CN106822714A - A kind of gynaecological gel and preparation method thereof - Google Patents
A kind of gynaecological gel and preparation method thereof Download PDFInfo
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- CN106822714A CN106822714A CN201710173141.7A CN201710173141A CN106822714A CN 106822714 A CN106822714 A CN 106822714A CN 201710173141 A CN201710173141 A CN 201710173141A CN 106822714 A CN106822714 A CN 106822714A
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- gynaecological
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The invention discloses a kind of gynaecological gel and preparation method thereof, often included in the 40g gynaecological gels：The 40g of frutus cnidii 20, the 40g of the fruit of summer cypress 20, the 40g of kuh-seng 20, the 20g of golden cypress 10, the 30g of smilax 10, the 20g of pericarpium zanthoxyli 10.Without any additive, prescription used is respectively provided with the characteristics of raw material sources are extensive, moderate, production technology is easy to this product, uses nontoxic Chinese medicine by primary raw material is made, nontoxic non-stimulated, evident in efficacy, Small side effects；There are obvious anti-inflammatory, analgesic and itching-relieving action, and have no obvious adverse reaction, overall efficiency and cure rate are higher, be the promising gynaecological gel of comparing；And prescription compatibility of medicines is rationally, can keep the acid-base balance of vagina.
Description
Technical field
The present invention relates to field of traditional Chinese, and in particular to a kind of gynaecological gel and preparation method thereof.
Background technology
Gynaecological imflammation is the common clinical in gynecological disease, typically caused by courses of infection.Such state of an illness is more long, the state of an illness
Recurrent exerbation, the state of an illness is more obstinate, has a strong impact on the physical and mental health and live and work of women.At present, gynaecological imflammation is treated
Medicament categories are various, are broadly divided into suppository class, lotion class, spray class and effervescent tablet class etc..There is the yellow Pu clean skin lotion of pure Chinese medicine,
Bactericidal action is safe and non-stimulating from plurality of active ingredients such as golden cypress, the coptis and dandelions, and yellow Pu clean skin lotion is weak acid
Property lotion, can maintain the environmental balance of vagina itself, improve the immunity of body.Also Chinese medicine and chemical composition combine
, such as：Clean your the moon, FUYINJIE, FUKE QIANJIN PIAN etc., are taken stopgap measures using the sterilization of chemical composition, are effected a permanent cure using traditional Chinese medicine ingredients, are
A kind of method treated both principal and secondary aspect of disease.
If the prescription compatibility of medicines of medicine (particularly externally applied drug) is unreasonable, vagina acid-base balance can be destroyed.Therefore, seek new
More rational compatibility, improve treatment gynaecological imflammation curative effect, be to need to continue deeper into the emphasis of research and direction.
The content of the invention
To solve the above problems, the invention provides a kind of gynaecological gel and preparation method thereof, gynaecology can be effectively treated
Inflammation.
To achieve the above object, the technical scheme taken of the present invention is：
A kind of gynaecological gel, includes in every 40g gels：Frutus cnidii 20-40g, fruit of summer cypress 20-40g, kuh-seng 20-
40g, golden cypress 10-20g, smilax 10-30g, pericarpium zanthoxyli 10-20g.
Preferably, included in every 40g：Frutus cnidii 30g, fruit of summer cypress 30g, kuh-seng 30g, golden cypress 15g, smilax 20g, pericarpium zanthoxyli
15g。
Present invention also offers a kind of above-mentioned preparation method of gynaecological gel, comprise the following steps：
S1, weigh each component by above-mentioned formula；
Medicinal distillation in S2, the frutus cnidii that will be weighed, the fruit of summer cypress, kuh-seng 30, golden cypress 15, smilax 20, the Six-element of pericarpium zanthoxyli 15
Fried after water immersion 30min, liquid medicine ratio is medicinal water 100ml in 30g, is made 1.5g/ml crude drugs, is eventually fabricated gel.
This product is without any additive, and it is extensive, moderate, production technology simplicity that prescription used is respectively provided with raw material sources
Feature, while the present invention has further the advantage that：
1. the present invention uses nontoxic Chinese medicine by primary raw material is made, nontoxic non-stimulated, evident in efficacy, Small side effects.
2. the present invention has obvious anti-inflammatory, antalgesic-antipruritic to act on, and has no obvious adverse reaction, overall efficiency and cure rate
Bacterium is higher, is the promising gynaecological gel of comparing.
3. prescription compatibility of medicines of the invention rationally, can keep the acid-base balance of vagina.
Brief description of the drawings
Fig. 1 is a kind of flow chart of the preparation method of gynaecological gel of the embodiment of the present invention.
Specific embodiment
In order that objects and advantages of the present invention become more apparent, the present invention is carried out further with reference to embodiments
Describe in detail.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to limit this hair
It is bright.
As shown in figure 1, the embodiment of the invention provides a kind of preparation method of gynaecological gel, comprise the following steps：
S1. the bulk drug of following weight is weighed：Frutus cnidii 30g, fruit of summer cypress 30g, kuh-seng 30g, golden cypress 15g, smilax
20g, pericarpium zanthoxyli 15g.
S2. by above-mentioned raw materials frutus cnidii 30g, fruit of summer cypress 30g, kuh-seng 30g, golden cypress 15g, smilax 20g, pericarpium zanthoxyli 15g
Medicinal material drying, fine powder is ground into, sieved for subsequent use；
S3.. 467ml distilled water, immersion 30min to the saturating heart are added in the fine powder of step 2；30min is decocted, liquid is obtained
Regulation PH, filtering.It is eventually fabricated gel.
