggctcaagc agaaggctcc 96360
cgagatggga gctagcctgg gcgttggagt aaatcccagg gtaactttgg cttgtgtagt 96420
gagttcttgt tttgagagac tcacgtctgg ggagccagag cagtagctca gtggttaaat 96480
gtactttctg tgaaatcata aagatgggag ttcaaatccc agaacctgtg tactgacata 96540
ctggggaaaa cctataaggc cagctctgga gggaggtgga ggcaggagga ttgctggagt 96600
tagttggtgt cttagtcagg gtttctattc ctgcacaaac atcatgacca agaagcaagt 96660
tagggaggaa agggtttatt cggcttacac ttccatactg ctgttcatca ccaaggaagt 96720
caggactgga actcaagcag gtcaggaagc aggagctgat gcagaggcca tggaggaatg 96780
ttctttactg gcttgcctca cctggcttgc tcagcctgct ttcttataga accaagacta 96840
ccagccctga gatggtccca cccacaaggg gcctttcccc cttgatcact aattgagaaa 96900
atgccttaca gttggatctc atggaggcat ttcctcaact gaagctcctt tctctgtgat 96960
aactccagct gtgtcaagtt gacacaaaac tagccagtac agttggcttc cagcgcagac 97020
aggaaaattt gaatcttgat tcagaatgag atccgtcctc aaatgaaaag ccagaaagta 97080
acagaggagg acactcaatg ccctcagtgg gcacgcgcac aggtttgtgt atgtgcacag 97140
aagatggtat actattacca tacttgtttg tttgtttgtt tgtttgtttg tttgagacat 97200
ggcttctctg tatagctctg ggtatgctgg accaggctga cctcaaactt acagagatct 97260
gcctgcctct gcttccagag tgttggggtt aaaggagtat gccaccaccc cctgtggaca 97320
cagatgtatt cacaaatttt caaattgcat ctgtttgttt ggctagtgca cctggcacag 97380
agcgtcctcc acatggcatg gatgaagact tattccaatt ggttattgat caaactaatt 97440
catgaaaaag acagctgtct ttcacctgcc cagacaagga gcaaaaattc atccttatct 97500
tatggattgt gcaccttgca caatccatac aaatattttt tataggaata aagatttggt 97560
tgtaagattc atatattaca gaatgaaaca gggagataca gctctgacaa gattcatcct 97620
tggggatgct gagatgaccc gctgtcccag ctcgctgcca catcctgcct cacctgatgc 97680
tgtttccaga gacctgcttc cagagcagcg tcaggggtgg ctgctgattc ccatgacatc 97740
agttcatcca gcctttcaga cagatccacc aagacttcag ttaagccctg aacattctaa 97800
gcatacaggg actggataac aaatgcgaaa actagctttc ttaactctaa ccaagttttc 97860
ttatttccct acacctccca cccccttgaa aaaaattcat caccccaatt cagcaggaag 97920
tagttatgga gagttgtcat cttgattcct tgggtttagg tgtctggcta tggttatttt 97980
aacattatta tagatatttt aattatttaa ttattattaa attatagata ttttaacata 98040
ttaagggata ctttggaaat gatcataatt ttagacaggg aggaaactag agaggttaga 98100
cttggagatt ctgtcttttt ttttttcttt cctttgctct agccttactt tcttaggtaa 98160
aaggaaggga gctgaaatga aaatggggac tagagtaata taggaaatta gagatgtgag 98220
atggattatt caatttactc ttaaacaaaa cattttatag ttataatctt tcattggtag 98280
aaatctttac attttgatgc agaactaaag ttatattttc ttacattggt acagaattta 98340
tatatcgata caggtttaag gttttcactg gtataaatct ttgtatattg atataaaatt 98400
taaaattaat tctgttactc ttagacaggc attgtgccta tacaactcat ttatacaata 98460
caaggcttag acccagtcct tctaataggt actgtcacaa atggtttaag atgattaagt 98520
gatgcaagtt aatggtcaga tagtaaactc atgctcatat tagattctga tttaattaca 98580
ataaagtgtt ttcaagatta tcacgtagga aataactaag agtaatcaat gtttaacaat 98640
tcaattatat tacatataga tagatggtct tcaaaaacat cagaggtcca caaaatatgg 98700
catttaaaat catttcacta ttaataggtc ttttgactag gagacatgtc tgctcctaac 98760
agtaccccca tctcactgca aagaaggtac tgagtatcaa tacctcccaa ttggagttgc 98820
tttgattgcg atgagctagc tgctggtaag aaatagccta atttaattct acagacaatt 98880
actgtccaga aaggacaaat ggatgcagga cagttgactg ctaagctctg ccaaaacaga 98940
gtaagctagt cctttatatt tcctgcttca tttatggtct atcagatcgt tctggaccag 99000
aagtctgaag acaggtgctc caacattata aggaatattg aggactgtcc aggcagtcag 99060
ttgttcctac aaattgtatt aagttttaga agctatgtct ttgtgctttc tacatattct 99120
gataatttta aattccttct cagatctctg atggaattga aaaatagtta tagtctcata 99180
attgaactta agttatttag cactaaagaa gatgttctag atttgaaagg atggttttct 99240
gagggtattg caagttaaaa tcaagcataa ttgaggtaca gatttgtaaa ttctgtaagt 99300
taagatagat aatagagtac tttatctaaa ttgtcagata tgatgtactg gatgttctaa 99360
gtgtatatca taccttacaa tttacatact tgttataact gtgttcaatg tatatttggg 99420
agaaaagagt ttttaattgg acaaaagggg ggaaatgtag ctgtctaatg ctaattatgt 99480
ttcctcataa ctatttgcat gagagggtct gcacatagct tctgggaacc ttcccacagt 99540
taattctgat tggtaaataa agttcccagc agccaatctc tggggagaag aaaaagaggt 99600
gggtggggct taggtttccc aggtgtggga cctctgggaa gagagaagga agagagactc 99660
aatgcctgaa aggtagtata ggacaaagag gcagagccac cctgtaaagg ggccaggaga 99720
gagtggccca gatggctgct caattgggcc aggagaggcc aagatggaac atagaaattg 99780
gtaagtagta acttggaatt attggcggga ggtagagtct agcagtatgg aggctaggca 99840
gatgcccagc tattgtgctg cttaagtcat attaaaatat aaaggctgtg tgtgagtttt 99900
tcattagaga tcataaacca ttgaggtagg aagtaatgct gtgctgggat ttattaaaac 99960
attaatacta cacttgtggc aatcacagga cagacaactt gtaggaatgg attttctcct 100020
tccaccatgt gggtctaggg aattgaattt aggtagttta cagccttggt ggcaagcatg 100080
ttcaagccag ccccaattta atgattttaa ttaaagttgt tgtcctctga ggcacaaaaa 100140
aaccccaaag ggttcaacac aatcaggatt cctgctggcc tctcatctac agcttgggcc 100200
agaagccttg ctctgttttg catttggaat attttatctc agtctctgta agtcaggccc 100260
agggatgggt atagtcagta cacatgaatt tggtctgcat aactggaaat gtgattatag 100320
cttctcagct gttccaaagg agaagcacca tcatatccca ttctgccttt gtgtgaaaaa 100380
ctcctcaaaa atacatatta gtttgtatct catatatatg tatacatata cacatgtatg 100440
tatgtatata tgcatgtatg tatgtatata tgcatgtatg tatgtatata tgcatgtata 100500
tatgtatata tgatgtatat ataatgtata tatgatgtat atatatcaca gacacatata 100560
atttaggtca ctttttgtcc ctatgtttta tttctttcaa aacctactgc tgcgccttac 100620
acagtgtttt gagaccatct tctttcttat cttttttttc tcacataata tatcctaatt 100680
acaatctcca ctccttctag tcctgctagt tcctcccctc ctatccagag ccacctttct 100740
gtctctaatt agaaaacaag cttctattat atagattata ataagacaaa acaacaccta 100800
acacaactga ataggacaaa caaaaaggca gaaagaaaag agaagtcaca agaaatagat 100860
ccacctgttc acacactgag gaattccata taaactctaa gctggaaacc ataatataat 100920
gtgcgaagga cctttagggt aaagagagag aataaaactg cataaataaa ataaagtaaa 100980
aataataata aaggaaaatc cctgacacag cacagtaaga cagggaagct ccaaagactc 101040
tgttgagttc attctctgct gaccatctag ttctggacat gtaacctacc cttaagagtc 101100
gtttgtttcc acagcaagac tgtcttagag gaaactaaat tttcatttgg aaatggttat 101160
caactggaat tgcttctggg ttaggcctag gggcttgtgt ctacatcttc tctcagctct 101220
agggtccaat cttgtccaga cctgtgcagg tccatgcatg ctgcctcagt ctctgagttc 101280
atatgtgtat ctatcggccc ttgttttctt ggtgtgcccc atcccttctt gctcttgtat 101340
tttgcctcct tttccctgag ccccaaagga agggatctga tggagatagc ccatttaggg 101400
cagagtgctt taaggtctct catttcttac aaatatctgt ctgtgagtct ctgtgttccc 101460
atctgctaag ggaggaagct tctctgatga tggctgacaa gacgccaatc aatgagcatg 101520
tcatcagggg tcattttatc gttacatttt tgtttgctta aaaatagtaa tatttggttc 101580
taccctaggt tcctgaacta gcttgtctca ggttcttggt tacccaagca gtgtcaggtt 101640
tcatctaatg gagaggacct taaatcaaat cagatattag ttggttacta ccataagatt 101700
tgtgacacca ttgccctagt gtattttgca ggcagggcat cattgtagat caaagagttt 101760
gtggctgggt tggggtttac ctctctcctt tggtagtgtg ccttcccata ccaagaactc 101820
tggtagataa aggtgaaggc tctatgtagg caccagctca atttctccac gttcaatggg 101880
ttgtgtaggt gttgtcttca gcaattttta gggtcactta tatatactat catatcatct 101940
gcaaataaac acactttttc ttctttgttt ccaatttgta tcccattgat tttctttaga 102000
tgtcttattg ctctagctag aacttcaagt gctatattga aaaggtatgg agagagtaga 102060
caaccttgtt ttgttactgc tttttagtgg aattgctttg ggtttctttc catttaagtt 102120
gatgtggtct tgctgtaagc tacctttatt atgttgattt atccctaatt attccaggac 102180
ttttattatg aaggagtgtt gggttttaac aaatgccttt tctgcttcta atgagatgac 102240
atgtggtttt gtctttcagt ctgttaatac gatggattac atttactgat tttcatatcc 102300
ctgcatctct gagatggtgc ctacttgatc acagtgtatt atctttttga tgtgctcttg 102360
gattcatttg caagtatttt attgacaatt tttgcatcta tgttctgttt gaatttggtc 102420
tgtagttttc tttccttgtt gagtctttat gtggtttgag tatcagggtc actgtgacct 102480
cataaaacaa attgggcagt gtcccttcta tttctacttt gtagaataat ttgaggaata 102540
ttggcattaa ctcttctttg aaagtctggt agaattcttc actaaaacca tctggccctg 102600
ggatattttt tttttttttt tttttttttt tggttaggag acttttaatg actgcttcta 102660
tttcactagg ggctataggt ctctttaaat tacttagctg gtcttgattc aactatcata 102720
agtggtatgt atagagaaat ctatgtgagc tgaagagatg gctcagcagt taagagtttg 102780
ctgttcctct gtaagacctg aatttggttc ttagaaccca gattgggtaa ctgatagctg 102840
tctgcaactg cagttccaag agatataata ctctctcttc tagacactgg acatggcaca 102900
cacacacaca cacaaagttg aatgcaaatt aaatggtaga taacggtatg tgcacttcag 102960
agtttgtggt aagtgacagt tgatttactt gatgcaacac agagtcgtct ggaaagcaaa 103020
tcttgtgcaa ggatcgccta ggttaggctg gctatgggca aggctgtggg gaattgtatt 103080
agttggttac ttgtggtaag acctatcctg attatgggtg gcaccacctc atagtctcag 103140
tcctgggctg actgaaaagg agtaagctga gccctggcat gtaagtatta attcttggct 103200
ctctgctctt gactatggat atgatctgac tatctgtgtt aagttcctgc tgtccccact 103260
gcccaggagt gatggcccta gcctgcaact gtgagccaca gaaatccctt ttctcttaag 103320
ttgcttttat ttcggggttg ggtggtgggc ggtgagaccg aggttttgtt tttgtttttg 103380
tttttgtttt tgttttgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 103440
gtgtgtccgt gtgtgtgtcc tggctttcct agaactcatt ctgtagacca ggctgacctc 103500
aaattcagag atgggttcct ttgaggcaag caacttctga aggctaggaa ggctcaagca 103560
cattggctcc tgggtccaca gtgctcagca tctgtatttc atgaacagtt cctgggtcct 103620
ctgccagggc tgtaagaagc acggtgtctg cttaatacaa ctgcagccaa agaagacaga 103680
ggtgttggtg caaaaacaca gctctcacat caaagcaggt aatagtttat tctgaagcca 103740
aatatgagtc ccaatggcct agtaatacag atttaagtta cccagcattc tgtgtccaat 103800
gtgctaagat ttggtaaagt ttttatggaa gcagaagaag tttattacaa atccgggtac 103860
ttttcaaaca cattggtgga ggcatcgggt aggtggatca cagcaaagca ggaacaactt 103920
tacttgaggc tcagatgctg acagtgtttc acagcccatt ggttggccgg aaactaagag 103980
ttcgcacatt ctacggaatt tacctaatgg cacatggaag ggcaataaat ggctgtttag 104040
gatcctaaag atgccccaag ataatttggc tctagacttg caacattcta acccctctac 104100
atcattgaca ttctaatcag ttccgtcagc ctttccaggg ctggggggta ggggaggaag 104160
gcaaggctat ttgaggaata gcttcactac ttgaacacca cacattcagg gctgcaaagg 104220
acacacaagg ctctggtctg tggttactag acctctcatc aattcatgag gttgtagcta 104280
tttcgaactc tggaccatct tgtagaggaa tgtgaatgag gctgaatttc cgacatgcct 104340
ttggacagat gttcgtgatg ctaactctag tttttgtaag atagttattc tcttctgtga 104400
agtgatgaag aatttgacac agttttaaag aatctccgtc tctctgactc cgtctctgtc 104460
tcaatctctc tctctctctc ttcaaattag aggtttggta atttaggcac agggctgcta 104520
tatgactctt tgatagcctc acaggcatgt gtacttagtg tgatgctcag cactttgaag 104580
gaaggaagga gggaggaagg gagggaggga ggagagagaa aggtgaaagg agggatgaag 104640
gagggaggaa agaggaaagg aggaagcaag gaactcagtt ataggccaaa gagttttcag 104700
gtttatagac acatagatgg ttgcagctgt agcctggcag tctacataaa ggacacataa 104760
agacattctc ttggccacag gttgctaagg ctgggtagga agtctgtaga aggaagccag 104820
aagtcagtaa gtcacagatt aaacattgag caaaggacca catcattagt cactcaatgc 104880
tagtgtttat ttgtctttct cttttgtttg tataaatgga agtactctct agggtttctg 104940
tttaattaaa aatcttatta aatataagca atgaaactgg cttaaccagg aaactgaaca 105000
ttaaacccgt tcacaaaacg tatgatctga ctaggagaaa gagaaatgtg ctacccacac 105060
caatcctggt tggacatgtg cctaagccga ggtcactact agattcagtc agtacccaga 105120
gaaggtagca aacagccttt gccatataac tgaatgaagg gccagcctca tatctgggtt 105180
tctaactgca gaacacatac atgggtgtgt atcccaggtc aggttgtggg tggcaaggcc 105240
ttgctgctgt ataggggtca gggctcttct tgcatatctg tgtttataac aagagttgct 105300
tctgggtggc acagactagg ggagacagct cctccttcta gtatctttgt caagggaaca 105360
cactataacc ttccatggtg gttagcttaa ctatttcctg tgggtgtgtc ccttattaaa 105420
actatatcct aaatatggtc ctctcttagg aggcatccca tttcctagtc agtcatcata 105480
catgatatac aaagagaggt atcagggcct gggctccatg gctgtctaga tgtttctcat 105540
ctgttgtggg ggatggtgca gcatgccctg agctgcctga gtcactgcag gaatgaggaa 105600
gactcacagg gaggagggac caatttcctt cttcagtaga gtcagagagc tgcataggtg 105660
agatctgagc tgtgcaagga gtgggcaggg cttagatgta gaaaattttt aatcctgacc 105720
tggggcttct accctgcctt tgactcttta gttcccagat agaagacaca cacagccttt 105780
ataattacaa taaaccttca acagcacaag agctgggtgg atacttaccc tctacgttat 105840
tagaatctac tttcctattg ataactctga attattactt actacttaac tatgtttcat 105900
ctgggctgct cttaactcca attggccagc cctcagggcc atgtttttat gattcccaaa 105960
ccatggcacc ttctcctttg tcttctgtac cttctagttc tccttggttc tcctctgacc 106020
catgaggtca ccccaaacct ctaatccctc cagtaattgg ctgtagagaa ttttatttaa 106080
ccagtagctt taaatcaagg gacaaggttt gcagaacaca agcttgtaaa caggagaagt 106140
cttttgtagg ccaagacctt tggctataga atttagcatt acaatgcata gcatcagacc 106200
aaacctcaac acttagaaac tcagcaaggg acaatgtggg caaagacgtg gagtgagagc 106260
