CN110585384A

CN110585384A - Pharmaceutical composition for removing dampness and diminishing inflammation and preparation method and application thereof

Info

Publication number: CN110585384A
Application number: CN201910963746.5A
Authority: CN
Inventors: 文莉
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-10-11
Filing date: 2019-10-11
Publication date: 2019-12-20

Abstract

The invention discloses a pharmaceutical composition for removing dampness and diminishing inflammation, a preparation method and application thereof, wherein the pharmaceutical composition comprises the following components: 2-8 parts of honeysuckle stem, 3-6 parts of bergenia purpurascens, 3-8 parts of herba silenes fortunei, 2-10 parts of pneumococcus, 3-9 parts of houttuynia cordata, 2-10 parts of radix cynanchi atrati, 4-10 parts of creeping liriope, 3-8 parts of Ainsliaea fragrans, 1-10 parts of ilex leaf, 4-10 parts of orange peel, 3-9 parts of Jianzhuifeng, 1-10 parts of dexamethasone, 1-6 parts of chlorphenamine maleate and 5-20 parts of Jianqu. Can be used for treating rheumatism, rheumatoid diseases, gout, otitis media, rhinitis, pharyngolaryngitis, tenosynovitis and heel inflammation, can be used for preparing products for preventing and/or treating the diseases, and provides an effective new scheme and a new strategy for treating rheumatism, rheumatoid diseases, gout and various inflammations.

Description

Pharmaceutical composition for removing dampness and diminishing inflammation and preparation method and application thereof

Technical Field

The invention relates to the field of pharmaceutical compositions, in particular to a pharmaceutical composition for removing dampness and diminishing inflammation, a preparation method and application thereof.

Background

With the continuous progress of medical technology, most diseases can be cured or controlled well, and the physical health condition and the life quality of people are greatly improved. However, some chronic diseases or inflammatory diseases are still difficult to cure radically, such as chronic diseases like rheumatism, rheumatoid diseases and gout, and inflammations like otitis media, rhinitis and tenosynovitis.

Patients with these diseases need to be nursed in daily life at ordinary times, sometimes need to take medicines for a long time to control the disease condition, and have side effects on the body of the patients in the past, involve organs of the patients such as liver and kidney, and are easy to relapse after careless treatment, thus seriously affecting physical and psychological health of the patients.

Therefore, it is important to develop a more effective, safer and less-side-effect drug for treating chronic diseases or inflammatory diseases such as rheumatism, rheumatoid diseases, gout and the like.

Disclosure of Invention

The invention mainly solves the technical problem of providing a composition which can effectively remove dampness and diminish inflammation and is used for preparing medicines for treating rheumatism, rheumatoid, gout and various inflammations.

In order to solve the technical problems, the invention adopts a technical scheme that:

the composition comprises the following components in parts by weight: 2-8 parts of honeysuckle stem, 3-6 parts of bergenia purpurascens, 3-8 parts of herba silenes fortunei, 2-10 parts of pneumococcus, 3-9 parts of houttuynia cordata, 2-10 parts of radix cynanchi atrati, 4-10 parts of creeping liriope, 3-8 parts of Ainsliaea fragrans, 1-10 parts of ilex leaf, 4-10 parts of orange peel, 3-9 parts of Jianzhuifeng, 1-10 parts of dexamethasone, 1-6 parts of chlorphenamine maleate and 5-20 parts of Jianqu.

In the treatment process of some chronic diseases or inflammatory diseases, a large amount of western medicines are often required to be taken for a long time, which causes great burden to organs such as liver, kidney and the like of a patient.

The pharmaceutical composition provided by the invention replaces a large amount of western medicines with the traditional Chinese medicine components, combines the traditional Chinese medicine and western medicine, has synergistic effect and better treatment effect, and is more beneficial to the body health of patients.

In the present invention, all the components are used in dry amounts.

The dry weight is the dry weight of the Chinese medicinal material dried by airing or baking.

Further, the composition comprises the following components in parts by weight: 6 parts of honeysuckle stem, 5 parts of bergenia purpurascens, 5 parts of herba sileris, 7 parts of pneumococcus, 4 parts of houttuynia cordata, 8 parts of radix cynanchi atrati, 8 parts of radix ophiopogonis, 6 parts of Ainsliaea fragrans, 4 parts of Chinese ilex leaf, 7 parts of orange peel, 4 parts of Jianhufeng, 2 parts of dexamethasone, 5 parts of chlorphenamine maleate and 10 parts of medicinal fermented mass.

The invention also provides a preparation method of the composition, which comprises the following steps: mixing caulis Lonicerae, rhizoma Seu herba Bergeniae, herba Rostellulariae, herba cor pulmonaris, herba Houttuyniae, radix seu folium Gaultheriae Forrestii, radix Ophiopogonis, herba Ainsliaeae Rubrinervis, folium Ilicis Purpureae, pericarpium Citri Tangerinae, JIANZHENGFENG, dexamethasone, chlorphenamine maleate, and Massa Medicata Fermentata.

