CN108378367A - A kind of plant extract composition of auxiliary hyperglycemic and preparation method thereof and solid beverage - Google Patents
A kind of plant extract composition of auxiliary hyperglycemic and preparation method thereof and solid beverage Download PDFInfo
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- CN108378367A CN108378367A CN201810201657.2A CN201810201657A CN108378367A CN 108378367 A CN108378367 A CN 108378367A CN 201810201657 A CN201810201657 A CN 201810201657A CN 108378367 A CN108378367 A CN 108378367A
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- 239000000203 mixture Substances 0.000 title claims abstract description 42
- 239000000419 plant extract Substances 0.000 title claims abstract description 33
- 239000007787 solid Substances 0.000 title claims abstract description 21
- 230000003345 hyperglycaemic effect Effects 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 235000013361 beverage Nutrition 0.000 title claims abstract description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 75
- 238000001035 drying Methods 0.000 claims abstract description 22
- 241000234282 Allium Species 0.000 claims abstract description 16
- 235000002732 Allium cepa var. cepa Nutrition 0.000 claims abstract description 16
- 240000002234 Allium sativum Species 0.000 claims abstract description 16
- 241000233866 Fungi Species 0.000 claims abstract description 16
- 244000013123 dwarf bean Species 0.000 claims abstract description 16
- 235000004611 garlic Nutrition 0.000 claims abstract description 16
- 235000021278 navy bean Nutrition 0.000 claims abstract description 16
- 235000002722 Dioscorea batatas Nutrition 0.000 claims abstract description 15
- 235000006536 Dioscorea esculenta Nutrition 0.000 claims abstract description 15
- 240000001811 Dioscorea oppositifolia Species 0.000 claims abstract description 15
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 claims abstract description 15
- 244000302512 Momordica charantia Species 0.000 claims abstract description 14
- 235000009811 Momordica charantia Nutrition 0.000 claims abstract description 14
- 238000000108 ultra-filtration Methods 0.000 claims abstract description 14
- 238000001694 spray drying Methods 0.000 claims abstract description 11
- 235000009812 Momordica cochinchinensis Nutrition 0.000 claims abstract description 10
- 235000018365 Momordica dioica Nutrition 0.000 claims abstract description 10
- 239000000469 ethanolic extract Substances 0.000 claims abstract description 4
- 239000003513 alkali Substances 0.000 claims description 36
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 34
- 239000000284 extract Substances 0.000 claims description 31
- 241000196324 Embryophyta Species 0.000 claims description 17
- 239000000463 material Substances 0.000 claims description 16
- 239000000706 filtrate Substances 0.000 claims description 15
- 238000002156 mixing Methods 0.000 claims description 14
- 239000000843 powder Substances 0.000 claims description 12
- 239000002253 acid Substances 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 9
- 239000012528 membrane Substances 0.000 claims description 7
- 229920002472 Starch Polymers 0.000 claims description 6
- 239000008107 starch Substances 0.000 claims description 6
- 229920001353 Dextrin Polymers 0.000 claims description 5
- 239000004375 Dextrin Substances 0.000 claims description 5
- 229920002774 Maltodextrin Polymers 0.000 claims description 5
- 239000005913 Maltodextrin Substances 0.000 claims description 5
- 235000019425 dextrin Nutrition 0.000 claims description 5
- 238000000605 extraction Methods 0.000 claims description 5
- 229940035034 maltodextrin Drugs 0.000 claims description 5
- 235000019698 starch Nutrition 0.000 claims description 5
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 4
- 229920000858 Cyclodextrin Polymers 0.000 claims description 4
- 239000001116 FEMA 4028 Substances 0.000 claims description 4
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 4
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 4
- 229960004853 betadex Drugs 0.000 claims description 4
- 235000010445 lecithin Nutrition 0.000 claims description 4
- 239000000787 lecithin Substances 0.000 claims description 4
- 229940067606 lecithin Drugs 0.000 claims description 4
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 5
- 230000002218 hypoglycaemic effect Effects 0.000 abstract description 5
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- 241000700159 Rattus Species 0.000 description 7
- 239000003814 drug Substances 0.000 description 7
- 239000008103 glucose Substances 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical class [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000000047 product Substances 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 206010012601 diabetes mellitus Diseases 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 235000011121 sodium hydroxide Nutrition 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 238000004061 bleaching Methods 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 201000001421 hyperglycemia Diseases 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 244000241257 Cucumis melo Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- CYTYCFOTNPOANT-UHFFFAOYSA-N Perchloroethylene Chemical group ClC(Cl)=C(Cl)Cl CYTYCFOTNPOANT-UHFFFAOYSA-N 0.000 description 1
