CN107595698A - It is a kind of to be used to remove removing abnormal flavor in oral cavity, the antibacterial and oral hygiene spray that refreshes the mind - Google Patents

It is a kind of to be used to remove removing abnormal flavor in oral cavity, the antibacterial and oral hygiene spray that refreshes the mind Download PDF

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Publication number
CN107595698A
CN107595698A CN201710885020.5A CN201710885020A CN107595698A CN 107595698 A CN107595698 A CN 107595698A CN 201710885020 A CN201710885020 A CN 201710885020A CN 107595698 A CN107595698 A CN 107595698A
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China
Prior art keywords
oral
oral hygiene
hygiene spray
oral cavity
mind
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Pending
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CN201710885020.5A
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Chinese (zh)
Inventor
常雪妮
谢知芳
蒋丽娟
薛建龙
纳泽·米尔
冯立雄
基特·彦姆
迈克尔·里奥尼德斯·崎肯德思
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Qiaokang Biotech Guangdong Co Ltd
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Xi'an Rogers Biological Science And Technology Co Ltd
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Priority to CN201710885020.5A priority Critical patent/CN107595698A/en
Publication of CN107595698A publication Critical patent/CN107595698A/en
Pending legal-status Critical Current

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  • Medicinal Preparation (AREA)

Abstract

The present invention, which provides, a kind of to be used to remove removing abnormal flavor in oral cavity, antibacterial, the oral hygiene spray that refreshes the mind, in percentage by weight, the oral hygiene spray includes 0.00005%~0.003% deionized water for going removing abnormal flavor in oral cavity/antibacterial substance, 0.001%~0.2% surfactant, 5%~20% moisturizing stabilizer, 0.001%~0.5% flavouring, 0.5%~15% material that refreshes the mind, 0.001%~0.5% pH value regulator and surplus.The oral hygiene spray can aid in oral health, reduce mouth disease added with removing removing abnormal flavor in oral cavity/antibacterial substance and refresh the mind material, refresh oneself when can work, learn or human communication in adjust oral cavity smell.Experiment proves, the oral hygiene spray can remove rapidly garlicky on blank sheet of paper, its inhibiting rate to common causative microorganism (staphylococcus aureus, Escherichia coli, candida albicanses) is up to 99%, can effectively reach removing abnormal flavor in oral cavity, antibacterial purpose.

