CN107638502A - A kind of herbal mixture dripping pill for treating diabetes B and preparation method thereof - Google Patents
A kind of herbal mixture dripping pill for treating diabetes B and preparation method thereof Download PDFInfo
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- CN107638502A CN107638502A CN201710939632.8A CN201710939632A CN107638502A CN 107638502 A CN107638502 A CN 107638502A CN 201710939632 A CN201710939632 A CN 201710939632A CN 107638502 A CN107638502 A CN 107638502A
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Abstract
The invention discloses a kind of herbal mixture dripping pill for treating diabetes B, include the component of following parts by weight：13 parts of coptis powder, 23 parts of wind-weed powder, 12 parts of Radix Notoginseng powder, 0.01~0.03 part of papaverine, 0.02~0.04 part of aminophylline, 13 parts of mulberry leaf.A kind of herbal mixture dripping pill for treating diabetes B provided by the invention, the selected natural Chinese traditional medicines material coptis, the wind-weed, mulberry leaf, pseudo-ginseng are as bulk composition, formula is reasonable, cooperated between each component, synergy, soften vascular wall, expansion blood vessel, platelet aggregation can be significantly inhibited, reduce blood viscosity, increase CBF, ensure islet cells amount of blood supply, make its function of bringing into normal play, the metabolism of balance glucose, so as to improve the symptom of diabetes B, and finally patient is set to break away from pharmacological dependence.In addition, the herbal mixture ball also can effectively improve hypertension symptom, have no side effect to human viscera organ, through the efficient good medicine for being higher than 85%, being expected to as diabetes B Rehabilitation of clinical test checking.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation, is specifically related to a kind of herbal mixture dripping pill for treating diabetes B
And preparation method thereof.
Background technology
Diabetes B (is once called as Non-Insulin Dependent Diabetes Mellitus or maturity-onset diabetes), is metabolic disease.More 35~
The sequela of 40 years old, accounts for diabetic more than 90%.Diabetes B patient's body produces the ability of insulin and non-fully lost
Lose, but the action effect of insulin is poor, mainly stimulates the secretion of internal insulin by oral drugs at present or directly makes
Use insulin therapy.Diabetes B main clinic symptoms have：Thirsty, dry throat；Fatigue and weak；Blood pressure rises；Swell on the whole body；Abdomen
Swollen constipation；Headache and dizzy；The desquamation of skin；Biped is numb；Dermatodyschroia；Blurring of vision.
Chinese and Western medicine currently used for clinical treatment diabetes B is many, but is only used for controlling blood glucose, glucose in urine to increase
With the prevention of complication.Western medicine long-term use can produce side effect to bodily fuctions' organ, and pure Chinese medicinal preparation also simply takes stopgap measures not
Effect a permanent cure, do not solve etiology fundamentally.
The content of the invention
Inspiration of the present invention comes from the animal experiment of diabetes, finds that islet cells blood supply insufficiency causes pancreas islet from experiment
The function reduction of cell, until hypoinsulinism, glucose metabolism disorders cause posteriori diabetes B.The present invention from
Decompression, expansion blood vessel, activate blood circulation and disperse blood clots, improve microcirculation and set out, the medicine of diabetes B, specific technical scheme are treated in research
It is as follows：
A kind of herbal mixture dripping pill for treating diabetes B, include the component of following parts by weight：Coptis powder 1-3 parts, the wind-weed
Powder 2-3 parts, Radix Notoginseng powder 1-2 parts, 0.01~0.03 part of papaverine, 0.02~0.04 part of aminophylline, mulberry leaf 1-3 parts.
Further, a kind of herbal mixture dripping pill for treating diabetes B, the component of following parts by weight is included：Coptis powder 1
Part, 2 parts of wind-weed powder, 1 part of Radix Notoginseng powder, 0.01 part of papaverine, 0.02 part of aminophylline, 1 part of mulberry leaf.
Preferably, a kind of herbal mixture dripping pill for treating diabetes B, include the component of following parts by weight：Coptis powder 2
Part, 2.5 parts of wind-weed powder, 1.5 parts of Radix Notoginseng powder, 0.02 part of papaverine, 0.03 part of aminophylline, 2 parts of mulberry leaf.
Further, a kind of herbal mixture dripping pill for treating diabetes B, the component of following parts by weight is included：Coptis powder 3
Part, 3 parts of wind-weed powder, 2 parts of Radix Notoginseng powder, 0.03 part of papaverine, 0.04 part of aminophylline, 3 parts of mulberry leaf.
