CN107412724A - 预防或治疗代谢综合症的方法 - Google Patents
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- CN107412724A CN107412724A CN201710423699.6A CN201710423699A CN107412724A CN 107412724 A CN107412724 A CN 107412724A CN 201710423699 A CN201710423699 A CN 201710423699A CN 107412724 A CN107412724 A CN 107412724A
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| US8470784B2 (en) | 2009-08-24 | 2013-06-25 | Stealth Peptides International, Inc. | Methods and compositions for preventing or treating ophthalmic conditions |
| JP2013506696A (ja) | 2009-10-05 | 2013-02-28 | コーネル ユニヴァーシティー | 心不全の予防又は処置の方法 |
| AU2010339414A1 (en) * | 2009-12-31 | 2012-07-19 | Stealth Peptides International, Inc. | Methods for performing a coronary artery bypass graft procedure |
| DK2830644T3 (en) * | 2012-03-30 | 2017-02-27 | Stealth Peptides Int Inc | Methods and Preparations for the Prevention and Treatment of Neuropathy |
| EP2879689A4 (en) * | 2012-08-02 | 2015-12-16 | Stealth Peptides Int Inc | METHOD FOR THE TREATMENT OF ATHEROSCLEROSIS |
| BR112015009072A2 (pt) * | 2012-10-22 | 2017-07-04 | Henry Ford Health Systems | métodos para redução dos riscos associados à insuficiência cardíaca e fatores associados à mesma |
| EP3287172A1 (en) * | 2012-12-06 | 2018-02-28 | Stealth Peptides International, Inc. | Combinations of peptide therapeutics and methods for using same |
| CA2916884C (en) | 2013-03-01 | 2021-02-09 | Stealth Biotherapeutics Corp | Methods for the treatment of mitochondrial disease |
| US9687519B2 (en) | 2013-03-01 | 2017-06-27 | Stealth Biotherapeutics Corp | Methods and compositions for the prevention or treatment of barth syndrome |
| CA2916977A1 (en) | 2013-06-26 | 2014-12-31 | Stealth Biotherapeutics Corp | Methods and compositions for detecting and diagnosing diseases and conditions |
| AU2014324705A1 (en) * | 2013-09-27 | 2016-04-21 | Cornell University | Use of aromatic-cationic peptides to treat cholesterol-induced mitochondrial dysfunction |
| WO2015084875A1 (en) * | 2013-12-02 | 2015-06-11 | Stealth Peptides International, Inc. | Compositions and methods for treating vitiligo |
| US10801068B2 (en) | 2015-10-16 | 2020-10-13 | The Trustees Of Columbia University In The City Of New York | JAG1 expression predicts therapeutic response in NASH |
| WO2017180535A1 (en) * | 2016-04-11 | 2017-10-19 | Carnot, Llc | Chiral peptides |
| CN108210902A (zh) * | 2016-12-15 | 2018-06-29 | 深圳瑞健生命科学研究院有限公司 | 预防和治疗脂肪肝的药物及其用途 |
| US11207387B2 (en) | 2016-12-15 | 2021-12-28 | Talengen International Limited | Method and drug for preventing and treating obesity |
| WO2018107692A1 (zh) * | 2016-12-15 | 2018-06-21 | 深圳瑞健生命科学研究院有限公司 | 一种预防和治疗脂肪代谢紊乱及其相关病症的方法 |
| EP3771467A1 (en) | 2019-07-30 | 2021-02-03 | Fundacio Institut de Recerca de l'Hospital de la Santa Creu i sant Pau | Ss-31 for the prevention and/or treatment of aneurysm |
| CN117881411A (zh) | 2021-06-01 | 2024-04-12 | 艾迪雅生物有限责任公司 | 用于眼部药物的延长释放药物递送系统和使用方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1938042A (zh) * | 2004-01-23 | 2007-03-28 | 科内尔研究基金会 | 用于减轻氧化性损伤的方法 |
| WO2008052044A2 (en) * | 2006-10-26 | 2008-05-02 | Xenoport, Inc. | Use of derivatives of propofol for treating diseases associated with oxidative stress |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5602100A (en) * | 1988-06-30 | 1997-02-11 | Astra Ab | Dermorphin analogs having pharmacological activity |
| EP0350221B1 (en) * | 1988-06-30 | 1996-04-17 | Astra Aktiebolag | Dermorphin analogs, their methods of preparation, pharmaceutical compositions, and methods of therapeutic treatment using the same |
| US5674980A (en) * | 1989-12-21 | 1997-10-07 | Biogen Inc | Fusion protein comprising tat-derived transport moiety |
| US5858784A (en) | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
| US5674534A (en) * | 1992-06-11 | 1997-10-07 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
| US5716644A (en) * | 1992-06-11 | 1998-02-10 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
| US5468798A (en) * | 1994-02-18 | 1995-11-21 | Whitford Corporation | Basecoat for a coating system |
| EP0747092B1 (en) * | 1995-06-09 | 2003-12-03 | Hisamitsu Pharmaceutical Co., Inc. | Matrix for iontophoresis |