The invention also provides a powder preparation which comprises the powder of the composition.

The invention also provides a preparation method of the powder, which comprises the following steps: (1) according to the weight parts, honeysuckle stem, bergenia, herba violae, cor pulmonale, houttuynia cordata, radix cynanchi wilfordii, creeping liriope, leprianum glaucescens, Chinese ilex leaf, orange peel, jiangzhuifeng, dexamethasone, chlorphenamine maleate and medicated leaven are taken; (2) pulverizing the components in the composition; (3) the components of the composition are mixed.

Wherein, the sequence of the operations of (1), (2) and (3) is not limited, namely, the components can be mixed and then the mixture can be crushed together, or the components can be respectively and independently crushed and then mixed; or mixing and crushing part of the components together, separately crushing part of the components, and finally mixing the components together to obtain powder.

Furthermore, the honeysuckle stem, the bergenia cordifolia, the kwan-yin herb, the cor pulmonale, the cordate houttuynia, the radix cynanchi wilfordii, the radix ophiopogonis, the lepriasis glauca, the Chinese ilex leaf, the orange peel and the jianghufeng are all crushed for at least three times.

The invention also provides application of the composition in preparing a product with the effects of removing dampness and diminishing inflammation.

Including but not limited to food, pharmaceutical, nutraceutical, and the like.

Further, the product is a product for preventing and/or treating one or more of rheumatism, rheumatoid diseases, gout and inflammatory diseases.

Further, the inflammation is selected from one or more of otitis media, rhinitis, pharyngolaryngitis, tenosynovitis and heel inflammation.

The invention also provides a product comprising any of the above compositions.

The product can also contain one or more auxiliary materials acceptable in the related field besides one or more of any composition of the invention. Of course, other known active ingredients with similar therapeutic functions may also be included.

The invention has the beneficial effects that:

the pharmaceutical composition disclosed by the invention combines the traditional Chinese and western medicine, so that the dosage of western medicines taken by a patient in the treatment process is greatly reduced, the damage of the western medicines to internal organs of the patient such as liver and kidney is reduced, the pharmaceutical composition has an obvious treatment effect and a good treatment effect, and an effective new scheme and a new strategy are provided for the treatment of rheumatism, rheumatoid, gout and various inflammations.

Detailed Description

The following examples are only preferred embodiments of the present invention and are not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

The traditional Chinese medicine components used in the examples: caulis Lonicerae, rhizoma Seu herba Bergeniae, herba Rostellulariae, herba cor pulmonaris, herba Houttuyniae, radix seu folium Gaultheriae Forrestii, radix Ophiopogonis, herba Ainsliaeae Rubrinervis, folium Ilicis Purpureae, pericarpium Citri Tangerinae, and JIANGUFENG, all are dried Chinese medicinal materials.

The western medicine components used in the examples: dexamethasone, chlorpheniramine maleate and Massa Medicata Fermentata are all commercially available drugs.

Example 1 preparation of the composition

Crushing 2g of honeysuckle stem, 3g of bergenia purpurascens, 8g of herba violae, 2g of common rush, 9g of houttuynia cordata, 2g of radix cynanchi atrati, 4g of creeping liriope, 3g of Ainsliaea fragrans, 10g of Chinese ilex leaf, 10g of orange peel and 9g of Jianzhufeng by using a crusher, and repeatedly crushing for three times to obtain mixed traditional Chinese medicine powder; then, 1g of dexamethasone, 1g of chlorphenamine maleate and 5g of medicinal fermented mass are crushed by a crusher to obtain western medicine powder; finally, the traditional Chinese medicine powder and the western medicine powder are uniformly mixed to obtain the composition powder.

Example 2 preparation of the composition

Crushing 8g of honeysuckle stem, 6g of bergenia purpurascens, 3g of herba silenes fortunei, 10g of pneumococcus, 3g of houttuynia cordata, 10g of radix cynanchi atrati, 10g of radix ophiopogonis, 8g of Ainsliaea fragrans, 1g of Chinese ilex leaf, 4g of orange peel and 3g of Jianhuofeng by using a crusher, and repeatedly crushing for three times to obtain mixed traditional Chinese medicine powder; then 10g of dexamethasone, 6g of chlorphenamine maleate and 20g of medicinal fermented mass are crushed by a crusher to obtain western medicine powder; finally, the traditional Chinese medicine powder and the western medicine powder are uniformly mixed to obtain the composition powder.

