CN107460123A - A kind of femoral head H hypotype vascular endothelial cell culture apparatuses of improvement - Google Patents
A kind of femoral head H hypotype vascular endothelial cell culture apparatuses of improvement Download PDFInfo
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- CN107460123A CN107460123A CN201710653782.2A CN201710653782A CN107460123A CN 107460123 A CN107460123 A CN 107460123A CN 201710653782 A CN201710653782 A CN 201710653782A CN 107460123 A CN107460123 A CN 107460123A
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- nutrient solution
- housing
- ascending pipe
- hypotype
- supporting plate
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/22—Transparent or translucent parts
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/38—Caps; Covers; Plugs; Pouring means
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/20—Air quality improvement or preservation, e.g. vehicle emission control or emission reduction by using catalytic converters
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- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
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- Biomedical Technology (AREA)
- Sustainable Development (AREA)
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- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Clinical Laboratory Science (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention discloses a kind of femoral head H hypotype vascular endothelial cell culture apparatuses of improvement,Including housing,The lower end of the housing offers culture dish and is put into mouth,The upper end of the housing is rotatably connected to transparent sleeve joint shell,Nutrient solution ascending pipe is slidably connected in the middle part of the transparent sleeve joint shell,The lower end of the nutrient solution ascending pipe is integrally formed with nutrient solution outlet,The bottom surface that the culture dish is put into mouth is fixedly connected with screw rod,The lateral wall of the screw rod is bolted with extruded sleeve,The upper end of the extruded sleeve is fitted with training device,The present invention passes through housing,The use of transparent sleeve joint shell and supporting plate,Realize and cell cultivation groove is completely disposed in closing space,Avoid the entrance of outside bacterium,The present invention realizes the function that can add nutrient solution together by nutrient solution ascending pipe and being used cooperatively for jacking block simultaneously,Avoid and add the problem of nutrient solution is lost time one by one.
Description
Technical field
The present invention relates to cell culture apparatus technical field, the femoral head H hypotype blood vessel endotheliums of specially a kind of improvement are thin
Born of the same parents' culture apparatus.
Background technology
Cell culture apparatus is often used in cell culture, and when cultivating cell now often in sterilized space
Cell culture is carried out using culture dish, but sterilized space now is because can not accomplish completely and outer closures, simultaneously
Needed when can not realize the effect of integral asepsis, and cell being cultivated now people manually one by one to culture dish add train
Nutrient solution, the working time of people is so extended, we have proposed a kind of femoral head H hypotype vascular endothelial cells of improvement for this
Culture apparatus.
The content of the invention
It is an object of the invention to provide a kind of femoral head H hypotype vascular endothelial cell culture apparatuses of improvement, to solve
The problem of being proposed in above-mentioned background technology.
To achieve the above object, the present invention provides following technical scheme：A kind of femoral head H hypotype blood vessel endotheliums of improvement are thin
Born of the same parents' culture apparatus, including housing, the lower end of the housing offer culture dish and are put into mouth, and the middle part of the lateral wall of the housing is left
End is fixedly connected with active gases inlet port, and the right-hand member of the lateral wall of the housing is fixedly connected with outlet port, the shell
The upper end of body is rotatably connected to transparent sleeve joint shell, and the front end of the upper surface of the transparent sleeve joint shell is embedded with amplifying observation hole, and
The right side in amplifying observation hole is provided with biological cell thief hole, and nutrient solution injection is slidably connected in the middle part of the transparent sleeve joint shell
Pipe, and nutrient solution ascending pipe and transparent sleeve joint shell junction are provided with the first spring, the upper end of the nutrient solution ascending pipe it is integral into
Type has threaded joint, and the lower end of the nutrient solution ascending pipe is integrally formed with nutrient solution outlet, the inner chamber of the nutrient solution ascending pipe
Lower end is socketed with closure plug, and the upper surface of the closure plug is fitted with second spring, and the bottom surface that the culture dish is put into mouth is fixed
Screw rod is connected with, the lateral wall of the screw rod is bolted with extruded sleeve, and the lateral wall of the extruded sleeve is described integrally formed with rotating disk
The upper end of extruded sleeve is fitted with training device；
The culture apparatus includes supporting plate, and bottom surface and the extruded sleeve of the supporting plate fit, the supporting plate it is upper
Surface is fixedly connected with spacing collar, the limit uniformly integrally formed with cell cultivation groove in the middle part of the upper surface of the supporting plate
The lateral wall of position circle offers nutrient solution tap hole, and the nutrient solution tap hole communicates with cell cultivation groove, the spacing collar
Middle part is fixedly connected with jacking block, and the jacking block is relative with closure plug.
