CN112931869A - Camellia oleifera polyphenol composition with blood fat reducing function and preparation method thereof - Google Patents
Camellia oleifera polyphenol composition with blood fat reducing function and preparation method thereof Download PDFInfo
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- 150000008442 polyphenolic compounds Chemical class 0.000 title claims abstract description 43
- 235000013824 polyphenols Nutrition 0.000 title claims abstract description 43
- 239000008280 blood Substances 0.000 title claims abstract description 31
- 210000004369 blood Anatomy 0.000 title claims abstract description 31
- 239000000203 mixture Substances 0.000 title claims abstract description 27
- 241000526900 Camellia oleifera Species 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims description 15
- 239000010495 camellia oil Substances 0.000 claims abstract description 65
- 239000000843 powder Substances 0.000 claims abstract description 46
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 24
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims abstract description 22
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims abstract description 22
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- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims abstract description 22
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- 235000004423 Crataegus monogyna Nutrition 0.000 claims abstract description 22
- 235000002313 Crataegus paludosa Nutrition 0.000 claims abstract description 22
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims abstract description 22
- 235000003181 Panax pseudoginseng Nutrition 0.000 claims abstract description 20
- 244000131316 Panax pseudoginseng Species 0.000 claims abstract description 20
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 20
- 239000011707 mineral Substances 0.000 claims abstract description 20
- 238000001914 filtration Methods 0.000 claims abstract description 14
- 240000007164 Salvia officinalis Species 0.000 claims abstract description 13
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 12
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 12
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- 238000000034 method Methods 0.000 claims abstract description 4
- 239000006228 supernatant Substances 0.000 claims abstract description 4
- 238000000108 ultra-filtration Methods 0.000 claims abstract description 4
- 238000005406 washing Methods 0.000 claims abstract description 4
- 238000004321 preservation Methods 0.000 claims abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 23
- 241001092040 Crataegus Species 0.000 claims description 21
- 239000011259 mixed solution Substances 0.000 claims description 11
- 239000000126 substance Substances 0.000 claims description 9
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 7
- 244000132619 red sage Species 0.000 claims description 7
- 238000010992 reflux Methods 0.000 claims description 7
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- 235000010755 mineral Nutrition 0.000 claims description 3
- 239000003921 oil Substances 0.000 claims description 3
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- 230000003078 antioxidant effect Effects 0.000 abstract description 3
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- 235000021281 monounsaturated fatty acids Nutrition 0.000 abstract description 3
- 231100000915 pathological change Toxicity 0.000 abstract description 3
- 230000036285 pathological change Effects 0.000 abstract description 3
- 240000001548 Camellia japonica Species 0.000 abstract 3
- 235000018597 common camellia Nutrition 0.000 abstract 3
- 240000000171 Crataegus monogyna Species 0.000 abstract 1
- 235000015112 vegetable and seed oil Nutrition 0.000 abstract 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 10
- 208000024172 Cardiovascular disease Diseases 0.000 description 5
- 235000012000 cholesterol Nutrition 0.000 description 5
- 208000031226 Hyperlipidaemia Diseases 0.000 description 4
- 210000004204 blood vessel Anatomy 0.000 description 4
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 4
- 201000001320 Atherosclerosis Diseases 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 206010003210 Arteriosclerosis Diseases 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 206010020772 Hypertension Diseases 0.000 description 2
- 235000017276 Salvia Nutrition 0.000 description 2
- 208000011775 arteriosclerosis disease Diseases 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 201000005577 familial hyperlipidemia Diseases 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
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- 230000029087 digestion Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
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- 238000000605 extraction Methods 0.000 description 1
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- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 208000020346 hyperlipoproteinemia Diseases 0.000 description 1
- 230000037356 lipid metabolism Effects 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
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- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Inorganic Chemistry (AREA)
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Abstract
The invention discloses a tea-oil camellia polyphenol composition with a blood fat reducing function, which comprises 36-48 parts of tea-oil camellia seed oil, 2-5 parts of tea-oil camellia polyphenol, 13-21 parts of natural vitamin E, 3-5 parts of hawthorn powder, 2-6 parts of pseudo-ginseng powder, 8-12 parts of a red sage root extract and 2-3 parts of mineral dry powder. A method for preparing tea-oil tree polyphenol composition with blood lipid reducing function comprises mixing raw materials together to obtain primarily treated tea oil, heating to 70-80 deg.C, stirring for 20-30min under heat preservation; filtering and washing the primarily treated tea oil, and taking supernatant; and filtering again through an ultrafiltration membrane device to obtain the camellia oleifera polyphenol composition. The tea oil has higher content of monounsaturated fatty acid and also has the function of reducing blood fat; the tea oil is rich in tea polyphenol with remarkable antioxidation, the tea polyphenol in the tea oil has the functions of reducing blood fat, resisting oxidation and the like, and also contains a natural antioxidant vitamin E, so that excessive free radicals generated due to pathological changes are eliminated, and the tea oil has good effects of reducing blood pressure, reducing blood fat and resisting oxidation.
