CN107496533A - A kind of composition containing loquat flower and application - Google Patents
A kind of composition containing loquat flower and application Download PDFInfo
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- CN107496533A CN107496533A CN201710908428.XA CN201710908428A CN107496533A CN 107496533 A CN107496533 A CN 107496533A CN 201710908428 A CN201710908428 A CN 201710908428A CN 107496533 A CN107496533 A CN 107496533A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention discloses a kind of composition containing loquat flower and application, it is made up of each component of following parts by weight：25~35 parts of loquat flower, 8~15 parts of Herba Andrographitis, 5~12 parts of Rabdosia rubescens, 5~10 parts of honeysuckle.Present invention also offers said composition to prepare the purposes in treating pharyngitis medicine, clear and definite especially for chronic pharyngitis, drug effect；The treatment pharyngitis medicine prepared using the present composition, drug effect is substantially better than existing preparation, and controllability is strong, and a kind of new selection is provided for clinic, and production cost is low, and preparation method is simple, is easy to industrialized production；A variety of formulations can be made as needed, convenient to take, the property of medicine is gentle, and raw material is natural food materials, is had no toxic side effect.
Description
Technical field
The invention belongs to drug field, more particularly, to a kind of composition containing loquat flower and application.
Background technology
Loquat flower system the rose family Eriobotrya loquat Eriobotrya japonica (Thunb) Lindl flower, distribution
In provinces and regions such as China Zhejiang, Jiangsu, Sichuan, Guangxi.Its is lightly seasoned according to records, warm-natured, enters lung channel.Researching and analysing in recent years shows
Loquat flower is nutritious, especially containing higher nutrient calcium, iron, zinc etc..In addition, loquat flower is rich in protein, 18 kinds
Amino acid, especially needed by human 8 kinds of amino acid, fat, vitamin, crude fibre, carbohydrate, mineral constituents contents are equal
It is higher, there is higher nutritive value.Loquat flower contains the medicinal ingredients such as triterpenoid saponin, have resolving sputum, cough-relieving, preventing and treating headache,
Cold and other effects, triterpene compound has multiple biological activities, in recent years it has also been found that some compounds have AntiHIV1 RT activity and resisted swollen
Tumor activity, thus paid attention to by researcher, in addition, loquat flower still makes the good raw material of natural health-care beverage.
Chronic pharyngitis is the chronic inflammation of pharyngeal mucous membrane, submucosa and lymphoid tissue, depending on its lesion situation, can be divided into list
Pure property, Hypertrophic and atrophic three types.The pathogenic factor of chronic pharyngitis is a lot, such as acpuei pharyngitis recurrent exerbation and neighbouring device
Official's disease (chronic tonsillitis, gingivitis, rhinitis chronic, chronic nasosinusitis) etc. can all cause.External cause very cold is dried, work
The air made in environment is polluted by dust, chemical gas, tobacco and wine and pungent diet long-time stimulus, and is used due to occupational factor
The excessive people of throat is susceptible to suffer from chronic pharyngitis.In addition, it is irregular, tired, nervous to live for a long time, can make under passive protective physical fitness
Drop, bacterium and the easy repeated infection of virus, can also cause chronic pharyngitis.The pharyngeal sense of discomfort of chronic pharyngitis or foreign body sensation, dry, scabies
Gargalesthesia, burning heat sensation, hypodynia sense is pharyngeal to have phlegm etc., but without prejudice to feed；Foreign matter sense of obstruction is obvious when saliva is swallowed, but enters dry
Property food when then unobvious, the above is felt often cause very brief and frequently cough, more acute from morning, and easily causes nausea；
With during the air that throat is excessive, abrupt change of climate or suction are dry and cold and after tobacco and wine, above-mentioned symptom can aggravate, and check visible pharyngeal mucosa
Chronic congestion, the drying of pharynx rear wall or lymph foilicie hyperplasia.To sum up, the cardinal symptom of chronic pharyngitis be it is pharyngeal have a foreign body sensation, it is pharyngeal
Dry, cough etc. is not cardinal symptom.
