ES2576746T3 - Métodos para prevenir o tratar síndrome metabólico - Google Patents
Métodos para prevenir o tratar síndrome metabólico Download PDFInfo
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- ES2576746T3 ES2576746T3 ES10808688.5T ES10808688T ES2576746T3 ES 2576746 T3 ES2576746 T3 ES 2576746T3 ES 10808688 T ES10808688 T ES 10808688T ES 2576746 T3 ES2576746 T3 ES 2576746T3
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- metabolic syndrome
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| EP3150215A1 (en) | 2009-08-24 | 2017-04-05 | Stealth Peptides International, Inc. | Methods and compositions for preventing or treating opthalmic conditions |
| CN102711785A (zh) * | 2009-10-05 | 2012-10-03 | 康奈尔大学 | 预防或治疗心力衰竭的方法 |
| EP3100739A1 (en) * | 2009-12-31 | 2016-12-07 | Stealth Peptides International, Inc. | Methods for performing a coronary artery bypass graft procedure |
| EP3170506B1 (en) * | 2012-03-30 | 2018-05-16 | Stealth Peptides International, Inc. | Methods and compositions for the prevention and treatment neuropathy |
| CN104661670A (zh) * | 2012-08-02 | 2015-05-27 | 康肽德生物医药技术有限公司 | 用于治疗动脉粥样硬化的方法 |
| MX2015005102A (es) * | 2012-10-22 | 2016-02-09 | Stealth Peptides Int Inc | Metodos para la reduccion de los riesgos asociados con el insuficiencia cardiaca y factores asociado con el mismo. |
| WO2014088631A1 (en) * | 2012-12-06 | 2014-06-12 | Stealth Peptides International, Inc. | Peptide therapeutics and methods for using same |
| CN117752766A (zh) * | 2013-03-01 | 2024-03-26 | 康德生物医疗有限公司 | 治疗线粒体疾病的方法 |
| CN115990242A (zh) | 2013-03-01 | 2023-04-21 | 康德生物医疗有限公司 | 预防或治疗巴斯综合征的方法和组合物 |
| WO2014209905A2 (en) | 2013-06-26 | 2014-12-31 | Stealth Peptides International, Inc. | Methods and compositions for detecting and diagnosing diseases and conditions |
| EP3049096B1 (en) * | 2013-09-27 | 2018-12-12 | Cornell University | Use of aromatic-cationic peptides to treat niemann-pick disease characterised by cholesterol-induced mitochondrial dysfunction |
| EP3077049B1 (en) | 2013-12-02 | 2019-06-19 | Stealth BioTherapeutics Corp | Compositions for use in treating vitiligo |
| US10801068B2 (en) | 2015-10-16 | 2020-10-13 | The Trustees Of Columbia University In The City Of New York | JAG1 expression predicts therapeutic response in NASH |
| AU2017249218B2 (en) * | 2016-04-11 | 2020-08-27 | Arcuate Therapeutics, Inc. | Chiral peptides |
| CN108210914A (zh) * | 2016-12-15 | 2018-06-29 | 深圳瑞健生命科学研究院有限公司 | 预防和治疗脂肪代谢紊乱及其相关病症的药物及其用途 |
| CN110366425A (zh) * | 2016-12-15 | 2019-10-22 | 泰伦基国际有限公司 | 一种预防动脉粥样硬化及其并发症的方法 |
| WO2018108161A1 (zh) | 2016-12-15 | 2018-06-21 | 深圳瑞健生命科学研究院有限公司 | 一种预防和治疗肥胖症的方法和药物 |
| EP3771467A1 (en) | 2019-07-30 | 2021-02-03 | Fundacio Institut de Recerca de l'Hospital de la Santa Creu i sant Pau | Ss-31 for the prevention and/or treatment of aneurysm |
| CN117881411A (zh) | 2021-06-01 | 2024-04-12 | 艾迪雅生物有限责任公司 | 用于眼部药物的延长释放药物递送系统和使用方法 |
Family Cites Families (34)
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| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
