CN107260963A - The method that treatment hypertension drug is prepared as main material using dendrobium candidum and radish seed - Google Patents
The method that treatment hypertension drug is prepared as main material using dendrobium candidum and radish seed Download PDFInfo
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Abstract
The present invention relates to pharmaceutical formulation techniques, it is desirable to provide a kind of method that treatment hypertension drug is prepared as main material using dendrobium candidum and radish seed.Including：Mixed after stir-baked SEMEN RAPHANI, the tuber of dwarf lilyturf and the root of herbaceous peony are ground respectively, heating water is extracted, concentration, obtain water and extract concentrate；Dendrobium candidum is ground to it is powdered, add water extract concentrate in；Add auxiliary material shaping.Or four kinds of medicinal materials are ground to powdered, then carry out alcohol extracting：Plus 60 DEG C of 75% ethanol of 5 times of crude drug amounts is extracted 24 hours, is extracted 2 times altogether, reclaims ethanol；After alcohol extracting, residue carries out water extraction process again, concentration, merges the extract solution that alcohol extracting and water are extracted.Add auxiliary material shaping.Medicine produced by the present invention is applied to the high blood pressure of yin deficiency syndrome or syndrome of hyperactivity of yang due to yin deficiency, and with having no peace of mind, the treatment of insomniac；Or Western medicine antihypertensive drug therapy is shared, reduce Western medicine antihypertensive drugs usage amount.Mild hypertension is also applied for simultaneously, or the health care of normal hyperpietic partially is used.
Description
Technical field
The present invention relates to pharmaceutical formulation techniques, more particularly to treatment hypertension is prepared using dendrobium candidum and radish seed as main material
The method of medicine and application.
Background technology
High blood pressure is clinical common high morbidity, has to important organs such as the heart, brain, kidneys and seriously endangers.China 2013
Degree《Chinese cardiovascular disease report》Estimation, whole nation hyperpietic is about 2.7 hundred million at present.2012nd, 2013《Chinese cardiovascular disease
Report》Display：China's angiocardiopathy case fatality rate is 44.1%, is occupied the first in dead spectrum of disease.And hypertension is cardiovascular and cerebrovascular
The primary cause of disease of disease.Epidemiological survey result shows that China causes cardiovascular and cerebrovascular disease case fatality rate to rise year by year because of hypertension, just
For cerebral apoplexy, the people of cerebral apoplexy more than 160 ten thousand newly sends out every year in China, adds up people of survivor 6,000,000 or so, wherein more than 75% loses
Labour, 45% severe disables, and can't take care of oneself.
Western medicine high blood pressure still lacks adjustment constitution and can adjust the medicine of blood pressure (decompression).The decompression of modern medicine
Treatment is symptomatic treatment.Conventional depressor includes calcium ion channel blocker (CCB), angiotensin converting enzyme suppression at present
5 kinds of preparation (ACEI), hypertensinⅡreceptorretarder (ARB), diuretics and beta-blocker, high blood can not be still prevented completely
The progress of pressure disease and its secondary affection.Most of hyperpietics need 2 kinds or depressor of more than two kinds can reach target
Blood pressure, or be difficult to reach target blood pressure, most of patients needs lifelong medication, and because of long-term therapy medication, curative effect of medication gradually drops
It is low, toxic side effect is produced, also has these problems with life-time dilatation more to protrude.Current hypertension therapeutic still compels to be essential
Want new more perfect medicine.
Current herbal treatment method, which is used for hypertension, some superiority, but there is also wretched insufficiency.Although herbal treatment
Hypertension, pressure decay rate and amplitude do not have Western medicine decompression fast, but more stable persistently with curative effect, blood pressure rises amplitude after drug withdrawal
It is small, the advantage that the simultaneously favourable overall constitution of control blood pressure is improved.Or conditioning reduces blood pressure simultaneously, moreover it is possible to reduce blood fat etc., have
Have the advantages that to adjust constitution, the later many-sided pathological index improvement of constitution improved, with certain application value.But remain
The reduction of recent blood pressure is not obvious enough after medication, and medicine taste number is too many and checks and balance or counteract effect, medicament composing prescription, carries
Take, curative effect does not reach requirement without system optimization for preparation process etc., it is difficult to which there is actual application value in clinic.
The content of the invention
The technical problem to be solved in the present invention is to overcome deficiency of the prior art there is provided one kind with dendrobium candidum and Lay
Fu is method and the application that main material prepares treatment hypertension drug.
To solve technical problem, solution of the invention is：
A kind of method that utilization dendrobium candidum prepares treatment hypertension drug with radish seed is provided, comprised the steps：
(1) 2015 editions are pressed《Chinese Pharmacopoeia》In requirement, take 2.5-15 parts of dendrobium candidum, 2.5-60 parts of stir-baked SEMEN RAPHANI, wheat
2.5-15 parts of winter 2.5-15 part, the root of herbaceous peony, the number is parts by weight；
(2) mixed after grinding stir-baked SEMEN RAPHANI, the tuber of dwarf lilyturf and the root of herbaceous peony respectively, heating water is extracted, concentration, obtain water and extract concentration
Liquid；
(3) dendrobium candidum is ground to it is powdered, add water extract concentrate in；Then according to pharmacy Conventional processing methods
Auxiliary material is added, Chinese medicinal tablet, particle, pill or capsule is made, the medicine for treating hypertension is obtained.