cccctcaggg accccatggt cacctgttcc ccattaacca caggtctttg ggattctgca 106320
aacccccagc aacccccagc agctgctgga agcaccatcc catactccat gagtgtgtat 106380
ccaagctttg caattctgaa gtcctatgag acaatgtgag tagtgtgtca ttgtcaggat 106440
tcatgtatat tgtagacaca agatttaatg aaatctttct attgtcaaaa gtgtttctaa 106500
aatgtttgga attacattag agcagaaaga gctccaattt atgttttgct aggtaccttc 106560
ccaacttagt agctttattt atttatttat ttatttattt attatttttg atcatgtgca 106620
ggctcccaaa gtgcatgtgg aagatcaaag gacagatttg tggagtcatt tctcatattc 106680
taccttatgt gggctccaga gctcatactt aagttgttag gaatgtgagg aaagtgctct 106740
acccattgat ctatcctgct gaccctttag ccattttaaa tagcaaccat ttctgacagc 106800
atttggcatc tgaagatcaa gaattcaggg gctccttagc tgtgtgggtc tggccccagg 106860
ctctcaaaag gcagtgagca catcttggcc aaggttatgt cacttgctgt tgaaagatca 106920
aattctttgg gttcagactc catcttagac aaacttgact taagtaaatt aacaggtcgg 106980
tacctagctc cagtttccag attacccaaa acaaaacctg agcttagctc cagtttccag 107040
gctaccccta acaagatctg gatctccagt ttattctcct ctaacaaatc cactgtctag 107100
caccaatttc caggttaatc cccagcaaat cccaacacct ccaggttaca aggccgcccc 107160
tgcctaacaa ccaccaatta ggaggaaagc caacgtttgg ctcccagcac cagccaatta 107220
caccaaaggt cacagtagca ccccaattag atgcttgcta ggcttgaaac actcaccctt 107280
cacttgtgat ttcctataaa accttgtccc agtgagtgat caaggaattt ttccatggaa 107340
ccgtcctgtg ggtcagcagt gaatcaagac ccacgctcga gcttgtgaat aaagtccctg 107400
gtgtgatagc atcggatccg gctccttggt ggtcttttgg agttcatgaa catttcagca 107460
tgatactgtt taactggcat gggcattctt cttgtggtgg gcatctgttc ttcaaatggc 107520
gcatctctgt gtgagtgagt gtctctatgg catggtggtt ggtcgccact gaaatgactt 107580
ttgtagaaga gcaaacagat aaaaggttct tttgtgccgt agtctctgtc aaaccatcac 107640
ttctgctgta ttttatcggc caccctgagc atccttgatt tgatgcagaa gaggattatg 107700
caagcaaata aataccagag gatgtgtacc actgggaaac aaggcaaggt cacctctgaa 107760
ttcatattct gggaagatta gagctttcag aacaggagct gggcacatgc ctgtaagctc 107820
cacactcaga aggccgagca gatggttcac accagtctca gttacacaag tcagttaagg 107880
tcaacctggg ctacttgaca ccctgtccct acaacaacca aatatacacg catgccagag 107940
atgatatagt gaactagaca ccctaaaaaa atttcacctt taacgtattg aaaaatactg 108000
agtagaacat tttaaagatt tattttggtt tttaaatgtt atgtctgtgt atatgtgtct 108060
gagtgtatat cgcatgagtg tatatcgcat gtgtctgagt gtatatcgca tgcatgaaat 108120
acccacagag gacagacaat gtcgccagaa ctctaaaact ggcgttacag acacctgtga 108180
tccaccacgt gggtgctggg agcccaatcc tgatcctctg caggagcaac acaagctctt 108240
agtcactgag ccatctctct agccctaaga gtcaacaaat aaacacacac acacacacac 108300
acacacacac acacacacac ttaaatcttt aaaagctgcc ccattatact atcaggagaa 108360
taacaggtaa aaccaacaca ggaggaggtg tggattgaga gactcgcgga gttgcaggct 108420
ctccttctcc tgctctagtt cccagtagct tactattcat ttaacaatgt ttatggccgt 108480
ttgctaggcc tattcctcat ctaactccta acttacttaa cctgtttaaa ctattctatg 108540
tctgccacat ggctggttac ttctcagtat catatatcta atttcctcag agtgcaggtg 108600
gtgaacctcc cagagtttca gtctgtctac tggaactccc agtttctact tcctgccttt 108660
ggcaaaaaac accatgcggc atatttggtt ttaccccttg acctagaaaa cctcaagtgt 108720
ttatttcctg gccctttatt ttctaaaatg ccaataagat aggccaccag atctttaatg 108780
acaggtgatg cttcgacaca gtacctgaga gattatctct acagacataa gtgcttaagc 108840
tgggggctcc tctaggcaca tccctcaacc accaagtgac agggaagctt ggtgagtttc 108900
tttcacatgg caacaaacaa ggcacctcag ctagcaagca ggaaagcagg agataacatg 108960
tgacggatgt aggcgtcaga gcaaagaccc ttccagaaac tgcctcaaat ctcaatggat 109020
atttctcagt gatagttcac atcaggcttt tttttttttt atgagtacta tttttcttgg 109080
tttattcaat aggctgcttc aatttacctt aatgtccact tatacttata tataagcttc 109140
ttttatacaa gctcagtgga ctcactgaga aagcacaact aggaatgcaa atcagacagc 109200
aatattaata cagagttcac cttctccttt caatggaata aataatgcgt gcatttgtct 109260
ctttctaaat atttaggcac caaaagtttt catgggactc tttctttttt attttattta 109320
cttattaggt attttcttca tttacatttc aaatgctatc cccaaagtcc cccataccct 109380
cccccctccc actcccctat ctacccactc ccacttcttg gccctggcgt tcccctatat 109440
tggggcatat aaagtttgca agaccaaggg gcctctcttc ccaatgatgg ccgactaggc 109500
catcttctgc tacaaatgca gctagagaca cgagctctgg gggtactggt tagttcatat 109560
tgttgttcta cacatcaggc atttcttaat tctctttcca catgcaagga gataaaacct 109620
ttcctacttc tacagtagct ctgatggtca gggaaagtca ggaattataa gcagagtctg 109680
ggtttatatg ggcttgcagc cacgctcacc cagcatgagt tacagaaacc tggctgatag 109740
tctgtttgga aatgtgaccc agcatgagaa gtgttctctg tctagaaaca aacgggagtc 109800
ctgttgaagc acatgatgtc tttggttttg ccccttcgtt tagaaagcct aaaaagatta 109860
ttatctggcc ctttatttat ttttaaataa atgtcaatgt tagttgcaga aatacctgca 109920
tagaagcccc cagttagcct agagttgaaa tacaggaaag atgcatttat caaactaccc 109980
tgtgcagcag aacaaactga attagagacc ggggcaggag gaagcttggt tagacacagt 110040
cttaggcttg gttaaaaaaa gggggggggg gcgttatgca ttatgtacag ttaactgggt 110100
acctgaaata gaccagactt gcttctgagc actgagggct taatggttaa ctataaggag 110160
cctagggagg aagattggtt cgagaacata gttactcctc aattgtgaat ggagttctgc 110220
aaacagagaa cattaagagg aacagaaaag gagaattctt ttggaataat agctctctgc 110280
cacatgtacc caggtgctct gatccccaaa tacatcaaag ctgctttgtc acccagtctg 110340
tgccagaatg ggcttgcaca atgcatctga gcaccgagtg ctaatatgct ctcctgagag 110400
cagcagtggg gagagtctga gctggtggca gtgagctagc tgcagattgc tctgggctgg 110460
tggcagcagg acaagtcaat taggggagtg attgggagaa aggaaggcaa gaggcaccca 110520
gagcctccag gctcttgttt gaaaaatgga agacacacct ggctttttcc acatttccct 110580
aggtgctcgc tagggcctgg tcacctgctc tcctgattga ctcagcaggg attgggttgt 110640
aaaattaggg gctgggtgat gaggcagcaa cttccgagtg cctattctgt gcatgtcttt 110700
gtacatttat caaggccctc aaatcaccct cacagagcag atattggccc cttgttttgc 110760
aaatagggat accgaggtcc agagagaggt actaagacta caaagggaga tgccaccccc 110820
aaatccttct ttctttatct ccaagtaatt ctagccaagg accacatggg agggtgggtg 110880
ggctcagccc agctctcctt ctaagaacaa aaaggactta tgatgtcccc tgggctcccc 110940
atttctctgt gagagttttt aggctcaacc catgaggcct agaccttcct gagaatggac 111000
aggcaattta tggtagctga ggaaaggagg aaacattttc tttagctgtg tgactgacca 111060
ctgatgagtg gcacatgtgc ctataaactc actgggtaac atacacagag gggcatgaaa 111120
aaaagagggg ggctagttga gaagaaggga ggggatcagg agtgggaggg agagaagaaa 111180
ggggagcgat gggtgaatat gatcaatata cattgtatac agggatggaa atgtcatgat 111240
aaggccatta ttatatataa ttgataaatg cttttacaaa atcagaacag aaagataagc 111300
tgaggaggaa gttcagaatc acaaataagt aaaataacaa cagggaaaaa tctttctcag 111360
aacgttgcta tggagatagc cacatgctgt gtgagtggag acctcaggtt ttcctattgg 111420
gcaagatgca ttgagtagct acagtcaggg aaagccagga ggtctgaacc tcgatgccag 111480
agagcccatg cagagttgag aacaggagga aggttctgag gagcccggag ggtggatgtg 111540
ggtgacaact tcagaagaag aagggcaggc tggaagccag tatatggaga cagatgtcat 111600
tcctggacct cacggctacc ttgctgagct cactttctgc cagcaggaga aacatgccct 111660
gaagatgtga agatgccaga gaccggtaca gaaaagcgag aggagcgttg ttgtggttgg 111720
ttgtatgtgc tgacttgatc aggctccagg gtgctcaggt atttagaaaa gcatttgtaa 111780
tggctgtgtc tgcaagggtg tcttttgatg tgtgctaccg tgacctggca gagtgaagta 111840
tacattgctc tccccagccc tggtggacct catccaaccc attggaggcc tgtgttgtgc 111900
aaaatcgcag aggtaggaaa atgtcttccc tctgcctatt tttgagcgtg agcgtgaatg 111960
ctcttgcctg tggagtaaga catagactgg accttacctg tgttagacct ccatgcttct 112020
tggattagga tttggactag aatttatcag ctgttctggg tttgctgttg tgacccacag 112080
gtcatcacac tcctcagcct ctgtagcact gtgagaccat tagttataag aactcctgga 112140
gttggagaga tggctcagaa gtgaagaatg cttcctgctc tttcagagaa ctggaggtca 112200
gctcccagca gctgtatcac catcacgtga cttacaaaca cctgtacctc cggttccaag 112260
ggatcaagtg ccctttcttg cctctgtggg cacccagaca tgtgcataaa cgtacacaga 112320
tatacacata aataaagtaa aataaaataa catgaatctt aaaggaagaa acccagtcaa 112380
tcatcaccca tcctgcctgc atcctcttgg ttctcttttt ctctgggtca aatggattgc 112440
cccatacaag catcttcttg ctgccttctc tacaggctgg ggctaaacag ggaagttatg 112500
ggtggggaca actttcagac agatcaagaa ggaggaagga gcgactcatg attttcaaag 112560
acaacacaaa tgttggcagt ttggggatgt aaccgatgag ggcagtggac tcaggggcag 112620
acccgtgcgc atgcgcccac gtgttgccat ggcaccaaca ccatgcgctc aatgggatct 112680
agccacactt acgttaatgc tctggtacta cagagttgga acttttagta agtttgagcg 112740
aggagtaata tatcagtggt gatgagcatg cagggttagg tcccttagag aaatggtgac 112800
tagggtggga agtgacacag ctgttgccat atcaaggcta gagagttgct ccaccgaata 112860
gccataagtc ctagtatcag cctcagagtt caggaactct gcttttcttg tttgtttgtt 112920
tgtttgtttg ttttcttcag acgattctgt gaagggaaga tggaaagtgt taattatata 112980
aactgaagac gtttccctgt gaagtaaggc cagcccatac ccagccttag gctaagtttc 113040
acttgccctt tcgcaacaca aacctttgtc cctagatctg actaagaggt taagcaatgt 113100
gaataccggt ggccaggccc ttcctctccc cagaagagag aagaggtccc cgaggcagca 113160
gatgtgagtc aagtgccttg tggtagagga ggccactgga gtagacctgg gaaaaggttc 113220
tgacactgtt tatgactgtt gggctgggct tgatcagacc aagcaccaaa cgcagagcta 113280
tgtatgcgca gctctgacct tcctccaggg aggatttcag gatgggtgct catgaggctc 113340
cactcctcta tgagtatcgg taggcaggat taatggttgc cccagaaaag taatgttttc 113400
ttcagtggtg tagctactga taagttgccc atgtcattgt aaataacccc tcactcaggc 113460
tcttgtgatt aattcactgg ggcacatgac atcaatgaca tcacacatac acacacacac 113520
acacacacac acacagagag agagagagag agagagagag agagagaata ataaaaaaat 113580
aaaaatttaa aaatcatcta gtctttgtta ataaggataa tatacttggt ggtatactta 113640
aaattggtgg caaaaaatca tgcccgtaag taagcactgt ctgagggctt gcgaaagttt 113700
ctaaacctgt agttacaggc atcctcaaca aaaggcatgg caagtcattg acattagtgt 113760
cacccaggca cacagccaac tcaggtggga attgttggct ctgtaaggac aggcaaagga 113820
aaaggtcaca ctcaaatggc tcatctctgt catccttagt agaaaaaatt gaaaatgata 113880
ttagtcaaga aaggactaaa taagatgata tgcctaatat tcagggagac caggataatg 113940
tttcaaatgc cctggaataa ctggctctgt gtgtgtgtgt gtgtgtgtgt gtgcgtgcac 114000
gcgcgcacgc acatgtgagt gcacagattt atgtctgaat ggtcttcaga aattaggtga 114060
tattccacag gaaggatttt ccatcctatc aagaacctaa gaatatttca aggaaccaga 114120
tcactattta gggaagaggg aaggtcgtgt attatattag ccagatatac ttcactcaga 114180
tatgattttg gattacacat ggtggtgcac acctttaatc ccagtacttg agaagcagag 114240
gcaggacagg agacacccag ggccaacgag acccacatga atgcacaccc cctcatgtgt 114300
cagtgagagc tctcgcacac tctccctctc ataatgagaa atgagaaaag gagaaagata 114360
aaatatctgc tattccttgt attagtcaaa aaacttcctg cgtttgagga tagcttcgtg 114420
tgtacttaga tatttagaaa gtctcaggta aaccagtgct taatagtttg tctcaaacaa 114480
acaaacaagc aaacatgatt tgaaccaatg gcattgggta ggaaggcttt gggcttcaga 114540
taacaaagct gaaggaaggt ctgctctagc cacagctgaa cgtccagtcc tcttctctaa 114600
caggaagtct gcaggaagtt gctctccaag tccacgcagc acttccaggg cgtaagcagc 114660
tcagagtctc tgaacttgcc tgcttgtttc gctgcttcct cttccactcc aggtgggaac 114720
cacggctttg agcgacagag tctcatatgt cagcttcttg aggcaggaga gagagagtga 114780
taatgctaga ggattgtctt cccccttccc cccccccccc gccccactct gacaggaaga 114840
gccttcgcca ccgtgacaac ctgcctgcga tcatcttaac ttagtggata gaccctcaga 114900
cgagtcactg gctgacaaat atagacaccc atgattggct tacagcatag tgttcattgc 114960
ttcctttctt ttccatctgc agtccagtgg ggaccattaa aactaagtca aagggaaaac 115020
tattcatggt tttttaaaat ttttttaaat tttaaagaga gaaatatgaa gggctaggga 115080
gatggctcgg gggtcacgtg tgtgttgtac aagcatgaag attagagtat tatcttcagc 115140
aagaaggtaa aaaacctgga tgtggcaaga cctgtaatct tggcactggg aggtagagac 115200
cgaaggatcc tgaggcttcc tggtcaatca gcatagagct tcagatactg tgagaaaacc 115260
aaatggcaga gagggataaa agaagatccc cggtgctagc ctcatggaca tgcacacaag 115320
catgcaagaa tgcacacgcg cgcgcgcgca cacacacaca cacacacaca cacacacaca 115380
cacaatcata atgagagtag agaaaagtag aaagaaagac agtttattat tccttgtatt 115440
ggtgaaaccc tccactaagg ggcaaaagct attgtacacc atgaacacct gcaggctcaa 115500
cccttgggtg cagagggaga agactgcaca atgaattcca caccaaccat ggagaaacat 115560
aaattaacga acaaatagga aagcaagcaa aaaaaaaaaa actagactgg aaggagggat 115620
tctgggtcat ggaaatatca ttcgccattg atgaatttta tttttatgtt catttttcag 115680
ctccatccct actccttaat gtcgctgcca tgttcctgtg ctatggtaaa tctcttgatt 115740
taaaccaaaa gctttcctta cttcctttca gaatttcact tacgttactc tctctcctct 115800
ccctcactta caatgaataa tcttggaaga aaacatgtct gcatagaaaa ggactttctg 115860
gttagttcat aatgttgttc cacctatagg gttgcagatc catttagctc cttgggtatt 115920
ttctctagct cctccattgg gggccctgtg atccatccaa tagctgactg tgagcatcca 115980
cttctgtgtt tgctaggccc cggcatagtc tcactagaga cagctatatc tgggtcctat 116040
cagcacaatc ttgctagtgt atgcaatggt gtcagcgttc ggaagccgat tatgggatgg 116100
