CN109486633A - Health liquor and tablet and preparation method thereof as made from Herba Cistanches and korean pine seed - Google Patents
Health liquor and tablet and preparation method thereof as made from Herba Cistanches and korean pine seed Download PDFInfo
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- C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
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- C12G3/04—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs
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Abstract
The invention discloses a kind of desert cistanche pine nut wine, and by Herba Cistanches, korean pine seed, appropriate rock sugar, red yeast rice, honey are auxiliary material, and being equipped with alcoholic strength is that (55-65) ± 1 (v/v) fen-flavor type white spirit is prepared for matrix.Meanwhile the by-product in preparation process can also be prepared into a kind of desert cistanche pine nut piece.The symptom of renal deficiency type patient, sign can be effectively relieved in the said goods.
Description
Technical field
The present invention relates to field of health care products, the health liquor and piece being prepared in particular to a kind of Herba Cistanches and korean pine seed
Agent.
Background technique
The liquid medicine prescription of several ingredients containing Herba Cistanches is generally bigger than normal currently on the market, and complex chemical composition, there are drugs
Between interfere with each other, unstable product quality the problems such as.Its production mostly uses heating extraction technique, to effective known to formula Chinese medicine
The heat-sensitive ingredients such as ingredient phenylpropyl alcohol alcohol glycoside, flavonoids have destruction, while also leading to volatile component fourth in Herba Cistanches
Fragrant phenol scatters and disappears.The presence of problem causes drug comprehensive therapeutic effect to decline, and causes obstacle to product standard promotion, influences to move towards modern
Change, internationalization process.The design of this preparation special process can overcome above-mentioned defective workmanship.
Country's cistanche salsa artificial planting technique is mature at present and is used widely, generate huge economic, ecology and
Social effect is the pass for influencing Herba Cistanches sand industry and developing in a healthy way by the daily fast-moving consumer goods of the high-quality of raw material of Herba Cistanches
Key.Product of the present invention is positioned as daily fast-moving consumer goods, contains fat-soluble and water-soluble two major classes for Herba Cistanches, korean pine seed
The characteristics of effective component, has developed desert cistanche pine nut wine and desert cistanche pine nut piece combination product, selects to use convenient for consumer and makes to mention
The high level of resources utilization.
Modern design awareness development level has been resolved extraction, cold heavy, container and storage etc. and restricts Production of Medicinal Liqueur efficiency and product
The technological accumulation and inheritance problem of matter.This programme design Herba Cistanches are as main component single or liquid medicine is impregnated in simple formulation, reference diafiltration
Ancient method technique takes extraction, cold heavy, standing refrigeration etc. to combine technological design, solves temperature-sensitive, volatile effective component destroys
And losing issue, increase the rate of transform of active principle.Product quality and curative effect are promoted, brief formula is conducive to promote liquid medicine product
Stability, homogeneity, validity, for product modernization, internationalization lay the foundation.
Summary of the invention
The first purpose of this invention be to provide it is a kind of using Herba Cistanches and korean pine seed as the health liquor of raw material, and its preparation
Method；
Second object of the present invention is for a kind of using Herba Cistanches and korean pine seed as the health care tablet of raw material, and its preparation
Method；
Specifically, realizing that the technical solution of first purpose of the invention is as follows:
1, a kind of formula and preparation process of desert cistanche pine nut wine, desert cistanche pine nut wine is characterized in that, is formulated as Herba Cistanches
15g-90g, korean pine seed 10-50g.Appropriate rock sugar, red yeast rice, honey are auxiliary material, using (55-65) ± 1 (v/v) fen-flavor type white spirit as base
38-52 ± 1 (v/v) vina 1000ml is made through techniques such as cold soaking, enzymatic hydrolysis, curing, secondary extraction, allotment, filterings in matter.
Specific step is as follows:
(1) raw material cleans: the dry medicine materical crude slice of Herba Cistanches (Cistanche deserticolaY.C.Ma) cleans removing impurity
It is spare；Korean pine seed is (Pinus koraiensis Sieb.et Zucc.) dry seed, removes kind of a skin, it is thick to clean rear kernel
Powder is spare at particle (aperture 1.2-2mm).
