CN107427585A - 艾菲康唑的晶型 - Google Patents

艾菲康唑的晶型 Download PDF

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Publication number
CN107427585A
CN107427585A CN201580073938.9A CN201580073938A CN107427585A CN 107427585 A CN107427585 A CN 107427585A CN 201580073938 A CN201580073938 A CN 201580073938A CN 107427585 A CN107427585 A CN 107427585A
Authority
CN
China
Prior art keywords
efeconazole
crystalline
powder diffraction
ray powder
diffraction pattern
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201580073938.9A
Other languages
English (en)
Chinese (zh)
Inventor
伊太·埃丁
希拉·埃拉扎里-沙洛姆
奥里·罗里尔克
雅纳·塞里
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wavelength Pharmaceuticals Ltd
Original Assignee
Perrigo API Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perrigo API Ltd filed Critical Perrigo API Ltd
Publication of CN107427585A publication Critical patent/CN107427585A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201580073938.9A 2015-01-20 2015-12-02 艾菲康唑的晶型 Pending CN107427585A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562105390P 2015-01-20 2015-01-20
US62/105,390 2015-01-20
PCT/IL2015/051171 WO2016116919A1 (en) 2015-01-20 2015-12-02 Crystalline forms of efinaconazole

Publications (1)

Publication Number Publication Date
CN107427585A true CN107427585A (zh) 2017-12-01

Family

ID=56416514

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580073938.9A Pending CN107427585A (zh) 2015-01-20 2015-12-02 艾菲康唑的晶型

Country Status (8)

Country Link
US (1) US20180002310A1 (https=)
EP (1) EP3247399A4 (https=)
JP (1) JP2018502165A (https=)
CN (1) CN107427585A (https=)
AU (1) AU2015379251A1 (https=)
CA (1) CA2974180A1 (https=)
IL (1) IL253479A0 (https=)
WO (1) WO2016116919A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106995434A (zh) * 2016-01-25 2017-08-01 广东东阳光药业有限公司 一种三唑类抗真菌药的晶型及其制备方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102597119B1 (ko) 2017-05-19 2023-11-01 가껭세이야꾸가부시기가이샤 에피나코나졸의 제조 및 정제 방법
US20210363129A1 (en) * 2018-12-29 2021-11-25 Viwit Pharmaceutical Co., Ltd. Preparation method for efinaconazole
JP2021054781A (ja) * 2019-09-26 2021-04-08 デボン エルエス，リミテッド 共結晶形エフィナコナゾール、及びその製造方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1122598A (zh) * 1993-05-10 1996-05-15 科研制药株式会社 吡咯胺衍生物
WO2001007643A1 (en) * 1999-07-28 2001-02-01 Kaken Pharmaceutical Co., Ltd. Method for detecting pathogenic microorganism and antimicrobial agent, method for evaluating the drug effect of antimicrobial agent, and antimicrobial agents
CN103080100A (zh) * 2010-08-31 2013-05-01 科研制药株式会社 1-三唑-2-丁醇衍生物的制造方法
CN104292214A (zh) * 2014-09-24 2015-01-21 南京华威医药科技开发有限公司 艾氟康唑及其中间体的合成方法
CN104327047A (zh) * 2014-10-17 2015-02-04 苏州明锐医药科技有限公司 艾菲康唑的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3437695B2 (ja) * 1993-05-10 2003-08-18 科研製薬株式会社 アゾリルアミン誘導体
US8889155B2 (en) * 2006-12-28 2014-11-18 Kaken Pharmaceutical Co., Ltd. Gel composition for treating mycosis
WO2008124131A1 (en) * 2007-04-05 2008-10-16 The John Hopkins University Antifungal agents as neuroprotectants
US20090175810A1 (en) * 2008-01-03 2009-07-09 Gareth Winckle Compositions and methods for treating diseases of the nail
FR2938066B1 (fr) * 2008-11-06 2010-12-17 Centre Nat Rech Scient Systeme et procede d'analyse quantitative de la composition elementaire de la matiere par spectroscopie du plasma induit par laser (libs)
WO2016181306A1 (en) * 2015-05-12 2016-11-17 Lupin Limited Process for the preparation of efinaconazole
WO2016193917A1 (en) * 2015-06-04 2016-12-08 Glenmark Pharmaceuticals Limited Process for the preparation of efinaconazole

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1122598A (zh) * 1993-05-10 1996-05-15 科研制药株式会社 吡咯胺衍生物
WO2001007643A1 (en) * 1999-07-28 2001-02-01 Kaken Pharmaceutical Co., Ltd. Method for detecting pathogenic microorganism and antimicrobial agent, method for evaluating the drug effect of antimicrobial agent, and antimicrobial agents
CN103080100A (zh) * 2010-08-31 2013-05-01 科研制药株式会社 1-三唑-2-丁醇衍生物的制造方法
CN104292214A (zh) * 2014-09-24 2015-01-21 南京华威医药科技开发有限公司 艾氟康唑及其中间体的合成方法
CN104327047A (zh) * 2014-10-17 2015-02-04 苏州明锐医药科技有限公司 艾菲康唑的制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HIRONOBU OGURA等: "Synthesis and antifungal activities of (2R,3R)-2-aryl-1-azolyl-3-(substituted amino)-2-butanol derivatives as topical antifungal agents", 《CHEM. PHARM. BULL.》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106995434A (zh) * 2016-01-25 2017-08-01 广东东阳光药业有限公司 一种三唑类抗真菌药的晶型及其制备方法

Also Published As

Publication number Publication date
US20180002310A1 (en) 2018-01-04
EP3247399A1 (en) 2017-11-29
IL253479A0 (en) 2017-09-28
JP2018502165A (ja) 2018-01-25
CA2974180A1 (en) 2016-07-28
AU2015379251A1 (en) 2017-07-27
WO2016116919A1 (en) 2016-07-28
EP3247399A4 (en) 2018-09-05

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Application publication date: 20171201

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