It is to obtain preparation invention further provides the application method of the hypertension drug prepared in preceding method
Chinese medicinal tablet, particle, pill or the capsule obtained is with oral way medication, and adult is per consumption per day equivalent to crude drug amount 10g to 105g.
It is by institute present invention also offers application of the hypertension drug prepared in preceding method as health food
State Chinese medicinal tablet, particle, pill or capsule to use with oral way as health food, adult is per consumption per day equivalent to crude drug amount
10g to 105g.
Present invention also offers the method that another utilization dendrobium candidum and radish seed prepare treatment hypertension drug, including
Following step：
(1) 2015 editions are pressed《Chinese Pharmacopoeia》In requirement, take 5-30 parts of dendrobium candidum, 5-120 parts of stir-baked SEMEN RAPHANI, tuber of dwarf lilyturf 5-
30 parts, 5-30 parts of the root of herbaceous peony, the number are parts by weight；
(2) four kinds of medicinal materials are ground to powdered, then carry out alcohol extracting：Plus 75% ethanol of 5 times of crude drug amounts, 60 DEG C of extractions
24 hours, extract 2 times altogether, reclaim ethanol；After alcohol extracting, residue carries out water extraction process again, concentration, merges what alcohol extracting and water were extracted
Extract solution.
(3) auxiliary material is added according to pharmacy Conventional processing methods, Chinese medicinal tablet, particle, pill or capsule is made, is used for
Treat the medicine of hypertension.
In the present invention, it is gradient-heated water extraction twice that the water, which is extracted,；Temperature is extracted in control when wherein first time water is extracted
Spend for 100 DEG C, second of water controls Extracting temperature to be 121 DEG C when extracting, merge extract solution twice.
It is to obtain preparation invention further provides the application method of the hypertension drug prepared in preceding method
Chinese medicinal tablet, particle, pill or the capsule obtained is with oral way medication, and adult is per consumption per day equivalent to crude drug amount 10g to 150g.
Present invention also offers application of the hypertension drug prepared in preceding method as health food, its feature
It is, is to use the Chinese medicinal tablet, particle, pill or capsule with oral way as health food, adult is per consumption per day
Equivalent to crude drug amount 10g to 150g.
The realization principle of the present invention：
High blood pressure thinks to belong to hyperactivity of yang due to yin deficiency greatly that existing deficiency of Yin one side has yang-energy to rise too again in theory of traditional Chinese medical science
Cross, i.e., mechanism of qi rises the not enough one side of sedimentation of having a surplus.Meanwhile, most of patients is also with phlegm wet, fat (high fat of blood), and the mind is not
Rather, insomnia etc..Nourishing and suppressing Yang, lowering the adverse-rising QI to resolve phlegm, clearing away the heart fire and tranquillizing is its primary treatment direction.
According to traditional Chinese medical theory and practice, reference《Pharmacopoeia of People's Republic of China》Version is recorded within 2015：Dendrobium candidum
Performance is reinforcing stomach reg fluid, nourishing Yin and clearing heat.Available for pyreticosis Tianjin wound, dry polydipsia, deficiency of stomach-Yin, deficiency of food is retched, and abnormal heat is not after being ill
Move back, fire excess from yin deficiency, hectic fever due to yin labor heat, mesh is secretly failed to understand, muscles and bones impotence.Also have in the prior art for hypertension therapeutic, but because of its work
It is slow without sizable application with working.The performance of stir-baked SEMEN RAPHANI is helps digestion de-swelling, lowering the adverse-rising QI to resolve phlegm, available for retention of food and drink,
Abdominal distention, constipation, stagnate rush down dysentery, and phlegm, which is stopped up, breathes with cough.But, two kinds of Chinese medicines are in the application for the treatment of hypertension：
Only dendrobium candidum nourishing Yin and clearing heat, without guiding the descending effect of mechanism of qi, antihypertensive effect is limited to, only radish seed sending down abnormally ascending
Resolving sputum, without enriching yin with checking exuberance of yang, antihypertensive effect is also limited to.Generally consider：Radish seed is promoting the circulation of qi treatment for relieving indigestion and constipation medicine, typically not
Used simultaneously with traditional tonic medicine, if promoting the circulation of qi treatment for relieving indigestion and constipation medicine prolonged application as radish seed, also consume excessive misgivings, carried on a shoulder pole
The heart hinders constitution to improve and hypertension rehabilitation.Present invention initiative property both are used cooperatively, with nourishing and suppressing Yang, while guiding gas
Machine is descending, and is formulated in proper proportions, and appropriate preparation technology, its antihypertensive effect is increased substantially, and breaches conventional idea,
Achieve unexpected curative effect.