Description
Technical Field
The invention relates to the technical field of medicinal preparations, in particular to a camellia oleifera polyphenol composition with a blood fat reducing function and a preparation method thereof.
Background
Cardiovascular diseases are common diseases, and according to related literature reports, more than 1.5 hundred million cardiovascular disease patients in China die of the cardiovascular diseases every year, and the number of the patients die is about 50% of the number of the patients who die of the cardiovascular diseases due to the diseases. Scientists have recently discovered that atherosclerosis is the leading culprit in cardiovascular and cerebrovascular diseases. The causes of atherosclerosis are very complicated, but hyperlipidemia is widely considered to be an important cause of atherosclerosis. Blood lipid is a general term for lipids contained in blood, and mainly includes cholesterol (TC), Triglyceride (TG), phospholipids, fatty acids, and the like. Hyperlipidemia, which is higher than the upper limit of normal individuals, is called hyperlipidemia, and is also called hyperlipoproteinemia because blood lipid is transported in the form of lipoprotein in the blood. The search for effective blood lipid-lowering drugs from each link of lipid metabolism (digestion, absorption, transformation, degradation and excretion) is an urgent task at present.
Disclosure of Invention
The invention aims to solve the technical problems and provide a camellia oleifera polyphenol composition with the function of reducing blood fat and a preparation method thereof.
In order to achieve the purpose of the invention, the invention adopts the technical scheme that:
a tea-oil tree polyphenol composition with a blood fat reducing function comprises the following raw materials in parts by weight:
36-48 parts of tea-seed oil, 2-5 parts of tea-oil polyphenol, 13-21 parts of natural vitamin E, 3-5 parts of hawthorn powder, 2-6 parts of pseudo-ginseng powder, 8-12 parts of a red sage root extract and 2-3 parts of mineral dry powder.
A preparation method of a tea-oil polyphenol composition with a blood fat reducing function comprises the following steps:
step 1, performing superfine processing on part of raw materials, respectively grinding hawthorn, pseudo-ginseng, salvia miltiorrhiza and mineral substances, and sieving to obtain hawthorn powder, pseudo-ginseng powder, salvia miltiorrhiza extract and mineral substance dry powder;
step 2, uniformly mixing the tea-seed oil, the tea-oil polyphenol and the natural vitamin E, and dividing into three equal parts, namely a mixed solution A, a mixed solution B and a mixed solution C;
step 3, weighing hawthorn powder, pseudo-ginseng powder, red sage root extract and dry mineral powder in parts by weight, adding the hawthorn powder, the pseudo-ginseng powder and the red sage root extract into the mixed solution A for mixing, placing the mixture in an ultrasonic container, carrying out ultrasonic treatment for 3.5-6.0h at the temperature of 60-70 ℃ and the frequency of 200-300Hz, and filtering to obtain mixed tea oil I;
adding the mineral dry powder into the mixed liquid B, and stirring to obtain a second mixed tea oil;
step 4, uniformly mixing the mixed tea oil I, the mixed tea oil II and the mixed liquid C to obtain primarily treated tea oil, heating to 70-80 ℃, and stirring for 20-30min under the condition of heat preservation;
step 5, filtering and washing the primarily treated tea oil, and taking supernatant;
and 6, filtering again through an ultrafiltration membrane device to obtain the camellia oleifera polyphenol composition.
Further, the preparation method comprises the step of preparing the camellia oleifera polyphenol composition into soft capsules.
Further, the camellia oleifera polyphenol is directly extracted by refluxing with ethanol, the method comprises the steps of extracting crushed camellia oleifera shells with ethanol with the volume concentration of 95%, controlling the weight ratio of the ethanol to the camellia oleifera shells to be 8-14L/kg, controlling the refluxing temperature to be 55-65 ℃, refluxing for 20-40 min each time, filtering, repeatedly extracting with ethanol for 3-5 times, combining filtrates, concentrating under reduced pressure to obtain alcohol-soluble polyphenol products, and recycling the ethanol.
Further, the size of the sieve holes screened in the step 1 is 50-80 meshes.