Preferably, the upper surface of the supporting plate is fitted with cushion rubber.
Preferably, the upper surface of the extruded sleeve is rotatably connected to swivel becket.
Compared with prior art, the beneficial effects of the invention are as follows：A kind of femoral head H hypotypes vascular endothelial cell training of improvement
Device is supported, the present invention realizes cell cultivation groove being completely disposed at closing by the use of housing, transparent sleeve joint shell and supporting plate
In space, the entrance of outside bacterium is avoided, while the present invention is realized by nutrient solution ascending pipe and being used cooperatively for jacking block
The function of nutrient solution can be added together, avoided and added the problem of nutrient solution is lost time one by one.
Brief description of the drawings
Fig. 1 is schematic structural view of the invention；
Fig. 2 is section of structure of the present invention；
Fig. 3 is culture apparatus structure chart of the present invention；
Fig. 4 is present invention closure plug structure schematic diagram.
In figure：1 housing, 2 culture dishes are put into mouth, 3 active gases inlet ports, 4 outlet ports, 5 transparent sleeve joint shells, 6 put
Big peep hole, 7 biological cell thief holes, 8 nutrient solution ascending pipes, 9 first springs, 10 threaded joints, 11 nutrient solution outlets, 12 envelopes
Blocking, 13 second springs, 14 screw rods, 15 extruded sleeves, 16 rotating disks, 17 culture apparatuses, 171 supporting plates, 172 cell cultivation grooves,
173 spacing collars, 174 nutrient solution tap holes, 175 jacking blocks, 18 cushion rubbers, 19 swivel beckets, 20 cappings.
Embodiment
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clear, complete
Site preparation describes, it is clear that described embodiment is only part of the embodiment of the present invention, rather than whole embodiments.It is based on
Embodiment in the present invention, those of ordinary skill in the art are obtained every other under the premise of creative work is not made
Embodiment, belong to the scope of protection of the invention.
Fig. 1-4 are referred to, the present invention provides a kind of technical scheme：A kind of femoral head H hypotype vascular endothelial cells of improvement
Culture apparatus, including housing 1, the lower end of the housing 1 offer culture dish and are put into mouth 2, the middle part of the lateral wall of the housing 1
Left end is fixedly connected with active gases inlet port 3, and the right-hand member of the lateral wall of the housing 1 is fixedly connected with outlet port 4, institute
The upper end for stating housing 1 is rotatably connected to transparent sleeve joint shell 5, and the front end of the upper surface of the transparent sleeve joint shell 5 is embedded with amplification and seen
Hole 6 is examined, and the right side in amplifying observation hole 6 is provided with biological cell thief hole 7, the middle part of the transparent sleeve joint shell 5 slidably connects
Nutrient solution ascending pipe 8, and nutrient solution ascending pipe 8 is provided with the first spring 9, the nutrient solution injection with the transparent junction of sleeve joint shell 5
The upper end of pipe 8 is integrally formed with threaded joint 10, and the lower end of the nutrient solution ascending pipe 8 is integrally formed with nutrient solution outlet 11, institute
The inner chamber lower end for stating nutrient solution ascending pipe 8 is socketed with closure plug 12, and the upper surface of the closure plug 12 is fitted with second spring 13,
The bottom surface that the culture dish is put into mouth 2 is fixedly connected with screw rod 14, and the lateral wall of the screw rod 14 is bolted with extruded sleeve 15, described
The lateral wall of extruded sleeve 15 is fitted with training device 17 integrally formed with rotating disk 16, the upper end of the extruded sleeve 15；
The culture apparatus 17 includes supporting plate 171, and bottom surface and the extruded sleeve 15 of the supporting plate 171 fit, described
The upper surface of supporting plate 171 is uniformly fixed integrally formed with cell cultivation groove 172, the middle part of the upper surface of the supporting plate 171
Spacing collar 173 is connected with, the lateral wall of the spacing collar 173 offers nutrient solution tap hole 174, the nutrient solution tap hole
174 communicate with cell cultivation groove 172, and the middle part of the spacing collar 173 is fixedly connected with jacking block 175, the jacking block 175 and closure
It is relative to fill in 12.