(2) it feeds intake: weighing Herba Cistanches raw material and auxiliary material in formula composition, ratio, by desertliving cistanche sheet and rock sugar coarse granule
It puts into pot for solvent extraction (belt stirrer), extraction production environment temperature control is at 10-20 DEG C.
(3) it extracts: 500ml (55-65) ± 1 (v/v) fen-flavor type white spirit, extraction time 60-90 being added into pot for solvent extraction
Day, twice, each 15min, after the completion of obtaining soaking technology, centrifugal filtration collects residue and moves to the dry standby of clean area for daily stirring
With it is spare that filtrate I must be extracted.
(4) it digests: 0.03-0.05g pectase being diluted to 10ml solution with pure water, filtrate I is added and stirs evenly,
It is digested 12-24 hours under the conditions of 20-30 DEG C of temperature, Herba Cistanches wine liquid after must digesting.
(5) it cures: Herba Cistanches wine liquid will be moved into multi-function extractor after digesting, and open wide feeding port, be heated to 80-90
DEG C, it is kept for constant temperature 1-2 hours, is then transported in pot for solvent extraction.
(6) store sth. in a cellar: the cistanche deserticola wine after curing moves in clean stainless cylinder of steel, and sealing is placed in the cellar of aeration-drying
(10 ± 5 DEG C) standings (the 12-36 month) are refrigerated, according to seasonal variations during this, cistanche deserticola wine is moved into outdoor respectively at summer, winter
Holding vessel stands 15.
(7) secondary extraction: korean pine seed kernel coarse powder being put at particle by formula rate in the cistanche deserticola wine of curing, closed,
Extraction 10-15 day, twice, each 15min is filtered after the completion for daily stirring, is collected residue and is moved to spare after clean area drying, obtains
It is spare to extract filtrate II.
(8) deploy: appropriate red yeast rice is added in extraction filtrate II, honey mixes, with 60-65 ± 1 (v/v) fen-flavor type white spirit and
Pure water deploys Alcohol degree to concentration needed for finished product, is mixed, and the desert that 1000ml alcoholic strength is (38-52) ± 1 (v/v) is made
Rong's pine nut wine.
(9) it filters: 200 mesh filter screens of desert cistanche pine nut wine after allotment is filtered, and in being filled into vial in 24 hours
Interior, packaging obtains desert cistanche pine nut wine finished product.
Realize that the technical solution of second purpose of the invention is as follows:
A kind of formula and preparation process of desert cistanche pine nut piece, desert cistanche pine nut piece are characterized in that, are formulated as Herba Cistanches 15g-
90g, korean pine seed 10-50g.Appropriate microcrystalline cellulose, magnesium stearate etc. are auxiliary material, dry with secondary extraction Herba Cistanches, korean pine seed
Residue is matrix, and 20-110 (specification 1g/ piece) is made through crushing, total mix, granulation, tabletting, packing.Specific step is as follows:
(1) take the dry residue of clean Herba Cistanches, korean pine seed by formula rate, co-grinding crosses 80 meshes, obtain Herba Cistanches,
Korean pine seed powder.
(2) microcrystalline cellulose is taken, 80 meshes are crossed；With Herba Cistanches, korean pine seed powder mixing 30min, it is uniformly mixed, must mixes
Powder.
(3) hydroxypropyl methylcellulose is taken, adds water that 3% hydroxypropyl methylcellulose aqueous solution is made, is added in above-mentioned mixed powder and makes
Softwood, the granulation of 20 meshes, dry, 20 meshes arrange, and obtain particle.
(4) magnesium stearate is taken, 80 meshes are crossed, with above-mentioned particle mixing 20min, is uniformly mixed, obtains total particle.
(5) total particle, tabletting are taken, 0.98g/ piece obtains plain piece.
(6) film coating pre-mix dose is taken, 75% ethyl alcohol is added, is configured to 8% coating solution.Plain piece coating, coating weight gain
2.0%, it is coated slice weight 1.0g/ piece.
(7) it bottles, through after the assay was approved, outer packing, as desert cistanche pine nut piece finished product.
The raw material selected in technical solution of the present invention is described as follows:
Raw material selection: its chemical component difference of different plant species is very big, its chemical constituent of the same species of different sources is also bright
Aobvious difference.Species and Genuine producing area based on this this preparation clear stipulaties formula material, guarantee the quality of raw material with this, originally to match
Square preparation characteristic.