atccctggat acatcactgg aaagagaggc ccattggact tgcaaacttg atatgcccca 116160
ggacagggga acgccagggc caaaaagtgg gaatgggtga gtaggggagt gggggtgagg 116220
gtatggggga cttttgggat agcattggaa atgtaattga agaaaatacg taataaaaaa 116280
atattaaaaa aaaaaaaaga aaaggacttt ctaccttact ggcaactgta ggctcttagg 116340
cgagggctct cgcctcagtc atacgcgtct tcctctctgt aaagtgagct ggctaaatta 116400
gacacatccg aaggtcacat agccccagtt ctgaaacttg atggttctaa agtctgcggg 116460
gacaagcaca tgacccttct ccaacctctg gtatcaggtt ctgttcccac tcgttttatt 116520
cattatctgc tctgtcccct acttaaccca gacttatttg tgcagtctct gaatgagcaa 116580
gccaggcttt ttttttttgg atgatattat tagatgctcc tgaatattct ccaagtgctt 116640
taaatgaaaa ctctggacag tacagccaga cttcccaagt tgccaacttg tcccaggcct 116700
tagaagtcac ctaattacat tgaattctgc ctggtggaga tgaagacaga aagcctgtca 116760
ctaatggtgc atgtgttgag ggtggtgacc actccatctt tattgccagc tatgctaaag 116820
cccttgctgc atcagaagga gtgtgagctt gtaaagttcc gagtctgcag catgatcttc 116880
cattctctaa gcggtaaggc ttaatgtgtg tgtgatgctg accagtgaag gaagattcta 116940
gcaatattct gaaagtgata gataagaaat caatactaaa atccatggct gagaatccgt 117000
ctttggttaa tgggtagcca cagaaggtgg gagagagatt tctggatact tcaaggagca 117060
gaagaataag atcagccaga ggggctgctc tgagcatcga ttgctgctgc tgctgctgcc 117120
cctgccgccg ccgccgccgc ctttgtcgtc tttgtgtatt ttgtggcgct aaaagaatag 117180
caagcaccag gcagcttcta atgaacaaat gcttgtgatt ctggaggcca aatccaaaac 117240
tgagatactg acatctggag gggccttctg gctgtgtcta atatcgtaga cctcatgtgg 117300
cagaaccaca aatggagaga gaaaactaaa agggtccaca ctcactcttc actaggaatc 117360
cactcctgca atggtggtcg taatcccctc accccattct ttcagctgaa tctttttttt 117420
ttttcatcag gttctgccgc ccaacgctat tgcgtaggga gtacttctag cacatgctta 117480
tgggagtgtg ttatcatcac aagagttggt aactttcaag gagacagtgt gagggaaggc 117540
tgtagaaata tttaagaggc aacagacttg gtcagtcaat gaagccagaa ctctaagggg 117600
aagtgtgatg ctcactaaag gaaacataaa ggactccacc cctacccccc acccccgggt 117660
gaacagaact cttctgtgct gtcccagcct tgcacaacag caacactgat accctactcc 117720
cacagtgaca gaaaaggact tgggactcct atgaaggacg agggacttga ctagagctca 117780
ctaccttgac ctttcactgt tagaagtggc ataaggtgaa gagctacagc ttaggggctg 117840
gagtgatggc cacttgctgt tcttccagag gacccaagtt cagttcccag cacccacatc 117900
aggcagctcg caacaattac ccatgattgc taccattgat gctgatgcct tcttccaact 117960
tctgagggta cctgcattct tgttctctct ctctctctca tctgtaaaaa tcatattaag 118020
aaaatatata tttgggttta aaatcaaaat ggaagataca ggttatagag atatatttag 118080
caaaggaacc aagaacactt gatttctgtg ccagagagtc acactttcct caaagagctc 118140
ccaaggagaa acaataaaaa taaatacagc tcttactttg cactagatgc tgttaggagc 118200
actttaactc cattagctga ttttgttctt ataacagatg ccagggcaag agaaagctgt 118260
atcagtcact tgagaattga agttgatttc atggcaggcg gtgggacaga gagaggaaag 118320
tgggctggtc cttacaaagc acagatgcag aaaagttaca ctgggagaca aaaatgagaa 118380
gagatgcaga gtagcctggc tagctggctg ggttcattca tttactcatt ttacctttat 118440
tgagatggtt agagggtaag tctgtgctca ccatagtgac aaacttttaa atgatgcttg 118500
tgcttcagcc ccctccagta tcacctcagt cttatcattc gaacacttgg tcctgacggg 118560
ctttgctttt tgaccttgta cattttttta aaaagcgatt tttatttctt tttatattat 118620
gcctgtgtga tgtaattgtc ccacatgagt gccacggcca cgggagcctg aagagagtgt 118680
ggcatcttct ggaactagag ttacagattt gtgagccctg tgtgggtgct agaaaccaaa 118740
tccaggtctt ctgcaagagc agcaagcact cgtagctgat gagctatctc tgtagcttcc 118800
ggataattat tttgatgaca aatgtctacc tgagcctcca tttataacat tgcaatcatt 118860
cctagagatg tgcactagta gatttgtaca atagagtgca aatcagcata tttcatgaag 118920
acttaaaagc ttaaggtcct tcagccattt ggaatgggca aactgctggg acatttatac 118980
catgcagtgt tgtatagcag agaaaatggg tgaatcatca ttacatgtga gtgaagggct 119040
ggagagatgg ttcagtggtt aagaacatgt actgctctta caggagctta gtacccagta 119100
ccatgtcagg cagctcacaa ctgcctgcag ttctagctcc aggcgggaat cgaatacctc 119160
tggcctctga gagcaggcat ataccaccat acacatatat gcataattta aaatgaaaat 119220
aagttttgaa aacaattaaa aaataacagg atgaataaag actgaacaac atgtttgagt 119280
ctatgccggg gcctagcaaa cacagaagtg gatgctcaca gtcagctatt ggatggatca 119340
cagggccccc aatggaggag ctagagaaag tacccaagga gctaaaggga gctgcaaccc 119400
tataggtgga acaacaatat gaactaacca gtaacccgga gctcttgtct ctagctgcat 119460
atgtatcaaa agatggccta gtcagccatc agtggaaaga gaggcccatt ggacttgcaa 119520
actttatatg ccccagtaca ggggaatgcc aggaccaaaa agggggagtg ggtgggtagg 119580
ggagtggggg ggtgtgtatg gggacttttg ggatagcatt ggaaatgtaa atgaggaaaa 119640
tacctaataa aaatattaaa aaagaaaaaa aaaagactga acaacaaaaa caaaccagaa 119700
gttccaggag aatattggct ccgcacttta tcttttttaa ggtccaaatg ccaaaacagg 119760
tatttaggta gttgttgtct aagccatttg ttgccgattt aagtaaaagt ccatccattt 119820
tctgtgcctg ctaaaattga tacttttaaa gcaagaaaat gaaacaggag gaaattcaag 119880
gtggaggatg tctcggtgga gcaggagggc gtgaagagag agcacacgga agtgaggctg 119940
ttgaccgtgt tctcactgtg ctgggcagtt gagacataga tacttatttg gaaaagaatt 120000
aaactcgagg gactcagtgg aatggaaaaa gtcagctatg ggtggaacac cagaccattt 120060
catgaactgg gacttgtaaa tgttctcatt ctggcacctg ctgagctcct agtgacataa 120120
gagacctaag ctccagattt attccgaatt aacaaattga gccagatcct cagatctcgt 120180
ggaagaacaa gcaggtgctc tcgactaatg agccacctct ccagtcccaa ggtatagagc 120240
tttgatctcc atttttcttt atgtacaaat atttccctag gcattaaagg tgtaatttcc 120300
ataatctatt cagtgtatca ggctgtggtc atactgaata agaggttttc ttcacagaag 120360
catcctgtac attaaataga aagatcaatt ttaaatgaca cctgagctta ctccagtgtc 120420
tctgctaatt tgttgaactt ttccttcata atctctttaa attaattatt aactagccca 120480
aagcagggtg gacttgggca ttatagagta cctggtcaat ttagaaatcg tttagtccaa 120540
gtcattagag gattattacc cttttttttt tcttcagcca gatgggggat gtcataaatg 120600
tacacaatta gggttcttta aattaggctt atggcttgga tgtgaaatgt cccctagaag 120660
ctcacatgct tgattacttg gtccccagct ggtagcactc tttcaggagg ttggacagac 120720
acacagtctc attcatagtt ggtggggcat agggatgaaa cttgagggtt acggatcgcc 120780
tctgattctg tcctggttgc tctgtttcca gatccagtca catgtgagca agctatctca 120840
cactcccgtt gtcataacgg actggttctg tttccatgtg tttctcatgg cggtgatcga 120900
ctttatcctc tgaacctcgt gcaaaccctc catgactcaa gttggtcctc ctattaggtg 120960
tttgccctct gtcatgagaa gagtgacacc catagtaggc tcctttccat ccatctcgca 121020
tgtgccccac ggtcaggttc tgttggtcta aggctgacca tcaactgctg ctgaacatat 121080
atatatagtt gagaaacttt tccagtcata ctttccaaga aataaatagg agcttgagtg 121140
tggtgagctg tagctctcag ctggccactg atgtaattat taatcactgc atgcaattaa 121200
ttgggacctt tcttagacat gtttgccact gatccctgtt tccagggagt ttcacaaatg 121260
ttcccacccc agcctcgtac ctctatttgt tcttttgtaa ctttataaaa attttaatct 121320
atacaagttt gcaatgcatt gatcatatct attcccaccc tcaccttcct ggttatccga 121380
gattctcccc accatatccc tttgaagtgt cagatcttcc tcttctgctc tttataacct 121440
actaagtggt gttcatatgg gcacaggtgt aggaacattc accacagcat gagcaacctg 121500
taagagacca cattcctgaa gaaaactccc ctttctcccc aggggacatc aacggccaat 121560
aactctcagt tatggatggg gtaccttccg tttatcctgg aatgttgact ggatgaatct 121620
gtgtaagcag ccactgctgc tgtgagttcg ttaagtgtaa tggcctcatg ttgaagttaa 121680
gccctggatc ttcctccaag ctccgtgctc ccggaaataa ggctcagact caaaatatat 121740
ttacaaatac cttggccatg taactaggct cttctctgac tagctataac ttgaaataac 121800
cattgattct agcctacatt ctcccatgtg attggcgata tgagctcagg taccaggcat 121860
ctgtcttgtc acatcttttc agtgactctc tctgcctcct tctctcccag aattctttct 121920
cctcccacgg ttcaccttct atttcctgcc taagccatag cccatgggct ttttagctga 121980
caggtgatgc attcatacag tagacgagat gttctgttta tagccttgcc atacccagaa 122040
gacactgtgt cacaacagtc actccccatc ctgacctgca gcccttatga ccttttggcc 122100
ctctctttca cagtgttccc tggggggtgg taatggtggt ggtatgcata tatgtcctgt 122160
tttgagagca ccgcatggtc attccacatt tgttcttaag tggaagaaag catgatgcaa 122220
aacagaagga gtgagctaga ctttaactgg atttagggga ctttataaga gaaagtaaaa 122280
acgtcctcaa gaattcatta aaaatgaaga gcatctcccc catgctcatt tctgttcatt 122340
acaaacgact caactattac atgcaaatat tactctagga aaatagccac ccactgatat 122400
gggtgtggag atctccaaag acaagaggaa gttgaaaagg gctcagatgg ctcctccaat 122460
gtggccttcc agcttatgac aagagaaaca caattgctgg tccagggaca gatgtctgct 122520
gcacttgctt tgttcctggc tctccctctg acccaattta cagcccccct gcagctgtct 122580
cctgcatact ttcccacgtg aagttattta tctttcttaa cagtcaactc gatttattcc 122640
aagagaatgc tcccctcccc cagctctgct ggtaatctat tcctgcacta aattgccatt 122700
gtaatcaaaa ttcctagaat agtttaagtt ggccttctgc agctgcagtc acctctgtca 122760
aagccctggc caagcctcct cagtgccctg gagtgagtgt cattccacat tgctggaaac 122820
cacaccccat ctggctcttc ccgcctttcc aggctccttt tgctgtgtcc ttttatcatc 122880
tctactgaac cactttcctg acaaagctcc aacacggttc ctcctctaga gctaccgacc 122940
tcttcaactc ctatgtggtc attttttttt ctgtccttgg ccatttctta acccattttt 123000
ttaggacatc ctcttctctc cttgaaactt ggtcagatct gccaccatat gtaccactta 123060
ctcaatattt tgatcccgga gctcagttcc gtggtggcta attttgtcaa cagacaacat 123120
ctggaatcat ctaaaactca agttgctggg cacttctgtg aggcagtttt ttaaaatcag 123180
attatttgaa gcaggaagac acatccgaca tccgggcccc actttctgat ggcagcccag 123240
ataacatgac gtggaagaag gacacttggc tttttttttt tttttttttt gcctgcttgc 123300
cccactgtgt ctggcatctc tcctgttgct caggcattcc ttcactattc agaatcccaa 123360
caaagataga aaaccatctg ctctccagga atcctccagg atcccagagc taggtgagga 123420
ctgctgagac acccagcctt gtggactgaa cagctgccag tttagatatt ggtctttcca 123480
tcatgagact gccattgttg aactactcgg accatatcct gtaagccagc cttataaatg 123540
catacacaca cacacacaca tgcacacaca cacatgcaca cacacacaca cacacacact 123600
cacactcaca catgcacgca cgcacacaca cacatgcaca cacactcaca aatgcacgca 123660
cgcacacaca cgcacacaca cacacacaca tacacacatt cactctcagt tctgttcctt 123720
cagagaagcc tgactaaatc aggttcccag cacctatgat gggcagttca caatggcctg 123780
ctaatctagc tctgggagat ctccttgctt cttctcatct ctgcaggcac tgtactcatt 123840
gtgcacacat aaatactaat actaataata atagtaatga aaattataaa ttcatatgca 123900
taccagtttt tattagttgg caacagattg cataaccaca acaccacttc acaaccagaa 123960
aattgacaga ctatactagt catatccagg tttcatagtt ttgccctgtg cttagacatg 124020
catattttca gctattcatt gattgcttgc catactagaa actgacctac acaggctaag 124080
ccagtgctct accgctgaga tgtatcccca gccttctggt tccatctgac ttaagttgcc 124140
caaggtagcg ttgatcccaa tctgtaacac aggcatacct gaaacttgca atccttctgc 124200
ctctgtcacc tgcgtagttg agattttagg ccggtgccac tctgtctgta actttgttat 124260
gtggagagac tcgtgtgcct ctctatgaga tacacttggg aagaaagaac ctgccggtta 124320
agggatggcc tccatcaggt tgcctatggg gatgtgtgtg gtaccttctc tgtccagttt 124380
actacgggga gcatcttccc taggcaggtc gcttaggttg tctaagaaag ctagctgaac 124440
acggagcaaa ccactaaagg gcatccctct gtggtttctg ctttaaggtc ctgctttcaa 124500
tctgtctcct gtcagatgaa acaaaccctt tcctctccaa attgcgtttg gtaatggtgt 124560
ttatcataga aaaagaaaac cgagaaaaag aaaaccacca tagtcaaact tagactcgtc 124620
ccatcagtgg cctcttgtga taccttttag aaccaactgc cacctgtccc ttctcccgac 124680
ctgtgaccag caataatatg tctccagatt tatactttga ttaattttaa gaatgttgca 124740
taaattttat caaacaccat acggaagtct gaaatttccc tccccagcat gattctcttg 124800
atatccacct gagttgttgt gtagaccgac actgttctca ttgctattgg tgagtagtat 124860
ttctgaatgt ggacttggta gtttgtctaa ttgctcgctt gttgtgagat gcttgggtta 124920
tttctagtta ttgaaaatca acatatatga aaatgcatat gtagattttg tgcactttca 124980
cttctcttgg ataaatgcct taggaaaatg ttttctgggt catatggcag gcatatgttt 125040
gatttcctag agacatcaat gcagttttta gactgattgt cccattttac attctcagta 125100
gctgcgtatg agtctgacat ccttgccagt gtttgttgat gtccttaaat tttttgaacc 125160
attctgatag tagggtagga tctctatttt atttatatat gtgagtatgt gtttgtgtgt 125220
gagcatgcgc atttgtgcat gtatgtgtgt atgtgtgtgt gtgtgtgtgt gtgtgtgtgt 125280
gtgtgtgtgt gtgtgtgcat gtgtgtgtgg aagaccatcc tcacccttgg agctggagtt 125340
ataggcaatt gcgaaccaca tgagatggga agtgaactca agtcctctgg cagagtcctc 125400
tgtgccccta accactgagt gacccctcaa ctccttagtg tatcatactg tatgtttact 125460
gagtgtttct atgatggctt atgctgttga tcctcttttc atatactact ttgtcatctt 125520
tatagcctct ttagtggcag atctgtcttt tctaagtttc ctagtctaat attttaatca 125580
ctgagttttg acggttcttt atatgtctta gatagtgcca acctccactc tgtttagatg 125640
agcagaaggt ctatggggtt aaaaggcttt ttcagtcatt tagcaaccga gaaaggaaag 125700
atccaagtct gcccctgtct ttatgcagtc tttaccatgg ctcatctcat atgtagtgtc 125760
ttcccaactc atcaagctac attcatctta gcatacatag tctcccaaac caaaaaccca 125820
taaccagggt atacatcctt ttggtgggga attgtctgaa gtttgtcttc taaagtgtcc 125880
agcctgtgtt agtcattgta tcgccctata tagtcaacag gggtggggat ggaacacaac 125940
acctaagtat ccctttagcc ccgaagagcc ttcagttgtc actcctcatc aaaactattt 126000