The normal recurrent exerbation of the state of an illness of chronic pharyngitis, does not recover for a long time, is acquired a certain degree of difficulty in treatment, in addition to microorganism infection, changes
Pharyngeal inflammation can also be caused by learning the stimulation of material.In addition, chronic pharyngeal a big chunk be not due to it is bacterial, but
Caused by some long-term physical chemistry stimulate.The method for the treatment of chronic pharyngitis is many at present, advocates as doctor trained in Western medicine
With the gargles such as mouth Thailand, Dobell's solution, buccal Dobell, Anji lozenge etc..These medicine long-term uses can cause oral cavity
Interior environment disturbance.For plump hyperplastic pharyngitis, the methods of laser, microwave, freezing can be used.But these therapies have abuse at present
Trend, outpatient service be frequently seen because the serious hyperplasia of the pharyngeal scar of Post operation, contracture and aggravation comes medical patient.Chronic pharynx
The scorching cause of disease is complex, the normal recurrent exerbation of the state of an illness, does not recover for a long time, is acquired a certain degree of difficulty in treatment, very refractory to be cured, and can only be slow
Symptom is solved, at present, the traditional Chinese medical science can improve the state of an illness in terms of chronic pharyngitis is treated, compared with doctor trained in Western medicine.
The content of the invention
For above-mentioned deficiency of the prior art, the invention provides a kind of composition containing loquat flower and application, system
Standby technique is simple, good effect, has no side effect safely.
The above-mentioned purpose of the present invention is achieved by the following technical programs.
A kind of composition containing loquat flower, is made up of each component of following parts by weight：25~35 parts of loquat flower, punching
8~15 parts of lotus, 5~12 parts of Rabdosia rubescens, 5~10 parts of honeysuckle.
The present invention also provides a kind of preparation method of described composition containing loquat flower, comprises the following steps：
S1. the loquat flower that fresh, the nothing of the parts by weight full-bloom stage are gone mouldy is chosen, is cleaned, under the conditions of 20~25 DEG C
Dry to water content below 5%；Crush, cross 20 eye mesh screens, add the edible ethanol solution that mass concentration is 30~50% and enter
Row extraction, the two solid-to-liquid ratio are 1:10~1:15,40~65 DEG C of Extracting temperature, extract 2~4 times, 2~3 hours every time, suction filtration took
Filtrate；Merging filtrate, it is concentrated under reduced pressure, 30~40 DEG C of thickening temperature, be concentrated into original volume 10~15% obtain loquat flower extractum A；
S2. the Herba Andrographitis of the parts by weight, Rabdosia rubescens, honeysuckle are chosen, is cleaned, dried under the conditions of 20~25 DEG C to
Water content is below 5%；Crush, cross 30 eye mesh screens, add the edible ethanol solution that mass concentration is 30~50% and carry out ultrasound
Extract, 10~15% that original volume is concentrated under reduced pressure into after suction filtration obtain mixed extract B；
S3. mixed extract B obtained by loquat flower extractum A obtained by step S1 and step S2 is mixed as active component, added
Pharmaceutically acceptable auxiliary material or auxiliary material composition is added to be prepared into preparation.
Preferably, a kind of preparation method of described composition containing loquat flower, it is characterised in that the preparation method
Extracting temperature in step S1 is 45~55 DEG C.
A kind of described composition containing loquat flower, the formulation of the composition is oral liquid, capsule or oral buccal tablet
In any one.
A kind of described composition containing loquat flower is preparing the application in treating pharyngitis medicine.
Preferably, the purposes of described a kind of composition containing loquat flower, described medicine are treatment chronic pharyngitis
Medicine.
Compared with prior art, beneficial effect of the present invention is：Present composition compatibility is reasonable, and preparation process is without high
Temperature, the bioactive ingredients of plant can be retained to greatest extent, the treatment pharyngitis medicine prepared using the present composition, especially
It is treatment chronic pharyngitis, drug effect is substantially better than existing preparation, and controllability is strong, and a kind of new selection is provided for clinic, and raw
Production cost is low, and preparation method is simple, is easy to industrialized production；A variety of formulations, convenient to take, property of medicine temperature can be made as needed
With raw material is natural food materials, is had no toxic side effect.
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.Unless stated otherwise, the reagent of the invention used, method and apparatus is the art conventional reagent, methods
And equipment.