(1) Herba Cistanches are the meat of Desert Herba Cistanches (Cistanche deserticoLa Y.C.Ma) dry zone scale leaf
Stem, the fresh medicinal material for preferably originating in Alashan Area, inner Mongolia Autonomous Region alliance or Bayannur is cleaned, cutting, medicine materical crude slice made of drying.Its
Nature and flavor are sweet, salty, temperature, have kidney-replenishing, benefiting essence-blood, the functions such as relax bowel and defecation, be clinically used for treatment the insufficiency of the kidney yang, blood and essence asthenia,
Impotence is infertile, soreness and weakness of waist and knees, and muscles and bones is powerless, the diseases such as dry constipation of intestines.
(2) korean pine seed is the dry seed of Korean pine (Pinus koraiensis Sieb.et Zucc.), is preferably originated from black
The Korean pine seeds that Longjiang province Yichun or Mudanjiang City produce.Its is sweet in flavor, and slightly warm in nature, tool is moisturized, blood-nourishing, wind-dispelling function, clinical
For treating dryness of the lung dry cough, stool is empty secret, and all public attention are dizzy, joint wind, the diseases such as wandering arthritis.
(4) white wine: main component is ethyl alcohol (98%-99%), the organic trace compounds such as acid, ester, alcohol, aldehyde (1%-
2%) and water, white wine are both solvent and effective component.White wine bitter, sweet, pungent, big heat are toxic.Have promoting blood circulation, resisting cold gas,
It is amusing middle benefit gas, row medicine gesture function, cures mainly chill numbness pain, muscle contraction urgency, thoracic obstruction, trusted subordinate's crymodynia.
(5) red yeast rice is that the mycelium of Aspergillaceae fungi monascus (Monascus purpureus Went.) parasitizes round-grained rice
Red yeast rice made of rice fermentation.Its nature and flavor is sweet, warm, nontoxic.Have reinforcing spleen to promote digestion, activating microcirculation and removing stasis medicinal function.Cure mainly eating accumulation, stomach duct and abdomen
Turgor, red white diarrhea, prolonged lochia, traumatic injury.It is used in this pharmaceutical formulation as fat-soluble pigment.
White granulated sugar, honey: it is used in this pharmaceutical formulation as sweetener, aromatic, reference food additive standard and rule
Model executes.
Dispensing information:
Herba Cistanches clinical application is with a long history, and containing a variety of pairs of human bodies beneficial to chemical component, toxicological study proves unobvious
Toxic effect.With immunological regulation, improves and remember, enhance physical strength, antifatigue, anti-aging and relax bowel and defecation and other effects.Assistant is with sea
Pine nut, red yeast rice are auxiliary material.Through special processing process, be made special fragrance, color glow, mouthfeel it is gentle and tool kidney-replenishing,
Benefiting essence-blood, wind-dispelling, the assembled alcoholic drinks of effect of relaxing bowel or drink of going with rice or bread.This product is single for characteristic with raw material, active principle basis
It is clear, stable, meet drug safety, validity, stability, uniformity requirements, be conducive to improve quality standard, is product state
Border lays the foundation.
This product is ground in Inner Mongol institute of traditional Chinese medicine clinical application many years according to kidney deficiency tcm diagnosis standard and new Chinese medicine clinic
Study carefully guidance then, worked out desert cistanche pine nut wine treatment renal deficiency type Clinical Study Protocol, design case selection method, diagnostic criteria,
It is included in standard, exclusion criteria, therapeutic scheme, observation index, determines that Syndrome Scale and ranking criterion, effect evaluation criteria, curative effect are commented
Determine the equivalent evaluation detailed rules and regulations of method, safety evaluatio.
The description of the process of technical solution of the present invention design:
(1) it technological design: is different from existing market circulation formula single water of vina health food containing Herba Cistanches and mentions, prepares work
Skill takes low temperature or room temperature (10 DEG C -30 DEG C) extracting technology, improves the effective component rate of transform and reduces and breaks to heat-sensitive ingredients
It is bad, product quality is promoted in conjunction with techniques such as enzymatic hydrolysis, cold heavy, standing refrigeration, filterings.
