CN107467037A - A kind of pharmaceutical composition for preventing and treating wheat scab - Google Patents
A kind of pharmaceutical composition for preventing and treating wheat scab Download PDFInfo
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- CN107467037A CN107467037A CN201710906909.7A CN201710906909A CN107467037A CN 107467037 A CN107467037 A CN 107467037A CN 201710906909 A CN201710906909 A CN 201710906909A CN 107467037 A CN107467037 A CN 107467037A
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- Prior art keywords
- pharmaceutical composition
- wheat scab
- preventing
- metconazole
- treating wheat
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
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- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Dispersion Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
In order to more effectively prevent and treat the germ of wheat scab, the present invention proposes is combined compounding by pesticide active ingredient, and wheat diseases are prevented and treated.The present invention is notable by synergistic effect after metconazole, Tebuconazole both active ingredient mixtures, improve bactericidal activity, greatly reduce dosage, and it is horizontal to the resistance risk of chemical agent to be more importantly reduction of pathogen, be advantageous to delay pathogen the resistance to the action of a drug occur to active ingredient in formula, reduce disease simultaneously to endanger to caused by production estimation, be advantageous to improve the quality and quality of agricultural product.
Description
Technical field
The invention belongs to pesticide field, and in particular to a kind of pharmaceutical composition for preventing and treating wheat scab.
Background technology
Wheat scab generally occurs in the whole world, is distributed mainly on moist and half tide wet zone, and especially weather moistening is more
The Temperate Region in China of rain is aggrieved serious, and In Middle And Lower Reaches of Changjiang River and south China Winter Wheat Area and Northeasten Spring Wheat Area of China are concentrated mainly in China.
All can be aggrieved to heading from seedling, mainly cause withered seedling, stem rot, stalk corruption and fringe rotten.Cause the pathogen master of wheat scab
There are F.graminearum schw, yellow fusarium, oat fusarium, oat fusarium, pears spore fusarium and the rotten fusarium of snow.
Medicament prevention and control at present are still to control the main method of wheat scab.Prevent and treat the pesticidal preparations kind of wheat scab
Class is various, such as single dose has carbendazim, thiophanate-methyl, Tebuconazole etc..Metconazole belongs to triazole bactericidal agent, its mechanism of action
Be ergosterol biosynthesis in C-14 demethylation enzyme inhibitors, suitable for crop includes wheat, barley, oat, rye, small
Rye etc., is mainly used in preventing and treating wheat septoria bacterium, fringe sickle-like bacteria, leaf rust, stripe rust, powdery mildew, the short shape rust of barley, white
Powder disease, crown hull sugar, triticale leaf rust etc., have protection and therapeutic action.But the medicaments such as Tebuconazole, carbendazim, because
Long-term use, the more serious resistance to the action of a drug is generated in field, so as to reduce its drug effect value.Meanwhile metconazole is in China
There has been no correlation at present to register.
The content of the invention
In order to more effectively prevent and treat the germ of wheat scab, present inventor proposes to carry out pesticide active ingredient
Wheat diseases are prevented and treated by combination compounding.Unexpectedly, inventor is had found by test of many times, by metconazole, Tebuconazole this two
Synergistic effect is notable after kind active ingredient mixture, improves bactericidal activity, greatly reduces dosage, and more importantly drop
Low pathogen is horizontal to the resistance risk of chemical agent, is advantageous to delay pathogen anti-medicine occur to active ingredient in formula
Property, while reduce disease and endangered to caused by production estimation, be advantageous to improve the quality and quality of agricultural product.
Therefore, the first object of the present invention is to provide a kind of pharmaceutical composition for preventing and treating wheat scab, including following
Component:Metconazole and Tebuconazole.
Preferably, in the pharmaceutical composition of preventing and treating wheat scab of the present invention, the metconazole and Tebuconazole
Ratio be:10:1-1:10 (weight ratios).
Preferably, in the pharmaceutical composition of preventing and treating wheat scab of the present invention, described pharmaceutical composition is outstanding
Floating agent.
Preferably, in the pharmaceutical composition of preventing and treating wheat scab of the present invention, described pharmaceutical composition is also wrapped
Include wetting dispersing agent, stabilizer, antifreezing agent, preservative, He Shui;It is highly preferred that the wetting dispersing agent, antifreezing agent, thickener,
The weight of defoamer and water ratio is 5.5%:3%:0.08%:0.5%:Water is supplied to 100%;Most preferably, the wetting point
Powder, antifreezing agent, thickener and defoamer are respectively alkylnaphthalene sulfonate condensation polymer, ethylene glycol, xanthans and organic silicone.
