CN107468924A - One kind washes ear fluid and preparation method thereof - Google Patents
One kind washes ear fluid and preparation method thereof Download PDFInfo
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Abstract
The present invention provides one kind and washes ear fluid and preparation method thereof, mainly using fresh honewort, fresh sweet wormwood, fresh Herba Andrographitis, fresh shaddock leaf, fresh peppermint be careless, fresh kiss-me, fresh kudzu, fresh lophatherum gracile, flavour amino acid, fresh honeysuckle rattan, fresh dandelion is raw material, through just distillation, decoct, the process such as redistillation is made.It is preferable that this washes ear fluid assimilation effect, bactericidal anti-inflammatory effect is obvious, strong adaptability, bactericidal antiphlogistic effect is played to most of ear inflammation, and is formulated rationally, manufacture craft is simple, it is safe, toxic side effect and other adverse reactions are not found, and there is good development prospect, be suitable for large range promotion use.
Description
【Technical field】
The present invention relates to pharmaceutical technology field, and ear fluid and preparation method thereof is washed more particularly, to one kind.
【Background technology】
Ear is the important hearing organ of the mankind, and ear transmits extraneous vibration wave arrival ear-drum by bending auricle hole,
Nerve information is developed into by ear vibration of membrane and forms the sense of hearing.The opening structure of ear easily makes to turn into corner or spot as yet untouched by a clean-up campaign inside ear,
The dirt such as dust of accumulation is easy to make to produce infection inflammation in ear in ear.For all kinds of infection inflammations, modern medicine master
To be treated with Bactericidal medicine, such as using antibiotic, though can reach the effect of analgesic antiphlogistic, the germ of ear is not removed
Go out, the case for repeating breaking-out is a lot.Simultaneously as various antibiotic extensive uses, antibody-resistant bacterium increase, cause chemical antibacterial
The effective unobvious of drops for ear agent, some aminoglycoside antibiotics produce direct toxic action to inner ear, damage cochlea, influence
Hearing, some patients are caused drug-induced deafness occur, and external Chinese medicament is mostly scattered, cream, oil formulation, patient is also easy to produce ear after
Dirt and be difficult to eliminate, hearing is influenceed, so that clinical application is restricted.
Patent CN106668256A discloses a kind of strong doctor and washes ear fluid, and this washes ear fluid so that fresh peppermint is careless, fresh shaddock leaf, fresh mill
Disk is careless, fresh sweet wormwood borneol etc. is raw material.Although this washes ear fluid with certain bactericidal anti-inflammatory effect, because its formula is simple,
The infection symptoms such as otitis media suppurative are lacked with effective control, so as to have impact on therapeutic effect.
【The content of the invention】
It is contemplated that overcome the deficiencies in the prior art, there is provided one kind formula is reasonable, and manufacture craft is simple, secondary without any poison
Effect, assimilation effect is preferable, and bactericidal antiphlogistic effect can be played to most of ear inflammation washes ear fluid.
In order to realize the above object the technical scheme that the present invention takes is：
One kind washes ear fluid, is made up of the raw material components of following parts by weight：It is fresh honewort 12-14 parts, fresh sweet wormwood 8-10 parts, fresh
Herba Andrographitis 8-10 parts, fresh shaddock leaf 7-9 parts, fresh peppermint grass 4-6 parts, fresh kiss-me 6-8 parts, fresh kudzu 3-5 parts, fresh lophatherum gracile 3-
5 parts, flavour amino acid 3-5 parts, fresh honeysuckle rattan 3-5 parts, fresh dandelion 1-3 parts.
Preferably, it is described to wash ear fluid, it is made up of the raw material components of following parts by weight：Fresh 13 parts of honewort, 9 parts of fresh sweet wormwood,
Fresh 9 parts of Herba Andrographitis, 8 parts of fresh shaddock leaf, 5 parts of fresh peppermint grass, 7 parts of fresh kiss-me, 4 parts of fresh kudzu, 4 parts of fresh lophatherum gracile, fresh fish raw meat
4 parts of grass, 4 parts of fresh honeysuckle rattan, 2 parts of fresh dandelion.
