CN107519322B - Traditional Chinese medicine spray for preventing and treating salpingitis of hens in cloacal administration mode - Google Patents
Traditional Chinese medicine spray for preventing and treating salpingitis of hens in cloacal administration mode Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine spray for preventing and treating hen salpingitis by a cloaca administration mode, which is prepared by the following steps: the preparation method comprises the steps of firstly selecting traditional Chinese medicinal materials such as pine needle, astragalus, cyrtomium rhizome, loquat leaf, dandelion, agilawood and gelsemium, then cleaning, drying, mixing and crushing, adding boiling water, stirring into pasty traditional Chinese medicine powder, freezing and thawing, carrying out first alcohol extraction, carrying out second alcohol extraction, carrying out third alcohol extraction, combining filtrates, removing ethanol, adding drinking water, stirring, concentrating, and finally filling. The traditional Chinese medicine spray disclosed by the invention has the characteristics of environmental friendliness, small toxic and side effects, avoidance of damage to chicken livers and intestines and stomach, and improvement of the production performance of hens.
Description
Technical Field
The invention relates to the technical field of traditional Chinese veterinary medicines, in particular to the technical field of traditional Chinese veterinary medicines for adjuvant therapy of salpingitis of hens.
Background
The hen is suffered from salpingitis due to multiple reasons, the etiology is complex, and the sanitary condition of a chicken coop is poor; the cloaca is contaminated by bacteria (such as white dysentery salpingitis, paratyphoid bacillus, Escherichia coli, etc.) and invades the oviduct; or feeding animal feed too much; over-laying or double-yellow egg laying; sometimes, egg shells are broken in fallopian tubes, so that the fallopian tubes are damaged, egg laying is excessive, corresponding vitamins are lacked in feed, stress of chicken flocks and the like can all cause salpingitis. The hens suffer from salpingitis and often cause symptoms of intolerable pain of a reproductive system, fallopian tube prolapse, dystocia, increase of unqualified eggs such as broken eggs and eggshells, incapability of laying eggs and the like, and the breeding profits of the laying hens and the breeding hens are seriously influenced. At present, the main administration mode for preventing and treating chicken salpingitis is drinking water or mixing materials, and the administration routes all need to be detoxified by the liver. The two administration routes can cause the increase of the fat content of the liver and the steatosis; causing cholestatic jaundice, hepatocyte necrosis, increase of glutamic-pyruvic transaminase, and even fatal fatty liver; increase of liver transaminase, hepatomegaly, and the like, thereby reducing the body resistance of the chicken.
The periphery of the cloaca of the hen is rich in arteries, veins and lymphatic plexus, and the cloaca mucosa has a strong absorption function. Cloacal administration refers to an administration method in which a drug is delivered into a large intestine tube through a cloacal cavity, enters the major circulation through rapid absorption of cloacal mucosa, and exerts drug effects to treat systemic or local diseases. The drug is administered through the cloaca, the drug is mixed in the secretion of the cloaca and absorbed through the mucosa of the large intestine, and the drug does not pass through the liver, so that the first-pass detoxification effect of the liver is avoided, the blood concentration is improved, and the liver is not damaged; the medicine does not pass through the stomach and the small intestine, thereby avoiding the influence and damage of acid and alkali digestive enzyme on the medicine, relieving the stimulation of the medicine to the gastrointestinal tract, and greatly improving the bioavailability of the medicine by the chicken through cloacal administration.
Disclosure of Invention
An object of the present invention is to solve at least the above problems and to provide at least the advantages described later.
The invention also aims to provide a traditional Chinese medicine spray for preventing and treating the salpingitis of the hens by a cloaca administration mode, which has the characteristics of environmental protection, small toxic and side effects, avoidance of damage to chicken livers and intestines and stomach, and improvement of the production performance of the hens.
To achieve these objects and other advantages in accordance with the present invention, there is provided a Chinese medicinal spray for preventing and treating salpingitis in hens by cloacal administration, which is prepared by the following steps: the preparation method comprises the steps of firstly selecting traditional Chinese medicinal materials such as pine needle, astragalus, cyrtomium rhizome, loquat leaf, dandelion, agilawood and gelsemium, then cleaning, drying, mixing and crushing, adding boiling water, stirring into pasty traditional Chinese medicine powder, freezing and thawing, carrying out first alcohol extraction, carrying out second alcohol extraction, carrying out third alcohol extraction, combining filtrates, removing ethanol, adding drinking water, stirring, concentrating, and finally filling.
