CN102239862A - Compound bactericide of azoxystrobin and polyoxin - Google Patents
Compound bactericide of azoxystrobin and polyoxin Download PDFInfo
- Publication number
- CN102239862A CN102239862A CN2011101398811A CN201110139881A CN102239862A CN 102239862 A CN102239862 A CN 102239862A CN 2011101398811 A CN2011101398811 A CN 2011101398811A CN 201110139881 A CN201110139881 A CN 201110139881A CN 102239862 A CN102239862 A CN 102239862A
- Authority
- CN
- China
- Prior art keywords
- polyoxin
- fluoxastrobin
- azoxystrobin
- bactericide
- cost
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to the technical field of pesticides, and relates to a compound bactericide of azoxystrobin and polyoxin. The active components of the bactericide comprise azoxystrobin and polyoxin, and the weight ratio of the azoxystrobin to the polyoxin in the components is (20:1)-(1:20), preferred (10:1)-(1:10). The invention has the beneficial effects that: because the azoxystrobin is a methoxyl acrylic compound and the polyoxin is a novel agricultural antibiotic, the azoxystrobin and the polyoxin have different mechanisms of action, different action sites and no cross resistance, and pathogenic bacteria are not liable to generate resistance by mutually compounding the azoxystrobin with the polyoxin; and the pesticide consumption and use cost are reduced due to synergy. The cost is higher when the azoxystrobin is singly used, while the cost is obviously reduced by compounding the azoxystrobin with the polyoxin on the premise that the pesticide effect is ensured.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of Fluoxastrobin and polyoxin composite bactericide.
Background technology
Fluoxastrobin (Azoxystrobin) be a kind of be lead compound with the natural antibiotics that comes from mushroom, by the synthetic a kind of brand-new disease management product of artificial bionic.It belongs to methoxy acrylic acid lipid bactericide, and efficient, wide spectrum, tool are protected, treat, root out, permeated, interior suction multi-efficiency.Fluoxastrobin infects spore germination and mycelia by the breathing production capacity process that suppresses pathogen and is suppressed, thereby causes pathogen loss of life power.Fluoxastrobin has good crop safety and very outstanding Environmental compatibility.
At present, the azoxystrobin formulations product mainly contains 25% Amici and reaches suspension emulsion, 325 grams per liter phenylate Fluoxastrobin suspending agents, 500 grams per liter Fluoxastrobin tpn suspending agents etc., is mainly used in control vegetables fruit diseases.The independent application of Fluoxastrobin makes germ produce serious resistance easily, is undertaken compositely by different cultivars, is the effective way of preventing and treating the pesticide resistance germ.Composite dose of present Fluoxastrobin is of less types, can not satisfy and produce the needs of going up control of crop disease.
Polyoxin claims Polyoxin again, and nineteen sixty-five is found the earliest by Japan, is the antibiotic with peptide pyrimidine nucleotide class formation.Its mechanism of action mainly is to disturb the chitinous biosynthesis of pathogenic cell wall, and gemma expands with part after mycelium contacts medicament and breaks, and overflows cell inclusion, causes death; In addition, this medicament suppresses the effect that germ produces spore and scab expansion in addition.Many disease funguses in sac fungi, basidiomycetes, the Fungi Imperfecti had higher activity, stability and safety are good, the market price is lower, mainly prevents and treats the multiple fungal diseases such as powdery mildew, gray mold, downy mildew, fusarium wilt and rice sheath blight disease of fruits and vegetables such as strawberry and grape, cucumber.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of the control to compose wide, low, effective Fluoxastrobin and the polyoxin composite bactericide of cost.
Fluoxastrobin of the present invention and polyoxin composite bactericide, its active ingredient is Fluoxastrobin and polyoxin, and the weight ratio of Fluoxastrobin and polyoxin is 20: 1～1: 20 in the composition, and preferable ratio is 10: 1～1: 10.