The source of various medicinal materials and major function are as follows used by inventive formulation：
The wind-weed, it is the dry rhizome of the liliaceous plant wind-weed.Spring, the excavation of season in autumn two, remove fibrous root and silt, dry, practise
Claim " RHIZOMA ANEMARRHENAE with peet "；Or crust is removed, dry.Major function clearing heat-fire, fluid dryness.For fever caused by exogenous pathogenic factors, hyperpyrexia polydipsia, lung
Hot cough caused by dryness, osteopyrexia and fever, Heat Diabetes, dry constipation of intestines.
The coptis, herbaceos perennial, happiness cool, moisten part, belong to Ranunculaceae Coptis.Rhizome yellow, normal branch are close
Raw most fibrous roots.Leaf whole base is given birth to；Long 5-12 (- 16) cm of petiole；Blade heavily fortified point papery, ovate triangle, wide to reach 10cm, 3 totally cleave；
Central sliver has thin handle, and ovate rhombus, long 3-8cm, wide 2-4cm, the anxious point in top, there are sharp sawtooth, function master in pinniform drastic crack, edge
Control：Purging intense heat, eliminating dampness, removing toxic substances, desinsection, row heat toxin when controlling, typhoid fever, excess heat is vexed, and feeling of fullness is vomitted inverse, bacillary dysentery, and heat rushes down stomachache, lung knot
Press, tell, be defeated in battle, lower blood, quenching one's thirst, infantile malnutrition due to digestive disturbances or intestinalparasites, roundworm disease, pertussis, abscess of throat, pinkeye, aphtha, skin sore, eczema, soup is burning hot
Wound.
Pseudo-ginseng is Umbellales Araliaceae Panax herbaceos perennial, and root-like stock is short, fleshy root cylinder, and palmate is multiple
Leaf, umbel basidixed, flower yellow green；Calyx cup-shaped.Root is used as medicine, and its is warm-natured, acrid flavour, has significant promoting blood circulation and removing blood stasis, detumescence
Analgesic therapy effect, there are " invaluable ", the good reputation of " southern part of the country god's grass ".
Papaverine is a kind of colourless prism-shaped or acicular crystal.The pharmacological action of papaverine between morphine and codeine it
Between, the spasm of smooth muscle, particularly vascular smooth muscle can be mainly released, and the excitability of cardiac muscle can be suppressed.Its hydrochloride can be controlled
Treat the disease such as angina pectoris and arterial embolism.Papaverine is a kind of opioid alkaloid antispasmodic, is had to blood vessel, heart or other smooth muscles
Direct non-specific relexation, it is probably to suppress cyclic nucleotide phosphodiesterase to cause that it, which is acted on,.To blood vessel, bronchus,
The smooth muscles such as intestines and stomach, bile duct have relexation, by relaxation vascular smooth muscle, make coronary dilation, peripheral resistance and brain blood
Pipe resistance reduces, and is mainly used in for treating the internal organ such as ischemic, kidney, courage or intestines and stomach caused by brain, the heart and peripheral vascular spasm
Spasm.
Aminophylline is theophylline and diethylamine double salt, and essentially from theophylline, ethylenediamine makes its water solubility enhancing for base pharmacological action.
It is usually used in treating the important drugs of bronchitis, there is direct relexation to airway smooth muscle.In addition, theophylline is purinoceptor
Retarding agent, the contraction to respiratory tract such as adenine can be resisted, theophylline can strengthen contraction of diaphragm power, especially contraction of diaphragm without
Effect is more notable during power, therefore is beneficial to improve respiratory function.
Mulberry leaf are the dried leafs of moraceae plants mulberry, also known as mulberry, thorn mulberry, mulberry fruit tree, yellow wood etc., organic rich in rare element
Selenium, germanium, it is natural powerful antioxidant, interior free yl can be removed, make to be accumulated in the toxin in human body and waste is oxidized, increases
The oxygen content in liquid is healed, is enhanced metabolism and microcirculation.For high fat of blood, hyperglycaemia, fatty liver, coronary heart disease, hypertension,
The treatment of Combined hepatitis A and B vaccine and the rehabilitation of the postoperative chemicotherapy patient of cancer have extraordinary booster action.Mulberry leaf can evacuate wind
Heat, inducing diaphoresis heat-clearing, nourishing Yin and promoting production of body fluid；Mulberry fruit energy nourishing yin and nourishing blood, qi-restoratives are moisturized；Cortex Mori energy removing heat from lung and relieving asthma, inducing diuresis for removing edema；Ramulus mori
Can clearing and activating the channels and collaterals, eliminating impediment and relieving pain；And the ash that mulberry tree burns till can be used for treating red eye, swell pain, glaucoma, body face water white mulberry wood-ashes
It is swollen, sitting and lying must not, the disease such as leucoderma, seborrheic dermatitis of the scalp, leprosy.