Preferably, the traditional Chinese medicine components are as follows in parts by weight: 30-35 parts of pine needle, 20-25 parts of astragalus membranaceus, 20-25 parts of cyrtomium rhizome, 10-15 parts of loquat leaf, 10-15 parts of dandelion, 2-6 parts of agilawood and 2-6 parts of gelsemium elegans; the traditional Chinese medicine spray for preventing and treating the salpingitis of the hens in the cloaca administration mode is prepared by comparing the effective components of the screened traditional Chinese medicines according to the compatibility principles of the traditional Chinese medicines of monarch, minister, assistant and guide, seven-emotion compatibility, nineteen incompatibilities and the like of the compound traditional Chinese medicines, repeatedly screening more than 300 traditional Chinese medicines according to the design function requirements on the basis of a large amount of clinical practices, and finally determining the formula for the prevention and treatment effect of the salpingitis of the hens; the pharmacological conditions of the traditional Chinese medicinal materials in the formula are as follows:
the folium Pini is needle leaf of Pinus sibirica, Pinus thunbergii, Pinus tabulaeformis, Pinus koraiensis, Pinus armandii, Pinus yunnanensis, Pinus sylvestris, Pinus massoniana, etc. of Pinus of Pinaceae, and has sour, bitter, warm, nontoxic, heart, spleen and liver meridians. It has effects in dispelling pathogenic wind, removing dampness, killing parasites, and relieving itching. The pine needles have the effects of treating diseases, preventing five internal organs, growing hair, resisting cold and summer heat, resisting wind and rain, lightening body, tonifying qi, keeping the middle warmer, preventing grains from prolonging life, removing pathogenic qi from pine leaves, keeping healthy and safe after removing pathogenic factors, preventing diseases from growing, and thus obtaining the actual effect of preventing hunger and prolonging life;
radix astragali, also called Mianqi, is a perennial herb and has the functions of enhancing the body immunity, protecting the liver, promoting urination, resisting aging, resisting stress, reducing blood pressure and having wider antibacterial and anti-inflammatory effects;
cyrtomium fortunei, a plant of the genus Dryopteris of the family Dryopteridaceae, has the effects of killing parasite, clearing heat, removing toxic substance, cooling blood, stopping bleeding, etc.;
folium Eriobotryae, leaves of Eriobotrya japonica of Rosaceae, also called Baba leaves and Lu orange leaves, has effects of resisting bacteria, relieving inflammation, clearing lung-heat, relieving cough, regulating stomach, promoting urination, and quenching thirst;
dandelion, a Compositae, belongs to perennial herb, and is sweet in nature and taste, slightly bitter and cold. It enters liver and stomach meridians. Has antibacterial, antiinflammatory, diuretic, laxative, jaundice eliminating, and gallbladder promoting effects;
lignum Aquilariae Resinatum (Aquilaria sinensis (lour.) Gilg) is resin-containing wood of Aquilaria sinensis (lour.) Gilg of Thymelaeaceae, and has effects of activating qi-flowing, relieving pain, warming middle-jiao, relieving vomit, and promoting inspiration to relieve asthma;
gelsemium elegans belongs to evergreen woody vine, is called as kudzu, caulis sprangleae, gelsemium elegans, gymnema occulta and the like, and has the effects of removing stasis and drawing out toxin, removing blood stasis and relieving pain, killing parasites and relieving itching, relieving pain, calming, resisting inflammation, resisting tumors and the like.
Preferably, in all working links of the flow preparation of the traditional Chinese medicine spray, except the freezing and thawing and stirring concentration links, the environment of other working links is 18-30 ℃, the relative humidity is 30-70%, and the cleanliness grade of a production area is a common production area.
Preferably, the pulverization of the Chinese medicinal material components is required to be pulverized into powder having a particle size of 100 mesh.
Preferably, the freeze-thawing process of the powder is as follows: the freeze thawing process of the medicinal powder comprises the following steps: adding boiling water into the medicinal powder, stirring to obtain paste, quickly freezing the paste at-25 deg.C for 24 hr, and thawing at 25 deg.C.
Preferably, the alcohol extraction is carried out for the first time, the alcohol extraction is carried out for the second time, and the specific steps of the alcohol extraction for the third time are as follows: mixing the pasty Chinese medicinal powder subjected to freeze thawing treatment with 95% ethanol solution at a mass ratio of 1:3, leaching at room temperature for 3h, vacuum filtering, repeating the operations for the second and third repeated ethanol extraction, mixing the filtrates, and distilling under reduced pressure to remove ethanol.
Preferably, the steps of removing ethanol and adding drinking water for stirring and concentrating are as follows: adding 5 times volume of drinking water into the ethanol extractive solution, stirring and concentrating in a vacuum rotary instrument with water bath constant temperature of 60 deg.C, concentrating until the weight of the medicinal liquid is the same as the total weight of the Chinese medicinal materials, and stopping concentration.
Preferably, the plastic spray bottle with the volume of 100ml is selected for the filling process.