Description

It is a kind of to be used to remove removing abnormal flavor in oral cavity, the antibacterial and oral hygiene spray that refreshes the mind
Technical field
It is more particularly to a kind of to be used to going removing abnormal flavor in oral cavity, antibacterial and refresh the mind the invention belongs to daily chemicals field Oral hygiene spray.
Background technology
With the development of the society, people also increasingly improve for the health care demand in oral cavity.But at the same time, China oral cavity disease The illness rate of disease is high, scope is wide, and the permanent teeth caries prevalence rate being grown up according to statistics is 49.88%, periodontosis illness rate about 90%, and oral cavity is protected The strong, importance of teeth caring is increasingly valued by the people.The health care in oral cavity includes preventing carious tooth, suppresses oral bacteria and removal Oral peculiar smell.The main reason of these problems is that bacterium, host and three big factor interaction of diet cause a disease, and these three factors In again headed by the influence of bacterium.Oral bacteria fermented foodstuff residue, sour and various sulfide is produced, on the one hand corrodes tooth glaze Face forms bacterial plaque, on the one hand causes halitosis, has a strong impact on people's quality of life.The influence of oral cavity anaerobium is eliminated, is removed Oral peculiar smell, depend merely on daily finite number of time brush teeth be it is inadequate, mouth sprays with the characteristics of its is convenient, efficient, raciness into For the important means of oral care.But the mouth sprays class product of current commercial type, therapeutic type often using Tinidazole, Must wash too, sodium fluoride composition carry out inhibiting bacteria and diminishing inflammation, these compositions are not easy to be metabolized, long-term use can cause bad to human body or environment Influence, and daily mouth sprays class product is mostly fresh breath class, bactericidal effect does not reach expected requirement.
Chlorine dioxide antiseptic power is strong, has a broad antifungal spectrum, has killing action to bacterium, virus, fungi and gemma etc., and act on Rapidly, bactericidal effect is influenceed small by environmental condition (temperature, pH value, organic matter), nontoxic, non-stimulated, environmentally safe, in Europe Man of the U.S. is used in many oral care products, for tooth whitening and health care, pre- anti-caries and periodontal disease, especially uses In the preventing and treating of halitosis.Experimental results demonstrate chlorine dioxide can kill oral cavity anaerobium, halitosis, oral health effect are fundamentally treated Fruit is significantly better than other products.
The content of the invention
It is used to go removing abnormal flavor in oral cavity, oral hygiene that is antibacterial and refreshing the mind to spray it is an object of the invention to provide a kind of Agent, in favor of the oral health of user, reduce mouth disease, and refresh oneself in work, study or human communication in adjust Save oral cavity smell.
The present invention is to be achieved through the following technical solutions:
It is a kind of to be used to remove removing abnormal flavor in oral cavity, antibacterial, the oral hygiene spray that refreshes the mind, in percentage by weight, should Oral hygiene spray includes 0.00005%~0.003% and removes removing abnormal flavor in oral cavity/antibacterial substance, 0.001%~0.2% table Face activating agent, 5%~20% moisturizing stabilizer, 0.001%~0.5% flavouring, 0.5%~15% thing that refreshes the mind The deionized water of matter, 0.001%~0.5% pH value regulator and surplus.
Preferably, the described removing abnormal flavor in oral cavity/antibacterial substance that goes is chlorine dioxide.
Preferably, the percentage by weight of chlorine dioxide is 0.0003%~0.001%.
Preferably, described surfactant is Tween-80, poloxamer188, one kind in sldium lauryl sulfate or several Kind.
Preferably, described moisturizing stabilizer is the mixture of propane diols and glycerine.
Preferably, described flavouring is one kind in saccharin sodium, acesulfame potassium, stevioside, xylitol, D-sorbite It is or several.
Preferably, described flavouring is the mixture of acesulfame potassium, stevioside, xylitol and D-sorbite.
Preferably, the material that refreshes the mind is water-soluble Mint Essence, menthol, one kind in peppermint hydrosol or more Kind.
Preferably, the pH value regulator is the mixture of citric acid and sodium acid carbonate.
Preferably, the percentage by weight of the material that refreshes the mind is 3%~6%.
Preferably, pH value regulator is passed through so that the pH value of oral hygiene spray is 6.2~7.6.
It is further preferred that the pH value of oral hygiene spray is 6.8~7.2.
Preferably, the oral hygiene spray solution of all components composition is packaged in aluminium aerosol bottle.
Compared with prior art, the present invention has technique effect beneficial below:
It is provided by the invention it is a kind of be used to remove removing abnormal flavor in oral cavity, antibacterial, the oral hygiene spray that refreshes the mind, according to weight Percentages, the oral hygiene spray include 0.00005%~0.003% and remove removing abnormal flavor in oral cavity/antibacterial substance, 0.001% ~0.2% surfactant, 5%~20% moisturizing stabilizer, 0.05%~2% flavouring, 0.5%~15% carry The deionized water of refreshing restoring consciouness material, 0.001%~0.5% pH value regulator and surplus.The oral hygiene spray is added with and gone Removing abnormal flavor in oral cavity/antibacterial substance and the material that refreshes the mind, can aid in oral health, reduce mouth disease, Neng Gougong Make, study when refresh oneself or human communication in adjust oral cavity smell.It is demonstrated experimentally that the oral hygiene spray can remove blank sheet of paper rapidly On it is garlicky, its inhibiting rate to common causative microorganism (staphylococcus aureus, Escherichia coli, candida albicanses) is up to 99%, it can effectively reach removing abnormal flavor in oral cavity, antibacterial purpose.
Brief description of the drawings
Fig. 1 be oral hygiene spray to garlic flavour removal effect figure, wherein, " processing " be handled using oral hygiene spray Blank sheet of paper, " control " is the blank sheet of paper that is not handled by oral hygiene spray.
Fig. 2 is inhibition of the oral hygiene spray to different microorganisms.