(2) extracting technology: research finds that part effective component of chinese medicine is thermal sensitivity and liposoluble substance in formula, extracts work
Skill design can be avoided heating extraction and damage to thermal sensitivity active principle, and low concentration alcohol solution is able to ascend liposoluble constituent
The rate of transform.So as to improve product curative effect and resource utilization.
According to effective component chemistry known to formula Chinese medicine, white wine (organic solvent) is selected to make solvent, using low temperature or
Room temperature extracting technology, it is ensured that active principle dissolves out and high-temperature water is avoided to mention and damages or be lost to it.
(3) enzymolysis process: Herba Cistanches contain pectin, tannin, oxidizable generation suspended matter or precipitating, influence desert cistanche
The clarity of wine, pectase, which is added, can promote the decomposition of pectin and tannin, precipitating, obtains after filtering and stablizes clarification former wine.
(4) curing process: former wine is heated to 80-90 DEG C and constant temperature purpose is kept to be to make pectin enzyme-deactivating while can
Play the role of removing methanol.
(5) store sth. in a cellar technique: by storing sth. in a cellar the oxidation of process, temperature become and can reduce the irritation of former wine, make its aroma of pure,
Mouthfeel is softer.Material temperature becomes, cold sink can promote the substances such as protein in former wine, starch that precipitating is precipitated, and it is clear and bright to enhance its
Degree and stability.
(6) secondary extraction: korean pine seed kernel coarse granule investment is stored sth. in a cellar in the desert cistanche former wine of ageing, room temperature extracts 10-
It 15, filters and filling as early as possible, can not be stored too long before bottling, in case korean pine seed extract aoxidizes and taste is made to become bitter.
(7) deploy filling: appropriate red yeast rice is added in extraction filtrate II, honey mixes, and red yeast rice is natural fermented fat-soluble color
Element, it is edible and have activating microcirculation and removing stasis medicinal, reinforcing spleen to promote digestion and other effects.And special fragrance, color glow, mouthfeel temperature is made by refined filtration
The desert cistanche pine nut wine of profit.
(8) the dry residue of the Herba Cistanches after secondary extraction, korean pine seed is mostly water soluble ingredient, and crystallite is added after co-grinding
Cellulose, hydroxypropyl methylcellulose are conducive to its molding and increase adhesiveness, convenient for granulation.
(9) desert cistanche pine nut plain piece made of carries out the stability and commodity property that film coating increases its finished product.
Products obtained therefrom of the present invention suggests eating method:
Health liquor, drinks 1-3 two every time, and daily lunch, supper are drunk or selected one and drink.
Health-care tablet, one time a day, 1 to 2 tablets once.
The present invention has the advantages that
1, low temperature microwave leaching technology route effectively prevent thermal sensitivity in drug, it is volatile scatter and disappear, solve active principle
The problem of rate of transform and production efficiency, technological design is reasonable, has operability under current productivity level and improves resource benefit
With rate.
2, this programme Recipe is brief, it then follows Gu Fa has regulations to abide by conjunction with the modern times.Through analysis verifying, it has finished product
Imitate into distinguish one from the other, quality is stablized, clinical efficacy is definite.Product standard can integrate with internationalization, lay the foundation to exploit market.
Etc..
Attached drawing summary description
Attached drawing 1 shows Herba Cistanches pine nut wine process flow.
Attached drawing 2 shows Herba Cistanches pine nut blade technolgy process.
Specific embodiment
Embodiment 1
1, a kind of formula and preparation process of desert cistanche pine nut wine, desert cistanche pine nut wine is characterized in that, is formulated as Herba Cistanches
15g-90g, korean pine seed 10-50g.Appropriate rock sugar, red yeast rice, honey are auxiliary material, using 55-60 ± 1 (v/v) fen-flavor type white spirit as base
38-52 ± 1 (v/v) vina 1000ml is made through techniques such as cold soaking, enzymatic hydrolysis, curing, secondary extraction, allotment, filterings in matter.
Specific step is as follows:
(1) raw material cleans: the dry medicine materical crude slice of Herba Cistanches cleans and removes the spare 60g of impurity；Korean pine seed is dry seed, is removed
Kind skin cleans rear kernel coarse powder into particle (being less than 1.2mm) spare 35g.