- JLRGJRBPOGGCBT-UHFFFAOYSA-N Tolbutamide Chemical compound CCCCNC(=O)NS(=O)(=O)C1=CC=C(C)C=C1 JLRGJRBPOGGCBT-UHFFFAOYSA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 238000003916 acid precipitation Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 229940069765 bean extract Drugs 0.000 description 1
- 229930185803 charantin Natural products 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 235000004879 dioscorea Nutrition 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 235000021388 linseed oil Nutrition 0.000 description 1
- 239000000944 linseed oil Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229950011008 tetrachloroethylene Drugs 0.000 description 1
- 229960005371 tolbutamide Drugs 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The present invention relates to plant extract composition of a kind of auxiliary hyperglycemic and preparation method thereof and solid beverages, belong to hypoglycemic technical field.Composition provided by the invention includes：3.2~3.9 parts of ethanol extracts from Momordica charantia, 4.5~5.1 parts of Chinese lute alcohol extracting thing, 3.4~4.5 parts of Chinese yam alcohol extracting thing, 1.2~1.7 parts of navy bean alcohol extracting thing, 1.9~2.4 parts of 2.3~3.1 parts of onion alcohol extracting thing, 1.9~2.6 parts of garlic alcohol extracting thing and black fungus alcohol extracting thing；The alcohol extracting thing is obtained by balsam pear, Chinese lute, Chinese yam, navy bean, onion, garlic and black fungus difference drying, crushing, alcohol extracting, ultrafiltration, purifying and spray drying；The condition of the spray drying includes：200 DEG C of inlet air temperature, pan feeding flow 60mL/min, rotating speed of shower nozzle 25000r/min.Plant extract composition provided by the invention can be hypoglycemic, and has no toxic side effect.
Description
Technical field
The present invention relates to hypoglycemic technical fields, and in particular to a kind of the plant extract composition and its system of auxiliary hyperglycemic
Preparation Method and solid beverage.
Background technology
Auxiliary hyperglycemic product is generally drug and health products at present, and drug is chemical synthesis or microorganism using raw material
Tunning, health products compare mostly Chinese medicine using raw material.Although drug and health products in the market is dropped with auxiliary treatment
The effect of blood glucose, but there are certain toxic side effects for these drugs or health products.
Invention content
The purpose of the present invention is to provide plant extract composition of a kind of auxiliary hyperglycemic and preparation method thereof and solids
Beverage.Plant extract composition provided by the invention can be hypoglycemic, and has no toxic side effect.
The present invention provides a kind of plant extract compositions of auxiliary hyperglycemic, include the component of following parts by weight：Balsam pear
3.2~3.9 parts of alcohol extracting thing, 4.5~5.1 parts of Chinese lute alcohol extracting thing, 3.4~4.5 parts of Chinese yam alcohol extracting thing, navy bean alcohol extracting
1.2~1.7 parts of object, 2.3~3.1 parts of onion alcohol extracting thing, 1.9~2.6 parts of garlic alcohol extracting thing and black fungus alcohol extracting thing 1.9
~2.4 parts；
Each alcohol extracting thing is respectively by balsam pear, Chinese lute, Chinese yam, navy bean, onion, garlic and black fungus successively drying, powder
Broken, alcohol extracting, ultrafiltration, purifying and spray drying obtain；
The condition of the spray drying includes：200 DEG C of inlet air temperature, pan feeding flow 60mL/min, rotating speed of shower nozzle 25000r/
min。
The present invention also provides the preparation methods of composition described in above-mentioned technical proposal, include the following steps：
1) it is crushed after respectively drying plant material, crosses 80 mesh and sieve to obtain plant powder；
2) it is according to solid-liquid ratio by the ethanol water that the plant powder that step 1) obtains is respectively 75% with mass fraction
1:6g/mL mixing carries out alcohol extracting, obtains alcohol extract；
3) by alcohol extract that the step 2) obtains respectively membrane aperture is 100nm, feed temperature is 35 DEG C and ultrafiltration pressure
Power is ultrafiltration under the conditions of 0.18MPa, obtains filtrate；
4) filtrate that the step 3) obtains is purified respectively, obtains purified, the purifying includes by the filter
It is heavy that liquid carries out alkali carries, hydrogen peroxide for decoloration and acid successively；
The alkali carries are：By the filtrate under the conditions of pH value is 10, alkali carries temperature is 50 DEG C alkali carries 50min, obtain alkali
Extract；
The hydrogen peroxide for decoloration is：The hydrogen peroxide that mass fraction is 30% is mixed with alkali extract, 45 DEG C of decoloration 60min,
Obtain destainer；
The acid, which sinks, is：The pH value of the destainer is adjusted to 5；
5) purified that the step 4) obtains is spray-dried respectively, each plant extracts is obtained, by what is obtained
Each plant extracts mixing, obtains the plant extract composition of auxiliary hyperglycemic.