Bactericide of the present invention can be any one formulation of using with the suitable agricultural that known method is prepared into, and reasonable formulation is wetting powder, suspension emulsion, water dispersible granules, aqueous emulsion and microemulsion.The auxiliary agent that bactericide of the present invention uses comprises the known substance of the useful stable and drug effect performance in preparation of solvent, dispersant, emulsifier, stabilizing agent, antifreezing agent, thickener etc. and other, all be the various compositions of using or allow use in the pesticidal preparations always, be not particularly limited, concrete composition and consumption require to determine by simple experiment according to prescription.
The present invention can be applicable to prevent and treat the plurality of plant diseases that disease funguses such as basidiomycetes, imperfect fungus, oomycetes, sac fungi cause, be applicable to the crop pest of the various melons and fruits of control, vegetables, cereal class, particularly prevent and treat crop pests such as grape, strawberry, vegetables, cucumber, tomato, paddy rice, wheat, as grape scab, powdery mildew of strawberry, powdery mildew, rice blast, banded sclerotial blight, wheat powdery mildew, rust, sclerotinia rot of colza, pepper anthracnose, sigatoka, early blight of tomato and late blight etc.
Beneficial effect of the present invention is embodied in:
1. the used Fluoxastrobin of the present invention is the methoxy acrylic acid lipoid substance, and polyoxin is the novel agricultural antibiotic, both mechanism of action differences, and the action site difference does not have mutual pesticide resistance, and the germ that is mixed mutually is difficult for developing immunity to drugs.
2. but Synergistic reduces dosage, and use cost reduces.Use the Fluoxastrobin cost higher separately, be mixed with polyoxin, cost obviously reduces under the prerequisite that guarantees drug effect.
Embodiment
In order to make purpose of the present invention, technical scheme and advantage clearer, the present invention describes with following specific embodiment, but the present invention is limited to these examples absolutely not.The following stated only is the present invention embodiment preferably, only in order to explain the present invention, can not therefore be interpreted as the restriction of claim of the present invention.
Example of formulations of the present invention includes but not limited to as follows:
1. suspending agent embodiment
Press formula rate, after Fluoxastrobin and polyoxin active component, surfactant, thickener, film forming agent, carrier or filler and the mixing of part water, through high speed shear, the wet method sand milling is made semi-finished product, and moisturizing mixes filtration and promptly obtains finished product after analyzing.
Embodiment 1:21% Fluoxastrobin, polyoxin suspending agent
| 95% Fluoxastrobin (reactive compound) | 1.05g |
| 34% polyoxin (reactive compound) | 58.8g |
| Neopelex | 5g |
| Lignin sulfonic acid | 6g |
| Polyvinyl alcohol | 2.5g |
| Ethylene glycol (solvent) | 5g |
| Xanthans | 0.5g |
| S-29 | 0.5g |
| Water | 20.65g |
| Add up to | 100g |
Embodiment 2:16% Fluoxastrobin, polyoxin suspending agent
| 95% Fluoxastrobin (reactive compound) | 1.05g |
| 34% polyoxin (reactive compound) | 44.12g |
| Neopelex | 5g |
| Sodium lignin sulfonate | 1g |
| JFC | 2g |
| Magnesiumaluminumsilicate (auxiliary material) | 1g |
| Ethylene glycol (solvent) | 5g |
| Water | 41.83g |
| Add up to | 100g |
2. wetting powder embodiment
Pesticide activity component Fluoxastrobin and polyoxin, auxiliary agent, filler are mixed the mixed again wetting powder that gets behind comminution by gas stream in proportion.Capital equipment: mixer, airslide disintegrating mill.