According to traditional Chinese medical theory and practice, reference《Pharmacopoeia of People's Republic of China》Version is recorded within 2015：The performance of the tuber of dwarf lilyturf
For nourishing Yin and promoting production of body fluid, moistening lung clears away heart-fire, for dryness of the lung dry cough, cough for deficiency of Yin consumptive disease, larynx numbness pharyngalgia, injury thirst, Heat Diabetes, vexed mistake
Sleep, dry constipation of intestines.The performance of the root of herbaceous peony is nourishing blood for regulating menstruation, astringing YIN to stop sweating, soft liver analgesic, suppressing liver-YANG.For blood deficiency chlorosis, menstruation
It is uncomfortable, spontaneous perspiration, night sweat, hypochondriac pain, stomachache, four limbs contraction pain, dizziness of having a headache.Application of the two kinds of Chinese medicines in treatment hypertension
It is：The tuber of dwarf lilyturf is not individually used for the reported literature of hypertension treatment, and the root of herbaceous peony is individually used for reducing blood pressure also rare reported literature,
The root of herbaceous peony can be used for nourishing blood and liver, treat the illnesss such as the dizziness of having a headache of blood deficiency and sthenic liver-energy, this height of tradition application indirectly with the modern times
Blood pressure diseases treatment has certain association.Present invention initiative property both are coupled in dendrobium candidum, stir-baked SEMEN RAPHANI formula, strengthened
Nourishing Yin and clearing heat is acted on, and adds nourishing blood and liver and clearing away the heart fire and tranquillizing effect.Four kinds of Chinese medicine complete square compatibilities are closed, and both nourishing and suppressing Yang and have been guided
Mechanism of qi is descending to reduce blood pressure, and nourishing blood and liver and clearing away the heart fire and tranquillizing are formed benign cycle, are conducive to the heart with sharp blood pressure stabilization
God's not peaceful, blood pressure rehabilitation of insomniac.
The present invention innovatively proposes two sets of schemes for preparing treatment hypertension drug, and gained medicine is applied to the deficiency of Yin
The high blood pressure of card or syndrome of hyperactivity of yang due to yin deficiency, and with having no peace of mind, the treatment of insomniac；Or share Western medicine antihypertensive drugs and control
Treat, reduce Western medicine antihypertensive drugs usage amount.Meanwhile, two kinds of medicines are also applied for mild hypertension, or normal higher blood pressure
The health care of person is used.What is more important, efficacy of antihypertensive treatment is not ideal enough generally in terms of curative effect for Traditional Chinese Medical on Treating Hypertension, is depressured
The problem of imitating speed not fast enough, and be not easy to stablize with the fluctuation of blood pressure for the hyperpietic for having no peace of mind, having a sleepless night, and this
Medicine in invention results in the curative effect close with Western medicine depressor, and is acted on nourishing blood and liver and clearing away the heart fire and tranquillizing.This is
Highly significant, the breakthrough imagination unexpected technique effect.
The difference of two schemes is：Processing side is carried and (includes two subgradient water extractions) using four kinds of Chinese medicines are carried out with alcohol water two
The injection volume of its final gained of case is smaller, and larger crude drug amount can be used to improve curative effect, conveniently taken.But, using only
It is then relative to radish seed, the tuber of dwarf lilyturf and root of herbaceous peony water extraction processing scheme (dendrobium candidum levigation is used as medicine) to save medicinal material.
It is pointed out that in view of the homology of Chinese medicine and health products, in most cases, Chinese medicine and health food are only
It is the difference that there is national management classification, its substantive content is basic or even identical.And heretofore described product is fallen within
Such case, can both be used to treat hypertension as Chinese medicine, can also be used as mild hypertension or normal hyperpietic partially
Daily health caring is used, and the application method in the case of two kinds is identical.
Compared with prior art, the beneficial effects of the present invention are：
1st, dendrobium candidum coordinates stir-baked SEMEN RAPHANI, the tuber of dwarf lilyturf, the root of herbaceous peony " to treat both principal and secondary aspect of disease " hypertension curative effect protrusion：Dendrobium candidum enriching yin
It is the method for " the effecting a permanent cure " of hyperactivity of yang due to yin deficiency constitution with checking exuberance of yang；Stir-baked SEMEN RAPHANI sending down abnormally ascending, guiding qi and blood is descending, and energy resolving sputum is wet, is
The method of " treating both principal and secondary aspect of disease ".Two medicines are shared, and can comparatively fast obtain the curative effect that reduces blood pressure, but in obtaining preferably, it is at a specified future date stable
Blood pressure, adjustment and the constitution for recovering up and down balance system.The tuber of dwarf lilyturf, root of herbaceous peony antitoxic heart-soothing and sedative are equipped with again, and Yanggan liver recovers to rise with sharp mechanism of qi
Drop balance.The formula results in the unexpected curative effect close with Western medicine depressor.
2nd, it is unaffected to normal arterial pressure to the selective corrective action of hyperpietic：To reducing blood pressure for hypertension
Effect, but effect is not reduced to normal arterial pressure.Hypertension will not also be reduced to normal following.This is also relative to most west
The advantage of medicine depressor.
3rd, in extraction scheme of the invention, tablet, pill, capsule is made using herb powder and are conducive to playing lasting and steady
Fixed drug effect：(1) hypertension therapeutic needs medicine to play persistently and stable drug effect, and Western medicine depressor uses slow release formulation, this
Invention uses fine medicinal material powder that tablet, pill, capsule is made to play " ball person delays " described in the traditional Chinese medical science, so that medicine progressively dissolution
Play a role, play persistently and stable drug effect；(2) dendrobium candidum levigation is given birth to (being different from " decocting long " to use)：Also have preferably
" heat-clearing ", " reducing internal heat " effect, be conducive to the rapid decrease of blood pressure；(3) dendrobium candidum is that valuable medicinal needs to make full use of：This
Inventive technique scheme has taken into full account the utilization of dendrobium candidum valuable medicinal, reduces the waste caused by extracting not exclusively, simultaneously
Also destruction of the heating extraction process to fractions is reduced, to improve curative effect, valuable medicinal is saved.
