CN107496604A - A kind of camellia oil nanometer emulsion oral liquid and preparation method thereof - Google Patents
A kind of camellia oil nanometer emulsion oral liquid and preparation method thereof Download PDFInfo
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- CN107496604A CN107496604A CN201710901690.1A CN201710901690A CN107496604A CN 107496604 A CN107496604 A CN 107496604A CN 201710901690 A CN201710901690 A CN 201710901690A CN 107496604 A CN107496604 A CN 107496604A
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- CN
- China
- Prior art keywords
- camellia oil
- oral liquid
- parts
- nanometer emulsion
- oil
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- 239000010495 camellia oil Substances 0.000 title claims abstract description 75
- 239000000839 emulsion Substances 0.000 title claims abstract description 56
- 239000007788 liquid Substances 0.000 title claims abstract description 55
- 238000002360 preparation method Methods 0.000 title claims description 20
- 239000008346 aqueous phase Substances 0.000 claims abstract description 26
- 239000003921 oil Substances 0.000 claims abstract description 24
- 239000004094 surface-active agent Substances 0.000 claims abstract description 24
- 239000012071 phase Substances 0.000 claims abstract description 20
- 239000004064 cosurfactant Substances 0.000 claims abstract description 17
- 239000002994 raw material Substances 0.000 claims abstract description 13
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 35
- 239000000463 material Substances 0.000 claims description 34
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 32
- 235000019198 oils Nutrition 0.000 claims description 23
- 239000000706 filtrate Substances 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 238000003756 stirring Methods 0.000 claims description 16
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 12
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 12
- 244000189799 Asimina triloba Species 0.000 claims description 11
- 235000006264 Asimina triloba Nutrition 0.000 claims description 11
- 235000009467 Carica papaya Nutrition 0.000 claims description 11
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims description 11
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims description 11
- 235000009685 Crataegus X maligna Nutrition 0.000 claims description 11
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims description 11
- 235000009486 Crataegus bullatus Nutrition 0.000 claims description 11
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims description 11
- 235000009682 Crataegus limnophila Nutrition 0.000 claims description 11
- 235000004423 Crataegus monogyna Nutrition 0.000 claims description 11
- 235000002313 Crataegus paludosa Nutrition 0.000 claims description 11
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims description 11
- 235000007164 Oryza sativa Nutrition 0.000 claims description 11
- 244000185386 Thladiantha grosvenorii Species 0.000 claims description 11
- 235000011171 Thladiantha grosvenorii Nutrition 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 11
- 235000009566 rice Nutrition 0.000 claims description 11
- 240000008397 Ganoderma lucidum Species 0.000 claims description 10
- 235000001637 Ganoderma lucidum Nutrition 0.000 claims description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 10
- 239000003513 alkali Substances 0.000 claims description 10
- 238000000855 fermentation Methods 0.000 claims description 10
- 230000004151 fermentation Effects 0.000 claims description 10
- 238000001914 filtration Methods 0.000 claims description 10
- 239000002245 particle Substances 0.000 claims description 7
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 6
- 229920001030 Polyethylene Glycol 4000 Polymers 0.000 claims description 6
- 229930003427 Vitamin E Natural products 0.000 claims description 6
- 239000008367 deionised water Substances 0.000 claims description 6
- 229910021641 deionized water Inorganic materials 0.000 claims description 6
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 6
- 238000000227 grinding Methods 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 6
- 229920000053 polysorbate 80 Polymers 0.000 claims description 6
- 238000011084 recovery Methods 0.000 claims description 6
- 235000019165 vitamin E Nutrition 0.000 claims description 6
- 229940046009 vitamin E Drugs 0.000 claims description 6
- 239000011709 vitamin E Substances 0.000 claims description 6
- 108010059892 Cellulase Proteins 0.000 claims description 5
- 229940106157 cellulase Drugs 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 5
- 235000011187 glycerol Nutrition 0.000 claims description 5
- 239000004006 olive oil Substances 0.000 claims description 5
- 235000008390 olive oil Nutrition 0.000 claims description 5
- 239000010497 wheat germ oil Substances 0.000 claims description 5
- 229940119170 jojoba wax Drugs 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 3
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- 240000000171 Crataegus monogyna Species 0.000 claims 2
- 240000007594 Oryza sativa Species 0.000 claims 2
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- 239000000243 solution Substances 0.000 description 20