The invention also discloses a kind of preparation method for the herbal mixture dripping pill for treating diabetes B, comprise the following steps：
1) each component is weighed according to the parts by weight of each component；
2) above-mentioned traditional Chinese medicinal components are well mixed with water, the weight ratio of traditional Chinese medicinal components and water is 44:100；
3) flour is added into the mixture of Chinese medicine and water, added while stir, until stirring, obtain pill original
Material, added flour weight are 100 with Chinese medicine gross weight ratio:15；
4) the pill raw material is added into full-automatic pill, the Chinese kmedicine bolus of diameter 5mm sizes is made；
5) above-mentioned Chinese kmedicine bolus dry 6 hours at 70 DEG C, and use disinfection by ultraviolet light；
6) water-bindered pill is fitted into sterilized polybag, 60 every bag；
7) through microwave sterilization 3 minutes after sealing, you can the herbal mixture dripping pill for the diabetes B that obtains medical treatment.
Had the beneficial effect that using what the such scheme present invention obtained：A kind of diabetes B for the treatment of provided by the invention
Herbal mixture dripping pill, the selected natural Chinese traditional medicines material coptis, the wind-weed, mulberry leaf, pseudo-ginseng are as bulk composition, and formula is reasonable, each component
Between cooperate, act synergistically, softening vascular wall, expansion blood vessel, can significantly inhibit platelet aggregation, reduce blood viscousness
Degree, increase CBF, ensure islet cells amount of blood supply, make its function of bringing into normal play, the metabolism of balance glucose, so as to improve 2
The symptom of patients with type Ⅰ DM, and finally patient is broken away from pharmacological dependence.In addition, the herbal mixture dripping pill also can effectively improve hypertension
Symptom, have no side effect to human viscera organ, be higher than 85% through clinical test checking is efficient, being expected to, which turns into diabetes B, suffers from
The good medicine of person's rehabilitation.
Embodiment
The technical scheme in the embodiment of the present invention will be clearly and completely described below, it is clear that described implementation
Example is only the part of the embodiment of the present invention, rather than whole embodiments.It is common based on the embodiment in the present invention, this area
All other embodiment that technical staff is obtained under the premise of creative work is not made, belong to the model that the present invention protects
Enclose.
Type ii diabetes diagnostic criteria：The diabetes cause of disease published on DiabetesCare magazines with reference in July, 1997
Parting standard, all diagnostic criteria for meeting diabetes are learned, the one that insulin release test result meets following conditions diagnoses
For diabetes B.1. with relative insulin deficiency based on insulin resistance.2. insulin substantially lacks with insulin resistance.
1., 2. 3. not making a definite diagnosis person can not do.Chinese medical discrimination diagnostic criteria：Deficiency of both qi and yin or and heat symptom-complex：(1) primary symptom：It is lassitude hypodynamia, thirsty
Happiness drink, easily hungry more foods, urine are more.(2) secondary disease：Dysphoria in chestpalms-soles, spontaneous perspiration or the lazy speech of night sweat, shortness of breath, palpitaition, constipation.(3) tongue vein：Tongue
HongShaoJin(SIC) or tongue body fat big, arteries and veins are thin or count accurately.Above primary symptom is indispensable 1, adds time disease 2, is diagnosable with reference to tongue vein.
Embodiment 1
A kind of herbal mixture dripping pill for treating diabetes B, include the component of following parts by weight：1 part of coptis powder, wind-weed powder
2 parts, 1 part of Radix Notoginseng powder, 0.01 part of papaverine, 0.02 part of aminophylline, 1 part of mulberry leaf.
The preparation method of the present embodiment herbal mixture dripping pill, comprises the following steps：
1) each component is weighed according to the parts by weight of each component；
2) above-mentioned traditional Chinese medicinal components are well mixed with water, the weight ratio of traditional Chinese medicinal components and water is 44:100；
3) flour is added into the mixture of Chinese medicine and water, added while stir, until stirring, obtain pill original
Material, added flour weight are 100 with Chinese medicine gross weight ratio:15；
4) the pill raw material is added into full-automatic pill, the Chinese kmedicine bolus of diameter 5mm sizes is made；
5) above-mentioned Chinese kmedicine bolus dry 6 hours at 70 DEG C, and use disinfection by ultraviolet light；
6) water-bindered pill is fitted into sterilized polybag, 60 every bag；
7) through microwave sterilization 3 minutes after sealing, you can the herbal mixture dripping pill for the diabetes B that obtains medical treatment.