(2) it feeds intake: weighing Herba Cistanches raw material and auxiliary material in formula composition, ratio, by desertliving cistanche sheet and rock sugar coarse granule
It puts into pot for solvent extraction (belt stirrer), extraction production environment temperature control is at 15-20 DEG C.
(3) extract: it is 60 (v/v) fen-flavor type white spirits that 500ml alcoholic strength is added into pot for solvent extraction, and extraction time is 80,
Daily stirring twice, each 15min, after the completion of obtaining soaking technology, centrifugal filtration, collect residue move to clean area it is dry after it is spare,
It is spare that filtrate I must be extracted.
(4) it digests: 0.04g pectase being diluted to 10ml solution with pure water, filtrate I is added and stirs evenly, in 20-30
It is digested 20 hours under the conditions of DEG C temperature, Herba Cistanches wine liquid after must digesting.
(5) it cures: Herba Cistanches wine liquid will be moved into multi-function extractor after digesting, and open wide feeding port, be heated to 85 DEG C,
It is kept for constant temperature 1.5 hours, is then transported in pot for solvent extraction.
(6) store sth. in a cellar: the cistanche deserticola wine after curing moves in clean stainless cylinder of steel, and sealing is placed in the cellar of aeration-drying
10-15 DEG C of refrigeration stands 30 months, and according to seasonal variations during this, cistanche deserticola wine is moved to storage outdoors respectively at summer, winter
Tank stands 15.
(7) secondary extraction: korean pine seed kernel coarse powder being put at particle by formula rate in the cistanche deserticola wine of curing, closed,
Extraction 14 days, twice, each 15min is filtered after the completion for daily stirring, collect residue move to clean area it is dry after it is spare, must soak
It is spare to propose filtrate II.
(8) deploy: appropriate red yeast rice is added in extraction filtrate II, honey mixes, with 60 (v/v) fen-flavor type white spirits and pure water by wine
Precision number is deployed to concentration needed for finished product, is mixed, and the desert cistanche pine nut wine that 1000ml alcoholic strength is 48 (v/v) is made.
(9) it filters: 200 mesh filter screens of desert cistanche pine nut wine after allotment is filtered, and in being filled into vial in 24 hours
Interior, packaging obtains desert cistanche pine nut wine finished product.
Furthermore:
(10) the dry residue of clean Herba Cistanches, korean pine seed is taken, co-grinding crosses 80 meshes, obtains Herba Cistanches, korean pine seed powder.
(11) microcrystalline cellulose is taken, 80 meshes are crossed；With Herba Cistanches, korean pine seed powder mixing 30min, it is uniformly mixed, must mixes
Powder.
(12) hydroxypropyl methylcellulose is taken, adds water that 3% hydroxypropyl methylcellulose aqueous solution is made, is added in above-mentioned mixed powder and makes
Softwood, the granulation of 20 meshes, dry, 20 meshes arrange, and obtain particle.
(13) magnesium stearate is taken, 80 meshes are crossed, with above-mentioned particle mixing 20min, is uniformly mixed, obtains total particle.
(14) total particle, tabletting are taken, 0.98g/ piece obtains plain piece.
(15) film coating pre-mix dose is taken, 75% ethyl alcohol is added, is configured to 8% coating solution.Plain piece coating, coating weight gain
2.0%, it is coated slice weight 1.0g/ piece.
(16) it bottles, through after the assay was approved, outer packing, as desert cistanche pine nut piece finished product.
Experimental example 2: zoopery
1 experimental material
1.1 drug
1.1.1 it drug of the present invention: is prepared by embodiment 1.
1.2 experimental animals: male rat, weight 80~100g, 50, cleaning grade.
2 methods
50 male rats for being separated from milk 1 month are taken, 80~100g of weight, after subcutaneous anesthesia, back position is fixed, wherein 40 dynamic
Object surgical removal bilateral testes；Another 10 rats carry out sham-operation, i.e., only cut off skin of scrotum, do not pluck testis, stitch immediately
Close wound.Postoperative every rat skin lower injection penicillin receives 20,000 U/ only, for three days on end.