- 241001092040 Crataegus Species 0.000 description 9
- 241000209094 Oryza Species 0.000 description 9
- 230000036772 blood pressure Effects 0.000 description 9
- 241000700159 Rattus Species 0.000 description 8
- -1 antitumor Substances 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 239000004359 castor oil Substances 0.000 description 5
- 235000019438 castor oil Nutrition 0.000 description 5
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 5
- 229940051841 polyoxyethylene ether Drugs 0.000 description 5
- 229920000056 polyoxyethylene ether Polymers 0.000 description 5
- 230000000747 cardiac effect Effects 0.000 description 4
- 239000007908 nanoemulsion Substances 0.000 description 4
- 238000005286 illumination Methods 0.000 description 3
- 238000003475 lamination Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000004530 micro-emulsion Substances 0.000 description 3
- 206010004542 Bezoar Diseases 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 2
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- 238000010521 absorption reaction Methods 0.000 description 2
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- 230000003078 antioxidant effect Effects 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- LRFDUPNLCDXZOE-UHFFFAOYSA-N camellianin b Chemical compound OC1C(O)C(O)C(C)OC1OC1C(O)C(O)C(OC=2C=3C(=O)C=C(OC=3C=C(O)C=2)C=2C=CC(O)=CC=2)OC1CO LRFDUPNLCDXZOE-UHFFFAOYSA-N 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
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- 239000013641 positive control Substances 0.000 description 2
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- 238000013112 stability test Methods 0.000 description 2
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
- 240000001548 Camellia japonica Species 0.000 description 1
- 244000147058 Derris elliptica Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010023129 Jaundice cholestatic Diseases 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 201000005267 Obstructive Jaundice Diseases 0.000 description 1
- 235000004347 Perilla Nutrition 0.000 description 1
- 244000124853 Perilla frutescens Species 0.000 description 1
- 244000000231 Sesamum indicum Species 0.000 description 1
- 235000003434 Sesamum indicum Nutrition 0.000 description 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 1
- JAWMENYCRQKKJY-UHFFFAOYSA-N [3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-ylmethyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl]-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]methanone Chemical compound N1N=NC=2CN(CCC=21)CC1=NOC2(C1)CCN(CC2)C(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F JAWMENYCRQKKJY-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
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- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 235000018597 common camellia Nutrition 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 239000008157 edible vegetable oil Substances 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000001033 granulometry Methods 0.000 description 1
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- 230000036737 immune function Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000009830 intercalation Methods 0.000 description 1
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- 210000004185 liver Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007102 metabolic function Effects 0.000 description 1
- 238000000593 microemulsion method Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
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- 235000020824 obesity Nutrition 0.000 description 1
- IYDGMDWEHDFVQI-UHFFFAOYSA-N phosphoric acid;trioxotungsten Chemical compound O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.OP(O)(O)=O IYDGMDWEHDFVQI-UHFFFAOYSA-N 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 238000004627 transmission electron microscopy Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/06—Enzymes
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/732—Chaenomeles, e.g. flowering quince
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A—HUMAN NECESSITIES
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- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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- A—HUMAN NECESSITIES
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- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Polymers & Plastics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to medicine, food, health product technology field, more particularly to a kind of camellia oil nanometer emulsion oral liquid, it is made up of following mass parts raw material：Surfactant, cosurfactant, camellia oil, oil phase, aqueous phase；Camellia oil nanometer emulsion oral liquid outward appearance prepared by the present invention is homogeneous, and camellia oil nanometer emulsion oral liquid form is spheroidal under transmission electron microscope, is evenly distributed, average grain diameter 43nm.
Description
Technical field
The invention belongs to medicine, food, health product technology field, more particularly to a kind of camellia oil nanometer emulsion oral liquid
And preparation method thereof.