The invention has the beneficial effects that: the tea oil is taken as a main body, the content of monounsaturated fatty acid in the tea oil is high, and the tea oil also has the function of reducing blood fat; the tea oil is rich in tea polyphenol with remarkable antioxidation, the tea polyphenol in the tea oil has the functions of reducing blood fat, resisting oxidation and the like, and also contains a natural antioxidant vitamin E, so that excessive free radicals generated due to pathological changes are eliminated, and the tea oil has good effects of reducing blood pressure, reducing blood fat and resisting oxidation; the hawthorn, the pseudo-ginseng and the red sage root have the functions of reducing cholesterol and triglyceride, have good prevention and treatment effects on hyperlipemia and hypertension, and substances contained in the hawthorn can expand blood vessels, reduce blood pressure and reduce cholesterol; the adopted plant medicament has high safety and is suitable for various age groups; the mineral acts on related factors in vivo, effectively prevents damage to the inner wall of the blood vessel, prevents arteriosclerosis and the like; the capsule is prepared from the raw materials, and is convenient to carry.
Detailed Description
In order to make the content of the present invention more clearly understood, the technical solutions in the embodiments of the present invention are clearly and completely described below.
Example one
A tea-oil tree polyphenol composition with a blood fat reducing function comprises the following raw materials in parts by weight:
36 parts of tea-seed oil, 2 parts of tea-oil polyphenol, 13 parts of natural vitamin E, 3 parts of hawthorn powder, 2 parts of pseudo-ginseng powder, 8 parts of a red-rooted salvia root extract and 2 parts of mineral dry powder.
Example two
A tea-oil tree polyphenol composition with a blood fat reducing function comprises the following raw materials in parts by weight:
48 parts of tea-seed oil, 5 parts of tea-oil polyphenol, 21 parts of natural vitamin E, 5 parts of hawthorn powder, 6 parts of pseudo-ginseng powder, 12 parts of salvia miltiorrhiza extract and 3 parts of mineral dry powder.
EXAMPLE III
A tea-oil tree polyphenol composition with a blood fat reducing function comprises the following raw materials in parts by weight:
42 parts of tea-seed oil, 4 parts of tea-oil polyphenol, 15 parts of natural vitamin E, 4 parts of hawthorn powder, 4 parts of pseudo-ginseng powder, 10 parts of a red-rooted salvia root extract and 2.5 parts of mineral dry powder.
A preparation method of a tea-oil polyphenol composition with a blood fat reducing function comprises the following steps:
step 1, performing superfine processing on part of raw materials, respectively grinding hawthorn, pseudo-ginseng, salvia miltiorrhiza and mineral substances into powder, and sieving to obtain hawthorn powder, pseudo-ginseng powder, salvia miltiorrhiza extract and mineral substance dry powder, wherein the size of a sieve mesh is 70 meshes;
step 2, uniformly mixing the tea-seed oil, the tea-oil polyphenol and the natural vitamin E, and dividing into three equal parts, namely a mixed solution A, a mixed solution B and a mixed solution C; the method comprises the steps of extracting crushed oil tea shells with ethanol with volume concentration of 95%, controlling the reflux temperature to be 60 ℃ and the reflux time to be 30min each time, filtering, repeating alcohol extraction for 3 times, combining filtrate, and carrying out reduced pressure concentration to obtain alcohol-soluble polyphenol products, wherein the ethanol is recycled;
step 3, weighing hawthorn powder, pseudo-ginseng powder, red sage root extract and dry mineral powder in parts by weight, adding the hawthorn powder, the pseudo-ginseng powder and the red sage root extract into the mixed liquid A for mixing, placing the mixture into an ultrasonic container, carrying out ultrasonic treatment for 3.5 hours at the temperature of 60 ℃ and the frequency of 200Hz, and filtering to obtain mixed tea oil I;
adding the mineral dry powder into the mixed liquid B, and stirring to obtain a second mixed tea oil;
step 4, uniformly mixing the mixed tea oil I, the mixed tea oil II and the mixed liquid C to obtain primarily treated tea oil, heating to 70 ℃, and keeping the temperature and stirring for 20 min;
step 5, filtering and washing the primarily treated tea oil, and taking supernatant;
and 6, filtering again through an ultrafiltration membrane device to obtain the camellia oleifera polyphenol composition.
And 7, preparing the camellia oleifera polyphenol composition into soft capsules.