The present invention is realized by the use of housing 1, transparent sleeve joint shell 5 and supporting plate 171 and is put cell cultivation groove completely
In the entrance in closing space, avoiding outside bacterium, while the present invention passes through the cooperation of nutrient solution ascending pipe 8 and jacking block 175
The function that can add nutrient solution together using realizing, avoid and add the problem of nutrient solution is lost time one by one.
Specifically, the upper surface of the supporting plate 171 is fitted with cushion rubber 18, prevents supporting plate 171 from connecting with the bottom surface of housing 1
Connect it is not close, the problem of so as to cause bacterium to enter.
Specifically, the upper surface of the extruded sleeve 15 is rotatably connected to swivel becket 19, prevents when rotating extruded sleeve 15
Supporting plate 171 is driven to rotate.
Specifically, the upper end of the biological cell thief hole 7 is bolted with capping 20, prevents that outside bacterium is thin from biology
Born of the same parents' thief hole 7 enters in housing 1.
Operation principle：The cell of culture is put into cell cultivation groove 172 by the present invention when in use, then by supporting plate
171 prevent that cell cultivation groove 172 is squeezed into housing 1 in extruded sleeve 15, while the bottle of external nutrition liquid is screwed onto
On threaded joint 10, when people need to make to adding nutrient solution in cell cultivation groove 172, threaded joint 10, the now meeting of jacking block 175 are pressed
Now nutrient solution will flow into spacing collar 173 out of nutrient solution ascending pipe 8 extruding closure plug 12, so as to which nutrient solution can be from spacing
Nutrient solution tap hole 174 on circle 173 is flowed into cell cultivation groove 172, while active gases can be put into mouth 2 from culture dish and lead to
Enter, waste gas can discharge from outlet port 4, can be revolved when people need to examine the culture cell in cell cultivation groove 172
Turn transparent sleeve joint shell 5 and watched from amplifying observation hole 6.
Although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
A variety of changes, modification can be carried out to these embodiments, replace without departing from the principles and spirit of the present invention by understanding
And modification, the scope of the present invention is defined by the appended.