Background technology
Camellia oil is the distinctive oil tree in China, and yield is big, has original producton location advantage and trump-cards in the export of.It is rich in camellia oil
The unrighted acid that contains, reach as high as more than 85%, in addition, rich in carrotene, vitamin, squalene, camellin, saponin(e,
The active principles such as Tea Polyphenols, mineral matter, its vitamin E are several times of olive oil, and this is unnecessary in human body with regard to that can effectively reduce
Cholesterol, prevent rubbish toxin from being deposited in vascular wall, and powerful antioxidant vitamin E can keep blood vessel elasticity, throughout the year
Eat camellia oil and can substantially reduce cardiovascular and cerebrovascular diseases risk, strengthen internal system function, camellia oil can improve organism
Metabolic function.Result of study shows that after Healthy People eats camellia oil, internal glucose content can reduce by 12%.Institute
The best edible oil for preventing and controlling diabetes is turned into current camellia oil.In addition, camellia oil has anti-oxidant, antitumor, drop
The effects such as blood pressure, hypoglycemic, anti-inflammatory, antibacterial, promotion percutaneous drug absorption, anti-obstructive jaundice and protect liver, can be used as nutrition food
With, regulation immunologic function, preventing and treating obesity, Recovery, prevention of cardiovascular disease and cutaneous diseases etc..
Because camellia oil is in thick, not only sensory effects are poor, and its particle diameter is big, and dispersive property in media as well is poor, no
Beneficial to being absorbed by the body, its development and application in food, cosmetic field greatly limit.In order to improve camellia oil-dispersing property,
Be prepared into microemulsion, but emulsion intercalation method can be poor, be easily delaminated after standing for a long time, be equally difficult to improvement camellia oil
Dispersiveness, thus cause to camellia oil absorption difference, cause the waste of product.
The content of the invention
The present invention is in order to solve the above technical problems, provide a kind of camellia oil nanometer emulsion oral liquid and preparation method thereof.
Realized particular by following technical scheme：
A kind of camellia oil nanometer emulsion oral liquid, it is made up of following mass parts raw material：Surfactant 30-60 parts, help surface
Activating agent 0.5-20 parts, camellia oil 0.1-15 parts, oil phase 1-10 parts, aqueous phase 20-70 parts.
Further, described camellia oil nanometer emulsion oral liquid, it is made up of following mass parts raw material：Surfactant 57-60
Part, cosurfactant 3-7 parts, camellia oil 7-12 parts, oil phase 7-9 parts, aqueous phase 50-55 parts.
Further, described surfactant, be castor oil polyoxyethylene ether, rilanit special APEO, tween-
80 according to mass ratio 31.3-32.7:18.6-19:3.5-4.2 mix.
Further, described cosurfactant, it is according to quality by PEG-4000, glycerine, n-butanol, ethanol
Compare 3.7-4.5:1-2:0.8-1.3:7-10 is mixed.
Further, described oil phase, it is one kind or several in vitamin E oil, wheat-germ oil, olive oil, jojoba oil
Kind.
Further, described aqueous phase, including following mass parts raw material：Hawthorn 30-33 parts, Momordica grosvenori 20-23 parts, spirit
Sesame 17-20 parts, pawpaw 10-14 parts, glutinous rice root 7-10 parts.
Further, described aqueous phase, including following preparation process：
1) hawthorn, Momordica grosvenori, ganoderma lucidum, pawpaw, glutinous rice root co-grinding, addition mixed liquor 1, it is 50- that water content, which is made,
70% compound, 40-55 DEG C stands 40-55min, is fermented 3-4 days at 30-35 DEG C, obtains fermentation material, adds 3-4 times of fermentation material
The clear water of quality, 80-90 DEG C of refluxing extraction 3-4h, obtains extract solution 1；
2) alkali lye of the 1/3-1/4 times of mass of extract solution 1 is added, 40-50r/min stirring 30-50min, filtering, obtains filtrate 1；
3) ethanol of the 1/2-1/3 times of volume of filtrate 1 is added, 2-8 DEG C of standing 12-14h, filtering, obtains filtrate 2；
4) reduced-pressure backflow of filtrate 2 recovery ethanol, obtains residual solution, adds the deionized water mixing of 4-7 times of residual solution quality, both
；
Wherein, described mixed liquor 1, is the mixed liquor of cellulase, pectase, and concentration is respectively 0.03-0.1mol/L
And 0.05-0.07mol/L；
Wherein, described alkali lye is 0.5-0.7mol/L sodium hydroxide solution.