4th, in alcohol extracting+water extraction scheme of the invention, (1) comprehensive extraction method can be than conventional water extraction reduction component damages
Improve validity：All medicinal materials are ground, and contact surface is extracted in increase；First ethanol is extracted, it is ensured that alcohol-soluble material is in lower temperature
Under the conditions of dissolution, water is extracted again after alcohol extracting, when water is extracted alcohol easy stripping material not wherein, heating temperature when water is extracted
Degree does not interfere with the easy stripping material of alcohol, favorably improves curative effect.
5th, 2 subgradient heating extractions are used when water is extracted：It is when first time water extracts 100 DEG C, water-soluble substances is conventional
Propose, and avoid excessive temperature to the adverse effect of composition；When second of water extracts 121 DEG C, be conducive to proposing higher temperature resistant
And it is difficult to the material of dissolution, such as long chain polysaccharides, molecular weight of degrading favorably puts forward and absorbed.
6th, the present invention both nourishing and suppressing Yang and had guided mechanism of qi descending to reduce blood pressure, and nourishing blood and liver and clearing away the heart fire and tranquillizing are with sharp blood
Pressure is stable, forms benign cycle, is conducive to having no peace of mind, the blood pressure rehabilitation of insomniac.
Embodiment
Embodiment 1
2.5 parts of dendrobium candidum, 2.5 parts of stir-baked SEMEN RAPHANI, 2.5 parts of the tuber of dwarf lilyturf, 2.5 parts of the root of herbaceous peony：
Take and meet 2015 editions《Chinese Pharmacopoeia》Dendrobium candidum 250g, stir-baked SEMEN RAPHANI 250g, tuber of dwarf lilyturf 250g, root of herbaceous peony 250g.
Stir-baked SEMEN RAPHANI, the tuber of dwarf lilyturf, the root of herbaceous peony are ground, and add water 12 times and measure heating extraction 2 hours, extract 2 times, are concentrated to 500g.By dendrobium candidum
The finely ground powder of medicinal material, plus foregoing stir-baked SEMEN RAPHANI, the tuber of dwarf lilyturf, root of herbaceous peony water extraction concentrate, stir, softwood are made, then ball is made.70
Degree drying.For the sample of embodiment 1.Orally, it is grown up per consumption per day equivalent to crude drug amount 10g (can be greatly to 30g).
Embodiment 2
10 parts of dendrobium candidum, 20 parts of stir-baked SEMEN RAPHANI, 10 parts of the tuber of dwarf lilyturf, 10 parts of the root of herbaceous peony：
Take and meet 2015 editions《Chinese Pharmacopoeia》Dendrobium candidum 200g, stir-baked SEMEN RAPHANI 400g, tuber of dwarf lilyturf 200g, root of herbaceous peony 200g.
Stir-baked SEMEN RAPHANI, the tuber of dwarf lilyturf, the root of herbaceous peony are ground, and add water 12 times and measure heating extraction 2 hours, extract 2 times, are concentrated to 500g.By dendrobium candidum
The finely ground powder of medicinal material, plus foregoing stir-baked SEMEN RAPHANI, the tuber of dwarf lilyturf, root of herbaceous peony water extraction concentrate, stir, softwood are made, then ball is made.70
Degree drying.For the sample of embodiment 2.Orally, it is grown up per consumption per day equivalent to crude drug amount 50g (can be as small as 10g).
Embodiment 3
15 parts of dendrobium candidum, 60 parts of stir-baked SEMEN RAPHANI, 15 parts of the tuber of dwarf lilyturf, 15 parts of the root of herbaceous peony：
Take and meet 2015 editions《Chinese Pharmacopoeia》Dendrobium candidum 142.86g, stir-baked SEMEN RAPHANI 571.43g, tuber of dwarf lilyturf 142.86g,
Root of herbaceous peony 142.86g.Stir-baked SEMEN RAPHANI, the tuber of dwarf lilyturf, the root of herbaceous peony are ground, and add water 12 times and measure heating extraction 2 hours, extract 2 times, are concentrated to
500g.By the finely ground powder of dendrobium candidum medicinal material, plus foregoing stir-baked SEMEN RAPHANI, the tuber of dwarf lilyturf, root of herbaceous peony water extraction concentrate, stir, be made
Softwood, then ball is made.70 degree of drying.For the sample of embodiment 3.Orally, being grown up (can be with small equivalent to crude drug amount 105g per consumption per day
To 10g).
Embodiment 4
5 parts of dendrobium candidum, 5 parts of stir-baked SEMEN RAPHANI, 5 parts of the tuber of dwarf lilyturf, 5 parts of the root of herbaceous peony：
Take and meet 2015 editions《Chinese Pharmacopoeia》Dendrobium candidum 250g, stir-baked SEMEN RAPHANI 250g, tuber of dwarf lilyturf 250g, root of herbaceous peony 250g,
Grind respectively, plus 60 DEG C of 75% ethanol of 5 times of total crude drug amounts is extracted 24 hours, is extracted 2 times, water is extracted residue again after alcohol extracting.
2 subgradient heating extractions are used when water is extracted：First time water is extracted：Add up 30 times of water of crude drug amount, 100 DEG C
Extract 2 hours；Second of water is extracted：20 times of water of crude drug amount is added up, 121 DEG C are extracted 2 hours.Water extract merges concentration.
Alcohol extracting is extracted after concentration respectively with water, merges extract, according to pharmacy routine addition suitable excipients, in being fabricated to
Pill agent.For the sample of embodiment 4.Orally, it is grown up per consumption per day equivalent to crude drug amount 20g (can be greatly to 60g).
