CN107669531A - A kind of pale spot skin cosmetics - Google Patents
A kind of pale spot skin cosmetics Download PDFInfo
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- CN107669531A CN107669531A CN201611138001.8A CN201611138001A CN107669531A CN 107669531 A CN107669531 A CN 107669531A CN 201611138001 A CN201611138001 A CN 201611138001A CN 107669531 A CN107669531 A CN 107669531A
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- extract
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- skin cosmetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to a kind of pale spot skin cosmetics, belong to cosmetic field.The pale spot skin cosmetics of the present invention are prepared from the following components：Herba Sedi extract, beautyberry extract, European Lee's berry extract; wide yulan seed oil, acetyl group hexapeptide 8, SP liquid; sunflower seeds oleic acid; stearic acid, lauric acid amide of ethanol, the own ester of diethylamino oxybenzene formylbenzoate; the rilanit specials of PEG 40; burnt sugar coloring, preservative, essence and deionized water.Proved by effect test, pale spot skin cosmetics freckle effect of the invention is notable, and steady quality is safely controllable, can extensive use.
Description
Technical field
The present invention relates to cosmetic field, and in particular to a kind of pale spot skin cosmetics.
Background technology
Chloasma is the yellowish-brown pigmentation spots at the facial position such as two cheeks and forehead, is symmetrically distributed in two-sided cheek, shape more
As butterfly is also known as butterfly macules, medical science is also known as " chloasma hepaticum ", " dark abnormal pigmentary deposit on the skin ", is more common in women.It is now recognized that may with gestation, orally keep away
Pregnant medicine, endocrine, some drugses, cosmetics, heredity, trace element, liver diseases and ultraviolet etc. are relevant.
The appearance of chloasma is most relevant with endocrine, especially relevant with the serum estrogen level of women.Therefore menstruation
It is uncomfortable, take contraceptive, liver function or chronic kidney disease and can all cause the appearance of chloasma, and Exposure to Sunlight and stress can aggravate
The color of chloasma, it is rendered as the faint yellow color spot of sheet.
Therefore, nti-freckle just turns into urgent problem to be solved.The method of nti-freckle is varied in the prior art, has dietotherapy to dispel
Spot, traditional Chinese medicine freckle-removing and cosmetics whitening spot-removing etc., but its effect is unstable, is still badly in need of significant effect currently on the market
Pale spot skin cosmetics.
The content of the invention
The purpose of the present invention is overcome the deficiencies in the prior art, there is provided a kind of pale spot skin cosmetics of significant effect.
The present invention solve the technical problem technical scheme be：
A kind of pale spot skin cosmetics, are prepared from the following components：Herba Sedi extract, beautyberry extract, Europe
Continent Lee's berry extract, wide yulan seed oil, Argireline, SP liquid, sunflower seeds oleic acid, stearic acid, coconut oil diethanol
Acid amides, the own ester of diethylamino oxybenzene formylbenzoate, Cremophor RH40, burnt sugar coloring, preservative, essence and deionization
Water.
Preferably, the percentage by weight composition of each component is as follows：Herba Sedi extract 2-5%, beautyberry extract 1-
8%, European Lee's berry extract 0.5-2%, wide yulan seed oil 0.5-3%, Argireline 1-3%, SP liquid 1-8%,
Sunflower seeds oleic acid 3-6%, stearic acid 8-12%, lauric acid amide of ethanol 15-20%, diethylamino oxybenzene formylbenzoate oneself
Ester 8-15%, Cremophor RH40 8-16%, burnt sugar coloring 0.01-0.1%, preservative and appropriate essence, more than deionized water
Amount.
It is further preferred that the percentage by weight composition of each component is as follows：Herba Sedi extract 3%, callicarpa nudiflora extraction
Thing 5%, European Lee's berry extract 1%, wide yulan seed oil 1.5%, Argireline 2%, SP liquid 5%, sunflower oil
Acid 5%, stearic acid 10%, lauric acid amide of ethanol 18%, the own ester 10% of diethylamino oxybenzene formylbenzoate, PEG-40 hydrogen
Change castor oil 10%, burnt sugar coloring 0.05%, preservative and appropriate essence, deionized water surplus.