Mode is preferably carried out as one kind, a kind of preparation method of the composition containing loquat flower, is comprised the following steps：
S1. the loquat flower that fresh, the nothing of the parts by weight full-bloom stage are gone mouldy is chosen, is cleaned, under the conditions of 20~25 DEG C
Dry to water content below 5%；Crush, cross 20 eye mesh screens, add the edible ethanol solution that mass concentration is 30~50% and enter
Row extraction, the two solid-to-liquid ratio are 1:10~1:15,40~65 DEG C of Extracting temperature, extract 2~4 times, 2~3 hours every time, suction filtration took
Filtrate；Merging filtrate, it is concentrated under reduced pressure, 30~40 DEG C of thickening temperature, be concentrated into original volume 10~15% obtain loquat flower extractum A；
S2. the Herba Andrographitis of the parts by weight, Rabdosia rubescens, honeysuckle are chosen, is cleaned, dried under the conditions of 20~25 DEG C to
Water content is below 5%；Crush, cross 30 eye mesh screens, add the edible ethanol solution that mass concentration is 30~50% and carry out ultrasound
Extract, 10~15% that original volume is concentrated under reduced pressure into after suction filtration obtain mixed extract B；
S3. mixed extract B obtained by loquat flower extractum A obtained by step S1 and step S2 is mixed as active component, added
Pharmaceutically acceptable auxiliary material or auxiliary material composition is added to be prepared into preparation.
It is furthermore preferred that a kind of preparation method of described composition containing loquat flower, in the preparation method step S1
Extracting temperature be 45~55 DEG C.
A kind of formulation of composition containing loquat flower described in embodiment is oral liquid, capsule or oral
Any one in lozenge.
The inventive method is further described by taking specific implementation condition as an example below.
Embodiment 1
A kind of composition containing loquat flower, is made up of each component of following parts by weight：30 parts of loquat flower, Herba Andrographitis 12
Part, 8 parts of Rabdosia rubescens, 8 parts of honeysuckle.
A kind of preparation method of described composition containing loquat flower, comprises the following steps：
S1. the loquat flower that fresh, the nothing of the parts by weight full-bloom stage are gone mouldy is chosen, is cleaned, under the conditions of 20~25 DEG C
Dry to water content below 5%；Crush, cross 20 eye mesh screens, add the edible ethanol solution that mass concentration is 40% and carried
Take, the two solid-to-liquid ratio is 1:12,45 DEG C of Extracting temperature, extract 3 times, 2 hours every time, suction filtration took filtrate；Merging filtrate, decompression are dense
Contracting, 35 DEG C of thickening temperature, be concentrated into original volume 10% obtain loquat flower extractum A；
S2. the Herba Andrographitis of the parts by weight, Rabdosia rubescens, honeysuckle are chosen, is cleaned, dried under the conditions of 20~25 DEG C to
Water content is below 5%；Crush, cross 30 eye mesh screens, add the edible ethanol solution that mass concentration is 40% and carry out ultrasonic extraction,
10% that original volume is concentrated under reduced pressure into after suction filtration obtains mixed extract B；
S3. mixed extract B obtained by loquat flower extractum A obtained by step S1 and step S2 is mixed as active component, added
Pharmaceutically acceptable auxiliary material or auxiliary material composition is added to be prepared into preparation.
Embodiment 2
A kind of composition containing loquat flower, is made up of each component of following parts by weight：25 parts of loquat flower, Herba Andrographitis 8
Part, 5 parts of Rabdosia rubescens, 5 parts of honeysuckle.
Preparation method is same as Example 1.
Embodiment 3
A kind of composition containing loquat flower, is made up of each component of following parts by weight：35 parts of loquat flower, Herba Andrographitis 15
Part, 12 parts of Rabdosia rubescens, 10 parts of honeysuckle.
Preparation method is same as Example 1.
Embodiment 4
A kind of composite formula containing loquat flower is same as Example 1, and difference is preparation method.
A kind of preparation method of described composition containing loquat flower, is concretely comprised the following steps：The parts by weight are chosen to contain
Florescence it is fresh, without go mouldy loquat flower, Herba Andrographitis, Rabdosia rubescens, honeysuckle, clean, dried under the conditions of 20~25 DEG C to containing
Water is below 5%；Crush, cross 20 eye mesh screens, add the edible ethanol solution that mass concentration is 40% and extracted, the two is solid
Liquor ratio is 1:10,65 DEG C of Extracting temperature, extract 3 times, 2 hours every time, suction filtration took filtrate；Merging filtrate, it is concentrated under reduced pressure, concentration temperature
35 DEG C of degree, be concentrated into original volume 10% extractum A as active component, add pharmaceutically acceptable auxiliary material or auxiliary material into
Divide and be prepared into preparation.
