CN107531677A - 用于制备托匹司他及其中间体的方法 - Google Patents

用于制备托匹司他及其中间体的方法 Download PDF

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Publication number
CN107531677A
CN107531677A CN201680023004.9A CN201680023004A CN107531677A CN 107531677 A CN107531677 A CN 107531677A CN 201680023004 A CN201680023004 A CN 201680023004A CN 107531677 A CN107531677 A CN 107531677A
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China
Prior art keywords
formula
compound
acceptable salt
hydrate
pharmaceutically acceptable
Prior art date
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Pending
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CN201680023004.9A
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English (en)
Chinese (zh)
Inventor
V·T·卡夫提斯
E·尼尔科斯米蒂斯
T·安德烈乌
C·斯泰撒基斯
P·格卡兹赛尔
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Pharmathen SA
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Pharmathen SA
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Publication of CN107531677A publication Critical patent/CN107531677A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
CN201680023004.9A 2015-02-25 2016-02-24 用于制备托匹司他及其中间体的方法 Pending CN107531677A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP2015000430 2015-02-25
EPPCT/EP2015/000430 2015-02-25
PCT/EP2016/000343 WO2016134854A1 (en) 2015-02-25 2016-02-24 Methods for the preparation of topiroxostat and intermediates thereof

Publications (1)

Publication Number Publication Date
CN107531677A true CN107531677A (zh) 2018-01-02

Family

ID=55484946

Family Applications (1)

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CN201680023004.9A Pending CN107531677A (zh) 2015-02-25 2016-02-24 用于制备托匹司他及其中间体的方法

Country Status (3)

Country Link
JP (1) JP6811717B2 (https=)
CN (1) CN107531677A (https=)
WO (1) WO2016134854A1 (https=)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113666909A (zh) * 2020-05-14 2021-11-19 鲁南制药集团股份有限公司 一种托匹司他的制备方法
CN114685451A (zh) * 2020-12-30 2022-07-01 鲁南制药集团股份有限公司 马来酸托匹司他二水合物共晶及其制备方法
CN114685452A (zh) * 2020-12-31 2022-07-01 鲁南制药集团股份有限公司 一种托匹司他-水杨酸-乙酸三元共晶
CN115477638A (zh) * 2022-10-09 2022-12-16 浙江神洲药业有限公司 一种托匹司他的制备方法
CN115572747A (zh) * 2022-09-23 2023-01-06 湖南一格制药有限公司 托匹司他的制备方法
CN115925682A (zh) * 2021-10-04 2023-04-07 山东新时代药业有限公司 一种托匹司他的合成方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108250183A (zh) * 2016-12-29 2018-07-06 北京诚济制药有限公司 一种高纯度的托匹司他的制备方法
CN115308347B (zh) * 2022-09-01 2023-09-08 江苏知原药业股份有限公司 一种托吡司特中氮氧化物杂质的分析方法
CN116396275B (zh) * 2023-03-03 2025-05-13 浙江国邦药业有限公司 一种托匹司他的合成方法

Citations (3)

* Cited by examiner, † Cited by third party
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US20060189811A1 (en) * 2004-07-23 2006-08-24 Fujiyakuhin Co., Ltd. Process for producing 1,2,4-triazole compound and intermediate therefor
CN1561340B (zh) * 2002-01-28 2012-05-23 株式会社富士药品 1,2,4-三唑类化合物
CN103724329A (zh) * 2013-12-23 2014-04-16 济南百诺医药科技开发有限公司 4-[5-(吡啶-4-基)-1h-[1,2,4]三唑-3-基]吡啶-2-甲腈的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0979822T3 (da) * 1998-08-10 2006-03-27 Hoffmann La Roche Fremgangsmåde til fremstilling af 2-carbamoyl-pyridiner
MXPA03007513A (es) * 2001-02-21 2004-07-30 Nps Pharma Inc Compuestos heteropoliciclicos y su uso como antagonistas del receptor metabotropico de glutamato.
CN1826335A (zh) * 2003-07-24 2006-08-30 株式会社富士药品 1,2,4－三唑化合物的制造方法以及其中间体
JP2005041802A (ja) * 2003-07-25 2005-02-17 Fujiyakuhin Co Ltd １，２，４−トリアゾール化合物の製造方法
CA2876391C (en) 2012-07-25 2016-10-18 Fujiyakuhin Co., Ltd. 4-[5-(pyridin-4-yl)-1h-1,2,4-triazol-3-yl]pyridine-2-carbonitrile crystalline polymorph and production method therefor
IN2014DN10530A (https=) 2012-07-25 2015-08-21 Fujiyakuhin Co Ltd

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1561340B (zh) * 2002-01-28 2012-05-23 株式会社富士药品 1,2,4-三唑类化合物
US20060189811A1 (en) * 2004-07-23 2006-08-24 Fujiyakuhin Co., Ltd. Process for producing 1,2,4-triazole compound and intermediate therefor
CN103724329A (zh) * 2013-12-23 2014-04-16 济南百诺医药科技开发有限公司 4-[5-(吡啶-4-基)-1h-[1,2,4]三唑-3-基]吡啶-2-甲腈的制备方法

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113666909A (zh) * 2020-05-14 2021-11-19 鲁南制药集团股份有限公司 一种托匹司他的制备方法
CN114685451A (zh) * 2020-12-30 2022-07-01 鲁南制药集团股份有限公司 马来酸托匹司他二水合物共晶及其制备方法
CN114685452A (zh) * 2020-12-31 2022-07-01 鲁南制药集团股份有限公司 一种托匹司他-水杨酸-乙酸三元共晶
CN115925682A (zh) * 2021-10-04 2023-04-07 山东新时代药业有限公司 一种托匹司他的合成方法
CN115925682B (zh) * 2021-10-04 2025-11-25 山东新时代药业有限公司 一种托匹司他的合成方法
CN115572747A (zh) * 2022-09-23 2023-01-06 湖南一格制药有限公司 托匹司他的制备方法
CN115572747B (zh) * 2022-09-23 2023-05-05 湖南一格制药有限公司 托匹司他的制备方法
CN115477638A (zh) * 2022-10-09 2022-12-16 浙江神洲药业有限公司 一种托匹司他的制备方法

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JP6811717B2 (ja) 2021-01-13
JP2018507858A (ja) 2018-03-22
WO2016134854A1 (en) 2016-09-01

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