Wherein, stringy stonecrop, alias dog tooth half, stringy stonecrop herb, sun plant, poultry grass, dog teeth, melon seeds grass, are Crassulaceae
Plant stringy stonecrop Sedum sarmentosum Bunge fresh or dry herb.Summer, the harvesting of season in autumn two, remove impurity.Using fresh herb
Or dry.It is sweet, light, it is cool.There is the effect of removing dampness through diuresis and removing jaundice, clearing heat and detoxicating.It is usually used in jaundice with damp-heat pathogen, difficult urination, carbuncle swells sore.Hang down
Basin grass extract rich in N- methylisopelletierines (N-methylisopelletierine) dihydro-N-methyl isopelletierine,
The components such as sedoheptulose (sedoheptulose), glucose, fructose, sucrose.
Callicarpa nudiflora (Callicarpa nudiflora Hook.et Arn.) is Verenaceae Japanses beauty-berry platymiscium.China
On the south the main product Yangtze river basin, the province such as Jiangxi, Fujian, Guangdong, Guangxi, Hainan is distributed in.Have a moderate climate, there was dampness in the air, height above sea level
The mountain area of 100-850 rice is advantageous to callicarpa nudiflora growth.Bitter in taste, micro-pungent, put down.Anti-inflammatory, detoxify, restrain, hemostasis.For changing
Purulent inflammation, acute infectious hepatitis, burn or scald, traumatism and bleeding.Beautyberry extract complicated component, mainly contains terpene
The compositions such as class, flavonoids, benzyl carbinol glycoside.Its pharmacological action is extensive, is mainly manifested in hemostatic analgesia, anti-inflammation etc.
Effect.
The Herba Sedi extract and beautyberry extract of the present invention can use the conventional water extraction in this area or alcohol extracting side
Method is carried out.
Preferably, the preparation method of Herba Sedi extract is：Stringy stonecrop fresh feed is taken, adds water to be heated to 70-90 DEG C and carries
Take, extract solution filtration, filtrate concentration, be drying to obtain；
The preparation method of beautyberry extract is：Take callicarpa nudiflora, add 50% ethanol solution to be carried in 50-60 DEG C of heating
Take, extract solution filtration, filtrate, with 80% ethanol elution, eluent filtration, is concentrated, dried by macroporous adsorbent resin column chromatography
Produce；
The pale spot skin cosmetics of the present invention can use the conventional method of this area be prepared as liquid type cosmetics,
Type of latex type cosmetics, cream kind cosmetics, powder class cosmetics, powder compacting class cosmetics etc..
Proved by effect test, pale spot skin cosmetics freckle effect of the invention is notable, steady quality, safely may be used
Control, can extensive use.
Embodiment
The preparation of the antiallergy pale spot skin of embodiment 1 breast
Each raw material is taken by following composition：Herba Sedi extract 2-5%, beautyberry extract 1-8%, European Lee fruit extraction
Thing 0.5-2%, wide yulan seed oil 0.5-3%, Argireline 1-3%, SP liquid 1-8%, sunflower seeds oleic acid 3-6%,
Stearic acid 8-12%, lauric acid amide of ethanol 15-20%, diethylamino oxybenzene formylbenzoate own ester 8-15%, PEG-40
Rilanit special 8-16%, burnt sugar coloring 0.01-0.1%, preservative and appropriate essence, deionized water surplus are conventional by this area
Method is prepared into skin care milk.
The preparation of the antiallergy pale spot skin of embodiment 2 frost
Each raw material is taken by following composition：Herba Sedi extract 3%, beautyberry extract 3%, European Lee's berry extract
1%, wide yulan seed oil 1%, Argireline 1%, SP liquid 2%, sunflower seeds oleic acid 4%, stearic acid 8%, coconut oil
Diglycollic amide 15%, the own ester 10% of diethylamino oxybenzene formylbenzoate, Cremophor RH40 10%, burnt sugar coloring
0.02%, preservative and appropriate essence, face cream are prepared into by this area conventional method at deionized water surplus.
