CN107518418A - Application of the dietary fiber as metabolism regulators - Google Patents
Application of the dietary fiber as metabolism regulators Download PDFInfo
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- CN107518418A CN107518418A CN201611176478.5A CN201611176478A CN107518418A CN 107518418 A CN107518418 A CN 107518418A CN 201611176478 A CN201611176478 A CN 201611176478A CN 107518418 A CN107518418 A CN 107518418A
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- dietary fiber
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- fiber
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Classifications
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- A—HUMAN NECESSITIES
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- A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
- A23F3/00—Tea; Tea substitutes; Preparations thereof
- A23F3/06—Treating tea before extraction; Preparations produced thereby
- A23F3/14—Tea preparations, e.g. using additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A61K31/716—Glucans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/718—Starch or degraded starch, e.g. amylose, amylopectin
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/733—Fructosans, e.g. inulin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/734—Alginic acid
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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Abstract
The present invention relates to food technology field, discloses application of the dietary fiber as metabolism regulators in metabolic disorder crowd, and the dietary fiber amount of being orally ingested of one day is 10 50 grams/people.Present invention also offers the edible formulation of four as dietary fiber metabolism regulators kind, the i.e. solid-state food rich in dietary fiber, solid beverage, alternative meal and tea beverage.The dietary fiber metabolism regulators of the present invention effectively can prevent or mitigate the incidence of disease and the state of an illness of overnutrition, obesity, cardiovascular and cerebrovascular disease, diabetes etc., have good applied value and market prospects.
Description
Technical field
The present invention relates to food and field of pharmaceutical technology, and in particular to application of the dietary fiber as metabolism regulators.
Background technology
Dietary fiber refers to can not be in the edible vegetable ingredients and its similar material that human small intestine digests and assimilates
Summation, mainly including cellulose, hemicellulose, pectin and hydrocolloid mass, such as natural gum, algal polysaccharides composition；In addition
Also include lignin contained in plant cell wall；The material not decomposed by human digestive enzymes, as resistant starch, resistance are pasted
Essence, resistance oligosaccharide, modified cellulose, clayey, oligosaccharides and a small amount of Related Component, such as paraffin paper, cutin, suberin.According to
Its dissolubility in water is divided into soluble dietary fiber (SDF) and insoluble dietary fiber (IDF).Soluble dietary fiber bag
The hydrocolloid mass such as pectin and part hemicellulose are included, insoluble dietary fiber (IDF) includes cellulose, lignin and part
Hemicellulose.
Dietary fiber is a kind of edible vegetable ingredients, rather than animal component, have relax bowel, adjustment control
One or more physiological functions such as blood sugar concentration, reducing blood lipid.Increasing evidence shows that dietary fiber is to maintain health
One of composition needed by human.With increasing substantially for living standard, there occurs deep change for the diet structure of people.Drink
Food structure so results in dietary fiber insufficiency of intake from being changed into present based on flour and rice and meat based on coarse food grain.Research
It is that diabetes B is due to human body to insulin an important factor for maintaining human insulin normal sensitivity to show dietary fiber
Sensitiveness reduce caused by, rather than caused by insufficient insulin, the insufficiency of intake of dietary fiber can cause human pancreatic islet
Plain sensitiveness declines, and insulin resistance occurs, causes diabetes B occurred frequently.According to investigation, before Chinese the eighties and now
Compare, the illness rates of diabetes is higher than 11% from less than 1% to current, diabetes B accounting from less than 10% to current
More than 95%.The also morbidity change similar to abnormal carbohydrate metabolism appearances of disease caused by Anomalous lipid metablism and purine metabolic disturbance simultaneously
Change.
The content of the invention
In view of this, it is main to use it is an object of the invention to provide a kind of application of dietary fiber as metabolism regulators
In the crowd with metabolic disorder associated diseases.
In order to realize foregoing invention purpose, the present invention provides following technical scheme：
The invention provides dietary fiber to prepare prevention or treat application in causing by metabolic disorder the medicine of disease,
It is characterized in that：The medicine is metabolism regulators, and dietary fiber, the dietary fiber one day are rich in the metabolism regulators
The amount of being orally ingested be 10-50 grams/people.
Wherein, the metabolic disorder includes diabetes B caused by abnormal carbohydrate metabolism, hyperlipidemia caused by Anomalous lipid metablism,
At least one of hyperuricemia caused by coronary heart disease, cerebrovas-cularaccident, fatty liver, obesity, and purine metabolic disturbance.
In the present invention, the product form of the dietary fiber include rich in the powdered of dietary fiber, graininess, pasty state,
Atherosclerotic, strip, the edible article of sheet or solution shape.
Preferably, the dietary fiber metabolism regulators are a kind of solid-state food rich in dietary fiber, by dry weight, bag
Component containing following parts by weight：1~15 part of water soluble algae hydrochlorate, 5~85 parts of water insoluble dietary fibers, 1~15 part of solidification
Agent；
The water soluble algae hydrochlorate includes at least one of sodium alginate, potassium alginate and ammonium alginate；
The water insoluble dietary fiber include soy bean edible fiber powder, Herba bromi japonici dietary fiber powder, wheat edible fiber powder,
At least one of Konjak dietary fiber, corn dietary fiber and kelp dietary fiber；
The curing agent is to contain Ca2+、Mg2+、Fe2+And Zn2+In any one or a few the aqueous solution.
Preferably, the dietary fiber metabolism regulators are a kind of solid beverage rich in dietary fiber, by dry weight, bag
Component containing following parts by weight：10~30 parts of water-soluble dietary fibers, 20~80 parts of water insoluble dietary fibers, 1~70 part adds
Add agent；
The water-soluble dietary fiber gathers including inulin, resistant dextrin, FOS, oligoisomaltose, yeast β-Portugal
At least one of sugar, polydextrose, xylo-oligosaccharide and soyabean oligosaccharides；
The water insoluble dietary fiber include soy bean edible fiber powder, Herba bromi japonici dietary fiber powder, wheat edible fiber powder,
At least one of Konjak dietary fiber, corn dietary fiber and kelp dietary fiber；
The additive includes sugar, bean powder, milk powder, cocoa power, vegetable fat powder, tea powder, ground coffee, soyabean protein powder, black
Sesame cream, fruit vegetable powder, coarse cereal powder, pectin, sodium carboxymethylcellulose, sodium alginate, sodium citrate, antierythrite, xylitol, three
At least one of chlorine sucrose, essence for food, calcium gluconate, vitamin and mineral.