Example 3 preparation of the composition

Crushing 6g of honeysuckle stem, 5g of bergenia purpurascens, 5g of herba violae, 7g of common rush, 4g of houttuynia cordata, 8g of radix cynanchi atrati, 8g of radix ophiopogonis, 6g of Ainsliaea fragrans, 4g of Chinese ilex leaf, 7g of orange peel and 4g of Jianzhufeng with a crusher, and repeatedly crushing for three times to obtain mixed traditional Chinese medicine powder; then, 2g of dexamethasone, 5g of chlorphenamine maleate and 10g of medicinal fermented mass are crushed by a crusher to obtain western medicine powder; finally, the traditional Chinese medicine powder and the western medicine powder are uniformly mixed to obtain the composition powder.

Example 4 preparation of the composition

Crushing 5g of honeysuckle stem, 4g of bergenia purpurascens, 6g of herba violae, 8g of common rush, 5g of houttuynia cordata, 5g of radix cynanchi atrati, 5g of creeping liriope, 5g of Ainsliaea fragrans champ, 7g of Chinese ilex leaf, 9g of orange peel and 5g of Jianzhufeng with a crusher, and repeatedly crushing for three times to obtain mixed traditional Chinese medicine powder; then 5g of dexamethasone, 3g of chlorphenamine maleate and 15g of medicinal fermented mass are crushed by a crusher to obtain western medicine powder; finally, the traditional Chinese medicine powder and the western medicine powder are uniformly mixed to obtain the composition powder.

Example 5 preparation of the composition

Crushing 8g of honeysuckle stem, 5g of bergenia purpurascens, 6g of herba violae, 8g of common rush, 5g of houttuynia cordata, 5g of radix cynanchi atrati, 5g of creeping liriope, 5g of Ainsliaea fragrans champ, 7g of Chinese ilex leaf, 10g of orange peel and 5g of Jianzhufeng by a crusher, and repeatedly crushing for three times to obtain mixed traditional Chinese medicine powder; then 5g of dexamethasone, 3g of chlorphenamine maleate and 15g of medicinal fermented mass are crushed by a crusher to obtain western medicine powder; finally, the traditional Chinese medicine powder and the western medicine powder are uniformly mixed to obtain the composition powder.

Example 6 preparation of the composition

Crushing 6g of honeysuckle stem, 5g of bergenia purpurascens, 5g of herba violae, 7g of herba cor pulmonale, 4g of herba houttuyniae, 8g of radix cynanchi atrati, 5g of radix ophiopogonis, 6g of herba leprae, 10g of folium ilicis chinensis, 5g of orange peel and 4g of jiangfeng by using a crusher, and repeatedly crushing for four times to obtain mixed traditional Chinese medicine powder; then, 2g of dexamethasone, 5g of chlorphenamine maleate and 10g of medicinal fermented mass are crushed by a crusher to obtain western medicine powder; finally, the traditional Chinese medicine powder and the western medicine powder are uniformly mixed to obtain the composition powder.

Example 7 preparation of the composition

The drugs taken by the patients in the following examples are all the composition powders prepared in example 3.

Example 8

Patients who are male and 45 years old and merchants visit 2016 and 7 months, the patients have gout for about three years, the disease condition is not improved after visiting the patients in a plurality of hospitals, the powder disclosed by the invention is taken for one week to relieve symptoms (twice a day, once in the morning and at night, and 2.25g is taken every time), the pain is relieved, the gout is cured after the powder is taken for one month, and the gout symptoms are completely disappeared for more than three years and do not relapse.

Example 9

The patient Li a, man, 23 years old, peasant, come to the clinic before 2017 month 3, have had rhinitis for more than four years since self-statement, smell pollen, dust at ordinary times, or when season changes, sneeze, snivel cearound constantly, and relapse frequently, so he examines and treats in many hospitals, takes medicine for a long time and does not take effect either, take the powder of the invention for about ten days, the symptom is reduced a lot (twice a day, once in the morning and evening, each time take 2.25g), continue taking for about 20 days later, the symptom is completely eliminated, and relapse is few at present.

Example 10

The patient is old and young, and is a woman in 50 years old, and farmers have come to see a diagnosis before 2016 and 5 months, have self-reported pharyngolaryngitis for 5 to 6 years, have been seen in multiple hospitals, have spent tens of thousands of yuan before and after checking and taking medicines, but have no obvious effect, and even if the patient does not catch a cold, the patient still often coughs and cough and asthma in daily life. If the symptoms are aggravated and severe cough is caused by cold, after the composition powder is taken for one month (twice a day, once in the morning and at night, and 2.25g of the composition powder is taken each time), the symptoms are obviously improved, the composition powder is continuously taken, and the cough is cured after the composition powder is taken for about three months, so that the cough symptoms do not exist at present.