Claims (4)
1. a kind of femoral head H hypotype vascular endothelial cell culture apparatuses of improvement, including housing (1), it is characterised in that：The shell
The lower end of body (1) offers culture dish and is put into mouth (2), and the middle part left end of the lateral wall of the housing (1) is fixedly connected active
Gas entrance (3), the right-hand member of the lateral wall of the housing (1) are fixedly connected with outlet port (4), the housing (1)
Upper end is rotatably connected to transparent sleeve joint shell (5), and the front end of the upper surface of the transparent sleeve joint shell (5) is embedded with amplifying observation hole
(6), and the right side of amplifying observation hole (6) is provided with biological cell thief hole (7), and the middle part of the transparent sleeve joint shell (5), which is slided, to be connected
Nutrient solution ascending pipe (8) is connected to, and nutrient solution ascending pipe (8) is provided with the first spring (9), institute with transparent sleeve joint shell (5) junction
The upper end for stating nutrient solution ascending pipe (8) is integrally formed integrally formed with threaded joint (10), the lower end of the nutrient solution ascending pipe (8)
Nutritious liquid exports (11), and the inner chamber lower end of the nutrient solution ascending pipe (8) is socketed with closure plug (12), the closure plug (12)
Upper surface be fitted with second spring (13), the bottom surface that the culture dish is put into mouth (2) is fixedly connected with screw rod (14), the spiral shell
The lateral wall of bar (14) is bolted with extruded sleeve (15), and the lateral wall of the extruded sleeve (15) is described integrally formed with rotating disk (16)
The upper end of extruded sleeve (15) is fitted with training device (17)；
The culture apparatus (17) includes supporting plate (171), and bottom surface and the extruded sleeve (15) of the supporting plate (171) fit,
The upper surface of the supporting plate (171) is uniformly integrally formed with cell cultivation groove (172), the upper surface of the supporting plate (171)
Middle part be fixedly connected with spacing collar (173), the lateral wall of the spacing collar (173) offers nutrient solution tap hole (174), institute
State nutrient solution tap hole (174) to communicate with cell cultivation groove (172), jacking block is fixedly connected with the middle part of the spacing collar (173)
(175), the jacking block (175) is relative with closure plug (12).
2. a kind of femoral head H hypotype vascular endothelial cell culture apparatuses of improvement according to claim 1, its feature exist
In：The upper surface of the supporting plate (171) is fitted with cushion rubber (18).
3. a kind of femoral head H hypotype vascular endothelial cell culture apparatuses of improvement according to claim 1, its feature exist
In：The upper surface of the extruded sleeve (15) is rotatably connected to swivel becket (19).
4. a kind of femoral head H hypotype vascular endothelial cell culture apparatuses of improvement according to claim 1, its feature exist
In：The upper end of the biological cell thief hole (7) is bolted with capping (20).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710653782.2A CN107460123B (en) | 2017-07-19 | 2017-07-19 | Improved femoral head H subtype vascular endothelial cell culture device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710653782.2A CN107460123B (en) | 2017-07-19 | 2017-07-19 | Improved femoral head H subtype vascular endothelial cell culture device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107460123A true CN107460123A (en) | 2017-12-12 |
| CN107460123B CN107460123B (en) | 2023-06-13 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710653782.2A Active CN107460123B (en) | 2017-07-19 | 2017-07-19 | Improved femoral head H subtype vascular endothelial cell culture device |
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| Country | Link |
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| CN (1) | CN107460123B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110331095A (en) * | 2019-06-11 | 2019-10-15 | 华夏源（上海）细胞基因工程股份有限公司 | A kind of stem cell nutrient solution adding device and its application method |
| CN112899137A (en) * | 2021-04-09 | 2021-06-04 | 赵福振 | Fermentation device for pickled products rich in organic biological zinc and selenium |
| CN112997949A (en) * | 2021-03-03 | 2021-06-22 | 赵福振 | Fish nutrient solution culture device rich in bioactive nano organic zinc selenium |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110331095A (en) * | 2019-06-11 | 2019-10-15 | 华夏源（上海）细胞基因工程股份有限公司 | A kind of stem cell nutrient solution adding device and its application method |
| CN112997949A (en) * | 2021-03-03 | 2021-06-22 | 赵福振 | Fish nutrient solution culture device rich in bioactive nano organic zinc selenium |
| CN112899137A (en) * | 2021-04-09 | 2021-06-04 | 赵福振 | Fermentation device for pickled products rich in organic biological zinc and selenium |
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| Publication number | Publication date |
|---|---|
| CN107460123B (en) | 2023-06-13 |
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