The invention at least comprises the following beneficial effects: (1) the pure Chinese medicinal preparation has mild medicinal properties and no irritation to chickens; (2) the salpingitis of the hens in each stage of the egg laying period is effectively treated, and the production score of the hens is improved; (3) by cloacal administration, the medicine is absorbed through intestinal mucosa without damaging liver, thereby relieving the stimulation of the medicine to gastrointestinal tract, improving blood concentration and bioavailability of the medicine to chickens, and changing the traditional use method of the traditional Chinese medicine in the field of poultry production; (4) chinese-medicinal material is extracted through freeze thawing and organic extraction technique, and the extraction rate of active ingredient is showing and is promoting, chooses boiling water stirring powder for use, and the cell wall breaks the wall once more because of expend with heat and contract with cold principle, and in freezing link, according to the my Paoba effect principle, hot water freezes more fast than cold water, and the speed that moisture in the paste of normal atmospheric temperature forms the ice crystal is not fast that moisture forms the ice crystal in the high temperature paste, and the broken wall effect does not use high temperature boiling water stirring powder effectual.
Additional advantages, objects, and features of the invention will be set forth in part in the description which follows and in part will become apparent to those having ordinary skill in the art upon examination of the following or may be learned from practice of the invention.
Detailed Description
The present invention is further described in detail below with reference to examples so that those skilled in the art can practice the invention with reference to the description.
< example 1>
A traditional Chinese medicine spray for preventing and treating hen salpingitis by cloaca administration is prepared by the following steps: firstly, selecting the traditional Chinese medicinal materials of pine needle, astragalus root, cyrtomium rhizome, loquat leaf, dandelion, agilawood and gelsemium, then cleaning, drying, mixing and crushing, adding boiling water, stirring into pasty traditional Chinese medicine powder, freezing and thawing, carrying out first alcohol extraction, carrying out second alcohol extraction, carrying out third alcohol extraction, combining filtrates, removing ethanol, adding drinking water, stirring, concentrating, and finally filling.
< example 2>
A traditional Chinese medicine spray for preventing and treating hen salpingitis by cloaca administration comprises the following medicinal materials in parts by weight: 35 parts of pine needle, 25 parts of astragalus, 25 parts of cyrtomium rhizome, 15 parts of loquat leaf, 15 parts of dandelion, 6 parts of agilawood and 6 parts of gelsemium elegans, cleaning and drying the selected medicinal materials, crushing the medicinal materials into 100-mesh medicinal powder, stirring the crushed medicinal powder and a proper amount of boiling water into paste, quickly freezing the paste with higher temperature at the temperature of-25 ℃ for 24 hours, taking out the pasty Chinese medicinal powder after freezing for 24 hours, unfreezing the paste at the temperature of 25 ℃, mixing the pasty Chinese medicinal powder after freeze-thaw treatment with 95% ethanol solution according to the mass ratio of 1:3, leaching for 3 hours at normal temperature, filtering, repeating for 3 times (namely, carrying out primary ethanol extraction, secondary ethanol extraction and tertiary ethanol extraction processes), combining filtrate, carrying out reduced pressure distillation, volatilizing ethanol, adding 5 times of volume of drinking water, stirring and concentrating on a vacuum rotary instrument with the constant temperature of 60 ℃ in a water bath until the weight of the total medicinal materials is the same as that of the, filling into 100ml plastic spray bottle. In all working links of the process preparation of the traditional Chinese medicine spray, except freezing and thawing and stirring concentration links, the environment of other working links is 18-30 ℃, the relative humidity is 30-70 percent, and the cleanliness grade of a production area is a common production area. In 2016, 12/13 days, a brightly bright commercial laying hen farm was selected, a laying hen house with an laying rate of 55% was selected, and 122 hens with red and swollen bleeding symptoms in cloaca after turning anus were randomly selected and isolated and randomly divided into 2 groups of 61 hens. After the whole test group turned the anus, the liquid medicine was sprayed to the cloaca for 3 times for 5 days, and the control group was treated by the conventional method (adding anti-inflammatory agent to the feed, the same as in the examples below) for 5 days. After 5 days, the test group had 2 hens whose oviducts had slight inflammation, the remaining 59 hens were recovered to normal, the control group had 8 hens whose oviducts had slight inflammation, 2 hens whose salpingitis was not improved, and the remaining 51 hens were recovered to normal, and the beneficial effects of the present invention were obtained.