Embodiment 3:11% Fluoxastrobin, polyoxin wetting powder
| 95% Fluoxastrobin (reactive compound) | ?1.05g |
| 34% polyoxin (reactive compound) | ?29.41g |
| Sodium lignin sulfonate | ?5.5g |
| The withered powder of tea | ?4.5g |
| Draw back powder | ?1.5g |
| White carbon | ?0.5g |
| Kaolin | ?57，54g |
| Add up to | ?100g |
Embodiment 4:20% Fluoxastrobin, polyoxin wetting powder
| 93% Fluoxastrobin (reactive compound) | 10.53g |
| 34% polyoxin (reactive compound) | 29.41g |
| Sodium lignin sulfonate (dispersant) | 6g |
| Lauryl sodium sulfate (dispersant) | 5g |
| Bentonite (filler) | 10g |
| Diatomite | 39.06g |
| Add up to | 100g |
3. microemulsion, aqueous emulsion embodiment
By each set of dispense ratio, Fluoxastrobin and polyoxin solubilization of active ingredient in solvent and in the cosolvent, are added surfactant, mix and make oil phase.With water-soluble component and the mixed water that gets of water, again oil phase is added aqueous phase or water and add in the oil phase, the limit edged stirs, and makes microemulsion and aqueous emulsion.
Embodiment 5:12% Fluoxastrobin, polyoxin microemulsion
| 95% Fluoxastrobin (reactive compound) | 10.53g |
| 34% polyoxin (reactive compound) | 5.88g |
| DMF (solvent) | 10g |
| Dimethylbenzene (solvent) | 15g |
| Propane diols (solvent) | 7.5g |
| Castor oil polyoxyethylene ether (emulsifier) | 8g |
| Calcium dodecyl benzene sulfonate (surfactant) | 4.5g |
| Water | 38.59g |
| Add up to | 100g |
Embodiment 6:11% Fluoxastrobin, polyoxin aqueous emulsion
| 95% Fluoxastrobin (reactive compound) | 10.53g |
| 34% polyoxin (reactive compound) | 2.94g |
| DMF (solvent) | 5g |
| Dimethylbenzene (solvent) | 10g |
| Glycerine (antifreeze) | 5g |
| Phenethyl phenol polyethenoxy ether (emulsifier) | 8g |
| Calcium dodecyl benzene sulfonate (surfactant) | 5g |
| Water | 53.53g |
| Add up to | 100g |
4. water-dispersible granules embodiment
Pesticide activity component Fluoxastrobin and polyoxin, auxiliary agent, filler are mixed in proportion through comminution by gas stream, add the water of 15-20% then, make the water dispersible granules product through kneading, granulation, drying, screening.Capital equipment: mixer, airslide disintegrating mill, kneader, Squeezinggranulator, drying equipment (drying room or fluid bed).
Embodiment 7:42% Fluoxastrobin, polyoxin water dispersant
Application Example:
1. Fluoxastrobin and polyoxin are composite measures the powdery mildew of cucumber pot experiment
Subjects: powdery mildew of strawberry bacterium (the Strawberry powdery mildew that picks up from the field; )
Test method: with reference to " the agricultural industry criteria NY/T1156.11-2008 of the People's Republic of China (PRC) ". the cucumber seedling of choosing the growth potential basically identical is as experiment material, and 3 basin cucumber seedlings are selected in each processing for use, and numbering is for examination.The sick leaf of the powdery mildew of cucumber of picking up from the field is evenly shaken off conidium inoculate above cucumber seedling, inoculation back 24h carries out chemicals treatment, and test medicine is sprayed under 50PSI pressure with the Potter spray tower referring to table 1., every basin 5ml.Contrast blank to spray being treated to of equivalent clear water.After the spraying cucumber seedling being put into the greenhouse cultivates.Behind the 7d,, and calculate control efficiency according to the morbidity grade scale complete stool investigation disease index of powdery mildew of cucumber.
Disease index (%)=∑ (each grade blade morbidity number * this grade typical value)/(investigation total leaf number * highest typical value) * 100
Control efficiency (%)=(contrast disease index-processing disease index)/contrast disease index * 100
Control efficiency is converted into probability value (y), and liquor strength (ug/ml) converts logarithm value (x) to, calculates concentration EC50 in virulence equation and the inhibition with method of least squares, calculates the toxicity index and the co-toxicity coefficient (CTC) of medicament according to the abundant method of Sun Yun.