The preparation of the antiallergy pale spot skin liquid of embodiment 3
Each raw material is taken by following composition：Herba Sedi extract 5%, callicarpa nudiflora extraction 8%, European Lee's berry extract 2%,
Wide yulan seed oil 2%, Argireline 3%, SP liquid 6%, sunflower seeds oleic acid 5%, stearic acid 10%, coconut oil two
Glycollic amide 15%, the own ester 12% of diethylamino oxybenzene formylbenzoate, Cremophor RH40 12%, burnt sugar coloring 0.1%,
Preservative and appropriate essence, deionized water surplus, are by age prepared into shin moisturizer with conventional method.
The pale spot skin cosmetics of the present invention of embodiment 4 induce the pigmented inhibitory action research of guinea pig skin to UVB
The pure white Female guinea pigs 120 of regular grade health, body weight 250-320g are taken, every guinea pig back takes 3 phases from region
(2×2cm2), wipe out guinea pig back centre with curved scissors and become mildewed, electric shaver shaves net undercoat, uses SS-04B type ultraviolets
Phototherapeutic instrument irradiates, ultraviolet lamp configuration UVB light sources, and the spectrum peak of fluorescent tube is 310~315nm, the ultraviolet spokes of pre-irradiation application UVB
Irradiation light intensity is determined according to meter, irradiates region 20min, daily exposure 200mJ/cm2, continuous 2 weeks, cumulative exposure
2800mJ/cm2.It is administered within 2 hours after irradiation every time, irradiation continues administration 2 weeks after terminating, take skin histology to do pathologic finding.Its
In, 120 cavys are randomly divided into 6 groups：The 1st group of normal guinea pig skin of back with not irradiating ultraviolet light makees blank control group, and the 2nd
Group is using irradiating ultraviolet light but applies distilled water outside as model group, 3-5 groups, distinguishes skin care milk, the face cream for applying embodiment 1-3 outside
With shin moisturizer as experimental group, the 6th group, outer painting 0.1%8- Medadinine tinctures are as positive controls.Case control includes
Two aspects：(1) cell count containing melanin granule：Dyed with Schmorl methods, net form eyepiece micrometer mono blind method is used under high power lens
Count every square millimeter of basal layer of epidermis cell number containing melanin granule of every part of sample；(2) dopa-positive melanocytes counts：With
Imokawa methods are dyed, and every square millimeter of basal layer of epidermis of every part of sample is counted with net form eyepiece micrometer mono blind method under high power lens
Number containing dopa-positive melanocytes, as a result as shown in table 1：
The pale spot skin cosmetics of the present invention of table 1 induce the pigmented inhibitory action of guinea pig skin to UVB
| Group | Cell containing melanin granule/mm2 | DOPA sun melanocyte/mm2 |
| Blank control group | 301.43±21.41 | 151.32±18.34 |
| Model group | 450±18.31 | 240.34±21.22 |
| Skin care milk group | 322.14±11.43 | 174.54±31.12 |
| Face cream group | 331.43±12.32 | 176.23±14.54 |
| Shin moisturizer group | 334.49±21.43 | 175.54±16.21 |
| Positive controls | 328.43±18.32 | 170.32±14.34 |
As a result show：Compared with blank control group, model group guinea pig skin cell containing melanin granule, DOPA positive melanocyte are thin
Born of the same parents' number substantially increases, and illustrates that the pigmentation skin model similar to chloasma of UVB inductions is successful, and the skin care of the present invention
Breast, face cream and face cream can significantly reduce guinea pig skin cell containing melanin granule, dopa-positive melanocytes number, and act on
Suitable with positive control drug 8-MOP, illustrating the pale spot skin cosmetics of the present invention has good light spot effect.