aactagagtc atctcattca aattcaagtc cccttgccag attaaaatat agctgatgag 126060
tagttatcat gaaggtaaag aagccagtca cacggctagg gagatggtca atgggtaaag 126120
tgcttgactt gtaaacccta ggacccaaat tcatgttccc agcaaccaca taaagtcaaa 126180
cgtggcatct tgtttctgca agccgaggtg tgaagggtga agaagtgaat cccagggact 126240
tcgggtgggt caatctagtt gaagcgatga gttccaagtt tagtgagaaa caacgtcaaa 126300
aaataaggaa gaaagaaatt gaggaagaca ttgtgatatc atcctctttc gtgtacatgc 126360
acatgggtag gtaagcacgc accactcaca cacacacaca cacacacaca cacacacaca 126420
cacacatcaa ttcttcatag ctctaagtgg attctttttg tcaaagaatc agctgaagct 126480
taatggagat tgcatacctg agctcttgtc ttctacaggg attgtaagag caatgcccag 126540
atgactctta tgtacacagc tgtcccagag tctgttttct aatcactcag cctgtgaaaa 126600
ctggtgccat ccatgacttg aacaggctgg tggtcttggg agccagatca ctttcccagt 126660
gggcactgag gagctccacc tgccaccaga tagcagagta ctgattaggc cttgaaccag 126720
aaatgaccag aaaagcatgt tatagatgag aatagtacag tggatgtcat gttctaggtg 126780
tctgagaaat atggaggaaa atgaccctaa tcataaagaa attatagggt agatattaag 126840
cacgcctaaa ttattaacca gacaataaga ggacatgaga gattaattga aggttaatag 126900
ctcattgtga aaggcagggg cctctctggt agcttataaa gatgctcttg gcttttgcaa 126960
cctgaggcct gagaaattgt ggcctatgac ttaatagtaa gaatggtgga acaacaatga 127020
agggttaaga cctgaagtga ggccatgtca taagttgttg ggccattgtc ctcacccagg 127080
ttaggaaaca atggaatttg acacatatgg caggagtgga ttatgtcaaa aacaataaaa 127140
ctgaattgaa ttaactgtat tggatctaga gttgtttttt tttttttttt ttttttaaat 127200
tctgtgctgt aagcttccag aaaaggcata ctccttcctg ttaaacacca gtgctcttct 127260
gatgtatcag gactgtatta gttacctctc tgtgactgtg agaaaacacc atgacaaagg 127320
caatttgtag aaggacgggt tttactgggt tatagttcca gagagataag agttcattat 127380
ggcaaaaaga gaaggctgga gataggtatg ggagctgagc aggaagcgca aaggccaatg 127440
gcaaacatga agcagagaga acaaattgga agttgggtaa agctcaatgc ttgttgttag 127500
tgatgcactt cctccaggaa agttatagcc ccacactccc atcgcctctc caaacaattc 127560
tgccaacagg ggaccatgtg ttcaaatgcc tgtgggagat agttcacatt caaactacca 127620
caaaaaccat acagtgctcc atgagttagg aaaacatgcc tgctttacca gattctctcc 127680
tggtcaccaa gctaaaccct aaggatatat caccacaacc tggcagagga ctgagcttgg 127740
tctggtaatg gaagaaggta taaaccaaaa ggaacatcag gtcctagcca ttaccataag 127800
tgggactgga ttgtgtaagt tttgcctcaa aggtggcatt attctaagtt agatgatgga 127860
ggatctgttt cttgaggcag ggtctccttg gatacaggag ttaccatcta tcaagatagg 127920
ataaagctgt ggctggcatg aatagaatca tgatagatga tttaaagcct atgtggggga 127980
tggaagcagc ctcccctaaa gtaaaagtgg aaatgcatta ttgtcattgc tatggatgct 128040
ttctgggcaa taaaagacag tgggatatga catacagcta gaagtcttat ttaataattt 128100
ctattatgat gctataatgc aaagcatgga gatacggaca gatacgatga gtactggtat 128160
aattaagaaa ttcagcagta aatagctcct gaagtcattt ctaatcagag atgtcattgt 128220
ggagattgtg gagattgtgg attgtgacac agataggaag atcccaaatt aacagccgca 128280
ggggttccat ttcaaactta gatgccaggt gacagcattt accaaaacag aaggtcaagt 128340
gcaaaagaac aatcaggaga tctgactcca agataacaat ggcaattgtc aacacagctt 128400
cctagcgttg gggagaaaag agatgtcaag agacaataaa accattgcac gcaccagagc 128460
aagaggagcc aagagtgtat gagcaagatc ctagagacaa ggtttctcca cagtgtgttc 128520
tgtcacccag gttcagagct ggcccagttt tcaaacacag aacccaacga tgaagtgatc 128580
aggtgtcctg gaaaaaaaaa aagatttctt caaaaccatg gtgacttaac aggtaacaat 128640
tccctgacac ttccctgaag caatcttcaa tcaccaactc agttagccat aagttatggg 128700
aatgtttggt tccaaacatg tcaacctgac acaggatcat acacagattc aaagtatcaa 128760
catgaacctt ctgttacact gggagcacac ctggccatga atggaagctc agaacagttt 128820
caggattaca atgtgtccac agagtaggta ggctcaacca gtgatcctct ctcctgtccc 128880
agaatgtaac attgaagaag tgcacttggc attgggccca gcttgggttc ctttacctgt 128940
ggatgaaact taatgaggga aacattaata acattattaa cattaataac ataattaaaa 129000
cataatgagg ggttggacag aagcaccaat gagaaccctg ttgctcaaat ctgcccctta 129060
caaaggtata aaatgtgtgt tctttctttg ttctgggtct ctcctctggc ctgcgtgctg 129120
agaggggagt ccccaacatg ttggatcaat aaaaatccaa taaggccaca ctcctaatag 129180
tgccactccc tagcccaagc atatagaaat catcacattc cagtctctga accccagagg 129240
cttgctcaaa catatgggac ataactaaac ctaacataat gcaaagttca tttagtccaa 129300
cttccaaagt cctcatagtc tgtggcggtc tcaacaatgt tttaacttaa tcttttaaga 129360
ccaaagttca aggtctctac tgagatttac tcaatcactt aactgtaatc tccaaagcaa 129420
gacaggaaac caaatgggta aactccaaac tttggatctt catgtctgat gtcaaaactc 129480
tcttcagatc tccaacctct tttttatctt tgttgactgc aacaaacttc tttctcttgg 129540
gctggttcca ctccctgtta gcagatttcc tcagcagata gttcatggct ctggcatctc 129600
aaacatcttg gggtctccaa ggaaaattca atgttacagc ttcttgtttc aatgtctggg 129660
atccacacat aatcttctgg gattctccaa agggctggtg tcacttctcc agcactgccc 129720
tcggtggcat tctaagttca gagtgatcca ctccactgtt gctgctgttc ttggtgatca 129780
tcccatggta ctgtgttgtg tctgctcttg accagcaaga aagacacaac ggccagattc 129840
ttctcaacag cctttattgc aggaatgcct caatgctgct acagggacct agggaaccca 129900
gggaggtctg cttatatact ctccagcaca gggaaaggct tcatggcccc ctgggattgg 129960
tcagtctgcc ggcacctaat ttgcatgcac ccgctccgga ggggttggcg ccagactcgg 130020
acttacatct gcgctgatgt tgtttatgac aatggcacac ctggtgccca gagccatctt 130080
agagttggct tcctacagta ctggtatctc caatactctg gggccttcta ctgcaacgag 130140
gcttcaccaa taacctctca taggttctct ccatggtgcc aagcctcaac ttcttttcat 130200
gaccccttca gtcctgggct gtcaagtgca actgaggctg catcttcacc aatggccttc 130260
catggcctct cagagtgcca agcctcagct gctctttatg ttcccttcat cccttcaaaa 130320
ccagtaacac ctgagtgatg gggatggatg tagatgaggt gaaacccaga acacctctca 130380
ttccctgcaa gggaagaccc atgcctgtag ccagaaatgt taggattaga gcaaaaccct 130440
tagtagaaac tgctgtgatt ctcatttgga agaccatgga ctgatctgtc agcagtgtta 130500
ttggaggtag cctttttctt tctccattgt gaagttgatg gtccttgggc agacttcaag 130560
aaagggtctg aggagacaga cccaggaaga gtgtagcaat aacatttgat ttgcgattaa 130620
gaaggctgga gtcataatta gccctaaatg ggacaactct atcaccctct ccaatgctca 130680
gggaagagga gacagaaaga atgtaaaagc cattctgggc ttgacatagc tgttgtcttc 130740
atgtggtgac ctgcactaga gctgcaggcg actgggcatt catcaagtgt gtgggagggt 130800
cccctgaggc cccacccctc ccttcaggac taacagaagt tagtgcttgc caagggagta 130860
gctatcatcc tctgcagtga cacggaagct gacaagttac ccatgctcca ggaaataaac 130920
tcccacccac gctcaggcag gcgacttacc ttagactgag taagtcacac acaaaagaag 130980
acatgaaaga aggaggggct cttcgttgag actaagggtt tcaagtggga gaaagagaag 131040
gataagacta ttaaaattca ttacatacag gtatggaact gccaaagaag aaaatgatga 131100
agagcagcag ctgccgccac cgggagtgag tcagaggtgg cctgcaagcc tgcaggaacc 131160
tggccctcac caacagaaaa ggcggaggac agacacctga caagagtgtt ctcttccctc 131220
cactaagtgt cttttacagt ttacatgttg atttgggaga ctgttaattc tgggatatgc 131280
ggggggtggg gtggggggaa caactccaac attctggacc aaatttaaag caacctttat 131340
taaatattag atattgacca agggatggac cttagttggg accatttcac agaacttccc 131400
acctgagaat ggcctgagcc atgggttgca ggggcaaagg gcaaacctat aggccactgt 131460
actttcccat gatgctttgc tgtttcctaa gaactataat tcccagcatt gcaggaagtt 131520
actgggtttc tgggcaggta aggcttacag gttaattttg ggcattataa gacaaatacc 131580
aaaatattat ctatgatact attgctttat tttattttat tttcaattac atatgcttgt 131640
atgtgcatga gagtgcaagt gcccacagag gttagaagga ggtattaggt atcctggaga 131700
tggagttaca ggagattatg agctatcata tagatgttgg aattaaacct cagtcctctg 131760
gaagagcagc caatgagcca tatctccagc cctatcaacc tgttgggttg tttaaaaata 131820
attcttttat ttttattttt aagtatgtgt gtgtttgtgt gtgtgtgtgt acatgggtgc 131880
agtaccctaa gagaccggaa gagaacattg gattcccccc ccccccaccg cccccacctc 131940
ccgagctgga gttacaggca gatgtgtccc ttggaaacca aactcagctc gcctagaaga 132000
ggactggact atcgagccta agcgcccatc taagtctttg tatccagtct ttctgcaacc 132060
ctggaagcct ttttaccaaa aagtacattc tttcatccta gctgtttttt gtgactagca 132120
cctgctgaaa aaaaaaaata agaaagaaag aaagaaagaa aaaacccaaa acatcatcaa 132180
aacaacaaaa agccaagccc accaacaaga aacggatata cacaaaagcc aagaaaaaca 132240
aaacaagccc ccccaagccc cagctattca tcaagatagg aaagagaaac acccaactcc 132300
tacctgcgct tggtgattgc ttggtgaaaa ataaaagtat ttttcctctc attccttctt 132360
ttgtgatcaa atgaataatg aagggattga gcctttgcta gtgtgcatgc ccctgcaggg 132420
agccaagaaa caaataggtt tcctaagggt ataacccagc cttttcggct tttccgtcat 132480
cacgtgattg agggcttctg cttcccactt aacctgcatc cttcccagac tgattcatgg 132540
aacctcaagg gctctacagg aaaattcaaa catcagcttc tctctgccat aggacttcca 132600
tccgaaggaa tggttccttg gttgttgcct tcacagccct cacatccggg ctggacctgg 132660
cagaaagttg acatttgacc cctatctaga gcatagacga tgctggcagc cgtatgtcct 132720
cacttttgcc attccggtgc ctccctcggg gcacagccaa ggttccgaga tgggcatttt 132780
caggaggaaa cgattttatt tgaggtcttg gcagggagat gagaggagga ggcgtgccac 132840
cttctgtaac aaaaggcatt tcccagcctt agacacaccc ttaggcccag atgtacactc 132900
ccactcctgt caatccaact gcactgacta gcaaccctaa tgcctgctgc ttccaggcac 132960
cccgcagcct gcgtcttgtt tccactattt cctctgcctg tcgcagggaa agcctcacta 133020
ccaagagcct tcaaacacag ttcctgttac taattttgcc ccaaagggta ccacagtgat 133080
taacttaatg cttccccagg gatgactctc tctgtctggg gtcagggtgg ggctggatgg 133140
attttcttta ttaaggatgg tgggaaccct cttttgagct ttgaagtctc gccttagatt 133200
tttttttaat tttatttttt atttttgata actacaaagg gacaggaagt ctctttttac 133260
tcctctgagg cttgctgttc tccaggggca tggaaaatgt acacgttgtt agccccccaa 133320
gcctgggggc tggggcccgc gctctgccgg attgttttta tatcccagca aaaagcatct 133380
gtgtgcagaa cagcagctgg tctgctgctg ccaactgcac gttcccagta ccaatgtaag 133440
cactttcctt agaggttaaa acccccaagg cactgtttgt gtttggagaa gaaatgctct 133500
aaaaatagta agtgggggtt taaagtctct tcgtcagatg ttcggaagca cgctgacctg 133560
gtgcgctgct tcttagaacc agagctcatt ggcaggttgc tgtgccttgc acctacgatt 133620
cctgactcct tcagtaagct agctggtgaa gagctggaga atctgtattt ataataaatc 133680
cccgggtggg gcattgatgt tgctgatttt aagaacacac actgttgtag ccagtcaaaa 133740
gacccttact cagaaagacc acagagaccg ccgccatcgc tgcaaaccgc atgaggattt 133800
ttattgatcc aacatgttgg ggacacccct ctcagcacgc aggccagagg agagacccag 133860
aacaaagaaa gatcacattt tttatacctt tgtaaggggc agatttgagt aacagggttc 133920
ttattggtgt agcaagtaac cctttcaggc attggttggt ttgtatagtg actaagtaac 133980
cctatggccc agtgactact ttgcttgccc ccatggtggg ttattatgat ttggtcagca 134040
aagtaatagt actttaacat cacagctatt aacgtcaagg gaattctcac aacaagctca 134100
gggtggtttg tggtctttgt cagaattcag tgtggggcag gggtcaggag aattgctaat 134160
cttgttatgg ttacttctct gagaacagct agtattgttt tggtagttgc aagcttaatc 134220
attttgacca ccaaaactat gtttttacat ttgtttagtc agccggcttc cctatctggc 134280
tctgcacgtg gcctgcaagt acagtttgga aagtgttttt cgaaggagga aggtactggg 134340
tggtcttgaa ttcattttgg atattacaac acaaagaacc actggtctgg tgtatttccc 134400
cccagtctgt tgttggctgc agggtgtaat acagacacag ggtttattac cagggagagg 134460
agggtaccat agcttgatgc aattccttat tacctgtgtc gccaagagca agtagcttaa 134520
ccttgctggt ctctgtttcc tcccttcctt gacaatcatt tctatagagc taatttatat 134580
caggatctta attatcttgt tttgtggagg gcacatgttt ataaaacgtt gatctttctc 134640
cctaccaata ttttttctca ttgtcattta aagagtcagt tttgggactg acaagatggc 134700
ttagtgggta gagaaggctt gccaccaacc ctgatggtgg gagctcaatc tttgggactc 134760
acaaggaaga aggagaaaac agactctgat ctgtacacat ttaaattggc acgtgagccc 134820
ttctcctcaa ataaagtcac acacacacac acacacacac acacacacac acagagagag 134880
agagagagag agagagagag agagagagag agagagagag agagagagaa agatacacac 134940
acacatccca tacacatttt ttggccaggt tagacaatgc tggggaaaga tatcagattt 135000
atgcatctct ctctctctgg actgagttgg tgactgtggg aagggatggg acttgactac 135060
tgcaacttgt cagagcacag taggccactg tgaattgcag ctctcagact cctggtacca 135120
tcccatagtc cagcacatgg gagctaaaag tccaaataac aacaatgctg tctgaggact 135180
tggaggcagg tgacattgtg gtagggattt gtggatttcg atgtgtgttt gttctctgtt 135240
tttaacacct tccatcagat aagttcctgt cctgtttctt cagatcccaa cctgttttcc 135300
atttccttgg ggagcctttg aaatatgtgg ctggatctgg atgttatgaa cttgtatgga 135360
gttctgcaca agtctttata gtttcatttg attgcaatcc aattaatgta aggatcctcc 135420
ctgaatgatg cgccctgtga aagcaaactc catgcttaat ctcttcccta tacttgtgta 135480
gtatgcattt cttgactttt catgagacat tcagagacta tcctataaaa gtgtgtaagt 135540
cataaaagtg tgagattaaa aaaaatagca ggtgcaaatg aatcacattt tcttgatcca 135600
ttctttggga aacatctggg ttgtttccag tttcttgcta ttacaaatat agctgctatg 135660
tacctggtag aacaagtatc cctgtggtat ggtggagcat cttttgggta cacgcccagg 135720
agcggtatag ctgggtcttg aggtagaact attcccaatt ttttgagaaa tcaccaagct 135780
gatttccaga gtcgttgtac tgttgtggcc ggccagcagc tcgcaacgtg aacgtgactg 135840
agatggccac tcgagctaag ggaggaacta gtcggggaga aagaagaaac ggagccaaga 135900