Preferably, the dietary fiber metabolism regulators are a kind of alternative meal rich in dietary fiber, by dry weight, comprising
The component of following parts by weight：2~20 parts of water-soluble dietary fibers, 5~50 parts of water insoluble dietary fibers, 30~90 portions of coarse cereals, 1
~40 parts of additives；
The water-soluble dietary fiber gathers including inulin, resistant dextrin, FOS, oligoisomaltose, yeast β-Portugal
At least one of sugar, polydextrose, xylo-oligosaccharide and soyabean oligosaccharides；
The water insoluble dietary fiber include soy bean edible fiber powder, Herba bromi japonici dietary fiber powder, wheat edible fiber powder,
At least one of Konjak dietary fiber, corn dietary fiber and kelp dietary fiber；
The coarse cereals include at least one of oat, naked oats, beans, the seed of jog's tears and black rice；
The additive includes sugar, bean powder, milk powder, cocoa power, vegetable fat powder, tea powder, ground coffee, soyabean protein powder, black
Sesame cream, fruit vegetable powder, coarse cereal powder, pectin, sodium carboxymethylcellulose, sodium alginate, sodium citrate, antierythrite, xylitol, three
At least one of chlorine sucrose, essence for food, calcium gluconate, vitamin and mineral.
Preferably, the dietary fiber metabolism regulators are a kind of tea beverage rich in dietary fiber, by dry weight, comprising
The component of following parts by weight：30~80 parts of water-soluble dietary fibers, 1~70 part of additive；
The water-soluble dietary fiber gathers including inulin, resistant dextrin, FOS, oligoisomaltose, yeast β-Portugal
At least one of sugar, polydextrose, xylo-oligosaccharide and soyabean oligosaccharides；
It is fine that the additive includes sugar, bean powder, milk powder, cocoa power, vegetable fat powder, tea powder, ground coffee, pectin, carboxymethyl
Tie up plain sodium, sodium alginate, sodium citrate, antierythrite, xylitol, Sucralose, essence for food, calcium gluconate, dimension life
At least one of element and mineral matter.
Compared with prior art, the advantage of the invention is that：
1) present invention provides new safer and more effective selection for the crowd of metabolic disorder.The dietary fiber of traditional concept
It is that one kind is free of sugar, can not be absorbed in enteron aisle, water-swellable, the material of very strong adsorption capacity, there is satiety, profit
Intestines defaecation, promote lipid material excretion, sugar-free, absorption can not be digested in enteron aisle, being referred to as the material of human body street cleaner.This
The traditional concept of dietary fiber has been broken in invention, creatively proposes dietary fiber and is used for metabolic disorder as metabolism regulators
The application of crowd, the crowd of disease is caused especially for metabolic disorder occurred frequently at present, such as diabetes B, coronary heart disease, pain
The clinical treatment of wind, cerebrovas-cularaccident etc. and clinical auxiliary treatment, there is important clinical meaning.
2) the daily intake of present invention selection dietary fiber is not less than 10 grams, no more than 50 grams, both ensure that meals fibre
The effect of dimension should have, while also prevent the side effect that Excess free enthalpy is brought.It is anti-treat constipation be dietary fiber in use
One of universally recognized beneficial functions, it makes moisture content therein be not easy to be absorbed, stimulates enterocinesia by water suction volume expansion
So as to reduce food residence time in enteron aisle, dietary fiber through bacterial fermentation, directly absorbs the moisture content in fiber in big enteral,
Stool is softened, and then produce defecating feces excretion.But in actual use, people, which but have ignored dietary fiber, causes the pair of constipation
Effect.When the intake of dietary fiber is big, constipation, abdominal distension, stomachache can be produced, more rare side effect, which has, forms fiber in enteron aisle
Coprolite causes intestinal obstruction, defaecation possessed with dietary fiber itself and the anti-opposite effect to treat constipation occurs, and these pairs are made
Occurrence rate is higher in the patient to be become thin used in the elderly or extreme.The main reason for causing these side effects is due to dietary fiber
Enterocinesia stimulation to enteron aisle more than colon is stronger, and the stimulation of enterocinesia is weakened after entrance colon, makes meals
Fiber is eaten in colon dehydration, accumulation and bacterial fermentation aerogenesis, causes abdominal distension, constipation, or even form fiber coprolite and cause intestines
Obstruction.Due to dietary fiber has a low dosage intake defaecation and the intake of high dose causes the action character of constipation, therefore, this hair
Bright intake that dietary fiber is daily is controlled at 10~50 grams, then effect unobvious less than 10 grams.
3) product of the present invention can reduce the intake of high fever quantity of material.Made by the present invention using dietary fiber as raw material system
Standby product has low fat, low in calories, high dietary-fiber, homovitamin and high mineral and containing a variety of ammonia needed by human
The features such as base acid, staple food is replaced not only to overcome eating for staple food to cause the fat deposition and obesity of human body with it, while greatly
The dietary fiber of amount eats a large amount of intakes that can reduce high energy capacity material, is beneficial to overcome overnutrition and thus brings not
Good consequence.
4) intake of daily dietary fiber is made to reach efficacious doses level.Everyone daily dietary fiber food of China at present
Enter amount for 12.5 grams, the intake required daily far below human body.The present invention is creatively devised rich in dietary fiber
Solid-state food or beverage, can effectively complementary diets fiber intake deficiency, be advantageous to prevent and reduce cardiovascular and cerebrovascular disease,
The incidence of disease of tumour, diabetes, gall stone etc..
5) product of the present invention is multiple eating convenience, common formulations easy to carry, is provided more for the use of product
Easily by way of.Simple production process is cheap, is especially advantageous for marketing.