Further, described camellia oil nanometer emulsion oral liquid, including following preparation process：
1) surfactant, cosurfactant are weighed in proportion, and 50-55 DEG C is stirred, and obtains material 1；
2) oil phase mixes, and obtains material 2；
3) 20-25 DEG C, material 2, aqueous phase are added drop-wise in material 1 under the conditions of 33-40r/min, stir 2-3h, 10-12 DEG C of standing
2-3h, 18-22 DEG C, 10-20r/min stirrings 70-80min both.
Further, the particle diameter of camellia oil nanometer emulsion oral liquid is in 10-100nm.
Beneficial effects of the present invention：Camellia oil nanometer emulsion oral liquid outward appearance prepared by the present invention is homogeneous, transmission electron microscopy
Camellia oil nanometer emulsion oral liquid form is spheroidal under mirror, is evenly distributed, average grain diameter 43nm, thermostatic accelerated experiment, Qiang Guang
Exposure experiment shows, camellia oil nanometer emulsion oral liquid in -4 DEG C, 40 DEG C, 60 DEG C and relative humidity under 75% after 5d, 10d
Still uniformly, without lamination, camellia oil nanometer emulsion oral liquid also keeps uniform, existing without layering after 10000r/imn centrifuges 5min
As.
Further carry out rat model, the results showed that camellia oil nanometer emulsion oral liquid prepared by the present invention can be effective
The blood pressure for reducing rat is controlled in normal range (NR).
Embodiment
The embodiment of the present invention is described in further detail below, but the invention is not limited in these realities
Mode is applied, any improvement or replacement on the present embodiment essence spirit, it is claimed to still fall within the claims in the present invention
Scope.
Embodiment 1
A kind of camellia oil nanometer emulsion oral liquid, it is made up of following mass parts raw material：Surfactant 57g, help surface-active
Agent 3g, camellia oil 7g, oil phase 7g, aqueous phase 50g.
Described surfactant, be castor oil polyoxyethylene ether, rilanit special APEO, Tween-80 according to
Mass ratio 31.3:18.6:3.5 mix.
Described cosurfactant, it is according to mass ratio 3.7 by PEG-4000, glycerine, n-butanol, ethanol:
1:0.8:7 mix.
Described oil phase, it is that vitamin E oil, wheat-germ oil, olive oil, jojoba oil mix in equal volume.
Described aqueous phase, including following mass parts raw material：Hawthorn 30g, Momordica grosvenori 20g, ganoderma lucidum 17g, pawpaw 10g,
Glutinous rice root 7g.
Described aqueous phase, including following preparation process：
1) hawthorn, Momordica grosvenori, ganoderma lucidum, pawpaw, glutinous rice root co-grinding, addition mixed liquor 1, it is 50% that water content, which is made,
Compound, 40 DEG C stand 40min, are fermented 3 days at 30 DEG C, obtain fermentation material, add the clear water of 3 times of fermentation material quality, 80 DEG C of backflows
3h is extracted, obtains extract solution 1；
2) alkali lye of 1/3 times of mass of extract solution 1 is added, 40r/min stirring 30min, filtering, obtains filtrate 1；
3) ethanol of 1/2 times of volume of filtrate 1 is added, 2 DEG C of standing 12h, filtering, obtains filtrate 2；
4) reduced-pressure backflow of filtrate 2 recovery ethanol, obtains residual solution, adds the deionized water mixing of 4 times of residual solution quality, both
；
Wherein, described mixed liquor 1, is the mixed liquor of cellulase, pectase, concentration be respectively 0.03mol/L and
0.05mol/L；
Wherein, described alkali lye is 0.5mol/L sodium hydroxide solution.