Preferably, the temperature of the step 1) drying is 60 DEG C.
Preferably, the temperature of the step 2) alcohol extracting is 50 DEG C；The number of alcohol extracting is 3 times；The time of alcohol extracting is every time
60min。
Preferably, the number of the step 4) alkali carries is 3 times.
Preferably, the step 4) hydrogen peroxide is 1 according to volume ratio with alkali extract：12 mixing.
Preferably, drying aid is also added during the step 5) spray drying.
Preferably, the drying aid is on the basis of the quality of purified described in step 5), including following quality percentage contains
The component of amount：2.5% lecithin, 2.5% beta-cyclodextrin and 3.0% soluble starch.
The present invention also provides preparation methods described in the composition based on the above-mentioned technical proposal or above-mentioned technical proposal to obtain
The solid beverage of the composition arrived, the solid beverage contain plant extract composition and auxiliary material；Extraction composition accounts for solid drink
Expect the 80~85% of weight.
Preferably, the auxiliary material includes maltodextrin and resistant dextrin.
The present invention provides a kind of plant extract compositions of auxiliary hyperglycemic.The plant extract composition of the present invention is with hardship
Melon, Chinese lute, Chinese yam, navy bean, onion, garlic and black fungus are raw material, and alcohol extracting obtains, and each group is divided into natural plants.Experiment knot
Fruit shows that plant extract composition provided by the invention can reduce diabetes rat fasting blood-glucose, the difference with model control group
With conspicuousness.
Specific implementation mode
The present invention provides a kind of plant extract compositions of auxiliary hyperglycemic, include the component of following parts by weight：Balsam pear
3.2~3.9 parts of alcohol extracting thing, 4.5~5.1 parts of Chinese lute alcohol extracting thing, 3.4~4.5 parts of Chinese yam alcohol extracting thing, navy bean alcohol extracting
1.2~1.7 parts of object, 2.3~3.1 parts of onion alcohol extracting thing, 1.9~2.6 parts of garlic alcohol extracting thing and black fungus alcohol extracting thing 1.9
~2.4 parts；
Each alcohol extracting thing is respectively by balsam pear, Chinese lute, Chinese yam, navy bean, onion, garlic and black fungus successively drying, powder
Broken, alcohol extracting, ultrafiltration, purifying and spray drying obtain.In the present invention, the ethanol extracts from Momordica charantia is preferably 3.5 parts, the plucked string instrument with a fretted fingerboard
Pa alcohol extracting things are preferably 5.0 parts, and the Chinese yam alcohol extracting thing is preferably 3.8 parts, and the navy bean alcohol extracting thing is preferably 1.5
Part, the onion alcohol extracting thing is preferably 2.6 parts, and the garlic alcohol extracting thing is preferably 2.2 parts and the black fungus alcohol extracting
Object is preferably 2.2 parts.
In the present invention, the standby raw material processed of the composition includes the component of following parts by weight：Balsam pear 1000~1200
Part, 950~1100 parts of Chinese lute, 930~1200 parts of Chinese yam, 890~950 parts of navy bean, 750~840 parts of onion, garlic 745~
810 parts and 730~820 parts of black fungus.The present invention is to the balsam pear, Chinese lute, Chinese yam, navy bean, onion, garlic and black fungus
Source does not have special restriction, using balsam pear well known to those skilled in the art, Chinese lute, Chinese yam, navy bean, onion, garlic and
The conventional commercial product of black fungus.In the present invention, Bitter Melon P.E contains high-purity Charantin, has similar insulin
Effect, can auxiliary hyperglycemic；Contain high-purity crude fibre and vitamin C in Chinese lute, yam extract；In navy bean extract
Inhibit enzyme containing high-purity beta-starch, conversion of the starch to glucose can be effectively blocked, to reduce blood glucose；Onion, garlic carry
It takes and contains hypoglycemic medicine tolbutamide in object；Polysaccharide containing higher purity in black fungus extract；Pass through these natural plants
It can extract out these active principles and auxiliary hyperglycemic effect reached by compounding supplement a variety of active ingredients.