Therefore, the present invention has important clinical meaning and good application prospect.
Embodiment
The invention provides dietary fiber to prepare prevention or treat application in causing by metabolic disorder the medicine of disease,
It is characterized in that：The medicine is metabolism regulators, and dietary fiber, the dietary fiber one day are rich in the metabolism regulators
The amount of being orally ingested be 10-50 grams/people.Wherein, the metabolic disorder in the present invention includes diabetes B caused by abnormal carbohydrate metabolism,
Height caused by hyperlipidemia caused by Anomalous lipid metablism, coronary heart disease, cerebrovas-cularaccident, fatty liver, obesity, and purine metabolic disturbance
At least one of uricacidemia.
In the present invention, the product form of the dietary fiber include rich in the powdered of dietary fiber, graininess, pasty state,
Atherosclerotic, strip, sheet or solution shape edible article.
Present invention additionally comprises dietary fiber metabolism regulators and preparation method thereof.
The dietary fiber metabolism regulators are a kind of solid-state food rich in dietary fiber, by dry weight, comprising following
The component of parts by weight：1~15 part of water soluble algae hydrochlorate, 5~85 parts of water insoluble dietary fibers, 1~15 part of curing agent；It is preferred that
For 8~13 parts of water soluble algae hydrochlorates, 24~65 parts of water insoluble dietary fibers, 3~11 parts of curing agent.
The water soluble algae hydrochlorate includes at least one of sodium alginate, potassium alginate and ammonium alginate；
The water insoluble dietary fiber include soy bean edible fiber powder, Herba bromi japonici dietary fiber powder, wheat edible fiber powder,
At least one of Konjak dietary fiber, corn dietary fiber and kelp dietary fiber；
The curing agent is to contain Ca2+、Mg2+、Fe2+And Zn2+In any one or a few the aqueous solution, such as chlorination
Calcium, calcium carbonate, calcium gluconate, magnesium chloride, iron chloride, zinc chloride etc..The concentration of the curing agent is 5-200g/L, excellent
Select 10-150g/L.
Present invention additionally comprises the above-mentioned preparation method rich in dietary fiber solid-state food, comprise the following steps：First by institute
State water soluble algae hydrochlorate, water insoluble dietary fiber mixes with water, it is fine that water soluble algae hydrochlorate and water-insoluble meals are made
The aqueous mixture of dimension；In terms of weight by volume, in every liter of water, 1~50g of alginate, preferably 3~30g are added, further
For 5~20g.The obtained aqueous mixture is solidified in the aqueous solution of the curing agent again, obtains described contain
The solid-state food of water insoluble dietary fiber and water miscible alginate.
In the present invention, the above-mentioned solid-state food rich in dietary fiber can be graininess, strip, sheet or bulk.
The present invention also includes a kind of solid beverage metabolism regulators rich in dietary fiber, by dry weight, comprising following heavy
Measure the component of part：10~30 parts of water-soluble dietary fibers, 20~80 parts of water insoluble dietary fibers, 1~70 part of additive；It is preferred that
For 14~26 parts of water-soluble dietary fibers, 35~67 parts of water insoluble dietary fibers, 17~62 parts of additives.
The water-soluble dietary fiber gathers including inulin, resistant dextrin, FOS, oligoisomaltose, yeast β-Portugal
At least one of sugar, polydextrose, xylo-oligosaccharide and soyabean oligosaccharides；
The water insoluble dietary fiber include soy bean edible fiber powder, Herba bromi japonici dietary fiber powder, wheat edible fiber powder,
At least one of Konjak dietary fiber, corn dietary fiber and kelp dietary fiber；
The additive includes sugar, bean powder, milk powder, cocoa power, vegetable fat powder, tea powder, ground coffee, soyabean protein powder, black
Sesame cream, fruit vegetable powder, coarse cereal powder, pectin, sodium carboxymethylcellulose, sodium alginate, sodium citrate, antierythrite, xylitol, three
At least one of chlorine sucrose, essence for food, calcium gluconate, vitamin and mineral.
In the present invention, the preparation method rich in dietary fiber solid beverage preferably includes following steps：By described in
Water-soluble dietary fiber, water insoluble dietary fiber mix with the additive, and water-soluble dietary fiber, water-insoluble meals are made
Eat the mixture of fiber and additive；Obtained mixture is subjected to subpackage dress, obtain it is described containing water-soluble dietary fiber and
The solid beverage of water insoluble dietary fiber.
Preferably, the solid beverage is powdered, graininess.
The present invention also includes a kind of alternative meal metabolism regulators rich in dietary fiber, by dry weight, includes following weight
The component of part：2~20 parts of water-soluble dietary fibers, 5~50 parts of water insoluble dietary fibers, 30~90 portions of coarse cereals, 1~40 part adds
Add agent；Preferably 5~16 parts of water-soluble dietary fibers, 18~32 parts of water insoluble dietary fibers, 46~78 portions of coarse cereals, 4~32
Part additive.
The water-soluble dietary fiber gathers including inulin, resistant dextrin, FOS, oligoisomaltose, yeast β-Portugal
At least one of sugar, polydextrose, xylo-oligosaccharide and soyabean oligosaccharides；
The water insoluble dietary fiber include soy bean edible fiber powder, Herba bromi japonici dietary fiber powder, wheat edible fiber powder,
At least one of Konjak dietary fiber, corn dietary fiber and kelp dietary fiber；
The coarse cereals include at least one of oat, naked oats, beans, the seed of jog's tears and black rice；Preferably, the coarse cereals are pressure
Sheet form or crushing granulate or powdered form.
The additive includes sugar, bean powder, milk powder, cocoa power, vegetable fat powder, tea powder, ground coffee, soyabean protein powder, black
Sesame cream, fruit vegetable powder, coarse cereal powder, pectin, sodium carboxymethylcellulose, sodium alginate, sodium citrate, antierythrite, xylitol, three
At least one of chlorine sucrose, essence for food, calcium gluconate, vitamin and mineral.