The preparation method for washing ear fluid follows these steps to carry out：
(1) just distill：By fresh honewort, fresh sweet wormwood, fresh Herba Andrographitis, fresh shaddock leaf, fresh peppermint be careless, fresh kiss-me, fresh Pueraria lobota
Rattan, fresh lophatherum gracile, flavour amino acid, fresh honeysuckle rattan, fresh dandelion are cleaned according to proportioning, chopping, add water to distill, water used
For 7-9 times of raw materials used medicine gross weight, just distillate is collected；
(2) decoct：The dregs of a decoction of first distilation steps are added to the water of 5-7 times of total raw material weight, boils, is cooked by slow fire with high heat
30-40 minutes, separation and Extraction decoction liquor；
(3) redistillation：The just distillate is mixed with the decoction liquor, redistillation is carried out, collects re-distilled liquid, produce
It is described to wash ear fluid.
It is provided by the invention to wash ear fluid, there is advantages below：
(1) assimilation effect is preferable, and bactericidal anti-inflammatory effect is obvious, strong adaptability, and playing sterilization to most of ear inflammation disappears
Inflammation effect；
(2) formula is reasonable, and manufacture craft is simple, safe, does not find toxic side effect and other adverse reactions, has very
Good development prospect, is suitable for large range promotion use.
【Embodiment】
The following examples can help those skilled in the art that the present invention is more completely understood, but cannot be with any
Mode limits the present invention.
Embodiment 1
One kind washes ear fluid, is made up of the raw material components of following parts by weight：Fresh 12 parts of honewort, 8 parts of fresh sweet wormwood, fresh Herba Andrographitis
8 parts, it is 7 parts of fresh shaddock leaf, 4 parts of fresh peppermint grass, 6 parts of fresh kiss-me, 3 parts of fresh kudzu, 3 parts of fresh lophatherum gracile, 3 parts of flavour amino acid, fresh
3 parts of Honeysuckle bine, 1 part of fresh dandelion.
The preparation method for washing ear fluid follows these steps to carry out：
(1) just distill：By fresh honewort, fresh sweet wormwood, fresh Herba Andrographitis, fresh shaddock leaf, fresh peppermint grass, fresh kiss-me, fresh Pueraria lobota
Rattan, fresh lophatherum gracile, flavour amino acid, fresh honeysuckle rattan, fresh dandelion are cleaned according to proportioning, chopping, add water to distill, water used
For 7 times of raw materials used medicine gross weight, just distillate is collected；
(2) decoct：The dregs of a decoction of first distilation steps are added to the water of 5 times of total raw material weight, boils with high heat, is cooked by slow fire 30
Minute, separation and Extraction decoction liquor；
(3) redistillation：The just distillate is mixed with the decoction liquor, redistillation is carried out, collects re-distilled liquid, produce
It is described to wash ear fluid.
Embodiment 2
One kind washes ear fluid, is made up of the raw material components of following parts by weight：Fresh 13 parts of honewort, 9 parts of fresh sweet wormwood, fresh Herba Andrographitis
9 parts, it is 8 parts of fresh shaddock leaf, 5 parts of fresh peppermint grass, 7 parts of fresh kiss-me, 4 parts of fresh kudzu, 4 parts of fresh lophatherum gracile, 4 parts of flavour amino acid, fresh
4 parts of Honeysuckle bine, 2 parts of fresh dandelion.
The preparation method for washing ear fluid follows these steps to carry out：
(1) just distill：By fresh honewort, fresh sweet wormwood, fresh Herba Andrographitis, fresh shaddock leaf, fresh peppermint be careless, fresh kiss-me, fresh Pueraria lobota
Rattan, fresh lophatherum gracile, flavour amino acid, fresh honeysuckle rattan, fresh dandelion are cleaned according to proportioning, chopping, add water to distill, water used
For 8 times of raw materials used medicine gross weight, just distillate is collected；
(2) decoct：The dregs of a decoction of first distilation steps are added to the water of 6 times of total raw material weight, boils with high heat, is cooked by slow fire 35
Minute, separation and Extraction decoction liquor；
(3) redistillation：The just distillate is mixed with the decoction liquor, redistillation is carried out, collects re-distilled liquid, produce
It is described to wash ear fluid.
Embodiment 3
One kind washes ear fluid, is made up of the raw material components of following parts by weight：Fresh 14 parts of honewort, 10 parts of fresh sweet wormwood, fresh punching
10 parts of lotus, 9 parts of fresh shaddock leaf, fresh peppermint grass 6 parts, 8 parts of fresh kiss-me, 5 parts of fresh kudzu, 5 parts of fresh lophatherum gracile, 5 parts of flavour amino acid,
5 parts of fresh honeysuckle rattan, 3 parts of fresh dandelion.