< example 3>
A traditional Chinese medicine spray for preventing and treating hen salpingitis by cloaca administration comprises the following medicinal materials in parts by weight: 35 parts of pine needle, 25 parts of astragalus, 25 parts of cyrtomium rhizome, 15 parts of loquat leaf, 15 parts of dandelion, 6 parts of agilawood and 6 parts of gelsemium elegans, and the selected medicinal materials are cleaned, dried and crushed into 100-mesh medicinal powder. Mixing the pulverized medicinal powder with appropriate amount of boiling water, stirring to obtain paste, quickly freezing the paste at-25 deg.C for 24 hr, taking out the paste after 24 hr, and thawing at 25 deg.C; mixing the pasty Chinese medicinal powder subjected to freeze thawing treatment with 95% ethanol solution at a mass ratio of 1:3, leaching at room temperature for 3h, vacuum filtering, repeating for 3 times (i.e. first ethanol extraction, second ethanol extraction, and third ethanol extraction), mixing filtrates, distilling under reduced pressure, volatilizing ethanol, adding 5 times volume of drinking water, stirring and concentrating on a vacuum rotary instrument with water bath constant temperature of 60 deg.C, concentrating to the same weight as the total weight of the raw medicinal materials, and bottling in 100ml plastic spray bottle. In all working links of the process preparation of the traditional Chinese medicine spray, except freezing and thawing and stirring concentration links, the environment of other working links is 18-30 ℃, the relative humidity is 30-70 percent, and the cleanliness grade of a production area is a common production area. In 2016, 12 and 13 months, in a brightly bright commercial laying hen farm, a laying hen house at the egg laying peak is selected, 100 hens with red and swollen bleeding symptoms in cloaca after turning anus are randomly selected and isolated, and the hens are randomly divided into 2 groups of 50 hens. After the whole test group overturns the anus, the liquid medicine is sprayed at the cloaca for 3 times continuously for 5 days, and the control group is treated for 5 days according to the conventional method. After 5 days, the test group had 1 hen with slight inflammation in the oviduct, the other 49 hens recovered to be normal, the control group had 6 hens with slight inflammation in the oviduct, 2 hens did not improve the salpingitis, and the other 42 hens recovered to be normal, so that the beneficial effects of the invention are achieved.
< example 4>
A traditional Chinese medicine spray for preventing and treating hen salpingitis by cloaca administration comprises the following medicinal materials in parts by weight: 33 parts of pine needle, 25 parts of astragalus, 20 parts of cyrtomium rhizome, 12 parts of loquat leaf, 12 parts of dandelion, 5 parts of agilawood and 5 parts of gelsemium elegans, and the selected medicinal materials are cleaned, dried and crushed into 100-mesh medicinal powder. Mixing the pulverized medicinal powder with appropriate amount of boiling water, stirring to obtain paste, and rapidly freezing the paste with high temperature at-25 deg.C for 24 hr; freezing for 24 hr, taking out the pasty Chinese medicinal powder, and thawing at 25 deg.C. Mixing the pasty Chinese medicinal powder subjected to freeze thawing treatment with 95% ethanol solution at a mass ratio of 1:3, leaching at room temperature for 3h, vacuum filtering, repeating for 3 times (i.e. first ethanol extraction, second ethanol extraction, and third ethanol extraction), mixing filtrates, distilling under reduced pressure, volatilizing ethanol, adding 5 times volume of drinking water, stirring and concentrating on a vacuum rotary instrument with water bath constant temperature of 60 deg.C, concentrating to the same weight as the total weight of the raw medicinal materials, and bottling in 100ml plastic spray bottle. In all working links of the process preparation of the traditional Chinese medicine spray, except freezing and thawing and stirring concentration links, the environment of other working links is 18-30 ℃, the relative humidity is 30-70 percent, and the cleanliness grade of a production area is a common production area. In 2016, 12 and 13 months, in a brightly bright commercial laying hen farm, a laying hen house with a high age day is selected, 100 hens with red and swollen bleeding symptoms in cloaca after anus turning over are randomly selected and isolated, and the hens are randomly divided into 2 groups of 50 hens. After the whole test group overturns the anus, the liquid medicine is sprayed at the cloaca for 3 times continuously for 5 days, and the control group is treated for 5 days according to the conventional method. After 5 days, the test group had 2 hens whose oviducts had slight inflammation, the other 48 hens were recovered to normal, the control group had 10 hens whose oviducts had slight inflammation, 3 hens whose salpingitis was not improved, and the other 37 hens were recovered to normal, and the beneficial effects of the present invention were obtained.