Present invention additionally comprises the above-mentioned preparation method rich in the alternative meal of dietary fiber, comprise the following steps：Will be described water-soluble
Property dietary fiber, water insoluble dietary fiber mix with coarse cereals and additive, and water-soluble dietary fiber, water-insoluble meals are made
Fiber and coarse cereals and the mixture of additive；Obtained mixture is subjected to subpackage dress, obtained described fine containing aqueous soluble dietary
The alternative meal of solid of peacekeeping water insoluble dietary fiber.No
When edible, alternative meal is brewed with boiling water, or is eaten with water Hybrid Heating into pasty state or atherosclerotic.
The present invention also includes a kind of tea beverage metabolism regulators rich in dietary fiber, by dry weight, includes following weight
The component of part：30~80 parts of water-soluble dietary fibers, 1~70 part of additive；Preferably 42~71 parts of water-soluble dietary fibers, 27
~64 parts of additives.
The water-soluble dietary fiber gathers including inulin, resistant dextrin, FOS, oligoisomaltose, yeast β-Portugal
At least one of sugar, polydextrose, xylo-oligosaccharide and soyabean oligosaccharides；
It is fine that the additive includes sugar, bean powder, milk powder, cocoa power, vegetable fat powder, tea powder, ground coffee, pectin, carboxymethyl
Tie up plain sodium, sodium alginate, sodium citrate, antierythrite, xylitol, Sucralose, essence for food, calcium gluconate, dimension life
At least one of element and mineral matter.
Present invention additionally comprises the above-mentioned preparation method rich in dietary fiber tea beverage, comprise the following steps：Will be described water-soluble
Property dietary fiber mixes with additive, and the mixture of water-soluble dietary fiber and additive is made；Obtained mixture is carried out
Subpackage fills, and obtains the tea beverage containing water-soluble dietary fiber.
Preferably, the tea beverage is powdered, graininess or sheet.In use, the tea beverage is directly washed by water food
With.
In the present invention, sugar, bean powder, milk powder, cocoa power, vegetable fat powder, tea powder, ground coffee, soyabean protein powder, Semen sesami nigrum
Paste, fruit vegetable powder, coarse cereal powder and pectin are food material；Sodium carboxymethylcellulose, sodium alginate, sodium citrate, antierythrite, wood
Sugar alcohol, Sucralose and essence for food are food additives；Calcium gluconate, vitamin and mineral are nutrition fortifier.
Dietary fiber metabolism regulators provided by the invention are described in detail with reference to embodiment, but can not
They are interpreted as limiting the scope of the present invention.
Embodiment 1, the preparation using food fibre powder as the solid strip food of raw material
Raw material：Soy bean edible fiber powder and wheat edible fiber powder, sodium alginate, the chlorination that purity is 60~80%
Calcium.
Method：1000 grams of soy bean edible fiber powder is taken, 500 grams of wheat edible fiber powder stirs and evenly mixs, and mixture is made.Take
150 grams of sodium alginate, 10 liters of water, under stirring, sodium alginate is added to the water, and sodium alginate homogenate is made.Then exist
Under sodium alginate homogenate stirring, the mixture prepared is gradually added into, thick slurry is made.The calcium chloride water of configuration 3%
10 liters.Then the thick slurry prepared is squeezed into calcium chloride water, into strips, is taken out after its solidification, rinsed, incited somebody to action with clear water
Water leaching is dry, is packed with every bag 120 grams (weight in wet base), and storage is in case edible.
Embodiment 2, the preparation using food fibre powder as the solid granular food of raw material
Raw material：Corn dietary fiber powder and wheat edible fiber powder, sodium alginate, the chlorination that purity is 60~80%
Calcium.
Method：200 grams of corn dietary fiber powder is taken, 800 grams of wheat edible fiber powder stirs and evenly mixs, and mixture is made.Take
20 grams of sodium alginate, 10 liters of water, under stirring, sodium alginate is added to the water, and sodium alginate homogenate is made.Then in sea
Under mosanom homogenate stirring, the mixture prepared is gradually added into, thick slurry is made.The calcium chloride water 10 of configuration 2%
Rise.Then the thick slurry prepared is squeezed into calcium chloride water, into strips, takes out, rinsed with clear water, by water after its solidification
Leaching is dry, is cut into granular, is packed with every bag 120 grams (weight in wet base), storage is in case edible.
The preparation of embodiment 3, solid beverage of the present invention
Raw material：It is soy bean edible fiber powder, Herba bromi japonici dietary fiber powder, wheat edible fiber powder, inulin, resistant dextrin, low
Fructooligosaccharides, polydextrose, xylo-oligosaccharide, multivitamin mineral matter composite sheet, wherein the content of dietary fiber exists in fiber powder
Between 60~80%.
Method：Take 300 grams of soy bean edible fiber powder, 300 grams of Herba bromi japonici dietary fiber powder, 200 grams of wheat edible fiber powder, chrysanthemum
100 grams of powder, 100 grams of resistant dextrin, 100 grams of FOS, 100 grams of polydextrose, 50 grams of xylo-oligosaccharide, multivitamin mineral
5 grams of matter composite sheet, stirs and evenly mixs, mixture is made, and is packed with 20 grams every bag, and storage is in case edible.
The preparation of embodiment 4, solid beverage of the present invention
Raw material：It is corn dietary fiber powder, Herba bromi japonici dietary fiber powder, wheat edible fiber powder, inulin, resistant dextrin, low
Fructooligosaccharides, polydextrose, xylo-oligosaccharide, multivitamin mineral matter composite sheet, wherein the content of dietary fiber exists in fiber powder
Between 60~80%.
Method：Take 100 grams of corn dietary fiber powder, 600 grams of Herba bromi japonici dietary fiber powder, 100 grams of wheat edible fiber powder, chrysanthemum
50 grams of powder, 20 grams of resistant dextrin, 20 grams of FOS, 10 grams of polydextrose, 5 grams of multivitamin mineral matter composite sheet, stirring
Mix, mixture is made, is packed with 20 grams every bag, storage is in case edible.