Present invention also offers application of the aforementioned pharmaceutical compositions in wheat scab is prevented and treated.
Preferably, administrated method of the pharmaceutical composition of the present invention in the preventing and treating wheat scab is to be raised in wheat
Spend the 1st medication at initial stage, interval the 2nd medication after 7 days.
It is highly preferred that the dosage of pharmaceutical composition of the present invention is every mu of dosage 30-50g pharmaceutical composition.
Compared with prior art, the present invention at least has advantages below to the present invention:
1) after metconazole, Tebuconazole being carried out to the present inventor's creativeness into rational proportion, there is obvious increase
Effect acts on, and while bactericidal action is improved, also reduces tolerance of the wheat scab germ to medicament, particularly significantly
Reduce the resistance to the action of a drug of the pathogen to active principle in pharmaceutical composition;
2) pharmaceutical composition of the invention is because reduce medicine usage amount, while yield and quality of wheat is improved,
Reduce residues of pesticides, reduce the side effect that agricultural chemicals is excessively used to agricultural ecological, be environment-friendly type novelty agricultural chemicals.
3) pharmaceutical composition has a broad antifungal spectrum of the invention, to have potential various crop disease environment-protection pesticide.
Embodiment
Below in conjunction with the embodiment in the present invention, the technical scheme in the present invention is clearly and completely described.It is aobvious
So, described embodiment is only part of the embodiment of the present invention, rather than whole embodiments.Based on the reality in the present invention
Example is applied, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made, is all belonged to
In the scope of protection of the invention.
The weight metconazole tebuconazole suspension concentrates of embodiment 1 40%
(1) raw material:Weighed exemplified by producing 1000kg
Metconazole 200kg, Tebuconazole 200kg, wetting dispersing agent, antifreezing agent, thickener, defoamer, surplus are water.
(2) preparation method:The above-mentioned each raw material weighed is added in blender, by being sufficiently mixed, being sanded, detecting, mistake
Filter, detection, last subpackage dress.
Embodiment 2:48% weight metconazole tebuconazole suspension concentrates
(1) raw material:Weighed exemplified by producing 1000kg
Metconazole 240kg, Tebuconazole 240kg, wetting dispersing agent alkylnaphthalene sulfonate condensation polymer, antifreeze glycol, increasing
Thick dose of xanthans, defoamer organic silicone, surplus are water (wetting dispersing agent, antifreezing agent, thickener, the weight of defoamer and water
Ratio is 5.5%:3%:0.08%:0.5%:Water is supplied to 100%).
(2) preparation method:The above-mentioned each raw material weighed is added in blender, by being sufficiently mixed, being sanded, detecting, mistake
Filter, detection, last subpackage dress.
Embodiment 3:The acute dermal toxicity experiment of 40% metconazole tebuconazole suspension concentrates
Using SD rats as experimental animal, the urgency of 40% metconazole tebuconazole suspension concentrates (embodiment 1 prepares) is carried out
Property percutaneous toxicity test.Experiment is according to National Standard of the People's Republic of China GB15670-1995《Agriculture chemical registration toxicology test
Method》Acute dermal toxicity test method, by pilot study result, using maximum dose method, test dose 2000mg/kg,
Totally 10 animals, male and female half and half.Continuous observation 14 days after contamination, record animal poisoning symptom and death time.As a result it is as follows:
Median lethal dose (LD50) and 95% credibility interval
Female rats:More than 2000mg/kg.b.wt.;Male rat:More than 2000mg/kg.b.wt.
Conclusion:According to acute toxicity evaluation criterion in above-mentioned national standard and above result of the test, 40% metconazole penta
Azoles alcohol suspending agent rat acute percutaneous toxicity belongs to " low toxicity ".
Embodiment 4:The acute oral toxicity test of 40% weight metconazole tebuconazole suspension concentrates
Using SD rats as experimental animal, the acute warp of 40% metconazole tebuconazole suspension concentrates (prepared by embodiment 1) is carried out
Mouth toxicity test.Experiment is according to National Standard of the People's Republic of China GB15670-1995《Agriculture chemical registration toxicology test method》
Acute oral toxicity test method, by pilot study result, design dosage.Experiment sets 1000,1780,3160,5600mg/kg tetra-
Individual dosage group, every group 10, totally 40 animals, male and female half and half.Continuous observation 14 days after contamination, record animal poisoning symptom and dead
Die the time.As a result it is as follows:
Median lethal dose (LD50):
Female/male rat:3160mg/kg.b.wt.