caagttcatc ctgttcaaag ctcaatttta ctagttctga cattcagtta taaaggaagg 135960
gggagggaac ccgattcccg ccaactggtc ttggagtcca gtagcagggt gaacacgtgt 136020
gtggctccaa gcagcaaagc agcacggtcc agcagtgggc gtggcagaat gaatgagcgg 136080
gaaactccac ccctgagcca gcaggttcca ggctgggggt ggggaggctg cagttgtaca 136140
agtttgcacc tgcaatggag gaatgttctc ttcgctccac atcctcacca gcatttgcta 136200
actcttgagt ttttgatctt agccattctg atagatgtaa ggtggaatct cagagtcatt 136260
ttatttgtat tttccagatg attaaggaca ttgaacattt ctttaaatgt tcctctgaca 136320
ttaaagattc ttctgttgag aattctctgt ttagctctgt actctatttt ttaagattgg 136380
attatttgtt ttcttggtgt ttaagttctt gagttcttta tttatcagtc ctctgtcaga 136440
tgtagggttg ttgaaggtct tttcccatca tgtaggctgc ctttttctcc tattaattat 136500
gtcccttgca ttatagaagg ttttcagtgt catgaggtcc aatttattaa ctgttgatct 136560
tagcgcctga accatttgtg ttctgttcag aaagttctct tctgtatcag tgcattcaag 136620
gctatcccca ctttctcttc tattagtttt agagtatcca gttttatgct gaggtctttg 136680
atccacttgc acttgagttt tgtgcaggat gataagtatg gatctatttg caatcttcct 136740
catgcagaca tccagtagga ccagcacaat ttgttgaaga tgctttcttt tttccattgt 136800
atggatttgg cttctttgtc aaaaatcaag tgtctataca tgtgtgagtt tatttctctg 136860
tcttcgattc aattacattg ctcagttatt aaaagcaagg acatcatgaa gttttcaggc 136920
aaatggatgg aactagaaaa tatcatcctg aatgaggtaa cccagctcca aaattataag 136980
tagatattag ccataagtat acatacagga tacccaagct ataaaccaga aacccaatta 137040
tgctaaataa caaggagggc tcaagggagg atgcttaatc tcactgagaa agtgtcctag 137100
tcagggtttc tattcttgca caaaacatca tgaccaagaa acaagttggg gatgaaaggg 137160
ctttttcaag ctacacctcc acattgttgt tcatcaccaa aggaagtcag gactggaact 137220
cacacagggc agaaacatgg aggcaggagc tgatatagat gccatgaagg ggtgctgctt 137280
actggattgc tcccctagct tgctcatctt cccttcttat agaagtcagg accaccagcc 137340
cagggatggc atcacccaca atgagccctc ctcgcttgat cactaattga gaagatgcct 137400
tacagctggg tctcatggag gtatttcttc ctcaagggag gctcctttct ctgtgataac 137460
ttcagcttgt gtcaagttgg cacataaaac cagccagtaa aggaggagaa acaaaatagt 137520
cattggaggg gatggaggga aggaactggt tgagagaggg gctggggagg gaaatgggga 137580
gttggtcatc aggtgtaggg agagaagggg aaagggggct gtgagagtga atggaaattt 137640
gtggcaggtg ggagtggggt gggggtgggg aggctgccat atcatttcta ggatgtgtca 137700
gagacctggg acaggggagg ctccaggtag actatgaggg gcctctagct gagattcctt 137760
gtaatggggg atatggagtc tgaaatggtc acttcctgtg gccagacagg acctcccagt 137820
agagggaaaa ggataccaac ccacccacaa aacctttgac cctaaatttg tcctgcctac 137880
aagaagttcc gggacaaaga tggaacagag acaaagggaa cgaccaacca atgaccagcc 137940
caacttgaga cccgtgccgt gggcaggaac taatccttaa gatttaatga tactcttgtt 138000
atgcttgcag acaagagcct ggcatatctg tcctctgaga ggctccacct agcagctgac 138060
tgaaacagat gcagagactc atagccaaac attagacgga acttggaaaa tgtggaagag 138120
ttgagggaaa gattgaggga cacagagagg ataggaactc cacacgaaca acagagtcaa 138180
ctaacctgga ctcttgagag cttccagaga ctgaaccacc aaccgagcat gggctggacc 138240
ttggcatcct gcatttatgt agcagatatg caccttggtc ttcatgagag tccctcaaca 138300
actagagcag ggactgtcct tgaccctgtt aactgcctgc ctgtggatcc tattccaact 138360
gggctgtctt gtctggcctc agtggaagag gatgtgccta gtcctgcaat gatttgatgt 138420
gccagggtgg gttggtaccc agcacccccc tcaaaggaga agaggatgag ggaggagcta 138480
tgtgatgggg gtactgggaa gagaggagag atgcaaattg gaagtaaagt gaataaataa 138540
ataaattaat taatggaaaa aagtagtggg tgctatgaag gagtcatcta tattagattt 138600
tctggagtta taacaaaata cttgagagaa atggagttat tttattatcg ttttggagat 138660
aaaagtccaa ataacagtag tattatctgt ggtaagaact actgtagatg gcactgtgat 138720
aagaatttgt cagttcctat gtctgtaaat gtgtagcgtg tgtgtgtgtg tgtgtgtgtg 138780
tgtgtgtgtg tctgcatgtg catgtatgtg gggtgtctat gtttgagatg gatatggatg 138840
tgctgtgtgt tatatgtatg tgtgatatat gtgctgtgta tgtggaagtt atgtgtgggt 138900
atgggtgggg gctatgtgtg aaagaaagag agaaacagga tagggaaagg aagtcagagc 138960
cagacctata tggggacagt aatgacctcc ttatttagat ttatctctta agggttaaag 139020
atgacattat tttttaacat tgttgctcca ggaccaggct cctaatgcat gcagtctgag 139080
agacacattc aaatcatatc ctatacacag taccatcctt tggccagaat attggtaaaa 139140
ccatccaaat gttagaggag agtagccaac agttctggca tccgtataca gcactgccgg 139200
cgtagagtgc cctactgccc tgaagatgcc ctgtgatttc attgaaaatt ctttccagat 139260
tggtaacctc tcagcccggc tctctgtgcc ttatagatca tgagatctgt aacatacaac 139320
gtaacaatta gcttctcagt tcttgttgga gaggctgggt ttataagaaa gaaagcagcc 139380
aagcacatca gcccacggga gcctggcata aagtgtacct cagcagttcc ttagtgtttg 139440
tagaataaag taatgtatta tagctttcct atagatccac atggaagcct gagaagctat 139500
gtggttctcc tcagacctca tagtctgctc agattcactc acttgggcgg gttgtatagc 139560
tctggggaag atttcacttc tctgcctcag caacacaggc tcaggcgcat cctgctttgg 139620
gttgtgaagt tgaccggaag tgacacgtat agctttcaga aagaagtttg aagagccagc 139680
atgtgactga ccattcgtgc ccttatacct tgttttttcc aaggattatg atagagccac 139740
aggccattgg gtgctgatat ttgttttcat ggtgtaacta aatctgtccg cagagcaaca 139800
cttctttttt atgaagataa gaagtaactg aggcaggttt ccaatctaga catggttact 139860
gtagggtctg ctacttgcta gcttcaccca gctgaatcaa gaagagaaaa caactggcca 139920
agcttgttgg gggcatacat gaaagtctag tacttaggag gtggaggcag gaagataagg 139980
agtggaaggt cagtcttggg tgcatttgtg tgtgtgtgtg tgtgtgtgtg tgtgagagag 140040
agagagagag agagagagag acagagacag agacagagac agagacacag agagagacag 140100
agagagacac agagagagag agacagagag acacagagag agagagacag agagagagac 140160
acacacacac acacacagag agagagagag agagagagag agagagagag agagagagag 140220
atattccctg gaatcaggct cccattacaa gcactaacaa ttccatctga tgccttgcaa 140280
attgtttcag aggcctggga aagataggaa aattttctgc ctatttttag aaagccaatg 140340
taacattgta ccaaaatctt ataaagatag cattgaaaaa aaagaaaacc aacatccgat 140400
ctcattgaag gagtaacaaa tcctaaatta ttaaaataat aacagttcag caaagcatta 140460
aaatatacca agtgaagtcc ccttttgaca atcaacaacg gcaccttacc ccacacacat 140520
tatgactgac tgtgtacccc tctaaaatag gacgaagggg gaaagaatgc attgcttcag 140580
aaaatgaccc agcaacatat gctagttatc tatttatttt tcttgccttg acagaagcta 140640
gctagtatta tctggaagca gggaacaatg tctgttgaga acctgcctct gtccggattg 140700
aactgtcaca aggcaagtct gtgaaggcat tttcttggtt taataattga tgtggtaggt 140760
ccagccctct gtaggtggta ccacactgag tgtgtggtcc tgggtcgcag ggttaaggaa 140820
cctgaacatg agcctggaga ggaagccagg aagcagcact ccttcatggc ctctgctcca 140880
cttcctgctt tgagtttcta gcttgaattc tcttcatgaa aaattattgg ctgggctggc 140940
gagatggctc agtgggtgag aacactgact gctcttccaa aggtcctgag ttcaaatccc 141000
agcaaccaca tggcggctca caatcatatg taatgagatt ggacacgctc ttctggtgtg 141060
tctgaagaca gcagcagcat acttatttat actaataaat aagtctttgg gccggagcga 141120
gcagaggtcc taaattcaat tctcaacacc agatgaaggc ttacaactaa ctatctgtac 141180
agctacagtg tgtaatcata tacataaaat aaataaataa atcttttaaa aattgaaaaa 141240
ttatttggtg taaggtaaag aaacaaaaac ccaaacaccc tttccttttc aagtcgcttt 141300
tagtcgtggt gtttatcaca ggagctggag gccatgtaag atgcgtagga tgtagcattt 141360
agaagccatg taggacacct cgtttagtgg agctaagcca ctagtgtgat ataagagtcc 141420
gacgttaata gacggcttta ccaaggaata atgaattctg tatttcaaac ggagtcggga 141480
ttggcttagg gttaaaaaga acctagaagt caaggttccc caggctgggg tggctctgat 141540
agacgagtgc caagcacagc tgcagatagc gcaaaagtat gacttaaaag atacatgcta 141600
taaggaagaa aagtgaggga aaattgcaaa atatgaaaat agcaagaaat ttcatgtatg 141660
tatcaagttt cccaaacaag ggacaggcac acagtcacac agacacatag acacatagac 141720
acacaggcac acagacacac agacaggata ggatattaag cactgcattt tgttcctctt 141780
gttgaaaccc tatgtagttt cattatgtaa tccaggctgt cctccgactc atgctactcc 141840
ggactcagtt tcccaagtgc tggggtttca ggcacactgc taccttgtcc cactgaaaga 141900
gttgtgcctg agatggtcat tacttagtga aggacagtga gacttcagca atggagatgg 141960
catccttgtt agtggatttg tccacttaaa tgcattagac aaagtctggc ttatcattta 142020
ttattattgt tattattatt attattatta ttattattat tattattatt ttaagcatag 142080
agttagtgat tactcattcc tatactttcc tattgttaag gaaaaaaatc taaaatggca 142140
aaatcacaat gtgaaataca tatgcaaaga tcttaaaacc accagtccgt gagtaaacca 142200
gttccttttg gagacaaagg aataggcagt aaataagaga aaaccacatt tgttaatgga 142260
tgggtagttg ttcactctag ccatggagac actgaatcag cactcgacac gattccttta 142320
catacttaca gaggacattg attcgtttct attgttactg agtagctcca acttcccagg 142380
tcacaagttg ccaagagcag ccaattattc ttaagtttca atttgttgaa aaaaaaaaaa 142440
gccctgatag cattgatgtt catccccgag caactcagta actcagtgtg tgtgtgtgtg 142500
tgtggggggg ggtgtgtgtg tgtgggaggg tatgtctgtc tgtgtgtctg tgtgcatatg 142560
tggacataca tatgccatgt cacatatgtg gaaatcagag gacaacctgc aggagttagt 142620
tctgttcttg aaccatgtgg ggttctggga attcgagtca agccattagg tttggtgtca 142680
agagcttttt cccgttgagc cattttagcc catagaaact ggttctacca caaacattta 142740
caagatacaa aagctaagga cactgcttag tccatttaaa atgatatagg tcccaaagct 142800
tcgcttactg tgggattttc tcctatcatc tcatcccttt ctttcatctg gtctttagga 142860
tccttttctg aaggtgtgaa gttggtagag aagcctactg tgtggacagg aatgtctctc 142920
aaatgcatca ccattttgag tagtagtgat tgagaacaaa gggaattgtt gtaaggtgtg 142980
gagttatttg ataaggtgtg gttgtaacaa agcaccaaaa ctgggccagg gagatagctt 143040
atcaggaaaa gcacttggta cagcctcctg aatgccagag ttggatccct ggagtccaca 143100
gaaaaagccg agtgtggaaa gccagatgca gtgacaggaa tttgtaactt gggcattcct 143160
gggaagagat gaaaggagaa gatgggagaa tggcctgaag cttaagggac agctatggga 143220
tgtgtgctac aagaacagaa actagggaga ctctgcctca aagtggggtg ggaaccaact 143280
acacacaggt atgttcaagc agacaccaca cacacacaca cacacacaca cacacacaca 143340
cacacacaca cacacacaca cacacattat taaagctgat aacagctttt agactaagta 143400
gaaggaaaaa gagataactg tagttaacaa aatctaattc ccaatttgct acctacattc 143460
cctacctgca gtatgctaac tttaagaggg aaaaagtcct ccaaccagag tgtatataaa 143520
atatgttgtc tgatcctccc aatagtggtt ttctaaaagg aatatcatag aagatattta 143580
gaagacttcc ttttacgtta ctttttgaga cagggtttta tgtaagccaa gttgacctca 143640
aactttgaat cccacttctc tacttcctga gagctacagc tataaatatg caccatcatg 143700
gctggtttac atggtgctgg ggacagaacc caggactttg tgatgctagg caagttctct 143760
accaactgag gtcgatcccc agccctcaga taacattgtg tggcgctatt ctgtctaccc 143820
aagagagttt atagtttaga cttccagatc aagcgaaata aagagttctg gggagatgtc 143880
cttttgcttc ctagtgtagg tatagatgtt acgggatggc aggatttagt cagaggaaga 143940
gactcaactt ctctgaaggt cttactatgc atacaacttt ctgctatggt tcttatcctg 144000
tggcataagg acatcccctg ccacccaatt ttacatgcca catcccaaat cattgtaacg 144060
aggcttcaca tggcaaccag cagttgactg caatgagact tccatggcaa ccagcagttg 144120
actgtaacaa ggcttccatg gcaaccagta gttgactgca acaaggcttc catggcaacc 144180
agcagttgac acctgccttg ctctggtttt gttacagctg aactgtttct catctgtgaa 144240
accccttttt aaaacatgta ttcatttatc ttatatgtgt acactgtagt tatcttcaga 144300
cacaccagaa gaggacatca gatcccatta cagatggctg tgagccacca tgtggttgct 144360
gggaattgaa ctcagaacct ctggaagagc agccagtgct cttaactgtt gagtcatctc 144420
tctggcaccc ccgctcccat gaaacccttt tgcatatatc tttttgtctt ctagtcttgt 144480
ggtccacaag ccctacaagt cacttttgga gttcttcctt agccccactc ccacattctt 144540
gctttggatt atcttcgaca ttcagtgctc tcagggcagc tgtgaacctc cttgaaaaat 144600
tttctctctt gtctggtctc taatgatgtg tagacttgac ttactagggg ttcatgtctt 144660
gctctctctt tcatgcagtt caattcatat ttagcatcct aagtcagtga ctatagggaa 144720
aggttttgag cccccttgga agtctctgct gcaagcatag atcttgcaga gtagatattt 144780
aatgaactct tattaaatcc atgcatgaat gaaactcttc atgtgtattt cccaatcttc 144840
tctctacatc attgaaaggg gaataacaga atttaaattc ttcacaattc ctgcaaaggg 144900
agacttctac taagtatgaa atgtgcaagg cttgaatttg taatgaatgt ctgatgtaac 144960
ccagcattcc cagaatcacc acttgggttt tccacaaggg tatgcattcc tcttttatac 145020
aaatgcatgg agggggaggg gttacaggat aggcagaaat gaaagatatt tgttaatttt 145080
ctgttattgt gataaaacac tatgatcaag gaaactaatc gaagaaaaaa gtttatgtgg 145140
ggttatggtg gccgaggatt agagtccata gcttgcaatg gaggttgcag gtaaccagaa 145200
cagaacaggc tcacatccct gtcttcaagc aggaaacaga aagcatgcgg agtggtgtaa 145260
ggcattaaac ctcaaaggcc atcccacagg tcacacttcc tatacctccc caaacagtgc 145320
caccaattgg gaaccaaaca tcagagtctg tggaggacat attcgttcaa accaccacca 145380
cagacaagta gtttattctg tgcacccttc ttatggagga ggctgacaag taccactgtt 145440
tacacacagt aggactgcca cgaacaatat agccatactc actacctgct ttcccggttt 145500
gtggccttcc catacctcac agaactttct tcttcctgcc tgtacatttc actgctgtct 145560
cttgctgtgg agtggggctc tatatgtgcg agggtctcag tgtgaagcag gctctgtgct 145620
acttgtctta tcctgagtta cagagattat tttttgtccc agtccctatc aggagtcact 145680
attttgagcc caatctggta gctctggttt cttctttcca gaatattctg agtcgcgcag 145740
