CN107427666B - 脊髓软膜下基因递送系统 - Google Patents

脊髓软膜下基因递送系统 Download PDF

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CN107427666B
CN107427666B CN201580078566.9A CN201580078566A CN107427666B CN 107427666 B CN107427666 B CN 107427666B CN 201580078566 A CN201580078566 A CN 201580078566A CN 107427666 B CN107427666 B CN 107427666B
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subpial
delivery system
aav9
gene delivery
spinal cord
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CN107427666A (zh
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马丁.马尔萨拉
宮之原厚司
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University of California San Diego UCSD
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/04—Macromolecular materials
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CN201580078566.9A 2015-01-30 2015-12-15 脊髓软膜下基因递送系统 Active CN107427666B (zh)

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US201562110340P 2015-01-30 2015-01-30
US62/110,340 2015-01-30
PCT/US2015/065704 WO2016122791A1 (en) 2015-01-30 2015-12-15 Spinal subpial gene delivery system

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WO2016122791A1 (en) 2016-08-04
EP3250279A1 (en) 2017-12-06
CA2975447A1 (en) 2016-08-04
JP2025015673A (ja) 2025-01-30
JP2021181456A (ja) 2021-11-25
JP2023060308A (ja) 2023-04-27
CN107427666A (zh) 2017-12-01
US20180008727A1 (en) 2018-01-11

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