The preparation method for washing ear fluid follows these steps to carry out：
(1) just distill：By fresh honewort, fresh sweet wormwood, fresh Herba Andrographitis, fresh shaddock leaf, fresh peppermint be careless, fresh kiss-me, fresh Pueraria lobota
Rattan, fresh lophatherum gracile, flavour amino acid, fresh honeysuckle rattan, fresh dandelion are cleaned according to proportioning, chopping, add water to distill, water used
For 9 times of raw materials used medicine gross weight, just distillate is collected；
(2) decoct：The dregs of a decoction of first distilation steps are added to the water of 7 times of total raw material weight, boils with high heat, is cooked by slow fire 40
Minute, separation and Extraction decoction liquor；
(3) redistillation：The just distillate is mixed with the decoction liquor, redistillation is carried out, collects re-distilled liquid, produce
It is described to wash ear fluid.
Experimental example
The present inventor is tested by drug effect contrasts by long-term substantial amounts of experimental study, constantly changes, adjusts bulk drug
Species and dosage, selected, determine that the present invention washes the bulk drug species and dosage of ear fluid, final be made washes ear fluid in treatment ear
Aspect of inflammation has superior effect.During research experiment, the inventors discovered that, the change pair of bulk drug species and dosage
The drug effect that the present invention washes ear fluid has large effect.The part contrast experiment that research process are set forth below illustrates：
1st, the effect of bulk drug species washes ear fluid to the present invention influences experiment
A of the present invention：Take the technical scheme of the embodiment of the present invention 2；
Contrast groups A1：Raw material does not use fresh sweet wormwood, and other raw materials, dosage and preparation method are the same as embodiment 2；
Contrast groups A2：Raw material does not use fresh Herba Andrographitis, and other raw materials, dosage and preparation method are the same as embodiment 2；
Contrast groups A3：Bulk drug is not using fresh sweet wormwood, fresh Herba Andrographitis, other raw materials, dosage and the same embodiment of preparation method
2；
Contrast groups A4：For bulk drug using having antibacterial action, the fresh Radix Isatidis of removing pattogenic heat from the blood and toxic material from the body effect replaces fresh sweet wormwood, and fresh
Radix Isatidis takes 9 parts, and other raw materials, dosage and preparation method are the same as embodiment 2；
Contrast groups A5：For bulk drug using having heat-clearing and damp-drying drug, the Chinese twinleaf rhizome of purging intense heat and detonicating effect replaces fresh Herba Andrographitis, and fresh
The coptis takes 9 parts, and other raw materials, dosage and preparation method are the same as embodiment 2；
Contrast groups A6：Bulk drug replaces fresh sweet wormwood, fresh Herba Andrographitis, and fresh Radix Isatidis respectively using fresh Radix Isatidis and Chinese twinleaf rhizome
9 parts, 9 parts of Chinese twinleaf rhizome, other raw materials, dosage and preparation method are the same as embodiment 2；
Prepared respectively according to the technical scheme of above each group and wash ear fluid, then will respectively washed ear fluid and be applied to treatment ear inflammation
Disease, then ear fluid is washed to each group and tested using Comparison of therapeutic, specific method is as follows：
The object of observation：140 sufferers of osteoporosis face are chosen, 7 groups is randomly divided into, every group 20, above each group is respectively adopted
Obtained ear fluid of washing carries out Ureteral Calculus.The course of disease, the degrees of symptoms of each group case are basically identical, no significant difference, have
Comparativity.
Medication, observational technique：External application, 3 times a day, takes 50-100g to wash ear fluid every time, is dipped with disinfecting cotton swab and cleans trouble
Place, 3 days be a course for the treatment of, and a length of 3 courses for the treatment of during observation, patient recovers during observation, discontinues medication, remaining not more patient
Continue medication Ureteral Calculus.
Treatment standard：Cure：The illness of ear inflammation disappears, afterwards no relapse；Effectively：The illness of ear inflammation is good
Turn；It is invalid：The illness of ear inflammation is unchanged or change is slight.
Comparison of therapeutic result：Ureteral Calculus is carried out to each group case respectively, acquired results are as shown in table 1 below：
The clinical observation result of table 1 (A groups)
| Group | Cure | Effectively | It is invalid | Total effective rate |
| A of the present invention | 17 | 2 | 1 | 95% |
| Contrast groups A1 | 12 | 3 | 5 | 75% |
| Contrast groups A2 | 11 | 4 | 5 | 75% |
| Contrast groups A3 | 10 | 3 | 7 | 65% |
| Contrast groups A4 | 10 | 5 | 5 | 75% |
| Contrast groups A5 | 12 | 2 | 6 | 70% |
| Contrast groups A6 | 13 | 3 | 4 | 80% |
From upper table 1, relative to each contrast groups, ear fluid is washed made from the embodiment of the present invention 2 and is used to treat ear inflammation
With it is more superior the effect of, its effective percentage up to 95%.It can be seen that the species of feed change medicine, even uses similar work(
The bulk drug of effect is replaced, and can substantially reduce the final drug effect that the present invention washes ear fluid.