Described camellia oil nanometer emulsion oral liquid, including following preparation process：
1) surfactant, cosurfactant are weighed in proportion, and 50 DEG C are stirred, and obtain material 1；
2) oil phase mixes, and obtains material 2；
3) 20 DEG C, material 2, aqueous phase are added drop-wise in material 1 under the conditions of 33r/min, stir 2h, 10 DEG C stand 2h, 18 DEG C, 10r/
Min stirrings 70min was both obtained.
The particle diameter of camellia oil nanometer emulsion oral liquid is in 10-100nm.
Embodiment 2
A kind of camellia oil nanometer emulsion oral liquid, it is made up of following mass parts raw material：Surfactant 58g, help surface-active
Agent 5g, camellia oil 10g, oil phase 8g, aqueous phase 53g.
Described surfactant, be castor oil polyoxyethylene ether, rilanit special APEO, Tween-80 according to
Mass ratio 31.8:18.8:3.7 mix.
Described cosurfactant, it is according to mass ratio 4.0 by PEG-4000, glycerine, n-butanol, ethanol:
1.5:1.0:8 mix.
Described oil phase, it is that vitamin E oil, wheat-germ oil, olive oil mix in equal volume.
Described aqueous phase, including following mass parts raw material：Hawthorn 31g, Momordica grosvenori 21v, ganoderma lucidum 18g, pawpaw 12g,
Glutinous rice root 8g.
Described aqueous phase, including following preparation process：
1) hawthorn, Momordica grosvenori, ganoderma lucidum, pawpaw, glutinous rice root co-grinding, addition mixed liquor 1, it is 60% that water content, which is made,
Compound, 50 DEG C stand 5min, are fermented 3.4 days at 33 DEG C, obtain fermentation material, add the clear water of 3.4 times of fermentation material quality, and 85 DEG C are returned
Stream extraction 3.4h, obtains extract solution 1；
2) alkali lye of 1/4 times of mass of extract solution 1 is added, 45r/min stirring 40min, filtering, obtains filtrate 1；
3) ethanol of 1/3 times of volume of filtrate 1 is added, 6 DEG C of standing 13h, filtering, obtains filtrate 2；
4) reduced-pressure backflow of filtrate 2 recovery ethanol, obtains residual solution, adds the deionized water mixing of 5 times of residual solution quality, both
；
Wherein, described mixed liquor 1, is the mixed liquor of cellulase, pectase, concentration be respectively 0.07ol/L and
0.06mol/L；
Described alkali lye is 0.6mol/L sodium hydroxide solution.
Described camellia oil nanometer emulsion oral liquid, including following preparation process：
1) surfactant, cosurfactant are weighed in proportion, and 53 DEG C are stirred, and obtain material 1；
2) oil phase mixes, and obtains material 2；
3) 22 DEG C, material 2, aqueous phase are added drop-wise in material 1 under the conditions of 37r/min, stir 2.3h, 11 DEG C of standing 2.3h, 20 DEG C,
15r/min stirrings 75min was both obtained.
The particle diameter of camellia oil nanometer emulsion oral liquid is in 10-100nm.
Embodiment 3
A kind of camellia oil nanometer emulsion oral liquid, it is made up of following mass parts raw material：Surfactant 60g, help surface-active
Agent 7g, camellia oil 12g, oil phase 9g, aqueous phase 55g.
Described surfactant, be castor oil polyoxyethylene ether, rilanit special APEO, Tween-80 according to
Mass ratio 32.7:19:4.2 mix.
Described cosurfactant, it is according to mass ratio 4.5 by PEG-4000, glycerine, n-butanol, ethanol:
2:1.3:10 mix.
Described oil phase, it is that wheat-germ oil, jojoba oil mix in equal volume.
Described aqueous phase, including following mass parts raw material：Hawthorn 33g, Momordica grosvenori 23g, ganoderma lucidum 20g, pawpaw 14g,
Glutinous rice root 10g.