Embodiment 1
1. the bacteriostatic test and data of inventive gel agent：
2. inventive gel agent is carried out 2,5,10,20 minutes to staphylococcus aureus, Escherichia coli, Candida albicans
Effect, as a result such as table 1 below：
Table 1
Negative control：Culture medium has little bacterium colony.
Result shows, use the present invention be average bacteriostasis rate to staphylococcus aureus, Escherichia coli, Candida albicans for
90%.
Embodiment 2
Acute oral toxicity test
Acute oral toxicity LD of the present invention to male and female mouse50＞ 5000mg/kg BW, belong to actual nontoxic level.
Embodiment 3
Vaginal mucosa irritation is tested：
Test method：Set up low dosage administration group, high dose administration group, model group and blank control group.Every group 10
Be applied to gel in SD rat vaginas by adult healthy female rats, low dosage administration group, high dose administration group, model group with
Sliver leaching sterile saline is placed in tested SD rats, and 24h is contacted with animal vaginal mucosa, and blank control group does not give then
Any treatment, puts to death animal after 24h, take out whole vagina, observes the hyperemia of topical vaginal tissue, and oedema reacting phenomenon is carried out
IR is evaluated.
Result of the test：Locally guiding tissue does not find that hyperemia, oedema etc. are abnormal to administration group with blank control group SD rats
Reaction, does not find other symptoms, vaginal mucosa SI+0.0 yet.
Result shows that vaginal mucosa stimulation of the inventive gel agent to female sd inbred rats belongs to non-stimulated.
Embodiment 4
The human clinical data of inventive gel agent：
Case selection：Patient 375, wherein age 18-55 Sui, bacterial vaginitis 97；Colpomycosis 100
Example；Trichomonas vaginitis 89.
Cardinal symptom：Leucorrhea increasing, pruritus vulvue, pain be able to can regard sb. as an outsider with frequent micturition, odynuria or intercourse pain during inspection
Cloudy and vaginal mucosa goes out hyperemia.Visible trichomonad or true is distinguished during trichomonas or colpomycosis patient's vaginal fluid microscopy
Bacterium, bacterium row vaginitis BV checks positive.
The specific application method of inventive gel agent：Use 2 times daily, each 5g is applied directly to vagina.
Control group uses clean that the moon, FUYINJIE, application method：Daily 2 times, each 10ml uses vagina cleaner.
Outcome measure：
Recovery from illness：Subjective symptoms is disappeared, and vagina cleanness degree (I), vaginal swab culture is turned out cloudy；
Effectively：Subjective symptoms mitigates, and vagina cleanness degree (II), vaginal swab culture only has a small number of bacterial growths, at most not
More than 10.
It is invalid：Feel normally without improvement, vagina cleanness degree is unchanged, and vaginal swab culture is unchanged.Curative effect is shown in Table 2
Table 2
In sum, gynaecological gel of the present invention has good curative effect on treatment gynecological disease, and the gel can be quick
Suppress and kill the pathogenic bacteria such as staphylococcus aureus, Pseudomonas aeruginosa, mycin.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (3)
1. a kind of gynaecological gel, it is characterised in that included in per 40g gels：Frutus cnidii 20-40g, fruit of summer cypress 20-40g,
Kuh-seng 20-40g, golden cypress 10-20g, smilax 10-30g, pericarpium zanthoxyli 10-20g.
2. a kind of gynaecological gel as claimed in claim 1, it is characterised in that included in per 40g：Frutus cnidii 30g, the fruit of summer cypress
30g, kuh-seng 30g, golden cypress 15g, smilax 20g, pericarpium zanthoxyli 15g.
3. the preparation method of a kind of gynaecological gel as described in claim any one of 1-2, it is characterised in that including following step
Suddenly：
S1, the formula as described in claim any one of 1-2 weigh each component；
Medicinal distilled water leaching in S2, the frutus cnidii that will be weighed, the fruit of summer cypress, kuh-seng 30, golden cypress 15, smilax 20, the Six-element of pericarpium zanthoxyli 15
Fried after bubble 30min, liquid medicine ratio is medicinal water 100ml in 30g, is made 1.5g/ml crude drugs, is eventually fabricated gel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710173141.7A CN106822714A (en) | 2017-03-22 | 2017-03-22 | A kind of gynaecological gel and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710173141.7A CN106822714A (en) | 2017-03-22 | 2017-03-22 | A kind of gynaecological gel and preparation method thereof |
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| Publication Number | Publication Date |
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| CN106822714A true CN106822714A (en) | 2017-06-13 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710173141.7A Pending CN106822714A (en) | 2017-03-22 | 2017-03-22 | A kind of gynaecological gel and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113117045A (en) * | 2021-06-04 | 2021-07-16 | 武汉前程生物科技有限公司 | Traditional Chinese medicine preparation for white hair and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102988844A (en) * | 2012-12-28 | 2013-03-27 | 常福厚 | Gynaecological gel and extraction method thereof |
| WO2014059880A1 (en) * | 2012-10-18 | 2014-04-24 | 中国科学院新疆理化技术研究所 | Method for preparation of pomegranate-peel polyphenol gel used to treat gynecological inflammation |
-
2017
- 2017-03-22 CN CN201710173141.7A patent/CN106822714A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014059880A1 (en) * | 2012-10-18 | 2014-04-24 | 中国科学院新疆理化技术研究所 | Method for preparation of pomegranate-peel polyphenol gel used to treat gynecological inflammation |
| CN102988844A (en) * | 2012-12-28 | 2013-03-27 | 常福厚 | Gynaecological gel and extraction method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113117045A (en) * | 2021-06-04 | 2021-07-16 | 武汉前程生物科技有限公司 | Traditional Chinese medicine preparation for white hair and preparation method thereof |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
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| RJ01 | Rejection of invention patent application after publication | ||
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Application publication date: 20170613 |