The tea oil is taken as a main body, the content of monounsaturated fatty acid in the tea oil is high, and the tea oil also has the function of reducing blood fat; the tea oil is rich in tea polyphenol with remarkable antioxidation, the tea polyphenol in the tea oil has the functions of reducing blood fat, resisting oxidation and the like, and also contains a natural antioxidant vitamin E, so that excessive free radicals generated due to pathological changes are eliminated, and the tea oil has good effects of reducing blood pressure, reducing blood fat and resisting oxidation; the hawthorn, the pseudo-ginseng and the red sage root have the functions of reducing cholesterol and triglyceride, have good prevention and treatment effects on hyperlipemia and hypertension, and substances contained in the hawthorn can expand blood vessels, reduce blood pressure and reduce cholesterol; the adopted plant medicament has high safety and is suitable for various age groups; the mineral acts on related factors in vivo, effectively prevents damage to the inner wall of the blood vessel, prevents arteriosclerosis and the like; the capsule is prepared from the raw materials, and is convenient to carry.
The effect achieved by the formula is generated by matching various substances together, and can not be divided out to demonstrate one by one.
The present invention and the embodiments thereof have been described above, but the description is not limited to the embodiments, but only one of the embodiments of the present invention, and the actual embodiments are not limited thereto. In conclusion, those skilled in the art should appreciate that they can readily use the disclosed conception and specific embodiments as a basis for designing or modifying other structures for carrying out the same purposes of the present invention without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (5)
1. A tea-oil tree polyphenol composition with a blood fat reducing function is characterized by comprising the following raw materials in parts by weight:
36-48 parts of tea-seed oil, 2-5 parts of tea-oil polyphenol, 13-21 parts of natural vitamin E, 3-5 parts of hawthorn powder, 2-6 parts of pseudo-ginseng powder, 8-12 parts of a red sage root extract and 2-3 parts of mineral dry powder.
2. A preparation method of a tea-oil polyphenol composition with a blood fat reducing function is characterized by comprising the following steps:
step 1, performing superfine processing on part of raw materials, respectively grinding hawthorn, pseudo-ginseng, salvia miltiorrhiza and mineral substances, and sieving to obtain hawthorn powder, pseudo-ginseng powder, salvia miltiorrhiza extract and mineral substance dry powder;
step 2, uniformly mixing the tea-seed oil, the tea-oil polyphenol and the natural vitamin E, and dividing into three equal parts, namely a mixed solution A, a mixed solution B and a mixed solution C;
step 3, weighing hawthorn powder, pseudo-ginseng powder, red sage root extract and dry mineral powder in parts by weight, adding the hawthorn powder, the pseudo-ginseng powder and the red sage root extract into the mixed solution A for mixing, placing the mixture in an ultrasonic container, carrying out ultrasonic treatment for 3.5-6.0h at the temperature of 60-70 ℃ and the frequency of 200-300Hz, and filtering to obtain mixed tea oil I;
adding the mineral dry powder into the mixed liquid B, and stirring to obtain a second mixed tea oil;
step 4, uniformly mixing the mixed tea oil I, the mixed tea oil II and the mixed liquid C to obtain primarily treated tea oil, heating to 70-80 ℃, and stirring for 20-30min under the condition of heat preservation;
step 5, filtering and washing the primarily treated tea oil, and taking supernatant;
and 6, filtering again through an ultrafiltration membrane device to obtain the camellia oleifera polyphenol composition.
3. The preparation method of the camellia oleifera polyphenol composition with the function of reducing blood fat according to claim 2, wherein the preparation method comprises the following steps: also comprises preparing the tea-oil polyphenol composition into soft capsules.
4. The preparation method of the camellia oleifera polyphenol composition with the function of reducing blood fat according to claim 2, wherein the preparation method comprises the following steps: the method comprises the steps of extracting crushed oil tea shells with ethanol with the volume concentration of 95%, controlling the weight ratio of the ethanol to the oil tea shells to be 8-14L/kg, controlling the reflux temperature to be 55-65 ℃, refluxing for 20-40 min each time, filtering, repeatedly extracting with ethanol for 3-5 times, combining filtrates, concentrating under reduced pressure to obtain alcohol-soluble polyphenol products, and recycling the ethanol.
5. The preparation method of the camellia oleifera polyphenol composition with the function of reducing blood fat according to claim 2, wherein the preparation method comprises the following steps: the size of the sieve holes sieved in the step 1 is 50-80 meshes.
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| CN114098071A (en) * | 2021-10-12 | 2022-03-01 | 怀化市富源油业有限公司 | Camellia seed oil oral liquid for resisting hypertension, hyperglycemia and hyperlipidemia and preparation process thereof |
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Application publication date: 20210611 |