Comparative example 1
A kind of composition containing loquat flower, is made up of each component of following parts by weight：Without Herba Andrographitis, Rabdosia rubescens, institute
State 20 parts of loquat flower, 12 parts of honeysuckle.
Preparation method is same as Example 1.
Comparative example 2
A kind of composite formula containing loquat flower is same as Example 1, and difference is preparation method.
A kind of preparation method of described composition containing loquat flower, comprises the following steps：
S1. the loquat flower that fresh, the nothing of the parts by weight full-bloom stage are gone mouldy is chosen, is cleaned, under the conditions of 20~25 DEG C
Dry to water content below 5%；Crush, cross 20 eye mesh screens, add the edible ethanol solution that mass concentration is 80% and carried
Take, the two solid-to-liquid ratio is 1:12,50 DEG C of Extracting temperature, extract 3 times, 2.5 hours every time, suction filtration took filtrate；Merging filtrate, decompression
Concentration, 35 DEG C of thickening temperature, be concentrated into original volume 10% obtain loquat flower extractum A；
S2. the Herba Andrographitis of the parts by weight, Rabdosia rubescens, honeysuckle are chosen, is cleaned, dried under the conditions of 20~25 DEG C to
Water content is below 5%；Crush, cross 30 eye mesh screens, add the edible ethanol solution that mass concentration is 95% and carry out ultrasonic extraction,
10% that original volume is concentrated under reduced pressure into after suction filtration obtains mixed extract B；
S3. mixed extract B obtained by loquat flower extractum A obtained by step S1 and step S2 is mixed as active component, added
Pharmaceutically acceptable auxiliary material or auxiliary material composition is added to be prepared into preparation.
Application examples 1
Mouse 160 is taken, after each sex is by body weight layering, then is randomly divided into 8 groups, every group 20, jenny about 12,
Buck about 8.
1st group is blank control group, and carboxymethylcellulose sodium solution is given by 20ml gavages；2nd group is positive controls
(Anticol group), give cough in federation by 12mg (codeine)/kgd gavages and reveal, equivalent to the 20 of people's clinic consumption per day
Again (medicine is only given before with ammoniacal liquor modeling twice)；3rd, 4,5,6,7,8 group be respectively embodiment 1~4 and comparative example 1~
2 preparation, administered volume are 20ml/kgd, are respectively administered once sooner or later daily, successive administration 7 days, the 4th day Germicidal efficacy.
Last time is administered, and after a hour, in preferable environment of divulging information, small white mouse is put into the beaker that volume is 1000ml
In, beaker mouth preservative film is closed.50ml ammoniacal liquor (13%) is added in ultrasonic atomizer, and the insertion of its outlet is fresh-keeping
(airing hole is stayed on preservative film) in film, after being continually fed into ammonia (spray velocity is maximum) 60s, close ultrasonic mist immediately
Change device and open preservative film rapidly, make wherein ammonia diffusion.
While ammonia is passed through, start timing with stopwatch, record small white mouse cough latent period (by being passed through ammonia to
Mouse occur cough required for time be incubation period) and three minutes in cough number.Cough is shown as：Magnify mouth or open
With cough, visible contraction of abdominal muscle during osculum.
By a large amount of repeated experiments, acquired results are handled eventually through SPSS softwares, and carry out significance test.
As a result such as following table：
Application examples 2
Choose and suffer from patients with chronic pharyngitis 300 through clinical diagnosis, at 35~40 years old age, be divided into 6 groups at random, take respectively
With the preparation of embodiment 1~4 and comparative example 1~2, three times per day, continuously take 7 days.Judgment criteria：Cure completely and (feel disease
Shape and sign disappear)；Effective (subjective symptoms largely disappears, and sign is clearly better), it is invalid.Result of the test such as following table：
| Patient populations/example | Effective/example | Improvement/example | Invalid/example | Effective percentage/% | |
| Embodiment 1 | 50 | 48 | 2 | 0 | 100 |
| Embodiment 2 | 50 | 46 | 4 | 0 | 100 |
| Embodiment 3 | 50 | 45 | 5 | 0 | 100 |
| Embodiment 4 | 50 | 38 | 8 | 4 | 92 |
| Comparative example 1 | 50 | 33 | 9 | 8 | 84 |
| Comparative example 2 | 50 | 30 | 11 | 9 | 82 |
Found through clinical investigation, a kind of optimize technique extraction, composition medicine containing loquat flower of the invention is being treated
Pharyngitis, chronic pharyngitis is especially treated, there is significant effect, the pharmacology mutually cooperateed between each component can be played well and made
With.