Embodiment
With reference to specific embodiment, the present invention is described in further detail, it is described be explanation of the invention and It is not to limit.
It is an object of the invention to provide a kind of oral hygiene spray, and suitable for masses, especially smoking, there have with oral cavity to be different Taste crowd, for removing removing abnormal flavor in oral cavity, antibacterial and refresh the mind.
The oral hygiene spray include go removing abnormal flavor in oral cavity/antibacterial substance, surfactant, moisturizing stabilizer, flavouring, Refresh the mind material, pH value regulator and deionized water.Its concrete component and percentage by weight are as follows:
1) removing abnormal flavor in oral cavity/antibacterial substance is gone to select high-pure chlorinedioxide, percentage by weight is 0.00005%~ 0.003%, preferably 0.0003%~0.001%;
2) surfactant is preferably moored from the one or more in Tween 80, poloxamer188, sldium lauryl sulfate Luo Shamu 407;Percentage by weight is 0.001%~0.2%, preferably 0.015%~0.017%;
3) moisturizing stabilizer from propane diols, the mixture of glycerine, percentage by weight be 5%~20%, preferably 10%~ 15%;
4) flavouring is excellent from the one or more in saccharin sodium, acesulfame potassium, stevioside, xylitol, D-sorbite Select acesulfame potassium, stevioside, xylitol and D-sorbite;0.05%~2%, preferably 0.09%~0.13%;
5) material that refreshes the mind is preferably thin from the one or more in water-soluble Mint Essence, menthol, peppermint hydrosol Lotus alcohol and peppermint hydrosol;Percentage by weight is 0.5%~15%, preferably 3%~6%.
6) for pH value regulator from citric acid and the mixture of sodium acid carbonate, percentage by weight is 0.001%~0.5%.
The preparation method of the oral hygiene spray of the present invention:Above-mentioned all components are proportionally added into appropriate amount of deionized water Constant volume after middle dissolving, use;Aluminium aerosol bottle is packed.By taking 100mL as an example, above-mentioned all components are proportionally added into 90mL Dissolved in deionized water, be settled to 100mL, packed using aluminium aerosol bottle.
Oral hygiene spray provided by the invention, wherein removing abnormal flavor in oral cavity, the antibacterial and material that refreshes the mind are added, Long-term use, being advantageous to all groups, especially oral cavity has the oral health of peculiar smell or smoking crowd, can less mouth disease hair It is raw;With the addition of the material to refresh the mind, available for work, study when refresh oneself or human communication in adjust oral cavity smell.With it is existing Technology is compared, and composition is safer, more effective, is adapted to consumers in general, and is existed with aluminum spray form, has composition steady Determine, absorb the advantages of rapid, easy to use, widely applicable.
Oral hygiene spray provided by the invention has advantages below:
1. Efficient antibacterial --- to the inhibiting rate of harmful bacteria up to 99%, effectively safeguard that oral cavity flora balances;
2. fresh breath --- oral peculiar smell can be quickly eliminated, effectively prevention, alleviation halitosis, possess pure and fresh mouth whenever and wherever possible Gas;
3. anti-inflammatory is calm --- can quickly calm down that inflammation brings is not to feel, brings the oral experience releived;
4. nursing is comprehensive --- it is simple to spray, sterilize, clean the teeth, the completion of the step of permanent tooth one, being more simply, more easily Oral care method.
5. refresh the mind --- effect that is refrigerant, refreshing oneself is produced by rapid stimulation oral mucosa.
Embodiment 1
Preparation method:By taking 100mL as an example, above-mentioned all components are proportionally added in 90mL deionized waters and dissolved, it is fixed Hold to 100mL, packed using aluminium aerosol bottle.
Embodiment 2
Preparation method:By taking 100mL as an example, above-mentioned all components are proportionally added in 90mL deionized waters and dissolved, it is fixed Hold to 100mL, packed using aluminium aerosol bottle.
Embodiment 3
Preparation method:By taking 100mL as an example, above-mentioned all components are proportionally added in 90mL deionized waters and dissolved, it is fixed Hold to 100mL, packed using aluminium aerosol bottle.
The oral hygiene spray of embodiment 4 eliminates garlic flavour
Oral hygiene spray is prepared according to embodiment 3,7g mashed garlic is applied to blank sheet of paper center in a manner of rolling, sprayed with oral cavity Agent uniformly spray 3 times on blank sheet of paper central point, blank sheet of paper is placed at dry shady and cool ventilation, every 1min, is evaluated garlicky dense on blank sheet of paper Degree, evaluate the people of number 10.Initial garlicky concentration is designated as 100, and 0 is designated as without garlicky, and other concentration take same according to garlicky deep or light marking One time point more people averages of giving a mark are the time point garlicky concentration score value, using the score value and the percentage of initial garlicky concentration as Garlicky residual rate, residual rate are more low better.As a result show in Fig. 1.As a result show, when the oral hygiene spray for being sprayed with the present invention Afterwards, on blank sheet of paper it is garlicky it is rapid eliminate, can reduce about 80% when about 45%, three minutes can be reduced at one minute, eight minutes When garlicky basic disappear;Without treated blank sheet of paper, at three minutes it is garlicky still have about 95% residual, garlic at eight minutes Taste residual about 90%.Therefore, oral hygiene spray of the invention can be eliminated significantly garlicky, and this shows that the oral cavity of the present invention is defended Raw spray has splendid effect in elimination oral peculiar smell field.
The fungistatic effect of embodiment 5 is tested
The gargle that embodiment 3 obtains is measured according to fungistatic effect method of testing described in GB15979-2002, counted Calculate bacteriostasis rate.Experimental results show in fig. 2, wherein, if bacteriostasis rate is X%, logarithm bacteriostasis rate is lgX.Experiment shows, The oral hygiene spray of the present invention is to Common detrimental microorganism (staphylococcus aureus, Escherichia coli, candida albicanses) Inhibiting rate to more than 99%, has good fungistatic effect.