Castrated rats are randomly divided into (1) Sham-operated control group (distilled water 0.05ml/100g) by weight；(2) control group
(distilled water 0.05ml/100g)；(3) present invention group 1 (health liquor dilutes 10 times, 0.05ml/100 stomach-filling)；(4) present invention group 2
(tablet, 0.2g/100g)；(5) present invention group 3 (health liquor+tablet, 10 times of dilution, 0.05ml/100 stomach-filling, 0.2g/
100g)；Every group 10,1 time a day, continuous 28 days.Last dose for 24 hours after, animal put to death, take rapidly preputial gland, seminal vesicle and
Prostate, musculus levator ani, assay balance are precisely weighed, and are calculated organ index (mg/100g).
Realization the results are shown in Table 1.
1 castration male rat accessory sex organ's index of table
As seen from table, each organ index of control rats substantially reduces compared with sham-operation group, and of the present invention group 1,2,3 pairs is gone
Gesture rat preputial gland, musculus levator ani index, seminal vesicle and prostate index relative comparison group are significantly increased, while with wine and tablet
The present invention group 3 used simultaneously is the most significant.
Drug of the present invention has enriching yin and nourishing kidney, and QI invigorating helps effect of sun.It can be used for treating kidney-yang deficiency, nontoxic secondary work
With.
Embodiment 3, clinical trial
60 cases are collected altogether, and when daily lunch drinks health liquor 1-1.5 two, is equipped with before sleeping and takes tablet 1-2 piece, the course for the treatment of
30 days, wherein 2 (3.3%) of recovery from illness, effective 16 (26.7%), 34 (56.7%) of progress was invalid 8 (13.3%), always
Effective percentage 86.7%.The result shows that the symptom of renal deficiency type patient, sign can be effectively relieved in product of the present invention.
Recovery from illness: kidney deficiency clinical symptoms, sign disappear
Effective: kidney deficiency clinical symptoms, sign are obviously improved
Progress: kidney deficiency clinical symptoms, sign take a favorable turn
Invalid: kidney deficiency clinical symptoms, sign are not improved or aggravate.
Claims (4)
1. a kind of desert cistanche pine nut wine, which is characterized in that by Herba Cistanches 15g-90g, korean pine seed 10-50g, appropriate rock sugar, red yeast rice, bee
Honey is auxiliary material, and being equipped with alcoholic strength is that (55-65) ± 1 (v/v) fen-flavor type white spirit is prepared for matrix.
2. the preparation method of desert cistanche pine nut wine according to claim 1 comprising step:
(1) raw material cleans: it is spare to clean removing impurity for the dry medicine materical crude slice of Herba Cistanches；Korean pine seed is dry seed, removes kind of a skin, only
Kernel coarse powder is spare at particle (aperture 1.2-2mm) after choosing；
(2) it feeds intake: weighing Herba Cistanches raw material and auxiliary material in formula composition, ratio, desertliving cistanche sheet and rock sugar coarse granule are put into
In pot for solvent extraction (belt stirrer), extraction production environment temperature control is at 10-20 DEG C；
(3) it extracts: 500ml (55-65) ± 1 (v/v) fen-flavor type white spirit being added into pot for solvent extraction, extraction time is 60-90 days, often
Day stirring twice, each 15min, after the completion of obtaining soaking technology, centrifugal filtration, collect residue move to clean area it is dry after it is spare, obtain
It is spare to extract filtrate I；
(4) it digests: 0.03-0.05g pectase being diluted to 10ml solution with pure water, filtrate I is added and stirs evenly, in 20-30
It is digested 12-24 hours under the conditions of DEG C temperature, Herba Cistanches wine liquid after must digesting；
(5) it cures: Herba Cistanches wine liquid will be moved into multi-function extractor after digesting, and open wide feeding port, be heated to 80-90 DEG C,
It is kept for constant temperature 1-2 hours, is then transported in pot for solvent extraction；
(6) store sth. in a cellar: the cistanche deserticola wine after curing moves in clean stainless cylinder of steel, and sealing is placed in the cellar of aeration-drying and refrigerates
Cistanche deserticola wine is moved to storage outdoors respectively at summer, winter according to seasonal variations during this by (10 ± 5 DEG C) standings (the 12-36 month)
Tank stands 15；
(7) secondary extraction: korean pine seed kernel coarse powder is put at particle by formula rate in the cistanche deserticola wine of curing, closed, extraction
10-15 days, twice, each 15min was filtered after the completion for daily stirring, collect residue move to clean area it is dry after it is spare, must extract
Filtrate II is spare；
(8) deploy: appropriate red yeast rice is added in extraction filtrate II, honey mixes, will with 60-65 ± 1 (v/v) fen-flavor type white spirit and pure water
Alcohol degree is deployed to concentration needed for finished product, is mixed, and the desert cistanche pine nut that 1000ml alcoholic strength is (38-52) ± 1 (v/v) is made
Wine；
(9) it filters: 200 mesh filter screens of desert cistanche pine nut wine after allotment being filtered, and are filled into vial in 24 hours, wrap
Dress, obtains desert cistanche pine nut wine finished product.