Embodiment 2
Difference with embodiment 1 is that the herbal mixture dripping pill of the treatment diabetes B in the present embodiment includes following weight
Measure the component of part：2 parts of coptis powder, 2.5 parts of wind-weed powder, 1.5 parts of Radix Notoginseng powder, 0.02 part of papaverine, 0.03 part of aminophylline, mulberry leaf 2
Part.
Embodiment 3
Difference with embodiment 1 is that the herbal mixture dripping pill of the treatment diabetes B in the present embodiment includes following weight
Measure the component of part：3 parts of coptis powder, 3 parts of wind-weed powder, 2 parts of Radix Notoginseng powder, 0.03 part of papaverine, 0.04 part of aminophylline, 3 parts of mulberry leaf.
Embodiment 4
Difference with embodiment 1 is that the herbal mixture dripping pill of the treatment diabetes B in the present embodiment includes following weight
Measure the component of part：2 parts of coptis powder, 2 parts of wind-weed powder, 2 parts of Radix Notoginseng powder, 0.02 part of papaverine, 0.02 part of aminophylline, 2 parts of mulberry leaf.
The clinical observation of embodiment 5
(1) clinical data：50 diabetes B patients.
(2) treatment method：The oral Chinese medicine dripping pills of the present invention for the treatment of group, once a bag, two times a day, postprandial oral, the course for the treatment of 2
Individual month or so.
(3) criterion of therapeutical effect is worked out with reference to new Chinese medicine treatment diabetes guideline of clinical investigations：
It is 1. effective：Symptom disappears substantially after treatment, fasting blood-glucose ＜ 7.2mmol/L (130mg/dl), postprandial 2 hours blood glucose
＜ 8.3mmol/L (150mg/dl), the quantitative ＜ 10.0g of twenty-four-hour urine sugar, or blood glucose twenty-four-hour urine sugar are quantified before relatively treating and declined
More than 30%.
It is 2. effective：Symptom is obviously improved after treatment, fasting blood-glucose ＜ 8.3mmol/L (150mg/dl), postprandial 2 hours blood glucose
＜ 10.0mmol/L (180mg/dl), the quantitative ＜ 25.0g of twenty-four-hour urine sugar, or blood glucose, twenty-four-hour urine sugar it is quantitative relatively treat it is front lower
Drop more than 10%.
It is 3. invalid：Symptom is not improved after treatment, and blood glucose, glucose in urine, which decline, is not up to above-mentioned standard.
(4) efficacy result：In 50, effective 39, effective 4, invalid 7, total effective rate 86%.
(5) therapeutic evaluation：After Case treatment 3 months, total treat is analyzed in terms of the leading indicator improvement such as patient symptom, blood glucose
Effect, as a result see the table below 1.
Fasting blood-glucose, 2h-plasma glucose, glycosylated hemoglobin compare before and after the Case treatment of table 1
From upper table 1, pretherapy and post-treatment fasting blood-glucose, 2h-plasma glucose, glycosylated hemoglobin are compared to there were significant differences.
(6) model case：
Mr. Wang, man, 50 years old, Arong Banner San Chahe people, because wound removes hospital admission, body is checked, as a result：Fasting blood-glucose
9.6mmol/L, blood routine leucocyte 17.1/L, blood glucose peak reach 13.04mmol/L.Diagnostic result：Right lower extremity is open
Wound, high blood pressure, diabetes B.The Chinese medicine dripping pills of the present invention are taken, it is once a bag, two times a day, postprandial oral, 1 month
Blood glucose is down to 8.2mmol/L by 9.6mmol/L afterwards, continues to take 1 month, stops the medicine of various diabetes more than 1 year, so far blood glucose
Normal level, participate in every work.
Gold so-and-so, female, 64 years old, the fresh smooth people of Tongliao City great Lin, headache and dizzy 10 years, thirsty one month, high blood pressure 10 years,
Fasting blood-glucose 8.0mmol/L, diagnostic result：High blood pressure, diabetes B.The Chinese medicine dripping pills of the present invention are taken, once a bag,
Two times a day, postprandial oral, headache and dizzy, thirsty symptom disappear after two first quarter moons, check that blood glucose is normal, after being discontinued 5 months, extremely
Modern non-diabetic symptom and blood glucose normal level, participate in various activities.