< example 5>
A traditional Chinese medicine spray for preventing and treating hen salpingitis by cloaca administration comprises the following medicinal materials in parts by weight: 35 parts of pine needle, 20 parts of astragalus, 20 parts of cyrtomium rhizome, 12 parts of loquat leaf, 10 parts of dandelion, 3 parts of agilawood and 2 parts of gelsemium elegans, and the selected medicinal materials are cleaned, dried and crushed into 100-mesh medicinal powder. Mixing the pulverized medicinal powder with appropriate amount of boiling water, stirring to obtain paste, and rapidly freezing the paste with high temperature at-25 deg.C for 24 hr; freezing for 24 hr, taking out the pasty Chinese medicinal powder, and thawing at 25 deg.C. Mixing the pasty Chinese medicinal powder subjected to freeze thawing treatment with 95% ethanol solution at a mass ratio of 1:3, leaching at room temperature for 3h, vacuum filtering, repeating for 3 times (i.e. first ethanol extraction, second ethanol extraction, and third ethanol extraction), mixing filtrates, distilling under reduced pressure, volatilizing ethanol, adding 5 times volume of drinking water, stirring and concentrating on a vacuum rotary instrument with water bath constant temperature of 60 deg.C, concentrating to the same weight as the total weight of the raw medicinal materials, and bottling in 100ml plastic spray bottle. In all working links of the process preparation of the traditional Chinese medicine spray, except freezing and thawing and stirring concentration links, the environment of other working links is 18-30 ℃, the relative humidity is 30-70 percent, and the cleanliness grade of a production area is a common production area. In 27 th month in 2017, in a trial chicken farm of animal science and technology institute of Guangxi university, a Guangxi Murray chicken breeding henhouse with an laying rate of 51% just after the onset of laying is selected in the farm, 100 breeding hens with red swelling and bleeding symptoms in cloaca after anus turning are randomly selected and isolated, and the breeding hens are randomly divided into 2 groups, and 50 breeding hens in each group. After the whole test group overturns the anus, the liquid medicine is sprayed at the cloaca for 3 times continuously for 5 days, and the control group is treated for 5 days according to the conventional method. After 5 days, the test group had 3 breeding hens with slight inflammation in the oviduct, the remaining 47 breeding hens recovered to be normal, the control group had 9 breeding hens with slight inflammation in the oviduct, 2 breeding hens were not improved in the oviduct, and the remaining 39 breeding hens recovered to be normal, so that the beneficial effect of the invention is achieved.
< example 6>
A traditional Chinese medicine spray for preventing and treating hen salpingitis by cloaca administration comprises the following medicinal materials in parts by weight: 35 parts of pine needle, 20 parts of astragalus, 20 parts of cyrtomium rhizome, 12 parts of loquat leaf, 10 parts of dandelion, 3 parts of agilawood and 2 parts of gelsemium elegans, and the selected medicinal materials are cleaned, dried and crushed into 100-mesh medicinal powder. Mixing the pulverized medicinal powder with appropriate amount of boiling water, stirring to obtain paste, and rapidly freezing the paste with high temperature at-25 deg.C for 24 hr; freezing for 24 hr, taking out the pasty Chinese medicinal powder, and thawing at 25 deg.C. Mixing the pasty Chinese medicinal powder subjected to freeze thawing treatment with 95% ethanol solution at a mass ratio of 1:3, leaching at room temperature for 3h, vacuum filtering, repeating for 3 times (i.e. first ethanol extraction, second ethanol extraction, and third ethanol extraction), mixing filtrates, distilling under reduced pressure, volatilizing ethanol, adding 5 times volume of drinking water, stirring and concentrating on a vacuum rotary instrument with water bath constant temperature of 60 deg.C, concentrating to the same weight as the total weight of the raw medicinal materials, and bottling in 100ml plastic spray bottle. In all working links of the process preparation of the traditional Chinese medicine spray, except freezing and thawing and stirring concentration links, the environment of other working links is 18-30 ℃, the relative humidity is 30-70 percent, and the cleanliness grade of a production area is a common production area. In 27 months in 2017, a chicken farm is tested at the institute of animal science and technology of Guangxi university, a Guangxi Murray chicken breeding house in the egg laying peak period is selected in the farm, 100 breeding hens with the symptoms of red swelling and bleeding in cloacal cavities after anus turning over are randomly selected and isolated, and the breeding hens are randomly divided into 2 groups, and 50 breeding hens are arranged in each group. After the whole test group overturns the anus, the liquid medicine is sprayed at the cloaca for 3 times continuously for 5 days, and the control group is treated for 5 days according to the conventional method. After 5 days, the test group had 1 breeding hen with slight inflammation in the oviduct, the rest 49 breeding hens recovered to be normal, the control group had 8 breeding hens with slight inflammation in the oviduct, 2 breeding hens were not improved in the oviduct, and the rest 40 breeding hens recovered to be normal, so that the beneficial effect of the invention is achieved.