Actual measurement toxicity index (ATI)=(standard medicament EC50/ reagent agent EC50) * 100
The percentage composition of B in percentage composition+B medicament toxicity index * mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixture
Co-toxicity coefficient (CTC)=(mixture actual measurement toxicity index (the ATI)/theoretical toxicity index (TTI) of mixture) * 100
When CTC≤80, then the composition performance is for antagonism, and when 80＜CTC＜120, then the composition performance is for summation action, and when CTC 〉=120, then the composition performance is synergistic effect.
Table 1 Fluoxastrobin and polyoxin are composite to powdery mildew of cucumber pot experiment measurement result
| Handle | ?EC 50(ug/ml) | ATI | TTI | Co-toxicity coefficient CTC |
| Fluoxastrobin | 5.87 | 100 | -- | -- |
| Polyoxin | 18.59 | 32 | -- | -- |
| Fluoxastrobin 1: polyoxin 20 | 13.66 | 38.62 | 26.75 | 118.32 |
| Fluoxastrobin 1: polyoxin 15 | 8.47 | 76.42 | 43.47 | 148.46 |
| Fluoxastrobin 1: polyoxin 10 | 5.28 | 124.54 | 68.76 | 175.76 |
| Fluoxastrobin 1: polyoxin 1 | 4.85 | 172.46 | 89.45 | 188.54 |
| Fluoxastrobin 5: polyoxin 1 | 3.47 | 186.78 | 96.69 | 211.56 |
| Fluoxastrobin 10: polyoxin 1 | 3.89 | 175.45 | 91.43 | 193.54 |
| Fluoxastrobin 20: polyoxin 1 | 4.13 | 112.52 | 63.16 | 162.65 |
Table 1 measurement result shows that Fluoxastrobin and polyoxin have synergistic effect to the powdery mildew of cucumber bacterium between proportioning 20: 1～1: 20, and between 1: 10～10: 1, synergistic effect is obvious, and 5: 1 o'clock, co-toxicity coefficient was more than 200.
2. Fluoxastrobin and polyoxin are composite to strawberry anthracnose Toxicity Determination.
Subjects: the strawberry anthrax bacteria (Colletotrichum gloeosporioides) that picks up from the field
Test method: with reference to " the agricultural industry criteria NY/T1156.2-2006 of the People's Republic of China (PRC) ".With strawberry anthrax bacteria PDA medium culture, when treating that bacterium colony has just covered with culture dish, punch from the edge with the card punch of internal diameter 7mm, the mycelia piece that breaks into is as inoculum.Get the soup 5ml for preparing and quantitative 75ml sterilising medium respectively and mix, make 4 pastille flat boards, be mixed into contrast with equivalent sterile water and medium.The inversion of mycelia piece is connected to dull and stereotyped central authorities, and in 28 ℃ of incubators, cultivates.Behind the 7d, measure colony diameter, calculate and respectively handle the clean amount of growth of mycelia, mycelial growth inhibition rate with the right-angled intersection method.
Clean amount of growth (mm)=measurement colony diameter-7
Mycelial growth rate (%)=((the clean amount of growth of the clean amount of growth-processed group of control group)/clean amount of growth of control group) * 100
The mycelial growth rate conversion is become probability value (y), and liquor strength (ug/ml) converts logarithm value (x) to, calculates concentration EC50 in virulence equation and the inhibition with method of least squares, calculates the toxicity index and the co-toxicity coefficient (CTC) of medicament according to the abundant method of Sun Yun.
Result's (table 2) shows that Fluoxastrobin and polyoxin have obvious synergistic effect to strawberry anthracnose between proportioning 20: 1～1: 20, and especially between 5: 1～10: 1, synergistic effect is more obvious, and co-toxicity coefficient is more than 200.