Conclusion:According to acute toxicity evaluation criterion in above-mentioned national standard and above result of the test, 40% weight leaf bacterium
Azoles tebuconazole suspension concentrates rat acute toxicity belongs to " low toxicity ".
Embodiment 5:40% metconazole tebuconazole suspension concentrates prevent and treat wheat scab field control effectiveness test
1 trial crops
(kind is peaceful wheat 14 to wheat, tests and collects in Lianshui County Xiao Li, and soil types is sandy loam, quality of organic matter fraction
For 2.2%, pH value 7.5, soil fertility is medium).
2 controlling objects
Wheat scab
3 experimental designs are with arranging
3.1 medicament
3.1.1 test medicine:40% metconazole tebuconazole suspension concentrates (prepared by embodiment 1);
3.1.2 comparison medicament:430g/L tebuconazole suspension concentrates (are purchased from Yancheng Limin Chemical Co., Ltd. of Jiangsu Province), and 6%
Metconazole aqua (is purchased from BASF AG)
3.1.3 dosing and numbering
The reagent agent experimental design of table 1
Processing numbering | Medicament | Dispenser dosage (amount of formulation) | Formulation rate (active ingredient amount) |
1 | 40% metconazole tebuconazole suspension concentrates | 30g/ mus | 180g/ hectares |
2 | 40% metconazole tebuconazole suspension concentrates | 40g/ mus | 240g/ hectares |
3 | 40% metconazole tebuconazole suspension concentrates | 60g/ mus | 360g/ hectares |
4 | 430g/L tebuconazole suspension concentrates | 50mL/ mus | 322.5g/ hectare |
5 | 6% metconazole aqua | 100g/ mus | 90g/ hectares |
6 | CK | Equivalent clear water | Equivalent clear water |
3.2 cell arrangements
3.2.1 cell arranges
The cell permutation table of table 2
Numbering | District's groups 1 | District's groups 2 | District's groups 3 | District's groups 1 |
1 | Processing 6 | Processing 4 | Processing 2 | Processing 1 |
2 | Processing 2 | Processing 3 | Processing 4 | Processing 6 |
3 | Processing 1 | Processing 2 | Processing 5 | Processing 3 |
4 | Processing 4 | Processing 5 | Processing 3 | Processing 2 |
5 | Processing 5 | Processing 6 | Processing 1 | Processing 4 |
6 | Processing 3 | Processing 1 | Processing 6 | Processing 5 |
3.2.2 plot area and repetition
Plot area:Per 30 square metres of plot area;
Number of repetition:4 repetitions.
3.3 application method
Using spray method:In wheat flowering the 1st medication at initial stage, interval the 2nd medication after 7 days, every mu of water consumption
60kg, CK spray equivalent clear water.
4 adjust difference method, time and number
4.2.1 control time and number
Disease investigation is carried out in wheat milk stage.Often processing investigates at 5 points, and every 100 fringes, 500 fringe, investigates each processing altogether
Sick spike number and severity, calculate disease tassel yield, disease index and disease tassel yield and disease refers to and preventive effect.
Head blight Severity gradation method:
0 grade:Full fringe is disease-free;
1 grade:Withered fringe area accounts for less than the 1/4 of full fringe area;
2 grades:Withered fringe area accounts for the 1/4-1/2 of full fringe area;
3 grades:Withered fringe area accounts for the 1/2-3/4 of full fringe area;
4 grades:Withered fringe area accounts for more than the 3/4 of full fringe area.
4.2.3 control time and number
Disease tassel yield is calculated by formula (1):
D=Nd/N×100…………………………………………………(1)
In formula:
D-disease tassel yield, unit are percentage (%);
Nd- sick spike number;
The total spike number of N-investigation.
Disease index is calculated by formula (2), and result of calculation retains 2 significant digits;
In formula:
X-disease index;
Ni-sick spike number at different levels;
I-relative value of series;
The total spike number of N-investigation.