Embodiment 5
20 parts of dendrobium candidum, 40 parts of stir-baked SEMEN RAPHANI, 20 parts of the tuber of dwarf lilyturf, 20 parts of the root of herbaceous peony：
Take and meet 2015 editions《Chinese Pharmacopoeia》Dendrobium candidum 200g, stir-baked SEMEN RAPHANI 400g, tuber of dwarf lilyturf 200g, root of herbaceous peony 200g.
Grind respectively, plus 60 DEG C of 75% ethanol of 5 times of total crude drug amounts is extracted 24 hours, is extracted 2 times, water is extracted residue again after alcohol extracting.
2 subgradient heating extractions are used when water is extracted：First time water is extracted：Add up 30 times of water of crude drug amount, 100 DEG C
Extract 2 hours；Second of water is extracted：20 times of water of crude drug amount is added up, 121 DEG C are extracted 2 hours.Water extract merges concentration.
Alcohol extracting is extracted after concentration respectively with water, merges extract, according to pharmacy routine addition suitable excipients, in being fabricated to
Pill agent.For the sample of embodiment 5.Orally, it is grown up per consumption per day equivalent to crude drug amount 100g (can be as small as 20g).
Embodiment 6
30 parts of dendrobium candidum, 120 parts of stir-baked SEMEN RAPHANI, 30 parts of the tuber of dwarf lilyturf, 30 parts of the root of herbaceous peony：
Take and meet 2015 editions《Chinese Pharmacopoeia》Dendrobium candidum 142.86g, stir-baked SEMEN RAPHANI 571.43g, tuber of dwarf lilyturf 142.86g,
Root of herbaceous peony 142.86g.Grind respectively, plus 60 DEG C of 75% ethanol of 5 times of total crude drug amounts is extracted 24 hours, is extracted 2 times, residue after alcohol extracting
Water is extracted again.
2 subgradient heating extractions are used when water is extracted：First time water is extracted：Add up 30 times of water of crude drug amount, 100 DEG C
Extract 2 hours；Second of water is extracted：20 times of water of crude drug amount is added up, 121 DEG C are extracted 2 hours.Water extract merges concentration.
Alcohol extracting is extracted after concentration respectively with water, merges extract, according to pharmacy routine addition suitable excipients, in being fabricated to
Pill agent.For the sample of embodiment 6.Orally, it is grown up per consumption per day equivalent to crude drug amount 210g (can be as small as 20g)
Experiment 1
Experimental study of the sample of embodiment 1 to genetic hypertension rat (SHR) antihypertensive effect
【Experiment material】
Rat：10 week old genetic hypertension rats (SHR), normal control selects Wistar rats.
Test Chinese medicine：The test specimen of embodiment 1, uses hot water dissolving before use.
Western medicine decompression control medicine：Irbesartan Tablets (An Bowei), 150mg/ pieces, lot number：6A208, matches Norfin, Inc.
Rat blood pressure is measured：The noninvasive arteria caudalis survey meter of blood pressure of BP-98A types, Japanese Ruan Rong Co., Ltd..
【Experimental method】
GP TH：Measurement blood pressure and body weight after whole rat adaptability are raised one week, are grouped.By SHR rats point
For heavy dose group crude drug amount 3.0g/Kg body weight, middle dose group crude drug amount 2.0g/Kg body weight, small dose group crude drug amount 1.0g/Kg bodies
Weight, gastric infusion, hypertension model control group gavage normal saline, Irbesartan control group gavage Irbesartan 15mg/
Kg body weight, Normal group gavage normal saline.Every group 10, treat 8 weeks.Withdrawal observation blood pressure 1 week.
Blood pressure measurement：By 38 DEG C of preheating 5-10min of rat, to avoid the less survey of rat tailses CBF from can't get a blood pressure reading.
In the case where rat regains consciousness rest state, the continuous average for measuring 3 times, 3 times is used as the mouse pressure value.1st week, 1 blood of measurement in the 2nd week
Pressure, 1 blood pressure of measurement in every 2 weeks, was measured in 2 hours after administration.
【Experimental result】
Blood pressure data1, table 2 is shown in Table, when treating 8 weeks, 181.7 ± 8.76/140.3 of heavy dose group blood pressure ±
6.76mmHg, middle dose group blood pressure 192.2 ± 6.51/148.1 ± 4.79mmHg, small dose group blood pressure 198.5 ± 6.51/
152.6 ± 5.01mmHg, substantially less than 214.4 ± 8.75/164.5 of model group blood pressure ± 5.49mmHg (P<0.05).Western medicine
The Irbesartan control group blood pressure rises after drug withdrawal that reduce blood pressure are also fast.Heavy dose group antihypertensive effect is compareed with Western medicine Irbesartan
The overall efficacy of antihypertensive treatment of group is close, but heavy dose of group antihypertensive effect is more stable and lasting after drug withdrawal.
Heavy dose of group has significant curative effect when treating 1 week.After drug withdrawal in terms of blood pressure rises, large, medium and small dosage group is more western
Medicine Irbesartan control group is slow, and Chinese medicine reduces blood pressure more stable lasting.
The suitable adult human dose of rat dosage correspondence used in this experiment：
The suitable adult human dose of heavy dose group correspondence is about crude drug amount 30g/ days；
The suitable adult human dose of middle dose group correspondence is about crude drug amount 20g/ days；
The suitable adult human dose of small dose group correspondence is about crude drug amount 10g/ days；
The suitable adult human dose of Irbesartan control group correspondence is about Irbesartan 150mg/ days.