Table 2 Fluoxastrobin and polyoxin are composite to strawberry anthracnose Toxicity Determination result
| Handle | ?EC 50(ug/ml) | ATI | TTI | Co-toxicity coefficient CTC |
| Fluoxastrobin | 6.63 | 100 | -- | -- |
| Polyoxin | 26.47 | 32.00 | -- | -- |
| Fluoxastrobin 1: polyoxin 20 | 16.42 | 47.38 | 35.47 | 126.43 |
| Fluoxastrobin 1: polyoxin 15 | 12.53 | 50.48 | 36.89 | 136.36 |
| Fluoxastrobin 1: polyoxin 10 | 8.42 | 64.42 | 57.43 | 160.47 |
| Fluoxastrobin 1: polyoxin 1 | 5.58 | 115.48 | 87.47 | 186.43 |
| Fluoxastrobin 5: polyoxin 1 | 3.26 | 194.56 | 97.52 | 214.65 |
| Fluoxastrobin 10: polyoxin 1 | 2.88 | 210.32 | 92.46 | 235.44 |
| Fluoxastrobin 20: polyoxin 1 | 4.32 | 136.31 | 90.26 | 196.48 |
3. the composite field trial of Fluoxastrobin and polyoxin to rice sheath blight disease
Test is handled: this test medicine consumption is provided with respective table respectively according to the difference of each embodiment composition, and the contrast medicament is commercially available 25% Fluoxastrobin water suspension emulsion (SC) and 3% polyoxin wetting powder (WP) and blank (CK) clear water test.
Test method: the test and Selection rice varieties is for pressing down rice No. 10, and in the rice tillering Sheng phase on July 18th, 2010, this moment, banded sclerotial blight began morbidity.Testing each sub-district is 50m2, repeat 3 times, investigation incidence before the dispenser, the dispenser sub-district every the 7d medication once, continuous three times, 7d field investigation preventive effect behind medicine for the third time; Inspection drug effect method before the dispenser after investigation and the control is: 5 samplings of every sub-district diagonal, every is extracted continuous 5 clumps, writes down total strain number, diseased plant rate, diseased plant number and sick level rate.Check the banded sclerotial blight occurrence degree.Calculate disease index and control efficiency.
Disease index=[∑ (sick level * corresponding sick level strain number)/(total strain number * 9)] * 100
Control efficiency (%)=[1-(CK0 disease index * PT1 disease index)/(CK1 disease index * PT0 disease index)] * 100
CK0: blank district disease index before the dispenser; CK1: blank district disease index after the dispenser; PT1: dispenser post processing zone disease index; PT0: dispenser pre-treatment district disease index.
Result of the test sees Table 3:
The composite field test results of table 3 Fluoxastrobin and polyoxin to rice sheath blight disease
Claims (3)
1. Fluoxastrobin and polyoxin composite bactericide, it is characterized in that: its active ingredient is Fluoxastrobin and polyoxin, the weight ratio of Fluoxastrobin and polyoxin is 20 ︰, 1～1 ︰ 20 in the composition.
2. Fluoxastrobin according to claim 1 and polyoxin composite bactericide is characterized in that: the weight ratio of Fluoxastrobin and polyoxin is 10 ︰, 1～1 ︰ 10.