Described aqueous phase, including following preparation process：
1) hawthorn, Momordica grosvenori, ganoderma lucidum, pawpaw, glutinous rice root co-grinding, addition mixed liquor 1, it is 70% that water content, which is made,
Compound, 55 DEG C stand 55min, are fermented 4 days at 35 DEG C, obtain fermentation material, add the clear water of 4 times of fermentation material quality, 90 DEG C of backflows
4h is extracted, obtains extract solution 1；
2) alkali lye of 1/4 times of mass of extract solution 1 is added, 50r/min stirring 50min, filtering, obtains filtrate 1；
3) ethanol of the 1/2-1/3 times of volume of filtrate 1 is added, 2-8 DEG C of standing 12-14h, filtering, obtains filtrate 2；
4) reduced-pressure backflow of filtrate 2 recovery ethanol, obtains residual solution, adds the deionized water mixing of 7 times of residual solution quality, both
；
Wherein, described mixed liquor 1, is the mixed liquor of cellulase, pectase, concentration be respectively 0.1mol/L and
0.07mol/L；
Described alkali lye is 0.7mol/L sodium hydroxide solution.
Described camellia oil nanometer emulsion oral liquid, including following preparation process：
1) surfactant, cosurfactant are weighed in proportion, and 55 DEG C are stirred, and obtain material 1；
2) oil phase mixes, and obtains material 2；
3) 25 DEG C, material 2, aqueous phase are added drop-wise in material 1 under the conditions of 40r/min, stir 3h, 12 DEG C stand 3h, 22 DEG C, 20r/
Min stirrings 80min was both obtained.
The particle diameter of camellia oil nanometer emulsion oral liquid is in 10-100nm.
Embodiment 4
The difference of embodiment 4 and embodiment 3 is to be formulated, the surfactant of embodiment 4 be castor oil polyoxyethylene ether,
Rilanit special APEO, Tween-80 are according to mass ratio 1:1:1 mixes, and preparation method is identical.
Embodiment 5
The difference of embodiment 5 and embodiment 3 is, the cosurfactant of embodiment 5 is by PEG-4000, the third three
The mass mixings such as alcohol, n-butanol, ethanol form, and preparation method is identical.
Embodiment 6
The difference of embodiment 6 and embodiment 3 is that the aqueous phase in embodiment 6 is deionized water, and preparation method is identical.
Embodiment 7
The difference of embodiment 7 and embodiment 3 is, the aqueous phase of embodiment 7 is by hawthorn, Momordica grosvenori, ganoderma lucidum, pawpaw, glutinous
Rice root co-grinding, add 4 times of clear water and decoct 3-6h, filter and obtain.
Embodiment 8
The difference of embodiment 8 and embodiment 3 is that preparation process when prepared by embodiment 8 is as follows：
1) surfactant, cosurfactant are weighed in proportion, and 55 DEG C are stirred, and obtain material 1；
2) oil phase mixes, and obtains material 2；
3) 25 DEG C, material 2, aqueous phase are added drop-wise in material 1 under the conditions of 40r/min, stir 3.5h, both.
Experimental example
1st, camellia oil nanometer emulsion oral liquid stability test
1) the camellia oil nanometer emulsion oral liquid 0.lmL prepared by Example 1-8, after 10 times of dilution, by 2% phosphotungstic acid
Dyeing, observes its form under transmission electron microscope after sample drying, separately takes camellia oil nanometer emulsion oral liquid 20mL, uses
5 times of distilled water diluting, its particle diameter is determined with laser granulometry.
2) thermostatic accelerated experiment:Take camellia oil nanometer emulsion oral liquid in -4 DEG C, 40 DEG C, 60 DEG C and relative humidity 75%
Under the conditions of preserve, after 5d, 10d, sampling observation camellia oil nanometer emulsion oral liquid outward appearance, take the camellia oil nanometer emulsion mouth
Liquid is taken in centrifuge tube, 10000r/min centrifugation 5min, observes camellia oil nanometer emulsion oral liquid.