cctcaaaccg gctctgcctt tcctctacat gcctgtgatg acgactgcct ggctgcagat 145800
gctccgggtg ttttcccaca ccagtttctc ttgttgtgac tccatcaaac ccaggtcagc 145860
ttctgtaatc gagacgatcc acttaattaa ctgtaatgag gctcccatca tttccaataa 145920
atttctttcc aaaacaccac ttgagaggca catagcttcc tatcagctgt aaattttttt 145980
tttcctgtct atttagttcc aggaattgaa tttactcaga gatgtcattg cccaacctca 146040
tgtctcaatg ttttaaacta aatctttcag tctggtgcta tgggctacag gacccaaccc 146100
cagtttccct tgtacagaat ggaagatgcc gtgcaaacag cttgtctggg tttcaccaga 146160
gctgggagaa tcagtgctgg ttttcatggc ctcttctgcg atcagcccct tctccaccaa 146220
cagttttgtt agttagacag agcaacttgc gcttgaagat ctcaaaccat ttatcgaagc 146280
atgccatctt ctccttttta aagacctgaa atgctgttgg aataattttg ctgtgtttta 146340
taaaaatata gagaggatta atacgtttgg tagaggtgca ataaggtgtg gagggaaggg 146400
gtgcctccaa aggcctgtgc tgaggcacct cttccccctg agcgaccagc caaagaatgg 146460
tatagtatag aatagagttt attcatggca tggggagggg agttgagaga gtagtagaga 146520
cagagaaaga gagagggaga gagagaaaga gagagagagg ggggggaggg agggaggaag 146580
ggagagagag agagagagag agagggaggg agagagagag agaagagtag tagaggctgg 146640
tcatgagcat gtggagagag agggggaggg gaatggggaa tgggggagca ggagggagag 146700
gacagagtcg gagcaagaaa gcaagagaga acagaggggc taagcagtcc cccttttttc 146760
attttaaaaa ttttattaga tattttcttt ttttacattt caaatgcttc ctataccctc 146820
ccctcgccct gctcccctac ccacccatag cagccccttt tatagtgagt caggcacacc 146880
tggctgttgc caggtaactg gggcagagcc tatacaaaaa tgctaacaga tttgtcagtg 146940
aaatgatatt ttgctctttg acttatagaa gatgaaaaag aaaaccacaa gtttcatact 147000
gaccctttgg ggaggataca tctttaagaa attatgggag agaatagttt catttagaaa 147060
gaatttaagt gttttttttt cccctctcag acatgtcatg gtttaatatc agttatccaa 147120
tttttctttg tgctactctc agaattcttc ctgagaaatt agctttaatc ttctgctttg 147180
tttcaaagcc tgcactagat taagcctcgt cctctctctc tctcctctct ctttctcttt 147240
ggcttcattc gggaatgact aattagccag gagaaattaa atttacaaat taaacctctc 147300
tgcatagatt ttctcaagac cccagccctg ggggtaatat ccatggcctc tcctacagag 147360
cttttgcctc ccagagggtt gtatagaggg gtgaaatgtt tatgaagcca catcggcttg 147420
aagagcaggt tggtggttgg cggttggcag cattataagt tgttctttgg ttccttcagg 147480
gaaaaacttc agtgttccaa agttcagggt catggaagga gggtgaggaa tgttcccagc 147540
cagagaagaa agtgatgtgt gtgagagaga actgccgaga actgtagaac tgaagtttcc 147600
accgctccaa ttacatgcct gaatgccttc ttttcatttc atctctgttt attatctttg 147660
tctgtgtgtg gatggtgtat atatggtatg tgcatttatg tgtgtgagtg tacacttatg 147720
catataaatt caagtgctca tgttttactc cacgtataaa gagatcagag gacagccttg 147780
ggtattgttc attgcctttc acctttctct ttctctctct tgaatacacc acctatcatt 147840
gtaggagact ggcatcacag acctgccatg gctggctttg tatgggatgc agggatgtga 147900
atccaggtcc tgatgtctat gtggcataga cacttaacta ggaccccaac ccattcacct 147960
cccaagcctg actctgctcc cctgctccac tctacaacat gccctctact cgataaaggc 148020
actaaaatgt gtgactaggg gccatccagt ttgttctgag tgtcagctca tgcctccttc 148080
ttaggaagca tttcaagcca atgtctctta ataccaccca cggttcattg ttttctggct 148140
tctccttcct tccttccttc cttccttcct tccttccttc cttccttcct tccttccttc 148200
ctcccttcct cccttcctcc cttcctccct tcctcccttc ctcccttcct ccctttctcc 148260
cttccttgct ttttctttct aacatctttt gtgtattgaa aatgctgatg tttttgctat 148320
ttggggatga gctcttgcag gatagtgttc cccaactctt ctcttccaag tttattctcc 148380
agatctttgc attaagttag gcaggctcct ttagggacag agaccgacgg cttactggag 148440
gggaaggctt cagtcccatt aaaagatggt taatgaacat tcaaagttag tgtttctctt 148500
tgtttcagct gcagatcttt tggagaatct taggagaaag cagccaagac cactgaatcc 148560
acctgacctc attaacctgg agcaaactgg gcttattaga atttagattg aaggcctcag 148620
aggttagata ttgctcttgg agaagaccta ggttcagttc ctagcaccca cataggtcgg 148680
attacaattg ctgataactc cagttccagg ggatctgtca ctttcttctg accttccagg 148740
tcttcatgca cattgtgcac atacagacaa gcacacgcac acacacacac acacacacac 148800
acacacacac acacacacac aaatattaaa actctggagt gtgaacttag tatgcccata 148860
ggtaattatg tccattagct ttcctcattg gacattttct ctgtcacctt taactcagga 148920
tgctcacaaa tatccctacc cctctacgta cttcctttat gaatttgtat atgccccttc 148980
ccttgtttgg ggagcagatg tttctctact ctttgatctg actgttgtgc tcactggttt 149040
catactcacc aagagacctg attcgactta ggtaccgagt cacccacgtc tctcagggtc 149100
agcctgctct gtctctcagt ttttggtcta agaaaacaag gccttccacc cttttgatca 149160
gcagatatga gtaaaagaaa taaaagttga tgctctttgt tttccaggga ttcagataaa 149220
atgtttgcca tatgcatgaa ataattttta agaggtaggt tggttcttcc ccctaaagca 149280
aggtttatct aagaagagtg cttttaagga tggtcgtgat gctgacagta cctcgcattc 149340
ctaccgtcat ttctggaaaa gccattttaa tttttcatct cacctcgcca tctgggagac 149400
aagtgaactc aatgttttcc ttgccattta taaagtgagt tagttaagac tcgggtaaga 149460
ctattgatct gcaccaagat ccaataccag gaaaagagat gaaattggta tccaaacttt 149520
tgtttcagga ctctgagccc tggcctctat tgtctcaaac acagttcaat cataaactga 149580
gtcaatacat ctagcactgc ctggcagtat aaggcaatta aactatcaca aggctatggg 149640
ggtaaagaca ctatcacaaa ggtctgggat aaataaactt gaacaggttg ataaagtgtg 149700
ggactcaatc tctaaaggag gtgctgtaat ctctctgtag tggaaggttt acctgaagga 149760
acagatttga agttattcct gaaagcatac taaaaccaga agacagtttg gcagtccgaa 149820
tcaaaaactt taactaaaga catgaaccac agtactttcc agcatatcac tcagtggctc 149880
taaagttctt ttccttgttt gaaaacaata gagtccaggg gaggattaaa tggtgatttg 149940
taaagtgcca ggctcagggc acattcagta aatgttacca gtgattgcag aataatggtg 150000
ataatatttt cctttgtagg aggaaataat gagcacgtag atttagcaac acacagatcg 150060
tttgttgtgc ttttaaaagt cacagtgaaa agttggaaac aacttgatgt ccagcaagag 150120
ggaattgcag aagagagttt cctggtattt ctaggtgcta gatcattaga tagccatgta 150180
aaagaataaa aggaaataaa tatgttattg cctagcaaga tggccatgaa tttgttgttg 150240
ttgttgttat taagacaggg tttctctctg tagccctggc tgacctagat ctatagacca 150300
ggctggcctc aaactcaaag atcgatctgc atctgcctcc tgagtgctgg ggttaaaggc 150360
ttccaccact gctgcctggc tataaatgtt taaaatatat tttctattaa ttcttcacaa 150420
attccatata tgtgtacagt gtattttgac catattcacc cctactcctc ttcccaaccc 150480
ctttcagctc ccctgctgcc atatttccat cccttaccaa ttttgtgtac tatttaatta 150540
atagatatat acatatatat atttaattct gatatatcag cacattatat attatattat 150600
attatatgtt acatatatta tctgttacat aatatacatg tatacatgta tgtatatata 150660
tatatatata tatatatata tatatatata tatatatata catattgatg tacacccatt 150720
cattggagtc tggatgcctt gccagggacc actcttaagc aaagtggcct ctccctgatc 150780
tggaagtccc ttgactgtta acagatcctt agctagggct ggagacttgg gagccccatg 150840
cctctctaag caggaatcct gacttggtct tgggctgcca ctgtgagctc atgaggcagt 150900
gttgggggag ggatgcttta taccatcccc tttgtgactg agaattccac aaatgctcat 150960
tctctgcact tggcagtgat tttttacctt tcaaaaacac ttataaaata ttaaatcctt 151020
tttttttaag tttgtgcttt tttgatgttg tttaacacat atattcatgt acagatacag 151080
gatagcttta aaaactagga gatgaatttg cagctctatg tcaacaaaac tgacatttaa 151140
aaattgtttt tattaaaatt ctttttattt aaactatccc agtaacaaag gcaagtatca 151200
tgtaaaataa aattgtgctg ttttgttttg tttctggctt tcttgtttcc tactctttcc 151260
tttggtttgt cagctctgtg ctaccataag cagacacgat ccattcaata gttgactaac 151320
agcattcttt tgagtgttta ctgtggccaa ggccctggtt ctaagcactt gatgtacaga 151380
taaaccagat gaacaacaat gcccttcaaa agcttaaatt caaggctgga gaaatggctc 151440
agtggttaag agcactgtct gctcttccag aggacccagg tttgactccc agctcccaca 151500
tggcagctta taaccatcta cagctccagt cctgggaggt ctgacactct ggtacccacg 151560
tggtacatat aaatatatgc aagcgagaca tgtgcacata taattgaaat ataggtatag 151620
tgatcttggg attccagtgt ctgaagcagg agaaggatga gactgagatc agcctggaat 151680
aagatcctct tttgattaaa acaaaagcat gtactaggtg acatgaacag cacaaccgca 151740
agagaaggag agtagaccaa aatttctaga ggagctatgc cttcttaaca gcattcaacc 151800
cctcttctga gaatccctgc agactgccct ccagcatcac tgatttccat agaggctgca 151860
tagctgtcaa agttcacagt ctactcagag gtaacctgct gtgtcaatat ttgtaatttg 151920
tacttcatgg tgagtcactt ccagagaata gattatctac catggaaggg aaaaggtctg 151980
ggagtgaaag tgagctggac aagacacagg tggaggcatt aggtttcaac agcttcctgc 152040
ctctacaaag caaagggcag gaatgtgtgc tggcgtgggc tggagcccag aacagccaca 152100
actctcaagt ggaggataag cagaaagcag ggttagtctc ctgtttctcc aggtggttct 152160
agctgattct tctaggtctg gaaacaaatg ttaccttcta tccattttct ctccttctcc 152220
cctggcttcc atttttatag ctcagaagca aatccatctt ttaagagttg ttctcaagca 152280
atctttgtct aaagctggat cctcaccata ctacatccca cttcaccccc acctccaccc 152340
tcactgccaa ttgaggaagt tctctgaatt ctgacacctc catagcatgt gatagtcccc 152400
tatgttattc ctatgcatca attcattttt acattgtgct ggagaactcc atctctctta 152460
caagagtaga tgatcattaa ggtttggtct atagaactcc aaatagactg gactagaaaa 152520
gaaattcctt ctgacacata ataatcagaa caacaaatgc actaaataaa gacagaatat 152580
tgaaagcagt aagggaaaaa ggtcaagtaa catataaagg caggcctatt agaattacac 152640
cagacttctc accagagact atgaaagcca gaagatcctg gacagatgtt atgcagaccc 152700
taagagaacc caggccaggc tactataccc agccaaactc tcaattacca tagatggaga 152760
aaccaaagta ttccatgata aagccaaatt cacacaatat ctttccacaa atcgagccct 152820
tcaaaggata ataaagggaa aacaccaaca caaggacaga aactacaccc tagaaaaagc 152880
aagaaaataa tctttcaaca aacctaaaag aagactgcag caagaacaga atccaaactt 152940
taacaacaaa attaacagga agcaacaatt acttttcttt gatttctctt aacaccagtg 153000
gactcaattg cccaatgaaa agacatagac taatagactg gctacacaaa caggacccaa 153060
cattttgctg cttacaggaa acccacctca gggaaaaaga cagacactac ctcagagtga 153120
aaggctggaa aacaattttc caagcaaatg gtctgaagaa acaagctgga gtagccattc 153180
taatatcgaa taaaatcgac ttccaaccca aagttatcaa aaaagacaag gaggggcact 153240
tcatactcat caaatataaa atctactaag gtaaattctc aattcttaat atctatgctc 153300
caaatataag ggcagccaca ttcattaaag aaactttagt aaagctcaaa gcacacattg 153360
cacctcacac aataatagtg ggagacttca acacctcact ctcaccaatg gacagatcct 153420
ggaaacagaa actaaacaga gacacatgga cactaacaga agttataaaa caaatggatc 153480
taatagatat ctacagaaca tcttatccta aaaaaaagga tataccttct tctcagcacc 153540
tcatggtacc ttctccaaaa ttgaccatat aattggtcac aaaacaggcc tccatagata 153600
caaaaatatt gaaattatct catgcatcct acctgatcac cacggactaa ggctgatctt 153660
caataacagc ataaataata gaaagccaac attcacgtgg aaactgaaca agactctact 153720
caatgattcc ttggtcatag atgaaataaa gaaagaaatt aaaaactttt tagagtttaa 153780
tgaaaatgaa gccacaacat acccaaactt acgggacaca atgaaggcag tcctaagagg 153840
aaaactcata gccccaagtg cctccaaaaa gaaactagag agagcataca ctagcagcct 153900
gcagcacacc tagaagctct agaactaaag gaagcaaatt cacccaagag gagtagatgg 153960
caggaaataa tcaaactcag ggctgaaatc aaccaagtgg aaacaaaaag aactattcaa 154020
agaatcaacc aaaccagaag ctggttcttt aagaaaatca acaagataga taaaccctta 154080
gccagtctaa ctagagggca cttgtatcca gtctaactag agggacagta tcctacttaa 154140
caaaatcaaa aatgaaaaag gagacaacaa cagatcctga ggaaatccaa aacatcatca 154200
gatcctacca caaaagtcta tactcaacaa aactagaaaa cctggatgaa atggacatct 154260
tcctaggcag ataccaggta ccaaagttaa atcaggatta gattaacgat ctaaacagtc 154320
ccatttctcc taaagaaata gaagcagtca ttaataggct cccaaccaaa aaaaaaaaaa 154380
aaaaaaacca ggaccagatg ggtttagtgc agagttctat cagaccttca aagaagatct 154440
aattccaact ctcctcaaac tattccacaa aatagaaaca gaaggtactc taccaaattc 154500
attctatgaa gccacaatta ctcttatacc taaaccacac aaagatccaa caaagaaaga 154560
gagcttcaga ccaacttccc ttatgaatat ccatgcaaaa atactcaata aaatccttgc 154620
aaaccgaatc taagaacata tcacaatgat catccatcat gatcaagtag gcttcatccc 154680
agggatgcag ggatggctta atatacggaa atccatcaac ataatccact atataagcaa 154740
actcaaagac aaaaaccaca tgatcatctt gttagatgct gagaaagcat ttggcaaaat 154800
ccaacacccc ttcatgataa aagtcttaga aagatcagga atttgaggcc catacctaaa 154860
cataataaaa gcaatataca gcaaaccagt agccaacctc aaactaaatg gggagaaact 154920
caaagcaatc ccactaaaat cagggactag acaaggctgc ccactttctc cgtacttatt 154980
caatatagta cttgaagtcc tagccagagc aattagacaa caaaaggaga tcaaggggat 155040
acaatttgga aaggaagaag tcaaaataat cactatttgc agatgatatg atagtgtata 155100
tataagtgat cttataaatt ccaccagaga actcctaaac ctgataaaca ccttcagtgc 155160
agtagctgga tataaaatta actcaaacaa atcaatggcc tttctctaca caaaggataa 155220
aagggctgag aaagaaatta gggcaacaac acccatcaca ataggcacaa ataatataaa 155280
ataccttggt gtgactctaa ctaaggaagt gaaatatctg tatgataaga acttcaagtc 155340
tctgaagaaa taaattgaag aagatctgag aggatggaaa gatcttccat gcaggattaa 155400
ttggcaggat taatatagtc aaaatggcta ttctgccaaa agcaatctat agattcaatg 155460
caatccccat aaaaattcca acataattct tcacttagtt agaaagggca atttgcaaat 155520
tcatctggaa taataaaaaa cataggatag taaaatctat tctcaacaat aaaacaacct 155580
ctggtggaat caccatacct gaccttaagc tgtactacag agcaattgtg atgaaaactg 155640