Example 11

Patients who swim to a certain place, male and 46 years old, teachers see a diagnosis before 2017 and 8 months, the patients have 2 years of self-describing otitis media, frequent earache, tinnitus and purulent secretion in ears, and the treatment effect in hospitals is poor.

Example 12

Patients who are Wu-Chi, women, age 39 and workers have a diagnosis before 2017 in 6 months, have been self-reported for 2 years on their tenosynovitis, have inflexible joint movement and swollen joints, and have poor treatment effect in various hospitals, and after taking the composition powder for one month (twice a day, once in the morning and at night, 2.25g each time), the symptoms are obviously improved, the medicine is continuously taken for about three months, the disease is cured, the joints can flexibly move, and normal life work is recovered.

Example 13

The patient is in a certain position, women are in the age of 52 years, and the patient is in a diagnosis before 2016 and 6 months, the patient has 3 years of self-describing rheumatoid disease, morning stiffness symptoms are still often seen in the morning, the finger joints have partial deformity, the treatment effect is poor through western medicine treatment in hospitals, after the composition powder is taken for one month (twice a day, once in the morning and once in the evening, and 2.25g is taken each time), the morning stiffness symptoms are obviously improved, the morning stiffness symptoms disappear after the medicine is continuously taken for about half a year, the deformity of the finger joints is not worsened, and the joints can move flexibly.

Example 14

Patients are Zhang for a certain time, women are 45 years old and have no business, the patients are diagnosed 2 months before 2017, the self rheumatic arthritis is described for 5 years, the general arthralgia often accompanies the arthralgia occasionally, the curative effect is not good through western medicine treatment in hospitals, the powder of the composition is taken for one month (twice a day, once in the morning and at night, 2.25g is taken each time), the symptoms are obviously improved, the medicine is continuously taken for about half a year, the symptoms of the arthralgia and the myalgia disappear, and the recurrence is not seen until now.

The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes, which are made by the present specification, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.

Claims

1. The composition is characterized by comprising the following components in parts by weight: 2-8 parts of honeysuckle stem, 3-6 parts of bergenia purpurascens, 3-8 parts of herba silenes fortunei, 2-10 parts of pneumococcus, 3-9 parts of houttuynia cordata, 2-10 parts of radix cynanchi atrati, 4-10 parts of creeping liriope, 3-8 parts of Ainsliaea fragrans, 1-10 parts of ilex leaf, 4-10 parts of orange peel, 3-9 parts of Jianzhuifeng, 1-10 parts of dexamethasone, 1-6 parts of chlorphenamine maleate and 5-20 parts of Jianqu.

2. The composition of claim 1, wherein all components are present in dry amounts.

3. The composition according to claim 1, characterized by comprising the following components in parts by weight: 6 parts of honeysuckle stem, 5 parts of bergenia purpurascens, 5 parts of herba sileris, 7 parts of pneumococcus, 4 parts of houttuynia cordata, 8 parts of radix cynanchi atrati, 8 parts of radix ophiopogonis, 6 parts of Ainsliaea fragrans, 4 parts of Chinese ilex leaf, 7 parts of orange peel, 4 parts of Jianhufeng, 2 parts of dexamethasone, 5 parts of chlorphenamine maleate and 10 parts of medicinal fermented mass.

4. A method of preparing a composition as claimed in any one of claims 1 to 3, comprising: mixing caulis Lonicerae, rhizoma Seu herba Bergeniae, herba Rostellulariae, herba cor pulmonaris, herba Houttuyniae, radix seu folium Gaultheriae Forrestii, radix Ophiopogonis, herba Ainsliaeae Rubrinervis, folium Ilicis Purpureae, pericarpium Citri Tangerinae, JIANZHENGFENG, dexamethasone, chlorphenamine maleate, and Massa Medicata Fermentata.

5. A powder comprising the composition of any one of claims 1 to 3.

6. A method of preparing a powder formulation as claimed in claim 5, which comprises: (1) according to the weight parts, honeysuckle stem, bergenia, herba violae, cor pulmonale, houttuynia cordata, radix cynanchi wilfordii, creeping liriope, leprianum glaucescens, Chinese ilex leaf, orange peel, jiangzhuifeng, dexamethasone, chlorphenamine maleate and medicated leaven are taken; (2) pulverizing the components of the composition; (3) the components of the composition are mixed.

7. Use of the composition of any one of claims 1 to 3 for the preparation of a product having a dehumidifying and anti-inflammatory effect.

8. The use according to claim 7, wherein the product is a product for preventing and/or treating one or more of rheumatism, rheumatoid, gout and inflammatory diseases.

9. The use according to claim 8, wherein the inflammation is selected from one or more of otitis media, rhinitis, pharyngolaryngitis, tenosynovitis, and heel inflammation.

10. A product comprising the composition of any one of claims 1 to 3.