3) strong illumination is tested:Camellia oil nanometer emulsion oral liquid is placed under 2,000 1 40001x illumination, 5d, 10d
Determine the stability of camellia oil nanometer emulsion oral liquid.
Experimental result：By above stability test result, camellia oil nanometer emulsion mouth that embodiment 1,2,3,6,7 is prepared
It is homogeneous to take liquid outward appearance, camellia oil nanometer emulsion oral liquid form is spheroidal under transmission electron microscope, is evenly distributed, average grain diameter
For 43nm, thermostatic accelerated experiment, strong illumination experiment show that camellia oil nanometer emulsion oral liquid is in -4 DEG C, 40 DEG C, 60 DEG C and phase
To humidity under 75% after 5d, 10d still uniformly, centrifuged through 10000r/imn without lamination, camellia oil nanometer emulsion oral liquid
Also kept uniformly, without lamination after 5min.
Because prepared by embodiment 4 and the surfactant used in embodiment 5, cosurfactant difference, embodiment 8
Method is different, so as to cause camellia oil nanometer emulsion oral liquid prepared by these three embodiments after 10000r/imn centrifuges 5min,
There is layering, the inhomogenous phenomenon of emulsion.
2nd, influence experiment of the camellia oil nanometer emulsion oral liquid to rat blood pressure and heart rate
Method (Wu Xujin, the preparation of Zhu's Xiao Pu perilla oil nano-emulsions and its to Hypertensive Rats of reference literature report
Influence [J] the China Veterinary Journal of blood pressure and heart rate, 2010,46,28-29.) measure camellia oil nanometer prepared by embodiment 1-8
Newborn oral liquid, control group application number CN201310230698.1 (camellia oil microemulsion and preparation method thereof) are to rats blood pressure
Influence.
By SD rats 130,13 groups are randomly divided into, every group 10, male and female half and half, is divided into normal group (normal feeding), mould
Type group (gavaging physiological saline 2.5g/kg daily), blank nano-emulsion group (gavaging blank nano-emulsion 2.25g/kg daily), embodiment
1-8 groups (gavage purple camellia oil nanometer emulsion oral liquid 2.25g/kg) daily, and control group (gavages camellia oil microemulsion 2.25g/ daily
Kg), positive controls (gavaging Bezoar pill for lowering blood pressure 0.12g/kg daily), after successive administration 15d, measurement each group rat tail artery is received
The change of contractive pressure and heart rate.Minute schedules 8:00-9:00.Cardiac index is represented with cardiac weight (mg)/body weight (g) ratio,
As a result it is as shown in table 1.
Influence of the camellia oil nanometer emulsion oral liquid of table 1 to hypertensive rat blood pressure, heart rate and cardiac index
| Group | Blood pressure (mmHg) | Heart rate (secondary/min) | Cardiac index |
| Normal group | 112±8 | 386±9 | 3.11±0.15 |
| Model group | 162±7 | 342±6 | 3.85±0.17 |
| Blank nano-emulsion group | 161±5 | 340±9 | 3.82±0.14 |
| Embodiment 1 | 110±7 | 380±8 | 3.10±0.16 |
| Embodiment 2 | 111±4 | 379±8 | 3.08±0.11 |
| Embodiment 3 | 108±5 | 380±3 | 3.09±0.06 |
| Embodiment 4 | 121±4 | 399±7 | 3.13±0.22 |
| Embodiment 5 | 130±6 | 401±3 | 3.14±0.17 |
| Embodiment 6 | 135±5 | 403±8 | 3.15±0.21 |
| Embodiment 7 | 130±8 | 400±2 | 3.14±0.15 |
| Embodiment 8 | 115±7 | 384±9 | 3.11±0.13 |
| Control group | 121±8 | 394±7 | 3.12±0.16 |
| Positive controls | 110±6 | 390±8 | 3.10±0.16 |
It is demonstrated experimentally that camellia oil nanometer emulsion oral liquid prepared by the present invention can effectively reduce the blood of rat more than
Pressure reaches normal range (NR), suitable with the effect of comparison medicine Bezoar pill for lowering blood pressure.