The preparation of embodiment 5, the alternative meal of the present invention
Raw material：It is corn dietary fiber powder, Herba bromi japonici dietary fiber powder, kelp dietary fiber powder, oatmeal, naked oats piece, green
Beans piece, inulin, resistant dextrin, FOS, polydextrose, xylo-oligosaccharide, wherein multivitamin mineral matter composite sheet, fiber
The content of dietary fiber is between 60~80% in powder.
Method：Take 100 grams of corn dietary fiber powder, 100 grams of Herba bromi japonici dietary fiber powder, 80 grams of kelp dietary fiber powder, swallow
200 grams of oatmeal, 100 grams of naked oats piece, 50 grams of mung bean piece, 35 grams of inulin, 35 grams of resistant dextrin, 35 grams of FOS, polydextrose
35 grams, 15 grams of xylo-oligosaccharide, 3 grams of multivitamin mineral matter composite sheet, stir and evenly mix, mixture be made, it is close with 60 grams every bag
Package fills, and storage is in case edible.
The preparation of embodiment 6, the alternative meal of the present invention
Raw material：Corn dietary fiber powder, Herba bromi japonici dietary fiber powder, wheat edible fiber, oatmeal, naked oats piece, mung bean
Piece, inulin, resistant dextrin, FOS, multivitamin mineral matter composite sheet, wherein the content of dietary fiber exists in fiber powder
Between 60~80%.
Method：Take 50 grams of corn dietary fiber powder, 50 grams of Herba bromi japonici dietary fiber powder, 50 grams of wheat edible fiber, oatmeal
500 grams, 100 grams of naked oats piece, 10 grams of mung bean piece, 30 grams of inulin, 30 grams of resistant dextrin, 50 grams of FOS, multivitamin ore deposit
3 grams of material composite sheet, stirs and evenly mixs, mixture is made, and is packed with 60 grams every bag, and storage is in case edible.
The preparation of embodiment 7, tea beverage of the present invention
Raw material：Inulin, resistant dextrin, FOS, polydextrose, xylo-oligosaccharide, green tea powder, multivitamin mineral
Matter composite sheet.
Method：Take 100 grams of inulin, 100 grams of resistant dextrin, 100 grams of FOS, 100 grams of polydextrose, xylo-oligosaccharide 50
Gram, 100 grams of green tea powder, 5 grams of multivitamin mineral matter composite sheet, stir and evenly mix, mixture be made, with every bag of 5 grams of sealed bundles
Dress, storage is in case edible.
The preparation of embodiment 8, tea beverage of the present invention
Raw material：FOS, polydextrose, xylo-oligosaccharide, green tea powder, multivitamin mineral matter composite sheet.
Method：Take 100 grams of FOS, 100 grams of polydextrose, 100 grams of xylo-oligosaccharide, 700 grams of green tea powder, a variety of dimension lifes
Plain 5 grams of mineral matter composite sheet, stirs and evenly mixs, mixture is made, and is packed with 5 grams every bag, and storage is in case edible.
The effect of embodiment 9, diabetic's disposable food product of the present invention
Raw material：Dietary fiber solid-state food prepared by embodiment 1.
Method：The course of disease that the clinical diagnosis of participation activity is made a definite diagnosis in the public welfare activities of diabetes day is more than 2 years, year
The diabetes B patient in 45~76 years old age 80, age-sex is unlimited, no severe hepatic, kidney and gastrointestinal disease, and no constitution is excessive
It is thin and weak.120 grams of the dietary fiber solid-state food prepared using embodiment 1 is mixed thoroughly with 12 grams or 80 grams of cooked rices, as staple food, is matched somebody with somebody
With plain three dishes of a meat or fish two and one bottle of pure water；Diabetic's preprandial glucose is tested, the postprandial blood of patient is tested after eating 2 hours
Sugar.
As a result：In the case of existing treatment condition is immovable, compared with normal diet, the surveyed meal of instant meal
Preceding blood glucose is with preprandial glucose result under the conditions of normal diet without significant difference.Instant, which is eaten 120 grams, adds 12 grammeters after meal, after the meal
Blood glucose reduces significantly compared with the postprandial blood sugar surveyed after itself preprandial glucose and normal diet.Instant is eaten 120 grams plus 80 grams
After rice, there was no significant difference compared with itself preprandial glucose level for the postprandial blood sugar surveyed, but postprandial with being surveyed after normal diet
Blood glucose compares, and reduces notable.It is shown in Table 1.
Table 1, single eat influence of the dietary fiber food to blood sugar in diabetic patients index of correlation
| Case load | Preprandial glucose (mmol/l) | Postprandial blood sugar (mmol/l) | |
| Normal diet | 20 | 7.5±2.6 | 10.3±3.7 |
| Dietary fiber food adds 12 grammeter meals | 35 | 8.4±3.4* | 6.9±2.7*** |
| Dietary fiber food adds 80 grammeter meals | 25 | 8.3±3.7* | 8.2±3.5** |
* p ＞ 0.05 are not statistically significant, * * p<0.05, * * * p<0.01 has statistical significance.
Embodiment 10, product of the present invention repeatedly eat clinical observation on the therapeutic effect
Raw material：Dietary fiber solid-state food prepared by embodiment 1
Method：Diabetes B patient is made a definite diagnosis through clinical diagnosis, the course of disease was more than 2 years, the 2 type glycosurias at 52~85 years old age
Patient 60.Selected and exclusion standard is as follows：Voluntary participation experience activity simultaneously coordinates experience activity, makes a definite diagnosis diabetes B trouble
Person, for the course of disease more than 2 years, age-sex was unlimited, no severe hepatic, kidney and gastrointestinal disease, and no constitution is excessively thin and weak.Edible time 16
My god, lunch or dinner are eaten.It is edible start before continuous detection 3 days in the case of normal diet before the meal and postprandial blood sugar, daily
Survey once.It is edible to start 1 morning fasting blood-glucose of preceding survey.Start instant meal, preprandial glucose is surveyed before eating every time, after eating
Survey postprandial blood sugar within 2 hours.Morning after edible end, then survey fasting blood-glucose 1 time.80 grams of cooked rices are added when edible every time, are mixed thoroughly,
It is directly edible to be equipped with 1-3 cooking.Garnishes use meat cooking or single cooking, are added without flour, starch contour life sugared index during cooking
Foodstuff.Own control.In the case of existing treatment condition is immovable, diabetic is first in the case of normal diet
Continuous detection 3 days before the meal and postprandial blood sugar, then continuous instant eat 16 days.