| US5849761A (en) * | 1995-09-12 | 1998-12-15 | Regents Of The University Of California | Peripherally active anti-hyperalgesic opiates |
| US5885958A (en) * | 1997-03-25 | 1999-03-23 | Administrators Of The Tulane Educational Fund | Mu-opiate receptor peptides |
| US6221355B1 (en) * | 1997-12-10 | 2001-04-24 | Washington University | Anti-pathogen system and methods of use thereof |
| JP2002512954A (ja) * | 1998-04-24 | 2002-05-08 | マイトコー | ミトコンドリア関連疾患を処置するための化合物および方法 |
| SE9900961D0 (sv) * | 1999-03-16 | 1999-03-16 | Astra Ab | Novel compounds |
| DE60042338D1 (de) * | 1999-10-04 | 2009-07-16 | Univ New Jersey Med | TAR RNA bindende Peptide |
| US6759520B1 (en) * | 1999-10-28 | 2004-07-06 | The New England Medical Center Hospitals, Inc. | Chimeric analgesic peptides |
| US20050192215A1 (en) * | 2000-01-21 | 2005-09-01 | Malabika Ghosh | Methods and materials relating to novel polypeptides and polynucleotides |
| AU2001277908A1 (en) * | 2000-07-18 | 2002-01-30 | Cornell Research Foundation Inc. | Medicinal uses of mu-opioid receptor agonists |
| US6900178B2 (en) * | 2000-09-12 | 2005-05-31 | University Of Kentucky Research Foundation | Protection against ischemia and reperfusion injury |
| US20070015146A1 (en) * | 2001-05-22 | 2007-01-18 | Gene Logic, Inc. | Molecular nephrotoxicology modeling |
| HUE027110T2 (en) * | 2003-02-04 | 2016-08-29 | Cornell Res Foundation Inc | Use of an aromatic cationic peptide |
| AU2004252419B2 (en) * | 2003-05-01 | 2010-02-18 | Cornell Research Foundation, Inc | Method and carrier complexes for delivering molecules to cells |
| US7232824B2 (en) * | 2003-09-30 | 2007-06-19 | Scios, Inc. | Quinazoline derivatives as medicaments |
| EP1699476A1 (en) * | 2003-11-28 | 2006-09-13 | DeveloGen Aktiengesellschaft | Method for preventing and treating diabetes using dg119 |
| EP2305352A1 (en) * | 2004-04-02 | 2011-04-06 | Merck Sharp & Dohme Corp. | 5-alpha-reductase inhibitors for use in the treatment of men with metabolic and anthropometric disorders |
| US20050272101A1 (en) * | 2004-06-07 | 2005-12-08 | Prasad Devarajan | Method for the early detection of renal injury |
| EP3260127B1 (en) * | 2005-09-16 | 2019-05-01 | Cornell Research Foundation, Inc. | Aromatic-cationic peptide for use in a method of treating cerebral ischemia |
| US20070259377A1 (en) * | 2005-10-11 | 2007-11-08 | Mickey Urdea | Diabetes-associated markers and methods of use thereof |
| US20080027082A1 (en) * | 2006-06-19 | 2008-01-31 | Berthold Hocher | Use of adenosine a1 antagonists in radiocontrast media induced nephropathy |
| SI2252312T1 (sl) * | 2008-02-07 | 2014-08-29 | Cornell University, | Postopki za preprečevanje ali zdravljenje insulinske rezistence |
| CN104056248A (zh) * | 2008-02-26 | 2014-09-24 | 康奈尔大学 | 用于防止和治疗急性肾损伤的方法 |
| JP2013506696A (ja) * | 2009-10-05 | 2013-02-28 | コーネル ユニヴァーシティー | 心不全の予防又は処置の方法 |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1938042A (zh) * | 2004-01-23 | 2007-03-28 | 科内尔研究基金会 | 用于减轻氧化性损伤的方法 |
| WO2008052044A2 (en) * | 2006-10-26 | 2008-05-02 | Xenoport, Inc. | Use of derivatives of propofol for treating diseases associated with oxidative stress |
Non-Patent Citations (1)
| Title |
|---|
| 阿曼古丽: "代谢综合症与肾脏", 《中国名族民间医药》 * |
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| US20160199435A1 (en) | 2016-07-14 |
| JP2018052983A (ja) | 2018-04-05 |
| CN102647994A (zh) | 2012-08-22 |
| US20110039766A1 (en) | 2011-02-17 |
| JP5909182B2 (ja) | 2016-04-26 |
| EP3067061A1 (en) | 2016-09-14 |
| CA2770688A1 (en) | 2011-02-17 |
| CA2770688C (en) | 2018-06-05 |
| HK1247820A1 (zh) | 2018-10-05 |
| US20190209641A1 (en) | 2019-07-11 |
| JP2016041762A (ja) | 2016-03-31 |
| EP2464371A4 (en) | 2013-02-20 |
| JP6271785B2 (ja) | 2018-01-31 |
| JP2019104768A (ja) | 2019-06-27 |
| JP2013501802A (ja) | 2013-01-17 |
| US20180104304A1 (en) | 2018-04-19 |
| HUE029550T2 (en) | 2017-03-28 |
| WO2011019809A1 (en) | 2011-02-17 |
| EP2464371B1 (en) | 2016-03-16 |
| DK2464371T3 (en) | 2016-06-27 |
| EP2464371A1 (en) | 2012-06-20 |
| EP3427746A1 (en) | 2019-01-16 |
| ES2576746T3 (es) | 2016-07-11 |
| EP3251686A1 (en) | 2017-12-06 |
| CN105031605A (zh) | 2015-11-11 |
| JP2017132782A (ja) | 2017-08-03 |
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