cctggtactg gtacaatgac agataggtag atcaatggaa tagaattgaa ggcccagcaa 155700
tgaatccaca cagctgtggt cactggatct ttgacaaagg agctaaaacc atccagtgga 155760
aaaaaggcag cattttcaac aaatggtgct ggcacaattg gcggttacca tgtagaagaa 155820
tgggaattga tccattcttt tttttttttt ttttccattt tttattaggt atttaactca 155880
tttacatttc caatgctata ccaaaagtcc cccatatcca cccaccccca ctcccctgcc 155940
cacccactcc ccctttttgg ccctggtatt cccctgtact ggggcatata aagtttgcaa 156000
gtccaatggg cctctctttc cagtgatggc cgactaggcc atcttttgat atatatgcag 156060
ctagagtcaa gagctccggg gtactggtta gctcataatg ttgttccacc tatagggttg 156120
cagatccctt tagctccttg gctactttct ctagctcctc cattgggagc cctatgatcc 156180
atccattagc tgactgtgag catccacttc tgtgtttgct gggccccggc atagtctcac 156240
aagagacagc tacatctgcg tcctttcaat aaaatcttgc tagtgtatgc aatggtgtcg 156300
gcgtttggat gctgattatg gggtggatcc ctggctatgg cagtctctac atggtccatc 156360
ctttcatctc agctccaaac tccgtctctg taactccttc catgggtgtt ttgttcccaa 156420
atctaaggag gggcatagtg tccacacttc agtcttcatt ctccttgagt ttcatgtgtt 156480
tagcaaatta tatcttatat cttgggtatc ctaggtttgg ggctaatatc cacttatcag 156540
tgaatacata ttgtgtgagt ttctttgtga atgtgttacc tcactcagga tgatgccctc 156600
taggtccatc catttggcta ggaatttcat aaattcattc tttttaatag ctgagtagta 156660
ctccattgtg tagatgtacc acattttctg tatccattcc tctgttgagg ggcatctagg 156720
ttctttccag cttctggcta ttataaataa ggctgctatg aacatagtgg agcatgtgtc 156780
cttcttacct gttggggcat cttctggata tatgcccagg agaggtattg ctggatcctc 156840
cggtagtact atgtccagtt ttctgaggaa ccgccagact gatttccaga gtggttgtac 156900
aagcctgcac tcccaccaac aatggaggag tgttcctctt tctccacatc ctcgccagca 156960
tctgctgtca cctgaatttt tgatcttagc cattctgact ggtgtgaggt ggaatctcag 157020
ggttgttttg atttgcattt ccctgatgat taaggatgtt gaacattttt tcaagtgctt 157080
ctctgccatt cggtattcct caggtgagaa ttctttgttc agttctgagc cccatttttt 157140
aatggggtta tttgattttc tgaagtccac cttcttgagt tctttatata tgttggatat 157200
tagtccccta tctgatttag gataggtaaa gatcctttcc caatctgttg gtggtctttt 157260
tgtcttattg acggtgtctt ttgccttgca gaaactttgg agtttcatta ggtcccattt 157320
gtcgattttc gatcttacag cacaagccat tgctgttctg ttcaggaatt tttcccctgt 157380
gcccatatct tcaaggcttt tccccacttt ctcctctata agtttcagtg tctctggttt 157440
tatgtgaagt tccttgatcc acttagattt gaccttagta caaggagata agtatggatc 157500
gattcgcatt cttctacacg ataacaacca gttgtgccag caccaattgt tgaaaatgct 157560
gtctttcttc cactggatgg ttttagctcc cttgtcgaag atcaagtgac cataggtgtg 157620
tgggttcatt tctggatctt caattctatt ccattggtct acttgtctgt ctctatacca 157680
gtaccatgca gtttttatca cagttgctct gtagtaaagc tttaggtctg gcatggtgat 157740
tccgccagaa gttcttttat ccttgagaag actttttgct atcctaggtt ttttgttatt 157800
ccagacaaat ttgcaaattg ctccttccaa ttcgttgaag aattgagttg gaattttgat 157860
ggggattgca ttgaatctgt agattgcttt tggcaagata gccattttta caatgttgat 157920
cctgccaatc catgagcatg ggagatcttt ccatcttctg agatcttctt taatttcttt 157980
cttcagagat ttgaagtttt tatcatacag atctttcacc tccttagtta gagtcacgcc 158040
aagatatttt atattatttg tgactattga gaagggtgtt gtttccctaa tttctttctc 158100
agcctgttta ttctttgtat agagaaaggc cattgacttg tttgagttta ttttatatcc 158160
agctacttca ccgaagctgt ttatcaggtt taggagttct ctggtagaat ttttagggtc 158220
acttatatat actatcatat catctgcaaa aagtgatatt ttgacttcct cttttccaat 158280
ttgtatcccc ttgatctcct tttgttgtcg aattgctctg gctaatactt caagtactat 158340
gttgaaaagg tagggagaga gtgggcagcc ttgtctagtc cctgatttta gtgggattgc 158400
ttccagcttc tctccattta ctttgatgtt ggctactggt ttgctgtaga ttgcttttat 158460
catgtttagg tatgggcctt gaattcctga tctttccaaa acttttatca tgaatgggtg 158520
ttggatcttg tcaaatgctt tttctgcatc taacgagatg atcatgtggt ttttgtcttt 158580
gagtttgttt atataatgga ttacattgat ggattttcgt atattaaacc atccctgcat 158640
ccctggaata aaacctactt ggtcaggatg gatgattgct ttaatgtgtt cttggattcg 158700
gttagcgaga attttattga ggatttttgc atcgatattc ataagagaaa ttggtctgaa 158760
gttctctatc tttgttggat ctttctgtgg tttaggtatc agagtaatag tggcttcata 158820
aaatgagttg ggtagagtac cttctacttc tattttgtga aatagtttgt gcagaattgg 158880
aattagatct tctttgaagg tctgatagaa ctctgcacta aacccatctg gtcctgggct 158940
ttttttggtt gggagactat taataactgc ttctatttct ttaggtgata tgggactgtt 159000
tagatggtca acttgatcct gattcaactt tggtacctgg tatctgtcca gaaatttgtc 159060
catttcgtcc aggttttcca gttttgttga gtatagcctt ttgtagaagg atctgatggt 159120
gttttggatt tcttcaggat ctgttgttat gtctcccttt tcatttctga ttttgttaat 159180
taggattttg tccctgtgcc ctttagtgag tctagctaag ggtttatcta tcttgttgat 159240
tttctcaaag aaccaactcc tcgtttggtt aattctttga atacttcttc ttgtttccac 159300
ttggttgatt tcacccctga gtttgattat ttcctgccgt ctactcctct tgggtaaatt 159360
tgcttccttt ttttctaggg cttttagatg tgttgtcaag gtgctagtat gtgctgtctc 159420
tcgtttcttc ttggaggcac tcagcgctat gagtttccct cttagaaatg ctttcattgt 159480
gtcccatagg tttgggtacg ttgtggcttc attttcatta aactctaaaa agtctttaat 159540
ttctttcttt attccttcct tgaccaaggt atcattgaga agagtgttat tcagtttcca 159600
cgtgaatgtt ggctttccat tatttatgtt gttattgaag atcagtctta ggccatggtg 159660
gtctgatagg atacatggga caatttcaat atttttgtat ctattgaggc ctgttttgtg 159720
accaattata tggtcaattt tggagaaggt cccgtgaggt gctgagaaga aggtatatcc 159780
ttttgtttta ggataaaatg ttctgtagat atctgtcagg tccatttgtt tcataacttc 159840
tgttagtttc actgtgtccc tgtttagttt ctgtttccac gatctgtcct ttgaagaaag 159900
tggtgtgttg aagtctccca ctattattgt gtgaggtgca atgtatgctt tgagctttac 159960
taaagtgtct ctaatgaatg tggctgccct tgcatttggt gcgtagatat tcagaattga 160020
gagttcctct tggaggattt tacctttgat gagtatgaag tgtccctcct tgtctttttt 160080
gataactttg ggttggaagt cgattttatc cgatattaaa atggctactc cagcttgttt 160140
cttcagtcga tttgcttgga aaattgtttt ccagcctttc actctgaggt agtgtctgtc 160200
tttttccctg agatgggttt cctgtaagca gcagaatgtt gggtcctgtt tgtgtagcca 160260
gtctgttagt ctatgtcttt ttattgggga attgagtcca ttgatattaa gagatattaa 160320
ggaaaagtaa ttgttgctcc cttttatttt tgttgttaga gttggcattc tgttcttgtg 160380
gctgtcttct ttttggtttg ttgaatgatt actttcttgg ttgttctagg gcgtgatttc 160440
cgtccttgta ttgcttcttt tctgttatta tcctttgaag ggctggattc gtggaaagat 160500
attgtgtgaa tttggttttg tcgtggaata ctttggtttc tccatctatg gtaattgaga 160560
gtttggccgg gtatagtagc ctgggctggc atttgtgttc tcttagtgtc tgtataacat 160620
ctgtccaggc tcttctggct ttcatagtct ctggtgaaaa gtctggtgta attctgatag 160680
gccttccttt atatgttact tgacctttct cccttactgc ttttaatatt ctatctttat 160740
ttagtgcatt tgttgttctg attattatgt gtcgggagga atttcttttc tggtccagtc 160800
tatttggagt tctgtatgct tcttgtatga tcatgggcat ctcttttttt atgtttggga 160860
agttttcttc tattattttg ttgaagatat tagctggccc tttaagttga aaatcttcat 160920
tctcatcaat tcctattatc cgtaggtttg gtcttctcat tgtgtcctgg attacctgga 160980
tgttttgagt taggatcctt ttgcattttg tattttcttt gactgttgtg tcgatgttct 161040
ctatggaatc ttctgcacct gagattctct cttccatttc ttgtattctg ttgctgatgc 161100
tcgcatctat ggttccagat ctctttccta gggtttctat ctccagcgtt gcctcgcttt 161160
gggttttctt tattgtgtct acttcccctt ttagttctag tatggttttg ttcatttcca 161220
tcacctgttt ggctgtgttt tcctgctttt ctttaagagc ctgtaactct ttagcagtgc 161280
tctcctgtaa atctttaagt gacttatgaa agtccttctt gatgtcctct atcatcatca 161340
tgagaaatgt ttttaaatct gggtctagat tttcggttgt gttggggtgc ccaggactag 161400
gtggggtggg agtgctgcgt tctgatgatg gtgagtggtc ttgatttctg ttagtaggat 161460
tcttacgttt gcctttcgcc atctggtaat ctctgaagct agctgtttta gttgtcactg 161520
ttaagagctt gttcttcagg tgactctgtt agcctctatg agcagacctg gagggtagca 161580
ctctccttag tttcagtggg cagagtattc tctgcaggca agctctcttc ttgcaaggca 161640
ggtacccaga tatctggtgt tcgaaccaga ctcctggcag aagttgtgtt ccactcacta 161700
gaggtcttag gatcacgtgt ggaatcctgt gtgggccctt gcgggtgtca ggcgactcag 161760
ctggcaaggt agccggggct cgagtggagt ggaaggggtt tgtgccccag atcaagcccg 161820
ggtagcctgc ttccctatgt accgcagtct caagttccac gcgattggat tggggtaggc 161880
gctgtgttcc actcaccaga ggtcttaggg tcccgtgggg agtcccgtgt ggacccttgc 161940
gggtgttggg caagactctg ctggcaaggt agcccggggc tcgagtctcg agtcgagcag 162000
aagggacttg tgccccagat caggcccggg tagcctgctt ccctatgtac cgcagtctca 162060
agttccgcgc gattggattg gggcaggcac tgtgatccac tcaccagagg tcttagggtc 162120
ccgtggggag tcccgtgtgg acccttgcgg gtgttgggca agactctgct ggcaaggtag 162180
cccggggctc gagtctcgag tcgagcggaa gggacttgtg ccccagatca ggcccgggta 162240
gcctgcttcc ctatgtaccg cagtctcaag ttccgcgcga ttggattggg gcaggcactg 162300
tggtccactc accagaggtc ttagggtccc gtggggagtc ccgtgtggac ccttgcgggt 162360
gttgggcaag actctgctgg caaggtagcc cggggctcga gtctcgagtc gagcggcgaa 162420
ttgatccatt cttatctcct tgtacaaagc tcaaaagtaa gtggattaaa gacctccata 162480
taaaagcaga gacactgaaa tttatagagg agaaagtggg gaaaagcctc gaagatatgg 162540
gcacagggga aaaattccta aacagaacag caatggcttg tgctgtaaga tcaagaattg 162600
gaaaatggaa cctcacaaaa ttgcatagct tctgtaaggc aaaagacacc gtcaataaga 162660
caaaaaggcc accaactgat tgggaaagga tttttaccaa tcctaaatct gatatgggac 162720
taatatccaa tatatacaaa gagctcaaga agttagactc ccgaaattca aataatccca 162780
ttaaaaacgg ggtacagagc taaacaaaga attctcaagt gaggaatacc aaagggctga 162840
gaagcacctg aaaaaatgtt caacatcctt aatcatcagg gaaatgcaaa tcaaaacaac 162900
cttgagattc cacctcacac cagtcagaat ggctaagatc aaaaattcag gtgacagtag 162960
atgctggcga ggacgtggag aaagaggaat aatcctccat tgctggtagg attgcaagct 163020
tgtacaacca ctctggaagt cagtcttgtg gtttctcaga aaattggaca tagtactgct 163080
ggaagatcca gcaatacctc tcctgggtat atacccagaa gatgttccaa ctggtaataa 163140
ggacacatgc tccactattt tcatagcagt gttatttata atagccagaa gctggaaaga 163200
acccagatgt ccctcaacag aggaatggat aaagaaaatg tggtacattt attcaatgga 163260
gtactactca gctatttaaa acaatgaatt tatgaaattc ttgggcaaat ggatggatct 163320
ggaggatatc atccttagtg aggtaaccca atcacaaaag atttcaccag atatgcactc 163380
agataagtgg atattaacct agaaacttag aatacccaag atacaacttc caaaacacaa 163440
gaaaatcaag aagaaggaag accaatatgt ggatacttag aataaggaac aaaatagcca 163500
tgaaaggagt tatagagatg aagtttagag ttaagacaaa agggtggact atccagagac 163560
taccccatct tgggatccat cagccactaa acccagatac tattgcatat gccagcaaga 163620
ttttgctgaa gggaccctga tatagctgtc tcatatgagg ctctgccagt gcctggcaaa 163680
tacagaagtg gatactcaca gtcatctatt ggatggaaca cagggcctcc aatggaggag 163740
ctagagaaag tacccaagga gctgaaggga tctgcaaccc tatagatgga acaagaatat 163800
gaactaacca gtacccccag aggtcatatc tctagctgca tatgtagcag aagatggcct 163860
agtcggccat cagtgggaag agaggcccct aggtcttgca aactttatat gccccagtac 163920
aggggaacgc cagagtcaag aagtgggagt gggtgggtag gggatcaggg tcgggagagg 163980
gtatagggaa ctttcgggat agcatttgaa atgtaaataa agaaaacatc taataaaata 164040
gcaataaaga ataaccacta caaagagaga aaaggacaac aaaagcctgc agtaagtttg 164100
ctagctgaac agagcagatg aataaccggc agcagacttt gcaccacatc atttcctttg 164160
gccatccgca cagattgccg gaacaggcaa accagatctc catgcattct gttgtcccca 164220
ccctctgggc cataggactt ggacaaaggt aatgtcctgg atctgaaaga agttaagaca 164280
ctgggatggt atttaattaa ataataacag aggctcaact cggtgattgg cctggctgga 164340
ccagcctgat gtgttgataa ttgtctaatc ctctagtgga tatcaaaaaa aatcattgct 164400
ttcccaaggg aaggggacag ccaggagaag gagaggtata catggatgat aaacgttcca 164460
gatactggct aagtgcttac cagtaaattg aagtccacat ttcacagcat actccaggaa 164520
gtcatttctc cccagccaga ctcaacagtc tttgaaggct tctaaagtcc agctgggagg 164580
tagtgttgag cctctagcat gtctattcat agactactag atcccatgag agctgccatt 164640
acaattgctg gagtacattt tttcacttcc tatcacctaa ataaacttca cccactgtgt 164700
gggtttgcta atcccttcct catccttgct gtatccacca ccctgtcttg tttccttagc 164760
aactagacac tgctgagggc agggcagaag gctaaaaggg agcaccagta agtggaatga 164820
gtgagtggtg gcttggtggg ctgcagaggg gttagttctc acgttgcctt tttgagtatt 164880
ccccatcatt ttctcttcta gtgcgcaagt gcagggtcct cacatctatc cacactgtcc 164940
acacagagag aacacatttt taaaagctag cccaaagaga gaacaaagag ctgaggataa 165000
ctattcctaa cccaggatgt ctgccttaca ttacttttta ggtactttgc atttgtttgc 165060
tgctactatc attgtttgtt tactatattt taggagttcg aacaatccca ggcaccattc 165120
agacagaaag tggcaaatgt catctaaaag ggcagggctt aacattcccg tggcagtgtg 165180
tgcttcccca gtcagagaga gcactttctt gcttttactg ttttctaact cgagatttcc 165240
cccgcttttc tggagctttt ttttttttgt tgtttagctt ctcatcaaga aagtataagt 165300
tgtaggctgc gggagtgtct gtggggatgc gtttgttttg tttttgagac agagtttggc 165360
tatttagaga aggctagctt tgaactccca gagacccacc tgcttgtctc aagtgctggc 165420
actgaaagta tgtgtccaca tacctggcct cgtgtactaa ttttttgata attacaaaaa 165480