As a result：With the results contrast in the case of normal diet, preprandial glucose is without significant difference.Instant, which is eaten 120 grams, to be added
After meal, there was no significant difference compared with postprandial blood sugar is horizontal with itself preprandial glucose, but the meal with being surveyed after normal diet for 80 grammeters
Blood glucose compares afterwards, significantly reduces.It is shown in Table 2.Being detected before the meal with postprandial blood sugar under the conditions of the normal diet of continuous three days, display is more
Number subject's postprandial blood sugar raises more than 2mmol/L compared with preprandial glucose.The fast food of continuous 16 days and be equipped with 80 grams of cooked rices and
Garnishes continuously detect display with postprandial blood sugar before the meal, under subject is very close with postprandial blood sugar before the meal, and preprandial glucose is in
Drop trend.It is 7.3 ± 1.6mmol/L before the experiment of subject's fasting blood-glucose, the measured value after the completion of experiment is 6.9 ± 1.7mmol/L,
There is downward trend, but be not statistically significant, may be too short relevant with edible time.There is a trier, start instant
Postprandial continuous three days preprandial glucoses are respectively 11.3,13,12mmol/L, gradually reduce afterwards, last three days of later stage are eaten
Preceding blood glucose is respectively 6.3,6.0,6.1mmol/L.
Table 2, repeatedly edible influence of the dietary fiber food to blood sugar in diabetic patients index of correlation
| Preprandial glucose (mmol/l) | Postprandial blood sugar (mmol/l) | |
| Normal diet | 7.1±1.3 | 9.3±1.8 |
| Dietary fiber food adds 80 grammeter meals | 7.9±2.4* | 8.3±1.9*** |
* p ＞ 0.05 are not statistically significant, * * * p<0.01 has statistical significance.
The influence to blood sugar in diabetic patients index of correlation is eaten for a long time in embodiment 11, product of the present invention
Raw material：The dietary fiber solid-state food of the preparation of embodiment 1, the solid beverage of the preparation of embodiment 2, embodiment 3 are made
Tea beverage prepared by standby alternative meal, embodiment 4.
Method：Make a definite diagnosis diabetic 21 to be studied, voluntary participation, using own control.Selected and exclusion standard
It is as follows：1) WHO (1999) diabetes diagnostic criterion (venous plasma) is met, at least with following thrin：(1) fasting blood
Sugar >=7.0mmol/L, (2) blood glucose random test >=11.1mmol/L, 2 hours blood glucose >=11.1mmol/L of (3) carbohydrate tolerance test.
2) FPI >=4.0mU/L.3) without the severe heart, brain, kidney, liver and enterogastric diseases.4) can adhere to edible and according to will
Ask and complete necessary blood testing.5) necessary record can be completed as requested.6) the excessively thin weak person of constitution except.It is selected to suffer from
Person detects fasting blood-glucose (FPG), postprandial blood sugar (2hPG), glycosylated hemoglobin (HBA1C), FPI (FINS) and blood
The conventional index such as fat, liver function, renal function and abdominal B-scan ultrasonography, body temperature, blood pressure, breathing, heart rate, body weight and body mass index.Experiment
First week edible normal diet, and carry out routine medication, detection daily is once before the meal and postprandial blood sugar, lunch or dinner.
Second week starts to eat dietary fiber food of the present invention, and intake is 20 grams of (dry weight)/days, meal when detection is once eaten daily
Preceding and postprandial blood sugar.Then according to blood glucose test results, medication and its dosage are adjusted, it is determined that on the basis of dietary therapy control
Therapeutic scheme, Continuous Observation 1 week.Survey edible rear postprandial blood sugar and fasting blood-glucose weekly afterwards once.It is continuous edible 3rd
The end of month checks and carries out blood testing and routine inspection once.
As a result：Observation long-term consumption dietary fiber food is to blood sugar in diabetic patients, insulin and glycosylated hemoglobin water
Flat influence.21 diabetics, in the case of existing treatment condition is immovable, the daily dietary fiber of diabetic
Supplement is taken in 20 grams (dry weights) and eaten by trimestral continuous supplementation on the basis of normal intake, before observing edible for patients
And blood glucose, insulin and glycosylated hemoglobin change after edible tri month.As a result the fasting blood of patient before dietary fiber treatment
Sugar, postprandial blood sugar, glycosylated hemoglobin are above normally, and Fasting insulin level is 5.9 ± 1.2mu/l, illustrates islet function
It is normal.After edible dietary fiber food is treated 3 months, fasting blood-glucose significantly reduces, postprandial blood sugar and glycosylated hemoglobin
Reduce substantially, FPI has no significant change.Illustrate daily dietary fiber supplement intake 20 grams (dry weights) to diabetes B
Acted on obvious clinical treatment.It is shown in Table 3.
The influence of table 3, long-term consumption dietary fiber food to blood sugar in diabetic patients index of correlation
| FPG(mmol/l) | 2hPG(mmol/l) | HbA1C (%) | FINS(mu/l) | |
| Before treatment | 9.22±2.77 | 11.08±3.22 | 8.41±1.26 | 6.25±1.11 |
| Treat March | 5.95±1.11*** | 7.26±1.48*** | 6.28±1.01*** | 6.51±1.01* |
* p ＞ 0.05 are not statistically significant, * * p<0.05, * * * p<0.01 has statistical significance.
The influence to hyperlipemic patients blood lipids is eaten for a long time in embodiment 12, product of the present invention
Raw material：The dietary fiber solid-state food of the preparation of embodiment 1, the solid beverage of the preparation of embodiment 3, embodiment 5 are made
Tea beverage prepared by standby alternative meal, embodiment 7.