< example 7>
A traditional Chinese medicine spray for preventing and treating hen salpingitis by cloaca administration comprises the following medicinal materials in parts by weight: 35 parts of pine needle, 20 parts of astragalus, 20 parts of cyrtomium rhizome, 12 parts of loquat leaf, 10 parts of dandelion, 3 parts of agilawood and 2 parts of gelsemium elegans, and the selected medicinal materials are cleaned, dried and crushed into 100-mesh medicinal powder. Mixing the pulverized medicinal powder with appropriate amount of boiling water, stirring to obtain paste, and rapidly freezing the paste with high temperature at-25 deg.C for 24 hr; freezing for 24 hr, taking out the pasty Chinese medicinal powder, and thawing at 25 deg.C. Mixing the pasty Chinese medicinal powder subjected to freeze thawing treatment with 95% ethanol solution at a mass ratio of 1:3, leaching at room temperature for 3h, vacuum filtering, repeating for 3 times (i.e. first ethanol extraction, second ethanol extraction, and third ethanol extraction), mixing filtrates, distilling under reduced pressure, volatilizing ethanol, adding 5 times volume of drinking water, stirring and concentrating on a vacuum rotary instrument with water bath constant temperature of 60 deg.C, concentrating to the same weight as the total weight of the raw medicinal materials, and bottling in 100ml plastic spray bottle. In all working links of the process preparation of the traditional Chinese medicine spray, except freezing and thawing and stirring concentration links, the environment of other working links is 18-30 ℃, the relative humidity is 30-70 percent, and the cleanliness grade of a production area is a common production area. In 27 days 2 months in 2017, in a trial chicken farm of animal science and technology college of Guangxi university, a Guangxi Ma chicken breed chicken house in the high-age stage is selected in the farm, 100 breeding chickens with the symptoms of red swelling and bleeding in cloacal cavities after turning over the anus are randomly selected and isolated, and are randomly divided into 2 groups, and each group comprises 50 breeding chickens. After the whole test group overturns the anus, the liquid medicine is sprayed at the cloaca for 3 times continuously for 5 days, and the control group is treated for 5 days according to the conventional method. After 5 days, the test group had 2 breeding hens with slight inflammation in their oviducts, the other 48 breeding hens recovered to be normal, the control group had 10 breeding hens with slight inflammation in their oviducts, 3 breeding hens did not improve their salpingitis, and the other 37 breeding hens recovered to be normal, thus obtaining the beneficial effects of the invention.
< example 8>
A traditional Chinese medicine spray for preventing and treating hen salpingitis by cloaca administration comprises the following medicinal materials in parts by weight: 30 parts of pine needle, 25 parts of astragalus, 25 parts of cyrtomium rhizome, 15 parts of loquat leaf, 10 parts of dandelion, 5 parts of agilawood and 2.5 parts of gelsemium elegans, and the selected medicinal materials are cleaned, dried and crushed into 100-mesh medicinal powder. Mixing the pulverized medicinal powder with appropriate amount of boiling water, stirring to obtain paste, and rapidly freezing the paste with high temperature at-25 deg.C for 24 hr; freezing for 24 hr, taking out the pasty Chinese medicinal powder, and thawing at 25 deg.C. Mixing the pasty Chinese medicinal powder subjected to freeze thawing treatment with 95% ethanol solution at a mass ratio of 1:3, leaching at room temperature for 3h, vacuum filtering, repeating for 3 times (i.e. first ethanol extraction, second ethanol extraction, and third ethanol extraction), mixing filtrates, distilling under reduced pressure, volatilizing ethanol, adding 5 times volume of drinking water, stirring and concentrating on a vacuum rotary instrument with water bath constant temperature of 60 deg.C, concentrating to the same weight as the total weight of the raw medicinal materials, and bottling in 100ml plastic spray bottle. In all working links of the process preparation of the traditional Chinese medicine spray, except freezing and thawing and stirring concentration links, the environment of other working links is 18-30 ℃, the relative humidity is 30-70 percent, and the cleanliness grade of a production area is a common production area. In 2017, 17 days in 3 months, a chicken breeding house of Xinchengxian county Runhua stockbreeding Limited liability company in the city of visions is selected, 100 breeding hens which are just opened to produce and have laying rate of 48 percent are randomly selected and isolated, and the breeding hens are randomly divided into 2 groups, and each group comprises 50 breeding hens. After the whole test group overturns the anus, the liquid medicine is sprayed at the cloaca for 3 times continuously for 5 days, and the control group is treated for 5 days according to the conventional method. After 5 days, the test group had 3 breeding hens with slight inflammation in the oviduct, the remaining 47 breeding hens recovered to be normal, the control group had 11 breeding hens with slight inflammation in the oviduct, 4 breeding hens were not improved in the oviduct, and the remaining 35 breeding hens recovered to be normal, so that the beneficial effect of the invention is achieved.