The present invention also provides the preparation methods of composition described in above-mentioned technical proposal, include the following steps：
1) it is crushed after respectively drying plant material, crosses 80 mesh and sieve to obtain plant powder；
2) it is 1 according to solid-liquid ratio by ethanol solution that the plant powder that step 1) obtains is respectively 75% with mass fraction:
6g/mL is mixed, and alcohol extracting obtains alcohol extract 3 times；
3) by alcohol extract that the step 2) obtains respectively membrane aperture is 100nm, feed temperature is 35 DEG C and ultrafiltration pressure
Power is ultrafiltration under the conditions of 0.18MPa, obtains filtrate；
4) filtrate that the step 3) obtains is purified respectively, obtains purified, the purifying includes by the filter
It is heavy that liquid carries out alkali carries, hydrogen peroxide for decoloration and acid successively；
The alkali carries are：By the filtrate under the conditions of pH value is 10, alkali carries temperature is 50 DEG C alkali carries 50min, obtain alkali
Extract；
The hydrogen peroxide for decoloration is：The hydrogen peroxide that mass fraction is 30% is mixed with alkali extract, 45 DEG C of decoloration 60min,
Obtain destainer；
The acid, which sinks, is：The pH value of the destainer is adjusted to 5；
5) purified that the step 4) obtains is spray-dried respectively, each plant extracts is obtained, by what is obtained
Each plant extracts mixing, obtains the plant extract composition of auxiliary hyperglycemic.
The present invention crushes after respectively drying plant material, crosses 80 mesh and sieves to obtain plant powder.In the present invention, the baking
Dry temperature is preferably 60 DEG C.In the present invention, the time of the drying is preferably 30min.
After obtaining plant powder, the present invention by plant powder respectively with mass fraction be 75% ethanol water according to material
Liquor ratio is 1:6g/mL mixing carries out alcohol extracting, obtains alcohol extract.In the present invention, the temperature of the alcohol extracting is preferably 50 DEG C；Every time
The time of alcohol extracting is preferably 60min.In the present invention, the number of the alcohol extracting is preferably 3 times, and obtained alcohol extract merges to obtain
Alcohol extract.In the present invention, the mode of the alcohol extracting is preferably derect seething.
After obtaining alcohol extract, the present invention is by the alcohol extract respectively membrane aperture is 100nm, feed temperature is 35 DEG C and super
Filtering pressure power is ultrafiltration under the conditions of 0.18MPa, obtains filtrate.In the present invention, the filter membrane that the ultrafiltration uses is preferably poly- tetrachloro
Ethylene filter membrane.
After obtaining filtrate, the present invention purifies the filtrate respectively, obtains purified, the purifying includes will be described
It is heavy that filtrate carries out alkali carries, hydrogen peroxide for decoloration and acid successively；The alkali carries are：By the filtrate pH value is 10, alkali carries temperature is
Alkali carries 50min, obtains alkali extract under the conditions of 50 DEG C；In the present invention, it is preferable to use sodium hydroxides to carry out pH value for the alkali carries
It adjusts, in the present invention, the concentration of the sodium hydroxide is preferably 1.2mol/L.In the present invention, the number of the alkali carries is excellent
It is selected as 3 times, 3 times obtained lye merges to obtain alkali extract.
The hydrogen peroxide for decoloration is：The hydrogen peroxide that mass fraction is 30% is mixed with alkali extract, 45 DEG C of decoloration 60min,
Obtain destainer；In the present invention, the hydrogen peroxide is 1 according to volume ratio with alkali extract：12 mixing；
The acid, which sinks, is：The pH value of the destainer is adjusted to 5.The method that the present invention adjusts the pH value is not special
Restriction, be adjusted using acid regulator well known to those skilled in the art.
After obtaining purified, purified is spray-dried by the present invention respectively, obtains each plant extracts, by what is obtained
Each plant extracts mixing, obtains the plant extract composition of auxiliary hyperglycemic.In the present invention, the condition of the spray drying
For：200 DEG C of inlet air temperature, pan feeding flow 60mL/min, rotating speed of shower nozzle 25000r/min.In the present invention, the spray drying
During also add drying aid.In the present invention, the drying aid is on the basis of the quality of the purified, including following matter
Measure the component of percentage composition：2.5% lecithin, 2.5% beta-cyclodextrin and 3.0% soluble starch.