2nd, the effect of raw material survival dose washes ear fluid to the present invention influences experiment
B of the present invention：Using the technical scheme for taking the embodiment of the present invention 2；
Contrast groups B1：The similar embodiment 2 of bulk drug kind, but fresh sweet wormwood (is more than the fresh sweet wormwood of the present invention with measuring 12 parts
Research on maximum utilized quantity), the dosage and preparation method of other raw materials are the same as embodiment 2；
Contrast groups B2：The similar embodiment 2 of bulk drug kind, but fresh sweet wormwood (is less than the fresh sweet wormwood of the present invention most with measuring 7 parts
Small dosage), the dosage and preparation method of other raw materials are the same as embodiment 2；
Contrast groups B3：The similar embodiment 2 of bulk drug kind, but fresh Herba Andrographitis (is more than the fresh punching of the present invention with measuring 11 parts
The research on maximum utilized quantity of lotus), the dosage and preparation method of other raw materials are the same as embodiment 2；
Contrast groups B4：The similar embodiment 2 of bulk drug kind, but fresh Herba Andrographitis (is less than the fresh Herba Andrographitis of the present invention with measuring 7 parts
Minimum amount), the dosage and preparation method of other raw materials are the same as embodiment 2；
Contrast groups B5：The similar embodiment 2 of bulk drug kind, but the dosage of fresh sweet wormwood, fresh Herba Andrographitis takes 14 parts and 14 parts respectively
(both dosages are all higher than both research on maximum utilized quantities in the present invention), the dosage and preparation method of other raw materials are the same as embodiment 2；
Contrast groups B6：The similar embodiment 2 of bulk drug kind, but the dosage of fresh sweet wormwood, fresh Herba Andrographitis takes 6 parts and 6 part (two respectively
Person's dosage is respectively less than both minimum amounts in the present invention), the dosage and preparation method of other raw materials are the same as embodiment 2；
Prepared respectively according to the technical scheme of above each group and wash ear fluid, then will respectively washed ear fluid and be applied to treatment ear inflammation
Disease, then ear fluid is washed to each group and tested using Comparison of therapeutic, specific method washes the treatment of ear fluid with bulk drug species to the present invention
The method that effect influences experiment is identical.Acquired results are as shown in table 2 below：
The clinical observation result of table 2 (B groups)
| Group | Cure | Effectively | It is invalid | Total effective rate |
| B of the present invention | 18 | 1 | 1 | 95% |
| Contrast groups B1 | 11 | 4 | 5 | 75% |
| Contrast groups B2 | 11 | 3 | 6 | 70% |
| Contrast groups B3 | 13 | 3 | 4 | 80% |
| Contrast groups B4 | 11 | 3 | 6 | 70% |
| Contrast groups B5 | 12 | 1 | 7 | 65% |
| Contrast groups B6 | 10 | 2 | 8 | 60% |
From upper table 2, relative to each contrast groups, ear fluid is washed made from the embodiment of the present invention 2 and is used to treat ear inflammation
With it is more superior the effect of, its effective percentage up to 95%.It can be seen that the effect of dosage of material medicine washes ear fluid to the present invention has
There is important influence, dosage can reduce final the effect of washing ear fluid beyond the amount ranges of the present invention.
In summary, the species of bulk drug and dosage have a major impact to the drug effect of the invention for washing ear fluid, reduce or replace
Wherein certain taste medicine is changed, or raw material survival dose exceeds the amount ranges of the present invention, can largely effect on the medicine of bulk drug of the present invention
Effect.
In addition, by clinical verification for many years, ear fluid is washed obtained by the present invention, assimilation effect is preferable, bactericidal anti-inflammatory effect
Substantially, strong adaptability, bactericidal antiphlogistic effect is played to most of ear inflammation；And mild in medicine property and, it is securely and reliably, secondary without any poison
Effect.Several exemplaries are set forth below and are explained its using effect.
Model case：
Case 1：Tang, female, 22 years old.Main suit：These last few days ear starts to itch, have mild pain, when have liquid outflow, pass through
Examination in hospital is diagnosed as mycotic duct inflammation.Wash ear fluid using the present invention afterwards to be treated, external application 2 days, the pain of patient
Shape is obviously improved, and continues external application 3 days, and illness disappears, got well, one month no relapse of follow-up.