Bao, man, 57 years old, the left people in Tongliao City, drank more, more foods, diuresis, become thin without obvious inducement before 2 years, nearly one
Month exacerbation of symptoms, it is powerless, 80kg is down to from 90kg, blood glucose 17mmol/L is surveyed in locality, it is rear to check vein blood glucose 15.7mmol/L,
Diagnostic result：Diabetes B.First treated 4 days with melbine and novolin, blood glucose is down to 13.2mmol/L, and patient requests use
Insulin, glycemic control is left hospital in 8.0mmol/L, patient requests, after going home, taken in the present invention after insulin has been used 4 days
Medicine dripping pill, it is once a bag, two times a day, postprandial oral, it is discontinued after 2 months, blood glucose is normal at present, normal to participate in every work.
Complex clinical observes result, it can be deduced that to draw a conclusion：Composition involved in the present invention has good hypoglycemic
Effect, either fasting blood-glucose or postprandial blood sugar, improve significantly.It is and thirsty, hungry, tired, more for alleviating
The clinical symptoms such as urine are significantly improved effect, highly effective to the quality of life of improvement patient.
Embodiments of the invention are the foregoing is only, are not intended to limit the scope of the invention, it is every to utilize this hair
The equivalent structure or equivalent flow conversion that bright description is made, or directly or indirectly it is used in other related technology necks
Domain, it is included within the scope of the present invention.
Claims (5)
1. a kind of herbal mixture dripping pill for treating diabetes B, it is characterised in that include the component of following parts by weight：Coptis powder
1-3 parts, wind-weed powder 2-3 parts, Radix Notoginseng powder 1-2 parts, 0.01~0.03 part of papaverine, 0.02~0.04 part of aminophylline, mulberry leaf 1-3
Part.
2. a kind of herbal mixture dripping pill for treating diabetes B according to claim 1, it is characterised in that including as follows
The component of parts by weight：1 part of coptis powder, 2 parts of wind-weed powder, 1 part of Radix Notoginseng powder, 0.01 part of papaverine, 0.02 part of aminophylline, 1 part of mulberry leaf.
3. a kind of herbal mixture dripping pill for treating diabetes B according to claim 1, it is characterised in that including as follows
The component of parts by weight：2 parts of coptis powder, 2.5 parts of wind-weed powder, 1.5 parts of Radix Notoginseng powder, 0.02 part of papaverine, 0.03 part of aminophylline, mulberry leaf
2 parts.
4. a kind of herbal mixture dripping pill for treating diabetes B according to claim 1, it is characterised in that including as follows
The component of parts by weight：3 parts of coptis powder, 3 parts of wind-weed powder, 2 parts of Radix Notoginseng powder, 0.03 part of papaverine, 0.04 part of aminophylline, 3 parts of mulberry leaf.
A kind of 5. preparation method of the herbal mixture dripping pill for the treatment of diabetes B as claimed in claim 1, it is characterised in that
Comprise the following steps：
1) each component is weighed according to the parts by weight of each component；
2) above-mentioned traditional Chinese medicinal components are well mixed with water, the weight ratio of traditional Chinese medicinal components and water is 44:100；
3) flour is added into the mixture of Chinese medicine and water, added while stir, until stirring, obtain pill raw material, institute
It is 100 to add flour weight and Chinese medicine gross weight ratio:15；
4) the pill raw material is added into full-automatic pill, the Chinese kmedicine bolus of diameter 5mm sizes is made；
5) above-mentioned Chinese kmedicine bolus dry 6 hours at 70 DEG C, and use disinfection by ultraviolet light；
6) water-bindered pill is fitted into sterilized polybag, 60 every bag；
7) through microwave sterilization 3 minutes after sealing, you can the herbal mixture dripping pill for the diabetes B that obtains medical treatment.
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| CN201710939632.8A CN107638502A (en) | 2017-10-11 | 2017-10-11 | A kind of herbal mixture dripping pill for treating diabetes B and preparation method thereof |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101884723A (en) * | 2010-07-29 | 2010-11-17 | 北京普瑞博思投资有限公司 | Anemarrhena and goldthread composition preparation used for treating diabetes and preparation method thereof |
-
2017
- 2017-10-11 CN CN201710939632.8A patent/CN107638502A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101884723A (en) * | 2010-07-29 | 2010-11-17 | 北京普瑞博思投资有限公司 | Anemarrhena and goldthread composition preparation used for treating diabetes and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| A.M. PEREIRA ARIAS，ET AL.: "Aminophylline Stimulates Insulin Secretion in Patients With Type 2 Diabetes Mellitus", 《METABOLISM》 * |
| 林兰: "《内分泌代谢病中西医结合研究 临床与基础》", 31 October 2010, 军事医学科学出版社 * |
| 梅全喜: "《现代中药药理与临床应用手册》", 31 October 2016, 中国中医药出版社 * |
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