Claims (9)
1. a kind of camellia oil nanometer emulsion oral liquid, it is characterised in that be made up of following mass parts raw material：Surfactant 30-60
Part, cosurfactant 0.5-20 parts, camellia oil 0.1-15 parts, oil phase 1-10 parts, aqueous phase 20-70 parts.
2. camellia oil nanometer emulsion oral liquid as claimed in claim 1, it is characterised in that described camellia oil nanometer emulsion is oral
Liquid, it is made up of following mass parts raw material：Surfactant 57-60 parts, cosurfactant 3-7 parts, camellia oil 7-12 parts, oil phase
7-9 parts, aqueous phase 50-55 parts.
3. camellia oil nanometer emulsion oral liquid as claimed in claim 1, it is characterised in that described surfactant, be castor-oil plant
Oily APEO, rilanit special APEO, Tween-80 are according to mass ratio 31.3-32.7:18.6-19:3.5-4.2
Mix.
4. camellia oil nanometer emulsion oral liquid as claimed in claim 1, it is characterised in that described cosurfactant, be by
PEG-4000, glycerine, n-butanol, ethanol are according to mass ratio 3.7-4.5:1-2:0.8-1.3:7-10 is mixed.
5. camellia oil nanometer emulsion oral liquid as claimed in claim 1, it is characterised in that described oil phase, be vitamin E oil,
One or more in wheat-germ oil, olive oil, jojoba oil.
6. camellia oil nanometer emulsion oral liquid as claimed in claim 1, it is characterised in that described aqueous phase, including it is following
Mass parts raw material：Hawthorn 30-33 parts, Momordica grosvenori 20-23 parts, ganoderma lucidum 17-20 parts, pawpaw 10-14 parts, glutinous rice root 7-10 parts.
7. camellia oil nanometer emulsion oral liquid as claimed in claim 1, it is characterised in that described aqueous phase, including following preparation
Step：
1) hawthorn, Momordica grosvenori, ganoderma lucidum, pawpaw, glutinous rice root co-grinding, addition mixed liquor 1, it is 50-70%'s that water content, which is made,
Compound, 40-55 DEG C stands 40-55min, is fermented 3-4 days at 30-35 DEG C, obtains fermentation material, 3-4 times of fermentation material quality of addition
Clear water, 80-90 DEG C of refluxing extraction 3-4h, obtains extract solution 1；
2) alkali lye of the 1/3-1/4 times of mass of extract solution 1 is added, 40-50r/min stirring 30-50min, filtering, obtains filtrate 1；
3) ethanol of the 1/2-1/3 times of volume of filtrate 1 is added, 2-8 DEG C of standing 12-14h, filtering, obtains filtrate 2；
4) reduced-pressure backflow of filtrate 2 recovery ethanol, obtains residual solution, adds the deionized water mixing of 4-7 times of residual solution quality, both；
Wherein, described mixed liquor 1, is the mixed liquor of cellulase, pectase, concentration be respectively 0.03-0.1mol/L and
0.05-0.07mol/L；
Wherein, described alkali lye is 0.5-0.7mol/L sodium hydroxide solution.
8. camellia oil nanometer emulsion oral liquid as claimed in claim 1, it is characterised in that including following preparation process：
1) surfactant, cosurfactant are weighed in proportion, and 50-55 DEG C is stirred, and obtains material 1；
2) oil phase mixes, and obtains material 2；
3) 20-25 DEG C, material 2, aqueous phase are added drop-wise in material 1 under the conditions of 33-40r/min, stir 2-3h, 10-12 DEG C of standing 2-3h,
18-22 DEG C, 10-20r/min stirrings 70-80min both.
9. camellia oil nanometer emulsion oral liquid as claimed in claim 1, it is characterised in that the particle diameter of camellia oil nanometer emulsion oral liquid
In 10-100nm.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113697210A (en) * | 2021-08-18 | 2021-11-26 | 德化县祥山大果油茶有限公司 | Organic camellia oil oral liquid and preparation method thereof |
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