After obtaining the extract of each plant, the present invention does not have the hybrid mode of the extract special limitation, uses
Extract hybrid mode well known to those skilled in the art.Present invention preferably employs equal increments method mixing, i.e., mix two-by-two
Incremental manner step by step is closed, is finished and specifically, it is preferable to swing 10min mixing in three-dimensional motion mixer intermediate cam.The present invention is to institute
The dosage form for stating plant extract composition does not have special restriction, preferably solid beverage dosage form.
The present invention also provides preparation methods described in the composition based on the above-mentioned technical proposal or above-mentioned technical proposal to obtain
The solid beverage of the composition arrived, the solid beverage contain plant extract composition and auxiliary material；Extraction composition accounts for solid drink
The 80~85% of material weight, more preferably 82%.
In the present invention, the auxiliary material includes maltodextrin and resistant dextrin.In the present invention, the system of the solid beverage
It is standby that plant extract composition is preferably first put into 80 DEG C of baking ovens to dry, reduction moisture；Then by the composition after drying
It is mixed with auxiliary material.In the present invention, the additive amount of the auxiliary material is preferably 5% of composition quality after drying.In the present invention,
The mixing quality of the maltodextrin and resistant dextrin ratio is preferably 1：(2~2.8).In the present invention, the solid beverage punching
Water can be taken, and blood sugar decreasing effect is good.
With reference to specific embodiment to a kind of the plant extract composition and its system of auxiliary hyperglycemic of the present invention
Preparation Method and solid beverage are further described in detail, and technical scheme of the present invention includes but not limited to following embodiment.
Embodiment 1
Balsam pear 1200g, Chinese lute 950g, Chinese yam 930g, navy bean 890g, onion 750g, garlic 745g, black fungus are taken respectively
730g；
It is crushed after 60 DEG C of drying in oven, obtained the powder of the quasi- medicine sieve of 80 targets；
In 3 concentration of alcohol 75%, solid-liquid ratio 1: 6,50 DEG C of Extracting temperature, extraction each 60min；
It is 100nm in membrane aperture, feed temperature is 35 DEG C, and ultrafiltration pressure is ultrafiltration under the conditions of 0.18MPa；
Then polishing purification, technological parameter are carried out to filtered extract with alkali extraction and acid precipitation and hydrogen peroxide for decoloration method
For：PH=10, solid-liquid ratio 1: 12, alkali carries temperature 50 C, 3 each 50min of alkali carries, 30% hydrogen peroxide and alkali carries liquid proportional 1:
20,45 DEG C of bleaching temperature, bleaching time 60min, the heavy pH=5 of acid；
Drying process with atomizing parameter：200 DEG C of inlet air temperature, pan feeding flow 60mL/min, rotating speed of shower nozzle 25000r/min；Material
The lecithin, 2.5% beta-cyclodextrin, 3.0% solubility that drying aid dispensing is (accounting for solid content) 2.5% are added in liquid
Starch obtains ethanol extracts from Momordica charantia 3.2g, Chinese lute alcohol extracting thing 4.5g, Chinese yam alcohol extracting thing 3.4g, navy bean alcohol extracting thing
1.2g, onion alcohol extracting thing 2.3g, garlic alcohol extracting thing 1.9g, black fungus alcohol extracting thing 1.9g.
Each plant extracts is mixed using equal increments method, i.e., mixes incremental manner step by step two-by-two, is mixed in three-dimensional motion
Machine intermediate cam swings 10min mixing and finishes；
It is put into after mixing in 80 DEG C of baking ovens dry；
5% maltodextrin and resistant dextrin are mixed into major ingredient, solid beverage is made in filling, and bath can take.
Embodiment 2
High sugar feed feeds SD male rats and establishes hyperglycemia model；Hyperglycemia model rat disposable celiac is injected
40mg/kg streptozotocins establish diabetes model；Experiment is divided into model control group, and the plant extract composition of auxiliary hyperglycemic is matched
Side low (10g/d), in (20g/d), high (30g/d) dosage group (n=8), continuous gavage is after 30 days, measure rat fasting blood-glucose and
Sugar tolerance.