< example 9>
A traditional Chinese medicine spray for preventing and treating hen salpingitis by cloaca administration comprises the following medicinal materials in parts by weight: 30 parts of pine needle, 25 parts of astragalus, 25 parts of cyrtomium rhizome, 15 parts of loquat leaf, 10 parts of dandelion, 5 parts of agilawood and 2.5 parts of gelsemium elegans, and the selected medicinal materials are cleaned, dried and crushed into 100-mesh medicinal powder. Mixing the pulverized medicinal powder with appropriate amount of boiling water, stirring to obtain paste, and rapidly freezing the paste with high temperature at-25 deg.C for 24 hr; freezing for 24 hr, taking out the pasty Chinese medicinal powder, and thawing at 25 deg.C. Mixing the pasty Chinese medicinal powder subjected to freeze thawing treatment with 95% ethanol solution at a mass ratio of 1:3, leaching at room temperature for 3h, vacuum filtering, repeating for 3 times (i.e. first ethanol extraction, second ethanol extraction, and third ethanol extraction), mixing filtrates, distilling under reduced pressure, volatilizing ethanol, adding 5 times volume of drinking water, stirring and concentrating on a vacuum rotary instrument with water bath constant temperature of 60 deg.C, concentrating to the same weight as the total weight of the raw medicinal materials, and bottling in 100ml plastic spray bottle. In all working links of the process preparation of the traditional Chinese medicine spray, except freezing and thawing and stirring concentration links, the environment of other working links is 18-30 ℃, the relative humidity is 30-70 percent, and the cleanliness grade of a production area is a common production area. In 2017, 3 and 17 days, a chicken breeding farm of Limited liability company of Xinchengxian county Runhua stockbreeding is selected in Nein City, 100 breeding hens in Nandan Yao chicken breeding house in egg laying peak period are randomly selected and isolated, and the breeding hens are randomly divided into 2 groups, and each group comprises 50 breeding hens. After the whole test group overturns the anus, the liquid medicine is sprayed at the cloaca for 3 times continuously for 5 days, and the control group is treated for 5 days according to the conventional method. After 5 days, the test group had 2 breeding hens with slight inflammation in their oviducts, the other 48 breeding hens recovered to be normal, the control group had 12 breeding hens with slight inflammation in their oviducts, 5 breeding hens did not improve their salpingitis, and the other 33 breeding hens recovered to be normal, thus obtaining the beneficial effects of the invention.
< example 10>
A traditional Chinese medicine spray for preventing and treating hen salpingitis by cloaca administration comprises the following medicinal materials in parts by weight: 30 parts of pine needle, 20 parts of astragalus, 20 parts of cyrtomium rhizome, 10 parts of loquat leaf, 10 parts of dandelion, 2 parts of agilawood and 2 parts of gelsemium elegans, and the selected medicinal materials are cleaned, dried and crushed into 100-mesh medicinal powder. Mixing the pulverized medicinal powder with appropriate amount of boiling water, stirring to obtain paste, and rapidly freezing the paste with high temperature at-25 deg.C for 24 hr; freezing for 24 hr, taking out the pasty Chinese medicinal powder, and thawing at 25 deg.C. Mixing the pasty Chinese medicinal powder subjected to freeze thawing treatment with 95% ethanol solution at a mass ratio of 1:3, leaching at room temperature for 3h, vacuum filtering, repeating for 3 times (i.e. first ethanol extraction, second ethanol extraction, and third ethanol extraction), mixing filtrates, distilling under reduced pressure, volatilizing ethanol, adding 5 times volume of drinking water, stirring and concentrating on a vacuum rotary instrument with water bath constant temperature of 60 deg.C, concentrating to the same weight as the total weight of the raw medicinal materials, and bottling in 100ml plastic spray bottle. In all working links of the process preparation of the traditional Chinese medicine spray, except freezing and thawing and stirring concentration links, the environment of other working links is 18-30 ℃, the relative humidity is 30-70 percent, and the cleanliness grade of a production area is a common production area. In 2017, 17 days in 3 months, a chicken breeding farm of Limited liability company of Xinchengxing county-Hua stockbreeding in Nein city is selected, a chicken breeding house of Nandan Yao chicken at a high age stage is selected in the farm, 100 breeding hens with red swelling and bleeding symptoms in cloaca after anus turning are randomly selected and isolated, and the breeding hens are randomly divided into 2 groups, and each group comprises 50 breeding hens. After the whole test group overturns the anus, the liquid medicine is sprayed at the cloaca for 3 times continuously for 5 days, and the control group is treated for 5 days according to the conventional method. After 5 days, the test group had 4 breeding hens with slight inflammation in their oviducts, the remaining 46 breeding hens recovered to normal, the control group had 12 breeding hens with slight inflammation in their oviducts, 5 breeding hens did not improve their salpingitis, and the remaining 33 breeding hens recovered to normal, and the beneficial effects of the invention were achieved.