3. Fluoxastrobin according to claim 1 and 2 and polyoxin composite bactericide is characterized in that: this bactericide is a kind of in wetting powder, suspension emulsion, water dispersible granules, aqueous emulsion and the microemulsion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101398811A CN102239862A (en) | 2011-05-27 | 2011-05-27 | Compound bactericide of azoxystrobin and polyoxin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101398811A CN102239862A (en) | 2011-05-27 | 2011-05-27 | Compound bactericide of azoxystrobin and polyoxin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102239862A true CN102239862A (en) | 2011-11-16 |
Family
ID=44958253
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011101398811A Pending CN102239862A (en) | 2011-05-27 | 2011-05-27 | Compound bactericide of azoxystrobin and polyoxin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102239862A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104106600A (en) * | 2013-04-19 | 2014-10-22 | 陕西美邦农药有限公司 | Sterilization composition containing tricyclopyricarb and antibiotic |
| CN104351254B (en) * | 2014-10-30 | 2016-09-14 | 陕西麦可罗生物科技有限公司 | A kind of containing Nikemycin with the bactericidal composition of Fluoxastrobin |
| CN109077058A (en) * | 2018-08-13 | 2018-12-25 | 广东顾地丰生物科技有限公司 | A kind of composite bactericide composition of fluorine-containing azoles bacterium acyl azanol and polyoxin |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102067851A (en) * | 2011-01-20 | 2011-05-25 | 陕西美邦农药有限公司 | Antibacterial composition containing polyoxin and methoxyacrylate compound |
-
2011
- 2011-05-27 CN CN2011101398811A patent/CN102239862A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102067851A (en) * | 2011-01-20 | 2011-05-25 | 陕西美邦农药有限公司 | Antibacterial composition containing polyoxin and methoxyacrylate compound |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104106600A (en) * | 2013-04-19 | 2014-10-22 | 陕西美邦农药有限公司 | Sterilization composition containing tricyclopyricarb and antibiotic |
| CN104106600B (en) * | 2013-04-19 | 2018-07-10 | 陕西美邦农药有限公司 | A kind of bactericidal composition containing chlorine nalidixic bacterium ester and antibiotics |
| CN104351254B (en) * | 2014-10-30 | 2016-09-14 | 陕西麦可罗生物科技有限公司 | A kind of containing Nikemycin with the bactericidal composition of Fluoxastrobin |
| CN109077058A (en) * | 2018-08-13 | 2018-12-25 | 广东顾地丰生物科技有限公司 | A kind of composite bactericide composition of fluorine-containing azoles bacterium acyl azanol and polyoxin |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101669486B (en) | Benzolkresoxim-methyl containing bactericide composition | |
| CN102172240B (en) | A kind of bactericidal composition containing benziothiazolinone and methoxy acrylic bactericide | |
| CN101595882B (en) | Pesticide composition containing methoxyl acrylic ester bactericide | |
| CN101647441B (en) | Sterilization combination containing azoxystrobin and application thereof | |
| CN101595887A (en) | A kind of bactericidal composition that contains Prochloraz | |
| CN101690480B (en) | Pesticide composition containing methoxy acrylic bactericide and application thereof | |
| CN105961399B (en) | Bactericidal composition and its application | |
| CN101690483A (en) | Bactericidal composition containing triazole class compounds | |
| CN101816308A (en) | Bactericidal composition | |
| CN101647454A (en) | Sterilizing composition containing cyprodinil | |
| CN101642104A (en) | Sterilization composition containing fenoxanil | |
| CN101595889A (en) | A kind of bactericidal composition that contains iprodione | |
| CN101669524B (en) | Bactericide composition with tetraconazole | |
| CN101658175A (en) | Pesticide composition and application thereof | |
| CN101653131B (en) | Bactericidal composition containing azoxystrobin | |
| CN101658171A (en) | Pesticide composition and application thereof | |
| CN101669474A (en) | Bactericidal composition containing kresoxim-methyl phenylate | |
| CN101779645A (en) | Azoxystrobin composite and application thereof | |
| CN101658173A (en) | Sterilization composition containing tetraconazole | |
| CN102239862A (en) | Compound bactericide of azoxystrobin and polyoxin | |
| CN107251900A (en) | A kind of composition pesticide and its application of fluorine-containing azoles bacterium acyl azanol and Prochloraz | |
| CN101697725A (en) | Pesticide composition containing protective bactericide | |
| CN101755761B (en) | Fluquinconazole-based synergistic pesticide composition | |
| CN103190420B (en) | Propiconazole-containing bactericidal composition | |
| CN101849546A (en) | Pesticide composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20111116 |