agggcaagaa aaaaagaaag aaagaaaatt tctttcttca gccattcatt ctgtagcctg 165540
ttgtgtccaa cactgatcta ggcattcttt tggggtactt gagcagaaag actagactgt 165600
gtactttcta gctgggctct tcaccagcag gtgcacattt cagtatttat ttggccactt 165660
gaaaatctca ctgttgattt tgtgataaaa aaaaaaaaca aaacccagga acttatttgt 165720
aaaacgatta ttcctggtgt ttatctgact caccttatca tctgtgttta aagattggtg 165780
gggtacactc tgagctattt gtacttggca agatccccaa ctctgagagc aaggttttag 165840
ctggctagtt ttcctccttc agcctctgcc aagtgcttgg tcctctagag aataatatgt 165900
accttttgtc cccacatatt aaatacaaat aaagagaaga acatgtcatc ttgaggcatt 165960
ggaagctatt aaggctatct caggcaatct ggacaactct acgccttggt cacatagtgg 166020
cttcttaata tgtaccatgg ctcactcaag aaaaatggag tggtgaccaa cttcagcctc 166080
tgagttttga gatggagact ctgagatagc tgtcaatatt ttgtaaaact gcttcctaac 166140
atcccgtacc cctttctgta tgtatatctg catgcacatg cacacatatg ggtatagagc 166200
ccgcactggc caaaagatga gagcagatct ccctggatcc agaattatat atggttgtga 166260
gcttccctat attgctgctg agagccaatc cagttctctg gaagagcaat actcactctc 166320
aactgctcag tcgcctctac aaaccaactg ttttttgttt gtttgtttgt ttgtttgttt 166380
gtctgtttgg tttggtttgg tttctcttag acagggtctc tgactgggac cgaggcttgc 166440
tgagtagggt aggctatttg accagcagcc ctcaggaatg caagtatttt cctcaacatc 166500
tgatttcctc tttcctttct ccctccctcc ctccctccct ccctccctcc ctccctccct 166560
cccttcctta atttcttcct ttcttctttc tttcttcctc cttccccctc tcttcccctc 166620
tctctctttc tttttttcca ttgccgacat gaagaagtag agatgagcat gaccaaggtc 166680
agtttctgct tttcctgtga caagggttct ccccagtcaa ccctggtctg cccacagaat 166740
tcttatccca ctgaaaggaa tagacatttc cctacatgaa gagttgtaaa gtggtggttg 166800
gtcccattgc atgcacagag agtgagagac gggtaacctg tgagacacct cctacataaa 166860
aagagttcca gtgatcttca aagtgtttgt cactcaccca gaaaaactcc agctcctcac 166920
taccaagcct aggaaaggaa gacagaaata cctagagagg aattccaatc acctcaagaa 166980
aaatggagta gtgaccagct tcagcctctg agttttgaga tggagactct gagagagctg 167040
tcaatatttt gtaaaaccgt ttcccactcg atagcattcc cagagtgaag gtttttctct 167100
cctcagccat gagctaggct tctggatttc tacatcctgt ttcatttgtg ttcttcctcc 167160
tatatttaag tgtaagcttg aatgagcgtc tcagttcact tcccacaata cgagaatttc 167220
ccaaacaagg agggcacacc aaactcatgt tagcagtgcc tcttcaggtg ttgcccattt 167280
ttctccttca aaagtcccca agcctcccag gtactacttt gccagttcag gttgttcagg 167340
ggaggtacac caagtgctga ttcccactga gctcctactg accctattca gtattgtgcc 167400
acagtttacc cttctcttct cttctcttct cttctcttct cttctcttct cttctcttct 167460
cttctcttct cttctcttct cttctcttct cttctctcct ctcctctcct ctcctctcct 167520
ctcctctcct ctcctctcct ctcctctcct ctcctctcct ctcctctcct ctcctctcct 167580
ttcccctccc ctcccctccc cctcccctcc cctcccctcc ccctcccctc ccctcccctc 167640
ccctcccctc ccctcccctc ccctcccctc ccctcccctc cttttctttt cttttctttt 167700
cttttctttt cttttctttt cttttctttt cttttctttt cttttctttt cttttctttg 167760
tgataggctt gggaagcttc ccctgcagga ctgtggagct cttgtgttca catttgtgcc 167820
ttttggaaag atgcttcagc ggctggaccc gaggcaagag tttgtcttca aaatgctgcc 167880
attgcctctg tcagttttca tctgcctgta aacttttttt ttttcttttt gccaaatctc 167940
ctgaagcaac ttgacctcaa ggtttttttt ttttaattcc ctcaactctt tctttattct 168000
ttgttccatt ttcactatct tttttttctt attagttaag agaaaccaaa gaattgattc 168060
acctgctcat tagttttctc gaatattccc ctgtgactaa agtaaaacta ggctacaccc 168120
ctaagagaaa gatgcctctt agggctcctg tcatcttcct attgtcttga ctggtgtgca 168180
tacaaagttt gaactatgaa actagggcat ggctgatttt ggctccagtg tttacttgtg 168240
aaccagtcta ttcactattg acctagcttt cagattccac agcccttcta gcttccctaa 168300
cataaaaaca taagcattat atgtatttag gaagtatcat gttgtgttcc aataatattt 168360
atgcagtttg acctcagttg tgcccttaat ccttgtagta cctgttttag ttagggtttt 168420
actgctgtga acaggcacca tgaccaagtc aactcataaa aacaacattt agtttgagct 168480
ggcttataaa ttcagaggtt cccaccaatg tcatcaaggt gggaacacga tagtgttcag 168540
gccgatatgg tgcaagagga gctgagagtt gtacattatc ataggaaggc tgctagcaga 168600
atagtgactt ccgggcagct aggatgaaga tcttaaagcc cacacccaca agagcacacc 168660
tactccaaca ggaccacacc ttctaatagt gccactccct gggccaagca tattcaaagc 168720
atcacagtat cttaattaga aaagtgggag ctatcccttg ttcatctgtc ttagttgtct 168780
tgactgctat aacaaaacac ctcaaactca ttcattcaca aag 168823
<210> 17
<211> 3294
<212> DNA
<213> 人工()
<220>
<223> 合成
<400> 17
atggggaccc gggcaagcag catcaccgcc ctcgcctctt gcagccgcac cgccggccaa 60
gtcggagcca cgatggtcgc cggctctctt ctcctgcttg gattcctcag caccatcaca 120
gcttggtaca ttctggtgcc aagtgtggcc attcccctgg ctatcgcctt cctcttcttc 180
ttcatctgtg tgtgccgcaa taaccagaag tcttcatcag gtaccgattt aaatgatcca 240
gtggtcctgc agaggagaga ttgggagaat cccggtgtga cacagctgaa cagactagcc 300
gcccaccctc cctttgcttc ttggagaaac agtgaggaag ctaggacaga cagaccaagc 360
cagcaactca gatctttgaa cggggagtgg agatttgcct ggtttccggc accagaagcg 420
gtgccggaaa gctggctgga gtgcgatctt cctgaggccg atactgtcgt cgtcccctca 480
aactggcaga tgcacggtta cgatgcgccc atctacacca acgtgaccta tcccattacg 540
gtcaatccgc cgtttgttcc cacggagaat ccgacgggtt gttactcgct cacatttaat 600
gttgatgaaa gctggctaca ggaaggccag acgcgaatta tttttgatgg cgttaactcg 660
gcgtttcatc tgtggtgcaa cgggcgctgg gtcggttacg gccaggacag tcgtttgccg 720
tctgaatttg acctgagcgc atttttacgc gccggagaaa accgcctcgc ggtgatggtg 780
ctgcgctgga gtgacggcag ttatctggaa gatcaggata tgtggcggat gagcggcatt 840
ttccgtgacg tctcgttgct gcataaaccg actacacaaa tcagcgattt ccatgttgcc 900
actcgcttta atgatgattt cagccgcgct gtactggagg ctgaagttca gatgtgcggc 960
gagttgcgtg actacctacg ggtaacagtt tctttatggc agggtgaaac gcaggtcgcc 1020
agcggcaccg cgcctttcgg cggtgaaatt atcgatgagc gtggtggtta tgccgatcgc 1080
gtcacactac gtctgaacgt cgaaaacccg aaactgtgga gcgccgaaat cccgaatctc 1140
tatcgtgcgg tggttgaact gcacaccgcc gacggcacgc tgattgaagc agaagcctgc 1200
gatgtcggtt tccgcgaggt gcggattgaa aatggtctgc tgctgctgaa cggcaagccg 1260
ttgctgattc gaggcgttaa ccgtcacgag catcatcctc tgcatggtca ggtcatggat 1320
gagcagacga tggtgcagga tatcctgctg atgaagcaga acaactttaa cgccgtgcgc 1380
tgttcgcatt atccgaacca tccgctgtgg tacacgctgt gcgaccgcta cggcctgtat 1440
gtggtggatg aagccaatat tgaaacccac ggcatggtgc caatgaatcg tctgaccgat 1500
gatccgcgct ggctaccggc gatgagcgaa cgcgtaacgc gaatggtgca gcgcgatcgt 1560
aatcacccga gtgtgatcat ctggtcgctg gggaatgaat caggccacgg cgctaatcac 1620
gacgcgctgt atcgctggat caaatctgtc gatccttccc gcccggtgca gtatgaaggc 1680
ggcggagccg acaccacggc caccgatatt atttgcccga tgtacgcgcg cgtggatgaa 1740
gaccagccct tcccggctgt gccgaaatgg tccatcaaaa aatggctttc gctacctgga 1800
gagacgcgcc cgctgatcct ttgcgaatac gcccacgcga tgggtaacag tcttggcggt 1860
ttcgctaaat actggcaggc gtttcgtcag tatccccgtt tacagggcgg cttcgtctgg 1920
gactgggtgg atcagtcgct gattaaatat gatgaaaacg gcaacccgtg gtcggcttac 1980
ggcggtgatt ttggcgatac gccgaacgat cgccagttct gtatgaacgg tctggtcttt 2040
gccgaccgca cgccgcatcc agcgctgacg gaagcaaaac accagcagca gtttttccag 2100
ttccgtttat ccgggcaaac catcgaagtg accagcgaat acctgttccg tcatagcgat 2160
aacgagctcc tgcactggat ggtggcgctg gatggtaagc cgctggcaag cggtgaagtg 2220
cctctggatg tcgctccaca aggtaaacag ttgattgaac tgcctgaact accgcagccg 2280
gagagcgccg ggcaactctg gctcacagta cgcgtagtgc aaccgaacgc gaccgcatgg 2340
tcagaagccg ggcacatcag cgcctggcag cagtggcgtc tggcggaaaa cctcagtgtg 2400
acgctccccg ccgcgtccca cgccatcccg catctgacca ccagcgaaat ggatttttgc 2460
atcgagctgg gtaataagcg ttggcaattt aaccgccagt caggctttct ttcacagatg 2520
tggattggcg ataaaaaaca actgctgacg ccgctgcgcg atcagttcac ccgtgcaccg 2580
ctggataacg acattggcgt aagtgaagcg acccgcattg accctaacgc ctgggtcgaa 2640
cgctggaagg cggcgggcca ttaccaggcc gaagcagcgt tgttgcagtg cacggcagat 2700
acacttgctg atgcggtgct gattacgacc gctcacgcgt ggcagcatca ggggaaaacc 2760
ttatttatca gccggaaaac ctaccggatt gatggtagtg gtcaaatggc gattaccgtt 2820
gatgttgaag tggcgagcga tacaccgcat ccggcgcgga ttggcctgaa ctgccagctg 2880
gcgcaggtag cagagcgggt aaactggctc ggattagggc cgcaagaaaa ctatcccgac 2940
cgccttactg ccgcctgttt tgaccgctgg gatctgccat tgtcagacat gtataccccg 3000
tacgtcttcc cgagcgaaaa cggtctgcgc tgcgggacgc gcgaattgaa ttatggccca 3060
caccagtggc gcggcgactt ccagttcaac atcagccgct acagtcaaca gcaactgatg 3120
gaaaccagcc atcgccatct gctgcacgcg gaagaaggca catggctgaa tatcgacggt 3180
ttccatatgg ggattggtgg cgacgactcc tggagcccgt cagtatcggc ggaattccag 3240
ctgagcgccg gtcgctacca ttaccagttg gtctggtgtc aaaaataata ataa 3294

Claims (46)

1.一种经基因工程改造的啮齿动物，在其基因组中包含经修饰的内源性DR6基因座，所述经修饰的内源性DR6基因座缺少编码整个DR6蛋白的胞质结构域的第一核苷酸序列。
2.根据权利要求1所述的经基因工程改造的啮齿动物，其中所述经修饰的内源性DR6基因座还缺少编码整个成熟DR6蛋白的第二核苷酸序列。
3.根据权利要求1或权利要求2所述的经基因工程改造的啮齿动物，其中所述经修饰的内源性DR6基因座包含编码功能性DR6信号肽的核酸序列，所述功能性DR6信号肽可操作地融合至跨膜结构域和报告基因蛋白中的至少一者。
4.根据权利要求3所述的经基因修饰的啮齿动物，其中所述核酸序列编码可操作地融合至所述跨膜结构域的所述功能性DR6信号肽，并且其中所述跨膜结构域可操作地融合至所述报告基因蛋白。
5.根据权利要求3或权利要求4所述的经基因修饰的啮齿动物，其中所述功能性DR6信号肽为内源性DR6信号肽。
6.根据权利要求3至5中任一项所述的经基因修饰的啮齿动物，其中所述跨膜结构域不是内源性DR6跨膜结构域。
7.根据权利要求3至6中任一项所述的经基因修饰的啮齿动物，其中所述跨膜结构域为ROR1跨膜结构域。
8.根据权利要求3至7中任一项所述的经基因修饰的啮齿动物，其中所述报告基因蛋白为β半乳糖苷酶。
9.根据权利要求3至8中任一项所述的经基因修饰的啮齿动物，其中所述核酸序列可操作地连接至内源性DR6转录调控序列。
10.根据权利要求1至9中任一项所述的经基因修饰的啮齿动物，其中所述经基因修饰的啮齿动物对于所述经修饰的内源性DR6基因座是杂合的。
11.根据权利要求1至10中任一项所述的经基因修饰的啮齿动物，其中所述啮齿动物表现出运动神经元功能紊乱。
12.根据权利要求11所述的经基因修饰的啮齿动物，其中所述运动神经元为上运动神经元或下运动神经元。
13.根据权利要求12所述的经基因修饰的啮齿动物，其中在所述啮齿动物大于4周龄以前，所述运动神经元功能紊乱在盲法主观神经系统评分测定、转杆测试、猫步测试、旷场测试和体重测量中并不明显。
14.根据权利要求1至13中任一项所述的经基因修饰的啮齿动物，其中与对照啮齿动物相比，所述啮齿动物表现出伤害感受减弱。
15.根据权利要求1所述的经基因修饰的啮齿动物，其中所述啮齿动物为大鼠或小鼠。
16.根据权利要求15所述的经基因修饰的啮齿动物，其中所述啮齿动物为包含经修饰的内源性DR6基因座的小鼠，所述经修饰的内源性DR6基因座缺少编码整个成熟DR6蛋白的第一核苷酸序列，并且其中所述内源性小鼠DR6基因座包含可操作地连接至至少一个内源性DR6转录调控序列，即编码内源性DR6信号肽的核酸序列，所述内源性DR6信号肽可操作地融合至ROR1跨膜结构域，所述ROR1跨膜结构域可操作地融合至β-半乳糖苷酶。
17.根据权利要求16所述的经基因修饰的啮齿动物，其中所述小鼠来自选自129品系、C57BL/6品系和混合C57BL/6×129品系的品系，并且其中在介于8周龄和20周龄之间，所述小鼠与对照野生型动物相比表现出体重增加减缓。
18.一种来源于根据权利要求1至17中任一项所述的经基因修饰的啮齿动物的细胞或组织。
19.根据权利要求18所述的细胞或组织，其中所述细胞为运动神经元或胚胎干细胞。
20.一种产生根据权利要求1所述的经基因修饰的啮齿动物的方法，所述方法包括从所述啮齿动物的内源性DR6基因座缺失编码整个DR6胞质结构域的第一内源性核苷酸序列的步骤。
21.根据权利要求20所述的方法，其中所述缺失步骤包括用编码跨膜结构域和/或报告基因的核酸序列替换编码全长和内源性成熟DR6蛋白的第二内源性核苷酸序列，其中所述核酸与内源性DR6转录调控和信号肽序列可操作地连接。
22.一种产生与对照运动神经元细胞相比表现出氧化应激反应增加的运动神经元群的方法，所述方法包括由从根据权利要求1至17中任一项所述的啮齿动物分离的内细胞团胚胎干细胞形成胚体，以及将所述胚体分化成所述运动神经元群。
23.一种筛选候选试剂以用于调节运动神经元功能紊乱的方法，所述方法包括：
(a)向在其基因组中包含经修饰的内源性DR6基因座的啮齿动物施用候选试剂，所述经修饰的内源性DR6基因座缺少编码整个DR6胞质结构域的第一核苷酸序列，其中所述啮齿动物表达出运动神经元功能紊乱；以及
(b)确定相比于测试对照啮齿动物，所述候选试剂对所述啮齿动物的所述运动神经元功能紊乱的至少一种症状的任何调节作用；
其中相比于所述测试对照啮齿动物，存在对所述啮齿动物的所述运动神经元功能紊乱的所述至少一种症状的调节作用表示所述候选试剂能够用于调节运动神经元功能紊乱。
24.根据权利要求23所述的方法，其中所述经修饰的内源性DR6基因座还缺少编码整个成熟内源性DR6蛋白的第二核苷酸序列。
25.根据权利要求23或权利要求24所述的方法，其中所述经修饰的内源性DR6基因座包含编码功能性DR6信号肽的核酸序列，所述功能性DR6信号肽可操作地融合至跨膜结构域和报告基因蛋白中的至少一者。
26.根据权利要求23至25中任一项所述的方法，其中在通过盲法主观ALS-TDI神经系统评分、转杆测试、猫步测试、旷场测试、体重测量或确定对疼痛刺激作出反应的延迟时间来检测所述症状之前施用所述试剂。
27.根据权利要求23至26中任一项所述的方法，其中在通过盲法主观ALS-TDI神经系统评分、转杆测试、猫步测试、旷场测试、体重测量或确定对疼痛刺激作出反应的延迟时间中的一者或多者来检测所述症状之后施用所述试剂。
28.根据权利要求23至27中任一项所述的方法，其中在两个或更多个不同的时间点施用所述试剂。
29.根据权利要求23至28中任一项所述的方法，其中相比于品系与所述啮齿动物相同但在其基因组中不包含所述核酸的对照啮齿动物，所述至少一种症状选自驼背、异常后肢抱握、运动协调缺陷、运动学习能力缺陷、体重减轻以及感知缺陷。
30.根据权利要求23至29中任一项所述的方法，其中所述至少一种症状由上运动神经元功能紊乱引起。
31.根据权利要求30所述的方法，其中所述至少一种症状选自震颤、痉挛性麻痹(僵直)、反射异常以及它们的组合。
32.根据权利要求23至29中任一项所述的方法，其中所述至少一种症状由下运动神经元功能紊乱引起。
33.根据权利要求32所述的方法，其中所述至少一种症状选自肌无力和消瘦、肌束震颤以及它们的组合。
34.根据权利要求23至33中任一项所述的方法，其中运动神经元功能紊乱的所述至少一种症状为体重增加减缓。
35.根据权利要求23至34中任一项所述的方法，其中运动神经元功能紊乱的所述至少一种症状为伤害感受减弱。
36.根据权利要求23至35中任一项所述的方法，其中所述啮齿动物为包含经修饰的内源性DR6基因座的小鼠，所述经修饰的内源性DR6基因座缺少编码整个成熟DR6蛋白的第一核苷酸序列，并且
其中所述内源性小鼠DR6基因座包含可操作地连接至至少一个内源性DR6转录调控序列，即编码内源性DR6信号肽的核酸序列，所述内源性DR6信号肽可操作地融合至ROR1跨膜结构域，所述ROR1跨膜结构域可操作地融合至β-半乳糖苷酶。
37.根据权利要求36所述的方法，其中所述小鼠来自选自129品系、C57BL/6品系以及混合C57BL/6×129品系的品系。
38.一种用于筛选用于减少运动神经元中的氧化应激反应的候选试剂的方法，所述方法包括
(a)在存在或不存在试剂的情况下培养来源于根据权利要求1所述的啮齿动物的运动神经元；
(b)确定与来源于所述啮齿动物但在不存在所述试剂的情况下培养的对照运动神经元相比，所述试剂是否预防、抑制和/或减少所述运动神经元中的氧化应激反应；其中所述运动神经元中的氧化应激反应的所述预防、抑制和/或减少表明候选试剂用于减少运动神经元中的氧化应激反应。
39.一种核酸，所述核酸包含可操作地连接并从5'至3'的编码DR6信号肽的第一核酸序列、编码跨膜结构域的第二核酸序列、编码报告基因的第三核酸序列和/或编码药物选择盒的第四核酸序列。
40.根据权利要求39所述的核酸序列，其中所述第一核酸序列如SEQ ID NO:6所示，所述第二核酸序列如SEQ ID NO:7所示，所述第三核酸序列如SEQ ID NO:8所示和/或所述第四核酸序列如SEQ ID NO:3所示。
41.根据权利要求39或权利要求40所述的核酸，还包含第一靶向臂和第二靶向臂，其中所述第一靶向臂为所述第一核酸序列、所述第二核酸序列和/或所述第三核酸序列的5'并可操作地连接至所述第一核酸序列、所述第二核酸序列和/或所述第三核酸序列，其中所述第二靶向臂为所述第一核酸序列、所述第二核酸序列和/或所述第三核酸序列的3'并可操作地连接至所述第一核酸序列、所述第二核酸序列和/或所述第三核酸序列，并且其中所述第一靶向臂和所述第二靶向臂用于靶向用于插入内源性非人动物DR6基因座的所述核酸，所述内源性非人动物DR6基因座可操作地连接至至少一个内源性非人动物调控元件。
42.根据权利要求41所述的核酸，其中所述非人动物为啮齿动物。
43.根据权利要求42所述的核酸序列，其中所述啮齿动物为小鼠。
44.根据权利要求43所述的核酸序列，其中所述核酸包括如SEQ ID NO:5或SEQ ID NO:17所示的序列。
45.一种啮齿动物细胞，所述啮齿动物细胞包含根据权利要求39至44中任一项所述的核酸。
46.根据权利要求45所述的啮齿动物细胞，其中所述啮齿动物细胞为胚胎干细胞。
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