Method：Make a definite diagnosis hyperlipemia 18 to be studied, voluntary participation, using own control.Inclusion criteria is as follows：
Following three at least conform to one, blood T-CHOL (TC) ﹥ 5.7mmol/L, blood triglyceride (TG) ﹥ 2.02mmol/L, it is low close
Spend lipoprotein cholesterol (LDL-C) ﹥ 3.36mmol/L.Selected patient detects blood T-CHOL, blood triglyceride, low-density lipoprotein
White cholesterol and with HDL-C (HDL-C).Test and start within first week to eat dietary fiber food of the present invention, take the photograph
It is 20 grams of (dry weight)/days to enter amount, and continuous edible 3rd the end of month checks and carries out blood testing and routine inspection once.
As a result：Influence of the observation long-term consumption dietary fiber food to hyperlipemic patients blood lipid level.18 highs fat of blood are suffered from
Person, in the case of existing treatment condition is immovable, 20 grams of the supplement intake on the basis of normal intake of daily dietary fiber
(dry weight) and blood T-CHOL (TC), blood triglyceride (TG), low-density lipoprotein after trimestral continuous supplementation is edible
White cholesterol (LDL-C) and HDL-C (HDL-C) are horizontal with eating preceding horizontal change.As a result meals are eaten
After fiber food is treated 3 months, blood T-CHOL, triglycerides and LDL-C significantly reduce, high
Density lipoprotein-cholesterol average value is also in normal range (NR).Illustrate daily dietary fiber supplement intake 20 grams (dry weights) to 2 types
There is dyslipidemia in diabetes significant clinical treatment to act on.It is shown in Table 4.
The influence of table 4, long-term consumption dietary fiber food to diabetic's blood lipids
* p ＞ 0.05 are not statistically significant, * * p<0.05, * * * p<0.01 has statistical significance.
The influence to the Patients with Fatty Liver state of an illness is eaten for a long time in embodiment 13, product of the present invention
Raw material：The dietary fiber solid-state food of the preparation of embodiment 1, the solid beverage of the preparation of embodiment 2, embodiment 3 are made
Tea beverage prepared by standby alternative meal, embodiment 4.
Method：Make a definite diagnosis Patients with Fatty Liver 15 to be studied, voluntary participation, using own control.Inclusion criteria is as follows：B
It is super to check the Patients with Fatty Liver made a definite diagnosis, no the severe heart, brain, kidney, liver and enterogastric diseases, except the excessively thin weak person of constitution.It is selected
Patient detects abdominal B-scan ultrasonography.Starting to eat dietary fiber food of the present invention, intake is 20 grams of (dry weight)/days, the continuous edible 3rd
The individual the end of month checks once.
As a result：15 selected Patients with Fatty Liver, observe daily dietary fiber and supplemented on the basis of normal intake and taken the photograph
Enter the change of 20 grams (dry weights) and the fatty liver order of severity after trimestral continuous supplementation is edible.As a result dietary fiber is controlled
Patient has mild fatty liver 8, moderate 6, severe 1 before treatment.After edible dietary fiber food is treated 3 months, moderate and again
Degree mitigation becomes apparent from.Illustrate that daily dietary fiber supplement takes in 20 grams (dry weights) and also has one to diabetes B patient fatty liver
Fixed clinical auxiliary therapeutic action.It is shown in Table 5.
The influence of table 5, long-term consumption dietary fiber food to diabetic's fatty liver
| Slightly | Moderate | Severe | |
| Before treatment | 8 | 6 | 1 |
| Treat * * in March | 13 | 2 | 0 |
* p ＞ 0.05 are not statistically significant, * * p<0.05, * * * p<0.01 has statistical significance.
The influence to Patients with Hyperuricemia serum uric acid level is eaten for a long time in embodiment 14, product of the present invention
Raw material：The dietary fiber solid-state food of the preparation of embodiment 1, the solid beverage of the preparation of embodiment 3, embodiment 5 are made
Tea beverage prepared by standby alternative meal, embodiment 7.
Method：Make a definite diagnosis Patients with Hyperuricemia 18 to be studied, voluntary participation, using own control.Inclusion criteria is such as
Under：Following three at least conform to one, blood uric acid (UA) ﹥ 450umol/L.Selected patient detects blood uric acid.Start to eat this hair
Bright dietary fiber food, intake are 20 grams of (dry weight)/days, and continuous edible 3rd the end of month checks and carries out blood testing.
As a result：Influence of the observation long-term consumption dietary fiber food to Patients with Hyperuricemia serum uric acid level.18 height
Uricacidemia patient, in the case of existing treatment condition is immovable, daily dietary fiber is mended on the basis of normal intake
Fill intake 20 grams (dry weights) and the serum uric acid level after trimestral continuous supplementation is edible and edible preceding horizontal change.Knot
After fruit eats dietary fiber food treatment 3 months, serum uric acid level has system from the near 298 ± 112umol of 558 ± 123umol
Meter learns meaning.Illustrate that daily dietary fiber supplement is taken in 20 grams (dry weights) and had extremely significantly to diabetes B patients with lipid
Clinical treatment acts on.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (7)
1. application of the dietary fiber in preparation prevention or treatment are caused the medicine of disease by metabolic disorder, it is characterised in that：Institute
It is metabolism regulators to state medicine, and dietary fiber, the dietary fiber amount of being orally ingested of one day are rich in the metabolism regulators
For 10-50 grams/people.
2. application according to claim 1, it is characterised in that the metabolic disorder includes the sugar of 2 types caused by abnormal carbohydrate metabolism
Urine disease, hyperlipidemia caused by Anomalous lipid metablism, coronary heart disease, cerebrovas-cularaccident, fatty liver, obesity, and purine metabolic disturbance institute
At least one of hyperuricemia of cause.
3. application according to claim 1, it is characterised in that the product form pattern of the dietary fiber includes being rich in meals
Eat the edible article of the powdered of fiber, graininess, pasty state, atherosclerotic, strip, sheet or solution shape.