【Conclusion】
The sample of embodiment 1 heavy dose (crude drug amount 3.0g/Kg body weight), middle dosage (crude drug amount 2.0g/Kg body weight), low dose
(crude drug amount 1.0g/Kg body weight) has antihypertensive effect to SHR.Heavy dose of group (crude drug amount 3.0g/Kg body weight) totality efficacy of antihypertensive treatment
It is close with Irbesartan (15mg/Kg body weight), but blood pressure is more stable and lasting after drug withdrawal.
Experiment 1：The sample of 1 embodiment of table 1 to SHR rat systolic pressures influence (Unit：mmHg)
Note：Compared △ P with model group<0.05▲P<0.01；Heavy dose group is compared P with husky smooth control group<0.05■P<
0.01。
Experiment 1：The sample of 2 embodiment of table 1 to SHR rat diastolic pressures influence (Unit：mmHg)
Note：Compared △ P with model group<0.05▲P<0.01；Heavy dose group is compared P with husky smooth control group<0.05■P<
0.01。
Experiment 2
The sample of embodiment 3 and experimental study of the sample of embodiment 6 to genetic hypertension rat (SHR) antihypertensive effect
【Experiment material】
Rat：18 week old genetic hypertension rats (SHR), normal control selects Wistar rats.
Test Chinese medicine：
The test specimen of embodiment 3, uses hot water dissolving before use.
The test specimen of embodiment 6, uses hot water dissolving before use.
Western medicine decompression control medicine：Irbesartan Tablets (An Bowei), 150mg/ pieces, lot number：6A208, matches Norfin, Inc.
Rat blood pressure is measured：The noninvasive arteria caudalis survey meter of blood pressure of BP-98A types, Japanese Ruan Rong Co., Ltd..
【Experimental method】
GP TH：Measurement blood pressure and body weight after whole rat adaptability are raised one week, are grouped.By SHR rats point
For the heavy dose of group crude drug amount 21g/Kg body weight of embodiment 6, the small dose group crude drug amount 10.5g/Kg body weight of embodiment 6, the sample of embodiment 3
Product group crude drug amount 10.5g/Kg body weight, the normal administration sample of embodiment 6 (heavy dose) group crude drug amount 21g/Kg body weight, gavage is given
Medicine.Hypertension model control group gavage normal saline, Irbesartan control group gavage Irbesartan 15mg/Kg body weight, just
Normal control group gavage normal saline.Every group 10, treat 2 weeks.
Blood pressure measurement：By 38 DEG C of preheating 5-10min of rat, to avoid the less survey of rat tailses CBF from can't get a blood pressure reading.
In the case where rat regains consciousness rest state, the continuous average for measuring 3 times, 3 times is used as the mouse pressure value.Weekly measure 1 blood pressure, in
Measure within 2 hours after medicine.
【Experimental result】
Blood pressure data1, table 2 is shown in Table, when treating 2 weeks, the sample of embodiment 6 heavy dose group blood pressure 169.8 ±
4.86/132.1 ± 7.54mmHg, the sample small dose group blood pressure 189.8 ± 6.74/141.3 ± 5.31mmHg of embodiment 6, show
Write and be less than model group blood pressure 212.9 ± 6.72/158.8 ± 5.37mmHg (P<0.01).The sample of embodiment 6 heavy dose group blood pressure ratio
Western medicine Irbesartan 183.8 ± 5.31/138.7 of control group blood pressure ± 8.87mmHg are low, also than the sample controls group blood pressure of embodiment 3
183.7 ± 6.57/139.9 ± 5.69mmHg are low.
The normal administration sample of embodiment 6 (heavy dose) group blood pressure has no decline, illustrates the sample of embodiment 6 to the big of hypertension
The mouse effect of reducing blood pressure, but effect is not reduced to normal arterial pressure, do not find to drop hypertension in the case of heavy dose yet
It is low to arrive normal following.This is also relative to the advantage of most Western medicine depressor.
The suitable adult human dose of rat dosage correspondence used in this experiment：
The suitable adult human dose of the sample of embodiment 6 heavy dose group correspondence is about crude drug amount 210g/ days；
The suitable adult human dose of the sample small dose group of embodiment 6 correspondence is about crude drug amount 105g/ days；
The suitable adult human dose of the sample sets of embodiment 3 correspondence is about crude drug amount 105g/ days；
The suitable adult human dose of the normal administration sample of embodiment 6 (heavy dose) group correspondence is about crude drug amount 210g/ days；
The suitable adult human dose of Irbesartan control group correspondence is about Irbesartan 150mg/ days.
【Conclusion】
The sample of embodiment 6 heavy dose (crude drug amount 21g/Kg body weight), low dose of (crude drug amount 10.5g/Kg body weight) are equal to SHR
There is antihypertensive effect.Heavy dose of Amplitude of Hypotensive is bigger than Irbesartan (15mg/Kg body weight).
The Amplitude of Hypotensive of the sample of embodiment 3 (crude drug amount 10.5g/Kg body weight) and the low dose of (crude drug amount of the sample of embodiment 3
10.5g/Kg body weight) it is close, it is low dose of slightly larger than the sample of embodiment 3.
The sample of embodiment 6 does not reduce effect to normal arterial pressure to the effect of reducing blood pressure of the rat of hypertension, does not have yet
Being found in the case of heavy dose makes hypertension be reduced to below normal.This is also relative to the advantage of most Western medicine depressor.