Claims (9)

1. a kind of be used to remove removing abnormal flavor in oral cavity, antibacterial, the oral hygiene spray that refreshes the mind, it is characterised in that according to weight hundred Point than meter, the oral hygiene spray include 0.00005%~0.003% go removing abnormal flavor in oral cavity/antibacterial substance, 0.001%~ 0.2% surfactant, 5%~20% moisturizing stabilizer, 0.001%~0.5% flavouring, 0.5%~15% Refresh the mind the deionized water of material, 0.001%~0.5% pH value regulator and surplus.
2. oral hygiene spray according to claim 1, it is characterised in that described removes removing abnormal flavor in oral cavity/antibacterial substance For chlorine dioxide.
3. oral hygiene spray according to claim 2, it is characterised in that the percentage by weight of chlorine dioxide is 0.0003%~0.001%.
4. oral hygiene spray according to claim 1, it is characterised in that described surfactant is Tween-80, pool One or more in Luo Shamu 407, sldium lauryl sulfate.
5. oral hygiene spray according to claim 1, it is characterised in that described moisturizing stabilizer is propane diols and sweet The mixture of oil.
6. oral hygiene spray according to claim 1, it is characterised in that described flavouring be saccharin sodium, acesulfame potassium, One or more in stevioside, xylitol, D-sorbite.
7. oral hygiene spray according to claim 1, it is characterised in that described flavouring is acesulfame potassium, STEVIA REBAUDIANA The mixture of glucosides, xylitol and D-sorbite.
8. oral hygiene spray according to claim 1, it is characterised in that the material that refreshes the mind is water-soluble peppermint One or more in essence, menthol, peppermint hydrosol.
9. oral hygiene spray according to claim 1, it is characterised in that the pH value regulator is citric acid and carbonic acid The mixture of hydrogen sodium.
CN201710885020.5A 2017-09-26 2017-09-26 It is a kind of to be used to remove removing abnormal flavor in oral cavity, the antibacterial and oral hygiene spray that refreshes the mind Pending CN107595698A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108853137A (en) * 2018-09-20 2018-11-23 广东山石微量元素研究院(普通合伙) Mouth sprays of the microelement containing Khotan jade and preparation method thereof
CN110327250A (en) * 2018-06-08 2019-10-15 中国医学科学院药用植物研究所 A kind of pure natural sterilizing oral spray and preparation method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1222345A (en) * 1997-12-01 1999-07-14 段建涛 Gargle containing chlorine dioxide
CN105125690A (en) * 2015-09-23 2015-12-09 北京水木中天植物科学研究院 Oral anti-inflammation spray
CN105125448A (en) * 2015-09-23 2015-12-09 北京水木中天植物科学研究院 Oral sanitary spray
CN105147612A (en) * 2015-09-23 2015-12-16 北京水木中天植物科学研究院 Oral cavity refreshing spray agent

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1222345A (en) * 1997-12-01 1999-07-14 段建涛 Gargle containing chlorine dioxide
CN105125690A (en) * 2015-09-23 2015-12-09 北京水木中天植物科学研究院 Oral anti-inflammation spray
CN105125448A (en) * 2015-09-23 2015-12-09 北京水木中天植物科学研究院 Oral sanitary spray
CN105147612A (en) * 2015-09-23 2015-12-16 北京水木中天植物科学研究院 Oral cavity refreshing spray agent

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110327250A (en) * 2018-06-08 2019-10-15 中国医学科学院药用植物研究所 A kind of pure natural sterilizing oral spray and preparation method thereof
CN110327250B (en) * 2018-06-08 2023-04-14 中国医学科学院药用植物研究所 Pure natural oral sterilization spray and preparation method thereof
CN108853137A (en) * 2018-09-20 2018-11-23 广东山石微量元素研究院(普通合伙) Mouth sprays of the microelement containing Khotan jade and preparation method thereof

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Address after: 511400 Room 1301, 132, Nansha Street, Nansha District, Guangzhou, Guangdong Province, South 162 Qian Avenue, Nansha Street (office only)

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