Case 2：Zhao, man, 3 years old.Main suit：Before three days, the child starts frequently to scratch ear, as the uncomfortable sample of ear
Son, and 37.8 degree of low fever, admission diagnosis is otitis media suppurative.Wash ear fluid using the present invention afterwards to be treated, external application 3
My god, patient brings down a fever, and continues external application 1 day, and illness disappears, got well, one month no relapse of follow-up.
Case 3：Certain is gone into business, female, 48 years old.Main suit：Gone swimming before two days pond swimming when ear entered water, find ear within second day
Start to itch, it is a little red and swollen behind ear, ear furuncle is diagnosed as on inspection.Wash ear fluid using the present invention afterwards to be treated, external application 3
My god, the red and swollen symptom of patient disappears, and continues external application 2 days, gets well, one month no relapse of follow-up.
Although above the present invention is described in detail with a general description of the specific embodiments,
On the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Cause
This, these modifications or improvements, belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (3)
1. one kind washes ear fluid, it is characterised in that is made up of the raw material components of following parts by weight：Fresh honewort 12-14 parts, fresh sweet wormwood
8-10 parts, fresh Herba Andrographitis 8-10 parts, fresh shaddock leaf 7-9 parts, fresh peppermint grass 4-6 parts, fresh kiss-me 6-8 parts, fresh kudzu 3-5 parts,
Fresh lophatherum gracile 3-5 parts, flavour amino acid 3-5 parts, fresh honeysuckle rattan 3-5 parts, fresh dandelion 1-3 parts.
2. one kind according to claim 1 washes ear fluid, it is characterised in that is made up of the raw material components of following parts by weight：It is fresh
13 parts of honewort, 9 parts of fresh sweet wormwood, 9 parts of fresh Herba Andrographitis, 8 parts of fresh shaddock leaf, 5 parts of fresh peppermint grass, 7 parts of fresh kiss-me, fresh kudzu 4
Part, 4 parts of fresh lophatherum gracile, 4 parts of flavour amino acid, 4 parts of fresh honeysuckle rattan, 2 parts of fresh dandelion.
3. a kind of preparation method for washing ear fluid according to claim 1 or 2, it is characterised in that comprise the following steps：
(1) just distill：By fresh honewort, fresh sweet wormwood, fresh Herba Andrographitis, fresh shaddock leaf, fresh peppermint be careless, fresh kiss-me, fresh kudzu, fresh
Lophatherum gracile, flavour amino acid, fresh honeysuckle rattan, fresh dandelion are cleaned according to proportioning, chopping, add water to distill, water used is institute
With 7-9 times of bulk drug gross weight, just distillate is collected；
(2) decoct：The dregs of a decoction of first distilation steps are added to the water of 5-7 times of total raw material weight, boils with high heat, is cooked by slow fire 30-
40 minutes, separation and Extraction decoction liquor；
(3) redistillation：The just distillate is mixed with the decoction liquor, redistillation is carried out, collects re-distilled liquid, is produced described
Wash ear fluid.
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| CN201710681664.2A CN107468924A (en) | 2017-08-10 | 2017-08-10 | One kind washes ear fluid and preparation method thereof |
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| CN201710681664.2A CN107468924A (en) | 2017-08-10 | 2017-08-10 | One kind washes ear fluid and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110585384A (en) * | 2019-10-11 | 2019-12-20 | 文莉 | Pharmaceutical composition for removing dampness and diminishing inflammation and preparation method and application thereof |
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| US20060280809A1 (en) * | 2005-06-14 | 2006-12-14 | Leshchiner Adele K | Anti-infective iodine based compositions for otic and nasal use |
| CN106668256A (en) * | 2015-11-06 | 2017-05-17 | 庞锦霞 | Zhuang medicine ear washing liquid |
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2017
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060280809A1 (en) * | 2005-06-14 | 2006-12-14 | Leshchiner Adele K | Anti-infective iodine based compositions for otic and nasal use |
| CN106668256A (en) * | 2015-11-06 | 2017-05-17 | 庞锦霞 | Zhuang medicine ear washing liquid |
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| Title |
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| 孙青红: "分泌性中耳炎的研究进展", 《中国民族民间医药》 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110585384A (en) * | 2019-10-11 | 2019-12-20 | 文莉 | Pharmaceutical composition for removing dampness and diminishing inflammation and preparation method and application thereof |
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