Experiment 2：The sample of 1 embodiment of table 6 and the sample of embodiment 3 to SHR rat systolic pressures influence (Unit：
mmHg)
Note：Compared △ P with model group<0.05▲P<0.01；Heavy dose group is compared P with husky smooth control group<0.05■P<
0.01。
Experiment 2：The sample of 2 embodiment of table 6 and the sample of embodiment 3 to SHR rat diastolic pressures influence (Unit：
mmHg)
Note：Compared △ P with model group<0.05▲P<0.01；Heavy dose group is compared P with husky smooth control group<0.05■P<
0.01。
Experiment 3
Dendrobium candidum shares the experimental study to genetic hypertension rat (SHR) antihypertensive effect with stir-baked SEMEN RAPHANI
【Experiment material】
Rat：Genetic hypertension rat (SHR), normal control selects Wistar rats.
Test Chinese medicine：With reference to the sample of embodiment 3, this laboratory sample is made：
Dendrobium candidum sample：Take and meet 2015 editions《Chinese Pharmacopoeia》Dendrobium candidum 200g, finely ground powder uses hot water before use
Dissolving.
Stir-baked SEMEN RAPHANI sample：Take and meet 2015 editions《Chinese Pharmacopoeia》Stir-baked SEMEN RAPHANI 800g, grind, add water 6 times and measure heating
Extract 2 hours, extract 2 times, be concentrated to 400ml, it is standby.
Western medicine decompression control medicine：Irbesartan Tablets (An Bowei), 150mg/ pieces, lot number：6A208, matches Norfin, Inc.
Rat blood pressure is measured：The noninvasive arteria caudalis survey meter of blood pressure of BP-98A types, Japanese Ruan Rong Co., Ltd..
【Experimental method】
GP TH：Measurement blood pressure and body weight after whole rat adaptability are raised one week, are grouped.By SHR rats point
For dendrobium candidum group crude drug amount 1.5g/Kg body weight, stir-baked SEMEN RAPHANI group crude drug amount 6.0g/Kg body weight, combination group dendrobium candidum crude drug
Measure 1.5g/Kg body weight and stir-baked SEMEN RAPHANI crude drug amount 6.0g/Kg body weight, gastric infusion, the life of hypertension model control group gavage equivalent
Manage salt solution, Irbesartan control group gavage Irbesartan 15mg/Kg body weight, Normal group gavage normal saline.Every group
10, treat 1 week.
Blood pressure measurement：By 38 DEG C of preheating 5-10min of rat, to avoid the less survey of rat tailses CBF from can't get a blood pressure reading.
In the case where rat regains consciousness rest state, the continuous average for measuring 3 times, 3 times is used as the mouse pressure value.Measurement treatment 1 day, 3 days, 5 days, 7
It blood pressure, was measured in 2 hours after administration.
【Experimental result】
Blood pressure dataSee the table 1 of experiment 3, test 3 table 2, when treating 7 days, dendrobium candidum group blood pressure 189.1
± 5.31/145.7 ± 4.14mmHg, stir-baked SEMEN RAPHANI group blood pressure 187.5 ± 5.68/146.5 ± 5.11mmHg, combination group blood pressure
174.1 ± 4.23/132.8 ± 4.98mmHg, substantially less than 209.4 ± 5.91/158.8 of model group blood pressure ± 3.35mmHg (P
<0.05).Combination group blood pressure is significantly compared with two alone group of lower (P of dendrobium candidum group and stir-baked SEMEN RAPHANI group<0.05).
Combination group antihypertensive effect is close with Western medicine Irbesartan control group.
The suitable adult human dose of rat dosage correspondence used in this experiment：
The suitable adult human dose of dendrobium candidum group correspondence is about crude drug amount 15g/ days；
The suitable adult human dose of stir-baked SEMEN RAPHANI group correspondence is about crude drug amount 60g/ days；
The suitable adult human dose of combination group correspondence is about 60g/ days total crude drug amount 75g/ of 15g/ days+stir-baked SEMEN RAPHANI of dendrobium candidum
Day；
The suitable adult human dose of Irbesartan control group correspondence is about Irbesartan 150mg/ days.
【Conclusion】
Dendrobium candidum (crude drug amount 1.5g/Kg body weight), stir-baked SEMEN RAPHANI (crude drug amount 6.0g/Kg body weight), dendrobium candidum (crude drug
Amount 1.5g/Kg body weight) and stir-baked SEMEN RAPHANI (crude drug amount 6.0g/Kg body weight) share and have antihypertensive effect to SHR.Two medicines are shared than list
The antihypertensive effect of medicine is significantly improved, and the antihypertensive effect that two medicines are shared is suitable with Irbesartan (15mg/Kg body weight).
Experiment 3：The dendrobium candidum of table 1 and stir-baked SEMEN RAPHANI to SHR rat systolic pressures influence (Unit：mmHg)
Note：Compared △ P with model group<0.05▲P<0.01.Dendrobium candidum group, stir-baked SEMEN RAPHANI group are compared P with combination group<
0.05■P<0.01。
Experiment 3：The dendrobium candidum of table 2 and stir-baked SEMEN RAPHANI to SHR rats diastolic pressures influence (Unit：mmHg)
Note：Compared △ P with model group<0.05▲P<0.01.Dendrobium candidum group, stir-baked SEMEN RAPHANI group are compared P with combination group<
0.05■P<0.01。
Typical cases
Female, 49 years old, accounting.There is hypertensive stroke family history, find hypertension about 3 years, Western medicine depressor control had not been taken
Blood pressure processed.The mean blood pressure 155/84mmHg in afternoon of on 2 4th, 2017 to 2 weeks on the 17th 2 months, 58.2 beats/min of heart rate.Sleep in the evening
The dormancy time is less, vexed, dreaminess, being irritable and getting angry easily, dry and hard excrement.