It is described above, it is only the explanation embodiment of the present invention, formal and substantial limitation not any to the present invention,
It should be pointed out that for those skilled in the art, on the premise of the inventive method is not departed from, that makes some changes
Enter and supplement and also should be regarded as protection scope of the present invention.All those skilled in the art, do not depart from spirit of the invention and
In the case of scope, a little change, modification and the equivalent variations developed made using disclosed above technology contents, it is
The equivalent embodiment of the present invention；Meanwhile any equivalent variations that all substantial technologicals according to the present invention are done to above-described embodiment
Change, modification and differentiation, still fall within protection scope of the present invention.
Claims (6)
1. a kind of composition containing loquat flower, it is characterised in that be made up of each component of following parts by weight：Loquat flower 25~
35 parts, 8~15 parts of Herba Andrographitis, 5~12 parts of Rabdosia rubescens, 5~10 parts of honeysuckle.
2. the preparation method of a kind of composition containing loquat flower described in claim 1, it is characterised in that including following step
Suddenly：
S1. the loquat flower that fresh, the nothing of the parts by weight full-bloom stage are gone mouldy is chosen, cleans, is dried under the conditions of 20~25 DEG C
To water content below 5%；Crush, cross 20 eye mesh screens, add the edible ethanol solution that mass concentration is 30~50% and carried
Take, the two solid-to-liquid ratio is 1:10~1:15,40~65 DEG C of Extracting temperature, extract 2~4 times, 2~3 hours every time, suction filtration took filter
Liquid；Merging filtrate, it is concentrated under reduced pressure, 30~40 DEG C of thickening temperature, be concentrated into original volume 10~15% obtain loquat flower extractum A；
S2. the Herba Andrographitis of the parts by weight, Rabdosia rubescens, honeysuckle are chosen, cleans, is dried under the conditions of 20~25 DEG C to aqueous
Amount is below 5%；Crush, cross 30 eye mesh screens, add the edible ethanol solution that mass concentration is 30~50% and carry out ultrasonic extraction,
10~15% that original volume is concentrated under reduced pressure into after suction filtration obtain mixed extract B；
S3. mixed extract B obtained by loquat flower extractum A obtained by step S1 and step S2 is mixed as active component, adds medicine
Acceptable auxiliary material or auxiliary material composition is prepared into preparation on.
A kind of 3. preparation method of composition containing loquat flower according to claim 2, it is characterised in that the preparation
Extracting temperature in method and step S1 is 45~55 DEG C.
A kind of 4. composition of composition containing loquat flower according to claim 1, it is characterised in that the composition
Formulation be oral liquid, capsule or oral buccal tablet in any one.
5. a kind of composition containing loquat flower described in claim 1 is preparing the application in treating pharyngitis medicine.
6. a kind of composition containing loquat flower according to claim 5 is preparing the application in treating pharyngitis medicine, its
It is characterised by, described medicine is the medicine for treating chronic pharyngitis.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710908428.XA CN107496533A (en) | 2017-09-29 | 2017-09-29 | A kind of composition containing loquat flower and application |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710908428.XA CN107496533A (en) | 2017-09-29 | 2017-09-29 | A kind of composition containing loquat flower and application |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101366844A (en) * | 2008-09-28 | 2009-02-18 | 成都青山利康药业有限公司 | New use of loquat flower and its extract |
| CN103536641A (en) * | 2013-08-06 | 2014-01-29 | 柳州市工人医院 | Anti-inflammatory medicament |
-
2017
- 2017-09-29 CN CN201710908428.XA patent/CN107496533A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101366844A (en) * | 2008-09-28 | 2009-02-18 | 成都青山利康药业有限公司 | New use of loquat flower and its extract |
| CN103536641A (en) * | 2013-08-06 | 2014-01-29 | 柳州市工人医院 | Anti-inflammatory medicament |
Non-Patent Citations (2)
| Title |
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| 家玉很好: "冬凌草一起泡水喝能治疗咽炎？", 《HTTPS://IASK.SINA.COM.CN/B/5Z9HOIOSAM3.HTML》 * |
| 董淑霞: "复方双花片治疗慢性咽炎90例", 《陕西中医》 * |
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Application publication date: 20171222 |