Claims (4)
1. a kind of pale spot skin cosmetics, it is characterised in that be prepared from the following components：Herba Sedi extract, it is callicarpa nudiflora
Extract, European Lee's berry extract, wide yulan seed oil, Argireline, SP liquid, sunflower seeds oleic acid, stearic acid, cocounut oil
Sour diglycollic amide, the own ester of diethylamino oxybenzene formylbenzoate, Cremophor RH40, burnt sugar coloring, preservative, essence and
Deionized water.
2. pale spot skin cosmetics according to claim 1, it is characterised in that the percentage by weight composition of each component is such as
Under：Herba Sedi extract 2-5%, beautyberry extract 1-8%, European Lee's berry extract 0.5-2%, wide yulan seed oil
0.5-3%, Argireline 1-3%, SP liquid 1-8%, sunflower seeds oleic acid 3-6%, stearic acid 8-12%, coconut oil two
Glycollic amide 15-20%, diethylamino oxybenzene formylbenzoate own ester 8-15%, Cremophor RH40 8-16%, caramel
Color 0.01-0.1%, preservative and appropriate essence, deionized water surplus.
3. pale spot skin cosmetics according to claim 2, it is characterised in that the percentage by weight of each component preferably constitutes
It is as follows：Herba Sedi extract 3%, beautyberry extract 5%, European Lee's berry extract 1%, wide yulan seed oil 1.5%, second
Acyl group hexapeptide -8 2%, SP liquid 5%, sunflower seeds oleic acid 5%, stearic acid 10%, lauric acid amide of ethanol 18%, diethylamino
The own ester 10% of oxybenzene formylbenzoate, Cremophor RH40 10%, burnt sugar coloring 0.05%, preservative and appropriate essence,
Deionized water surplus.
4. according to the pale spot skin cosmetics described in claim any one of 1-3, it is characterised in that its formulation is made up for liquid type
Product, type of latex type cosmetics, cream kind cosmetics, powder class cosmetics, powder compacting class cosmetics etc..
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611138001.8A CN107669531A (en) | 2016-12-12 | 2016-12-12 | A kind of pale spot skin cosmetics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611138001.8A CN107669531A (en) | 2016-12-12 | 2016-12-12 | A kind of pale spot skin cosmetics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107669531A true CN107669531A (en) | 2018-02-09 |
Family
ID=61133275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611138001.8A Pending CN107669531A (en) | 2016-12-12 | 2016-12-12 | A kind of pale spot skin cosmetics |
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| Country | Link |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104352394A (en) * | 2014-11-17 | 2015-02-18 | 郭根松 | Dendrobium nobile-containing Chinese herbal medicine facial-cleanser |
| CN104546621A (en) * | 2015-01-30 | 2015-04-29 | 广州澳医生物科技有限公司 | Anti-aging skincare composition and preparation method thereof |
| CN104983624A (en) * | 2015-06-29 | 2015-10-21 | 南阳市汇博生物技术有限公司 | Repairing skin-protecting nourishing mask impregnation liquid and preparation method thereof |
| CN105078803A (en) * | 2014-05-16 | 2015-11-25 | 苏州润新生物科技有限公司 | Application of callicarpa plant extract |
-
2016
- 2016-12-12 CN CN201611138001.8A patent/CN107669531A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105078803A (en) * | 2014-05-16 | 2015-11-25 | 苏州润新生物科技有限公司 | Application of callicarpa plant extract |
| CN104352394A (en) * | 2014-11-17 | 2015-02-18 | 郭根松 | Dendrobium nobile-containing Chinese herbal medicine facial-cleanser |
| CN104546621A (en) * | 2015-01-30 | 2015-04-29 | 广州澳医生物科技有限公司 | Anti-aging skincare composition and preparation method thereof |
| CN104983624A (en) * | 2015-06-29 | 2015-10-21 | 南阳市汇博生物技术有限公司 | Repairing skin-protecting nourishing mask impregnation liquid and preparation method thereof |
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Application publication date: 20180209 |
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