Start within 18 days 2 months, take 1 sample of embodiment 10g/ times, 2 times/day.The 18 days 2 months afternoons to 2 weeks March 3 day were averaged
Blood pressure 144/78mmHg, 57.9 beats/min of heart rate.Start since taking Chinese medicine, substantially increase the length of one's sleep in the evening, second day spirit
Full, dreaminess is reduced, and mood improves, and is defecated smooth.
【Conclusion】
The case age is the Menopause age, sleep easily occurs and reduces, vexed dreaminess, being irritable and getting angry easily, dry and hard excrement
Etc. symptom.While taking drop in blood pressure after the sample of embodiment 1, sleep and mood are obviously improved.So being determined in long-term use
Medicine is nursed one's health to control blood pressure, to reduce the various problems that Western medicine Blood pressure decresing belt comes.
Claims (7)
1. a kind of method that treatment hypertension drug is prepared as main material using dendrobium candidum and radish seed, it is characterised in that including under
State step：
(1) 2015 editions are pressed《Chinese Pharmacopoeia》In requirement, take 2.5-15 parts of dendrobium candidum, 2.5-60 parts of stir-baked SEMEN RAPHANI, the tuber of dwarf lilyturf
2.5-15 parts, 2.5-15 parts of the root of herbaceous peony, the number are parts by weight；
(2) mixed after grinding stir-baked SEMEN RAPHANI, the tuber of dwarf lilyturf and the root of herbaceous peony respectively, heating water is extracted, concentration, obtain water and extract concentrate；
(3) dendrobium candidum is ground to it is powdered, add water extract concentrate in；Then added according to pharmacy Conventional processing methods
Auxiliary material, is made Chinese medicinal tablet, particle, pill or capsule, obtains the medicine for treating hypertension.
2. the application method of the hypertension drug prepared in claim 1 methods described, it is characterised in that be to obtain preparation
Chinese medicinal tablet, particle, pill or the capsule obtained is with oral way medication, and adult is per consumption per day equivalent to crude drug amount 10g to 105g.
3. the hypertension drug prepared in claim 1 methods described is used as the application of health food, it is characterised in that be
The Chinese medicinal tablet, particle, pill or capsule are used as health food with oral way, adult is per consumption per day equivalent to life
Dose 10g to 105g.
4. a kind of method that treatment hypertension drug is prepared as main material using dendrobium candidum and radish seed, it is characterised in that including under
State step：
(1) 2015 editions are pressed《Chinese Pharmacopoeia》In requirement, take 5-30 parts of dendrobium candidum, 5-120 parts of stir-baked SEMEN RAPHANI, tuber of dwarf lilyturf 5-30
Part, 5-30 parts of the root of herbaceous peony, the number are parts by weight；
(2) four kinds of medicinal materials are ground to powdered, then carry out alcohol extracting：Plus 75% ethanol of 5 times of crude drug amounts, 60 DEG C of extractions 24 are small
When, extract 2 times altogether, reclaim ethanol；After alcohol extracting, residue carries out water extraction process again, concentration, merges the extraction that alcohol extracting and water are extracted
Liquid；
(3) auxiliary material is added according to pharmacy Conventional processing methods, Chinese medicinal tablet, particle, pill or capsule is made, obtain being used to treat
The medicine of hypertension.
5. method according to claim 4, it is characterised in that it is gradient-heated water extraction twice that the water, which is extracted,；Wherein
First time water controls Extracting temperature to be 100 DEG C when extracting, second of water controls Extracting temperature to be 121 DEG C when extracting, merge twice
Extract solution.
6. the application method of the hypertension drug prepared in the methods described of claim 4 or 5, it is characterised in that be to make
Standby Chinese medicinal tablet, particle, pill or the capsule obtained is with oral way medication, and the every consumption per day of adult is equivalent to crude drug amount 10g extremely
150g。
7. the hypertension drug prepared in the methods described of claim 4 or 5 exists as the application of health food, its feature
In, it is to use the Chinese medicinal tablet, particle, pill or capsule with oral way as health food, the every consumption per day phase of adult
When in crude drug amount 10g to 150g.
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| CN113115947A (en) * | 2018-07-08 | 2021-07-16 | 杭州丹鹤医药有限公司 | A method for preparing health food from radix Paeoniae alba |
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| WO2019056908A1 (en) * | 2017-09-20 | 2019-03-28 | 杭州丹鹤医药有限公司 | Application method of dendrobium candidum in preparing medicine for treating hypertension |
| CN113115947A (en) * | 2018-07-08 | 2021-07-16 | 杭州丹鹤医药有限公司 | A method for preparing health food from radix Paeoniae alba |
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| CN109700939A (en) * | 2019-02-27 | 2019-05-03 | 杭州丹鹤医药有限公司 | Dendrobium candidum leaf, rhizoma polygonati and radish seed are applied in preparation treatment hypertension drug |
| CN109700939B (en) * | 2019-02-27 | 2022-01-07 | 杭州丹鹤医药有限公司 | Application of dendrobium officinale leaf, rhizoma polygonati and radish seed in preparation of medicine for treating hypertension |
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