4. application according to claim 1, it is characterised in that the metabolism regulators are solid-state food, comprising following heavy
Measure the component of part：1~15 part of water soluble algae hydrochlorate, 5~85 parts of water insoluble dietary fibers, 1~15 part of curing agent；
The water soluble algae hydrochlorate includes at least one of sodium alginate, potassium alginate and ammonium alginate；
The water insoluble dietary fiber includes soy bean edible fiber powder, Herba bromi japonici dietary fiber powder, wheat edible fiber powder, konjaku
At least one of dietary fiber, corn dietary fiber and kelp dietary fiber；
The curing agent is to contain Ca2+、Mg2+、Fe2+And Zn2+In any one or a few the aqueous solution.
5. application according to claim 1, it is characterised in that the metabolism regulators are solid beverage, comprising following heavy
Measure the component of part：10~30 parts of water-soluble dietary fibers, 20~80 parts of water insoluble dietary fibers, 1~70 part of additive；
The water-soluble dietary fiber includes inulin, resistant dextrin, FOS, oligoisomaltose, yeast beta-dextran, poly-
At least one of glucose, xylo-oligosaccharide and soyabean oligosaccharides；
The water insoluble dietary fiber includes soy bean edible fiber powder, Herba bromi japonici dietary fiber powder, wheat edible fiber powder, konjaku
At least one of dietary fiber, corn dietary fiber and kelp dietary fiber；
The additive includes sugar, bean powder, milk powder, cocoa power, vegetable fat powder, tea powder, ground coffee, soyabean protein powder, Semen sesami nigrum
Paste, fruit vegetable powder, coarse cereal powder, pectin, sodium carboxymethylcellulose, sodium alginate, sodium citrate, antierythrite, xylitol, trichlorine sugarcane
At least one of sugar, essence for food, calcium gluconate, vitamin and mineral.
6. application according to claim 1, it is characterised in that the metabolism regulators are alternative meal, include following weight
The component of part：2~20 parts of water-soluble dietary fibers, 5~50 parts of water insoluble dietary fibers, 30~90 portions of coarse cereals, 1~40 part adds
Add agent；
The water-soluble dietary fiber includes inulin, resistant dextrin, FOS, oligoisomaltose, yeast beta-dextran, poly-
At least one of glucose, xylo-oligosaccharide and soyabean oligosaccharides；
The water insoluble dietary fiber includes soy bean edible fiber powder, Herba bromi japonici dietary fiber powder, wheat edible fiber powder, konjaku
At least one of dietary fiber, corn dietary fiber and kelp dietary fiber；
The coarse cereals include at least one of oat, naked oats, beans, the seed of jog's tears and black rice；
The additive includes sugar, bean powder, milk powder, cocoa power, vegetable fat powder, tea powder, ground coffee, soyabean protein powder, Semen sesami nigrum
Paste, fruit vegetable powder, coarse cereal powder, pectin, sodium carboxymethylcellulose, sodium alginate, sodium citrate, antierythrite, xylitol, trichlorine sugarcane
At least one of sugar, essence for food, calcium gluconate, vitamin and mineral.
7. application according to claim 1, it is characterised in that the metabolism regulators are tea beverage, include following weight
The component of part：20~80 parts of water-soluble dietary fibers, 1~50 part of additive；
The water-soluble dietary fiber includes inulin, resistant dextrin, FOS, oligoisomaltose, yeast beta-dextran, poly-
At least one of glucose, xylo-oligosaccharide and soyabean oligosaccharides；
The additive includes sugar, bean powder, milk powder, cocoa power, vegetable fat powder, tea powder, ground coffee, pectin, carboxymethyl cellulose
Sodium, sodium alginate, sodium citrate, antierythrite, xylitol, Sucralose, essence for food, calcium gluconate, vitamin and
At least one of mineral matter.
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| CN108524546A (en) * | 2018-05-14 | 2018-09-14 | 东莞市圣露食品有限公司 | A kind of application of ostreae testa pulverata and resistant dextrin composition in hyperuricemia |
| CN108720029A (en) * | 2018-04-27 | 2018-11-02 | 吉林省倍减生物科技有限公司 | A kind of meal fiber tablet and preparation method thereof with antiobesity action |
| CN108968085A (en) * | 2018-09-28 | 2018-12-11 | 山东禹王生态食业有限公司 | A kind of dietary fiber meal replacement powder |
| CN110152002A (en) * | 2019-07-10 | 2019-08-23 | 鲁东大学 | A kind of composition and its application of oligoisomaltose and calcium ion antagonist |
| CN110179037A (en) * | 2019-06-04 | 2019-08-30 | 中国科学院烟台海岸带研究所 | A kind of composite dietary generation meal solid beverage and preparation method thereof |
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| CN110215520A (en) * | 2019-07-10 | 2019-09-10 | 鲁东大学 | A kind of composition and its application of oligofructose and calcium ion antagonist |
| CN110152002A (en) * | 2019-07-10 | 2019-08-23 | 鲁东大学 | A kind of composition and its application of oligoisomaltose and calcium ion antagonist |
| CN110651862A (en) * | 2019-11-21 | 2020-01-07 | 李海齐 | Oral solid beverage capable of promoting uric acid reduction after tea drinking and preparation method thereof |
| CN112868772A (en) * | 2019-11-29 | 2021-06-01 | 内蒙古伊利实业集团股份有限公司 | Fermented low-protein flavored beverage and preparation method thereof |
| WO2022001078A1 (en) * | 2020-07-03 | 2022-01-06 | 济南瑞隆安生物技术有限公司 | Flavonoid fermented product, preparation method, and application in blood sugar regulation |
| CN113116983A (en) * | 2021-02-26 | 2021-07-16 | 宁波倍益嘉生物科技有限公司 | Composition for regulating intestinal flora and reducing blood uric acid, preparation method and application thereof |
| CN115104689A (en) * | 2021-03-22 | 2022-09-27 | 南京益纤生物科技有限公司 | Solid beverage with intestinal tract adjusting function |
| CN113662198A (en) * | 2021-08-25 | 2021-11-19 | 都汇康健(成都)医疗科技有限公司 | Low-calorie blood sugar-reducing fat-reducing macromolecular dietary fiber fruity gel oral preparation |
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