Prevention effect is calculated by formula (3):
P=(X1-X2)/X1×100………………………………………………(3)
In formula:
P-prevention effect, unit are percentage (%);
X1- blank district disease index;
X2- chemicals treatment district disease index.
4.2.4 crop is directly affected
Observation medicament whether there is poisoning to crop, if any poisoning, records the type and extent of poisoning.
5 results and analysis
The metconazole tebuconazole suspension concentrates of table 3 40% prevent and treat wheat scab result of the test
*:A ab c represent the significance of difference respectively handled under 95% confidence limit
5.1 biological statistical method:Notable difference test uses " DMRT " method;
5.2 result of the test
Result of the test shows that each processing has certain preventive effect to wheat scab, and from the point of view of final investigation result, disease refers to
The processing of preventive effect from high to low is followed successively by:40% metconazole tebuconazole suspension concentrates 60g/ mus, 40% metconazole Tebuconazole hang
Floating agent 40g/ mus, 430g/L tebuconazole suspension concentrates 50mL/ mus, 6% metconazole aqua 100g/ mus, 40% metconazole Tebuconazole
Suspending agent 30g/ mus, preventive effect are respectively 89.44%, 84.12%, 80.70%, 79.15%, 68.68%;Come from the significance of difference
Analysis, 40% metconazole tebuconazole suspension concentrates 60g/ mus, 40% metconazole tebuconazole suspension concentrates 40g/ mus and other are several
Between treatment group, it is more significant that disease refers to preventive effect difference.
5.3 interpretation of result
Can be seen that from result of the test, 40% metconazole tebuconazole suspension concentrates preventing and treating wheat scab has preferable preventive effect,
And to wheat safety, while wheat scab can be delayed formulation environmental protection, to be applied to metconazole and the resistance development of Tebuconazole
Industrialized production.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of pharmaceutical composition for preventing and treating wheat scab, including following components:Metconazole and Tebuconazole.
2. the pharmaceutical composition of preventing and treating wheat scab according to claim 1, it is characterised in that the metconazole and penta
The ratio of azoles alcohol is:10:1-1:10 (weight ratios).
3. the pharmaceutical composition of preventing and treating wheat scab according to claim 1, it is characterised in that described pharmaceutical composition
For suspending agent.
4. the pharmaceutical composition of the preventing and treating wheat scab according to claims 1 to 3 any one, it is characterised in that institute
Stating pharmaceutical composition also includes wetting dispersing agent, antifreezing agent, thickener, defoamer and water.
5. the pharmaceutical composition of preventing and treating wheat scab according to claim 4, it is characterised in that the wetting and dispersing
Agent, antifreezing agent, thickener, the part by weight of defoamer and water are 5.5%:3%:0.08%:0.5%:Water is supplied to 100%.
6. the pharmaceutical composition of preventing and treating wheat scab according to claim 4, it is characterised in that the wetting and dispersing
Agent, antifreezing agent, thickener and defoamer are respectively alkylnaphthalene sulfonate condensation polymer, ethylene glycol, xanthans and organic silicone.
A kind of 7. application of pharmaceutical composition according to claim 1~6 any one in corps diseases are prevented and treated.
8. a kind of pharmaceutical composition according to claim 1~6 any one is applied in wheat scab is prevented and treated.
9. purposes according to claim 7, it is characterised in that the administrated method of the preventing and treating wheat scab is in wheat
Flowering the 1st medication at initial stage, interval the 2nd medication after 7 days.
10. purposes according to claim 7, it is characterised in that the dosage of described pharmaceutical composition is every mu of dosage 30-
50g pharmaceutical compositions.
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CN201710906909.7A CN107467037A (en) | 2017-09-29 | 2017-09-29 | A kind of pharmaceutical composition for preventing and treating wheat scab |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN111202076A (en) * | 2018-11-22 | 2020-05-29 | 江苏龙灯化学有限公司 | Bactericidal composition |
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CN106172421A (en) * | 2016-07-05 | 2016-12-07 | 南京农业大学 | A kind of containing metconazole and the bactericidal composition of Tebuconazole and application |
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CN106172421A (en) * | 2016-07-05 | 2016-12-07 | 南京农业大学 | A kind of containing metconazole and the bactericidal composition of Tebuconazole and application |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN111202076A (en) * | 2018-11-22 | 2020-05-29 | 江苏龙灯化学有限公司 | Bactericidal composition |
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Application publication date: 20171215 |