GSH contents are above control group, wherein middle dose group and control group GSH content differences in each dosage group rat blood serum
With statistical significance (P<0.05)；The plant extract composite formula group of high dose auxiliary hyperglycemic can reduce diabetes rat
Fasting blood-glucose has conspicuousness (P with the difference of model control group<0.05)；There is linseed oil auxiliary to reduce diabetes rat
The function of blood glucose.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of plant extract composition of auxiliary hyperglycemic, includes the component of following parts by weight：Ethanol extracts from Momordica charantia 3.2~
3.9 parts, 4.5~5.1 parts of Chinese lute alcohol extracting thing, 3.4~4.5 parts of Chinese yam alcohol extracting thing, 1.2~1.7 parts of navy bean alcohol extracting thing,
1.9~2.4 parts of 2.3~3.1 parts of onion alcohol extracting thing, 1.9~2.6 parts of garlic alcohol extracting thing and black fungus alcohol extracting thing；
Each alcohol extracting thing is respectively by balsam pear, Chinese lute, Chinese yam, navy bean, onion, garlic and black fungus successively drying, crushing, alcohol
Carry, ultrafiltration, purifying and spray drying obtain；
The condition of the spray drying includes：200 DEG C of inlet air temperature, pan feeding flow 60mL/min, rotating speed of shower nozzle 25000r/min.
2. the preparation method of composition described in claim 1, includes the following steps：
1) it is crushed after respectively drying plant material, crosses 80 mesh and sieve to obtain plant powder；
2) it is 1 according to solid-liquid ratio by ethanol water that the plant powder that step 1) obtains is respectively 75% with mass fraction:6g/
ML mixing carries out alcohol extracting, obtains alcohol extract；
3) by alcohol extract that the step 2) obtains respectively membrane aperture is 100nm, feed temperature is 35 DEG C and ultrafiltration pressure is
Ultrafiltration under the conditions of 0.18MPa, obtains filtrate；
4) filtrate that the step 3) obtains is purified respectively, obtains purified, the purifying include by the filtrate according to
Secondary progress alkali carries, hydrogen peroxide for decoloration and acid are heavy；
The alkali carries are：By the filtrate under the conditions of pH value is 10, alkali carries temperature is 50 DEG C alkali carries 50min, obtain alkali extract；
The hydrogen peroxide for decoloration is：The hydrogen peroxide that mass fraction is 30% is mixed with alkali extract, 45 DEG C of decoloration 60min are obtained
Destainer；
The acid, which sinks, is：The pH value of the destainer is adjusted to 5；
5) purified that the step 4) obtains is spray-dried respectively, obtains each plant extracts, each plant that will be obtained
Object extract mixes, and obtains the plant extract composition of auxiliary hyperglycemic.
3. preparation method according to claim 2, which is characterized in that the temperature of the step 1) drying is 60 DEG C.
4. preparation method according to claim 2, which is characterized in that the temperature of the step 2) alcohol extracting is 50 DEG C；Alcohol extracting
Number be 3 times；The time of each alcohol extracting is 60min.
5. preparation method according to claim 2, which is characterized in that the number of the step 4) alkali carries is 3 times.
6. preparation method according to claim 2, which is characterized in that the step 4) hydrogen peroxide is with alkali extract according to volume
Than being 1：12 mixing.
7. preparation method according to claim 2, which is characterized in that also added during the step 5) spray drying
Drying aid.
8. preparation method according to claim 8, which is characterized in that the drying aid is with the matter of purified described in step 5)
On the basis of amount, include the component of following mass percentage：2.5% lecithin, 2.5% beta-cyclodextrin and 3.0% can
Soluble starch.
9. the solid drink based on the composition that composition described in claim 1 or claim 2~8 preparation method obtain
Material, which is characterized in that the solid beverage contains plant extract composition and auxiliary material；Extraction composition accounts for solid beverage weight
80~85%.
10. solid beverage according to claim 9, which is characterized in that the auxiliary material includes maltodextrin and resistant dextrin.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109567201A (en) * | 2019-01-04 | 2019-04-05 | 无锡海尔偲生命科技有限公司 | For blocking composition and the application of human body parts fat and carbohydrate absorption |
| CN115251259A (en) * | 2022-08-10 | 2022-11-01 | 河北华朗生物科技有限公司 | Bitter gourd compound beverage with blood sugar reducing effect and production process thereof |
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| CN106562315A (en) * | 2016-11-13 | 2017-04-19 | 南宁市浩发科技有限公司 | Diet food for reducing blood sugar |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109567201A (en) * | 2019-01-04 | 2019-04-05 | 无锡海尔偲生命科技有限公司 | For blocking composition and the application of human body parts fat and carbohydrate absorption |
| CN115251259A (en) * | 2022-08-10 | 2022-11-01 | 河北华朗生物科技有限公司 | Bitter gourd compound beverage with blood sugar reducing effect and production process thereof |
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