3. a kind of desert cistanche pine nut piece, which is characterized in that dry with secondary extraction Herba Cistanches as stated in claim 2, korean pine seed
Residue is matrix, and appropriate microcrystalline cellulose, magnesium stearate etc. are made of auxiliary material.
4. the preparation method of desert cistanche pine nut piece according to claim 3, comprising steps of
(1) the dry residue of clean Herba Cistanches, korean pine seed is taken, co-grinding crosses 80 meshes, obtains Herba Cistanches, korean pine seed powder；
(2) microcrystalline cellulose is taken, 80 meshes are crossed；With Herba Cistanches, korean pine seed powder mixing 30min, it is uniformly mixed, obtains mixed powder；
(3) hydroxypropyl methylcellulose is taken, adds water that 3% hydroxypropyl methylcellulose aqueous solution is made, softwood processed in above-mentioned mixed powder is added,
The granulation of 20 meshes, dry, 20 meshes arrange, and obtain particle；
(4) magnesium stearate is taken, 80 meshes are crossed, with above-mentioned particle mixing 20min, is uniformly mixed, obtains total particle；
(5) total particle, tabletting are taken, 0.98g/ piece obtains plain piece；
(6) film coating pre-mix dose is taken, 75% ethyl alcohol is added, is configured to 8% coating solution；Plain piece coating, coating weight gain 2.0%.
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| CN110326701A (en) * | 2019-08-19 | 2019-10-15 | 重庆市药物种植研究所 | A kind of method of the full processing and utilization of dendrobium candidum |
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| KR20040094037A (en) * | 2003-05-01 | 2004-11-09 | 박영진 | A method for manufacturing of medicinal wine |
| CN102349650A (en) * | 2011-08-04 | 2012-02-15 | 石河子开发区神内食品有限公司 | Method for improving dissolution rate of active ingredients of Cistanche salsa |
| CN105232770A (en) * | 2015-10-08 | 2016-01-13 | 孙广军 | Kidney tonifying and spleen strengthening medicated liquor containing traditional Chinese medicines |
| CN106350405A (en) * | 2016-08-28 | 2017-01-25 | 北海古力酒业股份有限公司 | Preparation method of health wine |
| CN106473038A (en) * | 2016-09-18 | 2017-03-08 | 天津北洋百川生物技术有限公司 | A kind of Herba Cistanches health-care tablet and preparation method thereof |
| CN107118921A (en) * | 2017-07-10 | 2017-09-01 | 柴华 | A kind of brewing method of saline cistanche cynomorium songaricum health liquor |
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| KR20040094037A (en) * | 2003-05-01 | 2004-11-09 | 박영진 | A method for manufacturing of medicinal wine |
| CN102349650A (en) * | 2011-08-04 | 2012-02-15 | 石河子开发区神内食品有限公司 | Method for improving dissolution rate of active ingredients of Cistanche salsa |
| CN105232770A (en) * | 2015-10-08 | 2016-01-13 | 孙广军 | Kidney tonifying and spleen strengthening medicated liquor containing traditional Chinese medicines |
| CN106350405A (en) * | 2016-08-28 | 2017-01-25 | 北海古力酒业股份有限公司 | Preparation method of health wine |
| CN106473038A (en) * | 2016-09-18 | 2017-03-08 | 天津北洋百川生物技术有限公司 | A kind of Herba Cistanches health-care tablet and preparation method thereof |
| CN107118921A (en) * | 2017-07-10 | 2017-09-01 | 柴华 | A kind of brewing method of saline cistanche cynomorium songaricum health liquor |
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| CN110326701A (en) * | 2019-08-19 | 2019-10-15 | 重庆市药物种植研究所 | A kind of method of the full processing and utilization of dendrobium candidum |
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