The traditional Chinese medicine spray for preventing and treating the salpingitis of the hens by the cloacal administration mode adopts a pure traditional Chinese medicine preparation, has mild medicine property and no irritation to the hens, effectively treats the salpingitis of the hens at each stage of the laying period, improves the production performance of the hens, is administered through the cloacal, is absorbed through intestinal mucosa, does not damage livers, relieves the irritation of the medicines to gastrointestinal tracts, improves the blood concentration and the bioavailability of the medicines, changes the traditional using method of the traditional Chinese medicines in the field of poultry production, obviously improves the extraction rate of effective components by the extraction of the traditional Chinese medicines through freeze thawing and organic extraction technology, has stable medicine effect and lasting effect, and has the characteristics of environmental protection, small toxic and side effects, avoiding the damage to the livers and the intestines and stomach of the hens and improving the production performance of the hens.
While embodiments of the invention have been described above, it is not limited to the applications set forth in the description and the embodiments, which are fully applicable to various fields of endeavor for which the invention may be embodied with additional modifications as would be readily apparent to those skilled in the art, and the invention is therefore not limited to the details given herein and to the embodiments shown and described without departing from the generic concept as defined by the claims and their equivalents.
Claims (7)
1. A traditional Chinese medicine spray for preventing and treating hen salpingitis by cloaca administration is characterized by being prepared by the following steps: firstly, selecting traditional Chinese medicinal materials such as pine needle, astragalus, cyrtomium rhizome, loquat leaf, dandelion, agilawood and gelsemium, then cleaning, drying, mixing and crushing, adding boiling water, stirring into pasty traditional Chinese medicine powder, freezing and thawing, carrying out first alcohol extraction, carrying out second alcohol extraction, carrying out third alcohol extraction, combining filtrates, removing ethanol, adding drinking water, stirring, concentrating, and finally filling to obtain the traditional Chinese medicine composition;
wherein, the traditional Chinese medicine components are as follows by weight: 30-35 parts of pine needle, 20-25 parts of astragalus membranaceus, 20-25 parts of cyrtomium rhizome, 10-15 parts of loquat leaf, 10-15 parts of dandelion, 2-6 parts of agilawood and 2-6 parts of gelsemium elegans.
2. The traditional Chinese medicine spray for preventing and treating salpingitis of hens by cloacal administration according to claim 1, wherein in all working links of the process preparation of the traditional Chinese medicine spray, except for freezing and thawing and stirring concentration links, the environment of other working links is 18-30 ℃, the relative humidity is 30% -70%, and the cleanliness of a production area is a common production area.
3. The traditional Chinese medicine spray for preventing and treating salpingitis of hens by cloacal administration according to claim 1, wherein the traditional Chinese medicine components are required to be crushed into powder with the particle size of 100 meshes.
4. The traditional Chinese medicine spray for preventing and treating salpingitis of hens by cloacal administration according to claim 3, wherein the freeze-thawing process of the medicinal powder comprises the following steps: adding boiling water into the medicinal powder, stirring to obtain paste, quickly freezing the paste at-25 deg.C for 24 hr, and thawing at 25 deg.C.
5. The traditional Chinese medicine spray for preventing and treating salpingitis of hens by cloacal administration according to claim 1, wherein the specific steps of the first alcohol extraction, the second alcohol extraction and the third alcohol extraction are as follows: mixing the pasty Chinese medicinal powder subjected to freeze thawing treatment with 95% ethanol solution at a mass ratio of 1:3, leaching at room temperature for 3h, vacuum filtering, repeating the operations for the second and third repeated ethanol extraction, mixing the filtrates, and distilling under reduced pressure to remove ethanol.
6. The traditional Chinese medicine spray for preventing and treating salpingitis of hens by cloacal administration according to claim 5, wherein the steps of removing ethanol and adding drinking water for stirring and concentrating are as follows: adding 5 times volume of drinking water into the ethanol extractive solution, stirring and concentrating in a vacuum rotary instrument with water bath constant temperature of 60 deg.C, concentrating until the weight of the medicinal liquid is the same as the total weight of the Chinese medicinal materials, and stopping concentration.
7. The traditional Chinese medicine spray for preventing and treating salpingitis of hens by cloacal administration according to claim 1, wherein a plastic spray bottle with the volume of 100ml is selected for filling in the filling process.
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| 自拟中药方治疗蛋鸡输卵管炎的试验;王钢;《上海畜牧兽医通讯》;20071231(第6期);第41页 * |
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Denomination of invention: Traditional Chinese medicine spray for prevention and treatment of salpingitis in hens by cloacal administration Effective date of registration: 20230103 Granted publication date: 20210105 Pledgee: Laiwu branch of China Postal Savings Bank Co.,Ltd. Pledgor: SHANDONG JINZHUJI PHARMACEUTICALS Co.,Ltd. Registration number: Y2023980030083 |