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| US6900178B2 (en) * | 2000-09-12 | 2005-05-31 | University Of Kentucky Research Foundation | Protection against ischemia and reperfusion injury |
| US20070015146A1 (en) * | 2001-05-22 | 2007-01-18 | Gene Logic, Inc. | Molecular nephrotoxicology modeling |
| EP2865385B1 (en) * | 2003-02-04 | 2016-11-16 | Cornell Research Foundation, Inc. | Uses of aromatic-cationic peptide |
| ZA200509229B (en) * | 2003-05-01 | 2007-03-28 | Cornell Res Foundation Inc | Method and carrier complexes for delivering molecules to cells |
| WO2005032481A2 (en) * | 2003-09-30 | 2005-04-14 | Scios Inc. | Quinazoline derivatives as medicaments |
| US20070110728A1 (en) * | 2003-11-28 | 2007-05-17 | Develogen Aktiengesellschaft | Method for preventing and treating diabetes using dg119 |
| CA2971928C (en) * | 2004-01-23 | 2019-01-08 | Cornell Research Foundation, Inc. | Methods for reducing oxidative damage |
| EP1734963A4 (en) * | 2004-04-02 | 2008-06-18 | Merck & Co Inc | METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER |
| US20050272101A1 (en) * | 2004-06-07 | 2005-12-08 | Prasad Devarajan | Method for the early detection of renal injury |
| EP3260127B1 (en) * | 2005-09-16 | 2019-05-01 | Cornell Research Foundation, Inc. | Aromatic-cationic peptide for use in a method of treating cerebral ischemia |
| US20070259377A1 (en) * | 2005-10-11 | 2007-11-08 | Mickey Urdea | Diabetes-associated markers and methods of use thereof |
| US20080027082A1 (en) * | 2006-06-19 | 2008-01-31 | Berthold Hocher | Use of adenosine a1 antagonists in radiocontrast media induced nephropathy |
| WO2008052044A2 (en) * | 2006-10-26 | 2008-05-02 | Xenoport, Inc. | Use of derivatives of propofol for treating diseases associated with oxidative stress |
| PL2252312T3 (pl) * | 2008-02-07 | 2014-10-31 | Univ Cornell | Sposoby zapobiegania lub leczenia insulinooporności |
| JP5677096B2 (ja) * | 2008-02-26 | 2015-02-25 | コーネル ユニヴァーシティー | 急性腎障害を予防および治療するための方法 |
| CN102711785A (zh) * | 2009-10-05 | 2012-10-03 | 康奈尔大学 | 预防或治疗心力衰竭的方法 |
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| US20110039766A1 (en) | 2011-02-17 |
| JP2016041762A (ja) | 2016-03-31 |
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| US20160199435A1 (en) | 2016-07-14 |
| EP2464371A4 (en) | 2013-02-20 |
| EP3067061A1 (en) | 2016-09-14 |
| JP2019104768A (ja) | 2019-06-27 |
| US20180104304A1 (en) | 2018-04-19 |
| JP6271785B2 (ja) | 2018-01-31 |
| JP2018052983A (ja) | 2018-04-05 |
| HK1247820A1 (zh) | 2018-10-05 |
| EP3427746A1 (en) | 2019-01-16 |
| CN107412724A (zh) | 2017-12-01 |
| US20190209641A1 (en) | 2019-07-11 |
| HUE029550T2 (en) | 2017-03-28 |
| DK2464371T3 (en) | 2016-06-27 |
| JP2017132782A (ja) | 2017-08-03 |
| JP5909182B2 (ja) | 2016-04-26 |
| WO2011019809A1 (en) | 2011-02-17 |
| CN105031605A (zh) | 2015-11-11 |
| CA2770688A1 (en) | 2011-02-17 |
| CN102647994A (zh) | 2012-08-22 |
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